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    Eccrine Poroma with Rapid Growth during Pregnancy: A Case Report and Review of the Literature.
    Ann Dermatol 2018 Apr 21;30(2):222-225. Epub 2018 Feb 21.
    Department of Dermatology, SMG-SNU Boramae Medical Center, Seoul, Korea.
    Eccrine poroma is a benign solitary tumor with acrosyringeal differentiation that usually occurs on the sole or either side of the foot. Rapid growth of eccrine poroma during pregnancy has rarely been reported. We demonstrate a unique case of a 37-year-old pregnant woman who suffered from enlarged eccrine poroma on her left palm, which was tiny for 10 years but suddenly grew to a size of bean-sized reddish brown colored, pedunculated mass during pregnancy. Read More

    Homeobox transcriptional factor engrailed homeobox 1 is expressed specifically in normal and neoplastic sweat gland cells.
    Histopathology 2018 Feb 12. Epub 2018 Feb 12.
    Department of Human Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
    Aims: A number of homeobox transcriptional factors are utilised as organ-specific markers in the histopathological diagnosis of neoplasms. We have screened a homeobox gene that is expressed specifically in normal sweat gland cells and is useful for the histopathological diagnosis of sweat gland neoplasms.

    Methods And Results: By screening an open database resource of The Human Protein Atlas, 37 genes among the 235 homeobox transcriptional factors were found to be expressed specifically in the skin. Read More

    Cytomorphology of Skin Adnexal Tumors: A Tale of Two Scalp Swellings.
    J Cytol 2018 Jan-Mar;35(1):60-62
    Department of Pathology and Lab Medicine, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India.
    The primary and metastatic tumors of the skin can be effectively diagnosed by fine needle aspiration cytology (FNAC); however, the cytomorphological features of skin adnexal tumors are rarely described in the literature. We hereby describe the cytological features of two histologically confirmed cases of benign skin adnexal tumors. Case 1 is of a 46-year-old female who presented with an elevated firm nodule over the scalp. Read More

    Cuticular Poroma: A Poroma Mostly Composed of Cuticular Cells (Cuticuloma).
    Am J Dermatopathol 2017 Dec 28. Epub 2017 Dec 28.
    Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.
    Poromas are benign cutaneous adnexal neoplasms with differentiation toward excretory ducts of eccrine and apocrine glands. They are mainly composed of solid aggregates of small, monomorphous, round, and basophilic poroid cells, with a lower proportion of larger, squamous, eosinophilic cuticular cells, which are lining ductal structures with an eosinophilic luminal cuticle. In most cases of poromas, cuticular cells represent a small proportion of the neoplastic aggregates. Read More

    Targeted molecular profiling reveals genetic heterogeneity of poromas and porocarcinomas.
    Pathology 2018 Apr 18;50(3):327-332. Epub 2017 Dec 18.
    Institute of Pathology, University of Heidelberg, Heidelberg, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany. Electronic address:
    The genetic landscape of rare benign tumours and their malignant counterparts is still largely unexplored. While recent work showed that mutant HRAS is present in subsets of poromas and porocarcinomas, a more comprehensive genetic view on these rare adnexal neoplasms is lacking. Using high-coverage next generation sequencing, we investigated the mutational profile of 50 cancer-related genes in 12 cases (six poromas and six porocarcinomas). Read More

    Periungual Eccrine Poroma Masquerading as Ingrown Toenails .
    J Am Podiatr Med Assoc 2017 Nov;107(6):551-555
    Eccrine poroma is a rare benign adnexal neoplasm originating from a portion of the intraepidermal eccrine sweat gland duct and the acrosyringium. Typically, the lesions are asymptomatic, slow-growing nodules, which may be found in any sweat gland-bearing area. Multiple red lacunae, glomerular vessels, hairpin vessels, flower- and leaf-like vascular patterns, a polymorphic vascular pattern, globule/lacunae-like structures, a frog egg-like appearance, and comedo-like openings have been defined as characteristic dermoscopic patterns of the disease. Read More

    A synchronous incidence of eccrine porocarcinoma of the forearm and facial squamous cell carcinoma: A case report.
    Int J Surg Case Rep 2018 8;42:116-120. Epub 2017 Dec 8.
    Department of Pathology, Sultanah Nur Zahirah Hospital, Jalan Sultan Mahmud, 20400, Kuala Terengganu, Terengganu, Malaysia.
    Introduction: Cutaneous appendageal tumor can differentiate towards or arise from either pilosebaceous apparatus or the eccrine sweat glands. Appendageal tumors are relatively rare, their clinical appearance is non-specific, and the vast majority are not diagnosed until after excision. Eccrine porocarcinoma (EP), also known as malignant eccrine poroma is a rare adnexal tumor arising from the intraepithelial ductal parts of the sweat gland. Read More

    Dermoscopic features and patterns of poromas: a multicentre observational case-control study conducted by the International Dermoscopy Society.
    J Eur Acad Dermatol Venereol 2017 Dec 1. Epub 2017 Dec 1.
    Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
    Background: Poromas are benign cutaneous sweat gland tumours that are challenging to identify. The dermoscopic features of poromas are not well characterized.

    Objective: To determine the clinical-dermoscopic features of poromas. Read More

    Holocrine Poroma: A Distinctive Adnexal Tumor.
    Am J Dermatopathol 2017 Nov 1. Epub 2017 Nov 1.
    *Department of Pathology, The Dermatology Group, West Orange, NJ; and †Department of Pathology, Montefiore Medical Center, Bronx, NY.
    There are 36 cases of complex poroid tumors with folliculosebaceous and apocrine differentiation reported in the literature. The authors evaluated 111 poroid tumors including 63 typical eccrine poromas and 48 poroid tumors with folliculosebaceous elements. Folliculosebaceous poroid tumors (FSPT) had basaloid and squamous cells (100%), ducts with steatocystoma-like cuticles and holocrine secretions (89. Read More

    Reticulated acanthoma with sebaceous differentiation mimicking melanoma.
    Dermatol Pract Concept 2017 Jul 31;7(3):35-37. Epub 2017 Jul 31.
    Department of Dermatology, Mogi das Cruzes University, Mogi das Cruzes, Brazil.
    Reticulated acanthoma with sebaceous differentiation (RASD) is a rare, benign cutaneous tumor with peculiar histopathologic characteristics [1]. RASD had been described under various synonyms such as superficial epithelioma with sebaceous differentiation, sebocrine adenoma, poroma with sebaceous differentiation, and seborrheic keratosis with sebaceous differentiation [2]. Clinical differential diagnosis of RASD includes cutaneous superficial epithelial neoplasia such as Bowen's disease, superficial basal cell carcinoma (BCC) and intraepidermal eccrine poroma [1]. Read More

    A Large Lumbar Adnexal Neoplasm Presenting Characteristics of Eccrine Poroma and Poroid Hidradenoma.
    Case Rep Surg 2017 19;2017:9865672. Epub 2017 Sep 19.
    Department of Anatomy, Faculty of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
    Poroma is a rare benign neoplasm that derives from eccrine sweat glands epithelium. Its histological subtypes, with respect to its position within skin layers, are eccrine poroma, hidroacanthoma simplex, poroid hidradenoma, and dermal duct tumor. Poromas commonly exhibit benign clinical behavior as they are usually small and asymptomatic and do not exhibit malignant behavior. Read More

    A case of massive porocarcinoma.
    Ann R Coll Surg Engl 2017 Nov 15;99(8):e230-e232. Epub 2017 Sep 15.
    Children's Surgical Centre , Phnom Penh , Cambodia.
    A 53-year-old Cambodian woman presented with nodular masses on the right arm suggestive of a sarcoma-type malignancy. The masses were excised and identified as multiple benign eccrine poromas. The patient re-presented after two years with large relapsed tumours and axillary lymph node involvement. Read More

    Concomitant poroma and porocarcinoma.
    An Bras Dermatol 2017 Jul-Aug;92(4):550-552
    Faculty of Medicine, Pontificia Universidad Católica de Chile - Santiago, Chile.
    Eccrine poromas and porocarcinomas are adnexal tumors derived from the sweat duct epithelium. However, eccrine poroma is benign in nature, whilst eccrine porocarcinoma is regarded as its malignant counterpart. We report the case of a man who presented simultaneously with an eccrine poroma and eccrine porocarcinoma. Read More

    Eccrine Poroma of the Postauricular Area.
    Arch Craniofac Surg 2017 Mar 25;18(1):44-45. Epub 2017 Mar 25.
    Department of Plastic and Reconstructive Surgery, Dongguk University College of Medicine, Gyeongju, Korea.
    Eccrine poroma is a common benign cutaneous tumor that originates in an intraepidermal eccrine duct. This tumor exhibits acral distribution (sole, palm), and is rarely encountered in the head and neck area. In fact eccrine poroma in the postauricular area has only been rarely reported. Read More

    Eosinophilic variant of eccrine porocarcinoma of the scalp: Case report and review of the literature.
    Int J Womens Dermatol 2017 Sep 14;3(3):157-160. Epub 2017 Jul 14.
    Department of Dermatology, University of Connecticut School of Medicine, Farmington, CT.
    Porocarcinoma is a rare malignant neoplasm of the acrosyringium with metastatic potential that most commonly presents on the acral skin in older adults (mean age = 72 years). We present the case of a 43-year-old woman who developed a rapidly growing de novo porocarcinoma on the scalp with an unusual oncocytic appearance. The tumor consisted of benign eccrine poroma that arose from the epidermis and broad pushing borders with minimal cytological atypia but ample eosinophilic cytoplasm with numerous mitotic figures. Read More

    Hidroacanthoma simplex: dermoscopy and cryosurgery treatment.
    An Bras Dermatol 2017 Mar-Apr;92(2):253-255
    Department of Dermatology. Hospital do Servidor Público Estadual de São Paulo - São Paulo (SP), Brazil.
    Hidroacanthoma simplex is a rare intraepidermal neoplasia that arises from the acrosyringial portion of the eccrine duct. Malignant transformation of hidroacanthoma simplex is reported in the literature and the treatment is performed with wide excision or Mohs micrographic surgery. We report the first case successfully treated with cryosurgery with a long-term follow up. Read More

    Eccrine Syringofibroadenoma in Association With Acquired Epidermodysplasia Verruciformis.
    Am J Dermatopathol 2017 Jul;39(7):534-537
    Departments of *Pathology, and †Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL; ‡Robert H. Lurie Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL; §Division of Dermatology, Department of Medicine, NorthShore University HealthSystem Vernon Hills, IL; and ¶Dermatology and Aesthetics of Wicker Park, Chicago, IL.
    A 75-year-old man with human immunodeficiency virus infection and numerous biopsy-proven warts for 10 years, refractory to cryosurgery, cimetidine, and topical imiquimod, presented with numerous pink to hypopigmented verrucous papules and plaques involving the face, trunk, buttocks, and groin. Laboratory evaluation revealed a CD4 T-cell count of 62 cells per microliter and human immunodeficiency virus viral load of <117 copies per milliliter. Biopsy of a plaque groin lesion was performed. Read More

    Poroid Condyloma Versus Poroma With Atypias Because of Human Papillomavirus Infection.
    Appl Immunohistochem Mol Morphol 2017 02;25(2):e14-e17
    *Department of Cellular Pathology, Hospital El Bierzo, Ponferrada, Spain †Department of Pathology, Southern California Kaiser Permanente, Los Angeles Medical Center (LAMC), Los Angeles, CA.
    We present the case of a 43-year-old white man with a complex lesion at the base of the penis that combines features of both a poroma and a condyloma with human papillomavirus (HPV) infection, atypias, and focal ductal differentiation. It was a papillomatous lesion with epidermal hyperplasia, which mainly contained focally pigmented monotonous basaloid cells. Ductal lumina with cuticular cells were easily identified. Read More

    Nodular hidradenoma: Dermoscopic presentation.
    J Am Acad Dermatol 2017 Feb;76(2S1):S46-S48
    Department of Dermatology, University Hospital "Dr. José Eleuterio González," Universidad Autónoma de Nuevo León, Monterrey, Mexico. Electronic address:

    Vulvar eccrine porocarcinoma: report of a case and literature review.
    Rom J Morphol Embryol 2017 ;58(4):1611-1616
    Pathology Unit, Department of Medical and Surgical Sciences, University of Cantabria and IDIVAL, Santander, Spain;
    Adnexal carcinomas of the vulva are rare tumors. A case of an 83-year-old woman with a 3.5 cm vulvar lobulated mass that grew over an 18-month period is reported. Read More

    Porocarcinoma: A systematic review of literature with a single case report.
    Int J Surg Case Rep 2017 18;30:13-16. Epub 2016 Nov 18.
    Bioscience Center. Goran Street, Sulaimani, Kurdistan Region, Iraq.
    Introduction: Eccrine porocarcinoma is a very rare type of skin cancer. It is an aggressive dermatological malignancy. We presented a 62-year-old male with long history of a mass in left forearm complicated by distant metastasis and death. Read More

    Metastatic Eccrine Porocarcinoma: A Rare Case of Successful Treatment.
    Case Rep Oncol 2016 May-Aug;9(2):454-456. Epub 2016 Aug 17.
    Medical Oncology, Calvary Mater Newcastle, Waratah, N.S.W., Australia.
    The successful treatment of the rare malignancy eccrine porocarcinoma (EP) is extremely challenging, often not rewarding and when associated with metastatic disease, therapy results are disappointing. We present a unique case of treatment response of metastatic EP, with a significant disease-free interval. The patient has remained in clinical and radiological remission for 36 months since diagnosis of metastatic disease. Read More

    Pigmented eccrine poroma: dermoscopic and confocal features.
    Dermatol Pract Concept 2016 Jul 31;6(3):59-62. Epub 2016 Jul 31.
    Dermatology and Skin Cancer Unit, Arcispedale S. Maria Nuova, IRCCS, Reggio Emilia, Italy.
    Eccrine poroma is a rare benign adnexal tumor of epithelial cells originating from the terminal ductal portion of the sweat glands that is typically located on palms and soles, although other cutaneous sites can be affected [1]. It is usually nonpigmented even if there is a pigmented variant that corresponds to 17% of cases and it is usually underdiagnosed, since it is mistakenly confused with other pigmented tumors [2,3]. Dermoscopy and reflectance confocal microscopy (RCM) may assist in the correct diagnosis of this tumor. Read More

    Malignant Eccrine Poroma of the Vulva: An Intriguing Case of a Rare Tumor at an Unusual Site.
    Indian J Dermatol 2016 Jul-Aug;61(4):430-2
    Department of Dermatology, Venereology and Leprosy, IPGMER and SSKM Hospital, Kolkata, West Bengal, India.
    Malignant eccrine poroma is a rare malignancy of the eccrine sweat glands, occurring most frequently on the lower extremities. It affects both sexes equally usually in the 6(th) to 7(th) decade of life. Metastasis to regional lymph nodes may occur in 20% that may be fatal in 60% cases. Read More

    Characteristics of Eccrine Tumors in a Tertiary Institution: A 5-Year Retrospective Study.
    Skinmed 2016 1;14(3):175-80. Epub 2016 Jun 1.
    Department of Pathology, Yong Loo Lin School of Medicine, National University Health System and National University of Singapore.
    Eccrine tumors are adnexal tumors with a varied clinical presentation and wide histological spectrum. This study aims to consolidate data on the clinical characteristics of eccrine tumors to help improve clinical acumen and management of such tumors. Histopathological records from January 2008 to December 2012 were retrieved. Read More

    Dermoscopy of Skin Adnexal Neoplasms:A Continuous Challenge.
    Acta Dermatovenerol Croat 2016 Jun;24(2):158-60
    Mattia Fadel, MD, Dermatology Department, University of Trieste, Ospedale Maggiore, Piazza dell'Ospitale 1, 34135 Trieste, Italy;
    Dear Editor, Apocrine hidradenoma is a rare benign adnexal tumor related to the more common poroma, as they both originate from sweat glands. Hidradenoma usually has an eccrine differentiation, but an apocrine differentiation is possible. Due to its rarity and non-specific clinical appearance it is difficult to differentiate it from other malignant cutaneous lesions. Read More

    Eccrine Poroma Arising within Nevus Sebaceous.
    Case Rep Dermatol 2016 Jan-Apr;8(1):80-4. Epub 2016 Apr 20.
    Division of Dermatology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
    Nevus sebaceous is a congenital, benign hamartomatous lesion, characterized by a yellowish to skin-colored, hairless, verrucous plaque on the head and neck region. In later life, a secondary tumor, either benign or malignant, can develop within nevus sebaceous. Eccrine poroma developing on nevus sebaceous is extremely rare. Read More

    The challenging diagnosis of eccrine poromas.
    J Am Acad Dermatol 2016 Jun;74(6):e113-5
    Melanoma Unit, Dermatology Department, Hospital Clínic & IDIBAPS (Institut d'Investigacions Biomèdiques August Pi i Sunyer), Barcelona, Spain; Centro Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III (ISCIII), Barcelona, Spain; Universitat de Barcelona, Barcelona, Spain. Electronic address:

    Eccrine Poromatosis: Case Report, Review of the Literature, and Treatment.
    Skin Appendage Disord 2015 Sep 12;1(2):95-8. Epub 2015 Aug 12.
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, Ala., USA.
    Eccrine poromas arise from the intraepidermal region of the eccrine sweat duct and most often occur as a benign solitary tumor. There are few reports of the occurrence of multiple lesions, defined as poromatosis, which may present in patients who have undergone radiotherapy and/or polychemotherapy. We report the case of a 43-year-old male with a history of mantle cell lymphoma who had undergone 6 cycles of polychemotherapy. Read More

    "Pseudo-Circumscribed Palmar or Plantar Hypokeratosis (Pseudo-CPH)": a Histologic Pattern Secondary to Trauma; Further Characterization of a Known Entity.
    Am J Dermatopathol 2016 May;38(5):359-62
    *Dermatology and Advanced Skin Care, Ellicott City, MD; †Baldassano Dermatopathology, P.C., Blue Bell, PA; and ‡Drexel University College of Medicine, Philadelphia, PA.
    Circumscribed palmar or plantar hypokeratosis (CPH) is defined clinically as well-circumscribed areas of erythematous eroded skin mostly over thenar or hypothenar eminences of the palms and less commonly soles. Histologically, lesions demonstrate a characteristic abrupt drop-off in the cornified layer leading to broad areas of hypokeratosis. In the original description in 2002, Perez et al favored these lesions to be a distinctive epidermal malformation. Read More

    Eccrine Porocarcinoma presenting as an abdominal wall mass in a patient with ulcerative colitis-A rare case report.
    Int J Surg Case Rep 2016 2;23:40-3. Epub 2016 Apr 2.
    Hurley Medical Center, Trauma Services-7W, One Hurley Plaza, Flint, MI 48439, United States.
    Introduction: Eccrine porocarcinoma (EPC) is a rare malignancy of eccrine sweat glands. It is often seen during the sixth to eighth decades of life. We report the first case of eccrine porocarcinoma arising on the abdomen of a 21-year-old patient with ulcerative colitis. Read More

    Porocarcinomas harbor recurrent HRAS-activating mutations and tumor suppressor inactivating mutations.
    Hum Pathol 2016 May 7;51:25-31. Epub 2016 Jan 7.
    Department of Pathology, University of Michigan Health System, Ann Arbor, MI 48109; Michigan Center for Translational Pathology, University of Michigan Health System, Ann Arbor, MI 48109; Department of Urology, University of Michigan Health System, Ann Arbor, MI 48109; Comprehensive Cancer Center, University of Michigan Health System, Ann Arbor, MI 48109. Electronic address:
    Porocarcinomas are a rare eccrine carcinoma with significant metastatic potential. Oncogenic drivers of porocarcinomas have been underexplored, with PIK3CA-activating mutation reported in 1 case. We analyzed 5 porocarcinomas by next-generation sequencing using the DNA component of the Oncomine Comprehensive Assay, which provides data on copy number changes and mutational events in 126 cancer-relevant genes through multiplex polymerase chain reaction. Read More

    Eccrine Porocarcinoma of the Scalp: A Rare Case Report with Review of Literature.
    J Clin Diagn Res 2016 Jan 1;10(1):ED15-6. Epub 2016 Jan 1.
    Head of the Department, Department of Pathology, Sapthagiri Institute of Medical Sciences and Research Centre , Bangalore, India .
    Eccrine porocarcinoma (EPC) is a potentially lethal neoplasm of the skin that arises from the intraepidermal portion of the eccrine sweat glands. It was previously known as eccrine adenocarcinoma or malignant eccrine poroma. It commonly occurs between 60 to 80 years of age, usually arising from hands and feet. Read More

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