296 results match your criteria Polymorphous Light Eruption


The Immunogenetics of Photodermatoses.

Adv Exp Med Biol 2022 ;1367:369-381

Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, Tainan, Taiwan.

Photodermatosis is an abnormal skin inflammatory reaction to light. The major classifications of photodermatoses are idiopathic photodermatoses, photodermatoses due to exogenous or endogenous agents, photo-exacerbated dermatoses, and photosensitive genodermatoses. In this chapter, we focus on idiopathic photodermatoses and drug-related photodermatoses and emphasize on the epidemiology and immunogenetic backgrounds. Read More

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CD123 immunoexpression in cutaneous lupus erythematosus, polymorphous light eruption, pityriasis rosea, and mycosis fungoides.

Postepy Dermatol Alergol 2021 Dec 7;38(6):994-1000. Epub 2022 Jan 7.

Department of Pathology, Duzce University, School of Medicine, Duzce, Turkey.

Introduction: CD123-positive plasmacytoid dendrocytes are prominent in the infiltrate of cutaneous lupus erythematous.

Aim: To determine the significance of the CD123 immunostain, which labels plasmacytoid dendritic cells (PDC), in cutaneous lupus erythematous (CLE), polymorphous light eruption (PLE), pityriasis rosea (PR) and mycosis fungoides (MF).

Material And Methods: A total of 76 cases, including MF ( = 27), CLE ( = 19), PR ( = 19), and PLE ( = 11), were included in the study after reviewing their diagnostic clinical features and pathologic findings. Read More

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December 2021

Drug triggered pruritus, rash, papules, and blisters - is AGEP a clash of an altered sphingolipid-metabolism and lysosomotropism of drugs accumulating in the skin?

Lipids Health Dis 2021 Nov 8;20(1):156. Epub 2021 Nov 8.

Institute of Precision Medicine, Medical and Life Sciences Faculty, Furtwangen University, Jakob-Kienzle-Str. 17, D-78054, Villingen-Schwenningen, Germany.

Rash, photosensitivity, erythema multiforme, and the acute generalized exanthematous pustulosis (AGEP) are relatively uncommon adverse reactions of drugs. To date, the etiology is not well understood and individual susceptibility still remains unknown. Amiodarone, chlorpromazine, amitriptyline, and trimipramine are classified lysosomotropic as well as photosensitizing, however, they fail to trigger rash and pruritic papules in all individuals. Read More

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November 2021

A photodistributed eruption in an immunosuppressed patient.

JAAD Case Rep 2021 Sep 24;15:19-21. Epub 2021 Jun 24.

Department of Dermatology, University of Florida College of Medicine, Gainesville, Florida.

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September 2021

Does smoking affect your skin?

Postepy Dermatol Alergol 2021 Jun 25;38(3):371-376. Epub 2021 Jan 25.

Department of Dermatology, Centre of Postgraduate Medical Education, Central Clinical Hospital of the Ministry of the Interior, Warsaw, Poland.

Smoking has a negative influence on human beings. Carcinogens detected in smoke can increase the risk of developing chronic disorders, cancer and premature death. Nicotine can also affect dermatological diseases such as psoriasis, hidradenitis suppurativa, chronic dermatoses, alopecia, lupus erythematosus, polymorphous light eruption, skin cancer and tobacco-associated oral lesions. Read More

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Contribution of phototesting in the diagnosis of photodermatoses: Retrospective study of 100 cases.

Photodermatol Photoimmunol Photomed 2022 Mar 5;38(2):99-103. Epub 2021 Aug 5.

Dermatology, allergology and photobiology Department, Grenoble-Alpes University Hospital, Grenoble, France.

Background: Photodermatoses are sun-related inflammatory skin diseases. They usually require phototesting in diagnosis. However, fewer and fewer medical centers in France are equipped with photobiological equipment. Read More

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: 21st Century Evidence for an Ancient Medicinal Plant.

J Cutan Med Surg 2021 Nov-Dec;25(6):656-657. Epub 2021 Jun 15.

233826 Department of Dermatology and Skin Science, University of British Columbia, Vancouver, Canada.

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February 2022

Polymorphous Light Eruption- An Indian Scenario.

Indian Dermatol Online J 2021 Mar-Apr;12(2):211-219. Epub 2021 Mar 2.

Department of Dermatology, Venereology and Leprosy, Pondicherry Institute of Medical Sciences, Pondicherry, India.

Polymorphous light eruption (PMLE) is the most common, idiopathic, acquired photodermatosis, characterized by abnormal, recurrent, and delayed reaction to sunlight. Polymorphous light eruption is common worldwide but the morphology, distribution, and pigmentary changes are unique in Indian skin which is discussed in this review. The prevalence of PMLE is around 10-20% in the general population. Read More

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Recurrent erythematous papules on the chest.

JAAD Case Rep 2021 Jan 1;7:17-19. Epub 2020 Nov 1.

Department of Dermatology and Venereology, Soroka University Medical Center, Beer-Sheva, Israel.

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January 2021

Erythroderma: A clinicopathological study of 47 cases from 2018 to 2020.

Dermatol Ther 2020 11 10;33(6):e14342. Epub 2020 Oct 10.

Department of Dermatology and Venereology, Cerrahpaşa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey.

Erythroderma, or exfoliative dermatitis, is an inflammatory disorder characterized by erythema and scaling, affecting most of the skin surface. It may be a result of many different causes such as previous dermatoses (psoriasis, eczema, atopic dermatitis [AD], pityriasis rubra pilaris, and pemphigus foliaceous), drug reactions, malignancies (mycosis fungoides [MF], Sézary syndrome, adult T cell leukemia/lymphoma), infections, and idiopathic disorders. Regardless of the etiology, the clinical appearance of erythroderma is similar in all patients. Read More

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November 2020

Polymorphic light eruption sine eruptione: A variant of polymorphous light eruption.

Photodermatol Photoimmunol Photomed 2020 Sep 11;36(5):396-397. Epub 2020 May 11.

Department of Dermatology, Henry Ford Hospital, Detroit, MI, USA.

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September 2020

Comparison of racial distribution of photodermatoses in USA academic dermatology clinics: A multicenter retrospective analysis of 1080 patients over a 10-year period.

Photodermatol Photoimmunol Photomed 2020 May 12;36(3):233-240. Epub 2020 Mar 12.

Department of Dermatology, Henry Ford Hospital, Detroit, Michigan.

Background: Previous studies at single academic institutions have identified variations in the prevalence of photodermatoses among racial groups. The purpose of the study was to compare the distribution of photodermatoses between Whites and Blacks at four academic medical centers in the USA.

Methods: A retrospective chart review was performed at four institutions' general dermatology clinics using diagnoses consistent with the International Classification of Disease (ICD), Ninth and Tenth Revisions, codes related to photodermatoses between August 2006 and August 2016. Read More

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[Polymorphic lucite: about a case].

Pan Afr Med J 2019 6;34:12. Epub 2019 Sep 6.

Service de Dermatologie-Vénérologie, Hôpital Militaire d'Instruction Mohammed V, Rabat, Maroc.

Polymorphic lucite (PL) is a frequent photodermatosis, but its pathophysiologic mechanism is still poorly elucidated. We report the case of a 54-year old male teacher, with no previous medical-surgical history, presenting with recurrent papular and very pruritic rash lasting for 12 years. Clinical examination showed papular-vesicular excoriated lesions on the face, the neck and the scalp. Read More

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December 2019

UV-responsive [email protected] nanoparticles potential for polymorphous light eruption protection and therapy.

Mater Sci Eng C Mater Biol Appl 2020 Feb 14;107:110254. Epub 2019 Oct 14.

Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Chongqing, 400044, China; Department of Dermatology, Chongqing First People's Hospital and Chongqing Traditional Chinese Medicine Hospital, Chongqing, 400011, China. Electronic address:

Polymorphous light eruption (PLE) is one of the acquired idiopathic photodermatosis mainly induced by immoderate UV radiation. In order to realize UV protection and medicine administration simultaneously for polymorphous light eruption protection and therapy, Acetyl-11-keto-β-boswellic acid (AKBA) loaded Zinc Oxide (ZnO) nanoparticles of which drug release behavior is UV-controlled has been successfully synthesized. Such nanoparticles can not only reflect UV but also transfer the energy to release AKBA which presents an excellent antioxidant and anti-inflammatory effects. Read More

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February 2020

Phototherapy in the Evaluation and Management of Photodermatoses.

Dermatol Clin 2020 Jan 18;38(1):71-77. Epub 2019 Oct 18.

Department of Dermatology, Henry Ford Health System, 3031 West Grand Boulevard, Suite 800, Detroit, MI 48202, USA. Electronic address:

Ultraviolet light (UV) and visible light are important components in the diagnosis of photodermatoses, and UV has the unique ability to also be used to manage photodermatoses. Phototesting, provocative light testing, and photopatch testing can provide important information in diagnosing patients with photodermatoses; phototesting can be used to determine the starting dose for phototherapy in these patients. Once photosensitivity is established, narrowband UVB and UVA1 therapy have helped to improve the quality of life of photosensitive patients, such as those with polymorphous light eruption, chronic actinic dermatitis, and solar urticaria. Read More

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January 2020

Do We Utilize Our Knowledge of the Skin Protective Effects of Carotenoids Enough?

Antioxidants (Basel) 2019 Jul 31;8(8). Epub 2019 Jul 31.

School of Medicine, University of Zagreb, Šalata 3, 10 000 Zagreb, Croatia.

Due to their potential health-promoting effects, carotenoids have drawn both scientific and public attention in recent years. The primary source of carotenoids in the human skin is diet, mainly fruits, vegetables, and marine product, but they may originate from supplementation and topical application, too. In the skin, they accumulate mostly in the epidermis and act as a protective barrier to various environmental influences. Read More

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Lichenoid pseudovesicular papular eruption on nose: A papular facial dermatosis probably related to actinic lichen nitidus or micropapular polymorphous light eruption.

Indian J Dermatol Venereol Leprol 2019 Nov-Dec;85(6):597-604

Departments of Dermatology, All India Institute of Medical Sciences, New Delhi, India.

Background: Facial papules are a feature of several clinical conditions and may present both diagnostic and therapeutic challenges.

Aim: To describe a grouped papular eruption on the nose and adjoining cheeks that has not been well characterized previously.

Materials And Methods: A series of consecutive patients with a papular eruption predominantly involving nose and cheeks were evaluated, treated and followed up prospectively at tertiary care centers. Read More

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February 2020

Polymorphous light eruption with complication of solar urticaria revealed by phototesting.

J Dermatol 2019 05 10;46(5):e148-e149. Epub 2018 Oct 10.

Department of Dermatology, Kansai Medical University, Osaka, Japan.

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Herbal sun protection agents: Human studies.

Clin Dermatol 2018 May - Jun;36(3):369-375. Epub 2018 Mar 21.

Department of Dermatology, SUNY Downstate Medical Center, Brooklyn, NY.

Topical sunscreens are the mainstay for protection from ultraviolet (UV) radiation. With skin cancer rates on the rise and great interest in reversing or preventing the effects of photoaging, new molecules with potential to defend against UV damage have received a great deal of attention. Specifically, there is a growing interest in herbal substances that offer protection against the damaging effects of UV rays. Read More

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November 2018

Photodermatoses in the Pigmented Skin.

Adv Exp Med Biol 2017 ;996:111-122

Department of Dermatology and Venereology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India.

Skin colour (specifically in relation to its melanin content and composition) has a marked influence on its interaction with ultraviolet light. Eumelanin has mainly photoprotective properties while pheomelanin has the ability to cause formation of reactive oxygen species. This difference is responsible for the difference in incidence and presentation of various idiopathic photodermatoses in dark skinned patients compared to those with lighter skin types. Read More

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Polymorphous Light Eruption.

Adv Exp Med Biol 2017 ;996:61-70

University of Genoa, Genoa, Italy.

Polymorphous light eruption (PLE) is the commonest immuno-mediated photodermatosis. It occurs after solar or artificial UV-light exposure and affects only the sun-exposed areas with preference of the V-area of the chest, of arms and forearms, legs, upper part of the back, and rarely the face. The lesions are itching or burning, and vary morphologically from erythema to papules, vesico-papules and occasionally blisters, plaques, sometimes erythema multiforme-like, insect bite-like wheals and purpura. Read More

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Vitamin D and the Skin: An Update for Dermatologists.

Am J Clin Dermatol 2018 Apr;19(2):223-235

Department of Dermatology, Hôpital Henri Mondor, 51 Avenue du Maréchal de Lattre de Tassigny, 94010, Créteil, France.

Vitamin D plays a key role in skeletal and cardiovascular disorders, cancers, central nervous system diseases, reproductive diseases, infections, and autoimmune and dermatological disorders. The two main sources of vitamin D are sun exposure and oral intake, including vitamin D supplementation and dietary intake. Multiple factors are linked to vitamin D status, such as Fitzpatrick skin type, sex, body mass index, physical activity, alcohol intake, and vitamin D receptor polymorphisms. Read More

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Insight into immunocytes infiltrations in polymorphous light eruption.

Biotechnol Adv 2017 Nov 17;35(6):751-757. Epub 2017 Jul 17.

Department of Dermatology, First Affiliated Hospital of Kunming Medical University, Institute of Dermatology & Venereology of Yunnan Province, Kunming, Yunnan, China. Electronic address:

Polymorphous light eruption (PLE) which is one of the most common photodermatoses has been demonstrated to be immune-mediated disorder. Resistance to UV-induced immunosuppression resulting from differential immune cells infiltration and cytokines secretion has been highlighted in the pathogenesis of PLE. In this study, we reviewed differential patterns of immune cells infiltrations and cytokines secretion that may contribute to PLE occurrence and development. Read More

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November 2017

Recurrent pruritic papules on the elbows as a localized form of polymorphous light eruption.

Clin Exp Dermatol 2017 Aug 22;42(6):708-710. Epub 2017 May 22.

Department of Dermatology, Hospital del Mar-Parc de Salut Mar, Barcelona, Spain.

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