12,342 results match your criteria Polymyositis


Insights into pathogenesis and clinical implications in myositis-associated interstitial lung diseases.

Curr Opin Pulm Med 2020 Jul 9. Epub 2020 Jul 9.

Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, Osaka, Japan.

Purpose Of Review: Interstitial lung diseases (ILDs) have been reported to be associated with myositis (including polymyositis and dermatomyositis). These myositis-associated ILDs carry significant morbidity and mortality. This review summarizes recent findings on myositis-associated ILD with a focus on pathogenesis and emerging treatment. Read More

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http://dx.doi.org/10.1097/MCP.0000000000000698DOI Listing

The quest for diagnostic approaches of cardiac involvement in polymyositis and dermatomyositis.

Ann Palliat Med 2020 Jul 10. Epub 2020 Jul 10.

Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Polymyositis (PM) and dermatomyositis (DM) are autoimmune diseases characterized by inflammation of skeletal muscle, primarily manifesting as chronic muscle weakness. Extramuscular organs can also be affected. Cardiac involvement is one of the visceral organ damages whose prevalence is underestimated and is a marker of poor prognosis leading to irreversible dysfunction or even death. Read More

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http://dx.doi.org/10.21037/apm-19-650DOI Listing

Mixed Connective Tissue Disease With Retroperitoneal Fibrosis: A Rare Occurrence.

Arch Rheumatol 2020 Mar 6;35(1):137-141. Epub 2019 Nov 6.

Department of Rheumatology, Kalinga Institute of Medical Sciences, Bhubaneswar, India.

Mixed connective tissue disease (MCTD) is an autoimmune condition characterized by mixed clinical features of connective tissue diseases like systemic lupus erythematosus, polymyositis or systemic sclerosis with high titers of anti-U1 small nuclear ribonucleoprotein. Interstitial lung disease is a frequent manifestation of MCTD. Retroperitoneal fibrosis (RPF) is a rare fibro-inflammatory process involving the retroperitoneum. Read More

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http://dx.doi.org/10.5606/ArchRheumatol.2020.7452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322295PMC

Rapid transition from oral selexipag to parenteral treprostinil in a patient with mixed-etiology pulmonary hypertension.

Am J Health Syst Pharm 2020 Jul 4. Epub 2020 Jul 4.

Arizona Pulmonary Specialists, Phoenix, AZ.

Purpose: Selexipag is an oral nonprostanoid IP prostacyclin receptor agonist that is indicated for treatment of pulmonary arterial hypertension (PAH). In patients with continued symptoms of PAH despite maximized oral therapy with selexipag and other oral therapies, a transition to parenteral prostacyclin may be warranted. There is a paucity of data regarding how to safely transition from oral selexipag to parenteral treprostinil. Read More

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http://dx.doi.org/10.1093/ajhp/zxaa158DOI Listing

Multiple acyl-CoA dehydrogenase deficiency (MADD) presenting as polymyositis.

Rheumatology (Oxford) 2020 Jul 2. Epub 2020 Jul 2.

Rheumatology Department, Royal Adelaide Hospital.

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http://dx.doi.org/10.1093/rheumatology/keaa348DOI Listing

[Idiopathic Inflammatory Myopathies].

Dtsch Med Wochenschr 2020 Jul 2;145(13):903-910. Epub 2020 Jul 2.

Myositis is a rare and an extremely heterogeneous autoimmune disease, that causes muscle weakness. Currently, "idiopathic inflammatory myopathies (IIM)" is the preferred umbrella-term used to describe the disease complexity within individuals. IIM include dermatomyositis, polymyositis, inclusion body myositis, autoimmune necrotizing myopathy, overlap myositis and antisynthetase syndrome. Read More

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http://dx.doi.org/10.1055/a-1018-3008DOI Listing

Trends in idiopathic inflammatory myopathies: cross-sectional data from the German National Database.

Rheumatol Int 2020 Jun 27. Epub 2020 Jun 27.

German Rheumatism Research Centre, Epidemiology Unit, Charitéplatz 1, 10117, Berlin, Germany.

Objective: To describe trends in outcomes among patients with idiopathic inflammatory myopathies (IIM) over two decades.

Methods: From 1997 to 2017, a total of 1079 IIM patients were documented in the National Database of the German Collaborative Arthritis Centers. Annual cross-sectional data on treatment, disease activity, patient-reported outcomes, hospitalization and employment were compared across the years. Read More

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http://dx.doi.org/10.1007/s00296-020-04634-0DOI Listing

Similar risk of cardiovascular events in idiopathic inflammatory myopathy and rheumatoid arthritis in the first 5 years after diagnosis.

Clin Rheumatol 2020 Jun 22. Epub 2020 Jun 22.

Centre for Rheumatic Diseases, King's College London, London, UK.

Objectives: To estimate the incidence of cardiovascular (CV) events in idiopathic inflammatory myopathy (IIM) compared to patients with rheumatoid arthritis (RA) and the general population. To explore the contribution of traditional CV risk factors to any difference observed.

Methods: A retrospective matched population-based cohort study was conducted using UK Clinical Practice Research Datalink (CPRD) from 1987 to 2013. Read More

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http://dx.doi.org/10.1007/s10067-020-05237-7DOI Listing

Machine learning algorithms reveal unique gene expression profiles in muscle biopsies from patients with different types of myositis.

Ann Rheum Dis 2020 Jun 16. Epub 2020 Jun 16.

Muscle Disease Unit, Laboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Insititutes of Health, Bethesda, Maryland, USA

Objectives: Myositis is a heterogeneous family of diseases that includes dermatomyositis (DM), antisynthetase syndrome (AS), immune-mediated necrotising myopathy (IMNM), inclusion body myositis (IBM), polymyositis and overlap myositis. Additional subtypes of myositis can be defined by the presence of myositis-specific autoantibodies (MSAs). The purpose of this study was to define unique gene expression profiles in muscle biopsies from patients with MSA-positive DM, AS and IMNM as well as IBM. Read More

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http://dx.doi.org/10.1136/annrheumdis-2019-216599DOI Listing

Renal disorders in rheumatologic diseases: the spectrum is changing (Part 1: connective tissue diseases).

J Nephrol 2020 Jun 11. Epub 2020 Jun 11.

Division of Nephrology, Fondazione Ca' Granda IRCCS Ospedale Maggiore Policlinico Milano, Milano, Italy.

The kidney is frequently involved by autoimmune rheumatic diseases. The renal manifestations may be variable, ranging from asymptomatic proteinuria and microscopic haematuria to nephrotic syndrome and rapidly progressive glomerulonephritis or vasculitis. In a number of cases the kidney involvement is related to the treatment of the original disease and may represent a major cause of morbidity and mortality. Read More

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http://dx.doi.org/10.1007/s40620-020-00772-7DOI Listing

MicroRNA and mRNA profiling in the idiopathic inflammatory myopathies.

BMC Rheumatol 2020 10;4:25. Epub 2020 Jun 10.

Centre for Epidemiology, Division of Population Health, Health Services Research & Primary Care, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.

Background: The idiopathic inflammatory myopathies (IIMs) are heterogeneous autoimmune conditions of skeletal muscle inflammation and weakness. MicroRNAs (miRNAs) are short, non-coding RNA which regulate gene expression of target mRNAs. The aim of this study was to profile miRNA and mRNA in IIM and identify miRNA-mRNA relationships which may be relevant to disease. Read More

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http://dx.doi.org/10.1186/s41927-020-00125-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285612PMC

Evaluation of usefulness in surfactant protein D as a predictor of mortality in myositis-associated interstitial lung disease.

PLoS One 2020 11;15(6):e0234523. Epub 2020 Jun 11.

Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan.

Objective: Surfactant protein D (SP-D) is considered a serum biomarker of various forms of interstitial lung disease (ILD). In this study, we examined the utility of SP-D as a predictive biomarker for mortality in patients with ILD associated with polymyositis/dermatomyositis (PM/DM) using large-scale multicentre cohort data.

Methods: We enrolled 381 patients with incident PM/DM-associated ILD in a multicentre retrospective cohort based on the availability of serum SP-D at the baseline. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234523PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289364PMC

Anti-Ku antibody-positive systemic sclerosis-polymyositis overlap syndrome in an adolescent.

Pediatr Dermatol 2020 Jun 10. Epub 2020 Jun 10.

Departments of Dermatology (Pediatric Dermatology) and Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

Systemic sclerosis-polymyositis overlap syndrome is rare in children. Anti-PM/Scl is the most common autoantibody associated with this syndrome. We present a case of systemic sclerosis-polymyositis overlap syndrome in a child with isolated anti-Ku antibodies, an uncommon antibody associated with this rare syndrome. Read More

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http://dx.doi.org/10.1111/pde.14243DOI Listing

Seasonal and residential clustering at disease onset of anti-MDA5-associated interstitial lung disease.

RMD Open 2020 06;6(2)

Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan

Objectives: To investigate whether the onset of polymyositis (PM)/dermatomyositis (DM)-associated interstitial lung disease (ILD) is influenced by season and residence in the context of myositis-specific autoantibodies.

Methods: For patients with PM/DM-associated ILD enrolled in a multicentre cohort, 365 and 481 patients were eligible for seasonal and geographical analysis, respectively, based on the availability of reliable clinical information. The patients were divided into three groups: (1) anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive patients, (2) anti-aminoacyl tRNA synthetase (anti-ARS) antibody-positive patients and (3) patients negative for those antibodies. Read More

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http://dx.doi.org/10.1136/rmdopen-2020-001202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299503PMC

Intravenous Immunoglobulin for Inflammatory Myositis: Experience in a Tertiary Medical Center.

J Clin Rheumatol 2020 Jun 4. Epub 2020 Jun 4.

From the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv.

Introduction: Inflammatory myopathies are treated with glucocorticoids and other immunosuppressive medications. Intravenous immunoglobulin (IVIG) is increasingly used for refractory or severe cases; however, the evidence for their effectiveness is limited. We assessed effectiveness and safety of IVIG when used with other immunomodulatory agents in the treatment of inflammatory myopathies. Read More

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http://dx.doi.org/10.1097/RHU.0000000000001418DOI Listing

Young-onset Amyotrophic Lateral Sclerosis with Rare Skin Manifestation: Case Report and Literature Review.

Cureus 2020 Apr 27;12(4):e7844. Epub 2020 Apr 27.

Medicine, Dow University of Health Sciences, Karachi, PAK.

Amyotrophic lateral sclerosis (ALS) is one of the most common motor neuron diseases (MND), which presents as muscle weakness, atrophy, spasticity, and, in extreme cases, may result in death due to respiratory failure. ALS has been reported with dermatological conditions such as bullous pemphigoid and decreased collagen. Hyperpigmentation usually occurs due to underlying adrenal or metabolic disorder, but no case of hyperpigmentation has been associated with MND. Read More

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http://dx.doi.org/10.7759/cureus.7844DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253073PMC

Giant Cell Hepatitis - A Rare Association with Connective Tissue Disease.

Mediterr J Rheumatol 2019 Dec 31;30(4):224-227. Epub 2020 Mar 31.

Rheumatology Department, Luton & Dunstable University Hospital, Luton, United Kingdom.

A 68-year-old gentleman presented to hepatology department with asymptomatic year-long history of stably deranged liver function tests. His peak alkaline phosphatase (ALP), was 828 with alanine transaminase (ALT) of 141. Full liver workup was negative; hence, a liver biopsy was organised, which confirmed giant cell hepatitis (GCH). Read More

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http://dx.doi.org/10.31138/mjr.30.4.224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241662PMC
December 2019

Good response to mycophenolate mofetil on treatment of interstitial lung disease in polymyositis associated with antisynthetase syndrome positive for anti-EJ and anti-Ro52 antibodies.

Clin Rheumatol 2020 May 26. Epub 2020 May 26.

Instituto de Investigación en Reumatología y Del Sistema Músculo Esquelético, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada No. 950, Colonia Independencia, 44340, Guadalajara, Jalisco, México.

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http://dx.doi.org/10.1007/s10067-020-05075-7DOI Listing

Epigenetic Methods and Twin Studies.

Adv Exp Med Biol 2020 ;1253:95-104

Humanitas Clinical and Research Center-IRCCS, via Manzoni 56, 20089, Rozzano, Milan, Italy.

Genomic predisposition fails to fully explain the onset of complex diseases, which is well illustrated by the largely incomplete concordance among monozygotic twins. Epigenetic mechanisms, including DNA methylation, chromatin remodeling, and non-coding RNA, are the link between environmental stimuli and disease onset on a permissive genetic background in autoimmune and chronic inflammatory diseases. Autoimmune diseases now include almost 100 conditions and are estimated to cumulatively affect up to 5% of the world population with a healthcare expenditure superior to cancer worldwide. Read More

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http://dx.doi.org/10.1007/978-981-15-3449-2_3DOI Listing

Polymyositis Presenting as Rhabdomyolysis After the Initiation of Omeprazole.

Cureus 2020 May 14;12(5):e8125. Epub 2020 May 14.

Nephrology, Chicago Medical School - Rosalind Franklin University of Medicine and Science, North Chicago, USA.

Rhabdomyolysis is a clinical syndrome with a wide range of presentations; it results in muscle necrosis and release of intracellular muscle contents into the circulation. Inflammatory myopathies are a rare cause of rhabdomyolysis. We present a case of a 46-year-old male with a two-week history of progressively worsening diffuse muscle pain after he had been prescribed omeprazole one month prior. Read More

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http://dx.doi.org/10.7759/cureus.8125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7234030PMC

Mitochondrial Dysfunction: A Common Hallmark Underlying Comorbidity between sIBM and Other Degenerative and Age-Related Diseases.

J Clin Med 2020 May 13;9(5). Epub 2020 May 13.

Muscle Research and Mitochondrial Function Laboratory, CELLEX-IDIBAPS, Faculty of Medicine, University of Barcelona, 08036 Barcelona, Spain.

Sporadic inclusion body myositis (sIBM) is an inflammatory myopathy associated, among others, with mitochondrial dysfunction. Similar molecular features are found in Alzheimer's disease (AD) and Type 2 Diabetes Mellitus (T2DM), underlying potential comorbidity. This study aims to evaluate common clinical and molecular hallmarks among sIBM, AD, and T2DM. Read More

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http://dx.doi.org/10.3390/jcm9051446DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290779PMC

Clinical and Immunological Profile of Mixed Connective Tissue Disease and a Comparison of Four Diagnostic Criteria.

Int J Rheumatol 2020 29;2020:9692030. Epub 2020 Jan 29.

Department of Medicine, Christian Medical College, Vellore 632004, India.

Mixed connective tissue disease (MCTD) was initially described as a chronic immune-mediated disease with overlapping features of systemic lupus erythematosus, scleroderma, and polymyositis. We conducted a cross-sectional study to describe the clinical and immunological profile of patients with MCTD and to compare the four diagnostic criteria, namely, Sharp, Kasukawa, Alarcón-Segovia, and Khan criteria. A total of 291 patients who were admitted from June 2007 to June 2017 and fulfilled the inclusion criteria were included in the study. Read More

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http://dx.doi.org/10.1155/2020/9692030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204172PMC
January 2020

Combined ultrasound-CT approach to monitor acute exacerbation of interstitial lung disease.

Ultrasound J 2020 May 15;12(1):27. Epub 2020 May 15.

Anaesthesia and Intensive Care, San Matteo Hospital, Viale Golgi 19, Pavia, Italy.

Background: Lung ultrasound is a bedside non-irradiating tool for assessment and monitoring of lung diseases. A lung ultrasound score based on visualized artefacts allows reliable quantification of lung aeration, and is useful to monitor mechanical ventilation setting, fluid resuscitation and antibiotic response in critical care. In the context of interstitial lung diseases associated to connective tissue disorders, lung ultrasound has been integrated to computed tomography for diagnosis and follow-up monitoring of chronic lung disease progression. Read More

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http://dx.doi.org/10.1186/s13089-020-00174-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224726PMC

Rationale for and clinical development of anti-fractalkine antibody in rheumatic diseases.

Expert Opin Biol Ther 2020 May 13:1-11. Epub 2020 May 13.

Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan.

: Rheumatic diseases are inflammatory diseases that damage target organs via multiple subsets of immune cells. Fractalkine (FKN) acts as chemoattractant as well as adhesion molecule. It contributes to the pathogenesis of rheumatoid arthritis (RA) and other rheumatic diseases through multiple mechanisms: the migration of monocytes and cytotoxic effector T cells, the proliferation and activation of fibroblast-like synoviocytes, angiogenesis, and osteoclastogenesis. Read More

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http://dx.doi.org/10.1080/14712598.2020.1764931DOI Listing

External validation of EULAR/ACR classification criteria for idiopathic inflammatory myopathies.

Ann Rheum Dis 2020 May 12. Epub 2020 May 12.

Department of Rheumatology, John Hunter Hospital, New Lambton Heights, New South Wales, Australia.

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http://dx.doi.org/10.1136/annrheumdis-2020-217568DOI Listing

Etiologies and outcomes of rheumatology patients with acute respiratory failure requiring intensive care: a single-center medical records review study of 259 patients.

Clin Rheumatol 2020 May 6. Epub 2020 May 6.

Department of Medical ICU, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.

Objective: The etiologies of acute respiratory failure in patients with systemic rheumatic diseases (SRDs) requiring intensive care remain unknown. This study was undertaken to investigate the etiologies and outcomes.

Methods: A medical records review study was performed of 259 adult SRDs patients with respiratory failure admitted to medical ICU across a 5-year period. Read More

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http://dx.doi.org/10.1007/s10067-020-05080-wDOI Listing
May 2020
1.774 Impact Factor

An exploratory study of contractile force production in muscle fibers from patients with inflammatory myopathies.

Muscle Nerve 2020 May 5. Epub 2020 May 5.

Division of Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Newlands, South Africa.

Introduction: The mechanism by which weakness develops in idiopathic inflammatory myopathies (IIMs) is still unclear. In this study we investigated the maximum force of single muscle fibers from patients with IIMs.

Methods: Permeabilized single muscle fibers from patients with IIMs and healthy controls were subjected to contractility measurements. Read More

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http://dx.doi.org/10.1002/mus.26904DOI Listing

Ocular manifestations in rheumatoid arthritis, connective tissue disease and vasculitis: a systematic review and meta-analysis.

J Rheumatol 2020 May 1. Epub 2020 May 1.

From the Schulich School of Medicine, University of Western Ontario, St. Joseph's Health Care, London, Ontario, Canada; University of Toronto, Toronto, Ontario, Canada; Canadian Rheumatology Association Research studentship, University of Western Ontario. This funding was supported through the Canadian Rheumatology Association Roche summer studentship. There are no conflicts of interest. IRB was not necessary as this was a systematic literature review. Address correspondence to Dr. Janet Pope MD MPH FRCPC, Division of Rheumatology, St. Joseph's Health Care, 268 Grosvenor St. London ON N6A 4V2,

Objective: Rheumatoid Arthritis and other rheumatic diseases may present with ocular manifestations. The purpose of our work was to determine the prevalence and type of eye involvement in rheumatoid arthritis and other connective tissue diseases through a meta-analysis and literature review.

Methods: A systematic review of the literature was performed using Medline, Web of Science, and the Cochrane library from their inceptions until January 7, 2019. Read More

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http://dx.doi.org/10.3899/jrheum.190768DOI Listing

Immune Checkpoint Inhibitor-Related Myositis: From Biology to Bedside.

Int J Mol Sci 2020 Apr 26;21(9). Epub 2020 Apr 26.

Department of Biomedical Sciences and Human Oncology, Unit of Internal Medicine "Guido Baccelli", University of Bari Medical School, 70124 Bari, Italy.

Immune checkpoint inhibitor (ICI)-related inflammatory diseases, including polymyositis (PM) and dermatomyositis (DM), in patients suffering from neoplastic disorders represent a medical challenge. The treatment of these conditions has taken on new urgency due to the successful and broad development of cancer-directed immunological-based therapeutic strategies. While primary and secondary PM/DM phenotypes have been pathophysiologically characterized, a rational, stepwise approach to the treatment of patients with ICI-related disease is lacking. Read More

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http://dx.doi.org/10.3390/ijms21093054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246673PMC

Anti-Ku Antibody-Related Scleroderma-Polymyositis Overlap Syndrome Associated With Hypothyroid Myopathy.

J Clin Rheumatol 2020 Apr 25. Epub 2020 Apr 25.

Laboratory of Anatomy, Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.

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http://dx.doi.org/10.1097/RHU.0000000000001395DOI Listing

Nailfold Videocapillaroscopy is a Useful Tool to Recognize Definite Forms of Systemic Sclerosis and Idiopathic Inflammatory Myositis in Interstitial Lung Disease Patients.

Diagnostics (Basel) 2020 Apr 25;10(5). Epub 2020 Apr 25.

Regional Referral Centre for Rare Lung Diseases, A. O. U. "Policlinico-Vittorio Emanuele" Dept. Of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.

Nailfold videocapillaroscopy (NVC) is an easy tool used for the assessment of patients with Raynaud's phenomenon (RP) as possibly associated with systemic sclerosis (SSc). Recent insights have also highlighted its role in the diagnostic assessment of idiopathic inflammatory myopathies (IIMs). The aim of this study is to describe the diagnostic role of NVC in a series of 361 consecutive patients with interstitial lung disease (ILD). Read More

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http://dx.doi.org/10.3390/diagnostics10050253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277171PMC

Myositis as a manifestation of SARS-CoV-2.

Ann Rheum Dis 2020 Apr 23. Epub 2020 Apr 23.

Department of Rheumatology, Bicetre Hospital, Le Kremlin-Bicêtre, France

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http://dx.doi.org/10.1136/annrheumdis-2020-217573DOI Listing

The clinical phenotype associated with antisynthetase autoantibodies.

Reumatologia 2020 28;58(1):4-8. Epub 2020 Feb 28.

Department of Internal Medicine, Connective Tissue Diseases and Geriatrics, Medical University of Gdansk, Gdansk, Poland.

Objectives: Specific systemic autoimmune syndrome characterized by inflammatory myopathy, arthritis or arthralgias, interstitial lung disease (ILD), fever, Raynaud's phenomenon, and mechanic's hands is called antisynthetase syndrome (AS). The aim of this study was to assess the clinical spectrum associated with presence of aminoacyl-transfer RNA synthetase autoantibodies (ASA).

Material And Methods: A total of 305 patients with presence of myositis-specific autoantibodies were identified in the database of immunological tests performed in the Clinical Immunology and Transplantology Unit, Medical University of Gdansk between January 2011 and March 2016. Read More

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http://dx.doi.org/10.5114/reum.2020.93505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174798PMC
February 2020

Development and Study of Semi-Solid Preparations Containing the Model Substance Corticotropin (ACTH): Convenience Application in Neurodegenerative Diseases.

Molecules 2020 Apr 16;25(8). Epub 2020 Apr 16.

"Biochefa" Pharmaceutical Research and Production Plant, 41-200 Sosnowiec, Poland.

Corticotropin (ACTH, previously an adrenocorticotropic hormone) is used in the diagnosis and treatment of pituitary gland disorders, adrenal cortex disorders, and other diseases, including autoimmune polymyositis, systemic lupus erythematosus, rheumatoid arthritis, Crohn's disease, and ulcerative colitis. So far, the ointment dosage form containing ACTH for use on the skin is unknown. Therefore, it seems appropriate to develop a semi-solid formulation with corticotropin. Read More

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http://dx.doi.org/10.3390/molecules25081824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222002PMC

Polymyositis/dermatomyositis is a potential risk factor for acute respiratory failure: a pulmonary heart disease.

Ann Transl Med 2020 Mar;8(5):202

Graduate Institute of Biomedical Sciences and School of Medicine, College of Medicine, China Medical University, Taichung.

Background: Studies on the association between polymyositis/dermatomyositis (PM/DM) and acute respiratory failure (ARF) are considerably limited. We investigated whether ARF is associated with PM/DM using a nationwide cohort study.

Methods: We identified 1,374 patients with newly diagnosed PM/DM and 13,740 comparison individuals without PM/DM (non-PM/DM) randomly selected from the general population; frequency matched by age, sex, and index year using the National Health Insurance Research Database; and followed up until the end of 2011 to measure the incidence of ARF. Read More

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http://dx.doi.org/10.21037/atm.2020.01.56DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154474PMC

Acute concomitant presentation of polymyositis and atypical myasthenia gravis: a diagnostic challenge.

Eur J Neurol 2020 Apr 16. Epub 2020 Apr 16.

Neurology Department, Ramón y Cajal University Hospital, Madrid, Spain.

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http://dx.doi.org/10.1111/ene.14263DOI Listing

Functional Index-3: A Valid and Reliable Functional Outcome Assessment Measure in Dermatomyositis and Polymyositis Patients.

J Rheumatol 2020 Apr 15. Epub 2020 Apr 15.

From the Division of Rheumatology, Department of Medicine, Mayo Clinic in Rochester, MN; Arthritis Associates and Osteoporosis Center of Colorado Springs, Colorado Springs, Colorado 80920; Department of Health Science Research, Division of Biostatistics, Mayo Clinic in Rochester, Minnesota; University of California at Los Angeles, Los Angeles CA; Division of Rheumatology, Department of Medicine, Beacon Hospital, Sandyford, Dublin 18, Ireland; Department of Neurobiology, Care Science and Society, Division of Physiotherapy, and Department of Medicine, Division of Rheumatology Karolinska Institutet, and Function Area Occupational Therapy and Physical Therapy, Karolinska University Hospital, Solna, Stockholm, Sweden. Address correspondence to Floranne Ernste, MD 200 First Street SW Rochester, MN 55905.Email:

Objective: Patients with dermatomyositis (DM) and polymyositis (PM) have reduced muscle endurance. The aim of this study was to streamline the Functional Index-2 (FI-2) by developing the Functional Index-3 (FI-3) and to evaluate its measurement properties, content and construct validity, intra- and inter-rater reliability.

Methods: A data set of the previously performed and validated FI-2 (n=63) was analyzed for internal redundancy, floor and ceiling effects. Read More

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http://dx.doi.org/10.3899/jrheum.191374DOI Listing

Incidence, survival, and risk of cardiovascular events in adult inflammatory myopathies in South Korea: a nationwide population-based study.

Scand J Rheumatol 2020 Apr 14:1-9. Epub 2020 Apr 14.

Department of Preventive Medicine, College of Medicine, Korea University, Seoul, Republic of Korea.

: Epidemiological studies on inflammatory myopathies (IMs) show widely variable results, and studies on Asians are lacking. Despite emerging interest in the cardiovascular disease (CVD) risk associated with IMs, the prevalence of CVD in IM patients and its impact on mortality remain unclear. We conducted a nationwide, population-based study on the incidence, mortality, and associated major CVD events of IMs in the Republic of Korea over 11 years. Read More

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http://dx.doi.org/10.1080/03009742.2019.1707281DOI Listing

A case report of fulminant cytokine release syndrome complicated by dermatomyositis after the combination therapy with immune checkpoint inhibitors.

Medicine (Baltimore) 2020 Apr;99(15):e19741

Department of Neurology, Kobe City Medical Center General Hospital, 650-0047, 2-1-1 Minatojima-Minamimachi, Chuou-ku, Kobe, Hyogo.

Introduction: Immune-related adverse events (ir-AEs) are increasingly becoming a concern, as immune checkpoint inhibitors (ICIs) are used more frequently. Herein, we present a case of fulminant cytokine release syndrome (CRS) complicated by dermatomyositis after the combination therapy with ICIs.

Patient Concerns: A 70-year-old male developed dermatomyositis during the course of treatment with two ICIs, nivolumab and ipilimumab. Read More

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http://dx.doi.org/10.1097/MD.0000000000019741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220092PMC

High pre-treatment neutrophil-to-lymphocyte ratio in patients with dermatomyositis/polymyositis predicts an increased risk of cancer.

Eur J Dermatol 2020 Apr 10. Epub 2020 Apr 10.

Department of Dermatology, University Hospital, Tours, UMR Inserm U1253, University of Tours, Tours, France.

Background: Neutrophil-to-lymphocyte ratio (NLR) is increased and associated with overall survival (OS) in inflammatory diseases including dermatomyositis/polymyositis (DM/PM) and many cancers. The risk of cancer is increased with DM/PM especially in adults > 50 years old.

Objectives: To determine whether high NLR is associated with an increased risk of cancer and OS in DM/PM patients. Read More

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http://dx.doi.org/10.1684/ejd.2020.3756DOI Listing
April 2020
1.990 Impact Factor

Inflammatory myositis in systemic lupus erythematosus.

Lupus 2020 Jun 11;29(7):776-781. Epub 2020 Apr 11.

Division of Rheumatic Diseases, University of Texas Southwestern Medical Center, Dallas, USA.

Background: The coexistence of inflammatory myositis in systemic lupus erythematosus (SLE) has not been extensively studied. In this study, we describe the incidence, distinct types of inflammatory myositis, and risk factors for this finding in a cohort of pediatric and adult SLE patients.

Methods: We identified SLE patients with coexisting myositis followed between 2010 and 2019 at two pediatric hospitals and one adult hospital. Read More

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http://dx.doi.org/10.1177/0961203320918021DOI Listing

Autoimmune pulmonary alveolar proteinosis developed during immunosuppressive treatment in polymyositis with interstitial lung disease: a case report.

BMC Pulm Med 2020 Apr 6;20(1):84. Epub 2020 Apr 6.

Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Minami-Uonuma, Japan.

Background: Pulmonary alveolar proteinosis (PAP) is characterized by the accumulation of surfactant proteins within the alveolar spaces. Autoimmune PAP (APAP) caused by elevated levels of GM-CSF autoantibodies (GM-Ab) is very rarely associated with systemic autoimmune disease. Here we report a case of APAP manifested during immunosuppressive treatment for polymyositis with interstitial lung disease. Read More

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http://dx.doi.org/10.1186/s12890-020-1110-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132862PMC

Juvenile Dermatomyositis and the Inflammatory Myopathies.

Semin Neurol 2020 Jun 6;40(3):342-348. Epub 2020 Apr 6.

Department of Neurology, Dell Medical School, University of Texas, Austin, Texas.

The inflammatory myopathies comprise disorders of immune-mediated muscle injury. The histopathology and clinical features help distinguish them. Juvenile dermatomyositis (JDM) is the most common form of myositis in children and adolescents. Read More

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http://dx.doi.org/10.1055/s-0040-1705120DOI Listing

A patient with anti-NXP2-positive dermatomyositis and syphilis.

Dermatol Online J 2020 Feb 15;26(2). Epub 2020 Feb 15.

Department of Dermatology, University of California Davis, Sacramento, CA.

Dermatomyositis is an auto-immune inflammatory myopathy that primarily affects the skin and muscle and can be triggered by exposure to various environmental factors. We present a patient with active syphilis infection who developed dermatomyositis and discuss the significance of anti-NXP2 autoantibody positivity. Read More

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February 2020

Ultrasound can differentiate inclusion body myositis from disease mimics.

Muscle Nerve 2020 Jun 11;61(6):783-788. Epub 2020 Apr 11.

School of Medicine, Division of Rheumatology, Johns Hopkins University, Baltimore, Maryland.

Introduction: The diagnosis of inclusion body myositis (IBM) can be challenging, and its presentation can be confused with other forms of myositis or neuromuscular disorders. In this study we evaluate the ability of quantitative muscle ultrasound to differentiate between IBM and mimicking diseases.

Methods: Patients 50 years of age and older were included from two specialty centers. Read More

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http://dx.doi.org/10.1002/mus.26875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317807PMC

[A case of juvenile dermatomyositis with neuromyelitis optica spectrum disorders].

Zhonghua Er Ke Za Zhi 2020 Apr;58(4):329-330

Department of Neurology, Anhui Provincial Children's Hospital, Hefei 230051,China.

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http://dx.doi.org/10.3760/cma.j.cn112140-20191128-00757DOI Listing

Analysis of myositis autoantibodies in Chinese patients with cancer-associated myositis.

J Clin Lab Anal 2020 Mar 27:e23307. Epub 2020 Mar 27.

Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.

Background: Cancer-associated myositis (CAM) has poor prognosis and causes higher mortality. In general, myositis-specific autoantibodies (MSAs) and myositis-associated autoantibodies (MAAs) have been shown to be useful biomarkers for its diagnosis.

Methods: In the present study, focus was given in assessing the presence, prevalence, and diagnostic values of myositis autoantibodies in Chinese patients diagnosed with CAM. Read More

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http://dx.doi.org/10.1002/jcla.23307DOI Listing
March 2020
1.144 Impact Factor

Response to: 'Immune-mediated necrotizing myopathies and interstitial lung disease are predominant characteristics in anti-Ku positive patients with idiopathic inflammatory myopathies' by Yang .

Ann Rheum Dis 2020 Mar 25. Epub 2020 Mar 25.

Exploration fonctionnelle musculaire, Service de physiologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.

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http://dx.doi.org/10.1136/annrheumdis-2020-217106DOI Listing

A Study On The Correlation Between Slit2/Robo1 Signaling Pathway Proteins And Polymyositis/Dermatomyositis.

Curr Mol Med 2020 Mar 25. Epub 2020 Mar 25.

Department of Rheumatism and Immunology, Affiliated Hospital of Qinghai University, Xining 810001. China.

Aims: To investigate the role of Slit2 and Robo1 during the vascular disease of Polymyositis (PM) / dermatomyositis (DM).

Background: PM and DM are non-suppurative inflammatory myopathies that mainly invade the skeletal muscles.

Objective: This study attempted to explore the specific mechanism of Slit2/Robo1 signaling pathway proteins during the vascular disease of PM/DM. Read More

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http://dx.doi.org/10.2174/1566524020666200326102837DOI Listing