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    Sex hormone binding globulin - an important biomarker for predicting PCOS risk: A systematic review and meta-analysis.
    Syst Biol Reprod Med 2017 Dec 11:1-13. Epub 2017 Dec 11.
    a Centre for Medical Biotechnology, Maharshi Dayanad University , Haryana , India.
    Sex hormone-binding globulin (SHBG) is a glycoprotein which regulates bioavailability of sex steroid hormones. Interest in SHBG has escalated in recent years because of its inverse association with polycystic ovary syndrome (PCOS), obesity, insulin resistance, metabolic syndrome, and diabetes type II. This meta-analysis was performed to examine the associations of SHBG with PCOS and to correlate serum SHBG levels with various PCOS associated endocrine and metabolic dysregulation as well as to determine the effects of various therapeutic agents on serum SHBG levels in PCOS patients in order to assess the true accuracy of SHBG in the prediction of PCOS. Read More

    Analysis of Secreted Peptidome from Omental Adipose Tissue in Polycystic Ovarian Syndrome Patients.
    J Cell Physiol 2017 Dec 11. Epub 2017 Dec 11.
    Nanjing Maternal and Child Health Institute, Nanjing Maternal and Child Health Hospital, Obstetrics and Gynecology Hospital affiliated to Nanjing Medical University, Nanjing, China.
    Polycystic Ovarian Syndrome (PCOS) is a common endocrinopathy associated with increased risk of metabolic disorders. Prevalence of adiposity and obesity is greater in women suffering from PCOS. Moreover, adipose tissue dysfunction has been demonstrated in PCOS patients, particularly in abdominal adipose tissue. Read More

    Authors' reply re: Inositol treatment of anovulation in women with polycystic ovary syndrome: a meta-analysis of randomised trials.
    BJOG 2017 Dec 11. Epub 2017 Dec 11.
    Women's Health Research Unit, The Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

    Regulation of follicle growth through hormonal factors and mechanical cues mediated by Hippo signaling pathway.
    Syst Biol Reprod Med 2017 Dec 9:1-9. Epub 2017 Dec 9.
    a Department of Obstetrics and Gynecology , St. Marianna University School of Medicine , Kawasaki City , Kanagawa , Japan.
    The ovary is an interesting organ that shows major structural changes within a short period of time during each reproductive cycle. Follicle development is controlled by local paracrine and systemic endocrine factors. Many hormonal and molecular analyses have been conducted to find the mechanisms underlying structural changes in ovaries, However, exact mechanisms still remain to be determined. Read More

    The Role of Androgen Excess in Metabolic Dysfunction in Women : Androgen Excess and Female Metabolic Dysfunction.
    Adv Exp Med Biol 2017 ;1043:597-608
    Diabetes Obesity and Human Reproduction Research Group, Department of Endocrinology & Nutrition, Hospital Universitario Ramon y Cajal & Universidad de Alcalá & Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS & Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, Madrid, Spain.
    Polycystic ovary syndrome (PCOS) is characterized by the association of androgen excess with chronic oligoovulation and/or polycystic ovarian morphology, yet metabolic disorders and classic and nonclassic cardiovascular risk factors cluster in these women from very early in life. This chapter focuses on the mechanisms underlying the association of PCOS with metabolic dysfunction, focusing on the role of androgen excess on the development of visceral adiposity and adipose tissue dysfunction. Read More

    Prenatal Testosterone Programming of Insulin Resistance in the Female Sheep.
    Adv Exp Med Biol 2017 ;1043:575-596
    Department of Pediatrics, University of Michigan, Ann Arbor, MI, USA.
    Insulin resistance, a common feature of metabolic disorders such as obesity, nonalcoholic fatty liver disease, metabolic syndrome, and polycystic ovary syndrome, is a risk factor for development of diabetes. Because sex hormones orchestrate the establishment of sex-specific behavioral, reproductive, and metabolic differences, a role for them in the developmental origin of insulin resistance is also to be expected. Female sheep exposed to male levels of testosterone during fetal life serve as an excellent translational model for delineating programming of insulin resistance. Read More

    Sex Differences in Androgen Regulation of Metabolism in Nonhuman Primates.
    Adv Exp Med Biol 2017 ;1043:559-574
    Division of Cardiometabolic Health, Oregon National Primate Research Center, Oregon Health & Science University, Portland, OR, USA.
    The in-depth characterization of sex differences relevant to human physiology requires the judicious use of a variety of animal models and human clinical data. Nonhuman primates (NHPs) represent an important experimental system that bridges rodent studies and clinical investigations. NHP studies have been especially useful in understanding the role of sex hormones in development and metabolism and also allow the elucidation of the effects of pertinent dietary influences on physiology pertinent to disease states such as obesity and diabetes. Read More

    The prevalence of polycystic ovary syndrome in reproductive-aged women of different ethnicity: a systematic review and meta-analysis.
    Oncotarget 2017 Nov 12;8(56):96351-96358. Epub 2017 Jul 12.
    Department of Statistical Science, University College London, London, United Kingdom.
    The prevalence of PCOS was investigated in many studies in different continents. However, there is no established prevalence of PCOS for distinct ethnic groups. In the current analysis, we conducted searches in PubMed, The Cochrane Library, EMBASE, CINAHL up to Jan. Read More

    Impaired Lipolysis, Diminished Fat Oxidation and Metabolic Inflexibility in Obese Girls with Polycystic Ovary Syndrome.
    J Clin Endocrinol Metab 2017 Dec 6. Epub 2017 Dec 6.
    Center for Pediatric Research in Obesity and Metabolism, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
    Context: Metabolic flexibility reflects the ability to switch from lipid to carbohydrate oxidation during insulin stimulation manifested in increased respiratory quotient (RQ). Despite insulin resistance in glucose metabolism in PCOS women and adolescents, little is known about adipose tissue metabolism and metabolic flexibility.

    Objective: To investigate whole-body lipolysis, substrate oxidation and metabolic flexibility in obese PCOS vs. Read More

    Ovarian Morphology by Transabdominal Ultrasound Correlates With Reproductive and Metabolic Disturbance in Adolescents With PCOS.
    J Adolesc Health 2017 Dec 5. Epub 2017 Dec 5.
    Department of Endocrinology, Children's Mercy Hospital, Kansas City, Missouri. Electronic address:
    Purpose: To determine whether ovarian morphology imaged using transabdominal ultrasonography reflects clinical and metabolic features in adolescents with polycystic ovary syndrome (PCOS).

    Methods: A retrospective pilot study was conducted in 33 adolescents (12-18 years) with PCOS as defined by hyperandrogenism and irregular cycles. Adolescents underwent the following assessments at a random time during the menstrual cycle: transabdominal ultrasonography, physical examination (height, weight, and systolic and diastolic blood pressure), fasting hormonal tests (free, percent free, and total testosterone, androstenedione, follicle stimulating hormone, luteinizing hormone), and metabolic tests (including an oral glucose tolerance test, fasting and 2-hour insulin and glucose, homeostatic model assessment of insulin resistance, and whole-body insulin sensitivity index). Read More

    Circulating irisin in patients with polycystic ovary syndrome: a meta-analysis.
    Reprod Biomed Online 2017 Nov 22. Epub 2017 Nov 22.
    Division of Sports and Rehabilitation Medicine, Ulm University Medical Centre, Ulm, Germany.
    There is growing interest in exploring circulating (plasma/serum) irisin in polycystic ovary syndrome (PCOS) patients. This meta-analysis aimed to summarize the evidence assessing circulating irisin changes in this population. A systematic search was conducted in three databases: PubMed, Cochrane Library and Web of Science, for studies reporting irisin in PCOS patients compared with healthy controls or stratified by body mass index (BMI), or assessing irisin response to hyperinsulinemia. Read More

    Risks, benefits size and clinical implications of combined oral contraceptive use in women with polycystic ovary syndrome.
    Reprod Biol Endocrinol 2017 Dec 8;15(1):93. Epub 2017 Dec 8.
    Department of Gynecology and Obstetrics, Medical School, Federal University of Mato Grosso, Cuiabá, MT, 78055-728, Brazil.
    Background: Polycystic ovary syndrome (PCOS) is a complex condition with high risk for dyslipidemia, dysglycemia, venous thromboembolism, cardiovascular disease and metabolic syndrome. Because the combined oral contraceptive (COC) use has also been associated with impaired fasting glucose, insulin resistance and increased risk of thromboembolism disease, it is rationale to think that the combination of oral contraceptive and PCOS could make it worse or increase the risks.

    Objective: To examine the current data regarding potential additional risks and benefits of contraceptive use, highlights the major gap in knowledge for designing future studies and, when possible, suggests an adequate COC formulation for a determined PCOS phenotype. Read More

    Clomiphene Stair-Step Protocol for Women With Polycystic Ovary Syndrome.
    Obstet Gynecol 2017 Dec 4. Epub 2017 Dec 4.
    Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, California.
    Objective: To compare time to ovulation, ovulation rates, and side effect profile of traditional and the stair-step protocol for ovulation induction using clomiphene citrate in women with polycystic ovary syndrome (PCOS).

    Methods: We performed a retrospective study of women seeking care for infertility with a diagnosis of PCOS at a university-based infertility clinic from July 2012 to July 2014. We included patients who were resistant to the initial starting dose of 50 mg clomiphene. Read More

    Pregnancy outcomes in women on metformin for diabetes or other indications among those seeking teratology information services.
    Br J Clin Pharmacol 2017 Dec 7. Epub 2017 Dec 7.
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts.
    Background: Metformin is used to treat type 2 diabetes, polycystic ovary syndrome associated infertility, and gestational diabetes. Human studies evaluating the safety of metformin in early pregnancy are scarce.

    Method: We evaluated the risk of major birth defects and pregnancy losses in a cohort of pregnant women exposed to metformin during first trimester for different indications relative to a matched unexposed reference group. Read More

    Combined Oral Contraception and Bicalutamide in Polycystic Ovary Syndrome and Severe Hirsutism - a Double-blind RTC.
    J Clin Endocrinol Metab 2017 Dec 1. Epub 2017 Dec 1.
    Department of Experimental Medicine, Unit of Endocrinology, "Policlinico Umberto I" Hospital, University of Rome La Sapienza, Rome, Italy.
    Background: Hirsutism is frequently expressed in women affected by polycystic ovary syndrome (PCOS). The efficacy of oral contraceptive pill (OC) plus anti-androgens in the treatment of its severe expression is controversial due to the lack of randomized double-blind long-term studies.

    Aim: The primary outcome was the reduction of hirsutism in PCOS women objectively measured by videodermoscopy (VD) on the androgen-sensitive skin areas assessed by the modified Ferriman&Gallwey (mF&G) total score, after 12 months of therapy with OC+Bicalutamide (BC) versus OC plus placebo (P). Read More

    Incidence and burden of gynecologic disorders, active component service women, U.S. Armed Forces, 2012-2016.
    MSMR 2017 11;24(11):30-38
    This report describes the incidence, burden, and co-occurrence of four common gynecologic disorders among active component service women during 2012-2016. Overall incidence rates were highest for menorrhagia (100.9 per 10,000 person-years [p-yrs]), followed by uterine fibroids (63. Read More

    Molecular Modifiers of Hormone Receptor Action: Decreased Androgen Receptor Expression in Mismatch Repair Deficient Endometrial Endometrioid Adenocarcinoma.
    Int J Gynecol Pathol 2017 Nov 28. Epub 2017 Nov 28.
    Department of Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas.
    Endometrial endometrioid carcinoma is related to estrogen excess and expression of estrogen and progesterone receptors. Epidemiological evidence suggests that exposure to elevated androgens, as in polycystic ovarian syndrome, increases the risk of endometrial cancer. Factors impacting androgen receptor (AR) expression are not well studied. Read More

    Uterine function: from normal to Polycystic Ovarian Syndrome alterations.
    Curr Med Chem 2017 Dec 5. Epub 2017 Dec 5.
    Laboratory of Ovarian Physio-pathology, Center of Pharmacological and Botanical Studies, School of Medicine,University of Buenos Aires. Argentina.
    Background: The endometrium is one of the most important female reproductive organs. Polycystic ovarian syndrome (PCOS) is a reproductive and endocrine pathology that affect women of reproductive age. PCOS negatively affects the endometrium, leading to implantation failure and proliferative aberrations. Read More

    Early Clinical Expressions of Insulin Resistance: The Real Enemy to Look For.
    Diabetes Ther 2017 Dec 5. Epub 2017 Dec 5.
    Endocrinology Division, Department of Internal Medicine, University Hospital, Universidad Autonoma de Nuevo Leon, Monterrey, 64460, Mexico.
    The type 2 diabetes mellitus epidemic threatens public healthcare systems worldwide. Efforts to prevent chronic complications of diabetes and reduce their associated mortality have been ineffective. Hence, early prevention of type 2 diabetes mellitus and cardiovascular disease needs to be prioritized. Read More

    The overlap between Binge Eating Behaviors and Polycystic Ovarian Syndrome: An etiological integrative model.
    Curr Pharm Des 2017 Dec 4. Epub 2017 Dec 4.
    Faculty of Health, University of Melbourne, Melbourne. Australia.
    Studies indicate that Polycystic Ovarian Syndrome (PCOS) features (e.g. insulin instability, food cravings, overproduction of androgens and menstrual irregularities) associate with increased appetite, impaired impulse control and feelings of body dissatisfaction. Read More

    Reproductive disturbances among Saudi adolescent girls and young women with type 1 diabetes mellitus.
    World J Diabetes 2017 Nov;8(11):475-483
    Department of Endocrinology and Diabetes, Diabetes Treatment Center, Prince Sultan Military Medical City, Riyadh 11159, Saudi Arabia.
    Aim: To identify reproductive disturbances among adolescent girls and young women with type 1 diabetes mellitus (T1DM) in Saudi Arabia.

    Methods: This cross sectional study was conducted among 102 female with T1DM, (aged 13-29 years) who attended the Diabetes Clinic at Diabetes Treatment Center, Prince Sultan Military Medical City, Saudi Arabia between April 2015 to March 2016. Clinical history, anthropometric characteristics and reproductive disturbance were collected through a questionnaire. Read More

    Abnormal CFTR Affects Glucagon Production by Islet α Cells in Cystic Fibrosis and Polycystic Ovarian Syndrome.
    Front Physiol 2017 17;8:835. Epub 2017 Nov 17.
    Epithelial Cell Biology Research Centre, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong.
    Glucagon, produced by islet α cells, functions to increase blood glucose. Abnormal glucose levels are often seen in cystic fibrosis (CF), a systematic disease caused by mutations of the CF transmembrane conductance regulator (CFTR), and in polycystic ovarian syndrome (PCOS), an endocrine disorder featured with hyperandrogenism affecting 5-10% women of reproductive age. Here, we explored the role of CFTR in glucagon production in α cells and its possible contribution to glucagon disturbance in CF and PCOS. Read More

    Polycystic ovary syndrome is a risk factor for diabetes and prediabetes in middle-aged but not elderly women: a long-term population-based follow-up study.
    Fertil Steril 2017 Dec;108(6):1078-1084
    Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Objective: To study the incidence rate and hazard ratios of diabetes and prediabetes between women with PCOS and healthy subjects.

    Design: Prospective population-based study.

    Setting: Not applicable. Read More

    Prevalence of polycystic ovary syndrome in Thai University adolescents.
    Gynecol Endocrinol 2017 Dec 4:1-5. Epub 2017 Dec 4.
    b Department of Obstetrics & Gynecology, Reproductive Endocrinology and Infertility Unit, Faculty of Medicine , Ramathibodi Hospital, Mahidol University , Bangkok , Thailand.
    Polycystic ovarian syndrome (PCOS) is a common and complex condition characterized by endocrine features and influenced by genetic and environmental factors. In Southeast Asia and Thailand, the prevalence of PCOS is unknown. The aim of this study was to estimate the prevalence of and determine factors associated with PCOS in Thai adolescents. Read More

    Differential Effects on Haemostatic Markers by Metformin and the Contraceptive Pill: A Randomized Comparative Trial in PCOS.
    Thromb Haemost 2017 Nov 30;117(11):2053-2062. Epub 2017 Nov 30.
    Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Clayton, Victoria, Australia.
    Background Polycystic ovarian syndrome (PCOS) affects up to 18% of reproductive-aged women with increased risks of cardiovascular disease and venous thromboembolic disease, related to metabolic and hormonal features, obesity and an apparent hypofibrinolytic state, possibly exacerbated by current PCOS treatments. Objective To investigate and compare haemostatic impacts of common pharmacological treatments and explore relationships with hormonal and metabolic variables in PCOS. Patients/Methods This mechanistic sub-study using biobanked samples from a 6-month randomized comparative trial of pharmacological treatments assessed pro- and anti-thrombotic markers and overall haemostatic activity. Read More

    Evaluation of vitamin D status and its correlation with oxidative stress markers in women with polycystic ovary syndrome.
    Int J Reprod Biomed (Yazd) 2017 Jun;15(6):345-350
    Fatemeh Zahra Infertility and Reproductive Health Research Center, Babol University of Medical Sciences, Babol, Iran.
    Background: There is little evidence about antioxidant properties of vitamin D. Recent studies suggest that oxidative stress may play a major role in the pathophysiology of polycystic ovary syndrome (PCOS), but the association of vitamin D with oxidative stress is still not known in PCOS.

    Objective: The goal of the present study was to evaluate the correlation between serum 25-hydroxy vitamin D and oxidative stress markers in PCOS group compared to control group. Read More

    The Effect of Curcumin on TNF-α, IL-6 and CRP Expression in a Model of Polycystic Ovary Syndrome as an Inflammation State.
    J Reprod Infertil 2017 Oct-Dec;18(4):352-360
    Department of Cell and Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran.
    Background: Having low-grade chronic inflammation such as elevated C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) plays a crucial role in polycystic ovary syndrome (PCOS). This study aimed at investigating the therapeutic effects of curcumin on IL-6, CRP and TNF-α and symptoms of polycystic ovary syndrome.

    Methods: In this research, 72 female adult Wistar rats were divided into control (n=12), PCOS (n=12) and curcumin-treated PCOS groups (n=48). Read More

    The Role of Kisspeptin in Female Reproduction.
    Int J Endocrinol Metab 2017 Jul 22;15(3):e44337. Epub 2017 Apr 22.
    Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
    Context: Kisspeptin (KISS1), a recently discovered neuropeptide that acts upstream of gonadotropin-releasing hormone (GnRH) neurons, is critical for maturation and function of the reproductive axis. This review aimed at providing comprehensive and up-to-date information on Kisspeptin and its role in female reproduction.

    Evidence Acquisition: A literature review was performed using PubMed for all English language articles published between 1999 and 2016. Read More

    High-fat diet exposure from pre-pubertal age induces PCOS in rats.
    Reproduction 2017 Dec 1. Epub 2017 Dec 1.
    G Shah, Department of Pharmacology, L.M. College of Pharmacy, Gandhinagar, India.
    Polycystic ovary syndrome (PCOS) is associated with hyperandrogenism, oligo-anovulation, polycystic ovaries and metabolic syndrome. Many researchers reported that PCOS often starts with menarche in adolescents. Presently available animal models focuses on ovarian but not metabolic features of PCOS. Read More

    Identification of microRNAs and genes associated with hyperandrogenism in the follicular fluid of women with polycystic ovary syndrome.
    J Cell Biochem 2017 Nov 28. Epub 2017 Nov 28.
    Nanjing Maternal and Child Health Institute, Nanjing Maternal and Child Health Hospital, Obstetrics and Gynecology Hospital affiliated to Nanjing Medical University, Nanjing, China.
    Background: Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disease, which is characterized by hyperandrogenism (HA), chronic anovulation, polycystic ovaries, insulin resistance and obesity. At present, the mechanism by which PCOS/HA occurs has not been fully elucidated, thus, the mechanisms behind and interventions for HA in PCOS are current hot topics in research. MiRNAs have recently been shown to serve as diagnostic or prognostic biomarkers in patients with cancer. Read More

    Effects of vitamin D on ovary in DHEA-treated PCOS rat model: A light and electron microscopic study.
    Ultrastruct Pathol 2017 Dec 1:1-10. Epub 2017 Dec 1.
    a Department of Histology and Embryology, Faculty of Medicine , Cukurova University , Adana , Turkey.
    Aim: The aim of this study was to investigate the effects of vitamin D treatment on ovary in experimentally designed polycystic ovary syndrome of female rats using light and electron microscopic techniques.

    Methods: Twenty-four female pre-pubertal rats were divided into control, DHEA and DHEA+Vit.D groups. Read More

    Increased serum neuregulin 4 levels in women with polycystic ovary syndrome: A case-control study.
    Ginekol Pol 2017 ;88(10):517-522
    Bursa Yüksek İhtisas Training and Researh Hospital Department of Obstetrics and Gynecology.
    Neuregulin 4 (NRG4) is an adipokine that is synthesized in many tissues and has been shown to be associated with the development of obesity and metabolic disorders in animals and humans. The aim of this study is to investigate the relationship between serum NRG4 levels and various metabolic parameters in women with PCOS. This cross-sectional study included 40 women with PCOS and 40 age- and BMI-matched controls without PCOS. Read More

    The association between the environmental endocrine disruptor bisphenol A and polycystic ovary syndrome: a systematic review and meta-analysis.
    Gynecol Endocrinol 2017 Nov 30:1-8. Epub 2017 Nov 30.
    f Department of Evidence based Medicine and Clinical Epidemiology , West China Hospital, Sichuan University , Chengdu , China.
    Objective: To investigate the association between bisphenol A (BPA) and polycystic ovary syndrome (PCOS).

    Methods: A systematic review and meta-analysis using STATA software for observational studies.

    Results: Nine studies involving 493 PCOS patients and 440 controls were included in this review. Read More

    Chronic hyperandrogenemia in the presence and absence of a western-style diet impairs ovarian and uterine structure/function in young adult rhesus monkeys.
    Hum Reprod 2017 Nov 28:1-12. Epub 2017 Nov 28.
    Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
    Study Question: Does chronic hyperandrogenemia beginning at menarche, in the absence and presence of a western-style diet (WSD), alter ovarian and uterine structure-function in young adult rhesus monkeys?

    Summary Answer: Phenotypic alterations in ovarian and uterine structure/function were induced by exogenous testosterone (T), and compounded in the presence of a WSD (T+WSD).

    What Is Known Already: Hyperandrogenemia is a well-established component of PCOS and is observed in adolescent girls, indicating a potential pubertal onset of disease symptoms. Obesity is often associated with hyperandrogenemia and it is hypothesized that metabolic dysfunction exacerbates PCOS symptoms. Read More

    [Pregnancy complications among women with polycystic ovary syndrome in China: a Meta-analysis].
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 2017 Nov;42(11):1300-1310
    Information Institute, Deyang Center for Disease Control and Prevention, Deyang Sichuan 618000, China.
    Objective: To estimate the status of pregnancy complications among women with polycystic ovary syndrome (PCOS) through a systematic review of published literatures.
 Methods: Systematic literature searches were conducted in PubMed, Web of Science, Medline, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang, Weipu and China Biology Medicine disc (CBMdisc), as well as the relevant articles published from inception to April 1st 2017, which reported the prevalence of pregnancy complications among women with PCOS. Random effective models were used to calculate pooled prevalence and 95% confidence intervals. Read More

    Does myo-inositol oxygenase, the only enzyme to catalyze myo-inositol in vivo, play a role in the etiology of polycystic ovarian syndrome?
    Gynecol Endocrinol 2017 Nov 29:1-4. Epub 2017 Nov 29.
    a Department of Clinical Biochemistry, Faculty of Medicine , Erzincan University , Erzincan , Turkey.
    In polycystic ovary syndrome (PCOS), myo-inositol (MI) supplements have shown many beneficial effects. In this study, therefore, we aimed to investigate the serum level of myo-inositol oxygenase (MIOX), which is the only enzyme catalyzing MI in vivo, in patients with PCOS. Serum MIOX enzyme levels and other laboratory parameters were compared between sixty patients, who were diagnosed with PCOS for the first time, and sixty healthy individuals at similar age and sex. Read More

    Effect of Two Different Doses of Vitamin D Supplementation on Metabolic Profiles of Insulin-Resistant Patients with Polycystic Ovary Syndrome.
    Nutrients 2017 11 24;9(12). Epub 2017 Nov 24.
    Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan 8715988141, Iran
    This study was carried out to evaluate the effects of vitamin D supplementation on the metabolic profiles of insulin-resistant subjects with polycystic ovary syndrome (PCOS). This randomized double-blind, placebo-controlled trial was conducted on 90 insulin-resistant women with PCOS. Participants were randomly assigned to three groups to intake either 4000 IU of vitamin D or 1000 IU of vitamin D or placebo (n = 30 each group) daily for 12 weeks. Read More

    Metabolic syndrome in children and adolescents.
    Transl Pediatr 2017 Oct;6(4):397-407
    Division of Pediatric Endocrinology and Diabetes, University of Utah, Salt Lake City, UT, USA.
    Prevalence of metabolic syndrome in children and adolescents is increasing, in parallel with the increasing trends in obesity rates. Varying definitions of this syndrome have hindered the development of a consensus for the diagnostic criteria in the pediatric population. While pathogenesis of metabolic syndrome is not completely understood, insulin resistance and subsequent inflammation are thought to be among its main mechanistic underpinnings. Read More

    Dermatologic manifestations of endocrine disorders.
    Transl Pediatr 2017 Oct;6(4):300-312
    The Ohio State University College of Medicine, Columbus, OH, USA.
    The skin serves as a window for clinicians to understand, diagnose, and monitor endocrine disease. Dermatologic manifestations of endocrinopathies contribute significantly to an individual's health and quality of life. In this review, we outline various disorders of the hypothalamic-pituitary axis, thyroid gland, pancreas, adrenal gland, and androgen axis as well as hereditary endocrine syndromes. Read More

    Polycystic ovary syndrome in adolescence: diagnostic and therapeutic strategies.
    Transl Pediatr 2017 Oct;6(4):248-255
    Section of Endocrinology, Department of Pediatrics, Nationwide Children's Hospital, the Ohio State University College of Medicine, Columbus, OH, USA.
    Controversy continues about the underlying etiopathogenesis, diagnostic criteria, and recommendations for polycystic ovary syndrome (PCOS) in adolescents. Recent literature has recognized these deficiencies and evidence based expert recommendations have become more available. The purpose of this chapter is to offer primary care providers a practical understanding and approach to the diagnosis and treatment of PCOS in adolescents. Read More

    Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility.
    Cochrane Database Syst Rev 2017 11 29;11:CD003053. Epub 2017 Nov 29.
    Department of Obstetrics and Gynaecology, The General Infirmary of Leeds, United Leeds Teaching Hospitals NHS Trust, Belmont Grove, Leeds, UK, LS2 9NS.
    Background: Polycystic ovary syndrome (PCOS) is characterised by infrequent or absent ovulation, and high levels of androgens and insulin (hyperinsulinaemia). Hyperinsulinaemia occurs secondary to insulin resistance and is associated with increased risk of cardiovascular disease and diabetes mellitus. Insulin-sensitising agents such as metformin may be effective in treating PCOS-related anovulation. Read More

    Health-related knowledge, beliefs and self-efficacy in women with polycystic ovary syndrome.
    Hum Reprod 2017 Nov 22:1-10. Epub 2017 Nov 22.
    Division of Nutritional Sciences, Cornell University, 244 Garden Ave, Ithaca, NY 14853, USA.
    Study Question: Do health-related knowledge, beliefs and self-efficacy differ between women with and without polycystic ovary syndrome (PCOS)?

    Summary Answer: Women with PCOS felt at greater risk for adverse health outcomes, yet believed a healthy lifestyle was less beneficial to prevent weight gain relative to a comparison group.

    What Is Known Already: Diet and physical activity are often used to treat PCOS, but there are high attrition rates and less engagement in self-help methods. It is unclear whether there are unique psychosocial considerations in PCOS that should be incorporated into these interventions. Read More

    [Epigenetics of polycystic ovary syndrome].
    Rev Med Chil 2017 Jul;145(7):907-915
    Departamento de Nutrición. Facultad de Medicina, Laboratorio de Nutrigenómica, Universidad de Chile, Santiago, Chile.
    Polycystic ovarian syndrome (PCOS) is an endocrine and metabolic dysfunction, highly prevalent in women in their reproductive years. Hyperandrogenism, oligo-ovulation, polycystic ovarian morphology are the main features of this syndrome. PCOS is a genetic disorder with a multifactorial etiology and has a strong link with environmental components. Read More

    Nutritional supplements and herbal medicines for women with polycystic ovary syndrome; a systematic review and meta-analysis.
    BMC Complement Altern Med 2017 Nov 25;17(1):500. Epub 2017 Nov 25.
    National Institute of Complementary Medicine, Western Sydney University, Locked Bag 1797, Penrith, NSW, 2751, Australia.
    Background: Polycystic ovary syndrome (PCOS) is a common, reproductive endocrinopathy associated with serious short and long term health risks. Many women with PCOS use ingestible complementary medicines. This systematic review examined the effect on menstrual regulation and adverse effects from randomised controlled trials. Read More

    Association of leptin and insulin resistance in PCOS: A case-controlled study.
    Int J Reprod Biomed (Yazd) 2017 Jul;15(7):423-428
    Department of Obstetrics and Gynecology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
    Background: Endocrine abnormalities related to polycystic ovary Syndrome (PCOS) are important problems.

    Objective: To compare serum leptin levels between infertile women with and without PCOS. To rank sensitivity of six indirect methods for detection of insulin resistance (IR) and to evaluate the association between leptin and IR in PCOS group. Read More

    Polycystic ovary syndrome and circulating inflammatory markers.
    Int J Reprod Biomed (Yazd) 2017 Jun;15(6):375-382
    Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran.
    Background: Human and experimental studies suggest that the sympathetic regulatory drive in the ovary may be unbalanced (hyperactivity) in polycystic ovary syndrome (PCOS). Dysfunctional secretion of interleukin (IL) -1 (α & β) or related cytokines may thus be related to abnormal ovulation and luteinization.

    Objective: The aim of this study was the evaluation of cytokines' pattern in PCOS women and discussion about the explanation of cross-talk between two super systems: sympathetic and immune systems and explanation sympatho-excitation and relationship with interleukins. Read More

    Platelets are involved in in vitro swine granulosa cell luteinization and angiogenesis.
    Anim Reprod Sci 2017 Nov 10. Epub 2017 Nov 10.
    Dipartimento di Scienze Medico-Veterinarie, Università degli Studi di Parma, Via del Taglio 10, 43126 Parma, Italy.
    During corpus luteum formation, impressive biological events take place to guarantee the transition from original follicular to luteal cells and to support required massive angiogenesis. It has been demonstrated that these phenomena resemble those essential for wound healing. After ovulation, blood vessels release their content in the antral cavity and coagulation takes place. Read More

    Effect of orlistat or metformin in overweight and obese polycystic ovary syndrome patients with insulin resistance.
    Gynecol Endocrinol 2017 Nov 24:1-5. Epub 2017 Nov 24.
    a Department of Gynecological Endocrinology Beijing Obstetrics and Gynecology Hospital , Capital Medical University , Beijing , China.
    The aim of this study was to evaluate the effect of orlistat or metformin combined with Diane-35 on anthropometric, hormonal and metabolic parameters in overweight and obese polycystic ovary syndrome (PCOS) patients with insulin resistance (fasting insulin > 10 mIU/L). A total of 240 PCOS women were randomly allocated to orlistat plus Diane-35(OD group), metformin plus Diane-35(MD group), orlistat plus metformin plus Diane-35(OMD group) or Diane-35 (D group). Body weight, BMI, waist and hip circumference, blood pressure, endocrine profile, lipid profile and insulin resistance were assessed at baseline and after 3 months. Read More

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