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Nephrol Ther 2020 Jul 1. Epub 2020 Jul 1.

Département de génétique, hôpital européen Georges-Pompidou, 20, rue Leblanc, 75015 Paris, France; Centre de Référence de maladies rénales rares de l'enfant et de l'adulte (MARHEA), Paris, France.

Bartter-Gitelman syndromes are rare inherited autosomal recessive salt-losing tubulopathies characterized by severe and chronic hypokalemia associated with metabolic alkalosis and secondary hyperaldosteronism. Bartter syndrome results from a furosemide-like defect in sodium reabsorption in the Henle's loop leading to hypercalciuria and defect in urinary concentration capacity. The antenatal Bartter syndrome is defined by polyhydramnios and an infantile polyuria with severe dehydration whereas classic Bartter syndrome appears during childhood or adulthood. Read More

Am J Med Genet A 2020 Jul 2. Epub 2020 Jul 2.

Department of Clinical Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

The etiology of nonimmune hydrops fetalis is extensive and includes genetic disorders. We describe a term-born female neonate with late onset extensive nonimmune hydrops, that is, polyhydramnios, edema, and congenital bilateral chylothorax. This newborn was successfully treated with repetitive thoracocentesis, total parenteral feeding, octreotide intravenously and finally surgical pleurodesis and corticosteroids. Read More

Arch Gynecol Obstet 2020 Jun 29. Epub 2020 Jun 29.

Department of Obstetrics and Gynecology, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, POB 151, 84101, Beer-Sheva, Israel.

Background: Amniotic fluid abnormalities may be associated with adverse perinatal outcomes, some of which are endocrine related.

Objective: To evaluate whether in utero exposure to amniotic fluid abnormalities is associated with long-term endocrine morbidity in the offspring.

Study Design: In this cohort study, the incidence of long-term endocrine disorders was compared between singletons exposed and non-exposed to oligohydramnios or polyhydramnios. Read More

BMC Pediatr 2020 Jun 26;20(1):311. Epub 2020 Jun 26.

Department of Pediatrics, Schulich School of Medicine and Dentistry, University of Western Ontario, 1151 Richmond Street, London, ON, N6A5C1, Canada.

Background: Bartter syndrome subtypes are a group of rare renal tubular diseases characterized by impaired salt reabsorption in the tubule, specifically the thick ascending limb of Henle's loop. Clinically, they are characterized by the association of hypokalemic metabolic alkalosis, hypercalciuria, nephrocalcinosis, increased levels of plasma renin and aldosterone, low blood pressure and vascular resistance to angiotensin II. Bartter syndrome type II is caused by mutations in the renal outer medullary potassium channel (ROMK) gene (KCNJ1), can present in the newborn period and typically requires lifelong therapy. Read More

Z Geburtshilfe Neonatol 2020 Jun 26. Epub 2020 Jun 26.

Perinatology, Department of Obstetrics and Gynecology, Division of Perinatology, Sanliurfa Training and Research Hospital, Sanlıurfa, Turkey.

Introduction: Uterocervical angle measurements in pregnant women with idiopathic polyhydramnios were appraised for their predictive value for spontaneous preterm labor.

Material And Methods: In this prospective study, we included nulliparous and multiparous pregnant women diagnosed with idiopathic polyhydramnios at 24-28 weeks at our polyclinic; the uterocervical angle and cervical length were measured by transvaginal ultrasound at the time of diagnosis. Routine pregnancy follow-up was done by our team and gestational age at delivery and maternal-fetal outcomes were noted. Read More

Eur J Endocrinol 2020 Aug;183(2):R29-R40

For an endocrinologist, nephrogenic diabetes insipidus (NDI) is an end-organ disease, that is the antidiuretic hormone, arginine-vasopressin (AVP) is normally produced but not recognized by the kidney with an inability to concentrate urine despite elevated plasma concentrations of AVP. Polyuria with hyposthenuria and polydipsia are the cardinal clinical manifestations of the disease. For a geneticist, hereditary NDI is a rare disease with a prevalence of five per million males secondary to loss of function of the vasopressin V2 receptor, an X-linked gene, or loss of function of the water channel AQP2. Read More

Pol Merkur Lekarski 2020 Jun;48(285):157-161

I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine.

Social trends, a new style of modern young woman, which includes the polygamy of sexual relationships, increases the incidence and probability of infection caused by sexually transmitted pathogens, including the human papillomavirus. In women entered into motherhood with chronic papillomavirus carrier, pregnancy is accompanied with an increase in obstetrics and perinatal complications. The inability to use antiviral therapy due to its embryo- and fetotoxic effects requires searching for safe agents for timely and effective preconceptional and prenatal preparation for the fetal infection prevention. Read More

J Med Case Rep 2020 Jun 19;14(1):72. Epub 2020 Jun 19.

Gynecology and Obstetrics Department, Corporació Sanitària Parc Taulí, Parc Taulí s/n, 08208, Sabadell, Spain.

Background: Sacrococcygeal teratoma is one of the most frequently prenatally diagnosed neoplasias. Obstetric ultrasound has a role in the diagnosis and management of these tumors during pregnancy. In this report, we describe a multidisciplinary approach in a case of a patient with sacrococcygeal teratomas and preterm delivery, as well as postnatal outcomes. Read More

Sci Rep 2020 Jun 16;10(1):9684. Epub 2020 Jun 16.

Department of Obstetrics & Gynecology, University of Campinas (Unicamp), School of Medicine, São Paulo, Brazil.

Spontaneous preterm birth (sPTB) is a major pregnancy complication involving biological, social, behavioural and environmental mechanisms. Workload, shift and intensity may play a role in the occurrence of sPTB. This analysis is aimed addressing the effect of occupational activities on the risk for sPTB and the related outcomes. Read More

Case Rep Womens Health 2020 Jul 29;27:e00227. Epub 2020 May 29.

Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Fukushima, Japan.

Introduction: Prader-Willi syndrome (PWS) is a complex neurodevelopmental genetic disorder. No definitive clinical signs of antenatal PWS have been identified.

Case: A healthy, nulliparous, 29-year-old woman demonstrated polyhydramnios at 27 weeks of gestation. Read More

J Turk Ger Gynecol Assoc 2020 Jun 10. Epub 2020 Jun 10.

Mankar College, India.

This study aims to study the role of vitamin D containing supplements in the risk of cesarean section (CS), a common complication in gestational diabetes mellitus (GDM) patients. The additional objective was to assess the risk of developing pre-eclampsia, preterm delivery, macrosomia, and polyhydramnios in these participants. Various electronic databases were searched for double-blinded parallel-arm randomized controlled trials that reported the incidence of CS in adult non-insulin treated GDM patients who received vitamin D and placebo in different treatment arms, respectively. Read More

J Pediatr Surg 2020 May 3. Epub 2020 May 3.

Cincinnati Children's Hospital Medical Center, Division of Pediatric General and Thoracic Surgery, Cincinnati, OH, USA.

Background/purpose: Morbidity and mortality in the giant omphalocele population is complicated by large abdominal wall defects, physiologic aberrancies, and congenital anomalies. We hypothesized different anomalies and treatment types would affect outcomes.

Methods: A 2009-2018 retrospective chart review of giant omphaloceles was performed. Read More

BMJ Case Rep 2020 May 21;13(5). Epub 2020 May 21.

Department of Obstetrics and Gynecology, Cantonal Hospital Lucerne, Lucerne, Switzerland.

The midaortic syndrome (MAS) is a rare anomaly, characterised by narrowing of the distal aorta and its major branches. The most common symptom is severe arterial hypertension. The combination of hyponatremia, polyuria and renovascular hypertension caused by a unilateral renal artery stenosis is described as hyponatremic hypertensive syndrome. Read More

Prenat Diagn 2020 May 22. Epub 2020 May 22.

Department of Pharmacy, Erasmus University Medical Center, Rotterdam, The Netherlands.

Antimicrobial prophylaxis during surgery aims to prevent post-operative site infections. For fetal surgery, this includes the fetal and amniotic compartments. Both are deep compartments as drug equilibrium with maternal blood is achieved relatively late. Read More

Pediatr Int 2020 May 20. Epub 2020 May 20.

Department of Surgery, Pediatric Surgery Division, School of Medicine, University of Jordan, Amman, Jordan.

Background: Esophageal atresia is a developmental disorder in which the upper and lower esophagus fail to connect. It has an estimated prevalence of 1 in 2500-4500 live births and has poorer outcomes in low- and middle-income countries compared to those in high-income countries. This study focused on the disorder's epidemiology, morbidity and mortality in Jordan in order to address the lack of data regarding esophageal atresia in this country. Read More

J Matern Fetal Neonatal Med 2020 May 19:1-7. Epub 2020 May 19.

Department of Obstetrics and Gynecology, Hillel Yaffe Medical Center, Hadera, Israel.

To investigate clinical and sonographic features associated with sonographic accuracy for the prediction of small for gestational age (SGA) and macrosomia at birth. The database of a tertiary medical center was retrospectively searched for women who gave birth at term to a singleton healthy neonate in 2007-2014 and underwent sonographic estimated fetal weight (sEFW) evaluation within 3 d before delivery. Fetal growth restriction (FGR) and SGA were defined as sEFW or birth weight <10th percentile for gestational age; macrosomia was defined as birth weight >4000 grams. Read More

Taiwan J Obstet Gynecol 2020 May;59(3):456-459

Department of Obstetrics and Gynecology, Kyorin University School of Medicine, Tokyo, Japan.

Objective: We report a case of fetal hydrops and mirror syndrome in a pregnancy with anti-Jra alloimmunization.

Case Report: A 34-year-old multiparous woman (G3P2) at 29 weeks of gestation had complications which included generalized edema and mild dyspnea. An indirect Coombs test was positive for anti-Jra antibodies. Read More

Am J Obstet Gynecol 2020 May 12. Epub 2020 May 12.

Fetal growth restriction (FGR) is the final manifestation of a variety of maternal, fetal, and placental conditions. Fetal growth restriction occurs in up to 10% of pregnancies and is second to premature birth as a cause of infant morbidity and mortality. In addition to its significant perinatal impact, FGR also has an impact on long-term health outcomes. Read More

J Matern Fetal Neonatal Med 2020 May 13:1-7. Epub 2020 May 13.

Department of Obstetrics, Gynecology & Reproductive Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.

The objectives of this study were (1) to estimate the association between marginal placental cord insertion (PCI) and small for gestational age (SGA) and other adverse perinatal outcomes and (2) to determine if pregnancy-associated plasma protein A (PAPP-A) levels was altered in these patients. It was a retrospective cohort study of singleton pregnancies undergoing ultrasound between 2016 and 2018. Marginal PCI was defined as a distance of ≤2 cm from placental edge to PCI site, visualized in both sagittal and transverse planes, and diagnosed between 16 and 32 weeks. Read More

Arch Gynecol Obstet 2020 Jul 9;302(1):47-52. Epub 2020 May 9.

Department of Endocrinology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

Background: Different screening procedures and diagnostic criteria are being followed in the same as well as in different countries with no single standard criteria established for diagnosis of GDM. So far, there are no studies in the Indian population comparing IADPSG with NICE criteria.

Objective: To compare International Association of Pregnancy and Study Groups (IADPSG) criteria with the National Institute for Health and Care Excellence (NICE) for diagnosis of gestational diabetes mellitus and its influence on maternal and perinatal outcomes. Read More

Adv Neonatal Care 2020 May 6. Epub 2020 May 6.

PIPER (Retrieval Team) (Dr Scott) and Butterfly (Surgical NICU) (Mss Hawley and Brooks), Royal Children's Hospital, Melbourne, Australia.

Background: Timely identification of esophageal atresia is challenging. Diagnosis may be suspected antenatally with a combination of polyhydramnios, associated with a small or absent stomach bubble or other anomalies. Esophageal atresia can be suspected postnatally in the presence of tachypnea, increased oral secretions, and an inability to advance an orogastric tube. Read More

Zhonghua Fu Chan Ke Za Zhi 2020 Apr;55(4):246-252

Department of Obstetrics and Gynecology, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China.

To explore the correlation between prenatal clinical data with etiological diagnosis and neonatal outcome in isolated fetal ascites. Totally, 36 pregnancy cases diagnosed as isolated fetal ascites by ultrasound in Provincial Hospital Affiliated to Shandong University from June 22nd, 2016 to September 28th, 2018 were collected. Invasive prenatal diagnosis was performed by taking fetal cord blood, amniotic fluid, and fetal ascites respectively for cytogenetics, molecular genetics and biochemical examination and the impact of intrauterine therapeutic procedures on neonatal outcomes was evaluated as well. Read More

J Ultrasound 2020 May 5. Epub 2020 May 5.

Department of Obstetrics and Gynecology, Chung-Ang University Hospital, College of Medicine, Chung-Ang University, 102, Heukseok-ro, Dongjak-gu, Seoul, 06973, Korea.

Chorioangiomas are generally small and associated with favorable outcomes, but large tumors can cause serious fetal complications, such as polyhydramnios, fetal anemia, intrauterine growth restriction, cardiac failure, fetal hydrops, and intrauterine fetal death. Signs of fetal cardiac failure on ultrasonography are indications for urgent in utero interventions. We report a case of a giant chorioangioma causing fetal cardiac failure at 26 weeks' gestation, which was treated by embolization of the feeding vessels. Read More

Cell Mol Biol (Noisy-le-grand) 2020 Apr 20;66(1):37-41. Epub 2020 Apr 20.

Department of Gynaecology and Obstetrics, Xi'an NO.4 Hospital, Xi'an, PR China.

Gestational diabetes mellitus (GDM) refers to glucose intolerance of variable degree with onset or first recognition during pregnancy. It causes polyhydramnios, ketoacidosis, fetal macrosomia, and neonatal respiratory distress syndrome. The incidence of GDM has greatly increased, hence the search for new interventions that can effectively treat it. Read More

Mol Genet Genomic Med 2020 Apr 30:e1229. Epub 2020 Apr 30.

Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China.

Background: Autosomal recessive or compound heterozygous mutations in KLHL40 cause nemaline myopathy 8, which is one of the most severe forms of nemaline myopathy. The KLHL40 c.1516A>C variant has recently been reported as a founder mutation in southern Chinese. Read More

Clin Endocrinol (Oxf) 2020 Apr 29. Epub 2020 Apr 29.

Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.

Objective: As only sparse data are available, we aimed to investigate whether needs for activated vitamin D and calcium supplements change in women with hypoparathyroidism during pregnancy and lactation and risk of pregnancy-related complications.

Design: Retrospective review of medical records.

Patients: Twelve Danish and Canadian patients with chronic hypoparathyroidism who completed 17 pregnancies. Read More

BMC Pediatr 2020 Apr 27;20(1):186. Epub 2020 Apr 27.

Philippine General Hospital, Manila, Philippines.

Background: Hydrops fetalis as well as abdominal compartment syndrome (ACS) are conditions that are associated with high mortality rates. A rare case of immature gastric teratoma causing fetal hydrops and subsequent ACS is presented. The related pathophysiologic mechanisms are discussed, and the importance of timely recognition and appropriate interventions are highlighted. Read More

J Neonatal Perinatal Med 2020 Apr 18. Epub 2020 Apr 18.

Department of Obstetrics and Gynecology, Maternal Fetal Medicine, Augusta University Medical Center at Medical College of Georgia.

Objective: To determine whether amniotic fluid volume as measured by amniotic fluid index (AFI) is influenced by maternal pre-gestational obesity as measured by body mass index (BMI).

Methods: This was a retrospective cohort study of pregnant women between 20 and 43 weeks gestation receiving ultrasounds with AFI measurements at Augusta University Medical Center between 2003 and 2017. A subset of 500 charts that met inclusion and exclusion criteria were reviewed to obtain maternal clinical data. Read More

Case Rep Med 2020 13;2020:8795607. Epub 2020 Apr 13.

School of Medicine, Lebanese University, Beirut, Lebanon.

Lethal congenital contracture syndrome type 7 (LCCS7) and congenital hypomyelinating neuropathy type 3 (CHN3) are rare autosomal recessive diseases, characterized by severe neonatal hypotonia, polyhydramnios, arthrogryposis, facial diplegia, and severe motor paralysis, leading to death in early infancy. They are related to mutations in the (contactin associated protein 1) gene, playing an important role in myelination. Recent studies have shown that both diseases could present with a wide phenotypic spectrum, with promising survival up to early childhood. Read More

Ultrasound Obstet Gynecol 2020 Apr 18. Epub 2020 Apr 18.

Departments of Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Objective: Esophageal atresia with or without trachea-esophageal fistula (EA/TEF) remains one of the most prenatally missed congenital anomalies. The aim of our study was to elucidate sonographic manifestation of EA/TEF throughout pregnancy.

Methods: A retrospective study of 12 years was performed at a tertiary center. Read More

Prenat Diagn 2020 Jun 21;40(7):878-884. Epub 2020 May 21.

Hebrew University of Jerusalem Faculty of Medicine, Jerusalem, Israel.

Objectives: Prader-Willi syndrome (PWS) is a neurogenetic disorder characterized by mental retardation, morbid obesity, and endocrine and behavior disorders. We previously showed in a small group of patients that PWS may have a unique prenatal phenotype. We aimed to characterize clinical and ultrasonic features in a larger series of pregnancies with a PWS fetus. Read More

Arch Endocrinol Metab 2020 Apr 6. Epub 2020 Apr 6.

Departamento de Medicina, Disciplina de Endocrinologia, Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brasil.

Hypophosphatasia (HPP) is a rare disease with a high mortality rate in its severe forms. It is caused by mutations within the gene encoding the tissue-nonspecific alkaline phosphatase (TNSALP), an enzyme responsible for bone mineralization. In 2015, the Food and Drug Administration approved the use of asfotase alfa, the first medication showing benefit in the treatment of HPP. Read More

BMC Pregnancy Childbirth 2020 Apr 6;20(1):198. Epub 2020 Apr 6.

Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, China.

Background: Gestational diabetes mellitus (GDM) is now a global health problem. Poor blood glucose control during pregnancy may lead to maternal and neonatal/foetal complications. Recently, the development of information and communication technology has resulted in new technical support for the clinical care of GDM. Read More

J Obstet Gynaecol Can 2020 Jun 29;42(6):750-756. Epub 2020 Mar 29.

Department of Obstetrics and Gynecology, Maternal Fetal Medicine Division, Mount Sinai Hospital, Toronto, ON; Department of Medicine, University of Toronto, Toronto, ON; Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON.

Objective: We sought to describe the maternal, fetal, and neonatal outcomes of primary hyperparathyroidism in a contemporary setting through a retrospective case series conducted in a tertiary referral centre focused on women diagnosed with primary hyperparathyroidism prior to conception, in the antepartum period, or within 6 weeks postpartum.

Methods: A retrospective chart review was conducted and data were abstracted to case report forms. Summary statistics are reported. Read More

Turk Pediatri Ars 2020 9;55(1):76-78. Epub 2020 Mar 9.

Department of Child Health and Diseases, Karabük University Faculty of Medicine, Karabük, Turkey.

Congenital chloride diarrhea is a rare cause of severe infantile diarrhea with excessive chloride excretion. Mutations in the SLC26A3 gene cause congenital chloride diarrhea. It generally becomes apparent in the neonatal period and is characterized by electrolyte imbalances, metabolic alkalosis, and failure to thrive. Read More

Lancet Psychiatry 2020 05 24;7(5):399-410. Epub 2020 Mar 24.

Early Psychosis: Interventions and Clinical-detection (EPIC) Laboratory, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; National Institute for Health Research Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, London, UK; Outreach And Support in South London (OASIS) Service, South London and Maudsley NHS Foundation Trust, London, UK; Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy. Electronic address:

Background: Prenatal and perinatal insults are implicated in the aetiopathogenesis of psychotic disorders but the consistency and magnitude of their associations with psychosis have not been updated for nearly two decades. The aim of this systematic review and meta-analysis was to provide a comprehensive and up-to-date synthesis of the evidence on the association between prenatal or perinatal risk and protective factors and psychotic disorders.

Methods: In this systematic review and meta-analysis, we searched the Web of Science database for articles published up to July 20, 2019. Read More

Ultrasound Obstet Gynecol 2020 Mar 20. Epub 2020 Mar 20.

Fetal Medicine Unit, St George's Hospital, St George's University of London, UK.

Objectives: Fetal hydrops is associated with increased perinatal mortality and morbidity. The etiology and outcomes of fetal hydrops may differ according to the gestational age (GA) at diagnosis. The aim of this study was to evaluate the causes, evolution and outcomes of non-immune fetal hydrops (NIFH) according to the GA at diagnosis. Read More

Minerva Ginecol 2020 Feb;72(1):30-35

Department of Obstetrics and Gynecology, Sapienza University, Rome, Italy.

Introduction: Myasthaenia gravis (MG) is the most common disease of the neuromuscular junction; clinical presentation of the disease includes a variety of symptoms, the most frequent beign the only ocular muscles involvement, to the generalized myasthenic crisis with diaphragmatic impairment and respiratory insufficiency. It is most common in women between 20 ad 40 years.

Evidence Acquisition: We performed a comprehensive search of relevant studies from January1990 to Dicember 2019 to ensure all possible studies were captured. Read More

Eur J Obstet Gynecol Reprod Biol 2020 Apr 17;247:212-218. Epub 2020 Feb 17.

Department of Obstetrics, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Norway.

Objective: To assess the prevalence and risk of adverse perinatal outcomes in early-term (37-38 weeks), full-term (39-40 weeks), late-term (41-41 weeks), and post-term (>42 weeks) deliveries with spontaneous labor onset.

Study Design: A population-based cohort with data from the Medical Birth Registry Norway (MBRN) and Statistics Norway (SSB) was conducted. The study population consisted of 665,244 women with cephalic singleton live births at term or post-term with spontaneous labor onset during the period of 1999-2014 in Norway. Read More

J Neonatal Perinatal Med 2020 Mar 5. Epub 2020 Mar 5.

Department of Obstetrics/Gynecology, Division of Maternal-Fetal Medicine, University of Washington Medical Center, Seattle, WA, USA.

Background: Gastroschisis is an abdominal wall defect wherein the bowel is herniated into the amniotic fluid. Controversy exists regarding optimal prenatal surveillance strategies that predict fetal well-being and help guide timing of delivery. Our objective was to develop a clinical care pathway for prenatal management of uncomplicated gastroschisis at our institution. Read More

BMC Pregnancy Childbirth 2020 Mar 4;20(1):139. Epub 2020 Mar 4.

Maternity Unit, Valme University Hospital, Seville, Spain.

Background: Gestational diabetes mellitus is associated with increased incidence of adverse perinatal outcomes including newborns large for gestational age, macrosomia, preeclampsia, polyhydramnios, stillbirth, and neonatal morbidity. Thus, fetal growth should be monitored by ultrasound to assess for fetal overnutrition, and thereby, its clinical consequence, macrosomia. However, it is not clear which reference curve to use to define the limits of normality. Read More

Gynecol Endocrinol 2020 Feb 19:1-6. Epub 2020 Feb 19.

Department of Endocrinology, Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.

The aim of this study was to explore the risk of perinatal outcomes in pre-gestational type 1 diabetes mellitus (T1DM) compared to gestational diabetes mellitus (GDM) and pregnancy without diabetes and to examine the association of glycemic level of third-trimester gestation with perinatal outcomes in T1DM. We included 69 pre-gestational T1DM, 1398 cases of GDM, and 1304 control pregnancies and collected data regarding demographics, obstetric, and perinatal outcomes from the hospital discharge database. Relative to the pregnancies without diabetes, women with T1DM encountered increasing risk of polyhydramnios, preterm delivery, and cesarean section. Read More

PLoS One 2020 13;15(2):e0227766. Epub 2020 Feb 13.

Reproductive Hospital Affiliated to Shandong University, Jinan, China.

Objective: In the present study, we aimed to determine whether pregravid obesity independently predicts increased risks of perinatal complications following in vitro fertilization (IVF) and the weight loss goals to reduce the risk of poor pregnancy outcomes.

Design: Retrospective cohort study.

Population: All pregnancies after first the fresh IVF cycle from January 2014 to December 2016 in the Reproductive Center affiliated to Shandong University were reviewed. Read More

Obstet Gynecol 2020 Mar;135(3):511-521

Center for Fetal Therapy, Department of Gynecology & Obstetrics, the Department of Anesthesiology and Critical Care Medicine, the Division of Maternal-Fetal Medicine, Department of Gynecology & Obstetrics, the Division of Neonatology and the Pediatric Intensive Care Unit, Department of Pediatrics, and the Division of Pediatric Surgery, Department of Surgery, Johns Hopkins University School Medicine, Baltimore, Maryland.

Objective: To assess feasibility and maternal and infant outcome after fetoscopic tracheal balloon occlusion in patients with severe congenital diaphragmatic hernia.

Methods: We conducted a prospective cohort study of fetuses with congenital diaphragmatic hernia and observed/expected lung/head ratio less than 30%. Eligible women had planned fetoscopic tracheal balloon occlusion at 26 0/7-29 6/7 weeks of gestation and balloon removal 4-6 weeks later. Read More

JA Clin Rep 2019 Nov 28;5(1):79. Epub 2019 Nov 28.

Department of Anesthesiology and Intensive Care, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.

Background: Amniotic fluid embolism (AFE) is a life-threatening obstetric emergency. Because the maternal mortality associated with AFE is very high, early recognition and prompt treatment are important for improving the prognosis. We report a case of amniotic fluid embolism successfully treated by multidisciplinary treatment. Read More

J Neonatal Perinatal Med 2020 Jan 27. Epub 2020 Jan 27.

Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine.

 Chorioangioma is a rare vascular placental tumour. Large chorioangiomas are known to have many maternal and perinatal complications. The case of placental chorioangioma detected via ultrasound is presented. Read More

J Obstet Gynaecol 2020 Jan 30:1-10. Epub 2020 Jan 30.

Department of Midwifery and Reproductive Health, Nursing and Midwifery School, Tehran University of Medical Sciences, Tehran, Iran.

β-thalassaemia major (BTM) has a high prevalence worldwide and is associated with considerable morbidity and mortality. The aim of this review is to provide an illustrative overview of the reproductive health and pregnancy related issues in females with β-thalassaemia. A literature search was performed in four international databases (1980-2018) to identify the potentially relevant articles. Read More

J Clin Ultrasound 2020 May 28;48(4):240-243. Epub 2020 Jan 28.

Klinik für Geburtsmedizin, Charité - Universitätsmedizin, Berlin, Germany.

We report the case of a fetus with sonographic characteristics of Beckwith-Wiedemann syndrome (BWS). A 30-year-old gravida 2 para 1 was referred to our fetal medicine unit with an omphalocele. Fetal macrosomia, organomegaly, and polyhydramnios but no macroglossia were detected and BWS was suspected. Read More

Orphanet J Rare Dis 2020 Jan 21;15(1):24. Epub 2020 Jan 21.

Department of Endocrinology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, 3333 Binsheng Rd, Hangzhou 310052, China.

Background: Prader-Willi syndrome (PWS) is a rare and complex genetic disorder caused by lacking expression of imprinted genes on the paternally derived chromosome 15q11-q13 region. This study aimed to characterize the perinatal features of 134 Chinese individuals with PWS.

Methods: This study included the patients of a PWS registry in China. Read More