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    [Frequency of increased thyrotropin in women with hyperprolactinemia].
    Rev Med Inst Mex Seguro Soc 2017 ;55 Suppl 1:S53-S57
    División de Investigación en Salud, Hospital de Ginecoobstetricia 4 "Luis Castelazo Ayala", Instituto Mexicano del Seguro Social, Ciudad de México, México.
    Background: Hypothyroidism has been associated to hyperprolactinemia. The aim was to establish the frequency of high thyrotropin (TSH) levels in women with hyperprolactinemia.

    Methods: Retrospective, observational, open, and non-controlled study, which included all the non-pregnant women whose prolactin (PRL) and TSH levels were measured between January 1 and December 31, 2014. Read More

    Comparing the Effects of Agnugol and Metformin on Oligomenorrhea in Patients with Polycystic Ovary Syndrome: A Randomized Clinical Trial.
    J Clin Diagn Res 2016 Dec 1;10(12):QC13-QC16. Epub 2016 Dec 1.
    Instructor, Faculty of Nursing, School of Nursing and Midwifery, Hamadan University of Medical Sciences , Hamadan, Iran .
    Introduction: Polycystic Ovarian Syndrome (PCOS) is the most common endocrinopathy and cause of oligomenorrhea in women.

    Aim: The present study was conducted with the aim to compare the effect of Agnugol and Metformin drugs on oligomenorrhea in patients with PCOS.

    Materials And Methods: This study was a clinical trial on 120 women with PCOS and had oligomenorrhea, referring to a gynaecology clinic Fatemieh, Hamadan city, Iran, 2015. Read More

    Anti-Mullerian Hormone: A Marker of Ovarian Reserve and its Association with Polycystic Ovarian Syndrome.
    J Clin Diagn Res 2016 Dec 1;10(12):QC10-QC12. Epub 2016 Dec 1.
    Associate Professor, Department of Pathology, King George's Medical University , Lucknow, Uttar Pradesh, India .
    Introduction: Anti-Mullerian Hormone (AMH) is a useful endocrine marker for assessing the ovarian reserve. AMH serum level reflects the number of follicles that have made the transition from the primordial pool into the growing follicle pool, and it is not controlled by gonadotropins.

    Aim: The present study was conducted to correlate serum AMH levels with Polycystic Ovarian Syndrome (PCOS) and type of treatment protocol. Read More

    Adiposity Indexes as Phenotype-Specific Markers of Preclinical Metabolic Alterations and Cardiovascular Risk in Polycystic Ovary Syndrome: A Cross-Sectional Study.
    Exp Clin Endocrinol Diabetes 2017 Feb 15. Epub 2017 Feb 15.
    Gynecological Endocrinology Unit, Division of Endocrinology, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil, 90035-003.
    Polycystic ovary syndrome (PCOS) is a common condition in women of reproductive age. 2 PCOS phenotypes (classic and ovulatory) are currently recognized as the most prevalent, with important differences in terms of cardiometabolic features. We studied the performance of different adiposity indexes to predict preclinical metabolic alterations and cardiovascular risk in 234 women with PCOS (173 with classic and 61 with ovulatory PCOS) and 129 controls. Read More

    Impact of Hormonal Contraception and Weight Loss on HDL-C efflux and Lipoprotein Particles in Women with Polycystic Ovary Syndrome.
    Clin Endocrinol (Oxf) 2017 Feb 15. Epub 2017 Feb 15.
    Departments of Obstetrics and Gynecology, Penn State College of Medicine, Hershey, PA.
    Objective: To study the effects of oral contraceptive pills (OCP), the first line treatment for PCOS, on HDL-C function (reverse cholesterol efflux capacity) and lipoprotein particles measured by NMR spectroscopy.

    Design: Secondary analysis of a randomized controlled trial (OWL-PCOS) of OCP or Lifestyle (intensive lifestyle modification) or Combined (OCP+Lifestyle) treatment for 16 weeks.

    Patients: 87 overweight/obese women with PCOS at two academic centers. Read More

    ERBB4 Confers Risk for Polycystic Ovary Syndrome in Han Chinese.
    Sci Rep 2017 Feb 14;7:42000. Epub 2017 Feb 14.
    Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.
    A recent genome-wide association study (GWAS) of polycystic ovary syndrome (PCOS) in European cohorts has identified six susceptibility loci mapping to 11q22.1 (YAP1), 2p21 (THADA), 11p14.1 (FSHB), 2q34 (ERBB4), 12q21. Read More

    Circulatory microRNA 23a and microRNA 23b and polycystic ovary syndrome (PCOS): the effects of body mass index and sex hormones in an Eastern Han Chinese population.
    J Ovarian Res 2017 Feb 13;10(1):10. Epub 2017 Feb 13.
    Department of Integrative Medicine and Neurobiology, State Key Lab of Medical Neurobiology, School of Basic Medical Sciences, Shanghai Medical College; Institute of Acupuncture Research (WHO collaborating center for traditional medicine) and Institute of Brain Science, Brain Science Collaborative Innovation Center, Fudan University, Shanghai, 200032, China.
    Background: MicroRNAs (miRNAs) regulate the expression of genes involved in various cellular functions related to metabolism, inflammation, and reproduction. This study evaluated the effects of sex hormones and obesity on the expression of circulating miR-23a and miR-23b in women with polycystic ovary syndrome (PCOS) and healthy women.

    Methods: Serum sex hormones concentrations and body mass index (BMI) were measured in 18 women with PCOS and in 30 healthy women from the East China area and these measurements were correlated with serum miR-23a/b levels. Read More

    C-Peptide, Baseline and Postprandial Insulin Resistance after a Carbohydrate-Rich Test Meal - Evidence for an Increased Insulin Clearance in PCOS Patients?
    Geburtshilfe Frauenheilkd 2017 Jan;77(1):59-65
    Frauenklinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, München, Germany.
    Introduction Known characteristics of patients with PCOS include infertility, menstrual disorders, hirsutism and also often insulin resistance. These symptoms increase with increasing body weight. In the LIPCOS study (Lifestyle Intervention for Patients with Polycystic Ovary Syndrome [PCOS]) long-term changes of the PCOS in dependence on pregnancy and parenthood were systematically assessed. Read More

    The effect of estradiol on granulosa cell responses to FSH in women with polycystic ovary syndrome.
    Reprod Biol Endocrinol 2017 Feb 10;15(1):13. Epub 2017 Feb 10.
    Reproductive Medicine, University of California, 200 West Arbor Drive MC: 8710, San Diego, CA, 92103, USA.
    Background: The influence of estradiol (E2) on granulosa cell (GC) function has not been tested clinically in women with polycystic ovary syndrome (PCOS). The objective of this study is to determine if E2 influences GC responses to FSH in women with PCOS.

    Methods: This is a two phase, single cohort study conducted over a 2-year period at a single academic center. Read More

    Overexpression of salusin-β is associated with poor prognosis in ovarian cancer.
    Oncol Rep 2017 Mar 7;37(3):1826-1832. Epub 2017 Feb 7.
    Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China.
    Ovarian cancer is recognized as one of the worst gynecologic malignancies associated with rapid metastasis and poor overall survival rate. The identified valuable molecular biomarkers criticize importance of timely diagnosis for ovarian cancer. Salusin-β levels are dramatically increased in women with polycystic ovarian syndrome. Read More

    Animal models of hyperandrogenism and ovarian morphology changes as features of polycystic ovary syndrome: a systematic review.
    Reprod Biol Endocrinol 2017 Feb 10;15(1):12. Epub 2017 Feb 10.
    Gynecological Endocrinology Unit, Division of Endocrinology, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos, 2350, 90035 003, Porto Alegre, RS, Brazil.
    Polycystic ovary syndrome (PCOS) is a common endocrine disorder, affecting 9-18% of women in reproductive age that causes hyperandrogenism and infertility due to dysfunctional follicular maturation and anovulation. The etiology of PCOS is still poorly known, and information from experimental animal models may help improve current understanding of the mechanisms of PCOS initiation and development. Therefore, we conducted a systematic review of currently available methods for simulation of PCOS in experimental models, focusing on two main endocrine traits: ovarian morphology changes and circulating levels of sex hormones and gonadotropins. Read More

    Upregulation of FoxO 1 Signaling Mediates the Proinflammatory Cytokine Upregulation in the Macrophage from Polycystic Ovary Syndrome Patients.
    Clin Lab 2017 Feb;63(2):301-311
    Background: Chronic activation of macrophage-mediated inflammatory signals in insulin-sensitive metabolic tissues is thought to be one of the causes of insulin resistance-one of the hallmarks of the metabolic syndrome. Insulin resistance is a feature of polycystic ovary syndrome (PCOS) and is related to mitochondrial and endothelial function.

    Methods: In the present study, we investigated the phosphorylation level of FoxO 1, which is suppressed by the action of AKT, triggers the TLR4 inflammatory signaling pathway in the macrophages, from polycystic ovary syndrome patients or normal subjects. Read More

    Anterior Segment Findings in Women with Polycystic Ovary Syndrome.
    Turk J Ophthalmol 2017 Jan 17;47(1):24-27. Epub 2017 Jan 17.
    Tepecik Training and Research Hospital, Ophthalmology Clinic, İzmir, Turkey.
    Objectives: This study aimed to investigate the anterior segment in women with polycystic ovary syndrome (PCOS) and to compare them with those of healthy reproductive-age female volunteers.

    Materials And Methods: The study included 50 right eyes of 50 women with PCOS (group 1) and 50 right eyes of 50 healthy women (group 2). Intraocular pressure, Schirmer's test, tear film break-up time and central corneal thickness were evaluated in all subjects. Read More

    Sex differences in the effects of androgens acting in the central nervous system on metabolism.
    Dialogues Clin Neurosci 2016 Dec;18(4):415-424
    Department of Medicine, Section of Endocrinology and Metabolism, Tulane University Health Sciences Center, School of Medicine, New Orleans, Louisiana, USA.
    One of the most sexually dimorphic aspects of metabolic regulation is the bidirectional modulation of glucose and energy homeostasis by testosterone in males and females. Testosterone deficiency predisposes men to metabolic dysfunction, with excess adiposity, insulin resistance, and type 2 diabetes, whereas androgen excess predisposes women to insulin resistance, adiposity, and type 2 diabetes. This review discusses how testosterone acts in the central nervous system, and especially the hypothalamus, to promote metabolic homeostasis or dysfunction in a sexually dimorphic manner. Read More

    Is acne a sign of androgen excess disorder or not?
    Eur J Obstet Gynecol Reprod Biol 2017 Jan 23;211:21-25. Epub 2017 Jan 23.
    Department of Endocrinology, Erciyes University Medical School, Kayseri, Turkey.
    Objective: Acne is not solely a cosmetic problem. The clinical importance of acne in the estimation of androgen excess disorders is controversial. Recently, the Amsterdam ESHRE/ASRM-sponsored third PCOS Consensus Workshop Group suggested that acne is not commonly associated with hyperandrogenemia and therefore should not be regarded as evidence of hyperandrogenemia. Read More

    Acute exercise elicits differential expression of insulin resistance genes in the skeletal muscle of patients with polycystic ovary syndrome.
    Clin Endocrinol (Oxf) 2017 Feb 8. Epub 2017 Feb 8.
    School of Physical Education and Sport, University of Sao Paulo, Sao Paulo, Brazil.
    Objective: This study aimed to explore the role of acute exercise on skeletal muscle gene expression related to insulin resistance in patients with polycystic ovary syndrome (PCOS) and controls.

    Methods: Four obese women with PCOS and 4 body controls subjects (CTRL) participated in this study. After an overnight fast, the subjects underwent a single 40-minute bout of aerobic exercise. Read More

    Sterol regulatory element binding protein-1 (SREBP1) gene expression is similarly increased in polycystic ovary syndrome and endometrial cancer.
    Acta Obstet Gynecol Scand 2017 Feb 7. Epub 2017 Feb 7.
    Division of Obstetrics and Gynaecology and Child Health, School of Medicine, Faculty of Medicine and Health Sciences, Queen's Medical Centre, Nottingham University Hospital, Nottingham, UK.
    Introduction: Women with polycystic ovary syndrome (PCOS) have a 3-fold higher risk of endometrial cancer (EC). Insulin resistance and hyperlipidaemia may be pertinent factors in the pathogenesis of both conditions. The aim of this study was to investigate endometrial Sterol Regulatory Element Binding Protein-1 gene (SREBP1) expression in PCOS and EC endometrium, and to correlate endometrial SREBP1 expression with serum lipid profiles. Read More

    Effects of a hyperandrogenaemic state on the proliferation and decidualization potential in human endometrial stromal cells.
    Arch Gynecol Obstet 2017 Feb 6. Epub 2017 Feb 6.
    Department of Gynaecological Endocrinology and Fertility Disorders, University Hospital Heidelberg, Heidelberg, Germany.
    Objective: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women, involving hyperandrogenaemia and insulin resistance. Treatment options include dexamethasone, as well as the off-label use of metformin. To evaluate the impact of those drugs on cyclic changes in endometrial development, we tested possible effects of metformin and dexamethasone on endometrial stromal cells decidualisation, proliferation, and gene regulation in a hyperandrogenaemic microenvironment in vitro. Read More

    Thyroid disorders in polycystic ovary syndrome.
    Eur Rev Med Pharmacol Sci 2017 Jan;21(2):346-360
    Department of Gynaecological Endocrinology, Medical Faculty in Katowice, Medical University of Silesia, Katowice, Poland.
    Objective: Thyroid disorders, especially Hashimoto's thyroiditis (HT), are observed significantly more often in patients with polycystic ovary syndrome (PCOS) than in the general population - approximately 27% and 8%, respectively. This is extremely important in young women, because both disorders are connected with fertility problems. As HT and PCOS occur together, fertility problems may become a serious clinical issue in these patients. Read More

    The impact of obesity on hyperandrogenemia in Korean girls.
    Ann Pediatr Endocrinol Metab 2016 Dec 31;21(4):219-225. Epub 2016 Dec 31.
    Department of Pediatrics, Kangdong Sacred Heart Hospital, Seoul, Korea.
    Purpose: As metabolic complication and polycystic ovarian syndrome due to childhood obesity is rising, the role of hyperandrogenemia (HA) and hyperinsulinism is receiving attention. The aims of this study were to investigate the presence of obvious HA according to pubertal status and to find potential etiologic determinants of HA in Korean obese (OB) girls.

    Methods: We analyzed 91 girls aged 6-17 years (prepuberty, n=54; puberty, n=37). Read More

    Near Infrared Pulsed Light for Permanent Hair Reduction in Fitzpatrick Skin Types IV and V.
    J Cutan Aesthet Surg 2016 Oct-Dec;9(4):249-253
    Department of Dermatology, Kasturba Medical College, Manipal University, Mangalore, Karnataka, India.
    Background: Excessive hair on the face is a significant cause for distress amongst women. Permanent hair reduction methods including lasers and pulsed light devices are increasingly being used.

    Aims: The aim of this study is to evaluate the efficacy and safety of near infrared pulsed light source for permanent hair reduction in women seeking treatment for excessive hair growth on the upper lip and chin. Read More

    Serum Zinc and Adiponectin Levels in Patients with Polycystic Ovary Syndrome, Adjusted for Anthropometric, Biochemical, Dietary Intake, and Physical Activity Measures.
    Biol Trace Elem Res 2017 Feb 3. Epub 2017 Feb 3.
    Department of Biochemistry and Nutrition, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
    Previous studies have shown that serum zinc and adiponectin levels are associated with insulin resistance in the polycystic ovary syndrome (PCOS) patients. But there is no study to evaluate serum zinc and adiponectin levels as predictor markers of PCOS, adjusted for anthropometric, biochemical, dietary intake, and physical activity measures. Ninety-one new PCOS cases (based on the Rotterdam criteria) and 85 healthy control women participated and individually matched based on age. Read More

    Standardised versus individualised multiherb Chinese herbal medicine for oligomenorrhoea and amenorrhoea in polycystic ovary syndrome: a randomised feasibility and pilot study in the UK.
    BMJ Open 2017 Feb 3;7(2):e011709. Epub 2017 Feb 3.
    University of Southampton Primary Care and Population Sciences Aldermoor Health Centre Aldermoor Close, Southampton, UK.
    Objectives: To explore feasibility of a randomised study using standardised or individualised multiherb Chinese herbal medicine (CHM) for oligomenorrhoea and amenorrhoea in women with polycystic ovary syndrome (PCOS), to pilot study methods and to obtain clinical data to support sample size calculations.

    Design: Prospective, pragmatic, randomised feasibility and pilot study with participant and practitioner blinding.

    Setting: 2 private herbal practices in the UK. Read More

    The effect of alfacalcidiol and metformin on metabolic disturbances in women with polycystic ovary syndrome.
    Horm Mol Biol Clin Investig 2017 Feb 3. Epub 2017 Feb 3.
    Background: The aim of this randomized clinical trial (RCT) was to evaluate the effect of vitamin D supplementation in obese, insulin-resistant (IR) and vitamin D-deficient polycystic ovary syndrome (PCOS) women on metabolic abnormalities in comparison to the effect of metformin or combined metformin plus vitamin D therapy.

    Material And Methods: Thirty-nine PCOS women who fulfilled the inclusion criteria were randomized into three groups and treated with alfacalcidiol, combined alfacalcidiol and metformin therapy and metformin for 6 months. Body weight, body mass index (BMI), waist circumference, total body fat and fat distribution were measured before and after 6 months of treatment. Read More

    Total testosterone to dihydrotestosterone ratio assessed by LC-MS/MS predicts a worse metabolic profile not only in PCOS patients.
    Ginekol Pol 2017 ;88(1):5-8
    Department of Internal Medicine and Endocrinology, Medical University of Warsaw, Poland.
    Objectives: Total testosterone/dihydrotestosterone ratio (TT/DHT) was found to determine metabolic risk in polycystic ovary syndrome (PCOS). The aim of this study was to analyze whether (TT/DHT) may be helpful in predicting metabolic risk not only in PCOS patients but also in healthy women.

    Material And Methods: Total testosterone (TT), dihydrotestosterone (DHT), androstendione and dehydroepiandrosterone sulphate (DHEA-S) were measured by LC-MS/MS in 36 women with PCOS and in 29 age-matched controls without clinical hyperandrogenism. Read More

    A review of paediatric and adolescent gynaecology services in a tertiary outpatient clinic.
    Hum Fertil (Camb) 2017 Feb 2:1-11. Epub 2017 Feb 2.
    a Leeds Centre for Reproductive Medicine, Seacroft Hospital , Leeds , UK.
    Adolescence is a distinctive stage in human development during which many simple and complex medical conditions can present for the first time. Paediatric and adolescent gynaecological conditions need careful multidisciplinary clinical management with a sensitive approach understanding the patients' psychological and physiological circumstances. The objective of this study is to review the tertiary paediatric and adolescent gynaecology service in Leeds, United Kingdom and to present an overview of the various conditions that present to such a clinic. Read More

    Effects of human chorionic gonadotropin combined with clomiphene on Serum E2, FSH, LH and PRL levels in patients with polycystic ovarian syndrome.
    Saudi J Biol Sci 2017 Feb 9;24(2):241-245. Epub 2016 Sep 9.
    Reproductive Medicine Center, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
    Objective: Effects of human chorionic gonadotropin combined with clomiphene on serum E2, FSH, LH and PRL levels in patients with polycystic ovarian syndrome were analyzed.

    Methods: 90 patients with polycystic ovarian syndrome treated from January 2015 to March 2016 were randomly and evenly divided into control group and observation group. Patients in the control group were only treated with clomiphene. Read More

    Is cardiovascular risk in women with PCOS a real risk? Current insights.
    Minerva Endocrinol 2017 Jan 31. Epub 2017 Jan 31.
    Department of Endocrinology, Diabetes and Metabolic Diseases, Euroclinic Hospital, Athens, Greece -
    Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive aged women. PCOS incorporates not only symptoms related to the reproductive system but also a clustering of systemic metabolic abnormalities that are linked with increased risk for cardiovascular disease (CVD). More specifically, metabolic aberrations such as impaired glucose and lipid metabolism, accompanied by increased low-grade inflammation as well as elevated coagulation factors appear to contribute to the increased cardiovascular risk. Read More

    The association between paraoxonase 1 gene polymorphisms and polycystic ovarian syndrome.
    Cell Mol Biol (Noisy-le-grand) 2016 Dec 30;62(14):44-47. Epub 2016 Dec 30.
    Gynaecology of Affiliate Hospital Maternal and Child Health Care of Zunyi Medical University, Zunyi, Guizhou, China.
    Some studies investigated the association of paraoxonase 1 (PON1) polymorphisms with polycystic ovarian syndrome (PCOS) risk. However, the result was still inconsistent. The aim of this study was to investigate whether there is an association between the PON1 polymorphisms and PCOS risk. Read More

    Treatment strategies for women with WHO group II anovulation: systematic review and network meta-analysis.
    BMJ 2017 Jan 31;356:j138. Epub 2017 Jan 31.
    Robinson Research Institute, Discipline of Obstetrics and Gynaecology, School of Medicine, University of Adelaide, North Adelaide, Australia.
    Objective:  To compare the effectiveness of alternative first line treatment options for women with WHO group II anovulation wishing to conceive.

    Design:  Systematic review and network meta-analysis.

    Data Sources:  Cochrane Central Register of Controlled Trials, Medline, and Embase, up to 11 April 2016. Read More

    Short-term effectiveness of low dose liraglutide in combination with metformin versus high dose liraglutide alone in treatment of obese PCOS: randomized trial.
    BMC Endocr Disord 2017 Jan 31;17(1). Epub 2017 Jan 31.
    Department of Endocrinology, Diabetes and Metabolic Diseases, University Medical Centre Ljubljana, Zaloška 7, Ljubljana, SI-1000, Slovenia.
    Background: Liraglutide 3 mg was recently approved as an anti-obesity drug. Metformin is weight neutral, yet it could enhance the therapeutic index of GLP-1 agonist. We compared weight-lowering potential of liraglutide 1. Read More

    Probiotic supplementation and the effects on weight loss, glycaemia and lipid profiles in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial.
    Hum Fertil (Camb) 2017 Feb 1:1-8. Epub 2017 Feb 1.
    f Research Center for Biochemistry and Nutrition in Metabolic Diseases , Kashan University of Medical Sciences , Kashan , Iran.
    The aim of the current study was to assess the effects of probiotic supplementation on weight loss, glycaemia and lipid profiles in women with polycystic ovary syndrome (PCOS). In a randomized, double-blind, placebo-controlled trial, 60 women with PCOS were randomized to receive probiotic capsule (n = 30) or placebo (n = 30) for 12 weeks. Consumption of probiotic supplements resulted in a significant reduction in weight (-0. Read More

    Plasma L-carnitine levels of obese and non-obese polycystic ovary syndrome patients.
    J Obstet Gynaecol 2017 Jan 31:1-4. Epub 2017 Jan 31.
    a Faculty of Medicine, Department of Obstetrics and Gynecology , Afyon Kocatepe University , Afyonkarahisar , Turkey.
    It is well-known that plasma L-carnitine concentrations are significantly decreased in obese individuals. A study showed that L-carnitine concentrations are significantly lower in lean PCOS patients than in lean healthy women. Thus, it has been suggested that lowered L-carnitine is associated with PCOS. Read More

    [Anti-Müllerian hormone as an indicator of reproductive health in women with obesity and concomitant polycystic ovary syndrome].
    Ter Arkh 2016 ;88(12):41-44
    National Medical Holding, Astana, Republic of Kazakhstan.
    Aim: To investigate the ovarian reserve and a relationship between the level of anti-Müllerian hormone (AMH) with that of hormones in reproductive-aged women with abdominal obesity concurrent with and without polycystic ovary syndrome (PCOS).

    Subjects And Methods: A total of 157 women aged 18 to 45 years with a body mass index (BMI) of more than 30 kg/m2 were examined. The 157 women with abdominal obesity were conventionally divided into 2 groups: 1) 20 with PCOS and 2) 137 without this condition. Read More

    Association of type 2 diabetes mellitus genes in polycystic ovary syndrome aetiology among women from southern India.
    Indian J Med Res 2016 Sep;144(3):400-408
    Molecular Anthropology Group, Biological Anthropology Unit, Indian Statistical Institute, Hyderabad, India.
    Background & Objectives: Polycystic ovary syndrome (PCOS) is the most common reproductive endocrine disorder of premenopausal women. Given the phenotypic overlap between PCOS and type 2 diabetes mellitus (T2DM), this study was carried out to investigate whether genes implicated in T2DM were also involved in the susceptibility to PCOS among women from southern India.

    Methods: A total of 248 women with PCOS and 210 healthy women as controls were genotyped for a panel of 15 single nucleotide polymorphisms (SNPs) from the nine T2DM genes, such as TCF7L2, IGF2BP2, SLC30A8, HHEX, CDKAL1, CDKN2A, IRS1, CAPN10 and PPARG, on Sequenom MassARRAY platform. Read More

    Ovarian Fibrosis: A Phenomenon of Concern.
    Chin Med J (Engl) 2017 5th Feb;130(3):365-371
    Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, China.
    Objective: Ovarian fibrosis is characterized by excessive proliferation of ovarian fibroblasts and deposition of extracellular matrix (ECM) and it is one of the principal reasons for ovarian dysfunction. This review aimed to investigate the pathogenetic mechanism of ovarian fibrosis and to clarify the relationship between ovarian diseases and fibrosis.

    Data Sources: We searched PubMed for English language articles published up to November 2016. Read More

    Increased Risk of Psychiatric Disorders in Women with Polycystic Ovary Syndrome in Southwest China.
    Chin Med J (Engl) 2017 5th Feb;130(3):262-266
    Department of Obstetrics and Gynecology, West Second University Hospital, Sichuan University; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Chengdu, Sichuan 610041, China.
    Background: Polycystic ovary syndrome (PCOS) and its characteristic symptoms have been associated with physical and psychological issues in women of reproductive age. The current study was conducted in response to the dearth of systematic research related to psychological functioning and quality of life in patients with PCOS in Southwest China, and to determine whether patients with PCOS exhibit poorer mental health (MH) compared to healthy women of the same age and living in the same region, without a PCOS diagnosis.

    Methods: We enrolled 120 outpatients with PCOS and 100 healthy controls in this study. Read More

    Time-lapse imaging reveals differences in growth dynamics of embryos after in vitro maturation compared with conventional stimulation.
    Fertil Steril 2017 Jan 27. Epub 2017 Jan 27.
    Department of Gynecologic Endocrinology and Fertility Disorders, Ruprecht-Karls University of Heidelberg, Heidelberg, Germany. Electronic address:
    Objective: To study the impact of in vitro maturation (IVM) on embryonal development with the use of time-lapse imaging.

    Design: Retrospective case-control study.

    Setting: University hospital. Read More

    Dysregulation of In Vitro Decidualization of Human Endometrial Stromal Cells by Insulin via Transcriptional Inhibition of Forkhead Box Protein O1.
    PLoS One 2017 30;12(1):e0171004. Epub 2017 Jan 30.
    Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
    Insulin resistance and compensatory hyperinsulinemia are characteristic features of obesity and polycystic ovary syndrome, and both are associated with reduced fertility and implantation. There is little knowledge about the effect of insulin on the decidualization process and previous findings are contradictory. We investigated the effect of insulin on the regulation of forkhead box protein O1 (FOXO1), one of the most important transcription factors during decidualization. Read More

    Decreased expression of fatty acid amide hydrolase in women with polycystic ovary syndrome.
    Gynecol Endocrinol 2017 Jan 28:1-5. Epub 2017 Jan 28.
    a Department of Reproduction , The Second Hospital of Hebei Medical University , Shijiazhuang , China.
    This study aimed to investigate the correlation between endocannabinoids and polycystic ovary syndrome (PCOS), and the expression levels of endocannabinoids in different phases of menstruation. The expression of cannabinoid receptors (CB1) and fatty acid amide hydrolase (FAAH) in the endometrium were immunohistochemically stained and compared between women with PCOS and the control group. Integrated optical density (IOD) was assessed to analyze their expression levels. Read More

    Antiphospholipid Syndrome with Antiβ2glicoprotein-1 Antibodies as the Cause of Recurrent Tibial Vein Thrombosis in SAPHO syndrome.
    Acta Dermatovenerol Croat 2016 Dec;24(4):305-306
    Hanna Przepiera-Będzak, MD, Department of Rheumatology and Internal Diseases, Pomeranian Medical University in Szczecin, Unii Lubelskiej 1, 71-252 Szczecin, Poland.
    The antiphospholipid antibody syndrome is defined by the presence of antiphospholipid antibodies in patients with recurrent venous or arterial thromboembolism (1). SAPHO syndrome is a rare disease, characterized by specific clinical manifestations of synovitis, acne pustulosis, hyperostosis, and osteitis. It is a disease that manifests with a combination of osseous and articular manifestations associated with skin lesions (2). Read More

    Vitamin D receptor polymorphisms and the polycystic ovary syndrome: A systematic review.
    J Obstet Gynaecol Res 2017 Jan 27. Epub 2017 Jan 27.
    Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
    Polycystic ovary syndrome (PCOS) is the most frequent endocrinological disorder that affects women of reproductive age, leading to metabolic alterations, such as hyperandrogenism, obesity, menstrual irregularities, insulin resistance, and polycystic ovaries. The etiology remains unclear, but several genetic and environmental factors have been correlated with manifestations of this syndrome. Vitamin D plays important roles in metabolic pathways affected by PCOS, including calcium homeostasis, the insulin pathway, and sex hormone synthesis. Read More

    An inverse association between serum soluble receptor of advanced glycation end products and hyperandrogenism and potential implication in polycystic ovary syndrome patients.
    Reprod Biol Endocrinol 2017 Jan 26;15(1). Epub 2017 Jan 26.
    Department of Endocrinology and Metabolism, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
    Background: Studies found that AGE-RAGE system is closely related to insulin resistance and hyperandrogenemia, which are two core pathophysiological processes in polycystic ovary syndrome (PCOS). This study is to investigate the relationship among advanced glycation end-products/soluble receptor of advanced glycation end-products (AGEs/sRAGE) and anthropometric evaluation, homeostatic model assessment-insulin resistance (HOMA-IR), free androgen index (FAI) in reproductive-aged PCOS patients.

    Methods: One hundred and forty-eight Chinese women with PCOS were enrolled in this study. Read More

    Metabolomic profiling identifies potential pathways involved in the interaction of iron homeostasis with glucose metabolism.
    Mol Metab 2017 Jan 31;6(1):38-47. Epub 2016 Oct 31.
    First Department of Medicine, Paracelsus Medical University, Müllner Hauptstrasse 48, 5020 Salzburg, Austria; Obesity Research Unit, Paracelsus Medical University, Müllner Hauptstrasse 48, 5020 Salzburg, Austria.
    Objective: Elevated serum ferritin has been linked to type 2 diabetes (T2D) and adverse health outcomes in subjects with the Metabolic Syndrome (MetS). As the mechanisms underlying the negative impact of excess iron have so far remained elusive, we aimed to identify potential links between iron homeostasis and metabolic pathways.

    Methods: In a cross-sectional study, data were obtained from 163 patients, allocated to one of three groups: (1) lean, healthy controls (n = 53), (2) MetS without hyperferritinemia (n = 54) and (3) MetS with hyperferritinemia (n = 56). Read More

    New Insights into mTOR Signal Pathways in Ovarian-Related Diseases: Polycystic Ovary Syndrome and Ovarian Cancer
    Asian Pac J Cancer Prev 2016 12 1;17(12):5087-5094. Epub 2016 Dec 1.
    Institute of Biological Science, The Key Laboratory of Biological Toxicology and Ecological Restoration of Hengyang City, School of Pharmaceutical and Biological Science, University of South China, Heng yang 421001, Hunan Province, China. Email:
    mTOR, the mammalian target of rapamycin, is a conserved serine/threonine kinase which belongs to the phosphatidyl-linositol kinase-related kinase (PIKK) family. It has two complexes called mTORC1 and mTORC2. It is well established that mTOR plays important roles in cell growth, proliferation and differentiation. Read More

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