3,151 results match your criteria Polymyalgia Rheumatica


Comorbidities in polymyalgia rheumatica: a systematic review.

Arthritis Res Ther 2018 Nov 20;20(1):258. Epub 2018 Nov 20.

Arthritis Research UK Primary Care Centre, Primary Care Sciences, Keele University, Keele, ST5 5BG, UK.

Background And Aim: Comorbidities are known to exist in many rheumatological conditions. Polymyalgia rheumatica (PMR) is a common inflammatory rheumatological condition affecting older people which, prior to effective treatment, causes severe disability. Our understanding of associated comorbidities in PMR is based only on case reports or series and small cohort studies. Read More

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November 2018
3 Reads

Myositis and neuromuscular side-effects induced by immune checkpoint inhibitors.

Eur J Cancer 2018 Nov 16;106:12-23. Epub 2018 Nov 16.

Department of Dermatology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Germany. Electronic address:

Aim: To characterise clinical presentation, laboratory and histopathologic characteristics and assess the treatment and outcome of neuromuscular side-effects of checkpoint therapy.

Methods: The side-effect registry and the institutional database from ten skin cancer centres were queried for reports on myositis and neuromuscular side-effects induced by checkpoint inhibitors. In total, 38 patients treated with ipilimumab, tremelimumab, nivolumab and pembrolizumab for metastatic skin cancer were evaluated and characterised. Read More

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November 2018
7 Reads

Paraneoplastic Syndrome Presenting with Polymyalgia Rheumatica-like Accumulations on F-fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography.

Intern Med 2018 Nov 19. Epub 2018 Nov 19.

Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan.

A 70-year-old woman presented with a fever and pain in both lower extremities and the right shoulder and right upper arm continuously for approximately 3 months. F-fluorodeoxyglucose-positron emission tomography/computed tomography (F-FDG/PET-CT) revealed the accumulation of FDG in the right shoulder, lumbar spinous processes, both ischial tuberosities, and both hips and greater trochanters, indicating polymyalgia rheumatica (PMR). In addition, upper gastrointestinal endoscopy revealed esophageal carcinoma. Read More

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November 2018
5 Reads

Cardiovascular toxicities associated with immune checkpoint inhibitors: an observational, retrospective, pharmacovigilance study.

Lancet Oncol 2018 Dec 12;19(12):1579-1589. Epub 2018 Nov 12.

Cardio-Oncology Program, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address:

Background: Immune checkpoint inhibitors (ICIs) have substantially improved clinical outcomes in multiple cancer types and are increasingly being used in early disease settings and in combinations of different immunotherapies. However, ICIs can also cause severe or fatal immune-related adverse-events (irAEs). We aimed to identify and characterise cardiovascular irAEs that are significantly associated with ICIs. Read More

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December 2018
3 Reads

Rheumatic immune-related adverse events secondary to anti-programmed death-1 antibodies and preliminary analysis on the impact of corticosteroids on anti-tumour response: A case series.

Eur J Cancer 2018 Dec 13;105:88-102. Epub 2018 Nov 13.

Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia; Sir Peter MacCallum Department, University of Melbourne, Melbourne, Australia. Electronic address:

Importance: Rheumatic immune-related adverse events (irAEs) occur in approximately 10-20% of anti-programmed death 1 (anti-PD1)-treated cancer patients. There are limited data on the natural history, optimal treatment and long-term oncological outcomes of patients with rheumatic irAEs.

Objective: The objective of the study was to describe the spectrum and natural history of rheumatic irAEs and the potential impact of rheumatic irAEs and immunomodulators on anti-PD1 tumour efficacy. Read More

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December 2018
10 Reads

Does low risk of infections as a marker of effective immunity predict increased risk of subsequent giant cell arteritis or polymyalgia rheumatica? A Danish population-based case-control study.

Clin Epidemiol 2018 16;10:1533-1543. Epub 2018 Oct 16.

Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark,

Objective: It has been suggested that a hyper-effective immune system ("hyper-immunity") is central to the pathogenesis of giant cell arteritis and polymyalgia rheumatica (GCA/PMR). We examined if a low risk of infections, as a marker of hyper-immunity, can predict increased subsequent risk of GCA/PMR.

Patients And Methods: We conducted a population-based case-control study including all patients aged ≥50 years with incident GCA/PMR diagnosed between 1997 and 2012 in Northern Denmark. Read More

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October 2018
3 Reads

[Glucocorticoid sensitive bilateral leg swelling in an 85-year-old woman presenting with polymyalgia rheumatica: A case report].

Rev Med Interne 2018 Oct 31. Epub 2018 Oct 31.

Service de rhumatologie, centre hospitalier René-Dubos, 6, avenue de l'Île-de-France, 95301 Pontoise, France. Electronic address:

Introduction: Polymyalgia rheumatica (PMR) can be associated with distal swelling indicating an associated RS3PE syndrome. We report a case of PMR associated with oedema of the lower limbs, which resolved rapidly under glucocorticoid therapy.

Case Report: A 85-year-old woman presented with a 4 month history of PMR responding to the 2012 EULAR/ACR classification criteria. Read More

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October 2018
1 Read

Permanent Discontinuation of Glucocorticoids in Polymyalgia Rheumatica is Uncommon but May Be Enhanced by Amino Bisphosphonates.

J Rheumatol 2018 Nov 1. Epub 2018 Nov 1.

From the Rheumatology Unit, Department of Medicine, University of Verona, Verona, Italy. A. Giollo, MD, Rheumatology Unit, Department of Medicine, University of Verona; M. Rossini, MD, PhD, Rheumatology Unit, Department of Medicine, University of Verona; F. Bettili, MD, Rheumatology Unit, Department of Medicine, University of Verona; F. Ghellere, MD, Rheumatology Unit, Department of Medicine, University of Verona; E. Fracassi, MD, PhD, Rheumatology Unit, Department of Medicine, University of Verona; L. Idolazzi, MD, PhD, Rheumatology Unit, Department of Medicine, University of Verona; D. Gatti, MD, PhD, Rheumatology Unit, Department of Medicine, University of Verona; O. Viapiana, MD, PhD, Rheumatology Unit, Department of Medicine, University of Verona. Address correspondence to Dr. A. Giollo, Rheumatology Unit, Department of Medicine, University of Verona, Piazzale L.A. Scuro 10, 37134 Verona, Italy. E-mail: Accepted for publication August 8, 2018.

Objective: The duration of treatment with glucocorticoids (GC) in polymyalgia rheumatica (PMR) is often longterm. Amino bisphosphonates (N-BP) are used in PMR for the prevention of GC-induced osteoporosis, but they could also have immunomodulatory properties. Whether they can be effective as an adjuvant treatment in PMR is unknown. Read More

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November 2018
2 Reads

Incidence of inflammatory polyarthritis in polymyalgia rheumatica: a population-based cohort study.

Ann Rheum Dis 2018 Oct 26. Epub 2018 Oct 26.

Norwich Medical School, Bob Champion Research and Education Building, University of East Anglia, Norwich, UK.

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October 2018
1 Read

Corticosteroid Tapering Regimens in Rheumatic Disease: A Systematic Review.

J Clin Rheumatol 2018 Oct 23. Epub 2018 Oct 23.

Background/objective: Corticosteroids have long been used to effectively treat rheumatic disorders, but adverse effects associated with extended-duration regimens generate disagreement among clinicians regarding optimal tapering strategies. The objective of this systematic review was to assess clinical outcomes of differing tapering regimens after corticosteroid monotherapy in adults with rheumatic disorders.

Methods: A systematic review of Medline/PubMed, Embase, Cochrane, International Pharmaceutical Abstracts, Web of Science, Scopus, Global Index Medicus, American College of Rheumatology, gray literature, and reference lists up to June 27, 2018, was conducted by 2 authors. Read More

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October 2018
7 Reads

Challenges of diagnosing and managing polymyalgia rheumatica: a multi-methods study in UK general practice.

Br J Gen Pract 2018 Nov;68(676):e783-e793

Institute for Primary Care and Health Sciences, NIHR research professor in general practice, NIHR CLAHRC West Midlands, deputy director, NIHR School for Primary Care Research, and training lead, Arthritis Research UK Primary Care Centre, Primary Care Sciences, Keele University, Keele.

Background: Polymyalgia rheumatica (PMR) is one of the most common inflammatory arthritic disorders seen in older individuals. Most patients with PMR are diagnosed and managed exclusively in general practice, yet primary care-focused research is lacking.

Aim: To identify and explore the challenges of diagnosis and management of PMR in general practice. Read More

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November 2018
8 Reads

Swollen joints and peripheral arthritis are signs of malignancy in polymyalgia rheumatica.

Mod Rheumatol 2018 Oct 18:1-11. Epub 2018 Oct 18.

h Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences , Nagasaki University Graduate School of Biomedical Sciences , Nagasaki , Japan.

Aim: To analyze the clinical course and prognosis in patients diagnosed with polymyalgia rheumatica (PMR) complicated by the presence of malignancies.

Methods: We retrospectively screened the case files of 216 patients hospitalized in our department between 2011 and December 2016 for the results of a thorough physical examination and data on treatment for rheumatic diseases. We identified 53 patients with PMR according to Bird's criteria and 43 patients with 2012 European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) classification criteria for PMR, then analyzed the clinical and serologic manifestations of PMR in patients with (n = 6) and without (n = 47 in Bird' criteria, n = 37 in 2012 EULAR/ACR criteria) malignancy. Read More

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October 2018
6 Reads

Applications of PET Imaging in the Evaluation of Musculoskeletal Diseases Among the Geriatric Population.

Semin Nucl Med 2018 Nov 6;48(6):525-534. Epub 2018 Aug 6.

Department of Radiology, Hospital of University of Pennsylvania, Philadelphia, PA. Electronic address:

Medical imaging plays a particularly important role in the care of elderly patients, in whom complex symptomatology and a high prevalence of musculoskeletal diseases necessitate sensitive imaging modalities. MRI is the most commonly used imaging modality in the evaluation of various musculoskeletal disorders. The integration of positron emission technique and computed tomography as well as magnetic resonance imaging allows for generating complimentary data for accurate and quantitative diagnosis. Read More

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November 2018
3 Reads

A Comparative Study of Doppler Ultrasound against Temporary Artery Biopsy in the Diagnosis of Giant Cell Arteritis.

Reumatol Clin 2018 Oct 11. Epub 2018 Oct 11.

Servicio de Reumatología, Complexo Hospitalario Universitario de A Coruña, La Coruña, España.

Background: Giant cell arteritis (GCA) is a vasculitis that affects medium- and large-sized arteries. Temporal artery biopsy is the gold standard for diagnosis. In view of the high demand for temporal biopsies, the purpose of this study is to evaluate the usefulness of Doppler ultrasonography in patients with suspected giant cell arteritis, to determine its sensitivity and specificity as a diagnostic test and to determine whether it would be possible to substitute biopsy for ultrasonography. Read More

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October 2018
1 Read

Towards standardized patient reported physical function outcome reporting: linking ten commonly used questionnaires to a common metric.

Qual Life Res 2018 Oct 13. Epub 2018 Oct 13.

Department of Psychology, Health and Technology, University of Twente, PO BOX 50 000, 7500 KA, Enschede, The Netherlands.

Objectives: Outcomes obtained using different physical function patient reported outcome measures (PROMs) are difficult to compare. To facilitate standardization of physical function outcome measurement and reporting we developed an item response theory (IRT) based standardized physical function score metric for ten commonly used physical function PROMs.

Methods: Data of a total of 16,386 respondents from representative cohorts of patients with rheumatic diseases as well as the Dutch general population were used to map the items of ten commonly used physical function PROMs on a continuous latent physical function variable. Read More

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October 2018
1 Read

Incidence, prevalence and treatment burden of polymyalgia rheumatica in the UK over two decades: a population-based study.

Ann Rheum Dis 2018 Dec 8;77(12):1750-1756. Epub 2018 Oct 8.

Arthritis UK Primary Care Centre, Keele University, Keele, UK.

Objective: Polymyalgia rheumatica (PMR) is the most common inflammatory rheumatic disease in older people. Contemporary estimates of the incidence and prevalence are lacking, and no previous study has assessed treatment patterns at a population level. This study aims to address this. Read More

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December 2018
4 Reads

Use of contrast-enhanced magnetic resonance imaging of the pelvis to describe changes at different anatomic sites which are potentially specific for polymyalgia rheumatica.

Clin Exp Rheumatol 2018 Sep-Oct;36 Suppl 114(5):86-95. Epub 2018 Oct 1.

Rheumazentrum Ruhrgebiet, Herne, Germany.

Objectives: To identify inflammatory pelvic structures of patients with polymyalgia rheumatica (PMR) by magnetic resonance imaging (MRI) in detail, searching for a disease-specific pattern.

Methods: A total of 40 contrast-enhanced pelvic MRIs of patients with a clinical diagnosis of PMR was reviewed by an experienced musculoskeletal radiologist who assessed all abnormalities semi-quantitatively, based on a predefined scoring system.

Results: The median (25th/75th percentiles) age of patients was 67 (55/73) years, median symptom duration 13 (6/22) weeks, 55% female, median CRP 1. Read More

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October 2018
6 Reads

A case of pembrolizumab-induced autoimmune haemolytic anaemia with polymyalgia rheumatica.

Eur J Cancer 2018 Nov 1;103:281-283. Epub 2018 Oct 1.

Department of Internal Medicine, Nîmes University Hospital, Nîmes, France. Electronic address:

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November 2018
3 Reads

Cross-sectional survey of the undergraduate rheumatology curriculum in European medical schools: a EULAR School of Rheumatology initiative.

RMD Open 2018 21;4(2):e000743. Epub 2018 Sep 21.

Université Paris Diderot, USPC, UFR de Médecine, Paris, France.

Objectives: To survey the undergraduate rheumatic and musculoskeletal diseases (RMDs) curriculum content in a sample of medical schools across Europe.

Methods: The undergraduate musculoskeletal diseases and disability curriculum of University of Nottingham, UK, was used as a template to develop a questionnaire on curriculum content. The questionnaire elicited binary (yes/no) responses and included the option to provide additional information as free text. Read More

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September 2018
10 Reads

Common carotid arteritis and polymyalgia with Mycoplasma pneumoniae infection.

J Infect Chemother 2018 Sep 28. Epub 2018 Sep 28.

Department of Pediatrics, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi 783-8505, Japan. Electronic address:

A few pediatric cases with brain vasculitis most frequently affecting the middle cerebral artery have been reported in association with Mycoplasma pneumoniae infection, but involvement of the common carotid artery (CCA) before the bifurcation has not been reported to date. We report herein a case of 10-year-old boy with common carotid arteritis and polymyalgia associated with Mycoplasma pneumoniae infection. His fever and cough began 2 weeks before, and his right upper and lower extremity pains began 2 days before admission. Read More

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September 2018
2 Reads

[Improved early diagnostics of rheumatic diseases : Monocentric experiences with an open rheumatological specialist consultation].

Z Rheumatol 2018 Nov;77(9):844-849

Standort Berlin Buch, Immanuel Krankenhaus Berlin, Lindenberger Weg 19, 13125, Berlin, Deutschland.

Aim Of The Project: To establish an open rheumatological outpatient consultation service for early diagnosis of inflammatory rheumatic diseases and initiation of further diagnostics and treatment.

Methods: In 2015 an open consultation service was initiated for patients with signs of an early rheumatic disease after referral by primary care physicians. Patients could attend once a week without the need for a prior appointment if they fulfilled at least one of the following criteria: positive rheumatoid factor, increased CRP, anti-CCP antibody or antinuclear antibody, joint pain or back pain for over 3 months, swollen joints, fever of unknown origin or acute muscle pain with or without headache of unknown origin. Read More

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November 2018
1 Read

Differences in clinical manifestations and prognosis of Chinese giant cell arteritis patients with or without polymyalgia rheumatica.

Ir J Med Sci 2018 Sep 24. Epub 2018 Sep 24.

Department of General Internal Medicine, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Science (CAMS) and Peking Union Medical College (PUMC), Beijing, 100730, China.

Background: The symptoms of giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) frequently overlap in the elderly. Whether there are differences in clinical features or prognosis between GCA patients with or without PMR remains unknown.

Aims: To identify differences in clinical manifestation and prognosis between Chinese GCA patients with or without PMR. Read More

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September 2018
2 Reads

Polymyalgia rheumatica due to pembrolizumab therapy.

J Oncol Pharm Pract 2018 Sep 24:1078155218800386. Epub 2018 Sep 24.

2 Lucy Curci Cancer Center, Eisenhower Medical Center, Rancho Mirage, CA, USA.

Pembrolizumab is a humanized anti-programmed cell death 1 antibody used for the therapy of several malignancies. While autoimmune adverse events are not uncommon with this agent, they are typically mild and self-limiting. Severe autoimmunity is rare but can be life-threatening. Read More

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September 2018
9 Reads

Polymyalgia Rheumatica (PMR) with Normal Values of Both Erythrocyte Sedimentation Rate (ESR) and C-Reactive Protein (CRP) Concentration at the Time of Diagnosis in a Centenarian Man: A Case Report.

Authors:
Ciro Manzo

Diseases 2018 Sep 20;6(4). Epub 2018 Sep 20.

Internal and Geriatric Medicine Department, Azienda Sanitaria Locale Napoli 3 Sud, Rheumatologic Outpatient Clinic and Ambulatory of Geriatric Rheumatology, "Mariano Lauro" Hospital, 80065 Sant'Agnello, Italy.

The possibility that polymyalgia rheumatica (PMR) can be diagnosed when both ESR and CRP are normal at the time of diagnosis and before therapy with glucocorticoids, has been often discussed in the literature. We present a case report of a 100-year-old Caucasian man referred to our outpatient clinic, complaining of chronic pain in the shoulder and hip girdle associated with normal values of both ESR (21 mm/1st hour) and CRP (4 mg/dL). In the previous four months, several anti-inflammatory drugs and painkillers associated with physiotherapy treatments gave no significant improvement in pain and self-care. Read More

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September 2018
2 Reads

Pancreatic cancer and autoimmune diseases: An association sustained by computational and epidemiological case-control approaches.

Int J Cancer 2018 Sep 19. Epub 2018 Sep 19.

PanGenEU Study Investigators (Additional file 1: Annex S1).

Deciphering the underlying genetic basis behind pancreatic cancer (PC) and its associated multimorbidities will enhance our knowledge toward PC control. The study investigated the common genetic background of PC and different morbidities through a computational approach and further evaluated the less explored association between PC and autoimmune diseases (AIDs) through an epidemiological analysis. Gene-disease associations (GDAs) of 26 morbidities of interest and PC were obtained using the DisGeNET public discovery platform. Read More

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September 2018
2 Reads

Diagnostic FDG PET/CT findings in Polymyalgia Rheumatica.

QJM 2018 Sep 7. Epub 2018 Sep 7.

Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kitaku, Okayama 700-8558, Japan.

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September 2018
3 Reads

The INCLUDE study: INtegrating and improving Care for patients with infLammatory rheUmatological DisordErs in the community; identifying multimorbidity: Protocol for a pilot randomized controlled trial.

J Comorb 2018 2;8(1):2235042X18792373. Epub 2018 Aug 2.

Arthritis Research UK Primary Care Centre, Research Institute for Primary Care and Health Sciences, Keele University, Keele, UK.

Background: Patients with inflammatory rheumatic conditions such as rheumatoid arthritis, polymyalgia rheumatica and ankylosing spondylitis are at increased risk of common comorbidities such as cardiovascular disease, osteoporosis and anxiety and depression which lead to increased morbidity and mortality. These associated morbidities are often un-recognized and under-treated. While patients with other long-term conditions such as diabetes are invited for routine reviews in primary care, which may include identification and management of co-morbidities, at present this does not occur for patients with inflammatory conditions, and thus, opportunities to diagnose and optimally manage these comorbidities are missed. Read More

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August 2018
2 Reads

A case of anti-melanoma differentiation-associated gene 5 antibody-positive interstitial lung disease complicated with tracheobronchial ulcers.

Respir Med Case Rep 2018 24;25:189-191. Epub 2018 Aug 24.

Department of Respiratory Medicine, Saitama Red Cross Hospital, Saitama, Japan.

We herein report the first case, to our knowledge, of tracheobronchial ulcer with anti-melanoma differentiation-associated gene 5 (anti-MDA 5) antibody-positive interstitial lung disease (ILD). A 53-year-old man complained of shoulder and wrist pain and was suspected of having polymyalgia rheumatica at another hospital. Thereafter, treatment with prednisolone was started. Read More

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August 2018
1 Read

Giant cell arteritis as unusual cause of critical arm ischemia.

J Vasc Surg Cases Innov Tech 2018 Sep 30;4(3):248-251. Epub 2018 Aug 30.

Department of Cardiac, Vascular and Thoracic Surgery, Kepler University Hospital, Linz, Austria.

Giant cell arteritis is an inflammatory vasculopathy of unknown etiology that typically affects the carotid artery and its branches. Symptomatic involvement of upper extremity arteries is uncommon. We report a case of a 70-year-old woman with polymyalgia rheumatica who presented with critical arm ischemia, constitutional symptoms, and elevated erythrocyte sedimentation rate. Read More

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September 2018
4 Reads

Characteristics of Korean Patients with Polymyalgia Rheumatica: a Single Locomotive Pain Clinic Cohort Study.

J Korean Med Sci 2018 Sep 10;33(36):e241. Epub 2018 Aug 10.

Department of Physical and Rehabilitation Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background: Polymyalgia rheumatica (PMR) is a common systemic inflammatory disease of the elderly; however, the clinical characteristics and therapeutic response of PMR in Korea have been rarely studied.

Methods: We reviewed the medical records of 54 Korean patients diagnosed with PMR between January 2009 and February 2017 in a locomotive pain clinic of one tertiary referral hospital. We analyzed epidemiologic and clinical characteristics, therapeutic responses, and prognostic factors for remission-failure at one-year after oral prednisolone treatment. Read More

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September 2018
3 Reads

West Nile Neuroinvasive Disease Presenting as Elsberg Syndrome.

Neurologist 2018 Sep;23(5):152-154

Division of Critical Care Neurology.

Introduction: Elsberg syndrome (ES) is a rarely recognized cause of cauda equina syndrome and lower thoracic myelitis, mainly linked to reactivation, or occasionally primary, infection with herpes simplex virus type 2. West Nile virus neuroinvasive disease is rarely considered in the differential diagnosis of patients with ES.

Case Report: A 63-year-old man with pancreatic cancer in remission and polymyalgia rheumatica on low-dose prednisone presented with a 10-day history of low-back pain and a viral-type illness with low-grade fever, nausea, and vomiting. Read More

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September 2018
18 Reads

Application of 2012 EULAR/ACR criteria for polymyalgia rheumatica to Korean patients previously classified by Chuang and Hunder criteria or Healey criteria.

Int J Rheum Dis 2018 Oct 30;21(10):1838-1843. Epub 2018 Aug 30.

Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

Aim: To apply 2012 European League Against Rheumatism/American College of Rheumatology (EULAR/ACR) criteria to Korean patients previously classified as polymyalgia rheumatica (PMR) by Chuang and Hunder criteria or Healey criteria and investigated whether they might be still reclassified as PMR or not.

Methods: We retrospectively reviewed the medical records of 113 previously classified PMR patients. We applied 2012 EULAR/ACR criteria without ultrasonography to PMR patients, and fulfilment required at least 4 points. Read More

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October 2018
1 Read

Characteristics and treatment of new-onset arthritis after checkpoint inhibitor therapy.

RMD Open 2018 17;4(2):e000714. Epub 2018 Aug 17.

Division of Rheumatology and Clinical Immunology, Department of Internal Medicine IV, Ludwig-Maximilians-University Munich, Munich, Germany.

Immune checkpoint inhibitors (ICIs) may cause immune-related adverse events (IRAEs). Characterisation and data on treatment of musculoskeletal IRAEs are scarce. In this cohort study, patients receiving ICI therapy who experienced arthralgia were evaluated for the presence of synovitis. Read More

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August 2018
10 Reads

Additional costs of polymyalgia rheumatica with giant-cell arteritis.

Arthritis Care Res (Hoboken) 2018 Aug 29. Epub 2018 Aug 29.

Unité d'Evaluation Médico-Economique, Département d'Information Médicale, Centre Hospitalier Universitaire, Toulouse, F-31059, France.

Objective: To assess and compare direct costs between patients with giant-cell arteritis (GCA) associated or not with polymyalgia rheumatic (PMR), and to identify the additional cost drivers due to PMR.

Methods: We conducted a population-based, retrospective, cohort study using the French National Health Insurance System Database. Cost analysis was performed from the French health-insurance perspective and took into account direct medical and non-medical costs (€2014). Read More

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August 2018
8 Reads

The availability of health information to patients with newly diagnosed polymyalgia rheumatica: results from the Polymyalgia Rheumatica (PMR) Cohort study.

Prim Health Care Res Dev 2018 Aug 8:1-5. Epub 2018 Aug 8.

6Senior Research Fellow in Epidemiology and Applied Statistics,Research Institute for Primary Care & Health Sciences,Keele University,Keele,UK.

AimThe aim of this study was to assess the provision of information to, and seeking of information by, patients newly diagnosed with polymyalgia rheumatica (PMR) in primary care.

Background: PMR is an inflammatory rheumatological condition of older people that can be treated with long-term oral glucocorticoids. Management usually requires the patient to understand the potential complications of treatment and the disease, as well as involvement in reducing treatment dose. Read More

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August 2018
2 Reads

Support available for and perceived priorities of people with polymyalgia rheumatica and giant cell arteritis: results of the PMRGCAuk members' survey 2017.

Clin Rheumatol 2018 Dec 31;37(12):3411-3418. Epub 2018 Jul 31.

PMRGCAuk, London, UK.

Polymyalgia rheumatica and giant cell arteritis are relatively common, but under research inflammatory rheumatological conditions. This survey aimed to ascertain the matters in which patients feel they need support with these conditions and appraise how the Charity PMRGCAuk currently supports these needs and could do so in the future. PMRGCAuk members (n = 910) were invited to complete an on-line survey. Read More

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December 2018
12 Reads

Temporal Arteritis Presenting as an Isolated Bilateral Abducens Nerve Palsy: A Rare Case of a 65-year-old Male.

Cureus 2018 May 22;10(5):e2667. Epub 2018 May 22.

Department of Neurology, University Of Kentucky College of Medicine.

Giant cell arteritis (GCA) or temporal arteritis (TA) is a granulomatous inflammation of medium to large-sized arteries. It may have a diverse presentation. The most common presenting symptoms of GCA are fever, malaise, unilateral headache, jaw claudication, polymyalgia rheumatica (PMR) and ophthalmoplegia. Read More

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May 2018
6 Reads

A case report of polymyalgia rheumatica.

Reumatologia 2018 30;56(3):190-193. Epub 2018 Jun 30.

Kharkiv National Medical University, Ukraine.

The presented case report concerns a 62-year-old male patient who was admitted to the rheumatology department with a fever, shoulder and hip joint pain, significant limitation of movement in these joints and general weakness. Laboratory test revealed increase of inflammatory parameters, as ESR and C-reactive protein, rheumatoid factor and ACPA antibodies were absent. In the course of diagnostics, infections and cancer were excluded. Read More

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June 2018
2 Reads

Diagnosis of polymyalgia rheumatica in primary health care: favoring and confounding factors - a cohort study.

Reumatologia 2018 30;56(3):131-139. Epub 2018 Jun 30.

Clinical Research, Telemedicine and Telepharmacy Centre, School of Pharmacy, University of Camerino, Camerino, Italy.

Objectives: To evaluate in a primary care setting the favoring and confounding factors for the diagnosis of polymyalgia rheumatica (PMR).

Material And Methods: Among 303 patients consecutively referred by their general practitioners (GPs) to our rheumatologic outpatient clinic, we identified three groups: group A - patients with confirmed diagnosis of PMR, group B - patients with unconfirmed diagnosis, group C - patients with unrecognized PMR. All the diagnostic confounding and favoring factors were discussed with GPs using an e-mail questionnaire. Read More

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June 2018
7 Reads

Drug therapies for polymyalgia rheumatica: a pharmacotherapeutic update.

Expert Opin Pharmacother 2018 Aug 24;19(11):1235-1244. Epub 2018 Jul 24.

d Rheumatology Division , Hospital de La Princesa, IIS-Princesa, Universidad Autónoma de Madrid (UAM) , Madrid , Spain.

Introduction: Polymyalgia rheumatica (PMR), a common disease in individuals older than 50 in the western world, is characterized by bilateral inflammatory pain involving the shoulder girdle and less commonly the neck and pelvic girdle. The main goals of the currently available treatment are to induce remission and prevent relapse. Areas covered: This review briefly presents the main epidemiological and clinical features of PMR and discusses in depth both its classical management as well as new therapies used in PMR. Read More

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August 2018
13 Reads

Fever of unknown origin following parathyroidectomy prior to onset of typical polymyalgia rheumatica symptoms: a case report.

Int J Gen Med 2018 16;11:307-311. Epub 2018 Jul 16.

Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.

Polymyalgia rheumatica (PMR) is a disease commonly seen in elderly individuals, however, the etiology has not been reported. Typical clinical features include bilateral shoulder pain and morning stiffness, while serologic autoantibody test findings are negative. Approximately 40%-50% of affected patients present with low-grade fever, fatigue, and appetite loss, which we often experience in the field of general medicine, and thus, the condition should not be given low priority. Read More

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July 2018
5 Reads

Longitudinal expression profiling of CD4+ and CD8+ cells in patients with active to quiescent giant cell arteritis.

BMC Med Genomics 2018 Jul 23;11(1):61. Epub 2018 Jul 23.

Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072, Queensland, Australia.

Background: Giant cell arteritis (GCA) is the most common form of vasculitis affecting elderly people. It is one of the few true ophthalmic emergencies but symptoms and signs are variable thereby making it a challenging disease to diagnose. A temporal artery biopsy is the gold standard to confirm GCA, but there are currently no specific biochemical markers to aid diagnosis. Read More

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July 2018
8 Reads

[A Case of Essential Thrombocythemia with a JAK2V617F Mutation andPolymyalgia Rheumatica].

Authors:
Kenji Shinohara

Gan To Kagaku Ryoho 2018 Jun;45(6):1001-1003

Dept. of Internal Medicine, Towa Hospital.

A patient with polymyalgia rheumatica(PMR)had increasing thrombocytosis. CRP levels, the ESR, and serum interleukin (IL)-6 levels were slightly elevated, and the patient tested negative for RF and anti CCP antibodies. Muscle pain was ameliorated with the administration of corticosteroids. Read More

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June 2018
11 Reads

Does early seronegative arthritis develop into rheumatoid arthritis? A 10-year observational study.

Clin Exp Rheumatol 2018 Jun 7. Epub 2018 Jun 7.

Department of Rheumatology, Central Hospital of Central Finland, Jyväskylä, Finland.

Objectives: To investigate the 10-year clinical course of patients with seronegative arthritis with the emphasis of reclassification of diagnoses when applicable.

Methods: A total of 1030 patients including 435 seronegative cases were classified as early RA in 1997-2005 at Jyväskylä Rheumatology Centre and prospectively scheduled for a ten-year follow-up. Clinical data from the follow-up visits and the case-reports until and including the 10-year visit or death, whichever happened earlier, were retrospectively collected and reviewed with re-classification of the cases when applicable. Read More

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June 2018
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Retrospective analysis of the usefulness of a protocol with high-dose methotrexate in polymyalgia rheumatica: Results of a single-center cohort of 100 patients.

Geriatr Gerontol Int 2018 Sep 6;18(9):1410-1414. Epub 2018 Jul 6.

Department of Medical Area, Clinic of Rheumatology, University of Udine, Udine, Italy.

Aim: The aim of the present study was to define subsets of patients suffering from polymyalgia rheumatica, where methotrexate (MTX) up to 20 mg/week might be more effective.

Methods: A total of 100 patients with polymyalgia rheumatica treated with MTX were studied. The criteria for MTX introduction were: (i) relapse during the first month of therapy, when tapering glucocorticoids (GC); (ii) requiring long-term GC (i. Read More

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September 2018
3 Reads

The real evidence for polymyalgia rheumatic as a paraneoplastic syndrome.

Reumatismo 2018 Jul 6;70(2):118-119. Epub 2018 Jul 6.

Institute for Primary Care & Health Sciences, Keele University.

Not available. Read More

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July 2018
1 Read

The real evidence for polymyalgia rheumatic as a paraneoplastic syndrome.

Reumatismo 2018 Jul 6;70(2):1148. Epub 2018 Jul 6.

Department of Translational Medicine, Università del Piemonte Orientale UPO, Novara, Italy; Division of Internal Medicine, Sant'Andrea Hospital, Vercelli, Italy; Interdisciplinary Research Center of Autoimmune Diseases (IRCAD), Novara.

Not available. Read More

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July 2018
12 Reads

Polymyalgia rheumatica: an autoinflammatory disorder?

RMD Open 2018 4;4(1):e000694. Epub 2018 Jun 4.

Rheumatology and Rheumatology Unit, University Clinic AOU of Cagliari, Cagliari, Italy.

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June 2018
1 Read

Temporal small arterial inflammation is common in patients with giant cell arteritis.

Hum Pathol 2018 Nov 25;81:65-70. Epub 2018 Jun 25.

Department of Pathology and Laboratory Medicine, Rhode Island Hospital/The Miriam Hospital, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA.

Giant cell arteritis (GCA) primarily involves medium-to-large arteries. Small-vessel inflammation is a recognized phenomenon occurring in association with GCA. However, its significance is poorly elucidated. Read More

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November 2018
2 Reads

The co-existence of Lemierre's syndrome and Bezold's abscesses due to Streptococcus constellatus: A case report.

Medicine (Baltimore) 2018 Jun;97(26):e11228

Department of Infection Control and Prevention, Kurume University School of Medicine.

Rationale: The ancient infectious diseases, Lemierre's Syndrome and Bezold's Abscesses are rare.

Patient Concerns: A 70-year-old Japanese woman with a 15-year history of Parkinson's disease was referred to our hospital due to fever, occipital headache and bilateral shoulder pain that had continued for three months. She had been prescribed prednisolone due to a diagnosis of polymyalgia rheumatica. Read More

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June 2018
17 Reads