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    Weight Loss and Improvement in Comorbidity: Differences at 5%, 10%, 15%, and Over.
    Curr Obes Rep 2017 Apr 28. Epub 2017 Apr 28.
    Department of Obstetrics and Gynecology, LSU School of Medicine, 1542 Tulane Avenue, New Orleans, LA, USA.
    Purpose Of Review: One begins to see improvement in glycemic measures and triglycerides with small amounts of weight loss, but with greater levels of weight loss there is even greater improvement. In fact, the relationship between weight loss and glycemia is one that is very close.

    Recent Findings: This is fortunate for diabetes prevention; it takes only small amounts of weight loss to prevent progression to type 2 diabetes from impaired glucose tolerance, and after the 10 kg of weight loss, one cannot demonstrate much additional improvement in risk reduction. Read More

    Sexual Function in Infertile Women with Polycystic Ovary Syndrome and Unexplained Infertility.
    Am J Obstet Gynecol 2017 Apr 25. Epub 2017 Apr 25.
    Department of Biostatistics, Yale University School of Public Health, New Haven, CT.
    Background: While female sexual dysfunction is a frequent occurrence, characteristics in infertile women are not well delineated. Furthermore, the impact of infertility etiology on the characteristics in women with differing androgen levels observed in women with polycystic ovary syndrome and unexplained infertility has not been assessed.

    Objective: To determine the characteristics of sexual dysfunction in women with polycystic ovary syndrome and unexplained infertility. Read More

    Endometrial flushing αVβ3 integrin, glycodelin and PGF2α levels for evaluating endometrial receptivity in women with polycystic ovary syndrome, myoma uteri and endometrioma.
    Gynecol Endocrinol 2017 Apr 28:1-5. Epub 2017 Apr 28.
    a Department of Obstetrics and Gynecology , Faculty of Medicine, Izmir Katip Celebi University , İzmir , Turkey.
    The aim of this cross-sectional study is to compare endometrial flushing fluid levels of αVβ3 integrin, glycodelin and PGF2α during the midluteal phase of the menstrual cycle of women with polycystic ovary syndrome (PCOS, n = 20), myoma uteri (n = 20) and endometrioma (n = 19) with the healthy controls (n = 20). After collecting samples at the midluteal phase of ovulatory volunteers and storing them at -80 °C, αVβ3 integrin, glycodelin and PGF2α levels were analyzed using ELISA. The mean ages of the groups were 28. Read More

    Phenotypic variation in anti-Mullerian hormone (AMH) production per follicle in women with polycystic ovary syndrome (PCOS) and isolated polycystic ovarian morphology (PCOM): an observational cross-sectional study.
    Gynecol Endocrinol 2017 Apr 28:1-6. Epub 2017 Apr 28.
    a Homerton Fertility Centre , Homerton University Hospital , London , United Kingdom.
    This observational study compares the ratio of serum anti-Mullerian hormone (AMH) to the total antral follicle count (AFC) (as a marker of AMH production per follicle) in the various phenotypes of women with polycystic ovary syndrome (PCOS) and isolated polycystic ovarian morphology (PCOM). Two hundred and sixty-two women were recruited. Women with PCOS were divided into four phenotypes based on the diagnostic inclusion criteria of oligo-anovulation (OA), hyperandrogenism (HA) and polycystic ovarian morphology (PCOM). Read More

    Extension of the clomiphene citrate stair-step protocol to gonadotropin treatment in women with clomiphene resistant polycystic ovarian syndrome.
    Gynecol Endocrinol 2017 Apr 28:1-4. Epub 2017 Apr 28.
    a IVF Unit, Department of Obstetrics and Gynecology, Edith Wolfson Medical Center , Holon , Israel.
    Our objective was to evaluate the safety and efficacy of direct initiation of gonadotropin ovarian stimulation without prior withdrawal bleeding in anovulatory clomiphene citrate (CC) resistant polycystic ovarian syndrome (PCOS) patients. Eighteen PCOS patients underwent ovulation induction with CC using a stair-step regimen. Patients who failed to respond to the maximal dose of CC initiated gonadotropin stimulation without inducing withdrawal bleeding, using the chronic low dose regimen. Read More

    Increased cerebrospinal fluid levels of GABA, testosterone and estradiol in women with polycystic ovary syndrome.
    Hum Reprod 2017 Apr 27:1-7. Epub 2017 Apr 27.
    Section of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157.
    Study Question: Do cerebrospinal fluid (CSF) concentrations of gamma-aminobutyric acid (GABA), testosterone (T) and estradiol (E2) differ in women with polycystic ovary syndrome (PCOS) as compared to eumenorrheic, ovulatory women (EW)?

    Summary Answer: Women with PCOS displayed higher CSF levels of GABA and E2, and possibly T, than EW.

    What Is Known Already: The chronic anovulation characteristic of PCOS has been attributed to increased central GnRH drive and resulting gonadotropin aberrations. Androgens are thought to regulate GABA, which in turn regulates the neural cascade that modulates GnRH drive. Read More

    Fat Mass and Obesity Associated Gene Polymorphism and the Risk of Polycystic Ovary Syndrome: A Meta-analysis.
    Iran J Public Health 2017 Jan;46(1):4-11
    Dept. of Gynecology, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
    Background: We aimed to elucidate the association between fat mass and obesity associated gene (FTO) polymorphism and the risk of polycystic ovary syndrome (PCOS) by meta-analysis.

    Methods: We searched PubMed and Embase databases to find the relevant studies. Odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were used for pooled analysis. Read More

    Predicting the outcome of different protocols of in vitro fertilization with anti-Muüllerian hormone levels in patients with polycystic ovary syndrome.
    J Int Med Res 2017 Jan 1:300060517704140. Epub 2017 Jan 1.
    1 Reproductive Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
    Objective This study evaluated associations of basal serum and follicular fluid (FF) anti-Muüllerian hormone (AMH) levels with in vitro fertilization (IVF) outcomes in polycystic ovary syndrome (PCOS) patients. Methods This prospective study included 179 consecutive women undergoing IVF, including 59 with PCOS and non-PCOS controls. Thirty PCOS cases had long gona-dotrophin-releasing hormone agonist (GnRH-a) and 29 had antagonist (GnRH-ant) protocols. Read More

    The use of cyproterone acetate/ethinyl estradiol in hyperandrogenic skin symptoms - a review.
    Eur J Contracept Reprod Health Care 2017 Apr 27:1-10. Epub 2017 Apr 27.
    c Departamento de Ginecologia e Obstetrícia da UFMG , Belo Horizonte , Brazil.
    Introduction: Hyperandrogenism affects approximately 10-20% of women of reproductive age. Hyperandrogenic skin symptoms such as hirsutism, acne, seborrhea and alopecia are associated with significant quality of life and psychological impairment. Women with abnormalities in androgen metabolism may have accompanying anovulation and/or polycystic ovary syndrome (PCOS), both of which have reproductive and metabolic implications if left untreated. Read More

    Mice endometrium receptivity in early pregnancy is impaired by maternal hyperinsulinemia.
    Mol Med Rep 2017 Mar 14. Epub 2017 Mar 14.
    Laboratory of Reproductive Biology, School of Public Health, Chongqing Medical University, Chongqing 400014, P.R. China.
    Previous studies have investigated the lower embryo implantation rates in women with polycystic ovary syndrome, obesity and type 2 diabetes, and specifically the association between the abnormal oocyte and embryo and hyperinsulinemia. The importance of hyperinsulinemia on maternal endometrium receptivity remains to be elucidated. The present study used a hyperinsulinemic mouse model to determine whether hyperinsulinemia may affect endometrial receptivity. Read More

    Current Dilemmas in Defining the Boundaries of Disease.
    J Med Philos 2017 Apr 21. Epub 2017 Apr 21.
    Macquarie University, Sydney, New South Wales, Australia.
    Boorse's biostatistical theory states that diseases should be defined in ways that reflect disturbances of biological function and that are objective and value free. We use three examples from contemporary medicine that demonstrate the complex issues that arise when defining the boundaries of disease: polycystic ovary syndrome, chronic kidney disease, and myocardial infarction. We argue that the biostatistical theory fails to provide sufficient guidance on where the boundaries of disease should be drawn, contains ambiguities relating to choice of reference class, and is out of step with medical processes for identifying disease boundaries. Read More

    Epidemiology of ovarian cancer: a review.
    Cancer Biol Med 2017 Feb;14(1):9-32
    Department of Cancer Epidemiology, Division of Population Sciences, Moffitt Cancer Center, Tampa 33612, FL, USA.
    Ovarian cancer (OC) is the seventh most commonly diagnosed cancer among women in the world and the tenth most common in China. Epithelial OC is the most predominant pathologic subtype, with five major histotypes that differ in origination, pathogenesis, molecular alterations, risk factors, and prognosis. Genetic susceptibility is manifested by rare inherited mutations with high to moderate penetrance. Read More

    Intracytoplasmic oxidative stress reverses epigenetic modifications in polycystic ovary syndrome.
    Reprod Fertil Dev 2017 Apr 26. Epub 2017 Apr 26.
    In polycystic ovary syndrome (PCOS), substantial genetic and environmental alterations, along with hyperandrogenism, affect the quality of oocytes and decrease ovulation rates. To determine the mechanisms underlying these alterations caused specifically by an increase in plasma androgens, the present study was performed in experimentally-induced PCOS mice. As the study model, female B6D2F1 mice were treated with dehydroepiandrosterone (DHEA, 6mg per 100g bodyweight). Read More

    [Analysis of funding of projects on obstetrics and gynecology supported by National Natural Science Foundation of China from 2007 to 2016].
    Zhonghua Fu Chan Ke Za Zhi 2017 Apr;52(4):254-260
    Department of Obstetrics and Gynecology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
    Objective: To summarize the funding of scientific research projects on obstetrics and gynecology by National Natural Science Foundation of China (NSFC) from 2007 to 2016 and to display the hotspots of scientific research on obstetrics and gynecology. Methods: A systemic search was performed for the information of projects supported by NSFC from 2007 to 2016. The indicators for analysis included the number of projects, total investment, project categories, research units and research field. Read More

    High Prevalence of Polycystic Ovary Syndrome in Type 1 Diabetes Mellitus Adolescents: Is There a Difference Depending on the NIH and Rotterdam Criteria?
    Horm Res Paediatr 2017 Apr 24;87(5):333-341. Epub 2017 Apr 24.
    Background: Polycystic ovary syndrome (PCOS) is more frequently observed in type 1 diabetes mellitus (T1DM) adult women than in nondiabetic women. No such prevalence has yet been studied in adolescent girls with T1DM.

    Aim: The aim of this study was to evaluate the prevalence of PCOS in adolescent girls with T1DM and to determine the clinical and hormonal features associated with the disorder. Read More

    Endocr Pract 2017 Apr;23(Suppl 2):1-87
    Objective: The development of these guidelines is mandated by the American Association of Clinical Endocrinologists (AACE) Board of Directors and American College of Endocrinology (ACE) Board of Trustees and adheres with published AACE protocols for the standardized production of clinical practice guidelines (CPGs).

    Methods: Recommendations are based on diligent reviews of the clinical evidence with transparent incorporation of subjective factors, according to established AACE/ACE guidelines for guidelines protocols.

    Results: The Executive Summary of this document contains 87 recommendations of which 45 are Grade A (51. Read More

    Myoinositol combined with alpha-lipoic acid may improve the clinical and endocrine features of polycystic ovary syndrome through an insulin-independent action.
    Gynecol Endocrinol 2017 Apr 23:1-4. Epub 2017 Apr 23.
    a Department of Obstetrics and Gynecology , Università Cattolica del Sacro Cuore , Roma , Italy and.
    The aim of our study was to investigate the effects of a combined treatment with alpha-lipoic acid (ALA) and myoinositol (MYO) on clinical, endocrine and metabolic features of women affected by polycystic ovary syndrome (PCOS). In this pilot cohort study, forty women with PCOS were enrolled and clinical, hormonal and metabolic parameters were evaluated before and after a six-months combined treatment with ALA and MYO daily. Studied patients experienced a significant increase in the number of cycles in six months (p < 0. Read More

    Weight loss in obese girls with polycystic ovarian syndrome is associated with a decrease of Anti Muellerian Hormone concentrations.
    Clin Endocrinol (Oxf) 2017 Apr 22. Epub 2017 Apr 22.
    Department of Pediatrics, Division of Pediatric Endocrinology and Diabetes, University Hospital of Schleswig - Holstein, UKSH, Campus Kiel / Christian Albrechts University of Kiel, CAU, Kiel, Germany.
    Objective: The Anti- Muellerian Hormone (AMH) has been reported as surrogate marker of antral follicles, which are the origins of hyperandrogenism in polycystic ovarian syndrome (PCOS). Therefore, AMH may be useful for the diagnosis of PCOS. The objective was to study the longitudinal changes in AMH concentrations in girls with and without PCOS. Read More

    Prohibitin-induced obesity leads to anovulation and polycystic ovary in mice.
    Biol Open 2017 Apr 21. Epub 2017 Apr 21.
    Department of Internal Medicine, University of Manitoba, Winnipeg, Canada
    Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder and the most common cause of female infertility. However, the etiology of the disease and the mechanisms by which this disorder progress remain unclear. Here we report that a transgenic obese mouse (Mito-Ob) developed by overexpressing prohibitin in adipocytes develops polycystic ovaries. Read More

    Effect of oral contraceptives and/or metformin on GLP-1 secretion and reactive hypoglycemia in PCOS.
    Endocr Connect 2017 Apr 21. Epub 2017 Apr 21.
    M Andersen, Odense C, Denmark.
    Context: Insulin resistance in polycystic ovary syndrome (PCOS) may increase the risk of reactive hypoglycaemia (RH) and decrease glucagon-like peptide-1 (GLP-1) secretion. The possible effects of treatment with oral contraceptives (OCP) and/or metformin on GLP-1 secretion and risk of RH in PCOS is undetermined.

    Setting: Outpatient clinic. Read More

    Follicular fluid cerebellin and betatrophin regulate the metabolic functions of growing follicles in polycystic ovary syndrome.
    Clin Exp Reprod Med 2017 Mar 31;44(1):33-39. Epub 2017 Mar 31.
    Department of Medical Biochemistry (Firat Hormones Research Group), Firat University School of Medicine, Elazig, Turkey.
    Objective: The aim of this study was to assess the changes of follicular fluid (FF) and serum levels of cerebellin precursor protein 1 (cbln1) and betatrophin in patients with polycystic ovary syndrome (PCOS) undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) with a gonadotropin-releasing hormone (GnRH) antagonist protocol.

    Methods: Twenty infertile women with PCOS and 20 control women diagnosed as poor responders undergoing ovarian stimulation with a GnRH antagonist were included. Blood samples were obtained during ovum pick-up. Read More

    Effects of supervised aerobic training on the levels of anti-Mullerian hormone and adiposity measures in women with normo-ovulatory and polycystic ovary syndrome.
    J Pak Med Assoc 2017 Apr;67(4):499-507
    Rehabilitation Research Chair, College of Applied Medical Sciences, King Saud University, Riyadh, KSA.
    Objective: To evaluate the change in the levels of anti-Mullerian hormone, adiponectin, weight loss and fertility parameters in obese women with or without polycystic ovary syndrome, following 12 weeks of supervised aerobic exercise.

    Methods: This study was conducted from August 2013 to October 2014 among obese women with or without polycystic ovary syndrome referred to Obstetrics and Gynecology clinic, Mansoura University Hospital, Faculty of Medicine, Mansoura, Egypt. Patients were classified into three age-matched groups; group A had controls, group B had patients with polycystic ovary syndrome and group C had obese women. Read More

    High insulin impaired ovarian function in early pregnant mice and the role of autophagy in this process.
    Endocr J 2017 Apr 18. Epub 2017 Apr 18.
    Laboratory of Reproductive Biology, School of Public Health, Chongqing Medical University, Chongqing 400016, China.
    Metabolic disorders, such as PCOS (polycystic ovarian syndrome) and T2DM (type 2 diabetes mellitus), are associated with menstrual dysfunction, anovulation, infertility, and early pregnancy loss. Ovarian dysfunction is not only related to low pregnancy rates but also to the increased risk of miscarriage. Women with PCOS or T2DM, characterized by hyperinsulinemia, commonly experience ovarian dysfunction. Read More

    The impact of laparoscopic ovarian drilling on AMH & ovarian reserve: a meta-analysis.
    Reproduction 2017 Apr 18. Epub 2017 Apr 18.
    A Mohamed, Obstetrics and Gynaecology, University of Nottingham, Derby, United Kingdom of Great Britain and Northern Ireland.
    Laparoscopic ovarian drilling (LOD) has been widely utilised as an effective treatment in anovulatory women with polycystic ovarian syndrome (PCOS). However, there has been a growing concern over a possible damaging effect of this procedure on ovarian reserve. The objective of this study was to investigate the hypothesis that LOD compromises ovarian reserve as measured by post-operative changes in circulating anti-Müllerian hormone (AMH). Read More

    Follicular ADAMTS-1 and aggrecan levels in polycystic ovary syndrome.
    J Assist Reprod Genet 2017 Apr 17. Epub 2017 Apr 17.
    Faculty of Medicine, Department of Gynecology and Obstetrics, In vitro Fertilization Unit, Suleyman Demirel University, Isparta, Turkey.
    Purpose: Polycystic ovary syndrome (PCOS) is the most common cause of ovulatory dysfunction and female infertility. The etiopathogenetic mechanisms of PCOS have been studied for many years, although exact causes remain unclear. It has been demonstrated that proteoglycan degradation by a disintegrin-like metalloproteinase with thrombospondin type motifs-1 (ADAMTS-1) is essential for ovulation and fertilization. Read More

    Nutritional management in women with polycystic ovary syndrome: A review study.
    Diabetes Metab Syndr 2017 Apr 5. Epub 2017 Apr 5.
    Imam Hospital of Borujerd, Lorestan University of Medical Sciences, Khorram-Abad, Iran. Electronic address:
    Polycystic ovary syndrome (PCOS) is endocrine disorder in women of reproductive age, which leads to reproductive, hormonal and metabolic abnormalities. Due to the presence of insulin resistance, PCOS increases the risk of chronic diseases like type 2 diabetes, hypertension, lipid disorders, cardiovascular diseases and malignancies such as breast and endometrial cancer. The actual cause of this syndrome is unknown but environmental factors such as dietary habits play an important role in prevention and treatment and lifestyle modifications are the most important therapeutic strategies in these patients. Read More

    -A curated transcriptomic dataset collection relevant to embryonic development associated with in vitro fertilization in healthy individuals and patients with polycystic ovary syndrome.
    F1000Res 2017 23;6:181. Epub 2017 Feb 23.
    Department of Human Genetics, Division of Translational Medicine, Sidra Medical and Research Center, Doha, 26999, Qatar.
    The collection of large-scale datasets available in public repositories is rapidly growing and providing opportunities to identify and fill gaps in different fields of biomedical research. However, users of these datasets should be able to selectively browse datasets related to their field of interest. Here we made available a collection of transcriptome datasets related to human follicular cells from normal individuals or patients with polycystic ovary syndrome, in the process of their development, during in vitro fertilization. Read More

    Obesity contributes more to increasing ApoB/ApoA1 ratio than hyperandrogenism in PCOS women aged 20-38 years in China.
    Exp Ther Med 2017 Apr 31;13(4):1337-1342. Epub 2017 Jan 31.
    Department of Gynecology and Obstetrics, Xuzhou Central Hospital Affiliated to Southeast University, Xuzhou, Jiangsu 221009, P.R. China.
    We investigated the association between the apolipoprotein B (ApoB)/apolipoprotein A1 (ApoA1) ratio and insulin resistance (IR), metabolic syndrome (MS) and its components in Chinese polycystic ovary syndrome (PCOS) adults. We also examined whether hyperandrogenism is involved in obesity-related metabolic abnormalities in a cohort of patients. A clinical cross-sectional study consisting of 532 Chinese PCOS adults aged 20-38 years was designed. Read More

    Impact of transvaginal hydrolaparoscopy ovarian drilling on ovarian stromal blood flow and ovarian volume in clomiphene citrate-resistant PCOS patients: a case-control study.
    Gynecol Endocrinol 2017 Apr 17:1-4. Epub 2017 Apr 17.
    b Department of Obstetrics, Gynecology, and Urology, University of Naples "Federico II" , Naples , Italy , and.
    Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder in gynecology. In PCOS patients vascularization parameters are altered. Transvaginal hydrolaparoscopy (THL) is a mini-invasive approach for ovarian drilling in PCOS patients. Read More

    Prevalence of diminished ovarian reserve in Chinese women with polycystic ovary syndrome and sensitive diagnostic parameters.
    Gynecol Endocrinol 2017 Apr 17:1-4. Epub 2017 Apr 17.
    a Department of Gynecological Endocrinology , Beijing Obstetrics and Gynecology Hospital, Capital Medical University , Beijing , China.
    Objectives: To assess the prevalence of diminished ovarian reserve (DOR) in patients with polycystic ovary syndrome (PCOS) in China, and to search for sensitive diagnostic parameters.

    Methods: Three hundred and thirty eight PCOS women aged 20-39 years were recruited. Basic characteristics, follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), testosterone and anti-Müllerian hormone (AMH) were measured. Read More

    Enhanced Inflammation without Impairment of Insulin Signaling in the Visceral Adipose Tissue of 5α-Dihydrotestosterone-Induced Animal Model of Polycystic Ovary Syndrome.
    Exp Clin Endocrinol Diabetes 2017 Apr 13. Epub 2017 Apr 13.
    Clinic of Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia and Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
    Polycystic ovary syndrome is a heterogeneous endocrine and metabolic disorder associated with abdominal obesity, dyslipidemia and insulin resistance. Since abdominal obesity is characterized by low-grade inflammation, the aim of the study was to investigate whether visceral adipose tissue inflammation linked to abdominal obesity and dyslipidemia could lead to impaired insulin sensitivity in the animal model of polycystic ovary syndrome.Female Wistar rats were treated with nonaromatizable 5α-dihydrotestosterone pellets in order to induce reproductive and metabolic characteristics of polycystic ovary syndrome. Read More

    The Effects of Calcium, Vitamins D and K co-Supplementation on Markers of Insulin Metabolism and Lipid Profiles in Vitamin D-Deficient Women with Polycystic Ovary Syndrome.
    Exp Clin Endocrinol Diabetes 2017 Apr 13. Epub 2017 Apr 13.
    Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I.R. Iran.
    Data on the effects of calcium, vitamins D and K co-supplementation on markers of insulin metabolism and lipid profiles among vitamin D-deficient women with polycystic ovary syndrome (PCOS) are scarce. This study was done to determine the effects of calcium, vitamins D and K co-supplementation on markers of insulin metabolism and lipid profiles in vitamin D-deficient women with PCOS. This randomized double-blind, placebo-controlled trial was conducted among 55 vitamin D-deficient women diagnosed with PCOS aged 18-40 years old. Read More

    The Effects of Omega-3 Fatty Acids and Vitamin E Co-Supplementation on Indices of Insulin Resistance and Hormonal Parameters in Patients with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Exp Clin Endocrinol Diabetes 2017 Apr 13. Epub 2017 Apr 13.
    Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I.R. Iran.
    This study was conducted to determine the effects of omega-3 fatty acids and vitamin E co-supplementation on indices of insulin resistance and hormonal parameters in women with polycystic ovary syndrome (PCOS). This randomized double-blind, placebo-controlled trial was done on 68 women diagnosed with PCOS according to the Rotterdam criteria aged 18-40 years old. Participants were randomly assigned into 2 groups to receive either 1 000 mg omega-3 fatty acids from flaxseed oil containing 400 mg α-Linolenic acid plus 400 IU vitamin E supplements (n=34) or placebo (n=34) for 12 weeks. Read More

    The elusive MAESTRO gene: Its human reproductive tissue-specific expression pattern.
    PLoS One 2017 13;12(4):e0174873. Epub 2017 Apr 13.
    CReATe Fertility Centre, Toronto, Canada.
    The encoded transcript of the Maestro-Male-specific Transcription in the developing Reproductive Organs (MRO) gene exhibits sexual dimorphic expression during murine gonadal development. The gene has no homology to any known gene and its expression pattern, protein function or structure are still unknown. Previously, studying gene expression in human ovarian cumulus cells, we found increased expression of MRO in lean-type Polycystic Ovarian Syndrome (PCOS) subjects, as compared to controls. Read More

    Homeostatic Model Assessment for Insulin Resistance (HOMA-IR): A Better Marker for Evaluating Insulin Resistance Than Fasting Insulin in Women with Polycystic Ovarian Syndrome.
    J Coll Physicians Surg Pak 2017 Mar;27(3):123-126
    Department of Pathology and Laboratory Medicine, The Aga Khan University Hospital, Karachi.
    Objective: To assess the utility of HOMA-IR in assessing insulin resistance in patients with polycystic ovary syndrome (PCOS) and compare it with fasting insulin for assessing insulin resistance (IR).

    Study Design: Observational study.

    Place And Duration Of Study: Section of Clinical Chemistry, Department of Pathology and Laboratory Medicine, The Aga Khan University Hospital, Karachi, from January 2009 to September 2012. Read More

    Association of IL-1β, IL-1Ra and FABP1 gene polymorphisms with the metabolic features of polycystic ovary syndrome.
    Inflamm Res 2017 Apr 12. Epub 2017 Apr 12.
    Department of Biotechnology, School of Chemical and Life Sciences, Jamia Hamdard (Hamdard University), New Delhi, 110062, India.
    Background: Polycystic ovary syndrome (PCOS), a highly prevalent endocrinopathy is currently being designated as chronic low grade inflammatory state. IL-1β, IL-1Ra and FABP1 are critical mediators of inflammatory processes and are speculated to play a role in the pathogenesis of PCOS. The aim of this study was to study the association of IL-β, IL-1Ra and FABP1 gene polymorphisms with PCOS and related metabolic features. Read More

    Cutaneous Manifestations of Polycystic Ovary Syndrome: A Cross-Sectional Clinical Study.
    Indian Dermatol Online J 2017 Mar-Apr;8(2):104-110
    Department of Dermatology, STD and Leprosy, GMC Srinagar and associated SMHS Hospital, Srinagar, Jammu and Kashmir, India.
    Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women, affecting 5-10% of reproductive-aged women. The dermatologic manifestations of hyperandrogenism, chiefly hirsutism, acne vulgaris, androgenic alopecia, and acanthosis nigricans, are among the cardinal manifestations of PCOS.

    Aim: To study the incidence and prevalence of various cutaneous manifestations in patients with PCOS and to correlate these skin manifestations with hormonal changes. Read More

    Impact of metformin on C-reactive protein levels in women with polycystic ovary syndrome: a meta-analysis.
    Oncotarget 2017 Mar 8. Epub 2017 Mar 8.
    Department of Clinical Laboratory, The First Affiliated Hospital of Hunan Normal University, People's Hospital of Hunan, Hunan, People's Republic of China.
    The impact of the recommended first-line treatment with metformin on C-reactive protein (CRP) levels in patients with polycystic ovary syndrome (PCOS) is still controversial. We conducted a meta-analysis of studies reporting the impact of metformin on serum CRP levels in women with PCOS. The weighted mean differences (WMDs) and the corresponding 95% confidence intervals (CIs) were used to assesse the effects. Read More

    Autonomic nervous system activation mediates the increase in whole-body glucose uptake in response to electroacupuncture.
    FASEB J 2017 Apr 12. Epub 2017 Apr 12.
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden;
    A single bout of low-frequency electroacupuncture (EA) causing muscle contractions increases whole-body glucose uptake in insulin-resistant rats. We explored the underlying mechanism of this finding and whether it can be translated into clinical settings. Changes in glucose infusion rate (GIR) were measured by euglycemic-hyperinsulinemic clamp during and after 45 min of low-frequency EA in 21 overweight/obese women with polycystic ovary syndrome (PCOS) and 21 controls matched for age, weight, and body mass index (experiment 1) and in rats receiving autonomic receptor blockers (experiment 2). Read More

    The WNT/β-catenin signaling pathway may be involved in granulosa cell apoptosis from patients with PCOS in North China.
    J Gynecol Obstet Hum Reprod 2017 Jan 21;46(1):93-99. Epub 2015 Oct 21.
    Center of Reproductive Medicine, Shanxi Women and Children Health Hospital, No. 13, Xinmin North Street, Xinghualing District, 030013, Taiyuan, Shanxi, China.
    Introduction: Investigate the expressions of WNTs in granulosa cells of PCOS in North China, and explore the possible mechanism.

    Material And Methods: Patients with PCOS (n=40) and controls without PCOS (n=20) were enrolled into the study. The levels of serum sex hormone were detected by chemiluminescent enzyme immunoassay. Read More

    Frequency of nodular goiter and autoimmune thyroid disease and association of these disorders with insulin resistance in polycystic ovary syndrome.
    J Turk Ger Gynecol Assoc 2017 Feb 7. Epub 2017 Feb 7.
    Objective: Polycystic ovary syndrome (PCOS) is a frequent endocrine disease in women. Nodular goiter and autoimmune thyroid disease (AITD) are the endocrinological abnormalities that have high prevalence. The purpose of our study was to detect the prevalence of AITD and nodular goiter in PCOS patients and investigate whether PCOS related hormones and metabolic factors affect these thyroid disorders. Read More

    Racial and Ethnic Differences in the Prevalence of Metabolic Syndrome and its Components of Metabolic Syndrome in Women with Polycystic Ovary Syndrome (PCOS): A Regional Cross-Sectional Study.
    Am J Obstet Gynecol 2017 Apr 8. Epub 2017 Apr 8.
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Pennsylvania, 3701 Market Street, Suite 800, Philadelphia, Philadelphia, PA, 19104, U.S.A. Electronic address:
    Background: - PCOS is a heterogeneous disorder and its presentation varies with race and ethnicity. Reproductive age women with PCOS are at increased risk of metabolic syndrome however, it is not clear if prevalence of metabolic syndrome and clustering of its components differs based on race and ethnicity. Moreover, the majority of these women do not undergo routine screening for metabolic syndrome. Read More

    Thyroid-stimulating Hormone and Insulin Resistance: Their Association with Polycystic Ovary Syndrome without Overt Hypothyroidism.
    Rev Bras Ginecol Obstet 2017 Apr 11. Epub 2017 Apr 11.
    Department of Clinics, Faculdade de Medicina da Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil.
    Objective This study analyzed the effectiveness of the thyroid-stimulating hormone (TSH) as a predictor of insulin resistance (IR) and its association with the clinical and metabolic parameters of women with polycystic ovary syndrome (PCOS) without overt hypothyroidism. Study Design A cross-sectional study was performed. Women with PCOS and without overt hypothyroidism (n = 168) were included. Read More

    ATP synthase β-subunit abnormality in pancreas islets of rats with polycystic ovary syndrome and type 2 diabetes mellitus.
    J Huazhong Univ Sci Technolog Med Sci 2017 Apr 11;37(2):210-216. Epub 2017 Apr 11.
    Department of Gynecology and Obstetrics, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
    This study investigated the abnormal expression of ATP synthase β-subunit (ATPsyn-β) in pancreas islets of rat model of polycystic ovary syndrome (PCOS) with type 2 diabetes mellitus (T2DM), and the secretion function changes after up-regulation of ATP5b. Sixty female SD rats were divided into three groups randomly and equally. The rat model of PCOS with T2DM was established by free access to the high-carbohydrate/high-fat diet, subcutaneous injections of DHEA, and a single injection of streptozotocin. Read More

    Using gonadotropin-releasing hormone agonist before frozen embryo transfer may improve ongoing pregnancy rates in hyperandrogenic polycystic ovary syndrome women.
    Gynecol Endocrinol 2017 Apr 10:1-4. Epub 2017 Apr 10.
    a Department of Obstetrics and Gynecology , Kaohsiung Veterans General Hospital , Kaohsiung , Taiwan.
    Polycystic ovary syndrome (PCOS), affecting more than 5-10% of woman at reproductive childbearing age, is characterized by anovulation and hyperandrogenism. Frozen-thawed embryo transfer (ET) has been widely used for PCOS women to minimize the risk of ovarian hyperstimulation syndrome. However, the hyperandrogenic status of PCOS women deteriorates endometrial function, which has subsequently increased miscarriage rates in PCOS women. Read More

    Metabolic Outcomes, Bone Health, and Risk of Polycystic Ovary Syndrome in Girls with Idiopathic Central Precocious Puberty Treated with Gonadotropin-Releasing Hormone Analogues.
    Horm Res Paediatr 2017 7;87(3):162-169. Epub 2017 Apr 7.
    Background/aims: Gonadotropin-releasing hormone analogues (GnRHa) represent the gold standard treatment for central precocious puberty (CPP). We aimed to assess the effects of GnRHa treatment on metabolic outcomes, bone status, and polycystic ovary syndrome (PCOS) prevalence in young girls with idiopathic CPP (ICPP).

    Methods: We enrolled 94 ICPP girls who were at least 2 years after menarche and had already attained adult height at the time of the study: 56 previously treated with depot triptorelin (3. Read More

    Environmental pollutants, a possible etiology for premature ovarian insufficiency: a narrative review of animal and human data.
    Environ Health 2017 Apr 7;16(1):37. Epub 2017 Apr 7.
    Médecine de la Reproduction, CHU de Toulouse, Hôpital Paule de Viguier, 330 avenue de Grande Bretagne, F-31059, Toulouse Cedex, France.
    Background: Because only 25% of cases of premature ovarian insufficiency (POI) have a known etiology, the aim of this review was to summarize the associations and mechanisms of the impact of the environment on this pathology. Eligible studies were selected from an electronic literature search from the PUBMED database from January 2000 to February 2016 and associated references in published studies. Search terms included ovary, follicle, oocyte, endocrine disruptor, environmental exposure, occupational exposure, environmental contaminant, pesticide, polyaromatic hydrocarbon, polychlorinated biphenyl PCB, phenol, bisphenol, flame retardant, phthalate, dioxin, phytoestrogen, tobacco, smoke, cigarette, cosmetic, xenobiotic. Read More

    Progesterone Receptors and Proliferation of the Endometrium in Obese Women With Polycystic Ovary Syndrome-A Lifestyle Intervention Study.
    J Clin Endocrinol Metab 2017 Apr;102(4):1244-1253
    Division of Obstetrics and Gynecology, and.
    Context: Polycystic ovary syndrome (PCOS) is associated with increased risk of endometrial cancer. This is usually explained by chronic anovulation and deficient progesterone activity. However, the role of progesterone receptors (PRs) in endometrial proliferation is unclear. Read More

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