11,796 results match your criteria Polymyositis


MRI of skeletal muscles in patients with idiopathic inflammatory myopathies: characteristic findings and diagnostic performance in dermatomyositis.

RMD Open 2019 28;5(1):e000850. Epub 2019 Mar 28.

Division of Rheumatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.

Objective: To define the characteristic findings on MRI of skeletal muscles in patients with dermatomyositis (DM) relative to those in patients with other idiopathic inflammatory myopathies (IIMs) and to assess their diagnostic performance in DM.

Methods: Thirty-six patients with DM, 17 patients with amyopathic DM, 19 patients with polymyositis and 16 patients with non-IIM classified by the 2017 European League Against Rheumatism/American College of Rheumatology criteria were included in this study. The following MRI findings (short-tau inversion recovery [STIR] and gadolinium-enhanced fat-suppressed T1-weighted imaging [Gd-T1WI]) for proximal limb muscles were compared between the disease groups and between myositis-specific autoantibodies/myositis-associated autoantibodies (MSAs/MAAs)-positive and MSAs/MAAs-negative groups: structures with high signal intensity (HSI) (subcutaneous, fascia, muscle); distributions of HSI areas in muscle (diffuse, patchy, peripheral) and patterns of HSI in muscle (honeycomb, foggy, strong HSI). Read More

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http://dx.doi.org/10.1136/rmdopen-2018-000850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443133PMC
March 2019
1 Read

[Advances in epigenetic markers of dermatomyositis/polymyositis].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):374-377

Department of Rheumatology and Clinical Immunology, Xiangya Hospital, Central South University, Changsha 410008, China.

Idiopathic inflammatory myopathy (IIM) is a rare group of autoimmune diseases, characterized by chronic muscle weakness, muscle fatigue and infiltration of single nuclear cells in skeletal muscle. Its subtypes include dermatomyositis (DM), polymyositis (PM), inclusion body myositis (IBM) and immune-mediated necrotizing myositis (IMNM), and the most common subtypes are DM and PM. PM is an autoimmune disease mainly manifested by muscle damage. Read More

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April 2019
5 Reads

Response to: 'Idiopathic inflammatory myopathies and antisynthetase syndrome: contribution of antisynthetase antibodies to improve current classification criteria' by Greco .

Ann Rheum Dis 2019 Apr 17. Epub 2019 Apr 17.

Department of Internal Medicine 3, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.

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http://dx.doi.org/10.1136/annrheumdis-2019-215484DOI Listing
April 2019
4 Reads

Frequency, mutual exclusivity and clinical associations of myositis autoantibodies in a combined European cohort of idiopathic inflammatory myopathy patients.

J Autoimmun 2019 Apr 13. Epub 2019 Apr 13.

Department of Pharmacy and Pharmacology, University of Bath, Bath, UK. Electronic address:

Objectives: To determine prevalence and co-existence of myositis specific autoantibodies (MSAs) and myositis associated autoantibodies (MAAs) and associated clinical characteristics in a large cohort of idiopathic inflammatory myopathy (IIM) patients.

Methods: Adult patients with confirmed IIM recruited to the EuroMyositis registry (n = 1637) from four centres were investigated for the presence of MSAs/MAAs by radiolabelled-immunoprecipitation, with confirmation of anti-MDA5 and anti-NXP2 by ELISA. Clinical associations for each autoantibody were calculated for 1483 patients with a single or no known autoantibody by global linear regression modelling. Read More

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http://dx.doi.org/10.1016/j.jaut.2019.04.001DOI Listing
April 2019
1 Read

RNA-sequencing reveals altered skeletal muscle contraction, E3 ligases, autophagy, apoptosis, and chaperone expression in patients with critical illness myopathy.

Skelet Muscle 2019 04 16;9(1). Epub 2019 Apr 16.

Department of Physiology and Pharmacology, Karolinska Institutet, Bioclinicum, J8:30, SE-171 77, Stockholm, Sweden.

Background: Critical illness myopathy (CIM) is associated with severe skeletal muscle wasting and impaired function in intensive care unit (ICU) patients. The mechanisms underlying CIM remain incompletely understood. To elucidate the biological activities occurring at the transcriptional level in the skeletal muscle of ICU patients with CIM, the gene expression profiles, potential upstream regulators, and enrichment pathways were characterized using RNA sequencing (RNA-seq). Read More

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https://skeletalmusclejournal.biomedcentral.com/articles/10.
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http://dx.doi.org/10.1186/s13395-019-0194-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466682PMC
April 2019
3 Reads

Recurring Posterior reversible encephalopathy syndrome in a patient with polymyositis/systemic sclerosis overlap syndrome triggered by scleroderma renal crisis.

Eur J Rheumatol 2019 Apr 9. Epub 2019 Apr 9.

Department of General Internal Medicine, Akashi Medical Center, Akashi, Japan.

In posterior reversible encephalopathy syndrome (PRES) triggered by scleroderma renal crisis (SRC), modulation and adherence in immunosuppressive therapy are key for avoiding recurrence, complications, and death. A patient with polymyositis (PM)/systemic sclerosis (SSc) overlap syndrome developed PRES triggered by SRC. To our knowledge, this is the first report of a case with PRES associated with PM/SSc overlap syndrome. Read More

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http://dx.doi.org/10.5152/eurjrheum.2019.18137DOI Listing
April 2019
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Polymyositis-Dermatomyositis and Interstitial Lung Disease in Pregnant Woman Successfully Treated with Cyclosporine and Tapered Steroid Therapy.

Case Rep Rheumatol 2019 11;2019:4914631. Epub 2019 Mar 11.

Department of Rheumatology, Showa University School of Medicine, Tokyo, Japan.

Polymyositis-dermatomyositis is extremely rare during pregnancy, and immunosuppressive therapy should be administered after carefully considering the effects on both the mother and fetus. Several reports have associated the disease activity with fetal prognosis, higher rates of eclampsia, preterm births, and fetal deaths. We report our experience with a patient who was diagnosed with polymyositis-dermatomyositis complicated by interstitial lung disease during pregnancy and was treated with a combination-immunosuppressant regimen. Read More

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http://dx.doi.org/10.1155/2019/4914631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432726PMC
March 2019
1 Read

Polyphasic Rhabdomyositis in California Sea Lions ( Zalophus Californianus): Pathology and Potential Causes.

Vet Pathol 2019 Apr 14:300985819829526. Epub 2019 Apr 14.

3 The Marine Mammal Center, Sausalito, CA, USA.

A myositis syndrome has been recognized for more than a decade in California sea lions (CSLs; Zalophus californianus) but a detailed description of the lesions and potential causes of this condition is lacking. The tissues of 136 stranded CSLs with rhabdomyositis were examined. Rhabdomyositis was considered incidental in 67% (91/136) of the CSLs, and a factor contributing to the animal stranding (significant rhabdomyositis) in 33% (45/136). Read More

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http://journals.sagepub.com/doi/10.1177/0300985819829526
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http://dx.doi.org/10.1177/0300985819829526DOI Listing
April 2019
3 Reads

Take two: Utility of the repeat skeletal muscle biopsy.

Muscle Nerve 2019 Apr 10. Epub 2019 Apr 10.

Department of Neurology, University of Colorado School of Medicine, Denver, Colorado, USA.

Introduction: The utility of repeat muscle biopsy has not been adequately evaluated.

Methods: A retrospective review was undertaken of 144 repeat muscle biopsies performed from 1980 to 2017. Repeat biopsy was considered clinically relevant if it provided a new diagnosis, changed the existing diagnosis, or led to treatment changes or further investigations. Read More

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http://dx.doi.org/10.1002/mus.26484DOI Listing
April 2019
1 Read

Overlap myositis, a distinct entity beyond primary inflammatory myositis: A retrospective analysis of a large cohort from the REMICAM registry.

Int J Rheum Dis 2019 Apr 10. Epub 2019 Apr 10.

Servicio de Reumatología, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

Background: Inflammatory idiopathic myositis (IIM) comprises a heterogeneous group of systemic muscular diseases that can occur together with other connective tissue diseases (CTD), named overlap myositis (OM). The question of whether OM is a distinct entity still remains controversial.

Aim: The present study was conducted to assess the clinical and prognostic differences between patients diagnosed with OM, primary polymyositis (PM) and primary dermatomyositis (DM). Read More

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http://dx.doi.org/10.1111/1756-185X.13559DOI Listing
April 2019
1 Read

Multi-organ failure induced by Nivolumab in the context of allo-stem cell transplantation.

Exp Hematol Oncol 2019 28;8. Epub 2019 Mar 28.

1Institute for Advanced Biosciences, Université Grenoble Alpes, INSERM 1209, UMR CNRS 5309, Grenoble, France.

Background: Immune checkpoint inhibitors have radically changed the landscape of anti-tumor therapies in several malignancies. However the adverse events associated with immune checkpoint blockade in combination with other treatments remains to be thoroughly documented. Here we report the case of a 33-year-old male with classical Hodgkin lymphoma who was successfully treated for lymphoma but experienced serious and eventually fatal multisystem organ failure following nivolumab administration and allogeneic stem cell transplantation. Read More

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http://dx.doi.org/10.1186/s40164-019-0132-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437980PMC
March 2019
1 Read

A 53-Year-Old Man Presenting With Diplopia and Cavitary Lung Nodules.

Chest 2019 Apr;155(4):e107-e112

Department of Respiratory and Critical Care Medicine, Singapore General Hospital, Singapore.

Case Presentation: A 53-year-old Chinese man presented with 1 week of worsening diplopia and left-sided facial droop. His symptoms developed during a readmission for elective drainage and curettage of a perianal abscess that recurred despite drainage 2 weeks before. He denied having other neurologic symptoms, and did not report any cough, sputum production, night sweats, or fever. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00123692183260
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http://dx.doi.org/10.1016/j.chest.2018.10.021DOI Listing
April 2019
4 Reads
7.483 Impact Factor

Novel susceptibility alleles in HLA region for myositis and myositis specific autoantibodies in Korean patients.

Semin Arthritis Rheum 2019 Mar 9. Epub 2019 Mar 9.

Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, 28 Yongun-dong, Chongno-gu, Seoul 110-744, South Korea; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, College of Medicine, Seoul National University, Seoul, South Korea. Electronic address:

Objectives: HLA genes are a major genetic risk factor for myositis and myositis specific antibodies (MSAs), exhibiting unique HLA backgrounds for myositis in different ethnic groups. This is the first large scale Korean study to genotype the HLA-DRB1 and -DPB1 alleles and to examine their association with myositis and MSAs.

Methods: HLA-DRB1 and HLA-DPB1 alleles and MSAs were examined in 179 patients with dermatomyositis (DM, n = 129) or polymyositis (PM, n = 50) and healthy controls (n = 800 for HLA-DRB1, n = 548 for HLA-DPB1). Read More

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http://dx.doi.org/10.1016/j.semarthrit.2019.03.005DOI Listing
March 2019
4 Reads

Clinical significance of myositis-specific autoantibodies.

Authors:
Ran Nakashima

Immunol Med 2018 Sep 17;41(3):103-112. Epub 2018 Nov 17.

a Department of Rheumatology and Clinical Immunology , Graduate School of Medicine, Kyoto University , Kyoto , Japan.

To date, increasing numbers of myositis-specific autoantibodies (MSAs) have been reported and their clinical significance has been elucidated. Anti-aminoacyl-tRNA synthetase (ARS) and anti-melanoma-differentiation associated gene 5 (MDA5) are strongly associated with interstitial lung disease (ILD); however, the clinical course of ILD is different depending on which autoantibody is present. Anti-ARS is associated with chronic and repetitive ILD and anti-MDA5 is associated with rapidly progressive ILD. Read More

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http://dx.doi.org/10.1080/25785826.2018.1531188DOI Listing
September 2018
3 Reads

Myositis an evolving spectrum of disease.

Immunol Med 2018 Jun 11;41(2):46-54. Epub 2018 Sep 11.

b Division of rheumatology, Department of Medicine , Solna, Karolinska Institutet, and Karolinska University Hospital , Stockholm , Sweden.

The idiopathic inflammatory myopathies (IIMs) are a heterogeneous group of disorders characterized, as common feature, by inflammation of skeletal muscle and muscle weakness. Traditionally, IIMs have been subclassified in into polymyositis, dermatomyositis and inclusion body myositis, but this subclassification has several limitations, because clinical features as well as treatment response vary within the three IIM subgroups. In the last years several novel autoantibodies in patients with IIMs have been identified. Read More

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http://dx.doi.org/10.1080/13497413.2018.1481571DOI Listing
June 2018
6 Reads

Prognostic factors of interstitial lung disease progression at sequential HRCT in anti-synthetase syndrome.

Eur Radiol 2019 Mar 27. Epub 2019 Mar 27.

Department of Pulmonology, China-Japan Friendship Hospital, Beijing, 100029, China.

Objectives: Interstitial lung disease (ILD) is a common extra-muscular manifestation of anti-synthetase syndrome (ASS) and the main cause of morbidity and mortality in patients with ASS. Data on prognostic factors in these patients are lacking.

Methods: A total of 69 patients with ILD and positivity for at least one of the following autoantibodies were included: anti-Jo-1, anti-PL7, anti-PL12, and anti-EJ. Read More

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http://dx.doi.org/10.1007/s00330-019-06152-5DOI Listing
March 2019
1 Read

Global analysis of protein expression in muscle tissues of dermatomyositis/polymyosisits patients demonstrated an association between dysferlin and human leucocyte antigen A.

Rheumatology (Oxford) 2019 Mar 25. Epub 2019 Mar 25.

Department of Rheumatology and Immunology, Xiangya Hospital, Central South University, Changsha, China.

Objectives: DM and PM are characterized by myofibre damage with inflammatory cell infiltration due to the strong expressions of MHC class I HLA-A and monocyte chemoattractant protein-1 (MCP-1). Dysferlin (DYSF) is a transmembrane glycoprotein that anchors in the sarcolemma of myofibres. DYSF mutation is closely associated with inherited myopathies. Read More

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http://dx.doi.org/10.1093/rheumatology/kez085DOI Listing
March 2019
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Comparison of the 2017 EULAR/ACR criteria with Bohan and Peter criteria for the classification of idiopathic inflammatory myopathies.

Clin Rheumatol 2019 Mar 22. Epub 2019 Mar 22.

Department of Clinical Immunology and Rheumatology, St John's Medical College, Sarjapur Road, Bengaluru, 560034, India.

Bohan and Peter is the oldest criteria for the classification of idiopathic inflammatory myopathies (IIM). Recently, 2017 EULAR/ACR criteria were introduced which were validated against a control group. The objective of this study was to assess the performance of the 2017 EULAR/ACR criteria in retrospective cohort of adult and juvenile idiopathic inflammatory myopathies and compare with Bohan and Peter criteria. Read More

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http://dx.doi.org/10.1007/s10067-019-04512-6DOI Listing
March 2019
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Increased risk of coronary heart disease among patients with idiopathic inflammatory myositis: a nationwide population study in Taiwan.

Rheumatology (Oxford) 2019 Mar 21. Epub 2019 Mar 21.

School of Pharmacy, Institute of Clinical Pharmacy and Pharmaceutical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Objective: To evaluate the risk of incident coronary heart disease (CHD) among patients with DM and PM in a general population context.

Methods: We conducted a retrospective cohort study using the Taiwan National Health Insurance Research Database containing records covering the years from 2000 to 2010. DM and PM were confined for the purposes of this study to those aged ⩾18 years who were eligible for the Taiwan catastrophic illness certificate. Read More

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http://dx.doi.org/10.1093/rheumatology/kez076DOI Listing
March 2019
6 Reads

Serum KL-6 is associated with the severity of interstitial lung disease in Chinese patients with polymyositis and dermatomyositis.

Clin Rheumatol 2019 Mar 19. Epub 2019 Mar 19.

Department of Rheumatology, Peking Union Medical College Hospital, Peking Union Medical College &Chinese Academy of Medical Sciences, No.1 Shuaifuyuan, Beijing, 100730, China.

Objective: This cross-sectional study was designed to assess the clinical significance of the serum KL-6 in the diagnosis of interstitial lung disease (ILD) in patients with idiopathic inflammatory myopathy (IIM).

Methods: We measured serum KL-6 levels in 184 patients with IIM using a chemiluminescent enzyme immunoassay and compared KL-6 levels between patients with and without ILD, according to other clinical features.

Results: IIM patients with ILD had significantly higher serum KL-6 levels than those without ILD (776. Read More

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http://dx.doi.org/10.1007/s10067-019-04501-9DOI Listing
March 2019
4 Reads
1.774 Impact Factor

Imaging findings of mixed connective tissue disease in children and adolescents: a case series.

Jpn J Radiol 2019 Mar 14. Epub 2019 Mar 14.

Department of Rheumatology, The Hospital for Sick Children, Department of Medical Imaging, University of Toronto, Toronto, ON, Canada.

Mixed connective tissue disease (MCTD) is a rare disease in children and adolescents which overlaps features of juvenile idiopathic arthritis, polymyositis/dermatomyositis, systemic lupus erythematosus, and systemic sclerosis. We have provided an image-based approach for evaluation of MCTD in children and adolescents, outlying the most frequent imaging findings. This approach would aid imagers and clinicians to consider the diagnosis of this rare entity and be able to make an accurate list of differential diagnosis for complex rheumatologic diseases such as MCTD, thus facilitating the ultimate goal of early diagnosis and optimal management of affected children. Read More

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http://dx.doi.org/10.1007/s11604-019-00824-4DOI Listing
March 2019
1 Read

Is it required to routinely check fibrinogen level in patients with rheumatic diseases on tocilizumab? Case-based review.

Rheumatol Int 2019 Apr 14;39(4):743-750. Epub 2019 Mar 14.

Division of Rheumatology, Department of Internal Medicine, Eskişehir Osmangazi University, Eskisehir, Turkey.

Tocilizumab (TCZ) may rarely cause hematological side effects including neutropenia and thrombocytopenia. TCZ is essentially expected to lower the fibrinogen levels to stay within the normal range, but TCZ-induced hypofibrinogenemia has been rarely reported in literature. Although it may remain asymptomatic, hypofibrinogenemia has clinical significance owing to the tendency of the condition to result in bleeding. Read More

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http://link.springer.com/10.1007/s00296-019-04268-x
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http://dx.doi.org/10.1007/s00296-019-04268-xDOI Listing
April 2019
3 Reads

Variant Guillain-Barré syndrome in a patient with Hodgkin lymphoma: AMSAN.

Turk Pediatri Ars 2018 Dec 1;53(4):263-266. Epub 2018 Dec 1.

Pediatric Hematology and Oncology Clinic, Kanuni Sultan Süleyman Training and Research Hospital, İstanbul, Turkey.

Lymphomas are solid tumors characterized by the malignant proliferation of lymphoid cells. Neurologic signs encountered in patients with Hodgkin's lymphoma can be due to the direct spread of tumor to the nervous system, secondary to chemotherapy or radiation, secondary to tumor mass compression, infectious causes and paraneoplastic syndromes. Paraneoplastic neurologic syndromes are rarely encountered in patients with Hodgkin's lymphoma and non-Hodgkin's lymphoma. Read More

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http://dx.doi.org/10.5152/TurkPediatriArs.2018.4763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408190PMC
December 2018
1 Read

The spectrum and clinical significance of myositis-specific autoantibodies in Chinese patients with idiopathic inflammatory myopathies.

Clin Rheumatol 2019 Mar 12. Epub 2019 Mar 12.

Department of Rheumatology, China-Japan Friendship Hospital, No. 2 Yinghua East Street, Chaoyang District, Beijing, China.

Objectives: The aim of this study is to analyze the prevalence of myositis-specific autoantibodies (MSAs) and to elucidate their associations with clinical features in Chinese patients with polymyositis (PM) and dermatomyositis (DM).

Methods: Twelve subsets of MSAs including anti-Mi-2, anti-TIF1-γ, anti-MDA5, anti-NXP2, anti-SAE1, anti-SRP, anti-Jo-1, anti-PL-7, anti-PL-12, anti-EJ, anti-OJ, and anti-HMGCR antibodies were tested. Four hundred and ninety-seven PM/DM patients were enrolled. Read More

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http://dx.doi.org/10.1007/s10067-019-04503-7DOI Listing
March 2019
3 Reads

Spontaneous resolution of dermatomyositis associated with fallopian-tube carcinoma following staging surgery: A case report.

Medicine (Baltimore) 2019 Mar;98(10):e14530

Department of Gynecologic Oncology, West China Second Hospital, Sichuan University.

Rationale: Paraneoplastic dermatomyositis (DM) is an inflammatory disease of the connective tissue caused by immunologic events in the presence of malignant tumors, which are typically related to ovarian, pancreatic, stomach, and colon cancer. Traditional treatment of paraneoplastic DM includes combination therapy for the underlying malignancy with systemic steroids.

Patient Concerns: A 41-year-old woman presented with facial erythema and myalgia of the extremities. Read More

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http://dx.doi.org/10.1097/MD.0000000000014530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417515PMC
March 2019
1 Read

Serum matrix metalloproteinase levels in polymyositis/dermatomyositis patients with interstitial lung disease.

Rheumatology (Oxford) 2019 Mar 8. Epub 2019 Mar 8.

Department of Respiratory Medicine.

Objective: We aimed to clarify the clinical significance of serum levels of MMPs in interstitial lung disease (ILD) complicated with PM/DM (PM/DM-ILD).

Methods: We retrospectively analysed serum levels of seven subsets of MMPs in 52 PM/DM-ILD patients diagnosed at Kyoto University Hospital or Tenri Hospital from January 2005 to December 2014. The patients were sub-grouped based on the presence of anti-amimoacyl-tRNA synthetase antibody (anti-ARS antibody), anti-melanoma differentiation-associated protein 5 antibody (anti-MDA5 antibody) or lack of the antibodies (ARS-ILD, MDA5-ILD and other-ILD groups, respectively) and independently analysed. Read More

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http://dx.doi.org/10.1093/rheumatology/kez065DOI Listing
March 2019
5 Reads

Muscle fluorodeoxyglucose uptake assessed by positron emission tomography-computed tomography as a biomarker of inflammatory myopathies disease activity.

Rheumatology (Oxford) 2019 Mar 8. Epub 2019 Mar 8.

Federation of Translational Medicine of Strasbourg, Strasbourg University, Strasbourg, France.

Objective: To devise a simple PET-CT score for measurement of muscle disease activity in patients with inflammatory myopathies (IMs) and to assess its validity.

Methods: A total of 44 PET-CT examinations in 34 IM patients (performed during cancer screening) and 20 PET-CT examinations in matched controls (investigated for pulmonary nodules with a conclusion of benignity) were analysed. Maximal standardized uptake values (SUVmax) were recorded bilaterally in eight proximal muscles. Read More

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http://dx.doi.org/10.1093/rheumatology/kez040DOI Listing
March 2019
2 Reads

Shared genetic factors and their causality in autoimmune diseases.

Ann Rheum Dis 2019 Mar 6. Epub 2019 Mar 6.

Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.

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http://dx.doi.org/10.1136/annrheumdis-2019-215099DOI Listing
March 2019
1 Read

Clinical characteristics and outcome in patients with antisynthetase syndrome associated interstitial lung disease: a retrospective cohort study.

Eur Clin Respir J 2019 27;6(1):1583516. Epub 2019 Feb 27.

Department of Respiratory Diseases, Sydvestjydsk Regional Hospital, Esbjerg, Denmark.

: To describe the clinical characteristics including the bronchoalveolar lavage fluid (BALF) characteristics of patients with antisynthetase syndrome (AS) associated interstitial lung disease (ILD) in a tertiary ILD outpatient clinic, their medical therapy and outcome. : Retrospective cohort study of patients with AS-ILD. All available data of clinical characteristics, pulmonary function tests, laboratory parameters, BALF analysis, histology, high-resolution computed tomography (HRCT) and treatment were collected from the patient files. Read More

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http://dx.doi.org/10.1080/20018525.2019.1583516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394310PMC
February 2019
4 Reads

Incidence and Prevalence of Idiopathic Inflammatory Myopathies in Korea: a Nationwide Population-based Study.

J Korean Med Sci 2019 Mar 8;34(8):e55. Epub 2019 Feb 8.

Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea.

Background: This study aimed to estimate the incidence and prevalence of idiopathic inflammatory myopathies (IIM) and associated comorbidities in Korea from 2006 to 2015.

Methods: IIM between 2004 to 2015 were identified using the Korean National Health Insurance Service medical claim database. The case definition required more than one visit based on diagnostic codes including juvenile dermatomyositis (JDM), dermatomyositis (DM), or polymyositis (PM) and registration in the Individual Copayment Beneficiaries Program (ICBP) for rare and intractable diseases. Read More

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http://dx.doi.org/10.3346/jkms.2019.34.e55DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393764PMC
March 2019
1 Read

Autoantibody testing in idiopathic inflammatory myopathies.

Pract Neurol 2019 Mar 2. Epub 2019 Mar 2.

Department of Neurology, Center for Neuroscience Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.

The diagnosis and classification of idiopathic inflammatory myopathies are based mainly on clinical and histological features. The discovery of myositis-specific and myositis-associated antibodies has simplified the (sub)classification of inflammatory myopathies. Patients suspected of having an idiopathic inflammatory myopathy should undergo routine antibody testing to gain more insight into distinct phenotypes, comorbidities, treatment response and prognosis. Read More

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http://dx.doi.org/10.1136/practneurol-2017-001742DOI Listing
March 2019
1 Read

Integrated therapy decreases the mortality of patients with polymyositis and dermatomyositis: A Taiwan-wide population-based retrospective study.

J Ethnopharmacol 2019 May 25;236:70-81. Epub 2019 Feb 25.

Department of Neurology, Kuang Tien General Hospital, Taichung, Taiwan; Department of Nutrition, Huang-Kuang University, Taichung, Taiwan. Electronic address:

Ethnopharmacological Relevance: The issue of whether integrated treatment with conventional medicine (CM) and herbal medicine (HM) can reduce mortality in patients with polymyositis/dermatomyositis (PM/DM) had not been addressed.

Aim Of The Study: In this study, we investigated the effect of integrated therapy on mortality in a retrospective PM/DM cohort in the Taiwan National Health Insurance Research Database (NHIRD).

Materials And Methods: Patients with PM/DM were retrospectively enrolled from the PM/DM Registry of Catastrophic Illnesses cohort in the Taiwan NHIRD between 1997 and 2011. Read More

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http://dx.doi.org/10.1016/j.jep.2019.02.042DOI Listing
May 2019
2 Reads
2.998 Impact Factor

Autoimmune Connective Tissue Diseases and the Risk of Rotator Cuff Repair Surgery: A Population-Based Retrospective Cohort Study.

BMJ Open 2019 Feb 25;9(2):e023848. Epub 2019 Feb 25.

Department of Mathematics, Soochow University, Taipei, Taiwan.

Objectives: Autoimmune connective tissue diseases (ACTDs) commonly involve the shoulder joint; however, clinical epidemiological studies investigating their association with tendons are scant. Rotator cuff (RC) tears can cause shoulder disability, and surgical intervention is usually required. The study investigated RC repair surgery risk in ACTD patients. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398915PMC
February 2019
3 Reads

Late Onset Multiple Acyl-CoA Dehydrogenase Deficiency (MADD) Myopathy Misdiagnosed as Polymyositis.

J Clin Rheumatol 2019 Feb 19. Epub 2019 Feb 19.

Neurology Department, Raymond-Poincaré Teaching Hospital, Centre de référence des Maladies Neuromusculaires Nord/Est/Ile-de-France, AP-HP, Garches.

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http://dx.doi.org/10.1097/RHU.0000000000001000DOI Listing
February 2019
2 Reads

Liver dysfunction in anti-melanoma differentiation-associated gene 5 antibody-positive patients with dermatomyositis.

Rheumatol Int 2019 Feb 21. Epub 2019 Feb 21.

Division of Rheumatology and Clinical Immunology, Department of Medicine, Jichi Medical University, Tochigi, Japan.

The objective was to investigate the clinical and histological features of liver dysfunction in patients with polymyositis (PM) or dermatomyositis (DM).A total of 115 patients (38 with PM and 77 with DM), who were admitted to our hospital between 2001 and 2012, were retrospectively reviewed. Liver dysfunction was defined as an alanine transaminase (ALT) level ≥ 60 U/l and a disproportionate ALT elevation relative to the creatine kinase level. Read More

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http://dx.doi.org/10.1007/s00296-019-04255-2DOI Listing
February 2019
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The MIG Chemokine in Inflammatory Myopathies.

Authors:
S R Paparo

Clin Ter 2019 Jan-Feb;170(1):e55-e60

Department of Clinical and Experimental Medicine, University of Pisa, Italy.

The chemokine monokine induced by interferon (IFN)-γ (MIG) is expressed in idiopathic inflammatory myopathies muscle. Abundant expression of MIG was observed on macrophages and T cells surrounding and invading non-necrotic muscle fibers in polymyositis and in inclusion-body myositis and in T cells in perimysial infiltrates of dermatomyositis. MIG is also localized to blood vessel endothelial cells in all inflammatory and normal muscle tissues and it exerts its biological effects mainly via binding to the chemokine (C-X-C motif) receptor (CXCR)3. Read More

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http://dx.doi.org/10.7417/CT.2019.2108DOI Listing

Biomarkers in Adult Dermatomyositis: Tools to Help the Diagnosis and Predict the Clinical Outcome.

J Immunol Res 2019 14;2019:9141420. Epub 2019 Jan 14.

INSERM U976, Laboratory of Oncodermatology, Immunology, and Cutaneous Stem Cells, Hôpital Saint-Louis, Paris, France.

Dermatomyositis pathophysiology is complex. In recent years, medical research has identified molecules associated with disease activity. Besides providing insights into the driving mechanisms of dermatomyositis, these findings could provide potential biomarkers. Read More

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http://dx.doi.org/10.1155/2019/9141420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350546PMC
April 2019
2 Reads

Detection of serum MCP-1 and TGF-β1 in polymyositis/dermatomyositis patients and its significance.

Eur J Med Res 2019 Feb 14;24(1):12. Epub 2019 Feb 14.

Department of Immunology, No. 983 of the Chinese People's Liberation Army Joint Support Force, No. 60 of Huangwei Street, Hebei District, Tianjin, 300142, China.

Objective: This study aims to detect serum levels of monocyte chemoattractant protein-1 (MPC-1) and transforming growth factor-β1 (TGF-β1) in polymyositis/dermatomyositis (PM/DM) patients complicated with interstitial lung disease (ILD), to reveal the significance of the changes in these levels in the pathogenesis of PM/DM complicated with ILD.

Methods: Serum MCP-1 and TGF-β1 levels in PM/DM patients complicated with ILD, patients with pulmonary infections and normal controls (n = 30, each) were detected using enzyme-linked immunosorbent assay (ELISA), and the correlation between PM/DM complicated with ILD and serum MCP-1 and TGF-β1 levels was analyzed.

Results: Serum MCP-1 and TGF-β1 levels were both higher in PM/DM patients complicated with ILD compared with patients with pulmonary infections and normal controls. Read More

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http://dx.doi.org/10.1186/s40001-019-0368-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376678PMC
February 2019
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1.398 Impact Factor

[18F]Florbetapir positron emission tomography: identification of muscle amyloid in inclusion body myositis and differentiation from polymyositis.

Ann Rheum Dis 2019 May 13;78(5):657-662. Epub 2019 Feb 13.

The National Institute for Health Research Manchester Musculoskeletal Biomedical Research Centre, Manchester University Hospitals NHS FoundationTrust, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom.

Objectives: With the tools available currently, confirming the diagnosis of inclusion body myositis (IBM) can be difficult. Many patients are initially misdiagnosed with polymyositis (PM). In this observational study at a UK adult neuromuscular centre, we investigated whether amyloid positron emission tomography could differentiate between IBM and PM. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-214644DOI Listing
May 2019
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Outcomes of Pregnancy in Women With Inflammatory Myositis: A Retrospective Cohort From India.

J Clin Rheumatol 2019 Feb 1. Epub 2019 Feb 1.

From the Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.

Objectives: Idiopathic inflammatory myositis (IIM) commonly affects women in the childbearing age group. Both disease activity and immunosuppressants used may have adverse effects on fertility and outcomes of pregnancy. We explored these outcomes in a retrospective cohort of women with IIM. Read More

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http://dx.doi.org/10.1097/RHU.0000000000000996DOI Listing
February 2019
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Strategy for suspected myositis.

Joint Bone Spine 2019 Feb 1. Epub 2019 Feb 1.

Service de rhumatologie, hôpitaux universitaires de Strasbourg, 67098 Strasbourg, France; Centre de référence des maladies autoimmunes rares de l'Est et Sud Ouest, 33000 Bordeaux, France; Fédération de médecine translationnelle de Strasbourg, université de Strasbourg, 67081 Strasbourg, France.

Skeletal muscle inflammation is the feature shared by all forms of myositis. However, the muscle damage ranges in severity from asymptomatic to responsible for severe weakness. In addition, myositis usually occurs as a systemic disease that affects multiple organs. Read More

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http://dx.doi.org/10.1016/j.jbspin.2019.01.013DOI Listing
February 2019
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Inflammatory myopathy with myasthenia gravis: Thymoma association and polymyositis pathology.

Neurol Neuroimmunol Neuroinflamm 2019 Mar 24;6(2):e535. Epub 2018 Dec 24.

Department of Neurology (N.U., K.T., C.I., A.U., A.K., T.T., J.S.), Graduate School of Medicine, University of Tokyo; Division of Neurology (M.K., K.K.), Department of Internal Medicine, National Defense Medical College, Saitama; Division of Neurology (Y. Shiio), Tokyo Teishin Hospital; Department of Neurology (Y. Sakurai), Mitsui Memorial Hospital; Department of Neurology (Y.H.), Teikyo University School of Medicine; and Department of Neurology (K.Y., S.N.-E.), Fukushima Medical University, Japan.

Objective: To provide evidence that idiopathic inflammatory myopathy (IM) with myasthenia gravis (MG) frequently shows thymoma association and polymyositis (PM) pathology and shares clinicopathologic characteristics with IM induced by immune checkpoint inhibitors (ICIs).

Methods: We analyzed the clinicopathologic features of 10 patients with idiopathic IM and MG identified in 970 consecutive patients with biopsy-proven IM.

Results: Seven patients (70%) had thymoma. Read More

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http://dx.doi.org/10.1212/NXI.0000000000000535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340335PMC
March 2019
12 Reads

Androgen deprivation therapy for prostate cancer and the risk of autoimmune diseases.

Prostate Cancer Prostatic Dis 2019 Jan 28. Epub 2019 Jan 28.

Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan.

Background: Androgen deprivation therapy (ADT) has been a mainstay of treatment for advanced prostate cancer (PCa), but limited studies have been performed to investigate the association between ADT and autoimmune diseases.

Methods: We conducted a population-based nationwide cohort study of 17,168 patients newly diagnosed with PCa between 1996 and 2013 using the National Health Insurance Research Database (NHIRD) of Taiwan. Cox proportional hazards models with 1:1 propensity score-matched analysis were used to investigate the association between ADT use and the risk of autoimmune diseases. Read More

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http://www.nature.com/articles/s41391-019-0130-9
Publisher Site
http://dx.doi.org/10.1038/s41391-019-0130-9DOI Listing
January 2019
19 Reads

[A Case of Cecal Cancer Associated with Dermatomyositis].

Gan To Kagaku Ryoho 2018 Dec;45(13):2196-2198

Dept. of Surgery, Kindai University Faculty of Medicine.

We report a relatively rare case of cecal cancer with dermatomyositis. An 81-year-old man was diagnosed with dermatomyositis associated with the symptoms of eruption, limb muscle weakness, and difficulty swallowing. Colonoscopy revealed a type 2 tumor in the cecum. Read More

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December 2018
2 Reads

Pulmonary hypertension on systemic sclerosis-lupus erythematosus overlap syndrome.

Ann Cardiol Angeiol (Paris) 2019 Jan 23. Epub 2019 Jan 23.

Habib Thameur Hospital, Internal Medicine Department, Tunis, Tunisia; University of Tunis el Manar Faculty of Medicine of Tunis, Tunisia.

Purpose: There are authentic observations of combination of systemic lupus erythematosus (SLE) with systemic sclerosis (SS) and with polymyositis defined as overlap syndromes. The prevalence of pulmonary hypertension is unknown in SS-SLE overlap syndrome because of its rarity. The aim of our study was to precise clinical, paraclinical and evolutive features of pulmonary hypertension in patients with systemic sclerosis-systemic lupus erythematosus (SS-SLE) overlap syndrome. Read More

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http://dx.doi.org/10.1016/j.ancard.2018.10.012DOI Listing
January 2019
3 Reads

Pro-inflammatory S100A11 is elevated in inflammatory myopathies and reflects disease activity and extramuscular manifestations in myositis.

Cytokine 2019 Apr 23;116:13-20. Epub 2019 Jan 23.

Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic. Electronic address:

Background: S100A11 (calgizzarin), a member of the S100 family, is associated with oncogenesis, inflammation and myocardial damage. Our aim was to analyse S100A11 in idiopathic inflammatory myopathies (IIMs) and its association with disease activity features and cancer development.

Methods: S100A11 in muscle was determined by immunohistochemistry in polymyositis (PM), dermatomyositis (DM), myasthenia gravis (MG) and in subjects without autoimmune inflammatory disease (HC). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10434666193001
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http://dx.doi.org/10.1016/j.cyto.2018.12.023DOI Listing
April 2019
7 Reads