2,904 results match your criteria Polymorphous Light Eruption


Investigating the Pathogenicity of VSX1 Missense Mutations and Their Association With Corneal Disease.

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5824-5835

Department of Biology, University of Victoria, Victoria, British Columbia, Canada.

Purpose: Despite numerous studies associating Visual System Homeobox 1 (VSX1), with posterior polymorphous corneal dystrophy and keratoconus, its role in these diseases is unclear. Here we examine the pathogenicity of VSX1 missense mutations in vitro and in a mouse genetic model.

Methods: Vsx1 transcriptional repressor activity, protein stability, and subcellular localization activity, was examined using luciferase reporter-based assays, western blotting and immunolabeling, respectively, in transfected human embryonic kidney 293T cells. Read More

View Article
December 2018

Acute exudative polymorphous vitelliform maculopathy: To bolus or not to bolus?

Oman J Ophthalmol 2018 Sep-Dec;11(3):280-283

Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Rome, Italy.

Acute exudative polymorphous vitelliform maculopathy (AEPVM) is a rare bilateral maculopathy characterized by chronic and long-term course. We report a case of AEPVM with an unusual presentation and management in a middle-aged man. He presented with clinical features of bilateral AEPVM accompanied by multiple intraretinal cysts, with a sudden increase of intraretinal fluid and visual function deterioration over a span of few days. Read More

View Article
December 2018
1 Read

Malignant Sweat Gland Tumors.

Hematol Oncol Clin North Am 2019 Feb;33(1):53-71

Department of Pathology, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA. Electronic address:

Malignant sweat gland neoplasms are a confusing area within dermatopathology, with many entities reported under several designations in the literature. This review describes the key clinical and histopathologic features of select malignant adnexal neoplasms, including porocarcinoma, papillary carcinoma, adenoid cystic carcinoma, cribriform carcinoma, apocrine hidradenocarcinoma, malignant mixed tumor of the skin, syringoid carcinoma, cylindrocarcinoma, spiradenocarcinoma, mucinous carcinoma, polymorphous sweat gland carcinoma, microcystic adnexal carcinoma, secretory carcinoma of the skin, and primary cutaneous signet ring cell carcinoma. For entities with overlapping features, differential diagnoses are discussed. Read More

View Article
February 2019
1 Read

Comparison of p63/p40 Expression With Myoepithelial Markers in Minor Salivary Gland Tumors.

Int J Surg Pathol 2018 Nov 27:1066896918813678. Epub 2018 Nov 27.

1 São Leopoldo Mandic Institute and Research Center, Campinas, São Paulo, Brazil.

The present study aimed to compare the expression of p63/p40 with smooth muscle actin (SMA) and vimentin (VIM) by myoepithelial cells in minor salivary gland tumors. Fifty-two formalin-fixed paraffin-embedded samples of minor salivary gland tumors derived from intercalated duct (pleomorphic adenoma [PA], adenoid cystic carcinoma [ACC], epithelial-myoepithelial carcinoma [EMC], polymorphous adenocarcinoma [PAC], and secretory carcinoma [SC]) and 3 samples of minor salivary gland tumors derived from excretory duct (mucoepidermoid carcinoma [MEC]) were evaluated by means of immunohistochemistry. The data were analyzed qualitatively. Read More

View Article
November 2018
1 Read

[Non-type b Haemophilus influenzae: a rare cause of meningitis in an infant with a guarded prognosis].

Pan Afr Med J 2018 22;30:164. Epub 2018 Jun 22.

Service de Microbiologie, CHU Mohammed VI, Faculté de Médecine et de Pharmacie, Université Cadi Ayyad, Marrakech, Maroc.

Non-Type b Haemophilus is a rare cause of invasive secondary localization in young children. We here report the case of a child aged 11 months old who had Meningitis due to Non-Type b Haemophilus, a gram -negative bacilli of polymorphous appearance still exceptionally described in the literature, whose origin was undetermined and whose evolution was fatal. Clinicians and microbiologists should suspect the presence of these infrequent serotypes, especially on a particular case. Read More

View Article
December 2018
1 Read

Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma arising in patient with a history of EBV-positive mucocutaneous ulcer and EBV-positive nodal polymorphous B-lymphoproliferative disorder.

Pathol Int 2018 Nov 19. Epub 2018 Nov 19.

Department of Pathology and Laboratory Medicine, Nagoya University Hospital, Nagoya, Japan.

Elderly patients with Epstein-Barr virus (EBV) infection are at increased risk for developing B-cell lymphoproliferative disorder (B-LPD) due to immunosenescence. Here, we describe a case of a 75-year-old man who developed an EBV-positive (EBV+) mucocutaneous ulcer (EBVMCU) in the gingiva with spontaneous regression. Eighteen months after regression, he had a cervical lymph node enlargement that was diagnosed as EBV+ nodal polymorphous B-LPD, Ann Arbor stage IA. Read More

View Article
November 2018
9 Reads

Masked pemphigus among pediatric patients with Castleman's disease.

Int J Rheum Dis 2018 Nov 8. Epub 2018 Nov 8.

Department of Pathology, Taichung Veterans General Hospital, Taichung, Taiwan.

Aim: Paraneoplastic pemphigus (PNP) is a mucocutaneous autoimmune disorder accompanied with a neoplasm. Castleman's disease (CD), although rare, is the most common cause of PNP in children. It can be life-threatening when pulmonary involvement occurs. Read More

View Article
November 2018
6 Reads

Xeroderma pigmentosum.

Ann Dermatol Venereol 2018 Nov 6;145(11):706-722. Epub 2018 Nov 6.

Service de dermatologie, Hôpital La Rabta, Tunis, Tunisie; Unité de recherche UR 12SP07, Hôpital La Rabta, Tunis, Tunisie. Electronic address:

Xeroderma pigmentosum (XP) is a form of general dermatosis characterised by photo-induced cutaneous-ocular impairment and by skin cancers. In addition to these signs, there may also be neurological involvement. This disease is related to a defect in genes within the nucleotide excision repair system for the first seven genetic groups (A-G), and to an abnormality in transcription groups for the eighth group (xeroderma pigmentosum variant - XPV). Read More

View Article
November 2018
4 Reads

Torticollis as Presentation for Atypical Kawasaki Disease Complicated by Giant Coronary Artery Aneurysms.

Case Rep Pediatr 2018 8;2018:4236264. Epub 2018 Oct 8.

Department of Pediatrics, Memorial University, 300 Prince Phillip Drive, St. John's, NL, Canada A1B 3V6.

Kawasaki disease (KD) is an acute systemic vasculitis of childhood. The diagnosis can be made in a patient who presents with a prolonged high fever and meeting at least four of five criteria including polymorphous rash, mucosal changes, extremity changes (including swelling and/or palmar and plantar erythema), bilateral nonsuppurative conjunctivitis, and unilateral cervical lymphadenopathy. Atypical KD refers to patients who have not met the full criteria and in whom atypical features may be present. Read More

View Article
October 2018
7 Reads

Cryptococcus-like changes in the setting of vasculitis.

J Cutan Pathol 2018 Oct 25. Epub 2018 Oct 25.

Department of Medicine, Division of Dermatology, Albert Einstein College of Medicine/Montefiore Medical Center, New York, New York.

Cutaneous vasculitis has many underlying causes, and the clinical and histological findings often overlap. Inflammatory vasculitis can mimic infection; however, distinction is critical for the timely institution of appropriate therapy. We present two patients who had generalized polymorphous eruptions whose cutaneous pathology showed vasculitis with unusual haloed yeast-like cells within the inflammatory infiltrate, mimicking Cryptococcus. Read More

View Article
October 2018
4 Reads

Porosity Properties of the Conformers of Sodalite-like Zeolitic Imidazolate Frameworks.

J Am Chem Soc 2018 Nov 25;140(44):14586-14589. Epub 2018 Oct 25.

Department of Chemistry , Soongsil University , 369 Sangdo-Ro , Dongjak-Gu, Seoul 06978 , Republic of Korea.

The conformational isomers of zeolitic imidazolate frameworks (ZIFs) can have their own unique porosity and structural stability. We report that a new sodalite-like ZIF (termed β-ZIF-65(Zn)) is polymorphous with as the existing ZIF-65(Zn) (Zn(nIm), nIm = 2-nitroimidazolate) but has a different linker conformation in the six-membered rings of sodalite cages. This conformational isomerism leads to distinctive permanent porosity for each conformer, which has been verified by gas adsorption measurements. Read More

View Article
November 2018
5 Reads

Expression of α-smooth muscle actin in benign and malignant salivary gland tumors: An immunohistochemical study.

Indian J Pathol Microbiol 2018 Oct-Dec;61(4):479-484

Department of Oral Pathology and Microbiology, Manipal College of Dental Sciences, Manipal Academy of Higher Education, Mangalore, Karnataka, India.

Background And Objectives: Myoepithelial cells (ME) are known to contribute in the patterning of salivary gland neoplasms (SGN) and possess cytoplasmic smooth muscle actin (SMA) revealed by alpha SMA (α-SMA). The present study aimed to assess the expression of α-SMA in selected benign and malignant SGN (pleomorphic adenoma [PA], mucoepidermoid carcinoma (MEC), adenoid cystic carcinoma (ACC), and polymorphous low-grade adenocarcinoma (PLGA).

Materials And Methods: The intensity and pattern of expression of α-SMA were studied in 25 cases of SGN's ACC (n = 7), MEC (n = 8), PA (n = 8), and PLGA (n = 2), and correlated with the histological patterns. Read More

View Article
October 2018
2 Reads

Polymorphous light eruption with complication of solar urticaria revealed by phototesting.

J Dermatol 2018 Oct 10. Epub 2018 Oct 10.

Department of Dermatology, Kansai Medical University, Osaka, Japan.

View Article
October 2018
5 Reads

Infliximab as an alternative therapy for refractory adult onset Kawasaki disease: A case report.

Medicine (Baltimore) 2018 Oct;97(40):e12720

Department of Rheumatology, Infectious Diseases and Laboratory Medicine.

Rationale: Kawasaki disease (KD) is an acute febrile illness predominantly affecting children less than 5 years of age and characterized by systemic inflammation in all medium-sized arteries. Adult-onset KD (AKD) is rare with only 105 case reports published. Recently, the efficacy of infliximab (IFX) for patients with refractory KD has been demonstrated. Read More

View Article
October 2018
2 Reads

Adenoid cystic carcinoma: A study of 19 cases of salivary and extra-salivary tumours diagnosed by fine needle aspiration cytology.

Diagn Cytopathol 2018 Oct 3. Epub 2018 Oct 3.

Department of Pulmonary Medicine, Government Medical College and Hospital, Chandigarh, India.

Background: Adenoid cystic carcinoma (ACC) arises at sites where seromucinous or sweat gland epithelium is present and commonly affects the salivary glands. Rarely it can occur at extra-salivary locations.

Methods: A retrospective analysis of 19 cases of ACC diagnosed on fine needle aspiration cytology (FNAC) over a period of 15 y (2002-2016) was made. Read More

View Article
October 2018
8 Reads

P120 catenin expression and its correlation with E-cadherin in salivary gland neoplasms.

J Oral Biol Craniofac Res 2019 Jan-Mar;9(1):57-62. Epub 2018 Sep 14.

Faculty of Dentistry, Chulalongkorn University, Henri-Dunant Road, Pathumwan, Bangkok, 10330, Thailand.

Objectives: Altered P120 catenin expression has been associated with E-cadherin loss and poor prognosis in several cancers. The objectives of this study were to examine the P120 catenin expression in salivary gland neoplasms in correlation with E-cadherin and assess the relationships between their expression levels and pathologic characteristics.

Methods: Fifty-two cases of salivary gland neoplasms, i. Read More

View Article
September 2018
2 Reads

Genetic Aspects of Keratoconus: A Literature Review Exploring Potential Genetic Contributions and Possible Genetic Relationships with Comorbidities.

Ophthalmol Ther 2018 Dec 6;7(2):263-292. Epub 2018 Sep 6.

Association for Training in Biomedical Technology, Thessaloníki, Greece.

Introduction: Keratoconus (KC) is a complex, genetically heterogeneous, multifactorial degenerative disorder that is accompanied by corneal ectasia which usually progresses asymmetrically. With an incidence of approximately 1 per 2000 and 2 cases per 100,000 population presenting annually, KC follows an autosomal recessive or dominant pattern of inheritance and is, apparently, associated with genes that interact with environmental, genetic, and/or other factors. This is an important consideration in refractive surgery in the case of familial KC, given the association of KC with other genetic disorders and the imbalance between dizygotic twins. Read More

View Article
December 2018
4 Reads

Multidisciplinary management of patients presenting with Lyme disease suspicion.

Med Mal Infect 2018 Sep 3. Epub 2018 Sep 3.

Service de maladies infectieuses et tropicales, CHRU de Nancy, rue du Morvan, 54500 Vandoeuvre-les-Nancy, France.

Objective: The teaching hospital of Nancy, France, implemented a specific multidisciplinary care pathway (French acronym AMDPL) to improve the management of patients presenting with Lyme borreliosis (LB) suspicion. We aimed to assess the first year of activity of this care pathway.

Patients And Methods: We included all patients managed in the AMDPL pathway from November 1, 2016 to October 31, 2017. Read More

View Article
September 2018
8 Reads

Historical Evolution of the Polymorphous Adenocarcinoma.

Head Neck Pathol 2018 Sep 5. Epub 2018 Sep 5.

Department of Anatomic Pathology, Moffitt Cancer Center, Tampa, FL, USA.

The 2017 World Health Organization Classification of Head and Neck Tumors introduced for the first time the diagnostic terminology "cribriform variant of polymorphous adenocarcinoma". This nomenclature attempts to reconciliate the ongoing taxonomical controversy related to cribriform adenocarcinoma of tongue. In order to better understand this classification conundrum, it is imperative for pathologist to comprehend the historical evolution of polymorphous adenocarcinoma formerly known as polymorphous "low grade" adenocarcinoma. Read More

View Article
September 2018
2 Reads

Intrapancreatic accessory spleen. Report of four cases diagnosed by ultrasound-guided fine-needle aspiration biopsy.

Rom J Morphol Embryol 2018 ;59(2):619-624

Pathology Unit, Department of Medical and Surgical Sciences, University of Cantabria and IDIVAL Research Institute, Santander, Spain;

Intrapancreatic accessory spleen (IPAS) is a congenital anomaly usually misdiagnosed as a pancreatic neoplasm. For five years and four months, we collected seven IPASs located in the tail of the pancreas in four patients diagnosed by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA). All cases had associated cell block preparations. Read More

View Article
December 2018

Immunohistochemical study of salivary gland tumors in a tertiary institution in South-South Region of Nigeria.

J Oral Maxillofac Pathol 2018 May-Aug;22(2):163-167

Department of Oral Pathology, UPTH, Port Harcourt, Nigeria.

Aim: The aim of this study was to see the usefulness of immunohistochemistry in diagnosing salivary gland tumors found in a tertiary health institution.

Materials And Methods: Twenty-six formalin-fixed paraffin embedded salivary gland tumors were accessioned, and 2 μm were sectioned and processed using Streptavidin-Biotin immunoperoxidase method.

Results: Adenoid cystic carcinoma (ADCC) was positive to alpha-smooth muscle actin (α-SMA) while mucoepidermoid carcinoma (MEC), polymorphous low-grade adenocarcinoma (PLGA), squamous cell carcinoma (SCC) and oncocytic carcinoma (OCC) were all negative to it. Read More

View Article
August 2018
7 Reads

Clinical findings observed by in-vivo confocal microscopy of posterior polymorphous corneal dystrophy.

J Fr Ophtalmol 2018 Sep 23;41(7):e301-e302. Epub 2018 Aug 23.

Lithuanian University of Health Sciences, A. Mickevičiaus g. 9, Kaunas 44307, Lituanie.

View Article
September 2018
9 Reads

Dermoscopy improves diagnostic accuracy for clinically amelanotic nodules.

Australas J Dermatol 2018 Aug 19. Epub 2018 Aug 19.

Victorian Melanoma Service, Alfred Hospital, Melbourne, Victoria, Australia.

Background/objectives: Amelanotic nodular melanomas are notoriously difficult to diagnose and are responsible for a disproportionate burden of melanoma mortality. It is important to distinguish them from other amelanotic nodules. This study aimed to describe the dermoscopic features of a series of nodular melanomas and other amelanotic nodules and to determine whether dermoscopy improves diagnostic accuracy. Read More

View Article
August 2018
10 Reads
0.980 Impact Factor

Genetic heterogeneity and mutational signature in Chinese Epstein-Barr virus-positive diffuse large B-cell lymphoma.

PLoS One 2018 14;13(8):e0201546. Epub 2018 Aug 14.

Department of Pathology, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong Province, China.

Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma (EBV+ DLBCL) is typically an aggressive tumor in elderly patients. However, in a subset of young patients, EBV+ DLBCL follows a relatively indolent clinical course and exhibits a good response to chemotherapy. This lymphoma comprises polymorphous lymphoma and large cell lymphomas subtypes, with the latter subtype showing a significantly poorer prognosis. Read More

View Article
August 2018
3 Reads
3.230 Impact Factor

Paraneoplastic autoimmune multiorgan syndrome (PAMS): Beyond the single phenotype of paraneoplastic pemphigus.

Autoimmun Rev 2018 Oct 11;17(10):1002-1010. Epub 2018 Aug 11.

Department of Dermatology, University of California Irvine, Irvine, CA, USA; Institute for Immunology and Departments of Dermatology and Biological Chemistry, University of California, Irvine, CA, USA.

Paraneoplastic autoimmune multiorgan syndrome (PAMS) is characterized by a heterogenous group of signs and symptoms including severe desquamative stomatitis, a polymorphous cutaneous eruption, humoral immunity against plakin proteins, contribution of cell-mediated autoimmunity and commonly a progressive respiratory failure. Autoantibodies in PAMS target a wide array of antigens including plakins, cadherins, alpha-2-macroglobulin like 1 (A2ML1), BP180, plakophilin-3, and several neuromuscular antigens. Originally described as paraneoplastic pemphigus in 1990 due to some of its clinical and immunologic similarities to classic pemphigus (pemphigus vulgaris and pemphigus foliaceus), PAMS is a multiorganopathy with several distinct features from these classic forms of pemphigus. Read More

View Article
October 2018
3 Reads

Incomplete Refractory Kawasaki Disease in an Infant-A Case Report and a Review of the Literature.

Front Pediatr 2018 27;6:210. Epub 2018 Jul 27.

Department of Pediatrics, University of Medicine and Pharmacy TîrguMures, Târgu Mures, Romania.

Kawasaki disease (KD) is a febrile vasculitis, which is commonly defined by fever and at least four specific clinical symptoms. Incomplete KD is defined by suggestive echocardiographic findings with an incomplete clinical picture. Refractory KD is diagnosed in patients resistant to intravenous immunoglobulin (IVIG). Read More

View Article
July 2018
2 Reads

Re-evaluation of "Polymorphous Sweat Gland Carcinoma".

Authors:
Keisuke Goto

Am J Dermatopathol 2018 Aug 6. Epub 2018 Aug 6.

Department of Pathology and Cytology, Karolinska University Hospital, Huddinge, Sweden.

View Article
August 2018
7 Reads

Chromoblastomycosis: an etiological, epidemiological, clinical, diagnostic, and treatment update.

An Bras Dermatol 2018 Jul-Aug;93(4):495-506

Dermatology Course, Universidade Federal do Pará, Belém (PA), Brazil.

Chromoblastomycosis is a chronic, granulomatous, suppurative mycosis of the skin and subcutaneous tissue caused by traumatic inoculation of dematiaceous fungi of the family Herpotrichiellaceae. The species Fonsecaea pedrosoi and Cladophialophora carrionii are prevalent in regions where the disease is endemic. Chromoblastomycosis lesions are polymorphous: verrucous, nodular, tumoral, plaque-like, and atrophic. Read More

View Article
September 2018
7 Reads

Low-grade neuroepithelial tumor: Unusual presentation in an adult without history of seizures.

Neuropathology 2018 Oct 26;38(5):557-560. Epub 2018 Jul 26.

Pathology Unit, Department of Diagnostics and Public Health, University and Hospital Trust of Verona, Verona, Italy.

Low-grade neuroepithelial tumors (LGNT) show a broad histopathological spectrum and may be difficult to classify using current World Health Organization (WHO) criteria. A 57-year-old man came to medical attention because of headaches. The patient medical history was otherwise unremarkable. Read More

View Article
October 2018
9 Reads

Polymorphous Cutaneous Sarcoidosis Associated with Peripheral Vascular Disease and its Dermatoscopic Findings.

Indian Dermatol Online J 2018 Jul-Aug;9(4):256-258

Department of Pathology, Christian Medical College, Vellore, Tamil Nadu, India.

Sarcoidosis is a multisystem disorder with cutaneous involvement with myriad of morphological presentations, often leading to diagnostic dilemma. We report a case of 31-year-old male with peripheral arterial disease who presented with three morphological forms of sarcoidosis simultaneously, namely, papular, psoriasiform, and pigmented purpuric dermatosis-like lesions. Dermatoscopy of cutaneous lesions showed yellow-orange globules, red dots, linear vessels, and white crystalline structures depending on the clinical forms. Read More

View Article
July 2018
1 Read

The Visible and Less Visible in the Suffering of a Conversion Disorder in Children and Adolescents. A Qualitative Study of Illness Explanatory Models Presented to Caregivers of Children and Adolescents with Conversion Disorder.

Rev Colomb Psiquiatr 2018 Jul - Sep;47(3):155-164. Epub 2017 Mar 30.

Hospital de la Misericordia, Universidad Nacional de Colombia, Bogotá, Colombia.

Background: Conversion disorder is a challenge for clinicians due to the conceptual gaps as regards its pathogenesis, the way in which it converges with other psychiatric disorders, and the lack of approaches to the experiences of both patients and family members with the disease.

Objective: To describe Explanatory Models (EM) offered to caregivers of paediatric patients with conversion disorder who attended the Hospital de la Misericordia.

Methods: A qualitative study was conducted with a convenience sample of 10 patients who attended the Hospital de La Misericordia, ¿Bogota? between May 2014 and April 2015. Read More

View Article
March 2017
1 Read

Bullous pemphigoid with hyperkeratosis and palmoplantar keratoderma: Three cases.

J Dermatol 2018 Sep 14;45(9):1135-1140. Epub 2018 Jul 14.

Istituto Dermopatico dell'Immacolata-IRCCS, FLMM, Rome, Italy.

The clinical features of bullous pemphigoid are extremely polymorphous. Several atypical forms of bullous pemphigoid have been described, and the diagnosis critically relies on immunopathological findings. We describe three bullous pemphigoid patients characterized by palmoplantar keratoderma, diffused hyperkeratotic cutaneous lesions and extremely high levels of immunoglobulin E serum. Read More

View Article
September 2018
2 Reads

Predictors of intravenous immunoglobulin-resistant Kawasaki disease in children: a meta-analysis of 4442 cases.

Eur J Pediatr 2018 Aug 8;177(8):1279-1292. Epub 2018 Jun 8.

Department of Cardiology, Children's Hospital of Soochow University, Suzhou, 215003, China.

The purpose of this study was to identify the clinical features and laboratory factors that are predictive of intravenous immunoglobulin (IVIG)-resistant Kawasaki disease. Multiple databases were searched for relevant studies on IVIG-resistant Kawasaki disease published from January 2002 to April 2017. Eligible studies were retrieved by manual review of the references. Read More

View Article
August 2018
7 Reads

Cancer Immunotherapy and the Immune Response in Hodgkin Lymphoma.

Front Oncol 2018 4;8:193. Epub 2018 Jun 4.

Department of Oncology, University Hospital Basel, Basel, Switzerland.

Patients with classical Hodgkin lymphoma (cHL) have an impaired cellular immune response as indicated by an anergic reaction against standard recall antigens and a diminished rejection reaction of allogeneic skin transplant. This clinical observation can be linked to the histopathological feature of cHL since the typical pattern of a cHL manifestation is characterized by sparse large CD30 tumor-infiltrating Hodgkin-Reed-Sternberg (HRS) cells that are surrounded by a dense inflammatory immune microenvironment with mixed cellularity. Despite this extensive polymorphous inflammatory infiltrate, there is only a poor antitumor immune response seen to the neoplastic HRS cells. Read More

View Article
June 2018
13 Reads

Herbal sun protection agents: Human studies.

Clin Dermatol 2018 May - Jun;36(3):369-375. Epub 2018 Mar 21.

Department of Dermatology, SUNY Downstate Medical Center, Brooklyn, NY.

Topical sunscreens are the mainstay for protection from ultraviolet (UV) radiation. With skin cancer rates on the rise and great interest in reversing or preventing the effects of photoaging, new molecules with potential to defend against UV damage have received a great deal of attention. Specifically, there is a growing interest in herbal substances that offer protection against the damaging effects of UV rays. Read More

View Article
November 2018
19 Reads

Same building block, but diverse surface-confined self-assemblies: solvent and concentration effects-induced structural diversity towards chirality and achirality.

Phys Chem Chem Phys 2018 Jun;20(25):17367-17379

College of Materials Science and Engineering, South China University of Technology, Guangzhou 510640, China.

Fabricating complex nano-networks on solid substrates is a research area that has attracted much attention in the field of molecular self-assembly. By designing a fluorenone derivative of 2-heptyloxy-7-pentadecyloxy-9-fluorenone (HPF), we obtained a surface-confined system that presented diverse nanostructures. The assembled networks for HPF were highly dependent on the solvent and concentration. Read More

View Article
June 2018
15 Reads

Interdigitating dendritic cell tumor: A rare case report with review of literature.

J Cancer Res Ther 2018 Apr-Jun;14(3):690-693

Department of Medical and Pediatric Oncology, GCRI, Ahmedabad, Gujarat, India.

Interdigitating dendritic cell tumor/sarcoma (IDCT) is a very rare and aggressive neoplasm arising from antigen-presenting cells. It usually involves lymph nodes, but extranodal sites can also be involved. Because of the rarity of the disease, consistent standard treatment guidelines have not been established till date. Read More

View Article
November 2018
1 Read

[Paraneoplastic Syndromes in Ophthalmology (French version of the article)].

J Fr Ophtalmol 2018 Jun 9;41(6):554-559. Epub 2018 Jun 9.

Université Rennes, INSERM, INRA, CHU de Rennes, Institut NUMECAN (Nutrition Metabolisms and Cancer), 35000 Rennes, France. Electronic address:

Paraneoplastic syndromes involving the visual system are a heterogeneous group of disorders occurring in the setting of systemic malignancy. Although these syndromes are rare, the clinical manifestations can herald an unsuspected, underlying malignancy. The associated antibodies and histopathology of each syndrome are presented to help in the understanding of these autoimmune phenomena. Read More

View Article
June 2018
2 Reads

Mimickers of Urticaria: Urticarial Vasculitis and Autoinflammatory Diseases.

J Allergy Clin Immunol Pract 2018 Jul - Aug;6(4):1162-1170. Epub 2018 Jun 2.

Department of Infectious Diseases and Immunity, Jessa Hospital. BIOMED Research Institute, University of Hasselt, Hasselt, Belgium.

A wide differential diagnosis must be considered in a patient presenting with urticarial plaques. Although acute and chronic urticaria are the commonest diagnoses, other differential diagnoses include polymorphous eruption of pregnancy, mast cell disorders, hypereosinophilic syndrome, urticarial vasculitis, pemphigoid, systemic lupus erythematosus, and autoinflammatory disease. This review will specifically address urticarial vasculitis and autoinflammatory syndromes. Read More

View Article
June 2018
6 Reads

Immunohistochemical Expression of CD-117 (c-KIT), P-53 and Ki-67 in Adenoid Cystic Carcinoma of Palate.

J Coll Physicians Surg Pak 2018 Jun;28(6):S130-S132

Department of Oral and Maxillofacial Pathology, NIMS Dental College, Jaipur, India.

Adenoid cystic carcinoma (ACC) is a malignant tumor of salivary glands characterized histopathologically by biphasic epithelial tumor comprised of myoepithelial and ductal cells. There is a paucity of the literature regarding the immunohistochemical labelling of ACC arising in minor salivary glands. This paper reports an additional case of palatal ACC with an emphasis on its immunohistochemical staining using three different markers. Read More

View Article
June 2018
0.320 Impact Factor

Urticarial Lesions in a Pregnant Woman.

Acta Dermatovenerol Croat 2018 Apr;26(1):71-72

Sergio Santos-Alarcon, MD, Department of Dermatology, , Hospital Universitario Doctor Peset, Avinguda Gaspar Aguilar Nº 90, 4601 Valencia, Spain;

Dear Editor, Gestational pemphigoid (GP) is a rare autoimmune bullous dermatosis in pregnancy. GP usually occurs during the second or third month of pregnancy. It clinically manifests as the development of either early-onset urticarial lesions or late-onset subepidermal blisters that may linger for weeks or even months. Read More

View Article
April 2018
6 Reads

Polymorphous adenocarcinoma of the salivary glands: reappraisal and update.

Eur Arch Otorhinolaryngol 2018 Jul 14;275(7):1681-1695. Epub 2018 May 14.

International Head and Neck Scientific Group, Padua, Italy.

Although relatively rare, polymorphous adenocarcinoma (PAC) is likely the second most common malignancy of the minor salivary glands (MiSG). The diagnosis is mainly based on an incisional biopsy. The optimal treatment comprises wide surgical excision, often with adjuvant radiotherapy. Read More

View Article
July 2018
3 Reads

Effect of Posterior Corneal Vesicles on Corneal Endothelial Cell Density and Anisometropic Amblyopia.

Cornea 2018 Jul;37(7):813-817

Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Purpose: To evaluate the effect of corneal vesicles in patients with posterior corneal vesicles (PCV) on corneal endothelial cell (CEC) density and the acquisition of amblyopia.

Methods: In this retrospective study of patients with PCV (18 eyes of 14 patients), CEC density was examined by noncontact specular microscopy during each follow-up examination. Best-corrected visual acuity and the objective refractive error were also examined. Read More

View Article
July 2018
2 Reads

A polymorphous rash of an uncommon blistering disease.

Clin Exp Dermatol 2018 10 10;43(7):839-842. Epub 2018 May 10.

Dermatology Department, National Skin Centre, Singapore, Singapore.

View Article
October 2018

A newly diagnosed case of polymorphous low-grade neuroepithelial tumor of the young.

Clin Neuropathol 2018 Jul/Aug;37(4):178-181

Polymorphous low-grade neuroepithelial tumor of the young (PLNTY) is a recently described variant of low-grade neuroepithelial tumors that exhibits infiltrative growth, histopathological variability with frequently prominent oligodendroglioma-like components, intense labeling for CD34, absence of 1P/19Q codeletion, a distinct DNA methylation signature and genetic alterations involving MAP kinase pathway constituents of either the B-Raf proto-oncogene BRAF or fibroblast growth factor receptors 2 or 3 (FGFR2 and FGFR3). We here report a newly diagnosed case of PLNTY involving the temporal lobe in a 31-year-old man with chronic focal epilepsy. This tumor had histologic and immunophenotypic features similar to the recently described PLNTY and proved BRAF V600E mutant. Read More

View Article
November 2018
4 Reads

Multiple feature use in pigeons' category discrimination: The influence of stimulus set structure and the salience of stimulus differences.

J Exp Psychol Anim Learn Cogn 2018 Apr;44(2):114-127

Department of Psychology, University of Exeter.

Two experiments investigated what makes it more likely that pigeons' behavior will come under the control of multiple relevant visual stimulus dimensions. Experiment 1 investigated the effect of stimulus set structure, using a conditional discrimination between circles that differed in both hue and diameter. Two training conditions differed in whether hue and diameter were correlated in the same way within positive and negative stimulus sets as between sets. Read More

View Article

Conversion of a rice CMS maintainer into a photo- or thermo-sensitive genetic male sterile line.

Mol Breed 2018 18;38(5):56. Epub 2018 Apr 18.

State key Laboratory of Hybrid rice, Hunan Hybrid Rice Research Center, Changsha, 410125 China.

A maintainer line of 3-line hybrid rice commonly presents a certain genetic distance to a 2-line restorer line, but in many cases, 2-line restorer lines present defects upon recovery of the object cytoplasmic male sterile (CMS) line of the maintainer line, which impedes the utilization of their heterosis. Here, we report a strategy and an example of converting a maintainer into a photoperiod/temperature-sensitive genic male sterile (P/TGMS) line with an almost identical genetic background, thus maximizing the heterosis. Firstly, through treatment of maintainer line T98B with C-γ irradiation, we identified the TGMS line T98S, which is sterile at higher temperatures and fertile at lower temperatures. Read More

View Article
April 2018
2 Reads

[Primary cutaneous CD30+ T-cell lymphoproliferation during treatment with fingolimod: Case report and literature review].

Ann Dermatol Venereol 2018 Jun - Jul;145(6-7):433-438. Epub 2018 Apr 17.

Service de dermatologie et d'allergologie, hôpital Tenon, AP-HP, 4, rue de la Chine, 75020 Paris, France; Faculté de médecine, Sorbonne université, 75013 Paris, France. Electronic address:

Background: Fingolimod is an oral immunomodulator approved for relapsing-remitting multiple sclerosis. We report a case of a primary cutaneous CD30+ T-cell lymphoproliferation occurring 6 months after initiation of fingolimod. Based on a systematic literature review, the characteristics of these fingolimod-induced lymphoproliferative disorders are described. Read More

View Article
April 2018
4 Reads