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    1 OF 23

    Temozolomide-induced inflammation of disseminated superficial actinic porokeratosis.
    Dermatol Online J 2018 Mar 15;24(3). Epub 2018 Mar 15.
    Department of Internal Medicine, Division of Dermatology, The Ohio State University Wexner Medical Center, Gahanna, Ohio.
    We report a case of temozolomide (TMZ)-induced inflammation of disseminated superficial actinic porokeratosis (DSAP), an uncommon and pre-malignant cutaneous disorder. Dermatologists and oncologists should be aware of this cutaneous eruption of DSAP associated with TMZ to prevent the discontinuation of effective medical therapy in cancer patients. Read More

    Genitogluteal porokeratosis in an HIV-positive man: a case report and review of the literature on genital porokeratosis.
    Dermatol Online J 2018 Mar 15;24(3). Epub 2018 Mar 15.
    Department of Dermatology, University of California San Diego, La Jolla, California.
    Genitogluteal porokeratosis is a disorder of keratinization that may present in men in their fourth decade of life. We describe a 52-year-old human immunodeficiency virus (HIV)-positive man with history of anal squamous cell carcinoma who developed verrucous lesions on the buttocks and genitals. The buttock lesions presented shortly after radiotherapy for anal carcinoma a decade prior, whereas the genital lesions presented three months prior in areas treated with injectable medication for erectile dysfunction. Read More

    A report and follow up of a patient with disseminated superficial actinic porokeratosis (DSAP) undergoing novel systemic treatment with palifermin (a keratinocyte growth factor) during chemotherapy.
    Dermatol Online J 2018 Feb 15;24(2). Epub 2018 Feb 15.
    Department of Medicine, St Vincent's Hospital, Melbourne, Victoria, Australia,.
    Disseminated superficial actinic porokeratosis (DSAP) is an inherited dermatosis triggered by chronic ultraviolet light exposure. Cosmetic improvement has been noted with topical therapies or laser treatment. Lesions of DSAP are precancerous, having been reported to develop into squamous cell carcinomas (SCCs) or basal cell carcinomas (BCCs) occasionally. Read More

    Disseminated Superficial Actinic Porokeratosis in a Patient with Psoriasis, after Long-Term Narrowband Ultraviolet B Phototherapy.
    Ann Dermatol 2018 Apr 21;30(2):211-213. Epub 2018 Feb 21.
    Department of Dermatology, Soonchunhyang University Bucheon Hospital, Bucheon, Korea.
    Porokeratosis is a rare epidermal disorder characterized by annular or linear hyperkeratotic plaques with slightly raised thread-like borders, and in most cases, atrophic centers. Disseminated superficial porokeratosis and disseminated superficial actinic porokeratosis (DSAP), which primarily involve sun-exposed areas, are common types of porokeratoses. Histologically, a column of parakeratotic cells, a so-called cornoid lamella, is a hallmark of porokeratosis. Read More

    Disseminated Porokeratosis with Idiopathic Thrombocytopenia - Case Report and Literature Review of Porokeratosis and Related Disorders.
    Open Access Maced J Med Sci 2018 Jan 13;6(1):139-142. Epub 2018 Jan 13.
    "Onkoderma"- Policlinic for Dermatology and Dermatologic Surgery, Sofia, Bulgaria.
    Background: Porokeratosis is characterised by one or more atrophic patches surrounded by a distinctive peripheral keratotic ridge, typically found on sun-exposed areas, with several clinical variants and typical histological findings. Despite ultraviolet radiation, varies antibody - related autoimmune disease treated with systemic steroids and other immunosuppressive conditions such as chronic liver disease, HIV and organ transplantations have been implicated in its etiopathology.

    Case Report: We present a case of porokeratosis, associated with idiopathic thrombocytopenia in 74 - year old, otherwise healthy male patient, as we discuss the previously reported associated disorders. Read More

    Pediatric penile porokeratosis: A case report.
    Pediatr Dermatol 2018 Mar 16;35(2):e103-e104. Epub 2018 Jan 16.
    Department of Dermatology, University of California, San Diego, La Jolla, CA, USA.
    We present what we believe to be the second case of pediatric penile porokeratosis and the youngest case reported. A 6-year-old boy presented with a pruritic, verrucous growth at the urethral meatus that recurred after two meatotomies. The diagnosis of porokeratosis was confirmed by biopsy. Read More

    Porokeratotic eccrine and hair follicle nevus: a report of two cases and review of the literature.
    An Bras Dermatol 2017 ;92(5 Suppl 1):121-125
    Department of Dermatology, Complejo Hospitalario de Navarra - Pamplona, Spain.
    Porokeratotic eccrine and hair follicle nevus is a very rare non-hereditary disorder of keratinization with eccrine and hair follicle involvement with only 9 cases described in the literature. In 2009 the term porokeratotic anexial ostial nevus was proposed to comprehend porokeratotic eccrine and hair follicle nevus and a related and more common process without follicular involvement: porokeratotic eccrine ostial and dermal duct nevus Recent findings suggest that both entities may be produced by a mutation in GJB2 gene, which is associated to KID syndrome. Herein we report 2 cases of porokeratotic eccrine and hair follicle nevus and review the existing cases in the Spanish and English literature. Read More

    Hyperkeratotic porokeratosis ptychotropica with satellite lesions: a rare presentation of an unusual variant of porokeratosis.
    Acta Dermatovenerol Alp Pannonica Adriat 2017 Dec;26(4):113-114
    Department of Dermatology, Dr. Vasantrao Pawar Medical College, Hospital and Research Center, Nashik, Maharashtra, India.
    Since its description in 1995, porokeratosis ptychotropica (PP) has remained a less-recognized variant of porokeratosis (PK). The term porokeratosis ptychotropica was coined in reference to its characteristic of affecting body folds. It mimics many other dermatological diseases and is therefore often misdiagnosed. Read More

    Linear porokeratosis associated with multiple squamous cell carcinomas.
    Cutis 2017 Nov;100(5):E11-E14
    Department of Dermatology, University of Pittsburgh, Pennsylvania, USA.
    Linear porokeratosis is a rare subtype of porokeratosis with a higher rate of malignant transformation than other subtypes of porokeratosis. Identification of cornoid lamellae on histology allows for definitive diagnosis, which makes high clinical suspicion and appropriate biopsy essential in establishing the correct diagnosis and developing an effective management plan. We present a case report of linear porokeratosis and discuss aspects of etiology, diagnosis, and management. Read More

    Linear Malignant Melanoma In Situ: Reports and Review of Cutaneous Malignancies Presenting as Linear Skin Cancer.
    Cureus 2017 Sep 18;9(9):e1696. Epub 2017 Sep 18.
    Department of Dermatology, University of California, San Diego.
    Melanomas usually present as oval lesions in which the borders may be irregular. Other morphological features of melanoma include clinical asymmetry, variable color, diameter greater than 6 mm and evolving lesions. Two males whose melanoma in situ presented as linear skin lesions are described and cutaneous malignancies that may appear linear in morphology are summarized in this report. Read More

    Amelanotic melanoma arising within a lesion of disseminated superficial actinic porokeratosis: An unusual presentation leading to a novel therapeutic approach.
    Dermatol Ther 2018 Jan 4;31(1). Epub 2017 Oct 4.
    Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts.
    Disseminated superficial actinic porokeratosis (DSAP) is the most common variant of porokeratosis with a potential for malignant transformation. Its association with malignant melanoma, however, is exceedingly rare. Treatment of DSAP is often ineffective. Read More

    Clinical and Dermoscopic Features of Pigmented Disseminated Superficial Actinic Porokeratosis: Case Report and Literature Review.
    J Cutan Med Surg 2018 Mar/Apr;22(2):229-231. Epub 2017 Sep 18.
    1 Division of Dermatology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
    Introduction: Porokeratosis is a benign hyperkeratotic skin tumour due to a clonal proliferation of keratinocytes and is characterised by a telltale annular threadlike configuration along the border of a skin-colored to erythematous papule that can expand centrifugally.

    Case Presentation: We are presenting a clinical and dermoscopic case of pigmented disseminated superficial actinic porokeratosis (DSAP) limited to the upper trunk of a white man with sun-damaged skin. Literature Review and Conclusion: A thorough review of PubMed failed to identify any previous reports on the dermoscopic appearance of pigmented porokeratosis. Read More

    Enhanced dendritic cells and regulatory T cells in the dermis of porokeratosis.
    Arch Dermatol Res 2017 Nov 11;309(9):749-756. Epub 2017 Sep 11.
    Department of Dermatology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan.
    Porokeratosis is characterized clinically by annular lesions and histologically by the presence of a cornoid lamella (CL) in the epidermis. The underlying mechanism of porokeratosis development remains unclear. We performed immunohistochemical staining of CD1a, langerin, Ki67, CD3, CD4, CD8, FOXP3, and RANKL (receptor activator of nuclear factor κB ligand) in samples from 17 porokeratosis lesions and analyzed the differences in staining patterns among the CL, the inner part of the annular ridge (IC), and the adjacent normal skin (ANS). Read More

    Successful Use of Grenz Rays for Disseminated Superficial Actinic Porokeratosis: Report of 8 Cases.
    Dermatology 2017 18;233(2-3):217-222. Epub 2017 Aug 18.
    Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.
    Background: Disseminated superficial actinic porokeratosis (DSAP) is a rare keratinization disorder with potential malignant transformation, for which present treatment strategies show limited success.

    Aim: To evaluate the response of DSAP lesions to grenz ray radiotherapy (RTx).

    Methods: Data of patients treated with RTx at University Hospital Zurich, Switzerland, between 2004 and 2015, were reviewed. Read More

    [Analysis of clinical and genetic features of nine patients with disseminated superfacial actinic porokeratosis].
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2017 Aug;34(4):481-485
    Shanghai Clinical College of Skin Disease, Anhui Medical University, Shanghai 200443, China.
    Objective: To analyze the clinical and genetic features of 9 ethnic Han Chinese patients with disseminated superfacial actinic porokeratosis (DSAP).

    Methods: Genomic DNA was extracted from peripheral blood samples collected from the patients. PCR and direct sequencing were carried out for five patients from a family, 4 sporadic cases, and 120 healthy controls to identify potential mutations of four genes (MVK, MVD, PMVK, FDPS) involved in the mevalonate pathway as well as SLC17A9, SSH1, and SART3 genes. Read More

    Disorder of the mevalonate pathway inhibits calcium-induced differentiation of keratinocytes.
    Mol Med Rep 2017 Oct 1;16(4):4811-4816. Epub 2017 Aug 1.
    Department of Dermatology, Institute of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, P.R. China.
    Mutation of genes encoding the enzymes of the mevalonate pathway cause a variety of diseases, including skin disorders. Mutation of four genes in this pathway, including mevalonate kinase, phosphomevalonate kinase, mevalonate diphosphate decarboxylase and farnesyl diphosphate synthase, have demonstrated to be responsible for porokeratosis (PK). However, the pathogenesis of PK remains unclear. Read More

    Follicular porokeratosis: four new cases.
    Clin Exp Dermatol 2017 Dec 27;42(8):881-886. Epub 2017 Jul 27.
    Department of Cellular Pathology, Warwick Hospital, Warwick, Warwickshire, UK.
    Porokeratosis, a disorder of keratinisation, is clinically characterized by the presence of annular plaques with a surrounding keratotic ridge. Clinical variants include linear, disseminated superficial actinic, verrucous/hypertrophic, disseminated eruptive, palmoplantar and porokeratosis of Mibelli (one or two typical plaques with atrophic centre and guttered keratotic rim). All of these subtypes share the histological feature of a cornoid lamella, characterized by a column of 'stacked' parakeratosis with focal absence of the granular layer, and dysmaturation (prematurely keratinised cells in the upper spinous layer). Read More

    Onychodystrophy due to porokeratosis of Mibelli: a rare association.
    Acta Dermatovenerol Alp Pannonica Adriat 2017 Jun;26(2):51-52
    Advanced Skin Clinic, Nashik, Maharashtra, India.
    Porokeratosis is a specific keratinization disorder that manifests clinically as well-demarcated annular or linear keratotic plaques of various sizes and forms and with distinguished histology showing cornoid lamella, which is a column of closely packed parakeratotic cells extending through the stratum corneum. Nail changes secondary to porokeratotic lesions involving digits are quite uncommon and rarely reported in the porokeratosis of Mibelli (PM) subtype. Here we report the case of a young girl with a PM lesion over the hand along with nail dystrophy of the involved digit. Read More

    Porokeratosis ptychotropica responding to photodynamic therapy: An alternative treatment for a refractory disease.
    Photodermatol Photoimmunol Photomed 2017 Sep 20;33(5):271-274. Epub 2017 Jun 20.
    Department of Dermatology, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, Spain.
    Background: Porokeratosis ptychotropica (PP) is a rare variant of porokeratosis with a special predisposition to affect body folds, particularly the intergluteal cleft. This disease is resistant to most topical and systemic treatments, as shown in the review of the literature we provide here. Itching and discomfort are often a difficult problem to solve. Read More

    Disseminated superficial actinic porokeratosis treated with ingenol mebutate gel 0.05.
    Cutis 2017 Mar;99(3):E36-E39
    Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
    Disseminated superficial actinic porokeratosis (DSAP) is a chronic condition characterized by numerous atrophic papules and patches with a distinctive peripheral keratotic ridge, typically found on sun-exposed areas. Treatment of DSAP is warranted not only for cosmetic and symptomatic benefits but also to prevent malignant transformation. Successful treatment of DSAP often is difficult and frequently requires the use of multiple modalities. Read More

    Porokeratosis ptychotropica.
    An Bras Dermatol 2016 Sep-Oct;91(5 suppl 1):134-136
    Universidade de Santo Amaro (UNISA) - Santo Amaro (SP), Brazil.
    Porokeratosis is a skin disorder clinically characterized by annular plaques with keratotic borders resembling the Great Wall of China and histopathologically by cornoid lamellae. The disease has several clinical variants. Porokeratosis ptychotropica, which has recently become part of these variants, is quite rare and little known. Read More

    Porokeratosis of Mibelli in an HIV-positive patient.
    An Bras Dermatol 2016 Sep-Oct;91(5 suppl 1):131-133
    Hospital do Servidor Público Estadual de São Paulo (HSPE) - São Paulo (SP) - Brazil.
    Porokeratosis represents a group of disorders of epidermal keratinization that are characterized by one or more annular plaques surrounded by a histologically distinctive hyperkeratotic ridge-like border called the cornoid lamella. Many studies showed that organ transplantation and immunosuppression were associated in a significant number of cases. Furthermore, an association with squamous cell carcinoma and basal cell carcinoma has been noted in all variants of porokeratosis. Read More

    Porokeratosis simulating Bowen's disease on dermoscopy.
    An Bras Dermatol 2016 Sep-Oct;91(5 suppl 1):119-121
    Universidade de Pernambuco (UPE) - Recife (PE), Brazil.
    Porokeratosis is a disorder of epidermal keratinization characterized by the presence of annular hyperkeratotic plaques. Its etiopathogenesis is not yet fully understood, but a relationship with immunosuppression has been reported. Dermoscopic examination revealed a classic yellowish-white ring-like structure that resembled "volcanic crater contour" - the so-called cornoid lamella. Read More

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