21,478 results match your criteria Polycystic Ovarian Syndrome

Hippo Signaling in the Ovary: Emerging roles in development, fertility, and disease.

Endocr Rev 2022 May 21. Epub 2022 May 21.

Olson Center for Women's Health, Department of Obstetrics and Gynecology, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA.

Emerging studies indicate that the Hippo pathway, a highly conserved pathway that regulates organ size control, plays an important role in governing ovarian physiology, fertility, and pathology. Specific to the ovary, the spatiotemporal expression of the major components of the Hippo signaling cascade are observed throughout the reproductive lifespan. Observations from multiple species begin to elucidate the functional diversity and molecular mechanisms of Hippo signaling in the ovary in addition to the identification of interactions with other signaling pathways and responses to various external stimuli. Read More

View Article and Full-Text PDF

Ethnic diversity and burden of polycystic ovary syndrome among US adolescent females.

J Pediatr Endocrinol Metab 2022 May 23. Epub 2022 May 23.

Graduate Medical Education, Kaiser Permanente Oakland Medical Center, Oakland, CA, USA.

Objectives: Polycystic Ovary Syndrome (PCOS) is a common female endocrine disorder presenting as early as adolescence. Recent data suggest that Asians may be at increased risk. This study examines PCOS prevalence by race/ethnicity in a large, diverse population of adolescent females. Read More

View Article and Full-Text PDF

Bovine models for human ovarian diseases.

Prog Mol Biol Transl Sci 2022 25;189(1):101-154. Epub 2022 Mar 25.

Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL, United States.

During early embryonic development, late fetal growth, puberty, adult reproductive years, and advanced aging, bovine and human ovaries closely share molecular pathways and hormonal signaling mechanisms. Other similarities between these species include the size of ovaries, length of gestation, ovarian follicular and luteal dynamics, and pathophysiology of ovarian diseases. As an economically important agriculture species, cattle are a foundational species in fertility research with decades of groundwork using physiologic, genetic, and therapeutic experimental techniques. Read More

View Article and Full-Text PDF

Mitochondrial and glucose metabolic dysfunctions in granulosa cells induce impaired oocytes of polycystic ovary syndrome through Sirtuin 3.

Free Radic Biol Med 2022 May 17. Epub 2022 May 17.

Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, 310006, China. Electronic address:

Mitochondrial function and glucose metabolism play important roles in bidirectional signaling between granulosa cells (GCs) and oocytes. However, the factors associated with mitochondrial function and glucose metabolism of GCs in polycystic ovary syndrome (PCOS) are poorly understood, and their potential downstream effects on oocyte quality are still unknown. The aim of this study was to investigate whether there are alterations in mitochondrial-related functions and glucose metabolism in ovarian GCs of women with PCOS and the role of Sirtuin 3 (SIRT3) in this process. Read More

View Article and Full-Text PDF

Challenges in diagnosis and understanding of natural history of polycystic ovary syndrome.

Clin Endocrinol (Oxf) 2022 May 20. Epub 2022 May 20.

Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.

Polycystic ovary syndrome (PCOS) is the most common endocrinopathy affecting 8-13% of reproductive-aged women. The aetiology of the syndrome is complex, with genetic susceptibility, androgen exposure in early life and adiposity related dysfunction leading to perturbance in hypothalamic-ovarian function. PCOS clinical features are heterogeneous, with manifestations arising even in early adolescence, developing into multisystem reproductive, metabolic and psychological manifestations in adulthood. Read More

View Article and Full-Text PDF

Insights into new therapeutic approaches for the treatment and management of polycystic ovary syndrome: An updated review.

Curr Pharm Des 2022 May 18. Epub 2022 May 18.

Departments of Endocrinology and Clinical Research, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir India.

Background: Polycystic ovary syndrome (PCOS) is a long-term, highly prevalent, complex heterogeneous, polygenic endocrine disorder characterized by both metabolic and reproductive disorders. It affects 6-23% of reproductive age women globally.

Objective: This review aims to facilitate an understanding of novel PCOS management approaches and highlights the results from relevant interventional studies from animal and human studies. Read More

View Article and Full-Text PDF

The Association Between Serum Estradiol Levels on hCG Trigger Day and Live Birth Rates in Non-PCOS Patients: A Retrospective Cohort Study.

Front Endocrinol (Lausanne) 2022 3;13:839773. Epub 2022 May 3.

Hebei Key Laboratory of Infertility and Genetics, Hebei Clinical Research Center for Birth Defects, Department of Reproductive Medicine, Second Hospital of Hebei Medical University, Shijiazhuang, China.

Objective: To retrospectively analyze the association of serum estradiol (E2) levels on human chorionic gonadotropin (hCG) trigger day and live birth rates (LBRs) in women undergoing fresh embryo transfer and not exhibiting polycystic ovary syndrome.

Design: Retrospective cohort study.

Methods: Analysis of 13,950 patients who had fresh embryo transfer between December 2013 and December 2019. Read More

View Article and Full-Text PDF

Human umbilical cord mesenchymal stem cell-derived exosomes inhibit ovarian granulosa cells inflammatory response through inhibition of NF-κB signaling in polycystic ovary syndrome.

J Reprod Immunol 2022 May 12;152:103638. Epub 2022 May 12.

Center for Reproductive Medicine, The Fourth Hospital of Shijiazhuang, Gynecology and Obstetrics Hospital Affiliated to Hebei Medical University, Shijiazhuang 050011, Hebei, China; The Institute of Reproductive Health and Infertility, Shijiazhuang 050011, Hebei, China. Electronic address:

Polycystic ovary syndrome (PCOS) is a common endocrine disorder and the leading cause of anovulatory infertility in women of reproductive age. Chronic low-grade inflammation is considered to be the major contributors to ovarian dysfunction. Human umbilical mesenchymal stem cell-derived exosomes (hUC-MSC-exos) have been proven to exhibit highly effective anti-inflammatory ability. Read More

View Article and Full-Text PDF

Analysis and prediction of risk factors of ovarian hyperstimulation caused by Long-acting GnRH agonist protocol in follicular phase.

Eur Rev Med Pharmacol Sci 2022 May;26(9):3261-3268

Department of Gynecology, Department of Reproductive Center, Fujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian Province, China.

Objective: The aim of the study was to explore the risk factors of ovarian hyperstimulation in patients undergoing long-acting gonadotropin-releasing hormone (GnRH) agonist protocol in follicular phase of ovulation induction therapy and to establish a predictive model.

Patients And Methods: A total of 1289 patients who received Long-acting GnRH agonist protocol in follicular phase for ovulation induction in the Fujian Provincial Maternity and Child Health Hospital from July 1, 2018, to July 31, 2019, were selected. Among them, 33 patients developed moderate/severe ovarian hyperstimulation syndrome. Read More

View Article and Full-Text PDF

Prevalence, incidence and years lived with disability due to polycystic ovary syndrome in 204 countries and territories, 1990-2019.

Hum Reprod 2022 May 19. Epub 2022 May 19.

Robinson Research Institute, The University of Adelaide, Adelaide, South Australia, Australia.

Study Question: What is the global, regional and national burden of polycystic ovary syndrome (PCOS), by age and socio-demographic index (SDI), over the period 1990-2019?

Summary Answer: In 2019, the global age-standardized point prevalence, incidence and years lived with disability (YLD) of PCOS were 30.4, 29.5 and 29. Read More

View Article and Full-Text PDF

Low Serum 25-Hydroxyvitamin D Levels Are Associated With Hyperandrogenemia in Polycystic Ovary Syndrome: A Cross-Sectional Study.

Front Endocrinol (Lausanne) 2022 2;13:894935. Epub 2022 May 2.

Department of Endocrinology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.

Background: Increasing evidence suggests a link between vitamin D and polycystic ovary syndrome (PCOS). However, whether vitamin D is related to hyperandrogenemia in PCOS is still inconclusive. The aim of our study is to elucidate the relationship between vitamin D and hyperandrogenemia in women with PCOS in China. Read More

View Article and Full-Text PDF

Does asporin have a role in polycystic ovary syndrome? A pilot study.

Rev Assoc Med Bras (1992) 2022 May;68(5):653-657

Near East University Hospital, Department of Biochemistry - Nicosia, Cyprus.

Objective: Asporin is secreted by theca cells in the mouse ovaries and is an effective marker at the gonadotropin-independent stage in secondary follicle development. It has an inhibitory effect on transforming growth factor beta and bone morphogenic proteins, which are involved in androgenesis process. Our aim was to compare serum asporin levels of polycystic ovary syndrome and control groups and examine the relationship between asporin and hyperandrogenism. Read More

View Article and Full-Text PDF

Changes in eating behavior through lifestyle treatment in women with polycystic ovary syndrome (PCOS): a randomized controlled trial.

J Eat Disord 2022 May 17;10(1):69. Epub 2022 May 17.

Department of Psychiatry, Section Medical Psychology and Psychotherapy, Erasmus MC, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands.

Background: Eating behaviors like emotional eating, external eating and restrained eating play an important role in weight gain and weight loss in the general population. Improvements in eating behavior are important for long-term weight. This has not yet been studied in women with Polycystic Ovary Syndrome (PCOS). Read More

View Article and Full-Text PDF

Polycystic Ovary Syndrome and the Neuroendocrine Consequences of Androgen Excess.

Compr Physiol 2022 Mar 29;12(2):3347-3369. Epub 2022 Mar 29.

Centre for Neuroendocrinology, Department of Physiology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.

Polycystic ovary syndrome (PCOS) is a major endocrine disorder strongly associated with androgen excess and frequently leading to female infertility. Although classically considered an ovarian disease, altered neuroendocrine control of gonadotropin-releasing hormone (GnRH) neurons in the brain and abnormal gonadotropin secretion may underpin PCOS presentation. Defective regulation of GnRH pulse generation in PCOS promotes high luteinizing hormone (LH) pulsatile secretion, which in turn overstimulates ovarian androgen production. Read More

View Article and Full-Text PDF

Association between obesity in women with polycystic ovary syndrome and adverse obstetric outcomes.

Reprod Biomed Online 2022 Feb 15. Epub 2022 Feb 15.

McGill University, McGill University Health Center, Reproductive Center, Department of Obstetrics and Gynecology, MUHC Reproductive center, McGill University, 888, Boulevard de Maisonneuve East, Suite 200, Montreal QC H2L 4S8, Canada. Electronic address:

Research Question: How does the presence of obesity modify the risks for adverse obstetric outcomes in women with polycystic ovary syndrome (PCOS)?

Design: Retrospective population-based cohort study using data from the Healthcare Cost and Utilization Project Nationwide Inpatient Sample, 2004-2014. A total of 14,855 women with PCOS were identified (study group: obese women with PCOS [BMI ≥30 kg/m] [n = 3286]; reference group: remaining women with PCOS [n =11 569]). Logistic regression analysis was used to explore the associations between obesity, pregnancy, delivery and neonatal outcomes. Read More

View Article and Full-Text PDF
February 2022

Polycystic Ovary Syndrome and Metabolic Syndrome: Clinical and Laboratory Findings and Non-Alcoholic Fatty Liver Disease Assessed by Elastography.

Rev Bras Ginecol Obstet 2022 Mar 16;44(3):287-294. Epub 2022 May 16.

Department of Gynecology, Universidade Federal do Ceará, Fortaleza, CE, Brazil.

Objective:  To evaluate the association between polycystic ovary syndrome (PCOS) and metabolic syndrome (MetS), adding liver assessment through elastography and ultrasound, for correlation with non-alcoholic fatty liver disease (NAFLD). Metabolic syndrome occurs in ∼ 43% of women with PCOS, and NAFLD is the hepatic expression of MetS.

Methods:  One hundred women, 50 with PCOS and 50 controls, matched by age (18-35 years) and body mass index (BMI) were included, restricted to patients with overweight and obesity grade 1, at the Assis Chateaubrian Maternity School, Universidade Federal do Ceará, Brazil. Read More

View Article and Full-Text PDF

A Systematic Review and Meta-Analysis of the Association Between Polycystic Ovary Syndrome and Coronary Artery Calcification.

J Womens Health (Larchmt) 2022 May 16. Epub 2022 May 16.

Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Polycystic ovary syndrome (PCOS) is a common endocrine pathology affecting women of reproductive age characterized by chronic anovulation, hyperandrogenism, and polycystic ovaries. Coronary artery calcification (CAC) is a marker of subclinical atherosclerosis and prognostic of cardiovascular disease (CVD) risk. Some studies have shown that women with PCOS have a greater risk of CAC; however, a few others report contrary findings. Read More

View Article and Full-Text PDF

The Role of Fibroblast Growth Factor 19 Subfamily in Different Populations Suffering From Osteoporosis.

Front Endocrinol (Lausanne) 2022 28;13:830022. Epub 2022 Apr 28.

Department of Endocrinology and Metabolism, The Affiliated Hospital of Jiangsu University, Zhenjiang, China.

Fibroblast growth factor (FGF) 19 subfamily, also known as endocrine fibroblast growth factors (FGFs), is a newly discovered metabolic regulator, including FGF19, FGF21 and FGF23. They play significant roles in maintaining systemic homeostasis, regulating the balance of bile acid and glucolipid metabolism in humans. Osteoporosis is a chronic disease, especially in the current status of aging population, osteoporosis is the most prominent chronic bone disease, leading to multiple complications and a significant economic burden that requires long-term or even lifelong management. Read More

View Article and Full-Text PDF

Effect of lncRNA MALAT1 on the Granulosa Cell Proliferation and Pregnancy Outcome in Patients With PCOS.

Front Endocrinol (Lausanne) 2022 27;13:825431. Epub 2022 Apr 27.

Key Laboratory of Reproductive Genetics, Ministry of Education, Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Follicle arrest is one of the main characteristics of polycystic ovary syndrome (PCOS), the most common endocrinological disorder in reproductive-aged women. Increasing evidence proves that high anti-Mullerian hormone (AMH) levels may play an important role in follicular development. Long noncoding RNA (lncRNA) with a length of more than 200 nt is widely involved in the directional differentiation, growth, and development of cells, whereas whether lncRNA is involved in AMH's role in follicular development is unknown. Read More

View Article and Full-Text PDF

Evaluation of CAG repeat length in the androgen receptor gene and polycystic ovary syndrome risk in Iranian women: A case-control study.

Int J Reprod Biomed 2021 Mar 21;20(3):195-202. Epub 2022 Apr 21.

Abortion Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Background: Polycystic ovary syndrome (PCOS) is a heterogeneous disorder, which affects about 15-20% of women of reproductive age. The most important etiopathogenesis factor in its incidence is hyperandrogenism; over 70 candidate genes are known to be associated with this syndrome, such as the androgen receptor () gene which encodes a steroid receptor and is located on the Xq11-12 chromosome. The N-terminus of exon 1 of contains a polymorphic trinucleotide repeat (CAG) region that encodes glutamine tract. Read More

View Article and Full-Text PDF

Changes in serum heavy metals in polycystic ovary syndrome and their association with endocrine, lipid-metabolism, inflammatory characteristics and pregnancy outcomes.

Reprod Toxicol 2022 May 13;111:20-26. Epub 2022 May 13.

Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, P.R. China. Electronic address:

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of reproductive age. Heavy metals, a nonnegligible pollutant, have significant effects on human health, and they are related to reproductive dysfunction. This study aimed to investigate whether serum heavy metal levels were related to PCOS and the association of increased heavy metals with endocrine, lipid-metabolism and inflammatory characteristics and pregnancy outcomes. Read More

View Article and Full-Text PDF

IVF outcome with a high level of AMH: a focus on PCOS versus non-PCOS.

BMC Womens Health 2022 May 14;22(1):172. Epub 2022 May 14.

Division of Reproductive Immunoendocrinology, Department of Obstetrics & Gynecology, Faculty of Medicine, University of Indonesia-Cipto Mangunkusumo National Hospital, Jl. Pangeran Diponegoro No.71, Kenari, Kec. Senen, Kota Jakarta Pusat, Daerah Khusus Ibukota Jakarta, 10430, Indonesia.

Background: The purpose of this research was to investigate whether high AMH levels in PCOS patients resulted in different IVF outcomes compared to those in non-PCOS patients.

Methods: A retrospective cohort study was conducted involving 238 women undergoing IVF who had AMH levels > 4 ng/ml. Participants were divided into two groups: PCOS and non-PCOS. Read More

View Article and Full-Text PDF

'I'm usually being my own doctor': women's experiences of managing polycystic ovary syndrome in Canada.

Int Health 2022 May 14. Epub 2022 May 14.

University of Parakou, Faculty of Medicine, Parakou, Benin.

Background: Polycystic ovary syndrome (PCOS) is a complex, chronic condition characterized by anovulation, polycystic ovarian morphology and hyperandrogenism that requires lifelong management. To reduce the risk of comorbidity and to manage symptoms, lifestyle management and pharmaceuticals such as oral contraceptives are the most common forms of treatment and should be tailored to the individual patient. The literature to date has shown PCOS patients to experience widespread dissatisfaction with the amount and quality of information they receive from providers, along with lower levels of trust in physicians. Read More

View Article and Full-Text PDF

Parameters for Calcium Metabolism in Women with Polycystic Ovary Syndrome Who Undergo Stimulation with Letrozole: A Prospective Cohort Study.

J Clin Med 2022 May 5;11(9). Epub 2022 May 5.

Clinical Division of Gynecologic Endocrinology and Reproductive Medicine, Medical University of Vienna, 1090 Vienna, Austria.

For women with polycystic ovarian syndrome (PCOS) and infertility, stimulation with the aromatase-inhibitor letrozole has been recommended as a first-line for ovulation induction. Calcium-associated signaling has also been a component for other ovulation induction and superovulation medications. This study's aim was to evaluate parameters of calcium metabolism in PCOS women. Read More

View Article and Full-Text PDF

The Activity of Superoxide Dismutase, Its Relationship with the Concentration of Zinc and Copper and the Prevalence of rs2070424 Superoxide Dismutase Gene in Women with Polycystic Ovary Syndrome-Preliminary Study.

J Clin Med 2022 May 1;11(9). Epub 2022 May 1.

Department of Endocrinological Gynecology, Medical University of Silesia, 40-752 Katowice, Poland.

Superoxide dismutase (SOD) is a crucial antioxidant enzyme involved in the antioxidant pathway during both normal cellular metabolism and different pathologic processes. We investigated the activity of the copper (Cu)-zinc (Zn) SOD1 as well as the level of Cu and Zn in the serum of women with polycystic ovary syndrome (PCOS) and control group. Moreover, the prevalence of rs2070424 gene polymorphism of the enzyme in the course of PCOS was evaluated. Read More

View Article and Full-Text PDF

Prepregnancy Polycystic Ovary Syndrome as a Risk Factor of Subsequent Preterm Labor: A National Population-Based Cohort Study.

Int J Environ Res Public Health 2022 Apr 30;19(9). Epub 2022 Apr 30.

Department of Obstetrics and Gynecology, Taipei Tzu-Chi Hospital, Buddhist Tzu-Chi Medical Foundation, Taipei 231, Taiwan.

Background: Preterm labor and the following preterm births, which account for most of the perinatal deaths, are an important issue in public health. The study aims to assess the risk of subsequent preterm labor in pregnant females who have prepregnancy polycystic ovary syndrome (PCOS).

Methods: This study has enrolled 1,000,000 randomly sampled females retrieved from the Taiwan National Health Insurance Research Database (NHIRD) during 1998-2012. Read More

View Article and Full-Text PDF

Non-Cytokine Protein Profile of the Mesenchymal Stem Cell Secretome That Regulates the Androgen Production Pathway.

Int J Mol Sci 2022 Apr 22;23(9). Epub 2022 Apr 22.

Department of Obstetrics and Gynecology, University of Chicago, 5841 S. Maryland Ave., Chicago, IL 60637, USA.

Polycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disorder in reproductive-aged women, and it typically involves elevated androgen levels. Recently, it has been reported that human bone marrow mesenchymal stem cells (hBM-MSCs) can regulate androgen synthesis pathways. However, the details of the mechanism are still unclear. Read More

View Article and Full-Text PDF

The prevalence and phenotypic manifestations of polycystic ovary syndrome (PCOS) among infertile Sudanese women: a cross-sectional study.

BMC Womens Health 2022 May 13;22(1):165. Epub 2022 May 13.

Department of Obstetrics and Gynecology, Unaizah College of Medicine and Medical Sciences, Qassim University, Unaizah, 56219, Saudi Arabia.

Background: Polycystic ovary syndrome (PCOS) is a global health problem associated with significant morbidity during reproductive age. Only a few published studies that address the clinical manifestations and phenotypic presentation of the disease have been conducted in Africa, including Sudan. Thus, this study aimed to evaluate the clinical and biochemical presentation of the different PCOS phenotypes among infertile Sudanese women. Read More

View Article and Full-Text PDF