3,664 results match your criteria Polyhydramnios


[Bartter-Gitelman syndromes].

Nephrol Ther 2020 Jul 1. Epub 2020 Jul 1.

Département de génétique, hôpital européen Georges-Pompidou, 20, rue Leblanc, 75015 Paris, France; Centre de Référence de maladies rénales rares de l'enfant et de l'adulte (MARHEA), Paris, France.

Bartter-Gitelman syndromes are rare inherited autosomal recessive salt-losing tubulopathies characterized by severe and chronic hypokalemia associated with metabolic alkalosis and secondary hyperaldosteronism. Bartter syndrome results from a furosemide-like defect in sodium reabsorption in the Henle's loop leading to hypercalciuria and defect in urinary concentration capacity. The antenatal Bartter syndrome is defined by polyhydramnios and an infantile polyuria with severe dehydration whereas classic Bartter syndrome appears during childhood or adulthood. Read More

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http://dx.doi.org/10.1016/j.nephro.2020.06.001DOI Listing

A homozygous variant in growth and differentiation factor 2 (GDF2) may cause lymphatic dysplasia with hydrothorax and nonimmune hydrops fetalis.

Am J Med Genet A 2020 Jul 2. Epub 2020 Jul 2.

Department of Clinical Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

The etiology of nonimmune hydrops fetalis is extensive and includes genetic disorders. We describe a term-born female neonate with late onset extensive nonimmune hydrops, that is, polyhydramnios, edema, and congenital bilateral chylothorax. This newborn was successfully treated with repetitive thoracocentesis, total parenteral feeding, octreotide intravenously and finally surgical pleurodesis and corticosteroids. Read More

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http://dx.doi.org/10.1002/ajmg.a.61743DOI Listing

Prenatal exposure to isolated amniotic fluid disorders and the risk for long-term endocrine morbidity of the offspring.

Arch Gynecol Obstet 2020 Jun 29. Epub 2020 Jun 29.

Department of Obstetrics and Gynecology, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, POB 151, 84101, Beer-Sheva, Israel.

Background: Amniotic fluid abnormalities may be associated with adverse perinatal outcomes, some of which are endocrine related.

Objective: To evaluate whether in utero exposure to amniotic fluid abnormalities is associated with long-term endocrine morbidity in the offspring.

Study Design: In this cohort study, the incidence of long-term endocrine disorders was compared between singletons exposed and non-exposed to oligohydramnios or polyhydramnios. Read More

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http://dx.doi.org/10.1007/s00404-020-05674-4DOI Listing
June 2020
1.279 Impact Factor

Transient hyponatremia of prematurity caused by mild Bartter syndrome type II: a case report.

BMC Pediatr 2020 Jun 26;20(1):311. Epub 2020 Jun 26.

Department of Pediatrics, Schulich School of Medicine and Dentistry, University of Western Ontario, 1151 Richmond Street, London, ON, N6A5C1, Canada.

Background: Bartter syndrome subtypes are a group of rare renal tubular diseases characterized by impaired salt reabsorption in the tubule, specifically the thick ascending limb of Henle's loop. Clinically, they are characterized by the association of hypokalemic metabolic alkalosis, hypercalciuria, nephrocalcinosis, increased levels of plasma renin and aldosterone, low blood pressure and vascular resistance to angiotensin II. Bartter syndrome type II is caused by mutations in the renal outer medullary potassium channel (ROMK) gene (KCNJ1), can present in the newborn period and typically requires lifelong therapy. Read More

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http://dx.doi.org/10.1186/s12887-020-02214-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318402PMC

The Efficacy and Efficiency of Uterocervical Angle Measurements to Predict Preterm Labor in Idiopathic Polyhydramnios Patients: A Prospective Cohort Study.

Z Geburtshilfe Neonatol 2020 Jun 26. Epub 2020 Jun 26.

Perinatology, Department of Obstetrics and Gynecology, Division of Perinatology, Sanliurfa Training and Research Hospital, Sanlıurfa, Turkey.

Introduction: Uterocervical angle measurements in pregnant women with idiopathic polyhydramnios were appraised for their predictive value for spontaneous preterm labor.

Material And Methods: In this prospective study, we included nulliparous and multiparous pregnant women diagnosed with idiopathic polyhydramnios at 24-28 weeks at our polyclinic; the uterocervical angle and cervical length were measured by transvaginal ultrasound at the time of diagnosis. Routine pregnancy follow-up was done by our team and gestational age at delivery and maternal-fetal outcomes were noted. Read More

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http://dx.doi.org/10.1055/a-1176-2390DOI Listing

GENETICS IN ENDOCRINOLOGY Pathophysiology, diagnosis and treatment of familial nephrogenic diabetes insipidus.

Authors:
Daniel G Bichet

Eur J Endocrinol 2020 Aug;183(2):R29-R40

For an endocrinologist, nephrogenic diabetes insipidus (NDI) is an end-organ disease, that is the antidiuretic hormone, arginine-vasopressin (AVP) is normally produced but not recognized by the kidney with an inability to concentrate urine despite elevated plasma concentrations of AVP. Polyuria with hyposthenuria and polydipsia are the cardinal clinical manifestations of the disease. For a geneticist, hereditary NDI is a rare disease with a prevalence of five per million males secondary to loss of function of the vasopressin V2 receptor, an X-linked gene, or loss of function of the water channel AQP2. Read More

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http://dx.doi.org/10.1530/EJE-20-0114DOI Listing

Prevention of perinatal complications in pregnant women with chronic papillomavirus infection.

Pol Merkur Lekarski 2020 Jun;48(285):157-161

I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine.

Social trends, a new style of modern young woman, which includes the polygamy of sexual relationships, increases the incidence and probability of infection caused by sexually transmitted pathogens, including the human papillomavirus. In women entered into motherhood with chronic papillomavirus carrier, pregnancy is accompanied with an increase in obstetrics and perinatal complications. The inability to use antiviral therapy due to its embryo- and fetotoxic effects requires searching for safe agents for timely and effective preconceptional and prenatal preparation for the fetal infection prevention. Read More

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Sacrococcygeal teratoma with preterm delivery: a case report.

J Med Case Rep 2020 Jun 19;14(1):72. Epub 2020 Jun 19.

Gynecology and Obstetrics Department, Corporació Sanitària Parc Taulí, Parc Taulí s/n, 08208, Sabadell, Spain.

Background: Sacrococcygeal teratoma is one of the most frequently prenatally diagnosed neoplasias. Obstetric ultrasound has a role in the diagnosis and management of these tumors during pregnancy. In this report, we describe a multidisciplinary approach in a case of a patient with sacrococcygeal teratomas and preterm delivery, as well as postnatal outcomes. Read More

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http://dx.doi.org/10.1186/s13256-020-02395-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304210PMC

Maternal Work and Spontaneous Preterm Birth: A Multicenter Observational Study in Brazil.

Sci Rep 2020 Jun 16;10(1):9684. Epub 2020 Jun 16.

Department of Obstetrics & Gynecology, University of Campinas (Unicamp), School of Medicine, São Paulo, Brazil.

Spontaneous preterm birth (sPTB) is a major pregnancy complication involving biological, social, behavioural and environmental mechanisms. Workload, shift and intensity may play a role in the occurrence of sPTB. This analysis is aimed addressing the effect of occupational activities on the risk for sPTB and the related outcomes. Read More

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http://dx.doi.org/10.1038/s41598-020-66231-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297738PMC

Polyhydramnios and abnormal foetal heart rate patterns in a foetus with Prader-Willi syndrome: A case report.

Case Rep Womens Health 2020 Jul 29;27:e00227. Epub 2020 May 29.

Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Fukushima, Japan.

Introduction: Prader-Willi syndrome (PWS) is a complex neurodevelopmental genetic disorder. No definitive clinical signs of antenatal PWS have been identified.

Case: A healthy, nulliparous, 29-year-old woman demonstrated polyhydramnios at 27 weeks of gestation. Read More

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http://dx.doi.org/10.1016/j.crwh.2020.e00227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283086PMC

A comparison of the risk of cesarean section in gestational diabetes mellitus patients supplemented antenatally with vitamin D containing supplements versus placebo: A systematic review and meta-analysis of double-blinded randomized controlled trials.

J Turk Ger Gynecol Assoc 2020 Jun 10. Epub 2020 Jun 10.

Mankar College, India.

This study aims to study the role of vitamin D containing supplements in the risk of cesarean section (CS), a common complication in gestational diabetes mellitus (GDM) patients. The additional objective was to assess the risk of developing pre-eclampsia, preterm delivery, macrosomia, and polyhydramnios in these participants. Various electronic databases were searched for double-blinded parallel-arm randomized controlled trials that reported the incidence of CS in adult non-insulin treated GDM patients who received vitamin D and placebo in different treatment arms, respectively. Read More

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http://dx.doi.org/10.4274/jtgga.galenos.2020.2019.0164DOI Listing

Outcomes in the giant omphalocele population: A single center comprehensive experience.

J Pediatr Surg 2020 May 3. Epub 2020 May 3.

Cincinnati Children's Hospital Medical Center, Division of Pediatric General and Thoracic Surgery, Cincinnati, OH, USA.

Background/purpose: Morbidity and mortality in the giant omphalocele population is complicated by large abdominal wall defects, physiologic aberrancies, and congenital anomalies. We hypothesized different anomalies and treatment types would affect outcomes.

Methods: A 2009-2018 retrospective chart review of giant omphaloceles was performed. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2020.04.019DOI Listing

Fetal congenital midaortic syndrome with unilateral renal artery stenosis prenatally presenting with polyhydramnios and postpartum as hyponatremic hypertensive syndrome.

BMJ Case Rep 2020 May 21;13(5). Epub 2020 May 21.

Department of Obstetrics and Gynecology, Cantonal Hospital Lucerne, Lucerne, Switzerland.

The midaortic syndrome (MAS) is a rare anomaly, characterised by narrowing of the distal aorta and its major branches. The most common symptom is severe arterial hypertension. The combination of hyponatremia, polyuria and renovascular hypertension caused by a unilateral renal artery stenosis is described as hyponatremic hypertensive syndrome. Read More

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http://dx.doi.org/10.1136/bcr-2020-234459DOI Listing

Pregnancy related pharmacokinetics and antimicrobial prophylaxis during fetal surgery, cefazolin and clindamycin as examples.

Prenat Diagn 2020 May 22. Epub 2020 May 22.

Department of Pharmacy, Erasmus University Medical Center, Rotterdam, The Netherlands.

Antimicrobial prophylaxis during surgery aims to prevent post-operative site infections. For fetal surgery, this includes the fetal and amniotic compartments. Both are deep compartments as drug equilibrium with maternal blood is achieved relatively late. Read More

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http://dx.doi.org/10.1002/pd.5753DOI Listing

Esophageal Atresia: Associated Anomalies, Mortality, and Morbidity in Jordan.

Pediatr Int 2020 May 20. Epub 2020 May 20.

Department of Surgery, Pediatric Surgery Division, School of Medicine, University of Jordan, Amman, Jordan.

Background: Esophageal atresia is a developmental disorder in which the upper and lower esophagus fail to connect. It has an estimated prevalence of 1 in 2500-4500 live births and has poorer outcomes in low- and middle-income countries compared to those in high-income countries. This study focused on the disorder's epidemiology, morbidity and mortality in Jordan in order to address the lack of data regarding esophageal atresia in this country. Read More

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http://dx.doi.org/10.1111/ped.14311DOI Listing

False diagnosis of small for gestational age and macrosomia - clinical and sonographic predictors.

J Matern Fetal Neonatal Med 2020 May 19:1-7. Epub 2020 May 19.

Department of Obstetrics and Gynecology, Hillel Yaffe Medical Center, Hadera, Israel.

To investigate clinical and sonographic features associated with sonographic accuracy for the prediction of small for gestational age (SGA) and macrosomia at birth. The database of a tertiary medical center was retrospectively searched for women who gave birth at term to a singleton healthy neonate in 2007-2014 and underwent sonographic estimated fetal weight (sEFW) evaluation within 3 d before delivery. Fetal growth restriction (FGR) and SGA were defined as sEFW or birth weight <10th percentile for gestational age; macrosomia was defined as birth weight >4000 grams. Read More

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http://dx.doi.org/10.1080/14767058.2020.1762559DOI Listing

Mirror syndrome due to anti-Jra alloimmunization.

Taiwan J Obstet Gynecol 2020 May;59(3):456-459

Department of Obstetrics and Gynecology, Kyorin University School of Medicine, Tokyo, Japan.

Objective: We report a case of fetal hydrops and mirror syndrome in a pregnancy with anti-Jra alloimmunization.

Case Report: A 34-year-old multiparous woman (G3P2) at 29 weeks of gestation had complications which included generalized edema and mild dyspnea. An indirect Coombs test was positive for anti-Jra antibodies. Read More

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http://dx.doi.org/10.1016/j.tjog.2020.03.023DOI Listing

Society for Maternal-Fetal Medicine (SMFM) Consult Series #52: Diagnosis and Management of Fetal Growth Restriction.

Am J Obstet Gynecol 2020 May 12. Epub 2020 May 12.

Fetal growth restriction (FGR) is the final manifestation of a variety of maternal, fetal, and placental conditions. Fetal growth restriction occurs in up to 10% of pregnancies and is second to premature birth as a cause of infant morbidity and mortality. In addition to its significant perinatal impact, FGR also has an impact on long-term health outcomes. Read More

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http://dx.doi.org/10.1016/j.ajog.2020.05.010DOI Listing

Marginal placental cord insertion: the need for follow up?

J Matern Fetal Neonatal Med 2020 May 13:1-7. Epub 2020 May 13.

Department of Obstetrics, Gynecology & Reproductive Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.

The objectives of this study were (1) to estimate the association between marginal placental cord insertion (PCI) and small for gestational age (SGA) and other adverse perinatal outcomes and (2) to determine if pregnancy-associated plasma protein A (PAPP-A) levels was altered in these patients. It was a retrospective cohort study of singleton pregnancies undergoing ultrasound between 2016 and 2018. Marginal PCI was defined as a distance of ≤2 cm from placental edge to PCI site, visualized in both sagittal and transverse planes, and diagnosed between 16 and 32 weeks. Read More

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http://dx.doi.org/10.1080/14767058.2020.1763297DOI Listing

Comparison of criteria of International Association of Diabetes and Pregnancy Study Groups (IADPSG) with National Institute for Health and Care Excellence (NICE) for diagnosis of gestational diabetes mellitus.

Arch Gynecol Obstet 2020 Jul 9;302(1):47-52. Epub 2020 May 9.

Department of Endocrinology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

Background: Different screening procedures and diagnostic criteria are being followed in the same as well as in different countries with no single standard criteria established for diagnosis of GDM. So far, there are no studies in the Indian population comparing IADPSG with NICE criteria.

Objective: To compare International Association of Pregnancy and Study Groups (IADPSG) criteria with the National Institute for Health and Care Excellence (NICE) for diagnosis of gestational diabetes mellitus and its influence on maternal and perinatal outcomes. Read More

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http://dx.doi.org/10.1007/s00404-020-05564-9DOI Listing

Delayed Diagnosis in Esophageal Atresia and Tracheoesophageal Fistula: Case Study.

Adv Neonatal Care 2020 May 6. Epub 2020 May 6.

PIPER (Retrieval Team) (Dr Scott) and Butterfly (Surgical NICU) (Mss Hawley and Brooks), Royal Children's Hospital, Melbourne, Australia.

Background: Timely identification of esophageal atresia is challenging. Diagnosis may be suspected antenatally with a combination of polyhydramnios, associated with a small or absent stomach bubble or other anomalies. Esophageal atresia can be suspected postnatally in the presence of tachypnea, increased oral secretions, and an inability to advance an orogastric tube. Read More

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http://dx.doi.org/10.1097/ANC.0000000000000763DOI Listing

[Etiological diagnosis and clinical evaluation of isolated fetal ascites].

Zhonghua Fu Chan Ke Za Zhi 2020 Apr;55(4):246-252

Department of Obstetrics and Gynecology, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China.

To explore the correlation between prenatal clinical data with etiological diagnosis and neonatal outcome in isolated fetal ascites. Totally, 36 pregnancy cases diagnosed as isolated fetal ascites by ultrasound in Provincial Hospital Affiliated to Shandong University from June 22nd, 2016 to September 28th, 2018 were collected. Invasive prenatal diagnosis was performed by taking fetal cord blood, amniotic fluid, and fetal ascites respectively for cytogenetics, molecular genetics and biochemical examination and the impact of intrauterine therapeutic procedures on neonatal outcomes was evaluated as well. Read More

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http://dx.doi.org/10.3760/cma.j.cn112141-20190605-00312DOI Listing

A giant symptomatic placental chorioangioma managed with a histoacryl injection.

J Ultrasound 2020 May 5. Epub 2020 May 5.

Department of Obstetrics and Gynecology, Chung-Ang University Hospital, College of Medicine, Chung-Ang University, 102, Heukseok-ro, Dongjak-gu, Seoul, 06973, Korea.

Chorioangiomas are generally small and associated with favorable outcomes, but large tumors can cause serious fetal complications, such as polyhydramnios, fetal anemia, intrauterine growth restriction, cardiac failure, fetal hydrops, and intrauterine fetal death. Signs of fetal cardiac failure on ultrasonography are indications for urgent in utero interventions. We report a case of a giant chorioangioma causing fetal cardiac failure at 26 weeks' gestation, which was treated by embolization of the feeding vessels. Read More

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http://dx.doi.org/10.1007/s40477-020-00470-xDOI Listing

Ferulic acid confers protection on islet β cells and placental tissues of rats with gestational diabetes mellitus.

Cell Mol Biol (Noisy-le-grand) 2020 Apr 20;66(1):37-41. Epub 2020 Apr 20.

Department of Gynaecology and Obstetrics, Xi'an NO.4 Hospital, Xi'an, PR China.

Gestational diabetes mellitus (GDM) refers to glucose intolerance of variable degree with onset or first recognition during pregnancy. It causes polyhydramnios, ketoacidosis, fetal macrosomia, and neonatal respiratory distress syndrome. The incidence of GDM has greatly increased, hence the search for new interventions that can effectively treat it. Read More

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The KLHL40 c.1516A>C is a Chinese-specific founder mutation causing nemaline myopathy 8: Report of six patients with pre- and postnatal phenotypes.

Mol Genet Genomic Med 2020 Apr 30:e1229. Epub 2020 Apr 30.

Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China.

Background: Autosomal recessive or compound heterozygous mutations in KLHL40 cause nemaline myopathy 8, which is one of the most severe forms of nemaline myopathy. The KLHL40 c.1516A>C variant has recently been reported as a founder mutation in southern Chinese. Read More

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http://dx.doi.org/10.1002/mgg3.1229DOI Listing

Changes in treatment needs of hypoparathyroidism during pregnancy and lactation: A case series.

Clin Endocrinol (Oxf) 2020 Apr 29. Epub 2020 Apr 29.

Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.

Objective: As only sparse data are available, we aimed to investigate whether needs for activated vitamin D and calcium supplements change in women with hypoparathyroidism during pregnancy and lactation and risk of pregnancy-related complications.

Design: Retrospective review of medical records.

Patients: Twelve Danish and Canadian patients with chronic hypoparathyroidism who completed 17 pregnancies. Read More

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http://dx.doi.org/10.1111/cen.14212DOI Listing

Hydrops fetalis and neonatal abdominal compartment syndrome continuum from immature gastric teratoma: a case report.

BMC Pediatr 2020 Apr 27;20(1):186. Epub 2020 Apr 27.

Philippine General Hospital, Manila, Philippines.

Background: Hydrops fetalis as well as abdominal compartment syndrome (ACS) are conditions that are associated with high mortality rates. A rare case of immature gastric teratoma causing fetal hydrops and subsequent ACS is presented. The related pathophysiologic mechanisms are discussed, and the importance of timely recognition and appropriate interventions are highlighted. Read More

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http://dx.doi.org/10.1186/s12887-020-02090-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184682PMC

Amniotic fluid index curves in the obese gravida.

J Neonatal Perinatal Med 2020 Apr 18. Epub 2020 Apr 18.

Department of Obstetrics and Gynecology, Maternal Fetal Medicine, Augusta University Medical Center at Medical College of Georgia.

Objective: To determine whether amniotic fluid volume as measured by amniotic fluid index (AFI) is influenced by maternal pre-gestational obesity as measured by body mass index (BMI).

Methods: This was a retrospective cohort study of pregnant women between 20 and 43 weeks gestation receiving ultrasounds with AFI measurements at Augusta University Medical Center between 2003 and 2017. A subset of 500 charts that met inclusion and exclusion criteria were reviewed to obtain maternal clinical data. Read More

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http://dx.doi.org/10.3233/NPM-190290DOI Listing

Mutations and Their Clinical Presentations: New Case Report and Systematic Review.

Case Rep Med 2020 13;2020:8795607. Epub 2020 Apr 13.

School of Medicine, Lebanese University, Beirut, Lebanon.

Lethal congenital contracture syndrome type 7 (LCCS7) and congenital hypomyelinating neuropathy type 3 (CHN3) are rare autosomal recessive diseases, characterized by severe neonatal hypotonia, polyhydramnios, arthrogryposis, facial diplegia, and severe motor paralysis, leading to death in early infancy. They are related to mutations in the (contactin associated protein 1) gene, playing an important role in myelination. Recent studies have shown that both diseases could present with a wide phenotypic spectrum, with promising survival up to early childhood. Read More

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http://dx.doi.org/10.1155/2020/8795607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174947PMC

Esophageal atresia and tracheoesophageal fistula: prenatal sonographic Manifestation from early to late pregnancy.

Ultrasound Obstet Gynecol 2020 Apr 18. Epub 2020 Apr 18.

Departments of Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Objective: Esophageal atresia with or without trachea-esophageal fistula (EA/TEF) remains one of the most prenatally missed congenital anomalies. The aim of our study was to elucidate sonographic manifestation of EA/TEF throughout pregnancy.

Methods: A retrospective study of 12 years was performed at a tertiary center. Read More

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http://dx.doi.org/10.1002/uog.22050DOI Listing

Recognizing the unique prenatal phenotype of Prader-Willi Syndrome (PWS) indicates the need for a diagnostic methylation test.

Prenat Diagn 2020 Jun 21;40(7):878-884. Epub 2020 May 21.

Hebrew University of Jerusalem Faculty of Medicine, Jerusalem, Israel.

Objectives: Prader-Willi syndrome (PWS) is a neurogenetic disorder characterized by mental retardation, morbid obesity, and endocrine and behavior disorders. We previously showed in a small group of patients that PWS may have a unique prenatal phenotype. We aimed to characterize clinical and ultrasonic features in a larger series of pregnancies with a PWS fetus. Read More

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http://dx.doi.org/10.1002/pd.5712DOI Listing

A two-year follow-up of asfotase alfa replacement in a patient with hypophosphatasia: clinical, biochemical, and radiological evaluation.

Arch Endocrinol Metab 2020 Apr 6. Epub 2020 Apr 6.

Departamento de Medicina, Disciplina de Endocrinologia, Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brasil.

Hypophosphatasia (HPP) is a rare disease with a high mortality rate in its severe forms. It is caused by mutations within the gene encoding the tissue-nonspecific alkaline phosphatase (TNSALP), an enzyme responsible for bone mineralization. In 2015, the Food and Drug Administration approved the use of asfotase alfa, the first medication showing benefit in the treatment of HPP. Read More

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http://dx.doi.org/10.20945/2359-3997000000222DOI Listing

Effectiveness of telemedicine for pregnant women with gestational diabetes mellitus: an updated meta-analysis of 32 randomized controlled trials with trial sequential analysis.

BMC Pregnancy Childbirth 2020 Apr 6;20(1):198. Epub 2020 Apr 6.

Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, China.

Background: Gestational diabetes mellitus (GDM) is now a global health problem. Poor blood glucose control during pregnancy may lead to maternal and neonatal/foetal complications. Recently, the development of information and communication technology has resulted in new technical support for the clinical care of GDM. Read More

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http://dx.doi.org/10.1186/s12884-020-02892-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137255PMC

Impact of Perinatal Primary Hyperparathyroidism on Maternal and Fetal and Neonatal Outcomes: Retrospective Case Series.

J Obstet Gynaecol Can 2020 Jun 29;42(6):750-756. Epub 2020 Mar 29.

Department of Obstetrics and Gynecology, Maternal Fetal Medicine Division, Mount Sinai Hospital, Toronto, ON; Department of Medicine, University of Toronto, Toronto, ON; Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON.

Objective: We sought to describe the maternal, fetal, and neonatal outcomes of primary hyperparathyroidism in a contemporary setting through a retrospective case series conducted in a tertiary referral centre focused on women diagnosed with primary hyperparathyroidism prior to conception, in the antepartum period, or within 6 weeks postpartum.

Methods: A retrospective chart review was conducted and data were abstracted to case report forms. Summary statistics are reported. Read More

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http://dx.doi.org/10.1016/j.jogc.2019.12.017DOI Listing

SLC26A3 mutation in Turkish neonate and her sibling with congenital chloride diarrhea.

Turk Pediatri Ars 2020 9;55(1):76-78. Epub 2020 Mar 9.

Department of Child Health and Diseases, Karabük University Faculty of Medicine, Karabük, Turkey.

Congenital chloride diarrhea is a rare cause of severe infantile diarrhea with excessive chloride excretion. Mutations in the SLC26A3 gene cause congenital chloride diarrhea. It generally becomes apparent in the neonatal period and is characterized by electrolyte imbalances, metabolic alkalosis, and failure to thrive. Read More

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http://dx.doi.org/10.5152/TurkPediatriArs.2018.6929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096564PMC

Prenatal and perinatal risk and protective factors for psychosis: a systematic review and meta-analysis.

Lancet Psychiatry 2020 05 24;7(5):399-410. Epub 2020 Mar 24.

Early Psychosis: Interventions and Clinical-detection (EPIC) Laboratory, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; National Institute for Health Research Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, London, UK; Outreach And Support in South London (OASIS) Service, South London and Maudsley NHS Foundation Trust, London, UK; Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy. Electronic address:

Background: Prenatal and perinatal insults are implicated in the aetiopathogenesis of psychotic disorders but the consistency and magnitude of their associations with psychosis have not been updated for nearly two decades. The aim of this systematic review and meta-analysis was to provide a comprehensive and up-to-date synthesis of the evidence on the association between prenatal or perinatal risk and protective factors and psychotic disorders.

Methods: In this systematic review and meta-analysis, we searched the Web of Science database for articles published up to July 20, 2019. Read More

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http://dx.doi.org/10.1016/S2215-0366(20)30057-2DOI Listing

Non-immune fetal hydrops: etiology and outcomes according to gestational age at diagnosis.

Ultrasound Obstet Gynecol 2020 Mar 20. Epub 2020 Mar 20.

Fetal Medicine Unit, St George's Hospital, St George's University of London, UK.

Objectives: Fetal hydrops is associated with increased perinatal mortality and morbidity. The etiology and outcomes of fetal hydrops may differ according to the gestational age (GA) at diagnosis. The aim of this study was to evaluate the causes, evolution and outcomes of non-immune fetal hydrops (NIFH) according to the GA at diagnosis. Read More

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http://dx.doi.org/10.1002/uog.22019DOI Listing

Myasthaenia gravis in pregnancy, delivery and newborn.

Minerva Ginecol 2020 Feb;72(1):30-35

Department of Obstetrics and Gynecology, Sapienza University, Rome, Italy.

Introduction: Myasthaenia gravis (MG) is the most common disease of the neuromuscular junction; clinical presentation of the disease includes a variety of symptoms, the most frequent beign the only ocular muscles involvement, to the generalized myasthenic crisis with diaphragmatic impairment and respiratory insufficiency. It is most common in women between 20 ad 40 years.

Evidence Acquisition: We performed a comprehensive search of relevant studies from January1990 to Dicember 2019 to ensure all possible studies were captured. Read More

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http://dx.doi.org/10.23736/S0026-4784.20.04505-0DOI Listing
February 2020

Adverse perinatal outcomes in 665,244 term and post-term deliveries-a Norwegian population-based study.

Eur J Obstet Gynecol Reprod Biol 2020 Apr 17;247:212-218. Epub 2020 Feb 17.

Department of Obstetrics, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Norway.

Objective: To assess the prevalence and risk of adverse perinatal outcomes in early-term (37-38 weeks), full-term (39-40 weeks), late-term (41-41 weeks), and post-term (>42 weeks) deliveries with spontaneous labor onset.

Study Design: A population-based cohort with data from the Medical Birth Registry Norway (MBRN) and Statistics Norway (SSB) was conducted. The study population consisted of 665,244 women with cephalic singleton live births at term or post-term with spontaneous labor onset during the period of 1999-2014 in Norway. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2020.02.028DOI Listing

Development of a prenatal clinical care pathway for uncomplicated gastroschisis and literature review.

J Neonatal Perinatal Med 2020 Mar 5. Epub 2020 Mar 5.

Department of Obstetrics/Gynecology, Division of Maternal-Fetal Medicine, University of Washington Medical Center, Seattle, WA, USA.

Background: Gastroschisis is an abdominal wall defect wherein the bowel is herniated into the amniotic fluid. Controversy exists regarding optimal prenatal surveillance strategies that predict fetal well-being and help guide timing of delivery. Our objective was to develop a clinical care pathway for prenatal management of uncomplicated gastroschisis at our institution. Read More

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http://dx.doi.org/10.3233/NPM-190277DOI Listing

"INTERGROWTH21st vs customized fetal growth curves in the assessment of the neonatal nutritional status: a retrospective cohort study of gestational diabetes".

BMC Pregnancy Childbirth 2020 Mar 4;20(1):139. Epub 2020 Mar 4.

Maternity Unit, Valme University Hospital, Seville, Spain.

Background: Gestational diabetes mellitus is associated with increased incidence of adverse perinatal outcomes including newborns large for gestational age, macrosomia, preeclampsia, polyhydramnios, stillbirth, and neonatal morbidity. Thus, fetal growth should be monitored by ultrasound to assess for fetal overnutrition, and thereby, its clinical consequence, macrosomia. However, it is not clear which reference curve to use to define the limits of normality. Read More

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http://dx.doi.org/10.1186/s12884-020-2845-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057488PMC

Perinatal outcomes in pregnancies complicated by type 1 diabetes mellitus.

Gynecol Endocrinol 2020 Feb 19:1-6. Epub 2020 Feb 19.

Department of Endocrinology, Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.

The aim of this study was to explore the risk of perinatal outcomes in pre-gestational type 1 diabetes mellitus (T1DM) compared to gestational diabetes mellitus (GDM) and pregnancy without diabetes and to examine the association of glycemic level of third-trimester gestation with perinatal outcomes in T1DM. We included 69 pre-gestational T1DM, 1398 cases of GDM, and 1304 control pregnancies and collected data regarding demographics, obstetric, and perinatal outcomes from the hospital discharge database. Relative to the pregnancies without diabetes, women with T1DM encountered increasing risk of polyhydramnios, preterm delivery, and cesarean section. Read More

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http://dx.doi.org/10.1080/09513590.2020.1727432DOI Listing
February 2020
1.136 Impact Factor

Effect of pregravid obesity on perinatal outcomes in singleton pregnancies following in vitro fertilization and the weight-loss goals to reduce the risks of poor pregnancy outcomes: A retrospective cohort study.

PLoS One 2020 13;15(2):e0227766. Epub 2020 Feb 13.

Reproductive Hospital Affiliated to Shandong University, Jinan, China.

Objective: In the present study, we aimed to determine whether pregravid obesity independently predicts increased risks of perinatal complications following in vitro fertilization (IVF) and the weight loss goals to reduce the risk of poor pregnancy outcomes.

Design: Retrospective cohort study.

Population: All pregnancies after first the fresh IVF cycle from January 2014 to December 2016 in the Reproductive Center affiliated to Shandong University were reviewed. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0227766PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7027660PMC

Single-Center Outcome of Fetoscopic Tracheal Balloon Occlusion for Severe Congenital Diaphragmatic Hernia.

Obstet Gynecol 2020 Mar;135(3):511-521

Center for Fetal Therapy, Department of Gynecology & Obstetrics, the Department of Anesthesiology and Critical Care Medicine, the Division of Maternal-Fetal Medicine, Department of Gynecology & Obstetrics, the Division of Neonatology and the Pediatric Intensive Care Unit, Department of Pediatrics, and the Division of Pediatric Surgery, Department of Surgery, Johns Hopkins University School Medicine, Baltimore, Maryland.

Objective: To assess feasibility and maternal and infant outcome after fetoscopic tracheal balloon occlusion in patients with severe congenital diaphragmatic hernia.

Methods: We conducted a prospective cohort study of fetuses with congenital diaphragmatic hernia and observed/expected lung/head ratio less than 30%. Eligible women had planned fetoscopic tracheal balloon occlusion at 26 0/7-29 6/7 weeks of gestation and balloon removal 4-6 weeks later. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003692DOI Listing

A case of amniotic fluid embolism successfully treated by multidisciplinary treatment.

JA Clin Rep 2019 Nov 28;5(1):79. Epub 2019 Nov 28.

Department of Anesthesiology and Intensive Care, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.

Background: Amniotic fluid embolism (AFE) is a life-threatening obstetric emergency. Because the maternal mortality associated with AFE is very high, early recognition and prompt treatment are important for improving the prognosis. We report a case of amniotic fluid embolism successfully treated by multidisciplinary treatment. Read More

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http://dx.doi.org/10.1186/s40981-019-0296-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6967009PMC
November 2019

Non-invasive fetal electrocardiography ameliorates fetal outcome in chorioangioma: A case report.

Authors:
I V Lakhno

J Neonatal Perinatal Med 2020 Jan 27. Epub 2020 Jan 27.

Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine.

 Chorioangioma is a rare vascular placental tumour. Large chorioangiomas are known to have many maternal and perinatal complications. The case of placental chorioangioma detected via ultrasound is presented. Read More

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http://dx.doi.org/10.3233/NPM-190329DOI Listing
January 2020

Reproductive health issues in female patients with beta-thalassaemia major: a narrative literature review.

J Obstet Gynaecol 2020 Jan 30:1-10. Epub 2020 Jan 30.

Department of Midwifery and Reproductive Health, Nursing and Midwifery School, Tehran University of Medical Sciences, Tehran, Iran.

β-thalassaemia major (BTM) has a high prevalence worldwide and is associated with considerable morbidity and mortality. The aim of this review is to provide an illustrative overview of the reproductive health and pregnancy related issues in females with β-thalassaemia. A literature search was performed in four international databases (1980-2018) to identify the potentially relevant articles. Read More

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http://dx.doi.org/10.1080/01443615.2019.1692802DOI Listing
January 2020

Kagami-Ogata syndrome: an important differential diagnosis to Beckwith-Wiedemann syndrome.

J Clin Ultrasound 2020 May 28;48(4):240-243. Epub 2020 Jan 28.

Klinik für Geburtsmedizin, Charité - Universitätsmedizin, Berlin, Germany.

We report the case of a fetus with sonographic characteristics of Beckwith-Wiedemann syndrome (BWS). A 30-year-old gravida 2 para 1 was referred to our fetal medicine unit with an omphalocele. Fetal macrosomia, organomegaly, and polyhydramnios but no macroglossia were detected and BWS was suspected. Read More

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http://dx.doi.org/10.1002/jcu.22815DOI Listing

Perinatal features of Prader-Willi syndrome: a Chinese cohort of 134 patients.

Orphanet J Rare Dis 2020 Jan 21;15(1):24. Epub 2020 Jan 21.

Department of Endocrinology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, 3333 Binsheng Rd, Hangzhou 310052, China.

Background: Prader-Willi syndrome (PWS) is a rare and complex genetic disorder caused by lacking expression of imprinted genes on the paternally derived chromosome 15q11-q13 region. This study aimed to characterize the perinatal features of 134 Chinese individuals with PWS.

Methods: This study included the patients of a PWS registry in China. Read More

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http://dx.doi.org/10.1186/s13023-020-1306-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6975078PMC
January 2020