1,119 results match your criteria Porokeratosis
Indian Dermatol Online J 2018 Nov-Dec;9(6):469-470
Department of Dermatology, Sri Dharmasthala Manjunatheshwara College of Medical Sciences and Hospital, Dharwad, Karnataka, India.
Actas Dermosifiliogr 2018 Nov 5. Epub 2018 Nov 5.
Programa de Dermatopatología, Universidad CES, Medellín, Antioquia, Colombia.
JAAD Case Rep 2018 Nov 29;4(10):972-975. Epub 2018 Oct 29.
Department of Dermatology, University of Massachusetts Medical School, UMass Memorial Healthcare, Worcester, Massachusetts.
Acta Derm Venereol 2018 Oct 17. Epub 2018 Oct 17.
Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100730 Beijing, China.
J Dermatol 2018 Sep 28. Epub 2018 Sep 28.
Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
J Cutan Pathol 2018 Dec 4;45(12):968-969. Epub 2018 Oct 4.
Department of Dermatology, Columbia University Medical Center, New York, New York.
Photodiagnosis Photodyn Ther 2018 09 1;23:365-366. Epub 2018 Aug 1.
University General Hospital of Valencia, Valencia, Spain.
G Ital Dermatol Venereol 2018 Jul 10. Epub 2018 Jul 10.
Dermatopathological Laboratory, San Gallicano Institute of Rome, Rome, Italy.
An Bras Dermatol 2018 Jun;93(3):477-478
Dermatology Unit, Hospital El Pino, Universidad de Santiago de Chile, San Bernardo, Chile.
Clin Cosmet Investig Dermatol 2018 1;11:219-229. Epub 2018 May 1.
Department of Dermatology, Mumbai Port Trust Hospital, Mumbai, India.
Porokeratosis is an uncommon disorder of keratinization that presents with keratotic papules or annular plaques that expand centrifugally with a thread-like elevated border. A distinctive histologic structure, the cornoid lamella, is diagnostic of this disorder and consists of a column of parakeratosis with the absence of the granular layer and dyskeratotic cells in the upper spinous zone. Porokeratosis confined to the genitogluteal region is rare and may be subclassified into three types, namely, classical porokeratosis on the genital region, ptychotropic porokeratosis most often seen in the natal cleft and buttocks and penoscrotal porokeratosis that is seen on the penis and adjacent scrotal skin in young men in their third decade of life. Read More
J Dermatol 2018 Jul 3;45(7):862-866. Epub 2018 May 3.
The Research Center for Medical Genomics, Key Laboratory of Cell Biology, Ministry of Public Health, Key Laboratory of Medical Cell Biology, Ministry of Education, College of Basic Medical Science, China Medical University, Shenyang, China.
Porokeratosis comprises heterogeneous keratinization disorders that are characterized by one or more atrophic patches surrounded by a ridge-like cornoid lamella. In this study, we evaluated seven families affected by porokeratosis and five sporadic patients of the disease in a Chinese population. We performed Sanger sequencing of exons and flanking intron-exon boundaries of mevalonate pathway genes (MVD, MVK, PMVK and FDPS) and of SLC17A9. Read More
Semin Cutan Med Surg 2018 Mar;37(1):75-80
Pathology and Dermatology, UCSF Dermatopathology and Oral Pathology Service, University of California, San Francisco, San Francisco, California, USA.
Dermatopathology reporting can be both exact and inexact. Exact reporting represents the use of terminology that corresponds to a disease sui generis, such as discoid lupus erythematosus or disseminated superficial porokeratosis. Inexact reporting can vary greatly amongst various practitioners-both in terms of the exact semantics used and also stylistically-and can be used habitually by pathologists as a means to provide cover for diagnostic uncertainty or inexperience. Read More
J Eur Acad Dermatol Venereol 2018 Nov 24;32(11):e419-e421. Epub 2018 May 24.
Department of Dermatology, Venereology and Leprology, Level 2, Nehru Hospital, Postgraduate Institute of Medical Education and Research, Sector 12, Chandigarh, 160012, India.
JAAD Case Rep 2018 May 1;4(4):340-343. Epub 2018 Apr 1.
Department of Dermatology & Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida.
Dermatol Online J 2018 Mar 15;24(3). Epub 2018 Mar 15.
Department of Internal Medicine, Division of Dermatology, The Ohio State University Wexner Medical Center, Gahanna, Ohio.
We report a case of temozolomide (TMZ)-induced inflammation of disseminated superficial actinic porokeratosis (DSAP), an uncommon and pre-malignant cutaneous disorder. Dermatologists and oncologists should be aware of this cutaneous eruption of DSAP associated with TMZ to prevent the discontinuation of effective medical therapy in cancer patients. Read More
Dermatol Online J 2018 Mar 15;24(3). Epub 2018 Mar 15.
Department of Dermatology, University of California San Diego, La Jolla, California.
Genitogluteal porokeratosis is a disorder of keratinization that may present in men in their fourth decade of life. We describe a 52-year-old human immunodeficiency virus (HIV)-positive man with history of anal squamous cell carcinoma who developed verrucous lesions on the buttocks and genitals. The buttock lesions presented shortly after radiotherapy for anal carcinoma a decade prior, whereas the genital lesions presented three months prior in areas treated with injectable medication for erectile dysfunction. Read More
Dermatol Online J 2018 Feb 15;24(2). Epub 2018 Feb 15.
Department of Medicine, St Vincent's Hospital, Melbourne, Victoria, Australia,.
Disseminated superficial actinic porokeratosis (DSAP) is an inherited dermatosis triggered by chronic ultraviolet light exposure. Cosmetic improvement has been noted with topical therapies or laser treatment. Lesions of DSAP are precancerous, having been reported to develop into squamous cell carcinomas (SCCs) or basal cell carcinomas (BCCs) occasionally. Read More
Ann Dermatol 2018 Apr 21;30(2):249-251. Epub 2018 Feb 21.
Department of Dermatology, College of Medicine, Kyung Hee University, Seoul, Korea.
Ann Dermatol 2018 Apr 21;30(2):211-213. Epub 2018 Feb 21.
Department of Dermatology, Soonchunhyang University Bucheon Hospital, Bucheon, Korea.
Porokeratosis is a rare epidermal disorder characterized by annular or linear hyperkeratotic plaques with slightly raised thread-like borders, and in most cases, atrophic centers. Disseminated superficial porokeratosis and disseminated superficial actinic porokeratosis (DSAP), which primarily involve sun-exposed areas, are common types of porokeratoses. Histologically, a column of parakeratotic cells, a so-called cornoid lamella, is a hallmark of porokeratosis. Read More
Open Access Maced J Med Sci 2018 Jan 13;6(1):139-142. Epub 2018 Jan 13.
"Onkoderma"- Policlinic for Dermatology and Dermatologic Surgery, Sofia, Bulgaria.
Background: Porokeratosis is characterised by one or more atrophic patches surrounded by a distinctive peripheral keratotic ridge, typically found on sun-exposed areas, with several clinical variants and typical histological findings. Despite ultraviolet radiation, varies antibody - related autoimmune disease treated with systemic steroids and other immunosuppressive conditions such as chronic liver disease, HIV and organ transplantations have been implicated in its etiopathology.
Case Report: We present a case of porokeratosis, associated with idiopathic thrombocytopenia in 74 - year old, otherwise healthy male patient, as we discuss the previously reported associated disorders. Read More
Pediatr Dermatol 2018 Mar 16;35(2):e103-e104. Epub 2018 Jan 16.
Department of Dermatology, University of California, San Diego, La Jolla, CA, USA.
We present what we believe to be the second case of pediatric penile porokeratosis and the youngest case reported. A 6-year-old boy presented with a pruritic, verrucous growth at the urethral meatus that recurred after two meatotomies. The diagnosis of porokeratosis was confirmed by biopsy. Read More
Dermatol Surg 2018 Apr;44(4):580-581
Division of Dermatology, University of Louisville, Louisville, Kentucky.
Indian J Dermatol Venereol Leprol 2018 Jan-Feb;84(1):81-82
Department of Dermatology, Sri Manakula Vinayagar Medical College and Hospital, Puducherry, India.
An Bras Dermatol 2017 ;92(5 Suppl 1):121-125
Department of Dermatology, Complejo Hospitalario de Navarra - Pamplona, Spain.
Porokeratotic eccrine and hair follicle nevus is a very rare non-hereditary disorder of keratinization with eccrine and hair follicle involvement with only 9 cases described in the literature. In 2009 the term porokeratotic anexial ostial nevus was proposed to comprehend porokeratotic eccrine and hair follicle nevus and a related and more common process without follicular involvement: porokeratotic eccrine ostial and dermal duct nevus Recent findings suggest that both entities may be produced by a mutation in GJB2 gene, which is associated to KID syndrome. Herein we report 2 cases of porokeratotic eccrine and hair follicle nevus and review the existing cases in the Spanish and English literature. Read More
Acta Dermatovenerol Alp Pannonica Adriat 2017 Dec;26(4):113-114
Department of Dermatology, Dr. Vasantrao Pawar Medical College, Hospital and Research Center, Nashik, Maharashtra, India.
Since its description in 1995, porokeratosis ptychotropica (PP) has remained a less-recognized variant of porokeratosis (PK). The term porokeratosis ptychotropica was coined in reference to its characteristic of affecting body folds. It mimics many other dermatological diseases and is therefore often misdiagnosed. Read More
Cutis 2017 Nov;100(5):E11-E14
Department of Dermatology, University of Pittsburgh, Pennsylvania, USA.
Linear porokeratosis is a rare subtype of porokeratosis with a higher rate of malignant transformation than other subtypes of porokeratosis. Identification of cornoid lamellae on histology allows for definitive diagnosis, which makes high clinical suspicion and appropriate biopsy essential in establishing the correct diagnosis and developing an effective management plan. We present a case report of linear porokeratosis and discuss aspects of etiology, diagnosis, and management. Read More
Int J Dermatol 2018 02 12;57(2):e7-e9. Epub 2017 Dec 12.
Research and Clinical Center for Yusho and Dioxin, Kyushu University Hospital, Fukuoka, Japan.
J Am Acad Dermatol 2017 Dec 6. Epub 2017 Dec 6.
Dermatology Service, Memorial Sloan Kettering Cancer Center, Hauppauge, NY, USA. Electronic address:
Actas Dermosifiliogr 2018 Jul - Aug;109(6):559-560. Epub 2017 Dec 6.
Unidad de Dermatología, Inselspital, Hospital Universitario de Berna, Berna, Suiza.
J Eur Acad Dermatol Venereol 2018 May 18;32(5):e201-e202. Epub 2017 Dec 18.
Department of Dermatology, Sapporo City General Hospital, North 11, West 13, Chuo-Ku, Sapporo, Hokkaido, 060-8604, Japan.
Cureus 2017 Sep 18;9(9):e1696. Epub 2017 Sep 18.
Department of Dermatology, University of California, San Diego.
Melanomas usually present as oval lesions in which the borders may be irregular. Other morphological features of melanoma include clinical asymmetry, variable color, diameter greater than 6 mm and evolving lesions. Two males whose melanoma in situ presented as linear skin lesions are described and cutaneous malignancies that may appear linear in morphology are summarized in this report. Read More
Br J Dermatol 2017 10;177(4):e159
Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Dermatol Ther 2018 Jan 4;31(1). Epub 2017 Oct 4.
Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts.
Disseminated superficial actinic porokeratosis (DSAP) is the most common variant of porokeratosis with a potential for malignant transformation. Its association with malignant melanoma, however, is exceedingly rare. Treatment of DSAP is often ineffective. Read More
J Eur Acad Dermatol Venereol 2018 Mar 10;32(3):e114-e115. Epub 2017 Oct 10.
Department of Dermatology, Instituto Mexicano del Cuidado Avanzado de Heridas, Mexico City, Mexico.
J Cutan Med Surg 2018 Mar/Apr;22(2):229-231. Epub 2017 Sep 18.
1 Division of Dermatology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Introduction: Porokeratosis is a benign hyperkeratotic skin tumour due to a clonal proliferation of keratinocytes and is characterised by a telltale annular threadlike configuration along the border of a skin-colored to erythematous papule that can expand centrifugally.
Case Presentation: We are presenting a clinical and dermoscopic case of pigmented disseminated superficial actinic porokeratosis (DSAP) limited to the upper trunk of a white man with sun-damaged skin. Literature Review and Conclusion: A thorough review of PubMed failed to identify any previous reports on the dermoscopic appearance of pigmented porokeratosis. Read More
G Ital Dermatol Venereol 2017 10;152(5):533-534
Department of Dermatology, A. Cardarelli Hospital, Naples, Italy.
Arch Dermatol Res 2017 Nov 11;309(9):749-756. Epub 2017 Sep 11.
Department of Dermatology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan.
Porokeratosis is characterized clinically by annular lesions and histologically by the presence of a cornoid lamella (CL) in the epidermis. The underlying mechanism of porokeratosis development remains unclear. We performed immunohistochemical staining of CD1a, langerin, Ki67, CD3, CD4, CD8, FOXP3, and RANKL (receptor activator of nuclear factor κB ligand) in samples from 17 porokeratosis lesions and analyzed the differences in staining patterns among the CL, the inner part of the annular ridge (IC), and the adjacent normal skin (ANS). Read More
Indian Pediatr 2017 08;54(8):698
Departments of Dermatology and #Pathology, Farhat Hached Hospital, Tunisia.
Dermatology 2017 18;233(2-3):217-222. Epub 2017 Aug 18.
Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.
Background: Disseminated superficial actinic porokeratosis (DSAP) is a rare keratinization disorder with potential malignant transformation, for which present treatment strategies show limited success.
Aim: To evaluate the response of DSAP lesions to grenz ray radiotherapy (RTx).
Methods: Data of patients treated with RTx at University Hospital Zurich, Switzerland, between 2004 and 2015, were reviewed. Read More
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2017 Aug;34(4):481-485
Shanghai Clinical College of Skin Disease, Anhui Medical University, Shanghai 200443, China.
Objective: To analyze the clinical and genetic features of 9 ethnic Han Chinese patients with disseminated superfacial actinic porokeratosis (DSAP).
Methods: Genomic DNA was extracted from peripheral blood samples collected from the patients. PCR and direct sequencing were carried out for five patients from a family, 4 sporadic cases, and 120 healthy controls to identify potential mutations of four genes (MVK, MVD, PMVK, FDPS) involved in the mevalonate pathway as well as SLC17A9, SSH1, and SART3 genes. Read More
Mol Med Rep 2017 Oct 1;16(4):4811-4816. Epub 2017 Aug 1.
Department of Dermatology, Institute of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, P.R. China.
Mutation of genes encoding the enzymes of the mevalonate pathway cause a variety of diseases, including skin disorders. Mutation of four genes in this pathway, including mevalonate kinase, phosphomevalonate kinase, mevalonate diphosphate decarboxylase and farnesyl diphosphate synthase, have demonstrated to be responsible for porokeratosis (PK). However, the pathogenesis of PK remains unclear. Read More
Indian Dermatol Online J 2017 Jul-Aug;8(4):304-305
First Department of Dermatology, Aristotle University, Thessaloniki, Greece.
Ann Dermatol 2017 Aug 21;29(4):506-508. Epub 2017 Jun 21.
Department of Dermatology, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju, Korea.
Clin Exp Dermatol 2017 Dec 27;42(8):881-886. Epub 2017 Jul 27.
Department of Cellular Pathology, Warwick Hospital, Warwick, Warwickshire, UK.
Porokeratosis, a disorder of keratinisation, is clinically characterized by the presence of annular plaques with a surrounding keratotic ridge. Clinical variants include linear, disseminated superficial actinic, verrucous/hypertrophic, disseminated eruptive, palmoplantar and porokeratosis of Mibelli (one or two typical plaques with atrophic centre and guttered keratotic rim). All of these subtypes share the histological feature of a cornoid lamella, characterized by a column of 'stacked' parakeratosis with focal absence of the granular layer, and dysmaturation (prematurely keratinised cells in the upper spinous layer). Read More
Clin Exp Dermatol 2017 Dec 24;42(8):910-911. Epub 2017 Jul 24.
Department of Dermatology, Huashan Hospital, Shanghai Medical College of Fudan University, Shanghai, China.
J Cutan Pathol 2017 09 14;44(9):813-814. Epub 2017 Jul 14.
Department of Pathology, Albany Medical College, Albany, New York.
Chin Med J (Engl) 2017 Jul;130(14):1747-1748
Department of Dermatology and Venereology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.