Sex hormone binding globulin - an important biomarker for predicting PCOS risk: A systematic review and meta-analysis.
Syst Biol Reprod Med 2017 Dec 11:1-13. Epub 2017 Dec 11.
a Centre for Medical Biotechnology, Maharshi Dayanad University , Haryana , India.
Sex hormone-binding globulin (SHBG) is a glycoprotein which regulates bioavailability of sex steroid hormones. Interest in SHBG has escalated in recent years because of its inverse association with polycystic ovary syndrome (PCOS), obesity, insulin resistance, metabolic syndrome, and diabetes type II. This meta-analysis was performed to examine the associations of SHBG with PCOS and to correlate serum SHBG levels with various PCOS associated endocrine and metabolic dysregulation as well as to determine the effects of various therapeutic agents on serum SHBG levels in PCOS patients in order to assess the true accuracy of SHBG in the prediction of PCOS. Read More