71 results match your criteria Polyglandular Autoimmune Syndrome Type III


Induction of remission in autoimmune polyglandular syndrome type three (APS III): An old drug with new perspectives.

Clin Case Rep 2018 Nov 2;6(11):2178-2184. Epub 2018 Oct 2.

Internal Medicine Department, Faculty of Medicine Alexandria University Alexandria Egypt.

The autoimmune polyglandular syndrome is a sequential chain of autoimmune events. Whenever diagnosed, the clinician's target should be induction of remission and if possible hindering its progression especially if associated with refractory vitiligo, resistant Grave's, or unexplained hyperglycemia in T1DM. Azathioprine could be used for induction of remission in autoimmune polyglandular syndrome type three especially with vitiligo and autoimmune thyroiditis. Read More

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http://dx.doi.org/10.1002/ccr3.1827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230650PMC
November 2018
18 Reads

Aggressive treatment in paediatric or young patients with drug-induced hypersensitivity syndrome (DiHS)/drug reaction with eosinophilia and systemic symptoms (DRESS) is associated with future development of type III polyglandular autoimmune syndrome.

BMJ Case Rep 2018 Oct 27;2018. Epub 2018 Oct 27.

Department of Dermatology, Kawasaki Medical School, Kurashiki, Okayama, Japan.

We experienced a 6-year-old case of drug-induced hypersensitivity syndrome (DiHS)/drug reaction with eosinophilia and systemic symptoms (DRESS) with subsequent development autoimmune thyroiditis (Hashimoto's thyroiditis), type 1 diabetes with antithyroglobulin, thyroid peroxidase, insulinoma-associated antigen and anti-insulin antibodies at 4 months, alopecia at 7 months, vitiligo, uveitis due to Vogt-Koyanagi-Harada disease at 8 months after clinical resolution of the DiHS/DRESS. He was diagnosed as type III polyglandular autoimmune syndrome (PASIII) after DiHS/DRESS. Prompted by this case, we sought to determine which triggering factors were responsible for later development of PASIII in previously published cases with autoimmune sequelae. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22552
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http://dx.doi.org/10.1136/bcr-2018-225528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214396PMC
October 2018
10 Reads

Anti-Saccharomyces Cerevisiae as Unusual Antibody in Autoimmune Polyglandular Syndrome Type III: A Case Report.

Endocr Metab Immune Disord Drug Targets 2019 ;19(1):90-94

Department of Neurology, Gozde Akademi Hospital Malatya, Ankara asfalti 6. Km No:219, 44110 Yesilyurt/ Malatya, Turkey.

Backgraund and Objective: Anti-Saccharomyces Cerevisiae Antibodies (ASCA) that are considered to reflect immune response against increased intestinal permeability due to mucosal damage are among the serological markers of Crohn's Disease.

Methods: This microbial seromarker was recently shown to be elevated in several autoimmune disorders such as celiac disease, autoimmune liver diseases, type 1 diabetes, and Graves' disease. Despite that fact, ASCA seropositivity in Autoimmune Polyglandular Syndrome (APS) has never been reported before. Read More

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http://www.eurekaselect.com/164747/article
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http://dx.doi.org/10.2174/1871530318666180817143536DOI Listing
January 2019
20 Reads

15-Year old girl with APS type IIIc, 12 months post-thymectomy remission of myasthenia.

Pediatr Endocrinol Diabetes Metab 2017 ;23(1):49-55

Department of Pediatrics, Endocrinology and Diabetes with a Cardiology Unit, Medical University in Bialystok, Poland.

Polyglandular autoimmune syndromes (PAS) is a group of heterogenous conditions characterized by the association of at least two organ-specific autoimmune disorders, concerning both endocrine and non-endocrine organs. Type III is defined as the combination of autoimmune thyroid disease and other autoimmune condition (other than Addison's disease) and is divided into four subtypes. We describe a teenage female patient - with the family history of autoimmune diseases, who has simultaneously developed the symptoms of autoimmune thyroid disease with the clinical picture of hyperthyroidism and myasthenia gravis at the age of fifteen. Read More

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http://pediatricendocrinology.pl/?doi=10.18544/PEDM-23.01.00
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http://dx.doi.org/10.18544/PEDM-23.01.0074DOI Listing
June 2018
4 Reads

Altered expression of circadian clock genes in polyglandular autoimmune syndrome type III.

Endocrine 2018 01 7;59(1):109-119. Epub 2017 Sep 7.

Department of Biological Chemistry, School of Medicine, National and Kapodistrian University of Athens, Athens, 11527, Greece.

Purpose: Circadian timing system is a highly conserved, ubiquitous molecular "clock" which creates internal circadian rhythmicity. Dysregulation of clock genes expression is associated with various diseases including immune dysregulation. In this study we investigated the circadian pattern of Clock-related genes in patients with polyglandular autoimmune syndrome type III (PAS type III). Read More

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http://dx.doi.org/10.1007/s12020-017-1407-1DOI Listing
January 2018
33 Reads
3.530 Impact Factor

Polyglandular Autoimmune Syndrome in pregnancy: case report.

Ital J Gynaecol Obstet 2016 Sep;28(4):35-40

Division of Gynecology and Obstetrics, Maternal and Child Department, Cannizzaro Hospital, Catania, Italy.

Type III Polyglandular Autoimmune Syndrome is a multiple endocrine disorders disease determined by autoimmunity; it can be diagnosed if a patient is affected by Type 1 Diabetes Mellitus and another autoimmune disease, except Addison Disease, for example Autoimmune Hashimoto Thyroiditis or Celiac Disease. R.D. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5132407PMC
September 2016
14 Reads

Polyglandular autoimmune syndrome type III with a prevalence of cutaneous features.

Authors:
A Capo P Amerio

Clin Exp Dermatol 2017 Jan 13;42(1):61-63. Epub 2016 Nov 13.

Department of Medicine and Aging Science, Dermatologic Clinic, University G. d'Annunzio, Chieti, Italy.

Polyglandular autoimmune syndrome (PAS) is the name given to a group of autoimmune disorders of the endocrine glands. PAS type III (PAS III) comprises several autoimmune diseases (autoimmune thyroiditis, immune-mediated diabetes mellitus, pernicious anaemia, vitiligo, alopecia areata and many others) and is subdivided into four subcategories. We report the case of a 52-year-old woman with autoimmune thyroiditis, vitiligo, alopecia areata, psoriasis and lichen sclerosus, suggesting a clinical diagnosis of PAS IIIC with a singular prevalence of cutaneous features. Read More

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http://dx.doi.org/10.1111/ced.12984DOI Listing
January 2017
14 Reads

[Psycho-immuno-endocrinology of the thyroid gland].

Vnitr Lek Fall 2016;62(9 Suppl 3):107-114

Historically endocrinologists and psychiatrists are aware that disturbances in thyroid disease in beginning or even in clinically intensified states of thyrotoxicosis or hypothyroidism exhibit pathological mental manifestations, masking or potentiating the underlying disease. Immune system disorders cause thyroid organ-specific autoimmune process. This autoimmune thyroid disease binds with a number of disorders in both endocrine or non-endocrine organs. Read More

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June 2017
31 Reads

Deep vein thrombosis, an unreported first manifestation of polyglandular autoimmune syndrome type III.

Endocrinol Diabetes Metab Case Rep 2016 28;2016. Epub 2016 Jul 28.

Walter Reed National Military Medical Center , Bethesda, Maryland , USA.

Unlabelled: A 71-year-old woman with severe right lower leg pain, edema and erythema was presented to the Emergency Department and was found to have an extensive deep vein thrombosis (DVT) confirmed by ultrasound. She underwent an extensive evaluation due to her prior history of malignancy and new hypercoagulable state, but no evidence of recurrent disease was detected. Further investigation revealed pernicious anemia (PA), confirmed by the presence of a macrocytic anemia (MCV=115. Read More

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http://dx.doi.org/10.1530/EDM-16-0034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967110PMC
August 2016
7 Reads

Clinical course and therapeutic approach to varicella zoster virus infection in children with rheumatic autoimmune diseases under immunosuppression.

Pediatr Rheumatol Online J 2016 Jun 2;14(1):34. Epub 2016 Jun 2.

Pediatric Rheumatology, University of Basel Children's Hospital, Spitalstrasse 33, CH - 4031, Basel, Switzerland.

Background: To analyze the clinical presentation and complications of varicella zoster virus (VZV) infection in children with rheumatic diseases treated with immunosuppressive medication such as biological disease-modifying antirheumatic drugs (bDMARDs) and/or conventional disease-modifying antirheumatic drugs (cDMARDs), and to analyze the therapeutic approach to VZV infections with respect to the concomitant immunosuppressive treatment.

Methods: Retrospective multicenter study using the Swiss Pediatric Rheumatology registry. Children with rheumatic diseases followed in a Swiss center for pediatric rheumatology and treated with cDMARD and/or bDMARD with a clinical diagnosis of varicella or herpes zoster between January 2004 and December 2013 were included. Read More

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http://dx.doi.org/10.1186/s12969-016-0095-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890263PMC
June 2016
19 Reads

Association of TNF-α, CTLA4, and PTPN22 polymorphisms with type 1 diabetes and other autoimmune diseases in Brazil.

Genet Mol Res 2015 Dec 28;14(4):18936-44. Epub 2015 Dec 28.

Laboratório de Imunopatologia Keiso Asami, Universidade Federal de Pernambuco, Recife, PE, Brasil.

Type 1 diabetes mellitus (T1D) is a complex disorder characterized by an autoimmune response against human pancreatic beta-cells. Patients with T1D can also develop a response toward one or more other factors, such as in autoimmune thyroiditis (AITD) and celiac disease (CD). In the presence of T1D + AITD, the patient is diagnosed with autoimmune polyglandular syndrome type III (APSIII); patients with APSIII may also present with CD. Read More

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http://www.funpecrp.com.br/gmr/year2015/vol14-4/pdf/gmr5470.
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http://dx.doi.org/10.4238/2015.December.28.42DOI Listing
December 2015
5 Reads

Meta-analysis of STAT4 and IFIH1 polymorphisms in type 1 diabetes mellitus patients with autoimmune polyglandular syndrome type III.

Genet Mol Res 2015 Dec 22;14(4):17730-8. Epub 2015 Dec 22.

Departamento de Genética, Universidade Federal de Pernambuco, Recife, PE, Brasil.

Type 1 diabetes mellitus (T1D) is an organ-specific autoimmune disease characterized by T-cell mediated self-destruction of insulin-producing β cells in the pancreas. T1D patients are prone to develop other glandular autoimmune disorders, such as autoimmune thyroid disease that occurs simultaneously with autoimmune polyglandular syndrome type III (APSIII). Signal transducer and activator of transcription 4 (STAT4) is a well-known regulator of proinflammatory cytokines, and interferon-induced with helicase C domain 1 (IFIH1) is activated in the interferon type I response. Read More

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http://dx.doi.org/10.4238/2015.December.21.46DOI Listing
December 2015
3 Reads

COEXISTENCE OF ADDISON'S DISEASE AND PERNICIOUS ANEMIA: IS THE NEW CLASSIFICATION OF AUTOIMMUNE POLYGLANDULAR SYNDROME APPROPRIATE?

Acta Clin Croat 2015 Jun;54(2):232-5

A case of autoimmune polyglandular syndrome (APS) is presented. A 45-year-old man was admitted due to fatigue, malaise and inappetence. He had a history of primary hypothyroidism and was on levothyroxine substitution therapy. Read More

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June 2015
9 Reads

Short Communication FYB polymorphisms in Brazilian patients with type I diabetes mellitus and autoimmune polyglandular syndrome type III.

Genet Mol Res 2015 Jan 15;14(1):29-33. Epub 2015 Jan 15.

Departamento de Genética, Universidade Federal de Pernambuco, Recife, PE, Brasil.

The aim of this study was to perform an association study between seven Fyn-binding protein gene (FYB)-tag single nucleotide polymorphisms (SNPs) and type I diabetes mellitus (T1DM), as well as with disease age of onset. We also assessed the role of FYB SNPs in the insurgence of autoimmune polyglandular syndrome type III (APSIII), characterized by the simultaneous presence of autoimmune thyroid disease and celiac disease, in patients with T1DM from a Northeastern Brazilian population. One hundred and seventy-seven patients with T1DM and 190 healthy individuals were genotyped for seven tag SNPs, covering most of the FYB locus, using real-time polymerase chain reaction amplification. Read More

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http://dx.doi.org/10.4238/2015.January.15.4DOI Listing
January 2015
3 Reads

Type 1 diabetes and polyglandular autoimmune syndrome: A review.

World J Diabetes 2015 Feb;6(1):67-79

Martin P Hansen, Nina Matheis, George J Kahaly, Department of Medicine I, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany.

Type 1 diabetes (T1D) is an autoimmune disorder caused by inflammatory destruction of the pancreatic tissue. The etiopathogenesis and characteristics of the pathologic process of pancreatic destruction are well described. In addition, the putative susceptibility genes for T1D as a monoglandular disease and the relation to polyglandular autoimmune syndrome (PAS) have also been well explored. Read More

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http://www.wjgnet.com/1948-9358/pdf/v6/i1/67.pdf
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http://www.wjgnet.com/1948-9358/full/v6/i1/67.htm
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http://dx.doi.org/10.4239/wjd.v6.i1.67DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317318PMC
February 2015
5 Reads

Polyglandular Syndrome Type III and Severe Peripheral Neuropathy: An Unusual Association.

GE Port J Gastroenterol 2015 Jan-Feb;22(1):15-18. Epub 2015 Jan 12.

Internal Medicine Department, Universidade Federal da Paraíba, Paraíba, Brazil.

Introduction: Polyglandular syndrome is characterized by the association of autoimmune, organ-specific, endocrine and non-endocrine diseases.

Objective: To present a case of polyglandular syndrome type III (b) accompanied by pernicious anemia and autoimmune thyroiditis.

Method: Report the clinical case of a young patient that developed progressive and disabling peripheral neuropathy framework, triggered by vitamin B12 deficiency. Read More

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http://dx.doi.org/10.1016/j.jpge.2014.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580155PMC
January 2015
12 Reads

Quality of life and related factors in a cohort of plaque-type psoriasis patients in La Coruña, Spain.

Int J Dermatol 2014 Nov 30;53(11):e507-11. Epub 2014 Sep 30.

Department of Dermatology, University Hospital of La Coruña, La Coruña, Spain.

Background: Psoriasis can significantly affect the physical, psychological, and social aspects of a patient's life. Many studies have evaluated the effects of psoriasis on quality of life (QoL), but results in many cases are contradictory.

Objectives: This study was conducted to assess the relationships between the characteristics of psoriasis (cutaneous severity, arthropathy, treatment) and comorbidities with QoL and to determine which factors have a major influence. Read More

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http://dx.doi.org/10.1111/ijd.12294DOI Listing
November 2014
10 Reads

A case of autoimmune urticaria accompanying autoimmune polyglandular syndrome type III associated with Hashimoto's disease, type 1 diabetes mellitus, and vitiligo.

Endokrynol Pol 2014 ;65(4):320-3

We present a case of autoimmune polyglandular syndrome type III (APS III) associated with Hashimoto's disease, type 1 diabetes mellitus, vitiligo and autoimmune urticaria. This rare genetic disorder occurs with unknown frequency in the Polish population. It is characterised by endocrine tissue destruction resulting in the malfunction of multiple organs. Read More

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http://dx.doi.org/10.5603/EP.2014.0044DOI Listing
October 2016
15 Reads

[Type III polyglandular autoimmune syndrome: a case report].

Rev Esp Geriatr Gerontol 2014 Sep-Oct;49(5):244-5. Epub 2014 Jul 2.

Universidad Libre, Cali, Colombia.

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http://dx.doi.org/10.1016/j.regg.2014.03.004DOI Listing
June 2016
8 Reads

Autoimmune polyglandular syndrome in a woman of 51 years.

Eur Rev Med Pharmacol Sci 2014 ;18(12):1717-9

Department of Clinical Medicine, Sapienza University of Rome, Rome, Italy.

Introduction: Autoimmune polyglandular syndromes (APS) are constellations of symptoms and signs of multiple glandular insufficiencies. We report a rare case of type III APS in a female patient.

Case Report: A 51-year-old woman was treated with radiotherapy because of thymus hyperplasia when she was two years old; she was diagnosed with celiac disease and autoimmune hypothyroidism at 41 years old and with sicca syndrome and myasthenia gravis seronegative a few years later. Read More

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April 2015
2 Reads

A case of nonischemic cardiomyopathy associated with autoimmune polyglandular syndrome type III.

Endocr Pract 2014 Oct;20(10):e183-6

Department of Endocrinology, Cairns Hospital, Cairns, Australia.

Objective: To report a case of nonischemic dilated cardiomyopathy associated with autoimmune polyglandular syndrome (APS) type III.

Methods: A review of our patient's medical records was undertaken, and her clinical history, investigations, and outcome are described. In addition, a literature review of nonischemic dilated cardiomyopathy occurring in association with autoimmune polyendocrinopathies was performed. Read More

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http://dx.doi.org/10.4158/EP14053.CRDOI Listing
October 2014
8 Reads

Polyglandular Autoimmune Syndrome Type III with Primary Hypoparathyroidism.

Endocrinol Metab (Seoul) 2013 Sep 13;28(3):236-40. Epub 2013 Sep 13.

Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea.

Polyglandular autoimmune syndrome is defined as multiple endocrine gland insufficiencies accompanied by autoimmune diseases of the endocrine and nonendocrine system. After Schmidt introduced a case of nontuberculosis adrenal gland dysfunction with thyroiditis in 1926, Neufeld defined polyglandular autoimmune syndrome by I, II, and III subtypes in 1980 by their presentation of occurrence age, heredity methods, relationship with human leukocyte antigen, and accompanying diseases. We report a case of a 32-year-old female with polyglandular autoimmune syndrome III accompanied by type 1 diabetes mellitus that was treated with insulin (36 units per day) for 11 years. Read More

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http://dx.doi.org/10.3803/EnM.2013.28.3.236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811692PMC
September 2013
6 Reads

HLA class II haplotypes differentiate between the adult autoimmune polyglandular syndrome types II and III.

J Clin Endocrinol Metab 2014 Jan 20;99(1):E177-82. Epub 2013 Dec 20.

Laboratory of Immunogenetics/HLA (B.K.F., C.W.), German Red Cross Blood Service West, Bad Kreuznach 55543, Germany; Molecular Thyroid Research Laboratory (N.M., G.J.K.), Johannes Gutenberg University Medical Center, Mainz 55101, Germany; Bioinformatics Unit (T.A.) and Center for Transfusion Medicine (J.B.), German Red Cross Blood Service West, Hagen 58097, Germany.

Background: Genetics of the adult autoimmune polyglandular syndrome (APS) is poorly understood.

Aim: The aim of this study was to gain further insight into the genetics of the adult APS types. SITE: The study was conducted at a university referral center. Read More

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http://dx.doi.org/10.1210/jc.2013-2852DOI Listing
January 2014
3 Reads

Autoimmune polyglandular syndrome III in a patient with idiopathic portal hypertension.

Intern Med 2013 ;52(12):1375-8

Department of Diabetes and Endocrinology, Wakayama Medical Center Japanese Red Cross Society, Japan.

A 42-year-old woman with a history of idiopathic portal hypertension (IPH) developed type 1A diabetes and was found to have chronic thyroiditis. The concurrence of IPH and type 1A diabetes has been previously reported in only one case. This is the second known case, and our patient was classified as having autoimmune polyglandular syndrome (APS) III. Read More

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February 2014
5 Reads

Type III Polyglandular Autoimmune Syndromes in children with type 1 diabetes mellitus.

Ann Agric Environ Med 2013 ;20(1):140-6

Department of Paediatric Endocrinology and Diabetology, Medical University, Lublin, Poland.

Introduction: Type III Polyglandular Autoimmune Syndrome (PAS III) is composed of autoimmune thyroid diseases associated with endocrinopathy other than adrenal insufficiency. This syndrome is associated with organ-specific and organ-nonspecific or systemic autoimmune diseases. The frequency of PAS syndromes in diabetic children is unknown. Read More

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September 2013
9 Reads

[Cardiac symptoms in a patient with Addison's disease and hypothyreosis on the basis of autoimmune polyglandular syndrome type II].

Vnitr Lek 2012 Jun;58(6):473-6

III. interní - kardiologická klinika 3. lékarské fakulty UK a FN Královské Vinohrady Praha.

In many endocrine diseases we can find a heart disorder. We present a case of a young patient aged 34 years, who was examined for non-specific ST-T abnormalities on ECG and a new-diagnosed left ventricle dysfunction with suspicion to the acute coronary syndroma. However, this diagnosis wasn't verified. Read More

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June 2012
6 Reads

Intestinal lymphangiectasia in a patient with autoimmune polyglandular syndrome type III.

J Assoc Physicians India 2011 Nov;59:729-31

Department of Endocrinology, Gauhati Medical College, Guwahati, 781032, India.

Autoimmune polyglandular syndromes (APS) comprise a wide clinical spectrum of autoimmune disorders. APS is divided into Type I, Type II, Type I and Type IV depending upon the pattern of disease combination. Ghronic diarrhoea is one of the many manifestations of APS and many aetiological factors have been suggested for it. Read More

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November 2011
10 Reads

[59 year-old man with skin and eye alterations and diabetes mellitus].

Authors:
N Ewald R G Bretzel

Dtsch Med Wochenschr 2012 May 27;137(19):997-8. Epub 2012 Apr 27.

Medizinische Klinik und Poliklinik III, Universitätsklinikum Gießen und Marburg GmbH, Standort Gießen.

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http://dx.doi.org/10.1055/s-0032-1304893DOI Listing
May 2012
2 Reads

HLA-DRB1/DQB1 susceptibility for autoimmune polyglandular syndrome type II and III in south of Tunisia.

Ann Endocrinol (Paris) 2011 Jun 8;72(3):232-8. Epub 2011 Jun 8.

Immunology Department, Habib Bourguiba Hospital, University of Sfax, Tunisia.

Objectives: The aim of our study was to investigate the association of HLA-DRB1 and HLA-DQB1 alleles with autoimmune polyglandular syndromes (APS) type II and III in a southern Tunisian population.

Patients And Methods: Sixty-two unrelated patients with APSII (n=20) and APSIII (n=42) and 146 healthy controls were genotyped for HLA class II alleles (DRB1*, DQB1*) by PCR-SSP technique.

Results: An increased frequencies of HLA-DQB1*03:02 (P=0,02; OR=2. Read More

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http://dx.doi.org/10.1016/j.ando.2011.04.004DOI Listing
June 2011
7 Reads

Functional type 1 regulatory T cells develop regardless of FOXP3 mutations in patients with IPEX syndrome.

Eur J Immunol 2011 Apr 14;41(4):1120-31. Epub 2011 Mar 14.

San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, Milan, Italy.

Mutations of forkhead box p3 (FOXP3), the master gene for naturally occurring regulatory T cells (nTregs), are responsible for the impaired function of nTregs, resulting in an autoimmune disease known as the immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome. The relevance of other peripheral tolerance mechanisms, such as the presence and function of type 1 regulatory T (Tr1) cells, the major adaptive IL-10-producing Treg subset, in patients with IPEX syndrome remains to be clarified. FOXP3(mutated) Tr1-polarized cells, differentiated in vitro from CD4(+) T cells of four IPEX patients, were enriched in IL-10(+) IL-4(-) IFN-γ(+) T cells, a cytokine production profile specific for Tr1 cells, and expressed low levels of FOXP3 and high levels of Granzyme-B. Read More

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http://dx.doi.org/10.1002/eji.201040909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107421PMC
April 2011
7 Reads

A case of type 1 diabetes onset and recurrence of Graves' disease during pegylated interferon-α plus ribavirin treatment for chronic hepatitis C.

Intern Med 2010 15;49(18):1987-90. Epub 2010 Sep 15.

Department of Internal Medicine, Mishuku Hospital, Tokyo.

We report a case of type 1 diabetes onset and recurrence of Graves' disease during pegylated interferon (PEG-IFN)-alpha plus ribavirin treatment for chronic hepatitis C. The patient was a 55-year-old woman diagnosed with chronic hepatitis at age 46 years. She was treated for Graves' disease at 50 years of age. Read More

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August 2011
13 Reads

Two novel cosegregating mutations in tRNAMet and COX III, in a patient with exercise intolerance and autoimmune polyendocrinopathy.

Mitochondrion 2009 Apr 21;9(2):123-9. Epub 2009 Jan 21.

Child Neurology and Psychiatry Unit, Institute of Child Health IRCCS, Burlo Garofolo, Via dell'Istria 65/1, 34137 Trieste, Italy.

We report a 12-year-old patient with growth retardation, exercise intolerance, lactic acidosis (increasing after exercise) and autoimmune polyendocrinopathy type 2. Muscle biopsy shows abundant COX-negative fibers, subsarcolemmal mitochondrial aggregates and markedly reduced activities of all respiratory chain complexes. Genetic analysis identified two new cosegregating mutations in Met-tRNA (m. Read More

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http://dx.doi.org/10.1016/j.mito.2009.01.006DOI Listing
April 2009
7 Reads

Polyglandular autoimmune syndromes.

Authors:
George J Kahaly

Eur J Endocrinol 2009 Jul 1;161(1):11-20. Epub 2009 May 1.

Department of Medicine I, Gutenberg University Medical Centre, Mainz 55101, Germany.

The polyglandular autoimmune syndromes (PAS) comprise a wide spectrum of autoimmune disorders and are divided into a very rare juvenile (PAS type I) and a relatively common adult type with (PAS II) or without adrenal failure (PAS III). First clinical manifestation of PAS I usually occurs in childhood, whereas PAS II mostly occurs during the third and fourth decades. PAS I is caused by mutations in the autoimmune regulatory (AIRE) gene on chromosome 21 and is inherited in an autosomal recessive manner. Read More

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http://dx.doi.org/10.1530/EJE-09-0044DOI Listing
July 2009
5 Reads

[Prevalence of polyglandular autoimmune syndrome in patients with diabetes mellitus type 1].

Med Klin (Munich) 2009 Mar 1;104(3):183-91. Epub 2009 Apr 1.

Klinik für Innere Medizin III, Universitätsklinikum Jena, Jena.

Background And Purpose: The aim of this study was to examine the prevalence of autoimmune antibodies (autoimmune hypophysitis, adrenalitis, thyropathy, pernicious anemia, celiac disease) and clinically relevant endocrine autoimmune disease (AIEK) in patients with type 1 diabetes in the course of 1 year.

Patients And Methods: Antibody screening was performed in 139 diabetic patients (age 44 +/- 14 years; years since diagnosis 26 +/- 15 years; duration of diabetes 18 +/- 12 years; body mass index 26 +/- 4 kg/m(2); HbA(1c) 7.5% +/- 1. Read More

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http://dx.doi.org/10.1007/s00063-009-1030-xDOI Listing
March 2009
9 Reads

[Polyglandular activation of autoimmnunity as a manifestation of subclinical endocrinopathies].

Cas Lek Cesk 2007 ;146(3):256-61

Ustav imunologie a mikrobiologie 1. LF UK a VFN, Praha.

Background: Autoimmune thyropathies belong to the most frequently occurring autoimmune endocrinopathies. Autoimmune thyropathies occur either independently or linked to known polyglandular syndromes of type I-III.

Methods And Results: During the last decade, we observed a group of patients with autoimmune thyroiditis, in which autoimmune endocrinopathies were mutually associated and named the symptoms of this group "polyglandular activation of autoimmunity". Read More

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June 2007
3 Reads

[The case of autoimmune polyglandular syndrome of type III].

Lik Sprava 2006 Jul-Sep(5-6):67-8

Autoimmune polyglandular thyroiditis case of type III syndrome is represented in the article along with physical, laboratory and instrumental data. Read More

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April 2007
5 Reads

A case of polyglandular autoimmune syndrome type III complicated with autoimmune hepatitis.

Endocr J 2006 Oct 1;53(5):705-9. Epub 2006 Sep 1.

Department of Molecular and Internal Medicine, Graduate School Biomedical Sciences, Hiroshima University, Kasumi, Hiroshima, Japan.

A 58-year-old woman complaining of finger tremor was referred to our hospital. The diagnosis of Graves' disease was made based on increased free triiodothyronine (18.88 pg/ml) and free thyroxine (7. Read More

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October 2006
8 Reads

Expression profiling of autoimmune regulator AIRE mRNA in a comprehensive set of human normal and neoplastic tissues.

Immunol Lett 2006 Aug 28;106(2):172-9. Epub 2006 Jul 28.

Department of Internal Medicine III, Johannes-Gutenberg University Mainz, Obere Zahlbacherstr 63, 55131 Mainz, Germany.

Defects in the autoimmune regulator (AIRE) gene cause the monogenic autoimmune disease autoimmune polyendocrinopathy syndrome type 1 (APS-1), which is characterized by a loss of self-tolerance to multiple organs. In concordance with its role in immune tolerance, AIRE is strongly expressed in medullary thymic epithelial cells (mTECs). Data on mechanisms controlling AIRE activation and the expression of this gene in other tissues are fragmentary and controversial. Read More

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http://dx.doi.org/10.1016/j.imlet.2006.06.006DOI Listing
August 2006
8 Reads

Anti-interferon autoantibodies in autoimmune polyendocrinopathy syndrome type 1.

PLoS Med 2006 Jul;3(7):e289

Biotherapeutics, National Institute for Biological Standards and Control, South Mimms, United Kingdom.

Background: The autoimmune regulator (AIRE) gene influences thymic self-tolerance induction. In autoimmune polyendocrinopathy syndrome type 1 (APS1; OMIM 240300), recessive AIRE mutations lead to autoimmunity targetting endocrine and other epithelial tissues, although chronic candidiasis usually appears first. Autoimmunity and chronic candidiasis can associate with thymomas as well. Read More

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http://dx.doi.org/10.1371/journal.pmed.0030289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1475653PMC
July 2006
9 Reads

Susceptibility alleles and haplotypes of human leukocyte antigen DRB1, DQA1, and DQB1 in autoimmune polyglandular syndrome type III in Japanese population.

Horm Res 2005 27;64(5):253-60. Epub 2005 Oct 27.

Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi University, Nankoku, Japan.

Background: It has been reported that HLA class II haplotypes DRB1*0405-DQA1*0303-DQB1*0401 and DRB1*0901-DQA1*0302-DQB1*0303 are major susceptibility haplotypes for type 1 diabetes mellitus (DM) in Japanese population. However, little has been reported on the susceptibility HLA class II haplotypes in Japanese patients with autoimmune polyglandular syndrome type II and type III (APS III).

Patients And Methods: HLA class II haplotypes of DRB1-DQA1-DQB1 in 31 patients with APS III, 14 patients with Hashimoto's thyroiditis alone, and 15 patients with Graves' disease alone were examined in Japanese population. Read More

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http://dx.doi.org/10.1159/000089293DOI Listing
December 2005
9 Reads

Autoimmune hepatitis in India: profile of an uncommon disease.

BMC Gastroenterol 2005 Aug 15;5:27. Epub 2005 Aug 15.

Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014 (UP), India.

Background: Autoimmune hepatitis (AIH) has been reported to show considerable geographical variation in frequency and clinical manifestations. It is considered a rare cause of liver disease in India. The present study was undertaken to determine the incidence, clinical, biochemical and histological profile of AIH in this part of the world. Read More

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http://dx.doi.org/10.1186/1471-230X-5-27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1236920PMC
August 2005
11 Reads
8 Citations
2.370 Impact Factor

[Alopecia totalis, hypotension and erectile dysfunction in a 34 year old patient. Difficult clarification of a common cause].

Internist (Berl) 2005 Jun;46(6):690-4

Funktionsbereich Endokrinologie und Stoffwechselerkrankungen, Klinik für Innere Medizin III, Universitätsklinikum Jena.

The occurrence of both autoimmune endocrinopathies and endocrinopathies caused by other reasons is called polyglandular autoimmune syndrome (PAS-syndrome). In a 34 years old man with weakness, weight loss and erectile dysfunction we found low cortisol caused by an autoimmune adrenalitis and low testosterone caused by a hypophysitis with impaired gonadotropin secretion. Thyroid autoantibodies and islet cell autoantibodies without any hormone deficiencies were further signs of a broad endocrine autoimmune syndrome. Read More

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http://dx.doi.org/10.1007/s00108-005-1380-2DOI Listing
June 2005
4 Reads

Slowly progressive type 1 diabetes mellitus associated with vitiligo vulgaris, chronic thyroiditis, and pernicious anemia.

Intern Med 2004 Dec;43(12):1183-5

Department of Endocrinology, Aomori Prefectural Central Hospital, Aomori.

A 81-year-old woman was diagnosed as having diabetes mellitus (DM) at 58 years of age. She started insulin therapy the following year, but her blood sugar levels were poorly controlled. At the age of 75, she tested positive for the anti-GAD antibody (7. Read More

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December 2004
10 Reads

Polyglandular autoimmune syndrome type III accompanied by common variable immunodeficiency.

Gynecol Endocrinol 2004 Jul;19(1):47-50

Department of Endocrinology and Metabolism, Dicle University, School of Medicine, Diyarbakir, Turkey.

We identified polyglandular autoimmune (PGA) syndrome type III in a 24-year-old nurse with common variable immunodeficiency (CVID). An immune-mediated disorder, membranoproliferative glomerulonephritis, was diagnosed when she was 15 years old. Clinical examination and laboratory findings revealed a PGA syndrome due to the presence of hypergonadotropic hypogonadism, insufficient growth hormone response and thyroid autoimmunity. Read More

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July 2004
6 Reads

Autoimmune polyglandular syndrome type III in monozygotic twins: a case report.

Acta Clin Belg 2004 Jul-Aug;59(4):225-8

Division of Endocrinology and Metabolism, Faculty of Medicine, University of Trakya, Edirne, Turkey.

Autoimmune polyglandular syndrome is characterized by the coexistence of several autoimmune diseases, affecting predominantly the endocrine glands. Autoimmune polyglandular syndrome type III, as a subdivision of autoimmune polyglandular syndrome type II, is the co-occurrence of autoimmune thyroid disease with other autoimmune disorders without Addison disease. We present a rare case of autoimmune polyglandular syndrome type III in monozygotic twins. Read More

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January 2005
7 Reads

Defective suppressor function of human CD4+ CD25+ regulatory T cells in autoimmune polyglandular syndrome type II.

J Exp Med 2004 May 26;199(9):1285-91. Epub 2004 Apr 26.

Department of Medicine III, Institute for Clinical Immunology and Rheumatology, University of Erlangen-Nuremberg, Germany.

In autoimmune polyglandular syndromes (APS), several organ-specific autoimmune diseases are clustered. Although APS type I is caused by loss of central tolerance, the etiology of APS type II (APS-II) is currently unknown. However, in several murine models, depletion of CD4(+) CD25(+) regulatory T cells (T(regs)) causes a syndrome resembling human APS-II with multiple endocrinopathies. Read More

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http://dx.doi.org/10.1084/jem.20032158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211900PMC
May 2004
8 Reads

Thyroid hemiagenesis and autoimmune polyglandular syndrome type III.

J Endocrinol Invest 2003 Nov;26(11):1160-1

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http://dx.doi.org/10.1007/BF03345267DOI Listing
November 2003
3 Reads