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    15317 results match your criteria Polycystic Ovarian Syndrome

    1 OF 307

    Understanding polycystic ovary syndrome from the patient perspective: a concept elicitation patient interview study.
    Health Qual Life Outcomes 2017 Aug 18;15(1):162. Epub 2017 Aug 18.
    Quintiles, 8 Skyline Dr, Hawthorne, New York, NY, 10532, USA.
    Background: The aim of this study was to explore the need for a new disease-specific patient reported outcome (PRO) measure for use in clinical trials of drugs designed to target the underlying causes of polycystic ovary syndrome (PCOS), and in the process contribute to our understanding of the symptoms and impacts that define the patient experience with PCOS.

    Methods: Semi-structured interviews were conducted in 20 women diagnosed with PCOS according to the Rotterdam criteria who had not menstruated in the previous month. The relative importance of PCOS symptoms and impact concepts to patients was determined by analyzing the frequency of their expression in the interview transcripts. Read More

    Metformin - a new old drug.
    Endokrynol Pol 2017 ;68(4):482-496
    Department of Internal Medicine, Diabetology and Cardiometabolic Disorders, School of Medicine with the Division of Dentistry in Zabrze,Medical University of Silesia, Zabrze, Poland.
    For many years metformin has been the gold standard in the treatment of type 2 diabetes. According to recommendations of the most important diabetes associations, this is the first-choice drug for use as monotherapy in patients with newly diagnosed type 2 diabetes. Metformin is also recommended in combined treatment when monotherapy is no longer effective. Read More

    Weight and Eating Concerns in Women's Reproductive Health.
    Curr Psychiatry Rep 2017 Aug 18;19(10):68. Epub 2017 Aug 18.
    Perelman School of Medicine at the University of Pennsylvania, 3535 Market Street, 3rd Floor, Philadelphia, PA, USA.
    Purpose Of Review: Women's weight status affects their reproductive functioning, and, likewise, women's lifetime weight trajectories are influenced by reproductive events. We examine the relationship between polycystic ovary syndrome (PCOS), pregnancy, the postpartum period, and gynecological cancers with weight, body image, and other psychiatric issues.

    Recent Findings: Women with overweight or obesity are at higher risk for PCOS, and the mood and anxiety symptoms often comorbid with PCOS are linked to weight as well as the core symptoms of the disorder. Read More

    Combined transcriptome and metabolome analyses of metformin effects reveal novel links between metabolic networks in steroidogenic systems.
    Sci Rep 2017 Aug 17;7(1):8652. Epub 2017 Aug 17.
    Pediatric Endocrinology and Diabetology of the Department of Pediatrics and the Department of Clinical Research, University of Bern, 3010, Bern, Switzerland.
    Metformin is an antidiabetic drug, which inhibits mitochondrial respiratory-chain-complex I and thereby seems to affect the cellular metabolism in many ways. It is also used for the treatment of the polycystic ovary syndrome (PCOS), the most common endocrine disorder in women. In addition, metformin possesses antineoplastic properties. Read More

    Authors' reply re: Inositol treatment of anovulation in women with polycystic ovary syndrome: a meta-analysis of randomised trials.
    BJOG 2017 Aug 16. Epub 2017 Aug 16.
    Women's Health Research Unit, The Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

    Serum complexed and free prostate specific antigen levels are lower in female elite athletes in comparison to control women.
    F1000Res 2017 17;6:1131. Epub 2017 Jul 17.
    Department of Women's and Children's Health, Division of Obstetrics and Gynecology, Karolinska Institutet, Stockholm, Sweden.
    Background: We hypothesize that prostate specific antigen (PSA), a protein that it is under regulation by androgens, may be differentially expressed in female elite athletes in comparison to control women.

    Methods: We conducted a cross-sectional study of 106 female athletes and 114 sedentary age-matched controls.  Serum from these women was analyzed for complexed prostate specific antigen (cPSA) and free prostate specific antigen (fPSA), by fifth generation assays with limits of detection of around 6 and 140 fg/mL, respectively. Read More

    Cardiometabolic Features of Polycystic Ovary Syndrome: Role of Androgens.
    Physiology (Bethesda) 2017 Sep;32(5):357-366
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi.
    Polycystic ovary syndrome (PCOS) is the most common endocrine disorder that affects reproductive-age women. Hyperandrogenemia is present in a significant fraction (~80%) of women with PCOS. Increased prevalence of cardiometabolic risk factors is frequently observed in PCOS women. Read More

    Hepatic Adenoma - A Case Report.
    S D Med 2017 Mar;70(3):105-107
    Department of Surgery, University of South Dakota Sanford School of Medicine.
    Although liver lesions in the young population are relatively rare, clinicians can benefit from being familiar with a subset of common benign liver lesions which include hepatic adenoma, hepatic hemangioma, and focal nodular hyperplasia. This a case report of a 25-year-old Jehovah's Witness female on chronic oral contraception for polycystic ovarian syndrome who presented with progressive right upper quadrant abdominal pain. Ultrasound and MRI findings were consistent with hepatic adenoma. Read More

    Association of Prooxidant-Antioxidant Balance with Clinical and Laboratory Parameters and Its Relation to Different Drug Regimens in Polycystic Ovary Syndrome Women with Normal BMI.
    Indian J Clin Biochem 2017 Jul 31;32(3):315-322. Epub 2016 Aug 31.
    Cellular and Molecular Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran.
    Polycystic ovarian syndrome is one of the most common hormonally leading cause infertility disorders. The effect of oxidant-antioxidant imbalance on disease progression has been studied in many disorders. The present study was aimed to evaluate prooxidant-antioxidant balance (PAB) in patients with polycystic ovarian syndrome compared to healthy subjects. Read More

    The presence of ovarian cysts in a captive Antillean manatee (Trichechus manatus manatus L. 1758).
    BMC Vet Res 2017 Aug 15;13(1):240. Epub 2017 Aug 15.
    Department of Pathology, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, C.K. Norwida 31, 50-375, Wroclaw, Poland.
    Background: Several pathological changes associated with reproductive systems of marine mammals have been reported in primary literature. However, no such records exist regarding ovarian cysts in the Antillean manatee (Trichechus manatus manatus L. 1758). Read More

    Association of polycystic ovary syndrome with metabolic syndrome and gestational diabetes: Aggravated complication of pregnancy.
    Exp Ther Med 2017 Aug 22;14(2):1271-1276. Epub 2017 Jun 22.
    Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, P.R. China.
    Polycystic ovary syndrome (PCOS) affects 5-20% of the reproductive age women globally. PCOS is diagnosed by the presence of hyperandrogenism, oligo-anovulation, and polycystic morphology of at least one ovary. Insulin resistance (IR), hyperinsulinemia and associated metabolic abnormalities including metabolic syndrome play a significant role in the development of PCOS. Read More

    The effect of androgen excess on maternal metabolism, placental function and fetal growth in obese dams.
    Sci Rep 2017 Aug 14;7(1):8066. Epub 2017 Aug 14.
    Department of Physiology and Pharmacology, Karolinska Institutet, 171 77, Stockholm, Sweden.
    Pregnant women with polycystic ovary syndrome (PCOS) are often overweight or obese. To study the effects of maternal androgen excess in obese dams on metabolism, placental function and fetal growth, female C57Bl6J mice were fed a control (CD) or a high fat/high sucrose (HF/HS) diet for 4-10 weeks, and then mated. On gestational day (GD) 15. Read More

    Coronary microvascular dysfunction is not associated with a history of reproductive risk factors in women with angina pectoris-An iPOWER substudy.
    Maturitas 2017 Aug 11. Epub 2017 Aug 11.
    Department of Cardiology, Bispebjerg University Hospital, Bispebjerg Bakke 23, 2400 Copenhagen NV, Denmark.
    Background: Reproductive risk factors such as preeclampsia and recurrent miscarriages have been associated with adverse cardiovascular (CV) events. Underlying coronary microvascular dysfunction (CMD) may be a common denominator.

    Purpose: We investigated whether a history of reproductive risk factors was associated with CMD in women with angina pectoris and no obstructive coronary artery disease (CAD). Read More

    Polycystic ovary morphology: age-based ultrasound criteria.
    Fertil Steril 2017 Aug 11. Epub 2017 Aug 11.
    Reproductive Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts. Electronic address:
    Objective: To determine age-based criteria for polycystic ovary morphology.

    Design: Cross-sectional, case-control design.

    Setting: Outpatient setting. Read More

    Network analysis identifies common genes associated with obesity in six obesity-related diseases.
    J Zhejiang Univ Sci B 2017 Aug.;18(8):727-732
    Department of Biology, Hebei North University, Zhangjiakou 075029, China.
    Obesity has been reported to be associated with many diseases. However, common obesity-induced biological processes have not been evaluated across these diseases. We identified genes associated with obesity and obesity-related diseases, and used them to construct protein‒protein interaction networks. Read More

    Insulin resistance in pregnant women with and without polycystic ovary syndrome, and measures of body composition in offspring at birth and 3 years of age.
    Acta Obstet Gynecol Scand 2017 Aug 14. Epub 2017 Aug 14.
    Department of Endocrinology, Odense University Hospital, Odense.
    Introduction: Polycystic ovary syndrome (PCOS) is associated with obesity and insulin resistance in the non-pregnant state, but little is known about insulin sensitivity in the pregnant state. Our objective was to compare insulin resistance in pregnant women with and without PCOS and explore the impact of PCOS on body composition in offspring at birth and at 3 years of age MATERIAL AND METHODS: A prospective cohort study including 2548 live born singleton mother-child pairs residing in Odense municipality, Denmark, during 2010-2013. Of the 2548 women, 241 (9. Read More

    Early miscarriage rate in lean polycystic ovary syndrome women after euploid embryo transfer - a matched-pair study.
    Reprod Biomed Online 2017 Jul 29. Epub 2017 Jul 29.
    The Centre of Reproductive Medicine, Department of Obstetrics and Gynecology, First Affiliated Hospital of Sun Yat-sen University, and Guangdong Provincial Key Laboratory of Reproductive Medicine, Guangdong, China. Electronic address:
    The early miscarriage rate is reported to be higher in patients with polycystic ovary syndrome (PCOS) compared with non-PCOS patients. However, whether PCOS is an independent risk factor for early miscarriage is still controversial; to what extent embryonic aneuploidy accounts for miscarriages of PCOS is still unknown. In this 1:3 matched-pair study, 67 lean PCOS patients and 201 controls matched for age, body mass index (BMI) and embryo scores undergoing a single euploid blastocyst transfer in vitrified-warmed cycles were analysed. Read More

    How do red and infrared low-level lasers affect folliculogenesis cycle in rat's ovary tissue in comparison with clomiphene under in vivo condition.
    Lasers Med Sci 2017 Aug 11. Epub 2017 Aug 11.
    Department of Medical Physics and Department of Medical Bioengineering, Tabriz University of Medical Sciences, Tabriz, Iran.
    Folliculogenesis is a cycle that produces the majority of oocyte. Any disruption to this cycle leads to ovulation diseases, like polycystic ovarian syndrome (PCOS). Treatments include drugs and surgery; lasers have also been used complementarily. Read More

    Dipeptidyl Peptidase 4 serum activity and concentration are increased in women with polycystic ovary syndrome.
    Clin Endocrinol (Oxf) 2017 Aug 11. Epub 2017 Aug 11.
    Center for Reproductive Medicine and Andrology, Martin Luther University Halle-Wittenberg, Ernst-Grube-Str. 40, 06120, Halle, Germany.
    Objective: Polycystic ovary syndrome (PCOS) is a complex disease, the etiology of which is not well understood. Alterations in potential candidate genes involved in the biosynthesis and metabolism of androgens, folliculogenesis, and insulin and glucose metabolism have been suggested as possible etiologies. Dipeptidyl peptidase-4 (DPP4) plays a key role in glucose homeostasis and, thus, in the regulation of insulin secretion. Read More

    Comparison of neonatal outcomes following progesterone use during ovarian stimulation with frozen-thawed embryo transfer.
    Sci Rep 2017 Aug 10;7(1):7835. Epub 2017 Aug 10.
    Department of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, 639 Zhizaoju Rd., Shanghai, 200000, China.
    Progesterone soft capsules (brand name: Utrogestan) were demonstrated to be an effective oral alternative to prevent premature LH surges both in normal-ovulatory and polycystic ovarian syndrome (PCOS) patients. However, its safety in terms of neonatal outcomes is unclear. To evaluate whether Utrogestan use increase the risk of adverse neonatal outcomes compared with short protocol in patients undergoing IVF/ICSI treatments in combination with frozen-thawed embryo transfer (FET), we performed a retrospective analysis including 1008 FET cycles, with embryos originated from either Utrogestan + hMG protocol (n = 499), or short protocol (n = 509), which led to 546 live-born infants. Read More

    Glycolipid and Hormonal Profiles in Young Men with Early-Onset Androgenetic Alopecia: A meta-analysis.
    Sci Rep 2017 Aug 10;7(1):7801. Epub 2017 Aug 10.
    Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
    Hormonal and metabolic abnormalities have been reported in men with early-onset androgenetic alopecia (AGA). Although this has been ascribed to the existence of a male polycystic ovary syndrome (PCOS)-equivalent, data on this topic are inconsistent and this syndrome has not been already acknowledged. To evaluate if, already before the age of 35 years, any difference occurs in the glycolipid and hormonal profiles and in the body weight in men with AGA compared to age-matched controls, we performed a comprehensive meta-analysis of all the available observational case-control studies of literature, using MEDLINE, Google Schoolar and Scopus databases. Read More

    Clomiphene citrate is associated with favorable cycle characteristics but impaired outcomes of obese women with polycystic ovarian syndrome undergoing ovarian stimulation for in vitro fertilization.
    Medicine (Baltimore) 2017 Aug;96(32):e7540
    Department of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.
    The aim of this study was to explore the effect of clomiphene citrate (CC) on the cycle characteristics and outcomes of obese women with polycystic ovarian syndrome (PCOS) undergoing ovarian stimulation for in vitro fertilization (IVF).This is a retrospective cohort study, and it was conducted at the tertiary-care academic medical center.This study included 174 obese PCOS patients undergoing IVF. Read More

    Vitamin D predictors in polycystic ovary syndrome: A meta-analysis.
    Eur J Clin Invest 2017 Aug 10. Epub 2017 Aug 10.
    Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, Aghia Sophia Children's Hospital, Athens, Greece.
    Background: The aim of this meta-analysis was to examine differences and predictors of serum 25-hydroxyvitamin D concentrations in women with polycystic ovary syndrome (PCOS) compared with non-PCOS controls matched for body mass index.

    Materials And Methods: Three databases were searched (2003-2015) to retrieve studies that evaluated serum 25-hydroxyvitamin D in PCOS women and controls. Meta-regression analysis was performed with anthropometric and metabolic/endocrine parameters as covariates. Read More

    Metformin reduces total microparticles and microparticles-expressing tissue factor in women with polycystic ovary syndrome.
    Arch Gynecol Obstet 2017 Aug 9. Epub 2017 Aug 9.
    Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
    Purpose: The objective of this study was to evaluate the levels of total microparticles (MPs) and microparticles-expressing tissue factor (TFMPs) in women with polycystic ovarian syndrome (PCOS) who use metformin comparing to those who do not take metformin.

    Methods: We quantified total MPs and TFMPs in the plasma of 50 patients with PCOS-13 of these women used metformin (850 mg 2×/day during at least 6 months) and the other 37 did not. For this purpose, the microparticles (MPs) were purified by differential centrifugation of the plasma and, subsequently, by flow cytometry, using annexin-V and CD142 as markers. Read More

    The pathogenesis and treatment of polycystic ovary syndrome: What's new?
    Adv Clin Exp Med 2017 Mar-Apr;26(2):359-367
    Department of Clinical Endocrinology, Medical University of Lodz, Łódź, Poland.
    Polycystic ovary syndrome (PCOS) is currently the leading cause of menstrual complications in women. It is characterized by clinical and/or biochemical hyperandrogenism, ovulation abnormalities and the presence of enlarged and/or polycystic ovaries in ultrasound images (12 or more small bubbles located circumferentially and/or ovarian volume > 10 mL). It is often comorbid with hyperinsulinemia, dyslipidemia, overweight or obesity, and is a risk factor for the development of diabetes and cardiovascular diseases (CVDs). Read More

    History of discovery of polycystic ovary syndrome.
    • Authors:
    Adv Clin Exp Med 2017 May-Jun;26(3):555-558
    Stein and Leventhal are regarded to have been the first investigators of polycystic ovary syndrome (PCOS); however, in 1721 Vallisneri, an Italian scientist, described a married, infertile woman with shiny ovaries with a white surface, and the size of pigeon eggs. It was not until the early 1990s at a National Institute of Health (NIH) sponsored conference on PCOS that formal diagnostic criteria were proposed and afterwards largely utilized. Many scientists tried to explain the pathophysiology of PCOS and many studies were made. Read More

    Low validity of predictive equations for calculating resting energy expenditure in overweight and obese women with polycystic ovary syndrome.
    J Hum Nutr Diet 2017 Aug 8. Epub 2017 Aug 8.
    Department of Nutrition, Nursing School, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
    Background: Predictive equations are the main clinical tools for determining resting energy expenditure (REE). However, their adequate use in overweight and obese individuals is unclear. Thus, we investigated the best predictive equations for estimating REE in overweight and obese women with polycystic ovary syndrome (PCOS). Read More

    Adiponectin protects against development of metabolic disturbances in a PCOS mouse model.
    Proc Natl Acad Sci U S A 2017 Aug 8. Epub 2017 Aug 8.
    Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, 40530 Gothenburg, Sweden.
    Adiponectin, together with adipocyte size, is the strongest factor associated with insulin resistance in women with polycystic ovary syndrome (PCOS). This study investigates the causal relationship between adiponectin levels and metabolic and reproductive functions in PCOS. Prepubertal mice overexpressing adiponectin from adipose tissue (APNtg), adiponectin knockouts (APNko), and their wild-type (WT) littermate mice were continuously exposed to placebo or dihydrotestosterone (DHT) to induce PCOS-like traits. Read More

    Small leucine-rich proteoglycans (SLRPs) in the endometrium of polycystic ovary syndrome women: a pilot study.
    J Ovarian Res 2017 Aug 8;10(1):54. Epub 2017 Aug 8.
    Disciplina de Ginecologia, Departamento de Obstetrícia e Ginecologia, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
    Background: Small leucine-rich proteoglycans (SLRPs) play an important role in tissue homeostasis and cell proliferation since these proteoglycans sequester multiple growth factors. However, the content of SLRPs in the endometrium of polycystic ovary syndrome (PCOS) women is unknown. Our purpose was to test the hypothesis that excessive endometrial proliferation in PCOS may be partly related to abnormalities in SLRPs. Read More

    A novel method to demonstrate that pregnant women with polycystic ovary syndrome hyper-expose their fetus to androgens as a possible stepping stone for the developmental theory of PCOS. A pilot study.
    Reprod Biol Endocrinol 2017 Aug 8;15(1):61. Epub 2017 Aug 8.
    Harrogate & District NHS Foundation Trust, Lancaster Park Road, Harrogate, HG2 7SX, UK.
    Background: Polycystic ovary syndrome (PCOS), whose aetiology is unknown, is predominately a familial syndrome but confirmation of candidate genes has proved elusive. The developmental hypothesis for the origin of PCOS suggests that exposure of the fetus to excess androgens influences imprinting, leading to altered genetic expression in adult life. The aim of this pilot study was to examine whether the female fetus of a mother with PCOS is indeed exposed to excess androgens. Read More

    Importance of inflammatory markers and IL-6 for diagnosis and follow up of patients with type 2 diabetes mellitus.
    Med Glas (Zenica) 2017 Aug;14(2):169-175
    Department for Biochemistry and Clinical Analysis, Faculty of Pharmacy, University of Sarajevo, Bosnia and Herzegovina.
    Aim To analyse the long-term impact of altered metabolism on the level of mediators of inflammatory response in female patients with type 2 diabetes. Methods This study included 97 female patients with type 2 diabetes and 107 female, nondiabetic control subjects, who were recruited at the Clinical Centre University of Sarajevo and the General Hospital Tešanj. The effects of glycaemic control on markers of inflammatory response represented by C-reactive protein (CRP), fibrinogen, leukocytes, sedimentation rate, and cytokine IL-6 were tested. Read More

    Metabolic and endocrine connections of 17-hydroxypregnenolone in polycystic ovary syndrome women.
    Endocr Connect 2017 Aug 7. Epub 2017 Aug 7.
    M Marcia, INSTITUTO TROPICAL DE MEDICINA REPRODUTIVA E MENOPAUSA, Cuiaba, Brazil.
    Objective: To examine the anthropometric, and metabolic connections of 17-hydroxypregnenolone in the normo- and hyperandrogenemic polycystic ovary syndrome phenotypes.

    Material And Methods: This cohort study enrolled 91 normal cycling healthy women, 46 normoandrogenemic and 147 hyperandrogenemic patients with polycystic ovary syndrome (PCOS). Anthropometric, biochemical, and hormonal parameters were properly verified and correlated with 17-hydroxypregnenolone (17-OHPE) concentrations. Read More

    Cardiovascular RiskprofilE - IMaging and gender-specific disOrders (CREw-IMAGO): rationale and design of a multicenter cohort study.
    BMC Womens Health 2017 Aug 7;17(1):60. Epub 2017 Aug 7.
    Department of Radiology, University Medical Center Utrecht, Heidelberglaan 100, 3584, CX, Utrecht, The Netherlands.
    Background: Reproductive disorders, such as polycystic ovary syndrome (PCOS), primary ovarian insufficiency (POI) and hypertensive pregnancy disorders (HPD) like pre-eclampsia (PE), are associated with an increased risk of cardiovascular disease (CVD). Detection of early signs of cardiovascular disease (CVD), as well as identification of risk factors among women of reproductive age which improve cardiovascular risk prediction, is a challenge and current models might underestimate long-term health risks. The aim of this study is to assess cardiovascular disease in patients with a history of a reproductive disorder by low-dose computed tomography (CT). Read More

    Puberty arises with testicular alterations and defective AMH expression in rams prenatally exposed to testosterone.
    Domest Anim Endocrinol 2017 Jun 23;61:100-107. Epub 2017 Jun 23.
    Laboratory of Animal Physiology and Endocrinology (FISENLAB), Faculty of Veterinary Sciences, University of Concepción, Chillán, Chile. Electronic address:
    The male gonadal tissue can be a sensitive target to the reprogramming effects of testosterone (T) during prenatal development. We have demonstrated that male lambs born to dams receiving T during pregnancy-a model system to the polycystic ovary syndrome (PCOS)-show a decreased number of germ cells early in life, and when adult, a reduced amount of sperm and ejaculate volume. These findings are a key to put attention to the male offspring of women bearing PCOS, as they are exposed to increased levels of androgen during pregnancy which can reprogram their reproductive outcome. Read More

    Diabetes risk in women with gestational diabetes mellitus and a history of polycystic ovary syndrome: a retrospective cohort study.
    Diabet Med 2017 Aug 7. Epub 2017 Aug 7.
    Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.
    Aims: To investigate whether polycystic ovary syndrome further increases postpartum diabetes risk in women with gestational diabetes mellitus and to explore relationships between polycystic ovary syndrome and incident diabetes in women who do not develop gestational diabetes.

    Methods: This retrospective cohort study (Quebec Physician Services Claims; Hospitalization Discharge Databases; Birth and Death registries) included 34 686 women with gestational diabetes during pregnancy (live birth), matched 1:1 to women without gestational diabetes by age group, year of delivery and health region. Diagnostic codes were used to define polycystic ovary syndrome and incident diabetes. Read More

    Serum 25-hydroxy vitamin D levels in Turkish adolescent girls with polycystic ovary syndrome and the correlation with clinical/biochemical parameters.
    J Pediatr Adolesc Gynecol 2017 Aug 3. Epub 2017 Aug 3.
    (Department of Reproductive Endocrinology)(,)(Zekai Tahir Burak Women's Health Education and Research Hospital)(,)(Ankara)(,) Turkey.
    Objective: Polycystic ovary syndrome (PCOS) is a common endocrinopathy among the female adolescents and young women. The aim of this study is to investigate the relationship between serum 25-hydroxy vitamin D (serum 25(OH) D) levels and metabolic parameters and other characteristics of the PCOS and non-PCOS adolescents.

    Design: Case-control study. Read More

    Prokineticin 1 is up-regulated by insulin in decidualizing human endometrial stromal cells.
    J Cell Mol Med 2017 Aug 7. Epub 2017 Aug 7.
    Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
    Prokineticin 1 (PROK1), a hypoxia-regulated angiogenic factor, has emerged as a crucial regulator of embryo implantation and placentation. Dysregulation of PROK1 has been linked to recurrent pregnancy loss, pre-eclampsia, foetal growth restriction and preterm birth. These pregnancy complications are common in women with obesity and polycystic ovary syndrome, i. Read More

    Repeated collection of conjoined oocytes from a patient with polycystic ovary syndrome, resulting in one successful live birth from frozen thawed blastocyst transfer: a case report.
    J Assist Reprod Genet 2017 Aug 5. Epub 2017 Aug 5.
    Yano Maternity Clinic, IVF center, Matsuyama, 790-0872, Japan.
    Few cases have been reported in which the aspiration of a single follicle led to the recovery of two conjoined oocytes surrounded by a single zona pellucida. This report describes a successful embryo transfer with subsequent live birth derived from conjoined oocytes, and a later pair of conjoined oocytes in the same patient. After oocyte retrieval from a patient with polycystic ovary syndrome, two pairs of conjoined oocytes were collected. Read More

    Metabolic syndrome in Iranian adolescents with polycystic ovary syndrome.
    Int J Adolesc Med Health 2017 Aug 5. Epub 2017 Aug 5.
    .
    Background Metabolic syndrome (MS) in adolescents is a risk factor for type 2 diabetes and cardiovascular diseases. Objective The present study aimed to determine the prevalence of MS in 14-18-year-old girls. Methods This analytical case-control study was conducted on 3200 high school students with polycystic ovarian syndrome (PCOS). Read More

    Estrogen-gut microbiome axis: Physiological and clinical implications.
    Maturitas 2017 Sep 23;103:45-53. Epub 2017 Jun 23.
    Department of Basic Medical Sciences, College of Medicine-Phoenix, University of Arizona, Phoenix, AZ, USA; Department of Obstetrics and Gynecology, College of Medicine-Phoenix, University of Arizona, Phoenix, AZ, USA. Electronic address:
    Low levels of gonadal circulating estrogen observed in post-menopausal women can adversely impact a diverse range of physiological factors, with clinical implications for brain cognition, gut health, the female reproductive tract and other aspects of women's health. One of the principal regulators of circulating estrogens is the gut microbiome. This review aims to shed light on the role of the gut microbiota in estrogen-modulated disease. Read More

    Increased rates of complications in singleton pregnancies of women previously diagnosed with polycystic ovary syndrome predominantly in the hyperandrogenic phenotype.
    Fertil Steril 2017 Aug;108(2):333-340
    Department of Reproductive Medicine and Gynaecology, University Medical Center Utrecht, Utrecht, the Netherlands; Department of Obstetrics, University Medical Center Utrecht, Utrecht, the Netherlands.
    Objective: To study the presence of several maternal and neonatal complications in a cohort of women with hyperandrogenic as well as normoandrogenic polycystic ovary syndrome (PCOS) and women with PCOS who received different fertility treatments.

    Design: Prospective multicenter cohort study.

    Setting: Hospitals and midwifery practices. Read More

    Exploring factors related to changes in body composition, insulin sensitivity and aerobic capacity in response to a 12-week exercise intervention in overweight and obese women with and without polycystic ovary syndrome.
    PLoS One 2017 3;12(8):e0182412. Epub 2017 Aug 3.
    Department of Medicine - Western Campus and Australian Institute for Musculoskeletal Science, The University of Melbourne, St Albans, Victoria, Australia.
    Objective: To determine factors associated with differential changes in body fat, insulin resistance and aerobic capacity following a 12-week exercise intervention in overweight and obese women with and without polycystic ovary syndrome (PCOS).

    Methods: 16 overweight and obese women (9 PCOS; 7 without PCOS) completed a supervised progressive 12-week exercise program. Primary outcomes included changes in indicators of insulin sensitivity (including glucose infusion rate relative to fat-free mass [GIR/FFM]), body composition, and aerobic capacity (VO2 peak; 12 participants only). Read More

    Metformin therapy for the reproductive and metabolic consequences of polycystic ovary syndrome.
    Diabetologia 2017 Aug 3. Epub 2017 Aug 3.
    Department of Medicine, Section of Adult and Paediatric Endocrinology, Diabetes, and Metabolism, The University of Chicago, 5841 S. Maryland Avenue, MC1027, Chicago, IL, 60637, USA.
    Polycystic ovary syndrome (PCOS), the most common hormonal disorder among women of reproductive age, has various metabolic and reproductive consequences. Metformin was originally shown to lower testosterone levels in women with PCOS in the 1990s, an effect presumably related to its insulin sensitising actions. However, the precise mechanisms of metformin action in PCOS remain unclear and there is considerable heterogeneity in the clinical response to this therapy in women with PCOS. Read More

    Androstenedione and testosterone levels correlate with in vitro fertilization rates in insulin-resistant women.
    BMJ Open Diabetes Res Care 2017 27;5(1):e000387. Epub 2017 May 27.
    Department of Medicine, Weill Cornell Medicine Qatar, Doha, Qatar.
    Background: The free androgen index (FAI) calculated using total testosterone measured by immunoassay does not correlate with oocyte fertilization rates; however, there is considerable cross-reactivity for testosterone with other androgens by immunoassay that is not found using isotope dilution liquid chromatography-tandem mass spectrometry (LC/MS/MS).

    Aims: This study was done to determine relationship between total testosterone and androstenedione measured by LC/MS/MS and fertilization rates.

    Study Design: 49 infertile women without polycystic ovary syndrome were recruited preceding an in vitro fertilization (IVF) cycle. Read More

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