J Rheumatol 2017 Sep 1. Epub 2017 Sep 1.
From the Department of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, Alabama; Department of Internal Medicine, and Section of Pulmonary and Critical Care Medicine, and Section of Rheumatology, University of Chicago, Chicago, Illinois, USA. Dr. Dua serves on the advisory board for Genentech and Janssen. Dr. Strek has served as the PI for her institution for studies of therapy for idiopathic pulmonary fibrosis with Gilead, InterMune, and MedImmune. She has served as a member of the Data Safety Committee for Boehringer- Ingelheim. Dr. Vij has received grant funding from Genentech for the study of interstitial lung diseases. N. Sharma, MD, Assistant Professor of Medicine, Department of Clinical Immunology and Rheumatology, University of Alabama at Birmingham; M.S. Putman, MD, Internal Medicine Resident, Department of Internal Medicine, University of Chicago; R. Vij, MD, Clinical Associate of Medicine, Section of Pulmonary and Critical Care Medicine, University of Chicago; M.E. Strek, MD, Professor of Medicine, Section of Pulmonary and Critical Care Medicine, University of Chicago; A. Dua, MD, MPH, Assistant Professor of Medicine, Rheumatology Fellowship Program Director, Section of Rheumatology, University of Chicago. Address correspondence to Dr. N. Sharma, Department of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, 1201 11th Ave. S, Suite 510, Birmingham, Alabama 35205-3410, USA. E-mail: Accepted for publication June 15, 2017.
Objective: Patients with myositis-associated interstitial lung disease (MA-ILD) are often refractory to conventional treatment, and predicting their response to therapy is challenging. Recent case reports and small series suggest that tacrolimus may be useful in refractory cases.
Methods: A retrospective cohort study of patients with MA-ILD comparing clinical characteristics between those who responded to or failed conventional treatment.
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