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    Alteration of ghrelin/obestatin ratio in adolescence with polycystic ovarian syndrome.
    Gynecol Endocrinol 2017 Jun 24:1-4. Epub 2017 Jun 24.
    a Department of Obstetrics and Gynecology , Affiliated Hospital, Logistical College of Chinese People's Armed Police Forces , Tianjin , PR China.
    Ghrelin, an endoggenous for the growth hormone secretagogue receptor, has been shown to participate in the regulation of energy homeostasis and pituitary hormone secretion. Obestatin, encoded by the same gene as ghrelin, is described as a physiological opponent of ghrelin. Ghrelin and obestatin are altered in polycystic ovary syndrome (PCOS), which is characterized by insulin resistance and pituitary hormone secretion disorder. Read More

    Can the source of hyperandrogenism in adolescents with polycystic ovary syndrome predict metabolic phenotype?
    Gynecol Endocrinol 2017 Jun 24:1-6. Epub 2017 Jun 24.
    c Division of Pediatric and Adolescent Gynecology , Mayo Clinic , Rochester , MN , USA.
    In this study, we demonstrated an association between adrenal hyperandrogenism, as determined by dehydroepiandrostenedione-to-free testosterone (DHEA-S/FT) ratio, and metabolic phenotype in obese and lean adolescents with polycystic ovary syndrome (PCOS). We compared 64 overweight/obese adolescents with PCOS (PCOS-O) with 18 lean (PCOS-L) adolescents. We analyzed the association between DHEA-S/FT ratios and metabolic parameters. Read More

    The Value of Anti-Müllerian Hormone in Predicting Clinical Pregnancy After Intrauterine Insemination.
    J Obstet Gynaecol Can 2017 Jun 21. Epub 2017 Jun 21.
    Winthrop University Hospital, Mineola, NY, USA; Reproductive Specialists of New York, Mineola, NY, USA.
    Objectives: To evaluate the utility of anti-Müllerian hormone (AMH) in predicting clinical pregnancy with intrauterine insemination (IUI) and compare it to other markers of quantitative ovarian reserve.

    Methods: Retrospective cohort study of women undergoing natural and stimulated IUI cycles. All patients achieved a clinical pregnancy within three IUI cycles or completed three IUI cycles without pregnancy. Read More

    Insulin and the polycystic ovary syndrome.
    Diabetes Res Clin Pract 2017 Jun 12;130:163-170. Epub 2017 Jun 12.
    Clinic of Endocrinology, Diabetes and Metabolic Diseases, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
    Polycystic ovary syndrome (PCOS) is the most prevalent endocrinopathy among women during reproductive age. PCOS is characterised by hyperandrogenaemia, hyperinsulinaemia, and deranged adipokines secretion from the adipose tissue. In addition to the reduced insulin sensitivity, PCOS women exhibit β-cell dysfunction as well. Read More

    Asynchronus bilateral ovarian torsions in girls-systematic review.
    World J Pediatr 2017 Jun 22. Epub 2017 Jun 22.
    Department of Pediatric Surgery, Chelsea Children's Hospital, Chelsea, UK.
    Background: Bilateral ovarian torsions with complete loss of ovaries is devastating. This study analyzed the literature on bilateral ovarian torsions in girls to evaluate surgical options and outcomes.

    Methods: Literature was searched on Pubmed® (1987-2014) using terms "bilateral", "adnexal", "ovary", "torsion" and "children". Read More

    Validation of an automated technique for ovarian cortex dissociation: isolation of viable ovarian cells and their qualification by multicolor flow cytometry.
    J Ovarian Res 2017 Jun 23;10(1):38. Epub 2017 Jun 23.
    Centre Hospitalier Régional Universitaire Jean Minjoz, Service de Biologie et Médecine de la Reproduction - Cryobiologie, CECOS Franche-Comté Bourgogne, CIC-1431, 3 boulevard Fleming, F-25030, Besançon Cedex, France.
    Background: Ovarian tissue cryopreservation is a technique for fertility preservation addressed to prepubertal girls or to patients for whom no ovarian stimulation is possible before initiation of gonadotoxic treatments. Autotransplantation of frozen-thawed ovarian tissue is the only available option for reuse but presents some limitations: ischemic tissue damages post-transplant and reintroduction of malignant cells in cases of cancer. It is therefore essential to qualify ovarian tissue before autograft on a functional and oncological point of view. Read More

    AKR1C3-mediated adipose androgen generation drives lipotoxicity in women with polycystic ovary syndrome.
    J Clin Endocrinol Metab 2017 Jun 22. Epub 2017 Jun 22.
    Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
    Context: Polycystic ovary syndrome (PCOS) is a prevalent metabolic disorder, occurring in up to 10% of women of reproductive age. PCOS is associated with insulin resistance and cardiovascular risk. Androgen excess is a defining feature of PCOS and has been suggested as causally associated with insulin resistance; however, mechanistic evidence linking both is lacking. Read More

    Potential therapeutic applications of human anti-Müllerian hormone (AMH) analogues in reproductive medicine.
    J Assist Reprod Genet 2017 Jun 22. Epub 2017 Jun 22.
    Center for Human Reproduction, 21 East 69th Street, New York, NY, 10021, USA.
    Members of the transforming growth factor-beta (TGF-beta) superfamily are key regulators of various physiological processes. Anti-Müllerian hormone (AMH) which is also commonly known as Müllerian-inhibiting substance (MIS) is a member of the TGF-beta superfamily and an important regulator of reproductive organ differentiation and ovarian follicular development. While AMH has been used for diagnostic purposes as a biomarker for over 15 years, new potential therapeutic applications of recombinant human AMH analogues are now emerging as pharmacologic agents in reproductive medicine. Read More

    Polycystic ovary syndrome, adipose tissue and metabolic syndrome.
    Arch Gynecol Obstet 2017 Jun 22. Epub 2017 Jun 22.
    Department of Surgical, Microsurgical and Medical Sciences, Gynecologic and Obstetric Clinic, University of Sassari, 07100, Sassari, Italy.
    Purpose: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder that affects women of reproductive age and is characterized by ovulatory dysfunction and/or androgen excess or polycystic ovaries. Women with PCOS present a number of systemic symptoms in addition to those related to the reproductive system. It has been associated with functional derangements in adipose tissue, metabolic syndrome, type 2 diabetes, and an increased risk of cardiovascular disease (CVD). Read More

    Polycystic Ovary Syndrome: Insights into the Therapeutic Approach with Inositols.
    Front Pharmacol 2017 8;8:341. Epub 2017 Jun 8.
    Pharmacology Section, Department of Biomedical and Biotechnological Sciences, School of Medicine, Catania UniversityCatania, Italy.
    Polycystic ovary syndrome (PCOS) is characterized by hormonal abnormalities that cause menstrual irregularity and reduce ovulation rate and fertility, associated to insulin resistance. Myo-inositol (cis-1,2,3,5-trans-4,6-cyclohexanehexol, MI) and D-chiro-inositol (cis-1,2,4-trans-3,5,6-cyclohexanehexol, DCI) represent promising treatments for PCOS, having shown some therapeutic benefits without substantial side effects. Because the use of inositols for treating PCOS is widespread, a deep understanding of this treatment option is needed, both in terms of potential mechanisms and efficacy. Read More

    Obstructive Sleep Apnoea and Polycystic Ovary Syndrome; a comprehensive review of clinical interactions and underlying pathophysiology.
    Clin Endocrinol (Oxf) 2017 Jun 22. Epub 2017 Jun 22.
    Division of Translational and Experimental Medicine, Warwick Medical School, University of Warwick, Coventry, CV4 7AL, United Kingdom.
    Polycystic ovary syndrome (PCOS) is the most prevalent endocrine disorder in women of reproductive age. PCOS is associated with multiple co-morbidities including, obesity, insulin resistance and type 2 diabetes, as well as mood disorders and impaired quality of life (QoL). Obstructive sleep apnoea (OSA) is also a common medical condition that is often undiagnosed, particularly in women. Read More

    Adipose Tissue-Derived Omentin-1 Function and Regulation.
    Compr Physiol 2017 Jun 18;7(3):765-781. Epub 2017 Jun 18.
    Laboratory of Cardiovascular Medicine, Tokyo University of Pharmacy and Life Sciences, Hachioji-City, Tokyo, Japan.
    Omentin-1, also known as intelectin-1, is a recently identified novel adipocytokine of 313 amino acids, which is expressed in visceral (omental and epicardial) fat as well as mesothelial cells, vascular cells, airway goblet cells, small intestine, colon, ovary, and plasma. The level of omentin-1 expression in (pre)adipocytes is decreased by glucose/insulin and stimulated by fibroblast growth factor-21 and dexamethasone. Several lines of experimental evidence have shown that omentin-1 plays crucial roles in the maintenance of body metabolism and insulin sensitivity, and has anti-inflammatory, anti-atherosclerotic, and cardiovascular protective effects via AMP-activated protein kinase/Akt/nuclear factor-κB/mitogen-activated protein kinase (ERK, JNK, and p38) signaling. Read More

    Methylenetetrahydrofolate reductase C677T polymorphism and the risks of polycystic ovary syndrome: an updated meta-analysis of 14 studies.
    Oncotarget 2017 Jun 14. Epub 2017 Jun 14.
    Zhangjiagang, The First Clinical College, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.
    Some studies have reported an association between the Methylenetetrahydrofolate reductase (MTHFR) C667T genetic variant and risk of polycystic ovary syndrome (PCOS), although the results remain controversial. A systematic search was conducted on PubMed, Web of Science, EMBASE, Ovid, Chinese National Knowledge Databases and WanFang databases with relevant keywords. Fourteen studies of sixteen distinct populations involving 1478 PCOS cases and used to conduct a meta-analysis. Read More

    Pelvic floor dysfunction and polycystic ovary syndrome.
    Hum Fertil (Camb) 2017 Feb 21:1-6. Epub 2017 Feb 21.
    d Student Research Committee , Hormozgan University of Medical Sciences , Bandar Abbas , Iran.
    The purpose of this study was to compare the prevalence of pelvic floor dysfunction (PFD) symptoms in patients with and without polycystic ovary syndrome (PCOS) and among different PCOS phenotypes. This was a case-control study. All participants were assessed using ultrasonography to determine the presence or absence of polycystic ovaries (PCO) and allocated to the case or control group (having healthy females whose husbands were diagnosed with male infertility). Read More

    Comparative effectiveness of 9 ovulation-induction therapies in patients with clomiphene citrate-resistant polycystic ovary syndrome: a network meta-analysis.
    Sci Rep 2017 Jun 19;7(1):3812. Epub 2017 Jun 19.
    Department of Reproductive Medical Center, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
    The comparative efficacies of ovulation-induction treatments in patients with clomiphene citrate-resistant (CCR) polycystic ovary syndrome (PCOS) are not well known. Therefore, we conducted a network meta-analysis to rank the reproductive efficacies of these treatments. We ultimately included 26 randomized clinical trials with 2722 participants and 9 types of therapies: clomiphene citrate (CC), metformin, letrozole, follicle stimulating hormone (FSH), human menopausal gonadotropin (hMG), unilateral laparoscopic ovarian drilling (ULOD), bilateral laparoscopic ovarian drilling (BLOD), the combination of metformin with letrozole (metformin+letrozole), and the combination of metformin with CC (metformin+CC). Read More

    Daily consumption of commercial chicken feed and meat lead to alterations in serum cholesterol and steroidal sex hormones in female rats.
    Pak J Pharm Sci 2017 Jan;30(1 Suppl):257-261
    Department of Geriatrics, Monash University, Melbourne, Australia.
    Poultry consumption is increased worldwide owing to better taste, easy availability and low cost. The present study was designed to investigate the effects of the chicken feed, conventional chicken meat and organic chicken meat on the % growth rate, serum cholesterol, progesterone, testosterone and estrogen levels in female rats. Hundred female Albino Wistar rats were randomly assigned to four groups (n=25). Read More

    New biomarkers for diagnosis and management of polycystic ovary syndrome.
    Clin Chim Acta 2017 Jun 15;471:248-253. Epub 2017 Jun 15.
    Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, The University of California at Davis, Davis, CA, United States; Department of Veterans Affairs Northern California Health Care System, Mather, CA, United States. Electronic address:
    Polycystic ovary syndrome (PCOS) is the most common endocrine disorder affecting young women. Even though the definition of PCOS has changed over the years, all diagnostic criteria include two or more of the following: oligomenorrhea/oligoovulation/anovulation, androgen excess and polycystic ovaries (PCO). Traditional method of assessing the ovarian morphology has been transvaginal pelvic ultrasound. Read More

    Phoenixin-14 concentrations are increased in association with luteinizing hormone and nesfatin-1 concentrations in women with polycystic ovary syndrome.
    Clin Chim Acta 2017 Jun 15;471:243-247. Epub 2017 Jun 15.
    The Key Laboratory of Reproductive Genetics, Ministry of Education (Zhejiang University), Hangzhou, China; Department of Pathology and Pathophysiology, School of Medicine, Zhejiang University, Hangzhou, China. Electronic address:
    Background: Polycystic ovary syndrome (PCOS) is commonly characterized by obesity, insulin resistance (IR), hyperandrogenemia and hirsutism. Following the reported relationship between phoenixin-14 and gonadotropin production in rat hypothalamic-pituitary-gonadal axis, the present study was designed to investigate the circulating concentrations of phoenixin-14 and their associations with the concentrations of sex hormones including luteinizing hormone (LH), follicular stimulating hormone (FSH), estradiol (E2), progesterone (P4) and total testosterone (TT) in PCOS patients.

    Methods: A total of 41 women with diagnosed PCOS using Rotterdam criteria and 37 healthy individuals were enrolled in the study. Read More

    Effect of obesity and its related metabolic factors on serum anti-Müllerian hormone concentrations in women with and without polycystic ovaries.
    Reprod Biomed Online 2017 Jun 3. Epub 2017 Jun 3.
    CHU Lille, Service de gynécologie endocrinienne et médecine de la reproduction, Hôpital Jeanne de Flandre, Lille, France.
    The relationship between serum anti-Müllerian hormone (AMH) levels, body mass index (BMI) and related metabolic factors were investigated in women with polycystic ovary syndrome (PCOS). A total of 691 women aged between 18 and 35 years, referred to the Department of Gynaecological Endocrinology at the University Hospital of Lille between 2009 and 2014 were included: 137 controls and 554 women with PCOS. Mean serum AMH levels were slightly but significantly lower in women with PCOS who were overweight or obese (BMI ≥25) compared with women of normal weight (BMI <25) (P < 0. Read More

    Ovarian morphology is associated with insulin resistance in women with polycystic ovary syndrome: a cross sectional study.
    Fertil Res Pract 2017 30;3. Epub 2017 May 30.
    Center for Reproductive Health, University of California at San Francisco, 2356 Sutter Street, San Francisco, 94115 CA USA.
    Background: Polycystic ovary syndrome (PCOS) is a very common disorder well known to be associated with insulin resistance and metabolic disease. Insulin resistance is likely involved in the promotion of the PCOS reproductive phenotype and may mediate some of the ovarian morphology seen in the disorder. The phenotype of each individual woman with PCOS can vary widely as can her metabolic risk. Read More

    Polycystic ovary syndrome and risk of endometrial, ovarian, and breast cancer: a systematic review.
    Fertil Res Pract 2016 5;2:14. Epub 2016 Dec 5.
    Department of Obstetrics and Gynecology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA USA.
    Background: Polycystic ovary syndrome (PCOS) is a complex endocrine disorder with an estimated prevalence of 4-21% in reproductive aged women. The altered metabolic and hormonal environment among women with PCOS may increase their risk of some types of cancer.

    Methods: We performed a comprehensive review of the literature using numerous search terms for all studies examining the associations between polycystic ovary syndrome and related characteristics and cancer published in English through October 2016. Read More

    The Distribution of Stroma and Antral Follicles Differs between Insulin-Resistance and Hyperandrogenism-Related Polycystic Ovarian Syndrome.
    Front Endocrinol (Lausanne) 2017 31;8:117. Epub 2017 May 31.
    Department of Obstetrics and Gynecology, Policlinico Universitario Duilio Casula, University of Cagliari, Cagliari, Italy.
    Introduction: Although insulin resistance plays an important pathogenetic role in polycystic ovary syndrome (PCOS), no correlation between ultrasound PCOS pattern and insulin resistance has yet been reported. The aim of this retrospective observational study was to assess whether the ovarian ultrasonographic parameter differed between PCOS women with insulin resistance and those with a hyperandrogenic profile.

    Materials And Methods: Women who fulfilled the Rotterdam criteria for PCOS were retrospectively studied. Read More

    Efficacy of Follicle-Stimulating Hormone (FSH) Alone, FSH + Luteinizing Hormone, Human Menopausal Gonadotropin or FSH + Human Chorionic Gonadotropin on Assisted Reproductive Technology Outcomes in the "Personalized" Medicine Era: A Meta-analysis.
    Front Endocrinol (Lausanne) 2017 1;8:114. Epub 2017 Jun 1.
    Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
    Setting: Luteinizing hormone (LH) and human chorionic gonadotropin (hCG) act on the same receptor, activating different signal transduction pathways. The role of LH or hCG addition to follicle-stimulating hormone (FSH) as well as menopausal gonadotropins (human menopausal gonadotropin; hMG) in controlled ovarian stimulation (COS) is debated.

    Objective: To compare FSH + LH, or FSH + hCG or hMG vs. Read More

    Salivary testosterone measurement in women with and without polycystic ovary syndrome.
    Sci Rep 2017 Jun 15;7(1):3589. Epub 2017 Jun 15.
    Research Faculty, Weill Cornell Medicine, PO Box, 24144, Doha, Qatar.
    Clinical and/or biochemical hyperandrogenism is one of the diagnostic criteria for PCOS. An evaluation of the role of salivary testosterone (salT) and androstenedione (salA) for the diagnosis of PCOS was undertaken in a cross sectional study involving 65 women without PCOS and 110 women with PCOS fulfilling all 3 diagnostic Rotterdam criteria. Serum and salivary androgen measurements were determined by LC-MS/MS. Read More


    The promising effect of linagliptin and/or indole-3-carbinol on experimentally-induced polycystic ovarian syndrome.
    Chem Biol Interact 2017 Jun 13;273:190-199. Epub 2017 Jun 13.
    Pharmacology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
    Polycystic ovarian syndrome (PCOS) is one of the most common medical conditions that lead to female infertility worldwide. The aim of this study was to assess the effect of linagliptin and/or indole-3-carbinol (I3C) on PCOS in female rats. Fifty female Wistar rats were randomly allocated into five equal groups: Control group; Letrozole-induced PCOS group; Letrozole + Linagliptin group; Letrozole + I3C group and Letrozole + Linagliptin + I3C group. Read More

    Nuclear factor-κB expression in the endometrium of normal and overweight women with polycystic ovary syndrome.
    J Obstet Gynaecol 2017 Jun 15:1-7. Epub 2017 Jun 15.
    e Department of Medical Biochemistry, School of Medicine , Firat University , Elazig , Turkey.
    The aim of this study was to investigate whether the expression levels of endometrial NFκB p65 differ between normal weight and overweight PCOS women and to compare them with BMI-matched control subjects without PCOS. The study group comprised 20 normal weight (BMI: 18.5-24. Read More

    Omega-3 supplementation effects on polycystic ovary syndrome symptoms and metabolic syndrome.
    J Res Med Sci 2017 30;22:64. Epub 2017 May 30.
    Department of Obstetrics and Gynecology, Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
    Background: Polycystic ovary syndrome (PCOS) is the most common female endocrine disorder with unknown etiology and with different complications. The aim of this study was to evaluate the effect of omega-3 supplementation on PCOS symptoms and metabolic syndrome.

    Materials And Methods: This double-blind clinical trial was performed in 2015 in Alzahra and Shahid Beheshti Hospitals, Isfahan, Iran, on 88 patients with PCOS. Read More

    BIOCHEMICAL CONTROL DURING LONG TERM FOLLOW-UP OF 230 ADULT PATIENTS WITH CUSHING'S DISEASE: A MULTI-CENTER RETROSPECTIVE STUDY.
    Endocr Pract 2017 Jun 14. Epub 2017 Jun 14.
    Massachusetts General Hospital, Boston, MA.
    Objectives: Cushing's disease (CD) results from excessive exposure to glucocorticoids caused by an adrenocorticotropic hormone-secreting pituitary tumor. Inadequately-treated CD is associated with significant morbidity and elevated mortality. Multi-center data on CD patients treated in routine clinical practice are needed to assess treatment outcomes in this rare disorder. Read More

    Non-alcoholic fatty liver disease in women with polycystic ovary syndrome: systematic review and meta-analysis.
    J Endocrinol Invest 2017 Jun 13. Epub 2017 Jun 13.
    Department of Obstetrics and Gynecology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
    Purpose: Non-alcoholic fatty liver disease (NAFLD) is an insidious pathologic condition that can manifest from simple steatosis to steatohepatitis (NASH) with potential progression to cirrhosis. Like the polycystic ovary syndrome (PCOS), NAFLD is associated with obesity, diabetes mellitus, insulin resistance and metabolic syndrome. PCOS women have an increased risk of NAFLD, but it is debatable which features of PCOS, either specific (androgen excess) or unspecific (metabolic derangements) affect the NAFLD risk. Read More

    Uncommon Presentation of Idiopathic Intracranial Hypertension in a Patient with Polycystic Ovary Syndrome: A Case Report.
    Case Rep Neurol 2017 Jan-Apr;9(1):49-53. Epub 2017 Mar 21.
    bKing Abdulaziz Medical City/King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
    Introduction: Idiopathic intracranial hypertension is a rare condition characterized by increased intracranial pressure without clinical, laboratory, or radiological evidence of intracranial pathology. Early management could prevent irreversible outcomes.

    Case Presentation: A 17-year-old single Arabian female of Arab origin presented with a 2-day complaint of horizontal diplopia and transient visual obscurations. Read More

    Competing Factors Link to Bone Health in Polycystic Ovary Syndrome: Chronic Low-Grade Inflammation Takes a Toll.
    Sci Rep 2017 Jun 13;7(1):3432. Epub 2017 Jun 13.
    Centre for Menstrual Cycle and Ovulation Research, Division of Endocrinology, Department of Medicine, University of British Columbia; Vancouver Coastal Health Research Institute, Vancouver, Canada.
    Chronic inflammation predisposes to poor bone health. Women with polycystic ovary syndrome (PCOS) experience androgen excess, ovulatory disturbances, insulin resistance, abdominal adiposity and chronic inflammation. Our objective was to investigate the relationships among bone health parameters, chronic subclinical inflammation and anthropometric measures in premenopausal women with and without PCOS. Read More

    The Investigation of Polymorphisms in DNA Repair Genes (XRCC1, APE1 and XPD) in Women with Polycystic Ovary Syndrome
    Asian Pac J Cancer Prev 2017 05 1;18(5):1219-1223. Epub 2017 May 1.
    Department of Medical Biology and Genetics, Faculty of Medicine, Inonu University, Private Clinic, Turkey. Email:
    Background: PCOS was reported to arise from the interaction of genetic and environmental factors. Some studies reported that women with PCOS have DNA damage and chromosome breakage. Such studies bring to mind the genes that are involved in DNA repairing. Read More

    Hochu-ekki-to Treatment Improves Reproductive and Immune Modulation in the Stress-Induced Rat Model of Polycystic Ovarian Syndrome.
    Molecules 2017 Jun 13;22(6). Epub 2017 Jun 13.
    Department of Biochemistry, Chungnam National University School of Medicine, Daejeon 301747, Korea.
    The traditional herbal medicine, Hochu-ekki-to, has been shown to have preventive effects on viral infection and stress. This study aimed to evaluate the clinical effects of Hochu-ekki-to on two stress-related rat models of polycystic ovarian syndrome. Female Sprague-Dawley rats were divided into control and treatment groups, the latter of which were subjected to stress induced by exposure to adrenocorticotropic hormone (ACTH) or cold temperatures. Read More

    Effect of bisphenol A on reproductive processes: A review of in vitro, in vivo and epidemiological studies.
    J Appl Toxicol 2017 Jun 13. Epub 2017 Jun 13.
    Department of Animal Reproduction Biotechnology and Environmental Hygiene, West Pomeranian University of Technology in Szczecin, Janickiego 29, 71-270, Szczecin, Poland.
    As bisphenol A (BPA) is characterized by a pronounced influence on human hormonal regulation, particular attention has been aimed at understanding its role in reproductive processes in males and females, as well as on fetal development. Owing to the increasing number of alarming reports on the negative consequences of the presence of BPA in human surroundings, more and more studies are being undertaken to clarify the negative effects of BPA on human reproductive processes. The aim of this work was to collect and summarize data on the influence of BPA exposure on reproductive health. Read More

    Metabolic and androgen profile in underweight women with polycystic ovary syndrome.
    Arch Gynecol Obstet 2017 Jun 12. Epub 2017 Jun 12.
    Department of Endocrinology and Metabolism and Division of Laboratory Research, University Hospital Essen, University of Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Germany.
    Introduction: Polycystic ovary syndrome (PCOS) is a disorder associated with insulin resistance and obesity. Aim of our study is to clarify the prevalence of underweight in PCOS patients and whether metabolic and androgen profiles of PCOS differ depending on normal or low body weight.

    Methods: Out of 1269 consecutive patients with PCOS recruited from the Department of Endocrinology and Metabolism at the University of Duisburg-Essen, 19 patients (1. Read More

    Zinc finger gene 217 (ZNF217) Promoted Ovarian Hyperstimulation Syndrome (OHSS) through Regulating E2 Synthesis and Inhibiting Thrombospondin-1 (TSP-1).
    Sci Rep 2017 Jun 12;7(1):3245. Epub 2017 Jun 12.
    Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200135, China.
    Zinc finger gene 217 (ZNF217) is a candidate gene of polycystic ovary syndrome (PCOS) which is vulnerable to ovarian hyperstimulation syndrome (OHSS). However, the relationship between ZNF217 and OHSS is largely unknown. Our study demonstrated that ZNF217 was mainly distributed in the granulosa cells of rat ovary. Read More

    Which origin for polycystic ovaries syndrome: Genetic, environmental or both?
    Ann Endocrinol (Paris) 2017 Jun 9. Epub 2017 Jun 9.
    Department of Endocrinology, Diabetology and Reproduction, groupe hospitalier l'Archet, CHU de Nice, 151, route de Saint-Antoine-de-Ginestière, 06202 Nice, France; Inserm U1065/C3M, hôpital de l'Archet, 151, route de Saint-Antoine-de-Ginestière, 06202 Nice, France.
    Polycystic ovaries syndrome (PCOS), the most common female endocrine disorder, affects 7-10% of women of childbearing age. It includes ovarian hyperandrogenism, impaired follicular maturation, anovulation and subfertility. Insulin resistance, although present in most cases, is not necessary for diagnosis. Read More

    [Physical exercise is a help for lean women with polycystic ovary syndrome].
    Ugeskr Laeger 2017 Jun;179(23)
    Polycystic ovary syndrome (PCOS) affects 12-21% of women in the childbearing age and is the most common cause of hyperandrogenaemia and anovulatory infertility. There is an increase in insulin resistance in both overweight and lean women with PCOS. Exercise treatment is mandatory among the overweight women due to sufficient evidence that it can improve the signs and symptoms of PCOS. Read More

    Genetics of polycystic ovary syndrome.
    Expert Rev Mol Diagn 2017 Jul 19;17(7):723-733. Epub 2017 Jun 19.
    d Chief Officer of Academic Health and Hospital Affairs, State University Plaza , The State University of New York , Albany , NY , USA.
    Introduction: Polycystic ovary syndrome (PCOS) is a hormonal and metabolic disorder affecting 5 to 20% of reproductive-aged women worldwide that results in androgen excess, menstrual dysfunction and oligo-ovulatory subfertility, with increased risks for type 2 diabetes, endometrial adenocarcinoma, and potentially vascular disease, among other morbidities. PCOS is a complex genetic trait with strong heritability accounting for as high as 70% of the development of the disorder. Areas covered: The authors summarize the historical and recent findings of genetic studies of PCOS, such as familial studies, twin studies, and molecular genetic studies, including the results of recent genome wide associated studies. Read More

    Risk of developing obstructive sleep apnea among women with polycystic ovarian syndrome: a nationwide longitudinal follow-up study.
    Sleep Med 2017 Mar 10. Epub 2017 Mar 10.
    Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Psychiatry, College of Medicine, National Yang-Ming University, Taipei, Taiwan. Electronic address:
    Background: Previous cross-sectional studies have suggested a comorbid relationship between polycystic ovarian syndrome (PCOS) and obstructive sleep apnea (OSA). However, the temporal association between these two distinct diseases has not yet been investigated.

    Methods: Using the Taiwan National Health Insurance Research Database, 4595 women with PCOS and 4595 (1:1) age-/sex-matched controls were enrolled into the present study between 1998 and 2009, and followed to the end of 2011. Read More

    Gingival Inflammation and Salivary or Serum Granulocyte Secreted Enzymes in Patients With Polycystic Ovary Syndrome.
    J Periodontol 2017 Jun 9:1-10. Epub 2017 Jun 9.
    Department of Dental Medicine, Karolinska Institute, Huddinge, Sweden.
    Background: The objective of this cross-sectional study was to investigate the levels of salivary and serum matrix metalloproteinase-9 (MMP-9), myeloperoxidase (MPO), neutrophil elastase (NE) and MMP-9/tissue inhibitors of metalloproteinase (TIMP-1) ratio in polycystic ovary syndrome (PCOS) patients and systemically healthy controls, in the presence or absence of gingivitis.

    Methods: Serum and salivary levels of these biomarkers were evaluated in periodontally healthy women with PCOS (Ph) (n=45); women with PCOS and gingivitis (Pg) (n=35); systemically and periodontally healthy women (Hh) (n=25); systemically healthy women with gingivitis (Hg) (n=20). IFMA or ELISA was used to determine the levels of these biomarkers. Read More

    Effect of Non-surgical Periodontal Therapy Along With Myo-Inositol on High Sensitivity C-Reactive Protein and Insulin Resistance in Polycystic Ovary Syndrome Women Having Chronic Periodontitis: A Randomized Controlled Trial.
    J Periodontol 2017 Jun 9:1-13. Epub 2017 Jun 9.
    Department of Periodontics and Oral Implantology, Post Graduate Institute of Dental Sciences, Rohtak, Haryana, India.
    Background: The purpose of this study was to evaluate the effect of non-surgical periodontal therapy along with medical treatment on the level of serological marker of inflammation {high sensitivity-C Reactive Protein (hsCRP)} and Insulin resistance{Homeostatic Model Assessment(HOMA)} in Polycystic ovarian syndrome (PCOS) women having periodontitis.

    Methods: Women having PCOS with chronic periodontitis (n=60) were randomly divided into two groups. Test Group: treated with scaling and root planing along with Myo-inositol and Control Group: treated with Myo-inositol along with oral hygiene instructions. Read More

    [Optimal Ovulation Induction in Polycystic Ovary Syndrome Resistant to Clomiphene Citrate or Letrozole.]
    Sichuan Da Xue Xue Bao Yi Xue Ban 2016 Nov;47(6):874-877
    Department of Obstetrics and Gynecology,West China Second University Hospital,Sichuan University,Key Laboratory of Birth Defects and Related Disease of Women and Children (Sichuan University),Ministry of Education,Chengdu 610041,China.
    Objectives: To investigate the optimal ovulation induction with the combination of combining letrozole(LE),clomiphene citrate (CC),and human menopausal gonadotropin (HMG) in polycystic ovary syndrome(PCOS) patients resistant to CC or LE.

    Methods: Two hundreds nine PCOS patients (209 cycles) resistant to CC or LE were randomly divided into three groups: CC+HMG group (59 cycles),LE+HMG group (72 cycles) and LE+CC group (78 cycles).The patients in LE+CC group unable to form the dominant follicle after 54 cycles were enrolled into LE+CC+HMG group. Read More

    Elevated anti-Mullerian hormone in lean women may not indicate polycystic ovarian syndrome.
    Aust N Z J Obstet Gynaecol 2017 Jun 9. Epub 2017 Jun 9.
    Westmead Fertility Centre, Sydney, New South Wales, Australia.
    Background: Polycystic ovarian syndrome (PCOS) is a heterogeneous disorder with clinical features shared with functional hypogonadotrophic hypogonadism (FHH).

    Aim: To investigate the usefulness of an elevated (>40 pmol/L) anti-Mullerian hormone (AMH) in identifying PCOS and distinguishing PCOS from FHH.

    Materials And Methods: 141 patients with an elevated AMH and body mass index either <20 kg/m(2) (lean) or >30 kg/m(2) (obese) were selected and three subgroups analysed - obese, lean, lean with suspected FHH. Read More

    A methodology for elucidating regulatory mechanisms leading to changes in lipid profiles.
    Metabolomics 2017 29;13(7):81. Epub 2017 May 29.
    School of Biosciences, University of Nottingham, Sutton Bonington, LE12 5RD UK.
    Introduction: It is difficult to elucidate the metabolic and regulatory factors causing lipidome perturbations.

    Objectives: This work simplifies this process.

    Methods: A method has been developed to query an online holistic lipid metabolic network (of 7923 metabolites) to extract the pathways that connect the input list of lipids. Read More

    Chromium supplementation and polycystic ovary syndrome: A systematic review and meta-analysis.
    J Trace Elem Med Biol 2017 Jul 21;42:92-96. Epub 2017 Apr 21.
    Food Security Research Center, Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address:
    Introduction: polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women. Some vitamins and mineral can play role in improvement of PCOS. Chromium (Cr) is an essential element in glucose and insulin homeostasis. Read More

    Testosterone improves the differentiation efficiency of insulin-producing cells from human induced pluripotent stem cells.
    PLoS One 2017 8;12(6):e0179353. Epub 2017 Jun 8.
    Institute of Public Health, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
    Human induced pluripotent stem cells (hiPSCs) may provide potential resource for regenerative medicine research, including generation of insulin-producing cells for diabetes research and insulin production. Testosterone (T) is an androgen hormone which promotes protein synthesis and improves the management of type 2 diabetes in clinical studies. Concurrently, co-existed hyperandrogenism and hyperinsulinism is frequently observed in polycystic ovary syndrome, congenital adrenal hyperplasia and some of Wermer's syndrome. Read More

    Hyperandrogenism in adolescent girls: relationship with the somatotrophic axis.
    J Pediatr Endocrinol Metab 2017 May;30(5):561-568
    Institute of Maternal and Child Research, Faculty of Medicine, University of Chile, Santiago.
    Background: During puberty there is a physiologic increase in adrenal and ovarian androgens. It has been suggested that the somatotrophic axis may be related to the development of hyperandrogenism and anovulation in non-obese adult women with polycystic ovarian syndrome (PCOS). The objective of the study was to investigate whether ovarian androgen secretion in young postmenarchal girls is related to the function of their somatotropic axis. Read More

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