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Comput Biol Med 2022 Jul 21;146:105653. Epub 2022 May 21.

Department of Chest Diseases, Faculty of Medicine, Yuksek Ihtisas University, Ankara, Turkey.

Sleep staging is one of the most important parts of sleep assessment and it has an important role in early diagnosis and intervention of sleep disorders. Manual sleep staging requires a specialist and time which can be affected by subjective factors. So that, automatic sleep-scoring method with high accuracy is beneficial. Read More

J Neurol 2022 Jun 24. Epub 2022 Jun 24.

Wicking Dementia Research and Education Centre, University of Tasmania, Hobart, Australia.

Isolated REM sleep behaviour disorder (iRBD) is characterised by dream enactment behaviours, such as kicking and punching while asleep, and vivid/violent dreams. It is now acknowledged as a prodromal phase of neurodegenerative disease-approximately 80% of people with iRBD will develop dementia with Lewy Bodies, Parkinson's disease or another degenerative brain disease within 10 years. It is important that neurologists and other clinicians understand how to make an early accurate diagnosis of iRBD so that affected people can have the opportunity to take part in clinical trials. Read More

Physiol Rep 2022 Jun;10(12):e15360

University of California, Division of Pulmonary, Critical Care, Sleep Medicine, and Physiology, La Jolla, California, USA.

There is a need for alternatives to positive airway pressure for the treatment of obstructive sleep apnea and snoring. Improving upper airway dilator function might alleviate upper airway obstruction. We hypothesized that transoral neuromuscular stimulation would reduce upper airway collapse in concert with improvement in genioglossal muscle function. Read More

Cureus 2022 May 23;14(5):e25230. Epub 2022 May 23.

Department of Pulmonary Medicine, National Institute of Tuberculosis and Respiratory Diseases, New Delhi, IND.

Sleep-disordered breathing (SDB) is highly prevalent in patients with cancer and affects their prognosis. However, data on SDB in lung cancer patients are lacking, and few studies have conducted level I polysomnography (PSG) in this patient population. This study aimed to measure SDB in newly diagnosed lung cancer patients at the sleep clinic of a tertiary respiratory institute in New Delhi, India, for eight months. Read More

Medicina (Kaunas) 2022 Jun 9;58(6). Epub 2022 Jun 9.

Honeynaps Research and Development Center, Honeynaps Co., Ltd., 4F, 529, Nonhyeon-ro, Gangnam-gu, Seoul 06126, Korea.

Polysomnography is manually scored by sleep experts. However, manual scoring is a time-consuming and labor-intensive task. The goal of this study was to verify the accuracy of automated sleep-stage scoring based on a deep learning algorithm compared to manual sleep-stage scoring. Read More

J Pers Med 2022 Jun 16;12(6). Epub 2022 Jun 16.

First Department of Psychiatry, National and Kapodistrian University of Athens Medical School, Eginition Hospital, 11528 Athens, Greece.

Obstructive sleep apnea (OSA) is a rising problem, with important implications for public health. Recent evidence has revealed a link between OSA and reduced male fertility. We investigated the association between OSA and sexual and erectile function, as well as semen quality, and the effect of treatment by continuous positive airway pressure (CPAP). Read More

Healthcare (Basel) 2022 Jun 6;10(6). Epub 2022 Jun 6.

Department of Clinical Therapeutics, Division of Pulmonology, National and Kapodistrian University of Athens School of Medicine, Alexandra Hospital, 11528 Athens, Greece.

This is a case description of a patient with previously diagnosed rapid eye movement sleep behavior disorder (RBD) and nocturnal enuresis, who complained about a "peculiar sound" while sleeping and, occasionally, while awake during intensive exercise, for the last three months. A home audio recording, which his wife obtained while he was sleeping, showed a high-pitched sound identified as stridor. Full video polysomnography revealed no apneas or hypopneas. Read More

Children (Basel) 2022 Jun 17;9(6). Epub 2022 Jun 17.

Department of Pediatrics, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 23142, Taiwan.

Obstructive sleep apnea syndrome (OSAS) is one of the most common comorbidities in patients with Prader-Willi syndrome (PWS) and causes significant consequences. This observational study was conducted to investigate the progression of OSAS in pediatric patients with PWS, who had not undergone upper airway surgery, through a longitudinal follow-up of their annual polysomnography results. Annual body mass index (BMI), BMI z-score, sleep efficiency and stages, central apnea index (CAI), obstructive apnea-hypopnea index (OAHI), and oxygen saturation nadir values were longitudinally analyzed. Read More

JAMA Otolaryngol Head Neck Surg 2022 Jun 23. Epub 2022 Jun 23.

Department of Otorhinolaryngology-Head and Neck Surgery, University of Maryland School of Medicine, Baltimore.

Importance: Adenotonsillectomy, performed for approximately 500 000 children annually in the US alone, is the first line of treatment of pediatric obstructive sleep apnea (OSA). The Childhood Adenotonsillectomy Trial (CHAT), the first randomized clinical trial to test the efficacy of adenotonsillectomy, compared the management of pediatric nonsevere OSA by early adenotonsillectomy (eAT) vs watchful waiting with supportive care. Since the publication of the primary article in 2013, the CHAT study data set were made available via the National Sleep Research Resource, which allowed researchers to address a range of additional clinical questions relevant to the care of children with OSA. Read More

Dent J (Basel) 2022 Jun 6;10(6). Epub 2022 Jun 6.

Department of Human Sciences, Innovation and Territory, Postgraduate School of Orthodontics, School of Dental Hygiene, University of Insubria, 22100 Como, Italy.

This study was conducted to determine the efficacy of a customized mandibular advancement device (MAD) in the treatment of obstructive sleep apnea (OSA). Eight patients (M = 3; F = 5; mean age = 56.3 ± 9. Read More

J Sleep Res 2022 Jun 22:e13673. Epub 2022 Jun 22.

Faculty of Medicine and health Sciences, University of Antwerp, Wilrijk, Belgium.

Mandibular advancement device (MAD) treatment outcome for obstructive sleep apnea (OSA) is variable and patient dependent. A global, clinically applicable predictive model is lacking. Our aim was to combine characteristics obtained during drug-induced sleep endoscopy (DISE), awake nasendoscopy, and computed tomography scan-based computational fluid dynamic (CFD) measurements in one multifactorial model, to explain MAD treatment outcome. Read More

Nat Sci Sleep 2022 16;14:1149-1164. Epub 2022 Jun 16.

School of Medicine, National Tsing Hua University, Hsinchu, Taiwan.

Background: Obstructive sleep apnea (OSA) and obesity are both directional risk factors of hypertension. Chronic intermittent hypoxemia (IH) is a commonly observed pathophysiological mechanism involved in multiple comorbidities of OSA. However, their interactions are not well understood in children. Read More

Nat Sci Sleep 2022 15;14:1137-1148. Epub 2022 Jun 15.

The University Sleep Disorders Center, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Purpose: No study has assessed the titration success of CPAP therapy in patients with obesity hypoventilation syndrome (OHS) and an apnea-hypopnea index (AHI) <30 event/h. This study aimed to assess the titration success of CPAP therapy under polysomnography and subsequent short-term adherence (1 month) in patients with OHS and an AHI <30 event/h.

Methods: Consecutive OHS patients with an AHI <30 events/h between 2010 and 2019 were included (n=54). Read More

J Clin Sleep Med 2022 Jun 23. Epub 2022 Jun 23.

Loewenstein Rehabilitation Medical Center, Raanana, Israel.

Narcolepsy is a rare condition in Israel. Currently, the incidence of narcolepsy following SARS-CoV-2 vaccination in Israel is unknown. We are reporting a case report of a 51-year-old female of Ashkenazi Jewish descent who was evaluated for complaints of excessive daytime sleepiness and relative functional decline that immediately followed receipt of the Pfizer/BioNTech SARS-CoV-2 vaccination. Read More

PLoS One 2022 22;17(6):e0269569. Epub 2022 Jun 22.

Department of Clinical Science, University of Bergen, Bergen, Norway.

Background: The prevalence of obstructive sleep apnea is higher in women after menopause. This is suggested to be a result of an altered sex hormone balance but has so far not been confirmed in a population-based study.

Objective: To investigate whether serum concentration of estrogens and progesterone are associated with the prevalence of sleep apnea symptoms in middle-aged women of the general population. Read More

Adv Respir Med 2022 ;90(2):156

Department of Pulmonary and Critical Care Medicine, Vardhman Mahavir Medical College and Safdarjung Hospital, Delhi, India.

J Biol Rhythms 2022 Jun 22:7487304221096910. Epub 2022 Jun 22.

Chronobiology Unit, Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, the Netherlands.

Under real-life conditions, increased light exposure during wakefulness seems associated with improved sleep quality, quantified as reduced time awake during bed time, increased time spent in non-rapid eye movement (NREM) sleep, or increased power of the electroencephalogram delta band (0.5-4 Hz). The causality of these important relationships and their dependency on circadian phase and/or time awake has not been studied in depth. Read More

J Plast Reconstr Aesthet Surg 2022 Apr 27. Epub 2022 Apr 27.

Department of Plastic & Reconstructive Surgery, Children's Health Ireland at Crumlin, Dublin, Ireland; Department of Surgery and Paediatrics, Trinity College Dublin, Ireland.

Velopharyngeal dysfunction (VPD) occurs when there is inadequate closure of the velopharyngeal sphincter during speech. An incompetent velopharyngeal sphincter may require surgical intervention to create a functional seal between the oropharynx and the nasopharynx during speech. To date, no single pharyngoplasty procedure has emerged as superior to another, and the comparison of results between studies has been limited by variation in outcomes reporting. Read More

Int J Pediatr Otorhinolaryngol 2022 Jun 14;159:111208. Epub 2022 Jun 14.

Department of Otorhinolaryngology-Head and Neck Surgery, Soonchunhyang University College of Medicine, Bucheon Hospital, Bucheon, Gyeonggi-do, Republic of Korea. Electronic address:

Objectives: This study aimed to identify the effectiveness of respiratory mechanic instability (RMI) in the diagnosis of pediatric obstructive sleep apnea syndrome (OSAS). We sought to evaluate the correlations of RMI with sleep-related parameters and determine the effectiveness of using RMI for diagnosing OSAS in children.

Methods: Children who underwent polysomnography (PSG) for various reasons were enrolled in this study. Read More

N Z Med J 2022 Apr 14;135(1553):62-71. Epub 2022 Apr 14.

Manager, WellSleep, Department of Medicine, University of Otago Wellington.

Aims: To document the establishment of a Paediatric Continuous Positive Airway Pressure (CPAP) service within the Wellington Region, and review outcomes over the last 15 years.

Methods: A retrospective audit of the Paediatric Sleep Service records including clinic letters and polysomnography (PSG) studies for all paediatric patients commenced on CPAP treatment, or for whom CPAP treatment was offered, from November 2005 to December 2020. Data were collected on demographics, medical diagnoses, indications for respiratory support, ENT involvement and surgery. Read More

J Cardiol 2022 Jun 17. Epub 2022 Jun 17.

Department of Multidisciplinary Internal Medicine, Division of Cardiovascular Medicine and Endocrinology and Metabolism, Faculty of Medicine, Tottori University, Yonago, Japan.

Background: Patients with heart failure (HF) often complain of sleep discomfort. Previous reports described that difficulty initiating sleep increased the cardiovascular risk in the general population. However, the association between difficulty initiating sleep and cardiac function in patients with HF remains unclear. Read More

Sleep Med 2022 Jun 9;97:64-72. Epub 2022 Jun 9.

2nd Department of Respiratory Medicine, Institute of Tuberculosis and Lung Diseases, Warsaw, Poland.

Objective: In 2010, a questionnaire-based study on obstructive sleep apnea (OSA) management in Europe identified differences regarding reimbursement, sleep specialist qualification, and titration procedures. Now, 10 years later, a follow-up study was conducted as part of the ESADA (European Sleep Apnea Database) network to explore the development of OSA management over time.

Methods: The 2010 questionnaire including questions on sleep diagnostic, reimbursement, treatment, and certification was updated with questions on telemedicine and distributed to European Sleep Centers to reflect European OSA management practice. Read More

Eur Arch Otorhinolaryngol 2022 Jun 20. Epub 2022 Jun 20.

The Head and Neck Cancer Research Center, Tel Aviv University, Tel Aviv, Israel.

Purpose: Various thyroid pathologies are speculated to contribute to obstructive sleep apnea (OSA). The underlying mechanisms of the intricate relationship between OSA and thyroid structure and function, and whether thyroidectomy can alleviate OSA symptoms remain unclear. An assessment of the impact of thyroidectomy on OSA is warranted. Read More

Can J Neurol Sci 2022 Jun 20:1-23. Epub 2022 Jun 20.

ANZ J Surg 2022 Jun 20. Epub 2022 Jun 20.

Department of Otolaryngology, Head & Neck Surgery, Monash Health, Melbourne, Victoria, Australia.

Background: Severe obstructive sleep apnoea (OSA) is associated with increased risk of respiratory compromise in the post-operative period following adenotonsillectomy (AT). This study analyses the economic cost of polysomnography or overnight oximetry as part of pre-operative risk stratification in paediatric AT, supplementing previously published research demonstrating the efficacy of this protocol in predicting respiratory complications.

Methods: This cost-minimisation analysis examines costs associated with pre-operative overnight oximetry and polysomnography in triaging paediatric patients older than 2 years old, with no major comorbidities except for OSA, undergoing AT for OSA (n = 1801) to either a secondary or quaternary Australian hospital. Read More

Mult Scler Relat Disord 2022 Jun 6;64:103936. Epub 2022 Jun 6.

Multiple Sclerosis Center, Neurocenter of the Southern Switzerland, Regional Hospital (EOC) of Lugano, Lugano 6900, Switzerland; Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano 6900, Switzerland. Electronic address:

Background: Multiple sclerosis (MS) patients with cognitive impairment (CI) frequently suffer from sleep disturbances and emotional symptoms. The aim of this study was to investigate the relationship between CI and sleep disturbances and the role of anxiety and depression on this relationship in MS patients.

Methods: Prospective cross-sectional study including 80 MS patients that underwent neurologic, cognitive, psychiatric assessment, and polysomnographic registration. Read More

Sleep Med 2022 May 31;97:47-54. Epub 2022 May 31.

Department of Respiratory and Critical Care Medicine, Peking University People's Hospital, China. Electronic address:

Objective: To investigate the prevalence of core attention-deficit/hyperactivity disorder (ADHD) symptoms in Chinese narcolepsy type 1 (NT1) patients and to explore mood, quality of life, and executive function in narcolepsy patients with or without ADHD and the response to Methylphenidate Hydrochloride Extended-release tablets (ER-MPH) treatment.

Method: A total of 267 pediatric NT1 patients (194 males and 73 females, 5-17 years old) were evaluated for ADHD symptoms by a psychiatrist using the DSM-IV diagnostic criteria of the Mini International Neuropsychiatric Interview for Children and Adolescents (MINI Kid) from February 2011 to July 2013 at Peking University People's Hospital. All patients underwent Stanford Sleep Inventory (SSI) evaluation and polysomnography followed by multiple sleep latency tests (MSLT) before ER-MPH treatment. Read More

Lung 2022 Jun 18. Epub 2022 Jun 18.

Instituto de Doenças Do Tórax (IDT), Universidade Federal Do Rio de Janeiro (UFRJ), Rua Professor Rodolpho Paulo Rocco, 255 - 1° andar - sala 01D 58/60, Rio de Janeiro, RJ, CEP, 21941-913, Brazil.

Purpose: To evaluate the frequency of sleep-disordered breathing (SDB) and predictors of the presence of nocturnal desaturation in adults with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension.

Methods: Outpatients with a hemodynamic diagnosis of precapillary pulmonary hypertension who underwent portable polysomnography were evaluated. Diagnosis and severity of SDB were assessed using three well-established respiratory disturbance index (RDI) thresholds: 5. Read More

Sleep Breath 2022 Jun 18. Epub 2022 Jun 18.

Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Rationale: Despite increased recognition of sleep disordered breathing in hospitalized patients, studies are lacking on the impact of inpatient adherence with positive airway pressure (PAP) therapy on post-discharge adherence.

Objectives: To assess the predictive value of inpatient adherence to PAP therapy on post-discharge compliance and adherence.

Methods: We reviewed data on individuals as part of a registry of a hospital-based sleep medicine program between August 2019 and December 2020. Read More