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    16205 results match your criteria Polycystic Ovarian Syndrome

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    A Retrospective Study of Letrozole Treatment Prior to Human Chorionic Gonadotropin in Women with Polycystic Ovary Syndrome Undergoing In Vitro Fertilization at Risk of Ovarian Hyperstimulation Syndrome.
    Med Sci Monit 2018 Jun 20;24:4248-4253. Epub 2018 Jun 20.
    Reproductive Center, Department of Obstetrics and Gynaecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China (mainland).
    BACKGROUND Women with polycystic ovary syndrome (PCOS) undergoing in vitro fertilization (IVF) are given letrozole before a trigger injection of human chorionic gonadotropin (hCG) to lower estrogen (E2) levels, but can experience ovarian hyperstimulation syndrome (OHSS). The aim of this study was to evaluate the effect of oral letrozole, prior to administration of hCG, on the outcome of IVF and development of OHSS. MATERIAL AND METHODS Retrospective clinical review included 181 cases of women with PCOS who underwent IVF cycles with intracytoplasmic sperm injection (ICSI) and embryo transfer (ET) (IVF/ICSI-ET). Read More

    Diagnosis and follow-up of type 2 diabetes in women with PCOS. A role of OGTT?
    Eur J Endocrinol 2018 Jun 19. Epub 2018 Jun 19.
    D Glintborg, Endocrinology, Odense University Hospital, Odense , DK-5000, Denmark.
    Polycystic ovary syndrome (PCOS) is common in premenopausal women. The majority of women with PCOS have insulin resistance and the risk of type 2 diabetes mellitus (T2D) is higher in women with PCOS compared to controls. In non-pregnant women with PCOS, glycemic status may be assessed by oral glucose tolerance test (OGTT), fasting plasma glucose (FPG), or HbA1c. Read More

    No. 362-Ovulation Induction in Polycystic Ovary Syndrome.
    J Obstet Gynaecol Can 2018 Jul;40(7):978-987
    Vancouver, BC.
    Objective: To review current non-pharmacologic and pharmacologic options for ovulation induction in women with polycystic ovary syndrome (PCOS).

    Options: This guideline reviews the evidence for the various options for ovulation induction in PCOS.

    Outcomes: Ovulation, pregnancy and live birth rates, risks, and side effects are the outcomes of interest. Read More

    The role of MiR-324-3p in polycystic ovary syndrome (PCOS) via targeting WNT2B.
    Eur Rev Med Pharmacol Sci 2018 Jun;22(11):3286-3293
    The Children and Women's Health Care Hospital of Laiwu City, Laiwu, China.
    Objective: To investigate the expression of microRNA-324-3p (miR-324-3p) in polycystic ovary syndrome (PCOS) and its effects on the proliferation and apoptosis of ovarian granulosa cells.

    Materials And Methods: A total of 60 Sprague-Dawley (SD) rats were randomly divided into normal group (n=30) and experimental group (n=30). Rats in the experimental group were intramuscularly injected with dehydroepiandrosterone (DHEA) (6 mg/100 g of body weight) and 0. Read More

    Comparing the frequency of polycystic ovary syndrome in women with and without epilepsy.
    J Family Med Prim Care 2018 Jan-Feb;7(1):16-20
    Department of Neurology, Iran University of Medical Sciences, Tehran, Iran.
    Introduction: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders; the impact of epilepsy and antiepileptic drugs influences the function of hypothalamic-pituitary-gonadal axis and dysfunction of the endocrine system and reproductive hormones in women with epilepsy. This study was carried out with an aim of determining and comparing the frequency and intensity of the complications of the hirsutism in women with and without epilepsy in Tehran in 2016-2017.

    Materials And Methods: This is a cross-sectional-comparative study which was carried out on 338 women of 18-35-year-old women with and without epilepsy who were selected by continuous sampling method. Read More

    Anxiety and depression states of adolescents with polycystic ovary syndrome
    Turk J Med Sci 2018 Jun 14;48(3):531-536. Epub 2018 Jun 14.
    Background/aim: Various studies have shown that adult patients with polycystic ovary syndrome (PCOS) have higher levels of anxiety and depression compared to their normal counterparts. However, it is still unclear whether these mood disorders already exist in adolescents affected by PCOS. The aim of the present study is to assess differences in anxiety and depression levels between adolescents with PCOS and age- and body mass index (BMI)-matched controls and to determine the possible factor(s) impacting these psychological parameters in adolescents with PCOS. Read More

    Transcriptome analysis of PCOS arrested 2-cell embryos.
    Cell Cycle 2018 Jun 18. Epub 2018 Jun 18.
    a Center for Reproductive Medicine, Department of Obstetrics and Gynecology , Peking University Third Hospital , Beijing , China.
    In an attempt to explore the early developmental arrest in embryos from polycystic ovarian syndrome (PCOS) patients, we sequenced the transcriptome profiles of PCOS arrested 2-cell embryos, non-PCOS arrested 2-cell embryos and non-arrested 2-cell embryos using single-cell RNA-Seq technique. Differential expression analysis was performed using the DEGSeq R package. Gene Ontology (GO) enrichment was analyzed using the GOseq R package. Read More

    Polycystic Ovary Syndrome and Periodontal disease: Underlying Links- A Review.
    Indian J Endocrinol Metab 2018 Mar-Apr;22(2):267-273
    Department of Periodontology, Narayana Dental College and Hospital, Nellore, Andhra Pradesh, India.
    Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of reproductive age, which negatively affects various health systems. There is an extensive literature regarding the association of PCOS and other systemic conditions such as diabetes mellitus, cardiovascular disease, and psychological disorders. However, there is a lack of literature in associating PCOS and periodontal disease. Read More

    Insulin resistance is associated with depression risk in polycystic ovary syndrome.
    Fertil Steril 2018 Jun 13. Epub 2018 Jun 13.
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California-San Francisco, San Francisco, California.
    Objective: To test the hypothesis that insulin resistance is associated with depression risk in polycystic ovary syndrome (PCOS).

    Design: Secondary analysis of data from a multicenter randomized trial.

    Setting: Multicenter university-based clinical practices. Read More

    Cognitive-behavioral therapy improves weight loss and quality of life in women with polycystic ovary syndrome: a pilot randomized clinical trial.
    Fertil Steril 2018 Jun 13. Epub 2018 Jun 13.
    Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:
    Objective: To compare the effects of cognitive-behavioral therapy (CBT) and lifestyle modification (LS) versus LS alone on weight, depressive and anxiety symptoms, and stress response in women with polycystic ovary syndrome (PCOS), overweight/obesity, and depressive symptoms.

    Design: A 16-week pilot randomized clinical trial.

    Setting: Tertiary-care PCOS center. Read More

    Clomiphene citrate increases nitric oxide, interleukin-10 and reduces matrix metalloproteinase-9 in women with polycystic ovary syndrome.
    Eur J Obstet Gynecol Reprod Biol 2018 Jun 8;228:27-31. Epub 2018 Jun 8.
    Department of Biochemistry and Obstetrics and Gynecology, JIPMER, Puducherry, India.
    Objectives: Matrix metalloproteinase-9, Nitric oxide and inflammation plays a role in the pathogenesis of poly cystic ovary syndrome (PCOS). Even though these parameters are altered in PCOS, the effect of clomiphene citrate on them has not been studied till date. The present study was done to assess the effect of clomiphene citrate on matrix metalloproteinase-9, nitric oxide and interleukin-10 levels in women with PCOS. Read More

    Childhood cardiovascular health and subfertility: the Bogalusa Heart Study.
    Pediatr Res 2018 Jun 13. Epub 2018 Jun 13.
    Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA.
    Background: Although childhood cardiovascular risk can contribute to adult cardiovascular disease, and fertility and adult cardiovascular health are linked, the association between early-life cardiovascular risk and female infertility has not been studied.

    Methods: A total of 1799 women participated in the Babies substudy of the Bogalusa Heart Study. Systolic blood pressure (SBP), diastolic blood pressure (DBP), low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides, glucose, and insulin were age-standardized and examined as predictors of self-reported fertility difficulties using multivariable logistic regression with adjustment for confounders. Read More

    Gut microbiota and the polycystic ovary syndrome (PCOS): influence of sex, sex hormones and obesity.
    J Clin Endocrinol Metab 2018 Apr 20. Epub 2018 Apr 20.
    Diabetes Obesity and Human Reproduction Research Group, Department of Endocrinology and Nutrition, Hospital Universitario Ramón y Cajal & Universidad de Alcalá, Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain.
    Context: Gut microbiota plays a major role in health and disease in by influencing physiology and metabolism, nutrition and immune function.

    Objective: We aimed to evaluate the composition of gut microbiota in women with polycystic ovary syndrome (PCOS), focusing on the influence of sex, sex hormones and obesity on the associations found.

    Design: Cross-sectional study. Read More

    Role of exercise training in polycystic ovary syndrome: a systematic review and meta-analysis.
    Clin Obes 2018 Jun 12. Epub 2018 Jun 12.
    Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
    Preliminary evidence suggests exercise in polycystic ovary syndrome (PCOS) may improve reproductive and cardiometabolic parameters. Our primary aim was to determine the impact of exercise training on reproductive health in women with PCOS. Our secondary aim was to determine the effect of exercise training on cardiometabolic indices. Read More

    Prenatal exposures and birth indices, and subsequent risk of polycystic ovary syndrome: a national registry-based cohort study.
    BJOG 2018 Jun 12. Epub 2018 Jun 12.
    Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
    Objective: To study the associations between prenatal exposures and risk of developing polycystic ovary syndrome (PCOS).

    Design: National registry-based cohort study.

    Setting: Sweden. Read More

    Metabolic Syndrome in Hyperprolactinemia.
    Front Horm Res 2018 5;49:29-47. Epub 2018 Apr 5.
    The metabolic syndrome (MetS) is a conglomerate of clinical findings that convey into increased morbidity and mortality from type 2 diabetes mellitus (T2D) and cardiovascular disease. Hyperprolactinemia (hyperPRL) is associated with components of MetS, especially during pregnancy. Endogenous levels of sex steroids are high during pregnancy in contrast to untreated or replaced hypogonadism in most patients with a prolactinoma and hypogonadism may confer increased risk of MetS in hyperPRL. Read More

    Metabolic Syndrome in Polycystic Ovary Syndrome.
    Front Horm Res 2018 5;49:114-130. Epub 2018 Apr 5.
    Both prevalence and incidence of the metabolic syndrome is very high in women with polycystic ovary syndrome (PCOS). Obesity and visceral fat enlargement play a dominant role in determining the final phenotype of PCOS. Androgen excess and insulin resistance may be responsible for the development of all features of the metabolic syndrome. Read More

    Prevalence of hypovitaminosis D, and its association with hypoadiponectinemia and hyperfollistatinemia, in Saudi women with naïve polycystic ovary syndrome.
    J Clin Transl Endocrinol 2018 Jun 15;12:20-25. Epub 2018 Apr 15.
    Department of Clinical Nutrition, Faculty of Applied Medical Sciences, Umm Al-Qura University, PO Box 7607, Holy Makkah, Saudi Arabia.
    Aims: The association between vitamin D and polycystic ovary syndrome (PCOS) is an active area of growing research. However, data in Saudi Arabia are scarce. This study aimed to define serum 25-hydroxyvitamin D (25(OH)D) levels among Saudi women with naïve PCOS, and to investigate the associations of their 25(OH)D status with their serum adiponectin and follistatin levels, along with indices of insulin resistance and hormonal deteriorations. Read More

    The Effect of Metformin Therapy for Preventing Gestational Diabetes Mellitus in Women with Polycystic Ovary Syndrome: A Meta-Analysis.
    Exp Clin Endocrinol Diabetes 2018 Jun 11. Epub 2018 Jun 11.
    Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China.
    Objective: This study was to analyze the efficacy of metformin intervention in preventing gestational diabetes mellitus (GDM).

    Methods: A systematic review and meta-analysis of clinical trials or observational studies of metformin intervention in preventing symptoms of GDM during pregnancy were performed. Medline, Embase, and Cochrane Library were searched through to now. Read More

    Ovulation induction in polycystic ovary syndrome.
    Acta Obstet Gynecol Scand 2018 Jun 11. Epub 2018 Jun 11.
    Department of Reproductive Medicine, Oslo University Hospital, Oslo, Norway.
    The objective of this narrative review is to suggest a rational order of treatment choices in anovulatory women with polycystic ovary syndrome (PCOS), for whom a multitude of treatment options exist. In obese/overweight PCOS patients the importance of weight reduction should be stressed. Inositol, a dietary supplement with a documented effect on ovulation and without side effects in the doses recommended, may be suggested. Read More

    [Acupuncture Treatment of Polycystic Ovarian Syndrome Patients with Abdominal Obesity by Regulating Dai Meridian: A Randomized Controlled Clinical Trial].
    Zhen Ci Yan Jiu 2018 Apr;43(4):255-9
    Department of Acupuncture and Moxibustion, Dongfang Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100078, China.
    Objective: To explore the therapeutic effect of acupuncture in the treatment of polycystic ovarian syndrome (PCOS) patients with abdominal obesity by regulating glucose metabolism, insulin resistance, sex hormones, etc.

    Methods: Eligible PCOS volunteers were randomly divided into treatment group(=30) and control group(=28). The treatment group received acupuncture therapy three times a week combined with diet control and exercise. Read More

    Effect of chamomile capsule on lipid- and hormonal-related parameters among women of reproductive age with polycystic ovary syndrome.
    J Res Med Sci 2018 26;23:33. Epub 2018 Apr 26.
    Maternal -Fetal Medicine Research Center, Department of Midwifery, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran.
    Background: According to traditional herbal medicine, chamomile has been considered as one of the herbal remedies for patients with polycystic ovary syndrome (PCOS). The study aimed to investigate the effect of chamomile on lipid and hormonal parameters in women of reproductive age with PCOS.

    Materials And Methods: This study is a randomized clinical trial which was conducted on 80 women (40 patients in each group) of childbearing age with PCO. Read More

    Metformin treatment prevents gallstone formation but mimics porcelain gallbladder in C57Bl/6 mice.
    Eur J Pharmacol 2018 Jun 5;833:165-172. Epub 2018 Jun 5.
    Department of Pharmacology and Toxicology, Shiraz School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:
    Gallstone disease (GD) is highly correlated with metabolic syndrome and its related illnesses including type II diabetes (DMII) and polycystic ovary syndrome (PCOS). While previous studies claimed that metformin decreases the chance of developing GD in PCOS patients, this phenomenon has not been investigated in animal models to date. Here we fed a high fat diet (HFD) containing 2% of cholesterol and 1% of cholic acid to ten-week-old male C57Bl/6 mice for 105 days. Read More

    The effects of different therapeutic modalities on cardiovascular risk factors in women with polycystıc ovary syndrome: A randomızed controlled study.
    Taiwan J Obstet Gynecol 2018 Jun;57(3):411-416
    Haydarpasa Sultan Abdülhamit Training and Research Hospital, Department of Obstetrics and Gynecology, Istanbul, Turkey.
    Objective: This study was designed to evaluate the effects of 3 mg drospirenone/30 μg ethinyl estradiol (OC) alone or combined with 1700 mg metformin on metabolic risk factors.

    Materials And Methods: In this randomized, prospective, controlled study, 87 non-obese (18-30 BMI) women of reproductive age (18-39) with polycystic ovary syndrome (PCOS) were assigned to control (n = 17), OC (n = 21), combination (n = 20) and metformin (n = 29) therapy groups.

    Results: Adiponectin levels changed -28. Read More

    Elevated PAPP-A levels in lean patients with polycystic ovary syndrome.
    Taiwan J Obstet Gynecol 2018 Jun;57(3):394-398
    Department of Obstetrics & Gynecology, Gazi University, Faculty of Medicine, Ankara, Turkey.
    Objectives: This study aimed to evaluate the serum concentrations of PAPP-A (pregnancy associated placental protein-A), a biomarker which is associated with cardiovascular disease, in patients with polycystic ovary syndrome (PCOS).

    Materials And Methods: A total of 62 women with PCOS, and 68 age and body mass index (BMI) matched controls were eligible for the study. Hirsutism scores, hormonal and metabolic profile as well as PAPP-A levels were assessed in each subject. Read More

    Long-Term Response of Hirsutism and Other Hyperandrogenic Symptoms to Combination Therapy in Polycystic Ovary Syndrome.
    J Womens Health (Larchmt) 2018 Jun 7. Epub 2018 Jun 7.
    2 Department of Obstetrics and Gynecology, Medical College of Georgia, Augusta University, Augusta, Georgia .
    Background: Polycystic ovary syndrome (PCOS) affects 5%-15% of women and is the most common cause of hirsutism. Data on the time-course of improvement to suppressive therapy and predictors of that response in PCOS are lacking. The objectives of our study are to determine the long-term response and identify predictors of response in PCOS women treated with suppressive therapy, including spironolactone (SPL) + oral contraceptives (OCs). Read More

    Effects of exercise and dietary habits on the occurrence of polycystic ovary syndrome over 5 years of follow-up.
    Int J Gynaecol Obstet 2018 Jun 7. Epub 2018 Jun 7.
    Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
    Objective: To evaluate the effects of recent and previous exercise and dietary habits on the occurrence of polycystic ovary syndrome (PCOS).

    Methods: The present study had a population-based case-control phase and a nested case-control phase. Women aged 12-44 years with and without PCOS were surveyed using the Semiquantitative Food Frequency Questionnaire and the International Physical Activity Questionnaire to evaluate the correlation of PCOS with recent (last 7 days) or previous (5 years ago) exercise and dietary habits. Read More

    A Cross-sectional Study on the Proportion of Anxiety and Depression and Determinants of Quality of Life in Polycystic Ovarian Disease.
    Indian J Psychol Med 2018 May-Jun;40(3):257-262
    Department of Psychiatry, MOSC Medical College, Ernakulam, Kerala, India.
    Background: The polycystic ovary syndrome is a disorder characterized by hyperandrogenism, ovulatory dysfunction, and polycystic ovarian morphologic features. Earlier studies have shown that depression was significantly increased in the polycystic ovarian disease (PCOD) group and also that PCOD women had marked reduction in quality of life, impaired emotional well-being, and reduced sexual satisfaction. This study was undertaken with the objectives of studying the proportion of anxiety and depression and assessing the quality of life and its correlates in women with PCOD. Read More

    Anxiety, Depression, and Quality of Life in Women with Polycystic Ovarian Syndrome.
    Indian J Psychol Med 2018 May-Jun;40(3):239-246
    Department of Psychiatry, Bhabha Atomic Research Centre Hospital, Mumbai, Maharashtra, India.
    Background: Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder among women of reproductive age. Symptoms include amenorrhea, hirsutism, infertility, obesity, acne vulgaris, and androgenic alopecia. PCOS is a stigmatizing condition that affects a woman's identity, mental health and quality of life (QOL). Read More

    NASH in Nondiabetic Endocrine Disorders.
    Metab Syndr Relat Disord 2018 Jun 6. Epub 2018 Jun 6.
    1 Department of Internal Medicine, University of California , Davis, Sacramento, California.
    Nonalcoholic fatty liver disease (NAFLD) encompasses a spectrum of disease, including hepatic steatosis, inflammation, and fibrosis. NAFLD carries the risk of progression to cirrhosis with its associated complications and hepatocellular carcinoma. It is now the most common liver disease in the Western world and its prevalence is increasing. Read More

    Plasma prolidase levels as a biomarker for polycystic ovary syndrome.
    Biomark Med 2018 Jun 6. Epub 2018 Jun 6.
    Centre for Medical Biotechnology, Maharshi Dayanand University, Rohtak 124001, India.
    Aim: Assessment of plasma prolidase levels in polycystic ovary syndrome (PCOS).

    Patients & Methods: PCOS patients were screened according to Rotterdam Criterion and prolidase levels were measured.

    Results:  A total of 170 patients and 160 controls were recruited for the study and it was found that prolidase levels were significantly higher in PCOS group (991. Read More

    Antimüllerian hormone as a risk factor for miscarriage in naturally conceived pregnancies.
    Fertil Steril 2018 Jun 2. Epub 2018 Jun 2.
    Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, North Carolina.
    Objective: To determine the association between antimüllerian hormone (AMH), a measure of ovarian reserve, and miscarriage among naturally conceived pregnancies.

    Design: Prospective cohort study.

    Setting: Not applicable. Read More

    Decreased pregnancy and live birth rates after vitrification of in vitro matured oocytes.
    J Assist Reprod Genet 2018 Jun 4. Epub 2018 Jun 4.
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, McGill University Health Care Centre, 888 Boulevard de Maisonneuve E no. 200, Montreal, QC, H2L 4S8, Canada.
    Purpose: To assess effects on fertilization rate, embryo quality, pregnancy, and live birth rates of vitrification and warming of oocytes that matured in vitro (vIVM) compared to fresh in vitro maturation (fIVM) cycles.

    Methods: A retrospective cohort study conducted at a university hospital-affiliated IVF unit. Fifty-six cycles of vIVM cycles and 263 fIVM in women diagnosed with polycystic ovarian syndrome (PCOS) ovaries were included in the analysis. Read More

    Influence of tumour suppressor gene (TP53, BRCA1 and BRCA2) polymorphisms on polycystic ovary syndrome in South Indian women.
    Eur J Obstet Gynecol Reprod Biol 2018 May 24;227:13-18. Epub 2018 May 24.
    Department of Biochemistry, Osmania University, Hyderabad, India. Electronic address:
    Objective: Polycystic Ovary Syndrome (PCOS) is a heterogeneous multifactorial endocrine metabolic disorder. In addition to hyperandrogenism, acne, hirsutism, obesity, oligoanovulation and infertility, insulin resistance is also a common feature in women of PCOS. Tumor suppressor genes (TSGs) perform essential function in the maintenance of genomic stability and regulatory pathways influencing the activity of several replication and transcription factors. Read More

    Do inositol supplements enhance phosphatidylinositol supply and thus support endoplasmic reticulum function?
    Br J Nutr 2018 Jun 3:1-16. Epub 2018 Jun 3.
    School of Biosciences,University of Birmingham,Edgbaston,Birmingham B15 2TT,UK.
    This review attempts to explain why consuming extra myoinositol (Ins), an essential component of membrane phospholipids, is often beneficial for patients with conditions characterised by insulin resistance, non-alcoholic fatty liver disease and endoplasmic reticulum (ER) stress. For decades we assumed that most human diets provide an adequate Ins supply, but newer evidence suggests that increasing Ins intake ameliorates several disorders, including polycystic ovary syndrome, gestational diabetes, metabolic syndrome, poor sperm development and retinopathy of prematurity. Proposed explanations often suggest functional enhancement of minor facets of Ins Biology such as insulin signalling through putative inositol-containing 'mediators', but offer no explanation for this selectivity. Read More

    The influences of vitamin D and omega-3 co-supplementation on clinical, metabolic and genetic parameters in women with polycystic ovary syndrome.
    J Affect Disord 2018 May 26;238:32-38. Epub 2018 May 26.
    Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, IR, Iran. Electronic address:
    Objective: The aim of this study was to evaluate the effect of the co-administration of vitamin D and omega-3 fatty acid on clinical, metabolic and genetic parameters in women with polycystic ovary syndrome (PCOS).

    Methods: This randomized, double-blinded, placebo-controlled clinical trial was conducted on 60 subjects, aged 18-40 years old with PCOS. Subjects were randomly allocated to take either 50,000 IU vitamin D every 2 weeks plus 2000 mg/day omega-3 fatty acid from fish oil (n = 30) or placebo (n = 30) for 12 weeks. Read More

    Hypomethylation of specific CpG sites in the promoter region of steroidogeneic genes (GATA6 and StAR) in prenatally androgenized rats.
    Life Sci 2018 May 30. Epub 2018 May 30.
    Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences (RIES), Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran. Electronic address:
    Introduction: The methylation level of promoters is one of the most studied and well-known epigenetic mechanisms that programs the amount of gene expression. Over expression of steroidogenesis genes via epigenetic control can result in hypetandrogenism, which is the main endocrine aspect of polycystic ovarian syndrome (PCOS).

    Aims: In the present study we aimed to determine and compare the promoter methylation levels of three steroidogenic genes, CYP17, GATA6 and StAR, in theca cells of prenatally androgenized (PNA) rats to those of controls. Read More

    Chronic stress and body composition disorders: implications for health and disease.
    Hormones (Athens) 2018 Mar 27;17(1):33-43. Epub 2018 Apr 27.
    Choremeion Research Laboratory, First Department of Pediatrics, Medical School, National and Kapodistrian University of Athens, Thivon and Levadeias streets, Goudi, 11527, Athens, Greece.
    Recent studies have suggested that body composition is key to health and disease. First, fat tissue is a complex, essential, and highly active metabolic and endocrine organ that responds to afferent signals from traditional hormone systems and the central nervous system but also expresses and secretes factors with important endocrine, metabolic, and immune functions. Second, skeletal muscle mass is an important predictor of health in adult life, while severe mass loss has been associated with the frailty of old age. Read More

    Polycystic ovary syndrome and risk factors for gestational diabetes.
    Endocr Connect 2018 Jun 1. Epub 2018 Jun 1.
    L Morin-Papunen, PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.
    Objective: To study the roles of self-reported symptoms and/or prior diagnosis of polycystic ovary syndrome (PCOS) and other potential risk factors for gestational diabetes mellitus (GDM) and to clarify whether the screening of GDM in early pregnancy is beneficial for all women with PCOS.

    Design: The FinnGeDi multicentre case-control study including 1146 women with singleton pregnancies diagnosed with GDM and 1066 non-diabetic pregnant women. There were 174 women with PCOS (symptoms and/or diagnosis self-reported by a questionnaire) and 1767 women without PCOS (data missing for 271). Read More

    In-utero exposure to metformin for type 2 diabetes or polycystic ovary syndrome: A prospective comparative observational study.
    Reprod Toxicol 2018 May 29. Epub 2018 May 29.
    The Hebrew University Hadassah Medical School, Jerusalem, Israel.
    Objective: To evaluate the rate of major anomalies after first trimester (T1)-metformin exposure.

    Design: Comparative, observational cohort study done at the Israeli Teratology Information Service between 2000 and 2013.

    Results: 170 T1-metformin-exposed pregnancies [119 for diabetes and 51 for polycystic ovary syndrome (PCOS)] were prospectively followed-up and compared with 93 pregnancies of T1-insulin treated women and 530 non-teratogenic exposed (NTE) pregnancies. Read More

    Intrauterine exposure to metformin: Evaluation of endothelial and perivascular adipose tissue function in abdominal aorta of adult offspring.
    Life Sci 2018 May 28. Epub 2018 May 28.
    Department of Physiological Sciences, Biological Sciences Center, State University of Londrina, Brazil. Electronic address:
    The biguanide metformin (MET) has been used during pregnancy for treatment of polycystic ovary syndrome and gestational diabetes. MET crosses the placenta and maternal treatment can expose the progeny to this drug during important phases of body development. Direct vascular protective effects have been described with the treatment of metformin. Read More

    Simplified 4-item criteria for polycystic ovary syndrome: A bridge too far?
    Clin Endocrinol (Oxf) 2018 May 30. Epub 2018 May 30.
    Department of Obstetrics and Gynaecology, National University of Singapore, Singapore, Singapore.
    Objectives: Although the Rotterdam 2003 polycystic ovarian syndrome (PCOS) diagnostic criteria is widely used, the need to consider multiple variables makes it unwieldy in clinical practice. We propose a simplified PCOS criteria wherein diagnosis is made if two of the following three items were present: (i) oligomenorrhoea, (ii) anti-mullerian hormone (AMH) above threshold and/or (iii) hyperandrogenism defined as either testosterone above threshold and/or the presence of hirsutism.

    Design Setting And Participants: This prospective cross-sectional study consists of healthy women (n = 157) recruited at an annual hospital health screen for staff and volunteers from the university community, and a patient cohort (n = 174) comprising women referred for suspected PCOS. Read More

    Empty Follicle Syndrome Following GnRHa Trigger in PCOS Patients Undergoing IVF Cycles.
    J Reprod Infertil 2018 Jan-Mar;19(1):16-25
    - Department of Reproductive Medicine, Milann, The Fertility Center, A Unit of BACC Health care pvt Ltd, Karnataka, India.
    Background: The objective of this study was to analyze the incidence and the underlying mechanisms of empty follicle syndrome (EFS) occurring in gonadotropin releasing hormone agonist (GnRHa) triggered in fertilization (IVF) cycles with GnRH antagonist protocol in women with polycystic ovary syndrome (PCOS) of Indian origin. The study also intended to evaluate the cycle outcome following a rescue trigger.

    Methods: Retrospective cohort analysis of data was extracted from the hospital database of 271 PCOS patients who underwent IVF in antagonist protocol triggered with GnRHa from August 2014 to December 2016. Read More

    Malignant Transformation of Endometriosis in the Ischioanal Fossa.
    Case Rep Obstet Gynecol 2018 23;2018:5643040. Epub 2018 Apr 23.
    Division of Gynecologic Oncology, Christiana Care Health System, Newark, DE, USA.
    We present the case of a 28-year-old nulliparous female with malignant transformation of an ectopic focus of endometriosis in the right ischioanal fossa. A 28-year-old nulliparous patient with a past medical history of polycystic ovarian syndrome (PCOS) was diagnosed with endometrioid adenocarcinoma in her right ischioanal fossa. Initially, patient presented to an emergency department and underwent a CT scan of the appendix to rule out appendicitis. Read More

    rs4889 polymorphism in KISS1 gene, its effect on polycystic ovary syndrome development and anthropometric and hormonal parameters in Saudi women.
    J Biomed Sci 2018 May 30;25(1):50. Epub 2018 May 30.
    Central Laboratory, Center for Scientific and Medical Female Colleges, King Saud University, P.O. Box 22455, Riyadh, 11495, Saudi Arabia.
    Background: Kisspeptin is involved in female reproduction. This study was designed to i- estimate kisspeptin levels in women with polycystic ovary syndrome (PCOS), in comparison with controls, ii- study the correlations between kisspeptin and PCOS-related reproductive hormones, and iii- investigate the relation between KISS1 gene polymorphisms and hormone levels in women suffering from PCOS.

    Methods: The investigation was a clinically designed study on 28 women with PCOS, and 30 normal, healthy women with no signs of PCOS as controls. Read More

    Pharmacological and surgical treatment of nonreproductive outcomes in polycystic ovary syndrome: An overview of systematic reviews.
    Clin Endocrinol (Oxf) 2018 May 30. Epub 2018 May 30.
    Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Melbourne, Vic., Australia.
    Background: Polycystic ovary syndrome (PCOS) affects up to 13% women and is associated with significant complications. The quality of evidence supporting the recommendations on treatment of nonreproductive outcomes in PCOS is unknown.

    Objective: To summarize and appraise the methodological quality of systematic reviews and meta-analyses evaluating pharmacological and surgical treatments for nonreproductive outcomes in PCOS. Read More

    The value of prolactin in predicting prolactinοma in hyperprolactinaemic polycystic ovarian syndrome.
    Eur J Clin Invest 2018 May 29:e12961. Epub 2018 May 29.
    Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism (WISDEM), University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK.
    Background: To identify a serum prolactin (PRL) cut-off value indicative of a PRL-producing adenoma in women with polycystic ovarian syndrome (PCOS) and hyperprolactinaemia and characterize such patients.

    Materials And Methods: In the present retrospective case-control study, the medical records of 528 PCOS women were reviewed. Pituitary magnetic resonance imaging (MRI) was performed in PCOS patients with PRL levels ≥94. Read More

    Cardiometabolic risk in polycystic ovary syndrome.
    Endocr Connect 2018 May 29. Epub 2018 May 29.
    M Pfeifer, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
    Polycystic ovary syndrome (PCOS) is a common disorder in women of reproductive age. Besides hyperandrogenism, oligomenorrhea and fertility issues, it is associated with a high prevalence of metabolic disorders and cardiovascular risk factors. Several genetic polymorphisms have been identified for possible associations with cardiometabolic derangements in PCOS. Read More

    Progestin-primed milder stimulation with clomiphene citrate yields fewer oocytes and suboptimal pregnancy outcomes compared with the standard progestin-primed ovarian stimulation in infertile women with polycystic ovarian syndrome.
    Reprod Biol Endocrinol 2018 May 28;16(1):53. Epub 2018 May 28.
    Centre of assisted reproduction, Shanghai East Hospital, Tongji University, Shanghai, People's Republic of China.
    Background: Oral progestin has recently been used to prevent premature LH surges in ovarian stimulation, and this progestin-primed ovarian stimulation (PPOS) is effective and safe in patients with different ovarian reserves. The current data are lacking regarding how to individualize the gonadotropin dose and regimen for women with polycystic ovarian syndrome (PCOS). A retrospective cohort trial was performed to evaluate the efficacy of progestin-primed milder stimulation with clomiphene citrate (CC) compared to the standard progestin-primed ovarian stimulation (PPOS) protocol for infertile women with PCOS. Read More

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