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    1094 results match your criteria Porokeratosis

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    Pediatric penile porokeratosis: A case report.
    Pediatr Dermatol 2018 Jan 16. Epub 2018 Jan 16.
    Department of Dermatology, University of California, San Diego, La Jolla, CA, USA.
    We present what we believe to be the second case of pediatric penile porokeratosis and the youngest case reported. A 6-year-old boy presented with a pruritic, verrucous growth at the urethral meatus that recurred after two meatotomies. The diagnosis of porokeratosis was confirmed by biopsy. Read More

    Hyperkeratotic porokeratosis ptychotropica with satellite lesions: a rare presentation of an unusual variant of porokeratosis.
    Acta Dermatovenerol Alp Pannonica Adriat 2017 Dec;26(4):113-114
    Department of Dermatology, Dr. Vasantrao Pawar Medical College, Hospital and Research Center, Nashik, Maharashtra, India.
    Since its description in 1995, porokeratosis ptychotropica (PP) has remained a less-recognized variant of porokeratosis (PK). The term porokeratosis ptychotropica was coined in reference to its characteristic of affecting body folds. It mimics many other dermatological diseases and is therefore often misdiagnosed. Read More

    Linear porokeratosis associated with multiple squamous cell carcinomas.
    Cutis 2017 Nov;100(5):E11-E14
    Department of Dermatology, University of Pittsburgh, Pennsylvania, USA.
    Linear porokeratosis is a rare subtype of porokeratosis with a higher rate of malignant transformation than other subtypes of porokeratosis. Identification of cornoid lamellae on histology allows for definitive diagnosis, which makes high clinical suspicion and appropriate biopsy essential in establishing the correct diagnosis and developing an effective management plan. We present a case report of linear porokeratosis and discuss aspects of etiology, diagnosis, and management. Read More

    Linear Malignant Melanoma In Situ: Reports and Review of Cutaneous Malignancies Presenting as Linear Skin Cancer.
    Cureus 2017 Sep 18;9(9):e1696. Epub 2017 Sep 18.
    Department of Dermatology, University of California, San Diego.
    Melanomas usually present as oval lesions in which the borders may be irregular. Other morphological features of melanoma include clinical asymmetry, variable color, diameter greater than 6 mm and evolving lesions. Two males whose melanoma in situ presented as linear skin lesions are described and cutaneous malignancies that may appear linear in morphology are summarized in this report. Read More

    Amelanotic melanoma arising within a lesion of disseminated superficial actinic porokeratosis: An unusual presentation leading to a novel therapeutic approach.
    Dermatol Ther 2018 Jan 4;31(1). Epub 2017 Oct 4.
    Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts.
    Disseminated superficial actinic porokeratosis (DSAP) is the most common variant of porokeratosis with a potential for malignant transformation. Its association with malignant melanoma, however, is exceedingly rare. Treatment of DSAP is often ineffective. Read More

    Clinical and Dermoscopic Features of Pigmented Disseminated Superficial Actinic Porokeratosis: Case Report and Literature Review.
    J Cutan Med Surg 2017 Sep 1:1203475417733465. Epub 2017 Sep 1.
    1 Division of Dermatology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
    Introduction: Porokeratosis is a benign hyperkeratotic skin tumour due to a clonal proliferation of keratinocytes and is characterised by a telltale annular threadlike configuration along the border of a skin-colored to erythematous papule that can expand centrifugally.

    Case Presentation: We are presenting a clinical and dermoscopic case of pigmented disseminated superficial actinic porokeratosis (DSAP) limited to the upper trunk of a white man with sun-damaged skin. Literature Review and Conclusion: A thorough review of PubMed failed to identify any previous reports on the dermoscopic appearance of pigmented porokeratosis. Read More

    Enhanced dendritic cells and regulatory T cells in the dermis of porokeratosis.
    Arch Dermatol Res 2017 Nov 11;309(9):749-756. Epub 2017 Sep 11.
    Department of Dermatology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan.
    Porokeratosis is characterized clinically by annular lesions and histologically by the presence of a cornoid lamella (CL) in the epidermis. The underlying mechanism of porokeratosis development remains unclear. We performed immunohistochemical staining of CD1a, langerin, Ki67, CD3, CD4, CD8, FOXP3, and RANKL (receptor activator of nuclear factor κB ligand) in samples from 17 porokeratosis lesions and analyzed the differences in staining patterns among the CL, the inner part of the annular ridge (IC), and the adjacent normal skin (ANS). Read More

    Successful Use of Grenz Rays for Disseminated Superficial Actinic Porokeratosis: Report of 8 Cases.
    Dermatology 2017 18;233(2-3):217-222. Epub 2017 Aug 18.
    Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.
    Background: Disseminated superficial actinic porokeratosis (DSAP) is a rare keratinization disorder with potential malignant transformation, for which present treatment strategies show limited success.

    Aim: To evaluate the response of DSAP lesions to grenz ray radiotherapy (RTx).

    Methods: Data of patients treated with RTx at University Hospital Zurich, Switzerland, between 2004 and 2015, were reviewed. Read More

    [Analysis of clinical and genetic features of nine patients with disseminated superfacial actinic porokeratosis].
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2017 Aug;34(4):481-485
    Shanghai Clinical College of Skin Disease, Anhui Medical University, Shanghai 200443, China.
    Objective: To analyze the clinical and genetic features of 9 ethnic Han Chinese patients with disseminated superfacial actinic porokeratosis (DSAP).

    Methods: Genomic DNA was extracted from peripheral blood samples collected from the patients. PCR and direct sequencing were carried out for five patients from a family, 4 sporadic cases, and 120 healthy controls to identify potential mutations of four genes (MVK, MVD, PMVK, FDPS) involved in the mevalonate pathway as well as SLC17A9, SSH1, and SART3 genes. Read More

    Disorder of the mevalonate pathway inhibits calcium-induced differentiation of keratinocytes.
    Mol Med Rep 2017 Oct 1;16(4):4811-4816. Epub 2017 Aug 1.
    Department of Dermatology, Institute of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, P.R. China.
    Mutation of genes encoding the enzymes of the mevalonate pathway cause a variety of diseases, including skin disorders. Mutation of four genes in this pathway, including mevalonate kinase, phosphomevalonate kinase, mevalonate diphosphate decarboxylase and farnesyl diphosphate synthase, have demonstrated to be responsible for porokeratosis (PK). However, the pathogenesis of PK remains unclear. Read More

    Follicular porokeratosis: four new cases.
    Clin Exp Dermatol 2017 Dec 27;42(8):881-886. Epub 2017 Jul 27.
    Department of Cellular Pathology, Warwick Hospital, Warwick, Warwickshire, UK.
    Porokeratosis, a disorder of keratinisation, is clinically characterized by the presence of annular plaques with a surrounding keratotic ridge. Clinical variants include linear, disseminated superficial actinic, verrucous/hypertrophic, disseminated eruptive, palmoplantar and porokeratosis of Mibelli (one or two typical plaques with atrophic centre and guttered keratotic rim). All of these subtypes share the histological feature of a cornoid lamella, characterized by a column of 'stacked' parakeratosis with focal absence of the granular layer, and dysmaturation (prematurely keratinised cells in the upper spinous layer). Read More

    Onychodystrophy due to porokeratosis of Mibelli: a rare association.
    Acta Dermatovenerol Alp Pannonica Adriat 2017 Jun;26(2):51-52
    Advanced Skin Clinic, Nashik, Maharashtra, India.
    Porokeratosis is a specific keratinization disorder that manifests clinically as well-demarcated annular or linear keratotic plaques of various sizes and forms and with distinguished histology showing cornoid lamella, which is a column of closely packed parakeratotic cells extending through the stratum corneum. Nail changes secondary to porokeratotic lesions involving digits are quite uncommon and rarely reported in the porokeratosis of Mibelli (PM) subtype. Here we report the case of a young girl with a PM lesion over the hand along with nail dystrophy of the involved digit. Read More

    Porokeratosis ptychotropica responding to photodynamic therapy: An alternative treatment for a refractory disease.
    Photodermatol Photoimmunol Photomed 2017 Sep 20;33(5):271-274. Epub 2017 Jun 20.
    Department of Dermatology, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, Spain.
    Background: Porokeratosis ptychotropica (PP) is a rare variant of porokeratosis with a special predisposition to affect body folds, particularly the intergluteal cleft. This disease is resistant to most topical and systemic treatments, as shown in the review of the literature we provide here. Itching and discomfort are often a difficult problem to solve. Read More

    Disseminated superficial actinic porokeratosis treated with ingenol mebutate gel 0.05.
    Cutis 2017 Mar;99(3):E36-E39
    Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
    Disseminated superficial actinic porokeratosis (DSAP) is a chronic condition characterized by numerous atrophic papules and patches with a distinctive peripheral keratotic ridge, typically found on sun-exposed areas. Treatment of DSAP is warranted not only for cosmetic and symptomatic benefits but also to prevent malignant transformation. Successful treatment of DSAP often is difficult and frequently requires the use of multiple modalities. Read More

    Porokeratosis ptychotropica.
    An Bras Dermatol 2016 Sep-Oct;91(5 suppl 1):134-136
    Universidade de Santo Amaro (UNISA) - Santo Amaro (SP), Brazil.
    Porokeratosis is a skin disorder clinically characterized by annular plaques with keratotic borders resembling the Great Wall of China and histopathologically by cornoid lamellae. The disease has several clinical variants. Porokeratosis ptychotropica, which has recently become part of these variants, is quite rare and little known. Read More

    Porokeratosis of Mibelli in an HIV-positive patient.
    An Bras Dermatol 2016 Sep-Oct;91(5 suppl 1):131-133
    Hospital do Servidor Público Estadual de São Paulo (HSPE) - São Paulo (SP) - Brazil.
    Porokeratosis represents a group of disorders of epidermal keratinization that are characterized by one or more annular plaques surrounded by a histologically distinctive hyperkeratotic ridge-like border called the cornoid lamella. Many studies showed that organ transplantation and immunosuppression were associated in a significant number of cases. Furthermore, an association with squamous cell carcinoma and basal cell carcinoma has been noted in all variants of porokeratosis. Read More

    Porokeratosis simulating Bowen's disease on dermoscopy.
    An Bras Dermatol 2016 Sep-Oct;91(5 suppl 1):119-121
    Universidade de Pernambuco (UPE) - Recife (PE), Brazil.
    Porokeratosis is a disorder of epidermal keratinization characterized by the presence of annular hyperkeratotic plaques. Its etiopathogenesis is not yet fully understood, but a relationship with immunosuppression has been reported. Dermoscopic examination revealed a classic yellowish-white ring-like structure that resembled "volcanic crater contour" - the so-called cornoid lamella. Read More

    Treatment of Porokeratosis: A Systematic Review.
    Am J Clin Dermatol 2017 Aug;18(4):435-449
    Department of Dermatology, University Hospital Jena, Erfurter Straße 35, 07743, Jena, Germany.
    Background: Porokeratosis (PK) is a rare skin disease of unknown etiology. It consists of a keratinization disorder, which may appear in several clinical forms and can undergo malignant transformation. The histopathological hallmark of PK is the cornoid lamella. Read More

    Follicular Porokeratosis, a Porokeratosis Variant.
    Am J Dermatopathol 2017 Aug;39(8):e107-e109
    *Department of Dermatopathology, Pathlab Bay of Plenty, Tauranga, New Zealand; †Skin Dermatology Institute, Tauranga, New Zealand; and ‡Department of Pathology and Molecular Medicine, University of Auckland.
    Porokeratosis derives from a process of abnormal keratinization, resulting in clinical and histologic variants. Follicular involvement is infrequently described, with previous suggestions that it may represent a distinct condition. We describe a case of typical disseminated superficial actinic porokeratosis with additional clinically prominent folliculocentric keratosis. Read More

    Light and laser treatment modalities for disseminated superficial actinic porokeratosis: a systematic review.
    Lasers Med Sci 2017 May 27;32(4):945-952. Epub 2017 Feb 27.
    Division of Dermatology, Creighton University School of Medicine, Omaha, NE, USA.
    Treatment of disseminated superficial actinic porokeratosis (DSAP) is poorly standardized. The present review seeks to comprehensively discuss the potential for laser and light modalities in the treatment of DSAP. A systematic review of light and laser treatment modalities was conducted to include 26 cases of patients with DSAP. Read More

    Secondary Cutaneous Amyloidosis in a Patient with Mycosis Fungoides.
    Ann Dermatol 2017 Feb 3;29(1):79-82. Epub 2017 Feb 3.
    Department of Dermatology, Dankook University Medical College, Cheonan, Korea.
    Secondary cutaneous amyloidosis refers to clinically unapparent amyloid deposits within the skin in association with a pre-existing skin condition or skin tumors, such as basal cell carcinoma, porokeratosis, solar elastosis, Bowen's disease, and mycosis fungoides. A 70-year-old woman presented with a 6-month history of asymptomatic multiple yellowish plaques on both legs. She had been diagnosed with mycosis fungoides 7 years ago and was treated with psoralen and ultraviolet A radiation (PUVA) therapy, narrow-band ultraviolet B (UVB) therapy, and acitretin for 5 years. Read More

    Craniosynostosis, delayed closure of the fontanelle, anal, genitourinary, and skin abnormalities (CDAGS syndrome): first report in a Mexican patient and review of the literature.
    Int J Dermatol 2017 Apr 19;56(4):435-439. Epub 2017 Feb 19.
    Department of Dermatology, Hospital Infantil de México Federico Gómez, México, D.F, Mexico.
    Introduction: Craniosynostosis and clavicular hypoplasia, delayed closure of the fontanelle, cranial defects, anal and genitourinary abnormalities, and skin (CDAGS), is an infrequent autosomal recessive entity with only 10 cases reported; no associated gene has been identified so far.

    Case Report: The proband is a 2-year-old Mexican female with brachycephaly, cleft palate, anal malformation with rectovestibular fistula, and clinodactyly of the third toe overlapping the second. At 4 months of age, she developed a disseminated dermatosis with erythematous scaly nummular plaques, elevated keratotic sharp borders with thin to broad flaking, hematic crusts, and keratotic surface in others. Read More

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