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    14926 results match your criteria Polycystic Ovarian Syndrome

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    The diagnosis and lived experience of Polycystic Ovary Syndrome: A qualitative study.
    J Adv Nurs 2017 Mar 22. Epub 2017 Mar 22.
    Faculty of Health and Human Sciences, Plymouth University.
    Aims: To explore the impact of the diagnosis of polycystic ovary syndrome on health/ill health identity, how women experience this diagnosis and their health beliefs.

    Background: polycystic ovary syndrome is a common and heterogeneous condition, giving rise to a wide range of different health concerns. Previous research on polycystic ovary syndrome has been dominated by the medical perspective and less is known about the experiences and needs of women. Read More

    Androgen stimulates growth of mouse preantral follicles in vitro: interaction with follicle stimulating hormone and with growth factors of the TGFβ superfamily.
    Endocrinology 2017 Jan 24. Epub 2017 Jan 24.
    Institute of Reproductive & Developmental Biology, Imperial College London, Hammersmith Hospital, London W12 0NN, UK.
    Androgens are essential for the normal function of mature antral follicles but also have a role in the early stages of follicle development. Polycystic ovary syndrome (PCOS), the commonest cause of anovulatory infertility, is characterized by androgen excess and aberrant follicle development that includes accelerated early follicle growth. We have examined the effects of testosterone and dihydrotestosterone (DHT) on development of isolated mouse preantral follicles in culture with the specific aims of investigating interaction with FSH, the steroidogenic pathway and with growth factors of the TGFβ superfamily that are known to have a role in early follicle development. Read More

    LINE1 CpG-DNA Hypomethylation in Granulosa Cells and Blood Leukocytes is Associated with PCOS and Related Traits.
    J Clin Endocrinol Metab 2017 Jan 9. Epub 2017 Jan 9.
    Department of Molecular Endocrinology (P.S., S.M.); Department of Infertility and Endocrinology (A.P.); National Institute for Research in Reproductive Health; J.M. Street, Parel, Mumbai - 400012, India.
    Context: Altered global DNA methylation is indicative of epigenomic instability concerning chronic disease-states. Investigating its incidence and association with polycystic ovary syndrome (PCOS) is essential towards understanding the etiopathogenesis of this disorder.

    Objectives: To assess, global DNA methylation differences in peripheral blood leukocytes (PBLs) and cumulus granulosa cells (CGCs) of PCOS and controls and their association with PCOS and its traits. Read More

    Hyperhomocysteinemia promotes insulin resistance and adipose tissue inflammation in PCOS mice through modulating M2 macrophage polarization via estrogen suppression.
    Endocrinology 2017 Mar 15. Epub 2017 Mar 15.
    Reproductive Medical Center, Department of Obstetrics and Gynecology, Peking University Third Hospital.
    It has been shown that serum homocycteine (Hcy) levels are higher in women with polycystic ovary syndrome (PCOS). However, the specific role of hyperhomocycteinemia (HHcy) in the development of PCOS has never been reported. Adipose tissue inflammation is featured by the infiltration of macrophages that plays a critical role in the pathogenesis of glucose and insulin intolerance. Read More

    Assessing energy requirements in women with polycystic ovary syndrome: a comparison against doubly-labeled water.
    J Clin Endocrinol Metab 2017 Mar 8. Epub 2017 Mar 8.
    Pennington Biomedical Research Center, Baton Rouge, LA.
    Context: Weight loss is prescribed to offset the deleterious consequences of polycystic ovary syndrome (PCOS), but a successful intervention requires an accurate assessment of energy requirements.

    Objective: Describe energy requirements in women with PCOS and evaluate common prediction equations compared to doubly-labeled water (DLW).

    Design: Cross-sectional study. Read More

    The steroid metabolome in the isolated ovarian follicle and its response to androgen exposure and antagonism.
    Endocrinology 2017 Feb 23. Epub 2017 Feb 23.
    Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom.
    The ovarian follicle is a major site of steroidogenesis, crucially required for normal ovarian function and female reproduction. Our understanding of androgen synthesis and metabolism in the developing follicle has been limited by sensitivity and specificity issues of previously used assays. Here we used liquid chromatography-tandem mass spectrometry to map the stage-dependent endogenous steroid metabolome in an encapsulated in vitro follicle growth system, from murine secondary through antral follicles. Read More

    Psychological Distress Is More Prevalent in Fertile Age and Premenopausal Women with PCOS Symptoms -15-yr Follow-up.
    J Clin Endocrinol Metab 2017 Feb 27. Epub 2017 Feb 27.
    Department of Obstetrics and Gynecology, University Hospital of Oulu, University of Oulu, Medical Research Center Oulu and PEDEGO Research Unit, Oulu, Kajaanintie 50, 90014, Oulu, Finland.
    Context: Polycystic ovary syndrome (PCOS) is associated with increased psychological distress; obesity and hyperandrogenism being suggested as key promoters.

    Objectives: To investigate the prevalence of anxiety/depression and their coexistence in women with PCOS/PCOS symptoms at ages 31 and 46. The roles of obesity, hyperandrogenism and awareness of PCOS on psychological distress were also assessed. Read More

    Resveratrol inhibits androgen production of human adrenocortical H295R cells by lowering CYP17 and CYP21 expression and activities.
    PLoS One 2017 21;12(3):e0174224. Epub 2017 Mar 21.
    Division of Pediatric Endocrinology, Department of Pediatrics and Department of Clinical Research, University of Bern, Bern, Switzerland.
    Resveratrol, a natural compound found in grapes, became very popular for its suggested protective effects against aging. It was reported to have similar positive effects on the human metabolism as caloric restriction. Recently, positive effects of resveratrol on steroid biosynthesis in cell systems and in humans suffering from polycystic ovary syndrome have also been reported, but the exact mechanism of this action remains unknown. Read More

    Neuroendocrine androgen action is a key extraovarian mediator in the development of polycystic ovary syndrome.
    Proc Natl Acad Sci U S A 2017 Mar 20. Epub 2017 Mar 20.
    Andrology Laboratory, ANZAC Research Institute, University of Sydney, Sydney, NSW 2139, Australia;
    Polycystic ovary syndrome (PCOS) is a complex hormonal disorder characterized by reproductive, endocrine, and metabolic abnormalities. As the origins of PCOS remain unknown, mechanism-based treatments are not feasible and current management relies on treatment of symptoms. Hyperandrogenism is the most consistent PCOS characteristic; however, it is unclear whether androgen excess, which is treatable, is a cause or a consequence of PCOS. Read More

    Effect of the R92H and A379V genotypes of platelet-activating factor acetylhydrolase on its enzyme activity, oxidative stress and metabolic profile in Chinese women with polycystic ovary syndrome.
    Lipids Health Dis 2017 Mar 20;16(1):57. Epub 2017 Mar 20.
    Laboratory of Genetic Disease and Perinatal Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, 610041, People's Republic of China.
    Background: The G994T polymorphism in platelet-activating factor acetylhydrolase (PAF-AH) gene is associated with the risk of polycystic ovary syndrome (PCOS). The aim of this study was to investigate the relationship between R92H and A379V variants of the PAF-AH gene and the risk of PCOS and to evaluate the effects of the genotypes on PAF-AH activities and clinical, metabolic and oxidative stress indexes in Chinese women.

    Methods: A total of 862 patients with PCOS based on the Rotterdam consensus criteria and 750 control women from a population of Chinese Han nationality in the Chengdu area were studied from 2006-2015. Read More

    Prevalence of Methylenetetrahydrofolate Reductase C677T Polymorphism in women with Polycystic Ovary Syndrome in southeast of Iran.
    J Med Life 2015 ;8(Spec Iss 3):229-232
    Department of Obstetrics and Gynecology, Faculty of Medical Sciences, Shahid Beheshti University, Tehran, Iran.
    Background: One of the notable enzymes in the metabolism of folate is Methylenetetrahydrofolate reductase enzyme, this enzyme is necessary for some biological mechanisms. Mutations in the MTHFR gene could reduce the enzyme activity. Aim: The objective of this research was to assess the prevalence of the very general polymorphism, C677T, in females with polycystic ovary syndrome in the southeastern of Iran. Read More

    Assessment of circulating betatrophin concentrations in lean glucose-tolerant women with polycystic ovary syndrome.
    J Obstet Gynaecol 2017 Mar 20:1-6. Epub 2017 Mar 20.
    b Department of Biochemistry , Antalya Training and Research Hospital , Antalya , Turkey.
    The aims of the current study were to investigate the betatrophin levels in lean glucose-tolerant women with polycystic ovary syndrome (PCOS), and to explore the relationships between these levels and antropometric, hormonal and metabolic parameters. The study population consisted of 50 lean (body mass index [BMI] < 25 kg/m(2)) women diagnosed with PCOS using the Rotterdam criteria, and 60 age- and BMI-matched healthy controls without any features of clinical or biochemical hyperandrogenism. Before recruitment, glucose tolerance was evaluated in all of the subjects using the 2-h 75 g oral glucose-tolerance test, and only those exhibiting normal glucose tolerance were enrolled. Read More

    The effects of DASH diet on weight loss, anti-Müllerian hormone and metabolic profiles in women with polycystic ovary syndrome: a randomized clinical trial.
    Clin Endocrinol (Oxf) 2017 Mar 18. Epub 2017 Mar 18.
    Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I.R. Iran.
    Objective: This study was designed to evaluate the effects of the Dietary Approaches to Stop Hypertension (DASH diet) on weight loss, anti-Müllerian hormone (AMH) and metabolic profiles in women with polycystic ovary syndrome (PCOS).

    Design, Patients And Measurements: A randomized controlled clinical trial was conducted among 60 overweight or obese patients with PCOS. Patients were randomly assigned to receive either low-calorie DASH (N=30) or control diet (N=30) for 12 weeks. Read More

    Serum Level of Zinc and Copper in Sudanese Women with Polycystic Ovarian Syndrome.
    Biol Trace Elem Res 2017 Mar 18. Epub 2017 Mar 18.
    Faculty of Medicine, Al-Neelain University, P.O Box 12702, 11111, Khartoum, Sudan.
    The study aimed to evaluate the serum level of zinc and copper in women with polycystic ovarian syndrome (PCOS). A case-control study was conducted at Saad Abualila infertility center (Khartoum, Sudan). The cases were women who had a PCOS based on Rotterdam criteria. Read More

    Heart rate variability in normal-weight patients with polycystic ovary syndrome.
    Anatol J Cardiol 2017 Mar 9. Epub 2017 Mar 9.
    Department of Cardiology, Faculty of Medicine, Dumlupınar University; Kütahya-Turkey.
    Objective: Polycystic ovary syndrome (PCOS) is an endocrine disease closely related to several risk factors of cardiovascular disease. Obese women with PCOS show altered autonomic modulation. The results of studies investigating cardiac autonomic functions of normal-weight women with PCOS are conflicting. Read More

    Studies on the quality nutrition in women with polycystic ovary syndrome (PCOS)
    Rocz Panstw Zakl Hig 2017 ;68(1):61-67
    Independent Laboratory of Medical Education, Faculty of Health Sciences, Pomeranian Medical University in Szczecin, Poland
    Background: Polycystic ovary syndrome (PCOS) manifests itself with various symptoms, therefore it interests representatives of many medical specializations: general practitioners, gynecologists, endocrinologists, dermatologists, cardiologists and those who deal with metabolic disorders, such as dieticians.

    Objective: The aim of this study was perform the qualitative assessment of components of diets of women with PCOS as one of the major factor contributing to the disease.

    Material And Methods: The study was performed on 54 women of childbearing age with PCOS diagnosed according to on the Rotterdam criteria. Read More

    Expression Patterns and Correlations with Metabolic Markers of Zinc Transporters ZIP14 and ZNT1 in Obesity and Polycystic Ovary Syndrome.
    Front Endocrinol (Lausanne) 2017 2;8:38. Epub 2017 Mar 2.
    Faculty of Health, Department of Biomedicine, Aarhus University , Aarhus , Denmark.
    Polycystic ovary syndrome (PCOS) is associated with infertility, increased androgen levels, and insulin resistance. In adipose tissue, zinc facilitates insulin signaling. Circulating zinc levels are altered in obesity, diabetes, and PCOS; and zinc supplementation can ameliorate metabolic disturbances in PCOS. Read More

    Serum visfatin, vascular endothelial growth factor and matrix metalloproteinase-9 in women with polycystic ovary syndrome.
    Gynecol Endocrinol 2017 Mar 16:1-5. Epub 2017 Mar 16.
    a First Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki , Thessaloniki , Greece.
    Aim: To evaluate serum concentrations of visfatin, vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) in women with polycystic ovary syndrome (PCOS) and to investigate their possible role as early endothelial markers in PCOS.

    Methods: Forty-two women with PCOS and 42 controls, matched for age and weight, were included in the study. Serum concentrations of follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin, total testosterone (tT), Δ4-androstenedione (Δ4A), dehydroepinadrosterone sulphate (DHEA-S), 17-OH-progesterone, sex hormone-binding protein (SHBG), thyroid-stimulating hormone (TSH), free thyroxine (fT4), visfatin, VEGF and MMP-9 were measured in all women; free androgen index (FAI) was calculated as well. Read More

    Developmental Programming.
    Reprod Sci 2017 Jan 1:1933719117697127. Epub 2017 Jan 1.
    1 Department of Pediatrics, University of Michigan, Ann Arbor, MI, USA.
    Prenatal testosterone (T)-treated sheep, similar to women with polycystic ovary syndrome (PCOS), manifests reproductive defects that include multifollicular ovarian phenotype. Women with PCOS manifest increased ovarian matrix metalloproteinases (MMPs) activity. We tested the hypothesis that gestational T excess in sheep would alter ovarian expression of MMPs, tissue inhibitors of MMP (TIMP) and their target proteins laminin B (LAMB), collagen, tumor necrosis factor alpha (TNF), and connexin 43 (GJA1) consistent with increased MMP activity and that these changes are developmentally regulated. Read More

    Association study of HNF1A in women with polycystic ovary syndrome.
    J Assist Reprod Genet 2017 Mar 15. Epub 2017 Mar 15.
    Center for Reproductive Medicine, Shandong University, No.157, Jingliu Road, Jinan, 250021, China.
    Purpose: This study aims to ascertain whether an association exists between hepatocyte nuclear factor 1 alpha (HNF1A) and polycystic ovary syndrome (PCOS).

    Methods: One thousand one hundred thirty-eight PCOS and 1125 healthy control Han Chinese women were recruited from Reproductive Hospital Affiliated to Shandong University. Serum hormone, blood lipid level, and genomic DNA were obtained from the peripheral blood for this research. Read More

    The anti-inflammatory protein kallistatin is associated with carotid intima media thickness in women with polycystic ovary syndrome.
    Minerva Endocrinol 2017 Mar 14. Epub 2017 Mar 14.
    Department of Internal Medicine, Izmir Bozyaka Training and Research Hospital, Bozyaka, Izmir, Turkey.
    Background: Kallistatin is a secreted protein that acts as a tissue kallikrein inhibitor. It has antiinflammatory, antioxidant and vasoprotective properties. Polycystic ovary syndrome (PCOS) is a reproductive and metabolic disease associated with low-grade chronic inflammation and multiple risk factors for cardiovascular diseases. Read More

    Dysbiosis of Gut Microbiota Associated with Clinical Parameters in Polycystic Ovary Syndrome.
    Front Microbiol 2017 28;8:324. Epub 2017 Feb 28.
    Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine Shanghai, China.
    Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder in women. Gut microbiota has been implicated to play a critical role in metabolic diseases and may modulate the secretion of mediators of the brain-gut axis. Interaction between gut microbiota and the endocrine and biochemical disturbances in PCOS still remains elusive. Read More

    Obesity and female infertility: potential mediators of obesity's impact.
    Fertil Steril 2017 Mar 11. Epub 2017 Mar 11.
    Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri. Electronic address:
    The worldwide upward trend in obesity has been dramatic, now affecting more than 20% of American women of reproductive age. Obesity is associated with many adverse maternal and fetal effects prenatally, but it also exerts a negative influence on female fertility. Obese women are more likely to have ovulatory dysfunction due to dysregulation of the hypothalamic-pituitary-ovarian axis. Read More

    Choosing the Right Oral Contraceptive Pill for Teens.
    Pediatr Clin North Am 2017 Apr;64(2):343-358
    Division of Adolescent Medicine, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA. Electronic address:
    Oral contraceptive pills (OCPs) continue to be the most commonly used form of prescription contraceptives used by adolescents in the United States. With proper use, oral contraceptives provide safe and effective birth control. Broad categories of OCPs include progestin-only pills (POPs) and combined oral contraceptive pills (COCs). Read More

    Restored Plasma Anandamide and Endometrial Expression of Fatty Acid Amide Hydrolase in Women With Polycystic Ovary Syndrome by the Combination Use of Diane-35 and Metformin.
    Clin Ther 2017 Mar 10. Epub 2017 Mar 10.
    Department of Reproduction, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
    Purpose: Polycystic ovary syndrome (PCOS) is a metabolic and endocrinal disorder affecting a number of women of reproductive age. We aimed to reveal the correlation between the endocannabinoid system and PCOS, which may provide a new therapeutic target for PCOS treatment.

    Methods: Serum levels of anandamide and 2-arachidonoylglycerol andexpression of cannabinoid receptors and fatty acid amide hydrolase (FAAH) in the endometrium were compared between women with PCOS and infertile women without PCOS, as well as women with PCOS before and after treatment with Diane-35 and metformin. Read More

    Cytochrome P450 oxidoreductase deficiency caused by R457H mutation in POR gene in Chinese: case report and literature review.
    J Ovarian Res 2017 Mar 14;10(1):16. Epub 2017 Mar 14.
    Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, Nanjing North Street, NO 155, Shenyang, 110001, People's Republic of China.
    Background: Cytochrome P450 oxidoreductase deficiency (PORD) is a rare disease exhibiting a variety of clinical manifestations. It can be difficult to differentiate with other diseases such as 21-hydroxylase deficiency (21-OHD), polycystic ovary syndrome (PCOS) and Antley-Bixler syndrome (ABS). Nearly 100 cases of PORD have been reported worldwide. Read More

    Increased Coagulation and Decreased Fibrinolysis as Measured with Overall Hemostatic Potential Are Dependent on BMI and Not Associated with PCOS.
    Metab Syndr Relat Disord 2017 Mar 13. Epub 2017 Mar 13.
    2 Department of Endocrinology, Diabetes and Metabolic Disease, University Medical Centre Ljubljana , Ljubljana, Slovenia .
    Background: Overall hemostatic potential (OHP) captures all factors that affect coagulation and fibrinolysis cascade. It has not yet been assessed in polycystic ovary syndrome (PCOS). The aim of the study was to identify the relationship of OHP with a syndrome per se and body mass index (BMI). Read More

    Prevalence of hypovitaminosis D and associated factors in obese Spanish children.
    Nutr Diabetes 2017 Mar 13;7(3):e248. Epub 2017 Mar 13.
    Department of Pediatrics, Navarra Hospital Complex, Pamplona, Spain.
    Background/objectives: Vitamin D deficiency may contribute to endocrine health and disease (diabetes, autoimmune thyroid diseases, polycystic ovarian syndrome, etc.). The aim of this study was to determine the prevalence and specific factors for hypovitaminosis D among children stratified by body mass index (BMI) in Northern Spain. Read More

    Consensus on the integrated traditional Chinese and Western medicine criteria of diagnostic classification in polycystic ovary syndrome (draft).
    J Integr Med 2017 Mar;15(2):102-109
    Department of Integration of Western and Traditional Chinese Medicine, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China.
    Polycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disorder of women, with complex pathogenesis and heterogeneous manifestations. Professor Jin Yu recently wrote an article entitled "Proposal of Diagnosis and Diagnostic Classification of PCOS in Integrated Traditional Chinese and Western Medicine."From this, the Obstetrics and Gynecology branches of the Chinese Association of Integrative Medicine and the China Association of Chinese Medicine collaborated with the Gynecology branch of the Chinese Association for Research and Advancement of Chinese Medicine to draft a report on the consensus of criteria for the diagnosis and classification of PCOS in integrated traditional Chinese and Western medicine. Read More

    Effectiveness of co-treatment with traditional Chinese medicine and letrozole for polycystic ovary syndrome: a meta-analysis.
    J Integr Med 2017 Mar;15(2):95-101
    The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu Province, China.
    Background: Polycystic ovary syndrome (PCOS) is an endocrine disease that affects gynecological health. Treatment of PCOS remains a big challenge for clinicians.

    Objective: This meta-analysis was developed to compare the efficacy of co-treatment with traditional Chinese medicine (TCM) and letrozole against letrozole monotherapy in the treatment of PCOS. Read More

    The role of Notch signalling in ovarian angiogenesis.
    J Ovarian Res 2017 Mar 11;10(1):13. Epub 2017 Mar 11.
    Laboratory of Microvascular Medicine, Medical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, 16766 Jingshi Road, Jinan, People's Republic of China.
    In adults, the ovary is characterized with extensive angiogenesis and regular intervals of rapid growth. Ovarian function is dependent on the network of angiogenic vessels which enable the follicle and/or corpus luteum to receive oxygen, nutrients and hormonal support. Abnormal angiogenesis is involved in the induction and development of pathological ovary, such as polycystic ovary syndrome and ovarian cancer. Read More

    Quality of life in overweight (obese) and normal-weight women with polycystic ovary syndrome.
    Patient Prefer Adherence 2017 2;11:423-429. Epub 2017 Mar 2.
    Department of Clinical Medicine and Surgery, University of Napoli Federico II, Naples, Italy.
    Objective: Polycystic ovary syndrome (PCOS) is characterized by phenotypic heterogeneity and has a wide variety of consequences. Approximately half of women with PCOS are overweight or obese, and their obesity may be a contributing factor to PCOS pathogenesis through different mechanisms. The aim of this study was to evaluate if PCOS alone affects the patients' quality of life and to what extent obesity contributes to worsen this disease. Read More

    Genetic variant in vitamin D-binding protein is associated with metabolic syndrome and lower 25-hydroxyvitamin D levels in polycystic ovary syndrome: A cross-sectional study.
    PLoS One 2017 9;12(3):e0173695. Epub 2017 Mar 9.
    Gynecological Endocrinology Unit, Division of Endocrinology, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil.
    Vitamin D deficiency has been related to metabolic syndrome (MetS) in polycystic ovary syndrome (PCOS). The vitamin D-binding protein (DBP) is the main protein involved in vitamin D transport. Two single-nucleotide polymorphisms (SNPs) of the DBP gene, rs4588 and rs7041, have been associated with low circulating levels of 25-hydroxyvitamin D [25(OH)D] in various populations, but not in women with PCOS. Read More

    Oral carnitine supplementation influences mental health parameters and biomarkers of oxidative stress in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial.
    Gynecol Endocrinol 2017 Feb 21:1-6. Epub 2017 Feb 21.
    e Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences , Kashan , Iran.
    Introduction: Limited data are available assessing the effects of oral carnitine supplementation on mental health parameters and biomarkers of oxidative stress of women with polycystic ovary syndrome (PCOS).This study was designed to determine the effects of oral carnitine supplementation on mental health parameters and biomarkers of oxidative stress in women with PCOS.

    Methods: In the current randomized, double-blind, placebo-controlled trial, 60 patients diagnosed with PCOS were randomized to take either 250 mg carnitine supplements (n = 30) or placebo (n = 30) for 12 weeks. Read More

    The role of nesfatin-1 expression in letrozole-induced polycystic ovaries in the rat.
    Gynecol Endocrinol 2017 Feb 21:1-4. Epub 2017 Feb 21.
    b Department of Reproductive Medicine , Binzhou Medical University Hospital , Binzhou , China.
    Polycystic ovary syndrome (PCOS) is a complex and heterogeneous endocrine disorder, generally exhibiting the characteristic features of hyperandrogenemia, insulin resistance (IR) and obesity. Nesfatin-1 is derived from the precursor nucleobindin2 (NUCB2), and plays an active role in energy balance, glucose metabolism and most likely gonadal function. In order to explore the role of nesfatin-1, we employed a rat model that uses letrozole to induce PCOS. Read More

    Low birth-weight is a PCOS risk factor for Southern-Italian women.
    Gynecol Endocrinol 2017 Feb 21:1-5. Epub 2017 Feb 21.
    a Institute of Obstetric and Gynecological Pathology, Santo Bambino Hospital, University of Catania , Catania , Italy.
    Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine and metabolic disorder, characterized by chronic anovulation/oligomenorrhea, hyperandrogenism and insulin-resistance. Initial studies on the genetic basis of this disorder suggested both a maternal and paternal pattern of inheritance. Birth weight has become a main factor to consider when investigating the etiology of an adult-onset disease, since it is a simple indicator of intrauterine adverse conditions. Read More

    Daytime decrease of prolactin levels is associated with PCOS regardless to nutritional status and other hormones levels.
    Gynecol Endocrinol 2017 Feb 21:1-6. Epub 2017 Feb 21.
    d Department of Pathophysiology, Health Promotion and Obesity Management Unit , Medical University of Silesia , Katowice , Poland.
    Objective: The aim of the study is to analyze daytime changes of prolactin level depending on nutritional status and polycystic ovary syndrome (PCOS).

    Study Design: One hundred and fifteen (69 normal weight, 21 overweight and 25 obese) diagnosed with PCOS and 77 (37 normal weight, 18 overweight and 22 obese) women - Non-PCOS without concomitant diseases were enrolled. Body mass and height were measured and BMI was calculated. Read More

    Alteration in follistatin gene expression detected in prenatally androgenized rats.
    Gynecol Endocrinol 2017 Feb 26:1-5. Epub 2017 Feb 26.
    a Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences (RIES), Shahid Beheshti University of Medical Sciences , Tehran , Iran.
    Impaired ovarian follicle development, the hallmark of polycystic ovarian syndrome (PCOS), is believed to be due to the changes in expression of related genes such as follistatin (FST). Expression of FST gene and methylation level of its promoter in theca cells from adult female rats, prenatally exposed to androgen excess, during different phases of the estrus cycle was determined and compared with controls. Eight pregnant Wistar rats (experimental group) were treated by subcutaneous injection of 5 mg free testosterone on day 20 of pregnancy, while controls (n = 8) received 500 ml solvent. Read More

    Letrozole combined with low dose highly purified HMG for ovulation induction in clomiphene citrate-resistant infertile Chinese women with polycystic ovary syndrome: a prospective study.
    Gynecol Endocrinol 2017 Feb 28:1-5. Epub 2017 Feb 28.
    a Department of Gynecological Endocrinology , Beijing Obstetrics and Gynecology Hospital, Capital Medical University , Beijing , PR China and.
    Background And Aim: There are still open questions about ovulation induction in clomiphene citrate-(CC)-resistant infertile women. Especially little is known about efficacy and safety of letrozole (LTZ) combined with low-dose highly purified human menopausal gonadotropin (Hp-HMG) in women with polycystic ovary syndrome (PCOS).

    Methods: Prospective, single-arm single-center trial in 200 infertile PCOS patients refractory for at least three CC-treatment cycles. Read More

    Valuable predictors of gestational diabetes mellitus in infertile Chinese women with polycystic ovary syndrome: a prospective cohort study.
    Gynecol Endocrinol 2017 Feb 28:1-4. Epub 2017 Feb 28.
    a Department of Reproductive Endocrinology , Obstetrics and Gynecology Hospital, Fudan University and Shanghai Key Laboratory of Female Reproductive Endocrine Related Disease , Shanghai , China and.
    Objective: This study aimed to explore valuable preconception predictors of gestational diabetes mellitus (GDM) in PCOS patients.

    Methods: A prospective cohort study enrolling infertile Chinese PCOS women treated with ovulation induction was performed. The endocrine, metabolic and physical features of all the patients were collected before pregnancy and then followed up to 6 weeks after delivery. Read More

    Structural imaging of the brain reveals decreased total brain and total gray matter volumes in obese but not in lean women with polycystic ovary syndrome compared to body mass index-matched counterparts.
    Gynecol Endocrinol 2017 Mar 1:1-5. Epub 2017 Mar 1.
    a Department of Internal Medicine , Hacettepe University School of Medicine , Ankara , Turkey.
    Purpose: To detect differences in global brain volumes and identify relations between brain volume and appetite-related hormones in women with polycystic ovary syndrome (PCOS) compared to body mass index-matched controls.

    Methods: Forty subjects participated in this study. Cranial magnetic resonance imaging and measurements of fasting ghrelin, leptin and glucagon-like peptide 1 (GLP-1), as well as GLP-1 levels during mixed-meal tolerance test (MTT), were performed. Read More

    Myo-inositol administration positively effects ovulation induction and intrauterine insemination in patients with polycystic ovary syndrome: a prospective, controlled, randomized trial.
    Gynecol Endocrinol 2017 Mar 3:1-5. Epub 2017 Mar 3.
    b Department of Obstetrics and Gynecology , Dokuz Eylul University, School of Medicine , Izmir , Turkey.
    Objectıve: The aim of the study is to investigate the effect of myo-inositol (MYO) on pregnancy rates of patients diagnosed with polycystic ovary syndrome (PCOS) who undergone controlled ovulation induction and intrauterine insemination (IUI).

    Methods: A total of 196 infertile patients diagnosed with PCOS and admitted to Dokuz Eylul University Faculty of Medicine were included in the study between March 2013 and May 2016. The patients in group 1 (n = 98) were given 4 g MYO and 400 μg folic acid before and during ovulation induction. Read More

    GLP-1 receptor agonists in the treatment of polycystic ovary syndrome.
    Expert Rev Clin Pharmacol 2017 Apr 13;10(4):401-408. Epub 2017 Feb 13.
    b Department of Medicine , University of Maryland Medical Center , Baltimore , MD , USA.
    Introduction: Polycystic ovarian syndrome (PCOS) affects many women of child-bearing age and is characterized by hyperandrogenism, ovulatory and metabolic dysfunction. A primary treatment goal is weight reduction. The weight loss effects of glucagon-like peptide-1 receptor agonists (GLP-1RA), previously demonstrated in diabetic and obese non-diabetic patients, offer a unique opportunity to expand the medical options available to PCOS patients. Read More

    Evaluation of serum hepcidin and iron levels in patients with PCOS: a case-control study.
    J Endocrinol Invest 2017 Mar 8. Epub 2017 Mar 8.
    Vali-e-Asr Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran.
    Purpose: Polycystic ovary syndrome (PCOS) is the most common cause of chronic anovulation with a prevalence of 5-10% in women of reproductive age. The etiology of this disease is not well known, and hepcidin is one of the factors affecting the pathogenesis of the disease. The aim of this study was to evaluate plasma levels of hepcidin in patients with PCOS and its correlation with serum iron level. Read More

    Association between periodontal disease and polycystic ovary syndrome: a systematic review.
    Int J Impot Res 2017 Mar 9. Epub 2017 Mar 9.
    Department of General Dentistry, Eastman Institute for Oral Health, University of Rochester, Rochester, NY, USA.
    The purpose of the present study was to review systematically the association between periodontal diseases (PDs) and polycystic ovary syndrome (PCOS). To address the focused question, 'Is there a relationship between PD and PCOS?' indexed databases were searched up to October 2016 without time or language restrictions using different combinations of the following key words: PCOS, ovarian cysts, PD, periodontitis, gingival diseases and gingivitis. Letters to the Editor, commentaries, historic reviews, case-report, unpublished articles and animal/experimental studies were excluded. Read More

    Hormonal therapies for acne.
    Clin Dermatol 2017 Mar - Apr;35(2):168-172. Epub 2016 Oct 27.
    Department of Dermatology, College of Medicine, The Pennsylvania State University, Hershey, PA, USA.
    Acne is a common, worldwide problem that is usually multifactorial in etiology, but androgens may play a pivotal role in the development and severity of acne. Endocrinopathies, such as polycystic ovarian syndrome, ovarian tumors, or adrenal hyperplasia or tumors, may be detected in some patients with acne, especially if acne is sudden in onset, associated with hirsutism or menstrual irregularities, or associated with cushingoid facies, acanthosis nigricans, patterned hair loss, or deepened voice. In these instances, serum-free and total testosterone, dehydroepiandrosterone, luteinizing hormone, and follicle stimulating hormone should be tested. Read More

    Sex hormones and acne.
    Clin Dermatol 2017 Mar - Apr;35(2):130-137. Epub 2016 Oct 27.
    IZZ-Immunologie Zentrum Zürich, Walchestr. 11, CH 8006, Zürich, Switzerland; Department of Dermatology and Allergy, Technische Universität München, Biedersteinerstr. 29, D-80802, Munich, Germany. Electronic address:
    The skin is an endocrine organ with the expression of metabolizing enzymes and hormone receptors for diverse hormones. The sebaceous gland is the main site of hormone biosynthesis, especially for androgens, and acne is the classical androgen-mediated dermatosis. In sebocytes, conversion of 17-hydroxyprogesterone directly to dihydrotestosterone bypassing testosterone has been demonstrated, while type II 17β-hydroxysteroid dehydrogenase can inactivate the action of testosterone and dihydrotestosterone. Read More

    Acupuncture treatment for insulin sensitivity of women with polycystic ovary syndrome and insulin resistance: a study protocol for a randomized controlled trial.
    Trials 2017 Mar 9;18(1):115. Epub 2017 Mar 9.
    Department of Traditional Chinese Medicine, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
    Background: Our prospective pilot study of acupuncture affecting insulin sensitivity on polycystic ovary syndrome (PCOS) combined with insulin resistance (IR) showed that acupuncture had a significant effect on improving the insulin sensitivity of PCOS. But there is still no randomized controlled trial to determine the effect of acupuncture on the insulin sensitivity in women with PCOS and IR. In this article, we present the protocol of a randomized controlled trial to compare the effect of true acupuncture on the insulin sensitivity of these patients compared with metformin and sham acupuncture. Read More

    Use of electroacupuncture and transcutaneous electrical acupoint stimulation in reproductive medicine: a group consensus.
    J Zhejiang Univ Sci B 2017 Mar.;18(3):186-193
    Neuroscience Research Institute, Peking University / Department of Neurobiology, School of Basic Medical Sciences / Peking University Health Science Center / Key Lab for Neuroscience, Ministry of Education/Ministry of Health, Beijing 100083, China.
    With the rapid development of assisted reproductive technology, various reproductive disorders have been effectively addressed. Acupuncture-like therapies, including electroacupuncture (EA) and transcutaneous electrical acupoint stimulation (TEAS), become more popular world-wide. Increasing evidence has demonstrated that EA and TEAS are effective in treating gynecological disorders, especially infertility. Read More

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