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Sensors (Basel) 2022 Jun 17;22(12). Epub 2022 Jun 17.

Department of Computer Science, College of Computer Science and Information Technology, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia.

A fetal ultrasound (US) is a technique to examine a baby's maturity and development. US examinations have varying purposes throughout pregnancy. Consequently, in the second and third trimester, US tests are performed for the assessment of Amniotic Fluid Volume (AFV), a key indicator of fetal health. Read More

Diagnostics (Basel) 2022 May 28;12(6). Epub 2022 May 28.

Doctoral School, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.

Polyhydramnios is an obstetrical condition defined as a pathological increase in the amniotic fluid and is associated with a high risk of maternal-fetal complications. Common causes of polyhydramnios include fetal anatomical and genetic abnormalities, gestational diabetes mellitus, and fetal viral infections. We present the case of a 30-year-old Caucasian woman with transient polyhydramnios associated with gestational diabetes mellitus and obstetric complications. Read More

Children (Basel) 2022 Jun 16;9(6). Epub 2022 Jun 16.

Division of Genetics and Metabolism, Department of Pediatrics, MacKay Memorial Hospital, Taipei 10449, Taiwan.

Costello syndrome (CS) is a type of RASopathy caused mainly by de-novo heterozygous pathogenic variants in the gene located on chromosome 11p15.5. The phenotype of CS is characterized by prenatal overgrowth, postnatal failure to thrive, curly or sparse fine hair, coarse facial features, and multisystem involvement, including cardiovascular, endocrine, and gastroenterological disorders. Read More

Ultrasound Obstet Gynecol 2022 Jun 20. Epub 2022 Jun 20.

Department of Biostatistics, University of Arkansas for the Medical Sciences, Little Rock, AR.

Objective: To analyze pregnancy outcomes in singleton pregnancies with idiopathic polyhydramnios by a systematic review and meta-analysis of controlled trials.

Methods: The research team utilized systematic review methodology to identify all items within published and grey literature resources. A medical librarian conducted a literature search of over twenty unique databases, collections and grey resources in the fall of 2019. Read More

Zhongguo Zhong Yao Za Zhi 2022 May;47(10):2811-2818

Department of Nutrition and Toxicology, School of Public Health, Hangzhou Normal University Hangzhou 311121, China Center for Uterine Cancer Diagnosis and Therapy Research, the Affiliated Women's Hospital, Zhejiang University Hangzhou 310006, China.

The present study evaluated the effect of Shenqi Jiangtang Granules(SJG) combined with western medicine on the adverse pregnancy outcomes in women with gestational diabetes mellitus(GDM). PubMed, Web of Science, CNKI, Wanfang, and VIP were searched for clinical randomized controlled trials(RCTs) of SJG combined with western medicine against GDM. The included RCTs were assessed for risks using the assessment criteria recommended by the Cochrane handbook for systematic reviews of interventions. Read More

Asian J Endosc Surg 2022 Jun 17. Epub 2022 Jun 17.

Department of Pediatric Surgery, Research Field in Medical and Health Sciences, Medical and Dental Area, Research and Education Assembly, Kagoshima University, Kagoshima, Japan.

Introduction: Management of neonates with long gap esophageal atresia (LGEA) is one of the most challenging situations facing pediatric surgeons. Delayed anastomosis after internal traction for esophageal lengthening was reported as a useful technique for long gap cases. Additionally, the use of near-infrared (NIR) fluorescence imaging with indocyanine green (ICG) has gained popularity in pediatric surgery, especially for blood perfusion validation. Read More

Am J Obstet Gynecol 2022 Jun 6. Epub 2022 Jun 6.

Department of Anesthesiology, Perioperative and Pain Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States.

Background: Tranexamic acid is frequently administered for postpartum hemorrhage. The World Health Organization recommends 1g intravenous dosing repeated once at 30 minutes for ongoing bleeding. Understanding the pharmacokinetics and pharmacodynamics of tranexamic acid in patients at high risk for PPH may enable dosage tailoring for optimal antifibrinolysis with minimal adverse events such as thrombosis or renal cortical necrosis. Read More

Arch Gynecol Obstet 2022 Jun 9. Epub 2022 Jun 9.

Department of Obstetrics and Gynecology, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, POB 151, 84101, Beer-Sheva, Israel.

Purpose: To evaluate changes in the independent contribution of different risk factors for placental abruption over time.

Methods: In this retrospective nested case-control study, trends of change in ORs for known risk factors for placental abruption occurring in three consecutive 8-year intervals were compared. A univariate assessment of factors associated with placental abruption and two multivariable logistic regression models were constructed to identify independent risk factors for placental abruption. Read More

Comput Intell Neurosci 2022 27;2022:8658999. Epub 2022 May 27.

Shandong Provincial Maternal and Child Health Care Hospital, Jinan City, Shandong Province, China.

Objective: To explore the prenatal ultrasonographic characteristics and pregnancy outcomes of fetal meconium peritonitis (FMP).

Methods: Nine patients diagnosed with FMP by routine prenatal examination between January 2015 and December 2020 were identified. Both prenatal ultrasonographic characteristics and pregnancy outcomes associated with these patients were retrospectively analyzed. Read More

JNMA J Nepal Med Assoc 2022 Mar 11;60(247):229-233. Epub 2022 Mar 11.

Nepal Medical College and Teaching Hospital, Jorpati, Kathmandu, Nepal.

Introduction: Gestational diabetes mellitus is increasing globally leading to significant maternal and foetal morbidity. This study aimed to find out the prevalence of gestational diabetes mellitus among pregnant women delivering in a tertiary care hospital.

Methods: A descriptive cross-sectional study on a total of 3034 pregnant women was conducted in a tertiary care hospital from 14th April 2017 to 13th April 2018 with ethical approval from Research and Institutional Review Committee (Reference number: 061-077/078) of the hospital. Read More

J Matern Fetal Neonatal Med 2022 May 22:1-6. Epub 2022 May 22.

Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Mount Sinai West, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Objective: There is no consensus for the method of aneuploidy screening in pregnancy. Cell free DNA (cfDNA) is the most sensitive screen for trisomies 21, 13, and 18, however the first trimester screen (FTS) is a marker for other adverse outcomes, such as structural anomalies, growth restriction, and preeclampsia. In 2019, we offered FTS (nuchal translucency (NT) and analytes) with or without cfDNA. Read More

Saudi J Med Med Sci 2022 May-Aug;10(2):166-169. Epub 2022 Apr 28.

Department of Pediatrics, Thumbay University Hospital, Ajman, UAE.

Bonneau or cardio-ducto-polysyndactyly syndrome is an extremely rare, life-threatening developmental defect, which has only been reported in eight patients previously. Here, we describe one such case of Bonneau syndrome in a newborn with additional novel manifestations. This late preterm (35 weeks of gestation) neonate born to parents of consanguineous marriage following a pregnancy complicated by polyhydramnios was symmetrically small for date at birth (<3 centile for weight, length, and occipitofrontal circumference). Read More

BMC Pregnancy Childbirth 2022 May 18;22(1):418. Epub 2022 May 18.

Department of Obstetrics, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China.

Background: To investigate the epidemiological, clinical characteristics and outcomes of diabetes in pregnancy (DIP).

Methods: This single-center, retrospective study included 16,974 pregnant women hospitalized during 2018-2019. Among them, 2860 DIP patients were grouped according to diabetes type, glycemic status, and insulin use. Read More

Kardiol Pol 2022 May 17. Epub 2022 May 17.

Department of Perinatal Cardiology and Congenital Anomalies, Center of Postgraduate Medical Education, Warszawa, Poland.

Background: Tetralogy of Fallot (TOF) is a common congenital heart disease, however very heterogenous in terms of detailed cardiac anatomy, associated malformations and genetic anomalies, especially when assessed prenatally.

Aims: Our aim was to analyze the clinical spectrum of TOF in the prenatal period, including detailed cardiac morphology, coexisting anomalies, and their impact on short-term neonatal outcome. We also assessed changing trends in the prenatal diagnostic workup of TOF. Read More

BMC Pregnancy Childbirth 2022 May 11;22(1):399. Epub 2022 May 11.

Social Determinants of Health Research Center, Yasuj University of Medical Sciences, Yasuj, Iran.

Background: In this prospective cohort study, the perinatal outcome in idiopathic polyhydramnios compared with normal pregnancies was examined.

Methods: This was a prospective cohort study of 180 singleton pregnancies who received care at the referral gynecology clinic of Yasuj, Iran between 2018-2020. The inclusion criteria comprised singleton pregnancies, gestational age > 34 weeks; fetuses without structural and chromosomal abnormalities in pregnancy screening test, no maternal diabetes, negative TORCH negative screening test, no Rh factor isoimmunization. Read More

Fetal Diagn Ther 2022 Apr 29. Epub 2022 Apr 29.

Introduction: Congenital pulmonary airway malformations (CPAM) complicated by hydrops portends significant morbidity and mortality, with fetal survival estimates less than 10%.

Case Presentation: We report successful use of ultrasound-guided radio-frequency ablation at 21 weeks gestation in a hydropic fetus with CPAM, with subsequent resolution of hydrops. 32 week MRI noted persistent mediastinal shift, and US at 36 weeks and 5days noted polyhydramnios. Read More

Best Pract Res Clin Obstet Gynaecol 2022 Mar 31. Epub 2022 Mar 31.

Department of Maternal-Fetal Medicine, Hospital Civil de Guadalajara "Dr. Juan I. Menchaca", Jalisco, Mexico.

Up to 20% of monochorionic diamniotic twin pregnancies can be complicated with twin-to-twin transfusion syndrome (TTTS). This complication is diagnosed by ultrasound demonstrating amniotic fluid discordance between both amniotic sacs, with polyhydramnios in the recipient's sac and oligohydramnios in the donor's, secondary to an imbalance in blood volume exchange between twins. Ultrasound evaluation of the amniotic fluid volume, bladder filling, and assessment of fetal Doppler parameters provide the basis for classification of TTTS, allowing severity assessment. Read More

Medicine (Baltimore) 2022 Apr 22;101(16):e29222. Epub 2022 Apr 22.

Xuzhou Central Hospital, Xuzhou Clinical Schools of Xuzhou Medical University and Nanjing Medical University, Xuzhou, Jiangsu, China.

Rationale: The purpose of this report was to explore how to manage the fetus of Simpson-Golabi-Behmel syndrome type 1 (SGBS1) and to provide a definite diagnosis to guide the following genetic counseling for the pregnancy.

Patient Concerns: A 24-year-old women, gravida 1, para 0, was 172 cm tall with weight 65 kg. She was referred to our center for counseling due to second-trimester ultrasound screening anomalies at 22 + 5 weeks of gestation age. Read More

Best Pract Res Clin Obstet Gynaecol 2022 Mar 29. Epub 2022 Mar 29.

Department of Obstetrics, Gynecology and Reproductive Services, University of Texas Health Science Center at Houston, United States; The Fetal Center at Children's Memorial Hermann Hospital, United States. Electronic address:

Twin reverse arterial perfusion (TRAP) sequence is a severe anomaly in monochorionic twins where one twin has profound corporeal underdevelopment and acardia. The normal "pump" co-twin provides blood flow to the acardiac twin through placental anastomoses which may lead to cardiac failure and pump twin demise as well as preterm delivery from severe polyhydramnios. Treatments include radiofrequency ablation, bipolar cord coagulation, and intrafetal laser with each aimed at occluding blood flow to the acardiac twin. Read More

BMJ Case Rep 2022 Apr 22;15(4). Epub 2022 Apr 22.

Obstetrics, Kantonsspital, Sankt Gallen, SG, Switzerland.

The case presented here shows the rare diagnosis of fetal otocephaly with lethal prognosis due to impossible airway management after birth. Otocephaly is characterised by fetal agnathia, microstomia and synotia. As in our case, otocephaly is usually not recognised until the third trimester and leads to challenging clinical situations and decision making. Read More

Acta Obstet Gynecol Scand 2022 Jul 20;101(7):787-793. Epub 2022 Apr 20.

Fetal Medicine Unit, Women's Centre, John Radcliffe Hospital, Oxford, UK.

Introduction: Ultrasound assessment of fetuses subjected to hyperglycemia is recommended but, apart from increased size, little is known about its interpretation, and the identification of which large fetuses of diabetic pregnancy are at risk is unclear. Newer markers of adverse outcomes, abdominal circumference growth velocity and cerebro-placental ratio, help to predict risk in non-diabetic pregnancy. Our study aims to assess their role in pregnancies complicated by diabetes. Read More

Pediatr Res 2022 Apr 7. Epub 2022 Apr 7.

Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.

Background: The pathogenesis of bronchopulmonary dysplasia (BPD) is multifactorial, and there are limited data about prenatal exposures and risk of BPD.

Study Design: Our study performed parallel analyses using a logistic regression model in a cohort of 4527 infants with data from a curated registry and using a phenome wide association study (PheWAS) based on ICD9/10-based phecodes. We examined 20 prenatal exposures from a neonatal intensive care unit (NICU) curated registry database related to pregnancy and maternal health as well as 94 maternal diagnosis phecodes with a PheWAS analysis. Read More

Diabetes Metab Syndr Obes 2022 31;15:973-981. Epub 2022 Mar 31.

Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201600, People's Republic of China.

Objective: The present study aims to evaluate the relationship of thyroid function during the first trimester of pregnancy with lipid levels and pregnancy outcomes.

Methods: Women who delivered babies at the Shanghai General Hospital between March 2019 and December 2019 with a known pregnancy outcome and complete data were included in the present study (n = 1779). A retrospective cohort study of all subjects with available first-trimester thyroid function testing and lipid levels data was conducted, and the relationship of thyroid function with lipid levels and pregnancy outcomes was evaluated. Read More

Orphanet J Rare Dis 2022 04 4;17(1):149. Epub 2022 Apr 4.

Affiliated Dongguan Maternal and Child Health Care Hospital, Southern Medical University, Dongguan, 523120, China.

Background: Homozygous or compound heterozygous variants in the KLHL40 gene cause nemaline myopathy 8 (NEM8), a severe autosomal recessive muscle disorder characterized by prenatal polyhydramnios, fetal akinesia or hypokinesia, joint contractures, fractures, respiratory failure and dysphagia. Currently, 46 individuals with NEM8 have been described in the literature, and 30 variants in KLHL40 have been identified.

Results: Here, we reported five individuals from four unrelated Chinese families who presented common features of nemaline myopathy and infrequent clinical characteristics. Read More

Eur J Med Genet 2022 May 1;65(5):104501. Epub 2022 Apr 1.

Department of Fetal Medicine & Medical Imaging, Corniche Hospital, Abu Dhabi, United Arab Emirates; College of Medicine and Health Sciences, Khalifa University, Abu Dhabi, United Arab Emirates.

We report on three male siblings who presented prenatally with a nearly identical combination of congenital anomalies and who died shortly after preterm birth. The first baby was a singleton pregnancy, and the other two babies were dichorionic diamniotic twins. Key features included: left-sided congenital diaphragmatic hernia, inferior vermian dysgenesis/hypoplasia, prenasal edema, cleft palate, micropenis/ambiguous genitalia (in 2 of 3 babies), bilateral renal pelvic dilatation (in twins, first baby showed slightly enlarged kidneys) and polyhydramnios (in 2 of 3). Read More

BMC Med Genomics 2022 03 30;15(1):73. Epub 2022 Mar 30.

Fujian Provincial Key Laboratory for Prenatal Diagnosis and Birth Defect, Medical Genetic Diagnosis and Therapy Center of Fujian Provincial Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University, No. 18 Daoshan Road, Fuzhou City, 350001, Fujian Province, China.

Background: Polyhydramnios, the excessive accumulation of amniotic fluid, is associated with an elevated risk of abnormal karyotype, particularly aneuploidy. Studies focusing on chromosomal microarray analysis (CMA) in pregnancies with polyhydramnios are limited. The aim of this study is to evaluate the implications of pregnancy with polyhydramnios by CMA testing and routine karyotyping. Read More

Arch Gynecol Obstet 2022 Mar 28. Epub 2022 Mar 28.

Department of Obstetrics & Gynecology, Galilee Medical Center, PO Box 21, 22100, Nahariya, Israel.

Purpose:  The clinical implications of gestational diabetes mellitus (GDM) diagnosed in the third trimester are not well established and controversy continues regarding the performance of diagnostic tests beyond 28-week gestation. This study aimed to evaluate the incidence of abnormal third trimester oral glucose tolerance test (OGTT) results in women at high risk and to compare the obstetric and neonatal outcomes with those of women with normal OGTT results.

Methods:  The study included 372 women who completed late (>29 weeks) 100-g OGTT due to suspected fetal macrosomia, polyhydramnios or a personal risk factor for GDM, diagnosed according to the Carpenter & Coustan criteria. Read More

Best Pract Res Clin Gastroenterol 2022 Feb-Mar;56-57:101785. Epub 2022 Feb 5.

Department of Pediatric Nutrition, Gastroenterology and Hepatology, Hôpital des enfants de Toulouse, 330, avenue de Grande Bretagne, TSA 70034, 31059 Toulouse cedex 9, France; CHU de Toulouse, France.

Congenital diarrhea may result from 2 main different mechanisms: 1) osmotic diarrhea is caused by the non-digestion-absorption of nutrients leading to the non-absorbed nutrients going into the lumen, increasing the osmotic force and driving fluids; 2) secretory diarrhea induced by the inhibition of intestinal absorption of electrolytes, increasing electrolyte and water flux towards the intestinal lumen. The malabsorption of macronutrients (carbohydrates, proteins and lipids) induces energy deficiency with symptoms depending on the macronutrient: carbohydrates with watery acidic diarrhea; protein with rapid malnutrition, edema, and hypoalbuminemia; and lipids with malnutrition, steatorrhea and hypocholesterolemia. Ionic malabsorption (Cl and Na) is responsible for severe and rapid dehydration sometimes with prenatal abnormalities (polyhydramnios and bowel dilatation). Read More

Best Pract Res Clin Gastroenterol 2022 Feb-Mar;56-57:101784. Epub 2022 Jan 4.

Department of Genetics, Hôpital Necker-Enfants Malades, 149, Rue de Sèvres, 75743, PARIS Cedex 15, France.

Congenital enteropathies (CE) are a group of rare inherited diseases with a typical onset early in life. They involve defects in enterocyte structure or differentiation. They can cause a severe condition of intestinal failure (IF). Read More

J Ultrasound Med 2022 Mar 21. Epub 2022 Mar 21.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Maine Medical Center, Portland, ME, USA.

Objectives: To compare maternal and perinatal outcomes in pregnancies with transient and persistent idiopathic polyhydramnios to those with normal amniotic fluid volume.

Methods: This retrospective cohort study included subjects delivering a singleton pregnancy between January 1, 2015, and June 30, 2020, with sonography ≥26 weeks' gestation demonstrating transient or persistent idiopathic polyhydramnios (amniotic fluid index [AFI] ≥24.0 cm) or normal AFI (referent group). Read More