14 results match your criteria Polygonatum odoratum Mill. Druce

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Homoisoflavonoids Are Potent Glucose Transporter 2 (GLUT2) Inhibitors: A Potential Mechanism for the Glucose-Lowering Properties of Polygonatum odoratum.

J Agric Food Chem 2018 Mar 19;66(12):3137-3145. Epub 2018 Mar 19.

The MOE Key Laboratory for Standardization of Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica , Shanghai University of Traditional Chinese Medicine , 1200 Cailun Road , Shanghai 201203 , P. R. China.

Foods of high carbohydrate content such as sucrose or starch increase postprandial blood glucose concentrations. The glucose absorption system in the intestine comprises two components: sodium-dependent glucose transporter-1 (SGLT1) and glucose transporter 2 (GLUT2). Here five sappanin-type (SAP) homoisoflavonoids were identified as novel potent GLUT2 inhibitors, with three of them isolated from the fibrous roots of Polygonatum odoratum (Mill. Read More

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March 2018
5 Reads
2.91 Impact Factor

Can highly cited herbs in ancient Traditional Chinese medicine formulas and modern publications predict therapeutic targets for diabetes mellitus?

J Ethnopharmacol 2018 Mar 2;213:101-110. Epub 2017 Nov 2.

The MOE Key Laboratory for Standardization of Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, PR China. Electronic address:

Ethnopharmacological Relevance: The prevalence of diabetes among all age groups worldwide was estimated to be more than 382 million in 2013. Traditional Chinese medicine (TCM) has been practiced for thousands of years, and substantial valuable experience and prescriptions have been accumulated in the TCM system for the treatment of diabetes. In recent decades, a large amount of experimental and clinical data has been published on the use of herbal medicines related to these ancient TCM prescriptions. Read More

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March 2018
11 Reads

Steroidal sapogenins and glycosides from the fibrous roots of Polygonatum odoratum with inhibitory effect on tissue factor (TF) procoagulant activity.

Steroids 2014 Nov 17;89:1-10. Epub 2014 Jul 17.

Department of Complex Prescription of Traditional Chinese Medicine, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, PR China. Electronic address:

Six new spirostane glycosides (1-6), named polygodosides A-F, one new furostanol glycoside, polygodoside G (7), one new cholestane glycoside, polygodoside H (8), and one new steroidal sapogenin, polygodosin A (9), together with thirteen known compounds (10-22) were isolated from a 90% MeOH extract of the fibrous roots of Polygonatum odoratum (Mill.) Druce. The structures of new compounds were elucidated by extensive 1D and 2D NMR spectroscopic analyses and mass spectrometry. Read More

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November 2014
28 Reads

Molecular switch role of Akt in Polygonatum odoratum lectin-induced apoptosis and autophagy in human non-small cell lung cancer A549 cells.

PLoS One 2014 3;9(7):e101526. Epub 2014 Jul 3.

Department of Pharmacy, Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, Chengdu, China; Center for Perinatal Research, Nationwide Children's Hospital, Columbus, Ohio, United States of America.

Polygonatum odoratum lectin (POL), isolated from traditional Chinese medicine herb (Mill.) Druce, has drawn rising attention due to its wide biological activities. In the present study, anti-tumor effects, including apoptosis- and autophagy-inducing properties of POL, were determined by a series of cell biology methods such as MTT, cellular morphology observation, flow cytometry, immunoblotting. Read More

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October 2015
20 Reads

Extracts of Rhizoma polygonati odorati prevent high-fat diet-induced metabolic disorders in C57BL/6 mice.

PLoS One 2013 29;8(11):e81724. Epub 2013 Nov 29.

School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Polygonatum odoratum (Mill.) Druce belongs to the genus Polygonatum family of plants. In traditional Chinese medicine, the root of Polygonatum odoratum, Rhizoma Polygonati Odorati, is used both for food and medicine to prevent and treat metabolic disorders such as hyperlipidemia, hyperglycemia, obesity and cardiovascular disease. Read More

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December 2014
3 Reads

A dihydrochalcone and several homoisoflavonoids from Polygonatum odoratum are activators of adenosine monophosphate-activated protein kinase.

Bioorg Med Chem Lett 2013 Jun 17;23(11):3137-9. Epub 2013 Apr 17.

Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, Shandong 250062, PR China.

Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a major cellular energy sensor and master regulator of metabolic homeostasis; thus, AMPK plays a central role in studies on diabetes and related metabolic diseases. From the rhizomes of Polygonatum odoratum (Mill.) Druce, six homoisoflavonoids (1-6) and one dihydrochalcone (7) were isolated, and the structures of polygonatones A-D (4-7) were elucidated by various spectroscopic analyses. Read More

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June 2013
5 Reads

Saponin rich fractions from Polygonatum odoratum (Mill.) Druce with more potential hypoglycemic effects.

J Ethnopharmacol 2012 May 17;141(1):228-33. Epub 2012 Feb 17.

Chemistry Institute of Pharmaceutical Resources, College of Pharmaceutical Sciences, Southwest University, Chongqing 400716, PR China.

Aims: The root of Polygonatum odoratum (YuZhu), also a medicinal food has long been used for the treatment of diabetes. The objective of the study was to characterize the anti-diabetic active fractions or compounds in this herb.

Materials And Methods: Fractions with a different polarity were prepared by solvent extraction and macroporous absorptive resin (D101) column and their anti-diabetic potentials were evaluated by glucose uptake in HepG2 cells and STZ-induced diabetic rats. Read More

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May 2012
4 Reads

Characterization, molecular cloning, and in silico analysis of a novel mannose-binding lectin from Polygonatum odoratum (Mill.) with anti-HSV-II and apoptosis-inducing activities.

Phytomedicine 2011 Jun 13;18(8-9):748-55. Epub 2010 Dec 13.

School of Life Sciences & State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, China.

Polygonatum odoratum lectin (POL), a novel mannose-binding lectin with anti-viral and apoptosis-inducing activities, was isolated from rhizomes of Polygonatum odoratum (Mill.) Druce. POL was a homo-tetramer with molecular weight of 11953. Read More

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June 2011
3 Reads

[New homoisoflavanones from Polygonatum odoratum (Mill.) Druce].

Yao Xue Xue Bao 2009 Jul;44(7):764-7

Department of Natural Products, Drug Discovery of North China Pharmaceutical Company, Shijiazhuang 050015, China.

To study chemical constituents of Polygonatum odoratum (Mill.) Druce, the compounds were separated with column chromatography and HPLC. On the basis of physicochemical properties and spectral data, their structures were confirmed. Read More

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July 2009
1 Read

A steroidal glycoside from Polygonatum odoratum (Mill.) Druce. improves insulin resistance but does not alter insulin secretion in 90% pancreatectomized rats.

Biosci Biotechnol Biochem 2002 Oct;66(10):2036-43

Department of Internal Medicine, Konkuk University, Kyohyun-Dong, Chungioo-Si, Chungbuk-Do, Korea.

The aim of this study was to investigate the effects of three steroidal glycosides (SG-100, SG-280, and SG-460) obtained from Polygonatum odoratum (Mill.) Druce. on insulin secretion, insulin action, and relative glucose uptake in various tissues of 90% pancreatectomized male Sprague-Dawley rats. Read More

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October 2002
1 Read

[Studies on the active constituents of the Chinese traditional medicine Polygonatum odoratum (Mill.) Druce].

Yao Xue Xue Bao 1994 ;29(3):215-22

School of Pharmacy, Second Military Medical University, Shanghai.

From the ethanol extract of the Chinese traditional medicine, rhizomes of Polygonatum odoratum, a new steroidal saponin POD-II together with beta-sitosterol and its glucoside, and three known saponins were isolated. On the basis of chemical evidence and spectral analysis (UV, IR, EI-MS, 1HNMR and 13CNMR), the structure of POD-II was elucidated as 3-O-beta-D-glucopyranosyl-(1-->2)-[beta-D-xylopyranosyl-(1-->3)]-beta-D- glucopyranosyl-(1-->4)-galactopyranosyl-25(R)-spirost-5-en-3 beta,14 alpha-diol. Preliminary pharmacological tests showed that POD-II could induce the colony stimulating factor (CSF) in mouse serum; and POD-III, at the concentration of 0. Read More

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September 1994
1 Read

[Effects of alcohol extract from Polygonatum odoratum (Mill.) Druce and Cuscuta australis R. Br. on immunological function of mice injured by burns].

Zhongguo Zhong Yao Za Zhi 1990 Sep;15(9):557-9, 578

Department of Radiation Medicine, Second Military Medical College, Shanghai.

This paper shows that the alcoholic extract from Polygonatum odoratum and Cuscuta australis increases the percentage of phagocytosis and the index of phagocytosis of macrophages as well as hemolysin and proliferation of lymphocytes up to normal level in mice with II+ burn injury covering 5% body surface. It follows that both Polygonatum odoratum and Cuscuta australis may serve as a kind of immunopotentiator for mammals. Read More

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September 1990
1 Read
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