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    Holocrine Poroma: A Distinctive Adnexal Tumor.
    Am J Dermatopathol 2017 Nov 1. Epub 2017 Nov 1.
    *Department of Pathology, The Dermatology Group, West Orange, NJ; and †Department of Pathology, Montefiore Medical Center, Bronx, NY.
    There are 36 cases of complex poroid tumors with folliculosebaceous and apocrine differentiation reported in the literature. The authors evaluated 111 poroid tumors including 63 typical eccrine poromas and 48 poroid tumors with folliculosebaceous elements. Folliculosebaceous poroid tumors (FSPT) had basaloid and squamous cells (100%), ducts with steatocystoma-like cuticles and holocrine secretions (89. Read More

    Reticulated acanthoma with sebaceous differentiation mimicking melanoma.
    Dermatol Pract Concept 2017 Jul 31;7(3):35-37. Epub 2017 Jul 31.
    Department of Dermatology, Mogi das Cruzes University, Mogi das Cruzes, Brazil.
    Reticulated acanthoma with sebaceous differentiation (RASD) is a rare, benign cutaneous tumor with peculiar histopathologic characteristics [1]. RASD had been described under various synonyms such as superficial epithelioma with sebaceous differentiation, sebocrine adenoma, poroma with sebaceous differentiation, and seborrheic keratosis with sebaceous differentiation [2]. Clinical differential diagnosis of RASD includes cutaneous superficial epithelial neoplasia such as Bowen's disease, superficial basal cell carcinoma (BCC) and intraepidermal eccrine poroma [1]. Read More

    A Large Lumbar Adnexal Neoplasm Presenting Characteristics of Eccrine Poroma and Poroid Hidradenoma.
    Case Rep Surg 2017 19;2017:9865672. Epub 2017 Sep 19.
    Department of Anatomy, Faculty of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
    Poroma is a rare benign neoplasm that derives from eccrine sweat glands epithelium. Its histological subtypes, with respect to its position within skin layers, are eccrine poroma, hidroacanthoma simplex, poroid hidradenoma, and dermal duct tumor. Poromas commonly exhibit benign clinical behavior as they are usually small and asymptomatic and do not exhibit malignant behavior. Read More

    A case of massive porocarcinoma.
    Ann R Coll Surg Engl 2017 Nov 15;99(8):e230-e232. Epub 2017 Sep 15.
    Children's Surgical Centre , Phnom Penh , Cambodia.
    A 53-year-old Cambodian woman presented with nodular masses on the right arm suggestive of a sarcoma-type malignancy. The masses were excised and identified as multiple benign eccrine poromas. The patient re-presented after two years with large relapsed tumours and axillary lymph node involvement. Read More

    Concomitant poroma and porocarcinoma.
    An Bras Dermatol 2017 Jul-Aug;92(4):550-552
    Faculty of Medicine, Pontificia Universidad Católica de Chile - Santiago, Chile.
    Eccrine poromas and porocarcinomas are adnexal tumors derived from the sweat duct epithelium. However, eccrine poroma is benign in nature, whilst eccrine porocarcinoma is regarded as its malignant counterpart. We report the case of a man who presented simultaneously with an eccrine poroma and eccrine porocarcinoma. Read More

    Eccrine Poroma of the Postauricular Area.
    Arch Craniofac Surg 2017 Mar 25;18(1):44-45. Epub 2017 Mar 25.
    Department of Plastic and Reconstructive Surgery, Dongguk University College of Medicine, Gyeongju, Korea.
    Eccrine poroma is a common benign cutaneous tumor that originates in an intraepidermal eccrine duct. This tumor exhibits acral distribution (sole, palm), and is rarely encountered in the head and neck area. In fact eccrine poroma in the postauricular area has only been rarely reported. Read More

    Eosinophilic variant of eccrine porocarcinoma of the scalp: Case report and review of the literature.
    Int J Womens Dermatol 2017 Sep 14;3(3):157-160. Epub 2017 Jul 14.
    Department of Dermatology, University of Connecticut School of Medicine, Farmington, CT.
    Porocarcinoma is a rare malignant neoplasm of the acrosyringium with metastatic potential that most commonly presents on the acral skin in older adults (mean age = 72 years). We present the case of a 43-year-old woman who developed a rapidly growing de novo porocarcinoma on the scalp with an unusual oncocytic appearance. The tumor consisted of benign eccrine poroma that arose from the epidermis and broad pushing borders with minimal cytological atypia but ample eosinophilic cytoplasm with numerous mitotic figures. Read More

    Hidroacanthoma simplex: dermoscopy and cryosurgery treatment.
    An Bras Dermatol 2017 Mar-Apr;92(2):253-255
    Department of Dermatology. Hospital do Servidor Público Estadual de São Paulo - São Paulo (SP), Brazil.
    Hidroacanthoma simplex is a rare intraepidermal neoplasia that arises from the acrosyringial portion of the eccrine duct. Malignant transformation of hidroacanthoma simplex is reported in the literature and the treatment is performed with wide excision or Mohs micrographic surgery. We report the first case successfully treated with cryosurgery with a long-term follow up. Read More

    Poroid Condyloma Versus Poroma With Atypias Because of Human Papillomavirus Infection.
    Appl Immunohistochem Mol Morphol 2017 Feb;25(2):e14-e17
    *Department of Cellular Pathology, Hospital El Bierzo, Ponferrada, Spain †Department of Pathology, Southern California Kaiser Permanente, Los Angeles Medical Center (LAMC), Los Angeles, CA.
    We present the case of a 43-year-old white man with a complex lesion at the base of the penis that combines features of both a poroma and a condyloma with human papillomavirus (HPV) infection, atypias, and focal ductal differentiation. It was a papillomatous lesion with epidermal hyperplasia, which mainly contained focally pigmented monotonous basaloid cells. Ductal lumina with cuticular cells were easily identified. Read More

    Nodular hidradenoma: Dermoscopic presentation.
    J Am Acad Dermatol 2017 Feb;76(2S1):S46-S48
    Department of Dermatology, University Hospital "Dr. José Eleuterio González," Universidad Autónoma de Nuevo León, Monterrey, Mexico. Electronic address:

    Porocarcinoma: A systematic review of literature with a single case report.
    Int J Surg Case Rep 2017 18;30:13-16. Epub 2016 Nov 18.
    Bioscience Center. Goran Street, Sulaimani, Kurdistan Region, Iraq.
    Introduction: Eccrine porocarcinoma is a very rare type of skin cancer. It is an aggressive dermatological malignancy. We presented a 62-year-old male with long history of a mass in left forearm complicated by distant metastasis and death. Read More

    Metastatic Eccrine Porocarcinoma: A Rare Case of Successful Treatment.
    Case Rep Oncol 2016 May-Aug;9(2):454-456. Epub 2016 Aug 17.
    Medical Oncology, Calvary Mater Newcastle, Waratah, N.S.W., Australia.
    The successful treatment of the rare malignancy eccrine porocarcinoma (EP) is extremely challenging, often not rewarding and when associated with metastatic disease, therapy results are disappointing. We present a unique case of treatment response of metastatic EP, with a significant disease-free interval. The patient has remained in clinical and radiological remission for 36 months since diagnosis of metastatic disease. Read More

    Pigmented eccrine poroma: dermoscopic and confocal features.
    Dermatol Pract Concept 2016 Jul 31;6(3):59-62. Epub 2016 Jul 31.
    Dermatology and Skin Cancer Unit, Arcispedale S. Maria Nuova, IRCCS, Reggio Emilia, Italy.
    Eccrine poroma is a rare benign adnexal tumor of epithelial cells originating from the terminal ductal portion of the sweat glands that is typically located on palms and soles, although other cutaneous sites can be affected [1]. It is usually nonpigmented even if there is a pigmented variant that corresponds to 17% of cases and it is usually underdiagnosed, since it is mistakenly confused with other pigmented tumors [2,3]. Dermoscopy and reflectance confocal microscopy (RCM) may assist in the correct diagnosis of this tumor. Read More

    Malignant Eccrine Poroma of the Vulva: An Intriguing Case of a Rare Tumor at an Unusual Site.
    Indian J Dermatol 2016 Jul-Aug;61(4):430-2
    Department of Dermatology, Venereology and Leprosy, IPGMER and SSKM Hospital, Kolkata, West Bengal, India.
    Malignant eccrine poroma is a rare malignancy of the eccrine sweat glands, occurring most frequently on the lower extremities. It affects both sexes equally usually in the 6(th) to 7(th) decade of life. Metastasis to regional lymph nodes may occur in 20% that may be fatal in 60% cases. Read More

    Characteristics of Eccrine Tumors in a Tertiary Institution: A 5-Year Retrospective Study.
    Skinmed 2016 1;14(3):175-80. Epub 2016 Jun 1.
    Department of Pathology, Yong Loo Lin School of Medicine, National University Health System and National University of Singapore.
    Eccrine tumors are adnexal tumors with a varied clinical presentation and wide histological spectrum. This study aims to consolidate data on the clinical characteristics of eccrine tumors to help improve clinical acumen and management of such tumors. Histopathological records from January 2008 to December 2012 were retrieved. Read More

    Dermoscopy of Skin Adnexal Neoplasms:A Continuous Challenge.
    Acta Dermatovenerol Croat 2016 Jun;24(2):158-60
    Mattia Fadel, MD, Dermatology Department, University of Trieste, Ospedale Maggiore, Piazza dell'Ospitale 1, 34135 Trieste, Italy;
    Dear Editor, Apocrine hidradenoma is a rare benign adnexal tumor related to the more common poroma, as they both originate from sweat glands. Hidradenoma usually has an eccrine differentiation, but an apocrine differentiation is possible. Due to its rarity and non-specific clinical appearance it is difficult to differentiate it from other malignant cutaneous lesions. Read More

    Eccrine Poroma Arising within Nevus Sebaceous.
    Case Rep Dermatol 2016 Jan-Apr;8(1):80-4. Epub 2016 Apr 20.
    Division of Dermatology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
    Nevus sebaceous is a congenital, benign hamartomatous lesion, characterized by a yellowish to skin-colored, hairless, verrucous plaque on the head and neck region. In later life, a secondary tumor, either benign or malignant, can develop within nevus sebaceous. Eccrine poroma developing on nevus sebaceous is extremely rare. Read More

    The challenging diagnosis of eccrine poromas.
    J Am Acad Dermatol 2016 Jun;74(6):e113-5
    Melanoma Unit, Dermatology Department, Hospital Clínic & IDIBAPS (Institut d'Investigacions Biomèdiques August Pi i Sunyer), Barcelona, Spain; Centro Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III (ISCIII), Barcelona, Spain; Universitat de Barcelona, Barcelona, Spain. Electronic address:

    Eccrine Poromatosis: Case Report, Review of the Literature, and Treatment.
    Skin Appendage Disord 2015 Sep 12;1(2):95-8. Epub 2015 Aug 12.
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, Ala., USA.
    Eccrine poromas arise from the intraepidermal region of the eccrine sweat duct and most often occur as a benign solitary tumor. There are few reports of the occurrence of multiple lesions, defined as poromatosis, which may present in patients who have undergone radiotherapy and/or polychemotherapy. We report the case of a 43-year-old male with a history of mantle cell lymphoma who had undergone 6 cycles of polychemotherapy. Read More

    "Pseudo-Circumscribed Palmar or Plantar Hypokeratosis (Pseudo-CPH)": a Histologic Pattern Secondary to Trauma; Further Characterization of a Known Entity.
    Am J Dermatopathol 2016 May;38(5):359-62
    *Dermatology and Advanced Skin Care, Ellicott City, MD; †Baldassano Dermatopathology, P.C., Blue Bell, PA; and ‡Drexel University College of Medicine, Philadelphia, PA.
    Circumscribed palmar or plantar hypokeratosis (CPH) is defined clinically as well-circumscribed areas of erythematous eroded skin mostly over thenar or hypothenar eminences of the palms and less commonly soles. Histologically, lesions demonstrate a characteristic abrupt drop-off in the cornified layer leading to broad areas of hypokeratosis. In the original description in 2002, Perez et al favored these lesions to be a distinctive epidermal malformation. Read More

    Eccrine Porocarcinoma presenting as an abdominal wall mass in a patient with ulcerative colitis-A rare case report.
    Int J Surg Case Rep 2016 2;23:40-3. Epub 2016 Apr 2.
    Hurley Medical Center, Trauma Services-7W, One Hurley Plaza, Flint, MI 48439, United States.
    Introduction: Eccrine porocarcinoma (EPC) is a rare malignancy of eccrine sweat glands. It is often seen during the sixth to eighth decades of life. We report the first case of eccrine porocarcinoma arising on the abdomen of a 21-year-old patient with ulcerative colitis. Read More

    Porocarcinomas harbor recurrent HRAS-activating mutations and tumor suppressor inactivating mutations.
    Hum Pathol 2016 May 7;51:25-31. Epub 2016 Jan 7.
    Department of Pathology, University of Michigan Health System, Ann Arbor, MI 48109; Michigan Center for Translational Pathology, University of Michigan Health System, Ann Arbor, MI 48109; Department of Urology, University of Michigan Health System, Ann Arbor, MI 48109; Comprehensive Cancer Center, University of Michigan Health System, Ann Arbor, MI 48109. Electronic address:
    Porocarcinomas are a rare eccrine carcinoma with significant metastatic potential. Oncogenic drivers of porocarcinomas have been underexplored, with PIK3CA-activating mutation reported in 1 case. We analyzed 5 porocarcinomas by next-generation sequencing using the DNA component of the Oncomine Comprehensive Assay, which provides data on copy number changes and mutational events in 126 cancer-relevant genes through multiplex polymerase chain reaction. Read More

    Eccrine Porocarcinoma of the Scalp: A Rare Case Report with Review of Literature.
    J Clin Diagn Res 2016 Jan 1;10(1):ED15-6. Epub 2016 Jan 1.
    Head of the Department, Department of Pathology, Sapthagiri Institute of Medical Sciences and Research Centre , Bangalore, India .
    Eccrine porocarcinoma (EPC) is a potentially lethal neoplasm of the skin that arises from the intraepidermal portion of the eccrine sweat glands. It was previously known as eccrine adenocarcinoma or malignant eccrine poroma. It commonly occurs between 60 to 80 years of age, usually arising from hands and feet. Read More

    Distinctive immunostaining of claudin-4 in spiradenomas.
    Ann Diagn Pathol 2016 Feb 28;20:44-7. Epub 2015 Oct 28.
    Department of Pathology, Gülhane Military Medical Academy and School of Medicine, Ankara, Turkey. Electronic address:
    The intercellular bridges are essential structures in maintaining the histologic organization of the epithelium, while providing a very efficient way to exchange molecules between cells and transduction of the cell-to-cell and matrix-to-cell signals. Derangement in those important structures' physical integrity and/or function, which can be assessed by the presence or absence of several intercellular bridge proteins including claudin-4, E-cadherin, and β-catenin, was found to be related to several phenomena in the path to the neoplastic transformation. However, these proteins have not been studied in the wide variety of the skin neoplasms, in detail. Read More

    Nevus sebaceus with basal cell carcinoma, poroma, and verruca vulgaris.
    Indian J Pathol Microbiol 2015 Oct-Dec;58(4):534-6
    Department of Pathology, Gülhane Military Medical Academy, Ankara, Turkey.
    Nevus sebaceus (NS) is a congenital, benign, hamartomatous lesion and it is possible to see several benign or malignant tumors accompanying it. One of these is the poroma, which is very rare, and has only been reported twice before, in the English literature. In this paper, we presented two new cases of NS. Read More

    An Unusual Clinical Presentation of Eccrine Poroma Occurring on the Auricle.
    Indian J Dermatol 2015 Sep-Oct;60(5):523
    Department of Dermatology, School of Medicine, Kyung Hee University, Seoul, Republic of Korea.
    Eccrine poromas are benign, slow-growing, solitary tumors originating from the intraepidermal portion of eccrine sweat ducts. Approximately 65% of these tumors occur on the soles of the feet, while 10% occur on the hands where a high concentration of eccrine sweat glands exists. Less frequently it occurs in other sites such as neck, chest, forehead, nose, and scalp with sporadic occurrences. Read More

    [A case report of eccrine porocarcinoma].
    Clin Ter 2015 ;166(4):e273-5
    Clinica Dermatologica, Az. Osp. Univ. di Cagliari, Italy.
    Eccrine porocarcinoma (EPC) is a rare malignant skin appendage tumour deriving from the intraepithelial ductal parts of the sweat glands. First described by Pinkus e Mehregan nel 1963 as an epidermotropic eccrine carcinoma, it is rarely reported in medical literature and represents 0.005-0. Read More

    Eccrine porocarcinoma shares dermoscopic characteristics with eccrine poroma: A report of three cases and review of the published work.
    J Dermatol 2016 Mar 1;43(3):332-5. Epub 2015 Sep 1.
    Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan.
    Eccrine porocarcinoma (EPC) is a rare malignant skin tumor presumably arising from the intraepidermal ductal portion of the sweat gland. EPC occasionally mimics eccrine poroma (EP), seborrhea keratosis (SK), basal cell carcinoma (BCC), pyogenic granuloma (PG) and amelanotic melanoma with its clinical appearance as a pink nodule. Dermoscopy is an invaluable technique in diagnosing skin tumors. Read More

    Eccrine poroma and porocarcinoma on the same unusual location: report on two cases.
    An Bras Dermatol 2015 May-Jun;90(3 Suppl 1):69-72
    Third Affiliated Hospital, Sun Yat-sen University, Guangdong, CN.
    Eccrine poroma is a benign adnexal tumour of the uppermost portion of the intraepidermal eccrine sweat gland duct and acrosyringium. Eccrine porocarcinoma is the malignant phenotype arising from the intraepidermal portion of the eccrine sweat gland duct epithelium or from pre-existing eccrine poroma. Both commonly occur in the palms or sides of the feet; these areas have a high concentration of eccrine sweat glands. Read More

    Intraepidermal benign sebaceous neoplasm: apocrine poroma (hidroacanthoma simplex type) with extensive sebaceous differentiation with sebaceoma-like features.
    J Cutan Pathol 2016 Feb 21;43(2):171-6. Epub 2015 Sep 21.
    Department of Pathology, Faculty of Medicine, Saga University, Saga, Japan.
    We herein report a patient who clinically presented with a yellowish, flat plaque that histopathologically showed a benign lesion mainly composed of intraepidermal basaloid nests with sebaceous differentiation. This lesion was considered to be fundamentally apocrine poroma (hidroacanthoma simplex type) with sebaceous differentiation. Nests composed of typical poroid cells were seen, and the results of immunostaining for lumican supported this diagnosis and excluded the possibility of clonal seborrheic keratosis. Read More

    Multiple apocrine poromas: a new case report.
    J Cutan Pathol 2015 Nov 16;42(11):894-6. Epub 2015 Sep 16.
    Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, Kobe, Japan.
    Apocrine poromas are rare and distinctive benign adnexal neoplasms featuring tumor cells differentiating toward folliculosebaceous-apocrine units. We report an extremely rare case with multiple apocrine poromas in a single patient. Fifteen tumors were distributed on the head, neck, forearm and axilla of a 74-year-old man. Read More

    [Tumors with poroid features: a clinicopathologic analysis of 45 cases].
    Zhonghua Bing Li Xue Za Zhi 2015 Mar;44(3):179-83
    Objective: To investigate the clinicopathological features and the differential diagnosis of poroma and porocarcinoma.

    Methods: Histopathological characteristics and clinical data of 35 cases of poroma and 10 cases of porocarcinoma were analyzed retrospectively.

    Results: The average age of 35 patients of poroma was 48 years. Read More

    Subcutaneous porocarcinoma clinically presenting as a soft tissue tumor.
    J Cutan Pathol 2015 Nov 16;42(11):897-902. Epub 2015 Sep 16.
    Department of Pathology, University of Yamanashi, Interdisciplinary Graduate School of Medicine and Engineering, Yamanashi, Japan.
    Porocarcinoma is a rare malignancy with glandular adnexal differentiation. A 38-year-old Japanese man noticed a subcutaneous mass in right inguinal region about 20 years prior to being examined. Radiological examinations demonstrated the mass, 11 × 10 cm in size, was in the subcutaneous fat tissue. Read More

    [Multiple recurrent eccrine porocarcinoma with inguinal metastasis. A case report].
    Cir Cir 2016 Jan-Feb;84(1):73-6. Epub 2015 Aug 1.
    Servicio de Cirugía Plástica, Estética y Reparadora, Complejo Hospitalario Universitario Insular-Materno Infantil, Las Palmas de Gran Canaria, España.
    Background: Eccrine porocarcinoma, first described in 1963, is a rare malignant lesion arising from the eccrine sweat glands. It is usually a primary tumour, or even more common, a malignant degeneration of an eccrine poroma. It usually affects older persons and is located most commonly on the lower extremities. Read More

    An unknown mass: the differential diagnosis of digit tumors.
    Int J Dermatol 2015 Nov 30;54(11):1214-25. Epub 2015 Jul 30.
    Veterans Affairs Hospital & SUNY Downstate, Brooklyn, NY, USA.
    There is little discussion of tumors arising in the digits in the dermatology literature. The patient with an undifferentiated mass of the finger is frequently encountered in the clinic, and variances in presentation of common and uncommon entities pose a challenge that may prompt further investigation for proper diagnosis and treatment. In this review, the authors illustrate the approach and work-up of an unknown digit mass of a 45-year-old female patient. Read More

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