17,172 results match your criteria Polycystic Ovarian Syndrome


Improvement of embryonic development and clinical outcomes of germinal vesicle stage oocytes using a microvibration culture system.

Syst Biol Reprod Med 2019 Apr 19:1-9. Epub 2019 Apr 19.

b Division of Biotechnology , College of Life Sciences and Biotechnology, Korea University , Seongbuk-gu , Seoul , Republic of Korea.

In vitro maturation (IVM) has evolved as a clinical treatment option in assisted reproductive technology. However, the poor developmental potential of germinal vesicle (GV)-stage oocytes is still suboptimal. This study's objective was to evaluate the effect of a microvibration culture system (MVC) during IVM and/or in vitro culture (IVC) on the clinical outcomes and the embryonic development potential of human GV-stage oocytes collected from human chorionic gonadotropin (HCG)-primed IVM and fertilization-embryo transfer (IVM/F-ET) cycles of patients with polycystic ovaries (PCO). Read More

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https://www.tandfonline.com/doi/full/10.1080/19396368.2019.1
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http://dx.doi.org/10.1080/19396368.2019.1602681DOI Listing
April 2019
1 Read

Prevalence of polycystic ovary syndrome in a metabolically healthy obese population.

Int J Gynaecol Obstet 2019 Apr 19. Epub 2019 Apr 19.

Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.

Objective: To determine whether polycystic ovary syndrome (PCOS) prevalence is increased among metabolically healthy obese (MHO) women.

Methods: A national epidemiologic survey in 10 provinces and municipalities of China between October 2007 and September 2011. Women were stratified into four groups according to metabolic health (Assessment by Adult Treatment Panel III) and obesity (body mass index [BMI] ≥28): metabolically healthy nonobese (MHNO), metabolically unhealthy nonobese (MUNO), MHO, and metabolically unhealthy obese (MUO). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ijgo.12824
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http://dx.doi.org/10.1002/ijgo.12824DOI Listing
April 2019
1 Read

Effects of Exercise Combined with Finasteride on Hormone and Ovarian Function in Polycystic Ovary Syndrome Rats.

Int J Endocrinol 2019 13;2019:8405796. Epub 2019 Mar 13.

Department of Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Exercise can reduce androgen and insulin levels in polycystic ovary syndrome (PCOS) patients. Finasteride is also presumed to improve the developing follicle environment. Therefore, the aim of this study was to observe the effects of the combination of exercise and finasteride therapy on hormone levels and ovarian morphology in rats with polycystic ovary syndrome. Read More

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http://dx.doi.org/10.1155/2019/8405796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436361PMC

The Effect of Exenatide on Cardiovascular Risk Markers in Women With Polycystic Ovary Syndrome.

Front Endocrinol (Lausanne) 2019 2;10:189. Epub 2019 Apr 2.

Weill Cornell Medicine Qatar, Education City, Doha, Qatar.

Polycystic ovary syndrome (PCOS) is associated with an adverse cardiovascular risk profile including a prothrombotic state. Exenatide has been shown to be effective at improving insulin sensitivity and weight loss in PCOS; therefore this study was undertaken to assess its effects on weight, endothelial function, inflammatory markers, and fibrin structure/function in overweight/obese women with PCOS. Thirty overweight/obese anovulatory women with all 3 Rotterdam criteria received exenatide 5 mcg bd for 4 weeks then 10 mcg bd for 12 weeks. Read More

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https://www.frontiersin.org/article/10.3389/fendo.2019.00189
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http://dx.doi.org/10.3389/fendo.2019.00189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454834PMC
April 2019
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A Low Glycemic Index Decreases Inflammation by Increasing the Concentration of Uric Acid and the Activity of Glutathione Peroxidase (GPx3) in Patients with Polycystic Ovary Syndrome (PCOS).

Molecules 2019 Apr 17;24(8). Epub 2019 Apr 17.

Department of Immunology, Microbiology and Physiological Chemistry, West Pomeranian University of Technology, 70-310 Szczecin, Poland.

Introduction: According to a review of the literature, there is a lack of data on the mechanisms that participate in the suppression of inflammation that accompanies polycystic ovary syndrome (PCOS). Additionally, the changes in oxidative status resulting from a low-calorie diet have not been studied in a group of women with PCOS, and the oxidation and reduction processes associated with PCOS have not been explained.

Material And Methods: The study involved 49 women who were diagnosed with PCOS according to Rotterdam's criteria, and 24 women voluntarily agreed to a three-month dietary intervention. Read More

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https://www.mdpi.com/1420-3049/24/8/1508
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http://dx.doi.org/10.3390/molecules24081508DOI Listing
April 2019
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Obesity Induces Ovarian Inflammation and Reduces Oocyte Quality.

Reproduction 2019 Apr 1. Epub 2019 Apr 1.

J Wood, Animal Science, University of Nebraska, Lincoln, 68583-0908, United States.

In the US, 36.5 percent of women between the ages of 20-39 are obese. This obesity results in not only metabolic disorders including type II diabetes and cardiovascular disease, but also impaired female fertility. Read More

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https://rep.bioscientifica.com/view/journals/rep/aop/rep-18-
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http://dx.doi.org/10.1530/REP-18-0583DOI Listing
April 2019
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Estrogenic properties of genistein acting on FSHR and LHR in rats with PCOS.

Authors:
T Zhang X X Chi

Pol J Vet Sci 2019 Mar;22(1):83-90

College of Food Science, Heilongjiang Bayi Agricultural University, Daqing, Heilongjiang Province 163319, China.

The purpose of the study was to study the activity of the phytoestrogen genistein (GEN) act- ing on FSHR and LHR in rat ovaries with polycystic ovary syndrome (PCOS). Sixty rats were di- vided into six groups. Rats in the dose group received genistein at a concentration of either 5 (low genistein dose group, L-gen), 10 (middle genistein dose group, M-Gen) or 20 (high genistein dose group, H-Gen) mg per kg of body weight per day. Read More

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http://journals.pan.pl/dlibra/publication/127075
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http://dx.doi.org/10.24425/pjvs.2019.127075DOI Listing
March 2019
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Animal models of polycystic ovary syndrome: A review of hormone-induced rodent models focused on hypothalamus-pituitary-ovary axis and neuropeptides.

Reprod Med Biol 2019 Apr 28;18(2):151-160. Epub 2018 Dec 28.

Department of Obstetrics and Gynecology Nagoya University Graduate School of Medicine Nagoya Japan.

Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder among women of reproductive age and a major cause of infertility; however, the pathophysiology of this syndrome is not fully understood. This can be addressed using appropriate animal models of PCOS. In this review, we describe rodent models of hormone-induced PCOS that focus on the perturbation of the hypothalamic-pituitary-ovary (HPO) axis and abnormalities in neuropeptide levels. Read More

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http://dx.doi.org/10.1002/rmb2.12262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452010PMC

Sleep disorders in polycystic ovary syndrome: influence of obesity and hyperandrogenism.

Rev Assoc Med Bras (1992) 2019 Mar 11;65(3):375-383. Epub 2019 Apr 11.

Department of Psychobiology, Federal University of Sao Paulo, Sao Paulo, SP, Brasil.

Objective: This study aims to evaluate the sleep of subjects with polycystic ovary syndrome (PCOS), with and without hyperandrogenism, in comparison with a healthy control group and examine the effects of hyperandrogenism and obesity on sleep parameters.

Methods: A total of 44 volunteers were recruited to participate in the study. Clinical, biochemical and polysomnographic parameters were used to diagnose PCOS and hyperandrogenism. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/1806-9282.65.3.375DOI Listing
March 2019
2 Reads

Polycystic Ovary Syndrome and Cardiovascular Diseases: Still an Open Door.

Arq Bras Cardiol 2019 Apr;112(4):430-431

Faculdade de Ciencias Medicas de Minas Gerais, Belo Horizonte, MG - Brazil.

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http://www.gnresearch.org/doi/10.5935/abc.20190062
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http://dx.doi.org/10.5935/abc.20190062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459439PMC
April 2019
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Contemporary Management of Polycystic Ovarian Syndrome.

Clin Obstet Gynecol 2019 Apr 15. Epub 2019 Apr 15.

The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, New York, New York.

PCOS remains one of the most intriguing endocrine disorders that physicians encounter even though it was first described over 80 years ago. Although the diagnostic criteria, nomenclature, and ideal therapeutic strategies are areas of active and ongoing debate, there is no doubt that we have made tremendous progress in improving the quality of life and reproductive outcomes of women who suffer from this wide-ranging disorder. Read More

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http://dx.doi.org/10.1097/GRF.0000000000000449DOI Listing
April 2019
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The effect of myo-inositol/di-chiro-inositol on markers of ovarian reserve in women with PCOS undergoing IVF/ICSI: a systematic review and meta-analysis.

Acta Obstet Gynecol Scand 2019 Apr 16. Epub 2019 Apr 16.

Women's Health and Perinatology Research Group, Department of Clinical Medicine, UiT-The Arctic University of Norway, Tromsø, Norway.

Introductio: High levels of anti-Mullerian hormone and a high antral follicle count in women with polycystic ovary syndrome, reflecting increased ovarian antral follicles, predisposes them to have a high number of retrieved oocytes at in-vitro fertilisation (IVF)/ intra-cytoplasmic sperm injection (ICSI) and an increased risk of ovarian hyperstimulation syndrome. Inositols, which act as insulin sensitizers have the potential to alter folliculogenesis and the functional ovarian reserve with subsequent benefits to reproductive outcomes following IVF/ICSI treatment. Published literature is however unable to provide definitive evidence of its efficacy. Read More

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http://dx.doi.org/10.1111/aogs.13625DOI Listing

Activation profiles of monocyte-macrophages and HDL function in healthy women in relation to menstrual cycle and in polycystic ovary syndrome patients.

Endocrine 2019 Apr 16. Epub 2019 Apr 16.

Department of Medicine, University of Padova, Padova, Italy.

Purpose: Hormonal status and menopause affect human macrophage function and cardiometabolic risk. In polycystic ovary syndrome (PCOS) patients the cardiometabolic risk increases through mechanisms that are largely unknown. We tested the hypotheses that macrophage activation is influenced by menstrual cycle and that ovarian dysfunction in PCOS patients is associated with altered macrophage inflammatory responses and cholesterol efflux capacity of serum HDL. Read More

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http://dx.doi.org/10.1007/s12020-019-01911-2DOI Listing
April 2019
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PGC-1α protects against oxidized low-density lipoprotein and luteinizing hormone-induced granulosa cells injury through ROS-p38 pathway.

Hum Cell 2019 Apr 16. Epub 2019 Apr 16.

Department of Gynaecology and Obstetrics, Beijing United Family Hospital, Beijing, 100016, China.

Obese women with polycystic ovary syndrome (PCOS) often suffer from ovulation failure, which may be driven by granulosa cells (GCs) injury caused by increased levels of circulating oxidized low-density lipoprotein (ox-LDL) and luteinizing hormone (LH). PGC-1α may play an important role in this pathophysiological processes. However, the effect and the potential mechanism of PGC-1α on GCs injury evoked by obese PCOS is fully unclear. Read More

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http://dx.doi.org/10.1007/s13577-019-00252-6DOI Listing
April 2019
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Association of Kiss1 and GPR54 Gene Polymorphisms with Polycystic Ovary Syndrome among Sri Lankan Women.

Biomed Res Int 2019 12;2019:6235680. Epub 2019 Mar 12.

Department of Obstetrics and Gynecology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.

Polycystic ovary syndrome (PCOS) is the commonest endocrine disorder affecting women of reproductive age. Its aetiology, though yet unclear, is presumed to have an oligogenic basis interacting with environmental factors. Kisspeptins are peptide products of Kiss1 gene that control the hypothalamic pituitary (HPG) axis by acting via G protein-coupled receptor known as GPR54. Read More

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https://www.hindawi.com/journals/bmri/2019/6235680/
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http://dx.doi.org/10.1155/2019/6235680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434290PMC
March 2019
5 Reads

The effectiveness of high intensity intermittent training on metabolic, reproductive and mental health in women with polycystic ovary syndrome: study protocol for the iHIT- randomised controlled trial.

Trials 2019 Apr 16;20(1):221. Epub 2019 Apr 16.

Institute for Health and Sport, Victoria University, PO Box 14428, Melbourne, Victoria, 8001, Australia.

Background: Polycystic ovary syndrome (PCOS) is a reproductive-metabolic condition. Insulin resistance is a hallmark of PCOS and is related to increased hyperandrogenism that drives inherent metabolic, reproductive and psychological features of the syndrome. Insulin resistance in women with PCOS is managed by weight loss, lifestyle interventions (i. Read More

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http://dx.doi.org/10.1186/s13063-019-3313-8DOI Listing
April 2019
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Widding the Use of Insulin Sensitizers to Patients with Polycystic Ovarian Syndrome-A Late, but Wise Decision.

Rev Bras Ginecol Obstet 2019 Mar 16;41(3):137-141. Epub 2019 Apr 16.

Department of Gynecology and Obstetrics, Faculty of Medicine, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.

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http://dx.doi.org/10.1055/s-0039-1685482DOI Listing
March 2019
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Afamin predicts gestational diabetes in polycystic ovary syndrome patients preconceptionally.

Endocr Connect 2019 Apr 1. Epub 2019 Apr 1.

H Dieplinger, Genetic Epidemiology, Innsbruck Medical University, Innsbruck, A-6020, Austria.

Background: Patients suffering from polycystic ovary syndrome (PCOS) are often insulin-resistant and at elevated risk for developing gestational diabetes mellitus (GDM). The aim of this study was to explore afamin, which can be determined preconceptionally to indicate patients who will subsequently develop GDM. Serum concentrations of afamin are altered in conditions of oxidative stress like insulin resistance (IR) and correlate with the gold standard of IR determination, the HOMA index. Read More

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https://ec.bioscientifica.com/view/journals/ec/aop/ec-19-006
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http://dx.doi.org/10.1530/EC-19-0064DOI Listing
April 2019
3 Reads

A Clinical Evidence of a Correlation Between Insulin Resistance and the ALCAT Food Intolerance Test.

Altern Ther Health Med 2019 Mar;25(2):22-38

Insulin resistance (IR) is defined as the inability of a known quantity of exogenous or endogenous insulin to increase glucose uptake and utilization. Several mechanisms have been proposed as possible causes underlying the development of IR and the IR syndrome. IR occurs as part of a cluster of cardiovascular-metabolic abnormalities commonly referred to as "The Metabolic Syndrome. Read More

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March 2019
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[Diagnostic criteria for polycystic ovary syndrome].

Ugeskr Laeger 2019 Apr;181(15)

Since 2004, the Rotterdam criteria have been used in the diagnosis of polycystic ovary syndrome (PCOS), requiring the presence of two of the following three criteria: oligo-/anovulation, hyperandrogenism or polycystic ovaries. Reports of high prevalences of polycystic ovaries in younger women have caused concerns about overdiagnosis. Recently, the international guideline for PCOS has recommended raising the follicle threshold for polycystic ovaries and avoiding ultrasound in adolescents. Read More

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April 2019
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High prevalence of benign mammary tumors in a rat model of polycystic ovary syndrome during postmenopausal period.

Gynecol Endocrinol 2019 Apr 16:1-6. Epub 2019 Apr 16.

a Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences , Tehran , Iran.

Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in reproductive-age women. Significant associations between PCOS and benign breast diseases (BBD) and a possibly potential association between PCOS and breast cancer have been reported. The etiology of these events of mammary glands in PCOS remains unclear. Read More

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http://dx.doi.org/10.1080/09513590.2019.1576613DOI Listing
April 2019
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[Bushen Huoxue herbal medicine in subfertile women with polycystic ovary syndrome: a Meta-analysis].

Zhongguo Zhong Yao Za Zhi 2019 Mar;44(6):1080-1086

Xiyuan Hospital,China Academy of Chinese Medicine Sciences Beijing 100091,China.

Meta-analysis of randomized controlled trials( RCTs) was conducted to clarify the effect of Bushen Huoxue herbal medicine in subfertile women with polycystic ovary syndrome. Databases including CNKI,Wan Fang,VIP,Sino Med,PubMed,EMbase,the Cochrane Library were searched until September,2018. Two reviewers independently assessed study eligibility,extracted data,and evaluated the risk of bias for included trials. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.2019.0021DOI Listing
March 2019
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Metformin treatment alleviates polycystic ovary syndrome by decreasing the expression of MMP-2 and MMP-9 via H19/miR-29b-3p and AKT/mTOR/autophagy signaling pathways.

J Cell Physiol 2019 Apr 15. Epub 2019 Apr 15.

Department of Obstetrics and Gynecology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

In this study, we aimed to investigate the molecular pathway(s) underlying the effect of metformin (MET) on the expression of matrix metalloproteinase (MMP)-2 and MMP-9. Real-time polymerase chain reaction, Western blot analysis, and gelatin zymography were used to assay the effects of MET on MMP and AMPK signaling pathways. In addition, HTOG cells were treated with miR-29b-3p/a scramble control, H19/a negative control, or MET/PBS to explore possible signaling pathway(s) underlying the inhibitory effect of MET on MMP-2/MMP-9. Read More

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http://dx.doi.org/10.1002/jcp.28594DOI Listing
April 2019
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Phosphodiesterase 4 inhibitor plus metformin is superior to metformin alone for the treatment of polycystic ovary syndrome: A rat model study.

Exp Ther Med 2019 May 22;17(5):4013-4022. Epub 2019 Mar 22.

Department of Obstetrics and Gynecology, Başkent University School of Medicine, 06490 Ankara, Turkey.

The role of metformin in the management of polycystic ovary syndrome (PCOS) and PCOS-related obesity remains controversial. Recent research on the treatment of PCOS-related obesity investigated novel therapeutic agents with the potential to work synergistically with metformin. The aim of the present study was to determine the synergistic effect of a phosphodiesterase 4 inhibitor (PDE4i) and metformin on weight and hormonal changes in a rat model of PCOS. Read More

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http://dx.doi.org/10.3892/etm.2019.7428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447905PMC
May 2019
2 Reads

Tanshinone IIA attenuates estradiol-induced polycystic ovarian syndrome in mice by ameliorating FSHR expression in the ovary.

Exp Ther Med 2019 May 6;17(5):3501-3508. Epub 2019 Mar 6.

Department of Gynecology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, P.R. China.

Tanshinone IIA (TSIIA) is a major component of , a Chinese herb that exhibits a therapeutic effect on polycystic ovary syndrome (PCOS). The present study replicated PCOS via the neonatal treatment of estradiol in mice. Estrous cycles, body and ovarian weight, serum levels of testosterone and estradiol were determined. Read More

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http://dx.doi.org/10.3892/etm.2019.7352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447779PMC
May 2019
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Detection of T lymphocyte subsets and related functional molecules in follicular fluid of patients with polycystic ovary syndrome.

Sci Rep 2019 Apr 15;9(1):6040. Epub 2019 Apr 15.

Reproductive medical center, Guangdong Women and Children Hospital, Guangzhou Medical University, 511400, Guangzhou, China.

Immune responses play an important role in the pathogenesis of polycystic ovary syndrome (PCOS). However, the characteristics of T lymphocyte subsets in PCOS remain insufficiently understood. In this study, lymphocytes of follicular fluid (FF) were obtained from oocyte retrieval before in-vitro fertilization (IVF) in infertile women with or without PCOS. Read More

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http://dx.doi.org/10.1038/s41598-019-42631-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465402PMC
April 2019
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Depression over the lifespan in a population-based cohort of women with polycystic ovary syndrome: longitudinal analysis.

J Clin Endocrinol Metab 2019 Apr 15. Epub 2019 Apr 15.

Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, CA.

Purpose: To 1) determine whether women with polycystic ovary syndrome (PCOS) from a population-based cohort experience elevated depression symptoms, and 2) characterize the trajectory of symptoms over the lifespan.

Methods: The association between PCOS and longitudinal depression scores was investigated among 1,127 black and white women participating in Coronary Artery Risk Development in Young Adults (CARDIA) study. PCOS was ascertained at baseline (ages 20-32) by NIH criteria, incorporating androgens and symptoms of oligomenorrhea and hirsutism. Read More

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http://dx.doi.org/10.1210/jc.2019-00234DOI Listing
April 2019
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Effects of omega-3 polyunsaturated fatty acids on steroidogenesis and cellular development in PCOS rats.

Food Funct 2019 Apr 15. Epub 2019 Apr 15.

Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University (BTBU), Beijing 100048, Peoples' Republic of China. and College of Life Science, Capital Normal University, Beijing 100048, Peoples' Republic of China.

Polycystic ovary syndrome (PCOS) is a common endocrine disorder, which is characterized by hyperandrogenism. Polyunsaturated fatty acids (PUFAs) are necessary for the body's metabolism, growth and development. Despite the well-known benefits of omega-3 polyunsaturated fatty acid supplementation on the modulation of PCOS ovarian function, relatively little is known about the precise regulation mechanism. Read More

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http://dx.doi.org/10.1039/c8fo02319kDOI Listing
April 2019
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Update on Management of Polycystic Ovarian Syndrome for Dermatologists.

Indian Dermatol Online J 2019 Mar-Apr;10(2):97-105

Department of Obstetrics and Gynaecology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Polycystic ovarian syndrome (PCOS) is the commonest endocrine disorder in women having wide range of clinical manifestation. These women may present with reproductive, dermatological, metabolic, psychological, or neoplastic implications from adolescence to menopause. The common dermatological manifestations include hirsutism, acne, alopecia, or acanthosis nigricans. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_249_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434760PMC

Circulating Endothelial Microparticles Reduce in Concentration Following an Exercise Programme in Women With Polycystic Ovary Syndrome.

Front Endocrinol (Lausanne) 2019 29;10:200. Epub 2019 Mar 29.

Sport, Health and Exercise Science, Faculty of Health Sciences, University of Hull, Kingston upon Hull, United Kingdom.

Endothelial dysfunction is a known comorbidity in women with polycystic ovary syndrome (PCOS). The aim was to assess if supervised, moderate intensity exercise could potentially impact markers of endothelial disruption; endothelial cell derived microparticles (EMP). The current study investigated the effects of a supervised 8-week moderate intensity exercise programme on EMP in women with PCOS ( = 11) and control women free from any known disease ( = 10). Read More

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https://www.frontiersin.org/article/10.3389/fendo.2019.00200
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http://dx.doi.org/10.3389/fendo.2019.00200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450458PMC
March 2019
2 Reads

Effectiveness and Safety of Metformin versus Canthex™ in Patients with Acanthosis Nigricans: A Randomized, Double-blind Controlled Trial.

Indian J Dermatol 2019 Mar-Apr;64(2):115-121

Department of Dermatology, Bankura Sammilani Medical College, Bankura, West Bengal, India.

Background: Acanthosis nigricans has been associated with conditions of insulin resistance such as obesity, polycystic ovary syndrome, and type 2 diabetes. Metformin and alpha-lipoic acid, two types of insulin-sensitizing agents, have been demonstrated to reduce insulin levels and improve insulin sensitivity. Alpha-lipoic acid is available as a fixed-dose combination with biotin, calcium pantothenate, and zinc sulfate as Canthex™. Read More

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http://dx.doi.org/10.4103/ijd.IJD_417_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440186PMC
April 2019
1 Read

Arterial stiffness measured by cardio-ankle vascular index in Korean women with polycystic ovary syndrome.

J Obstet Gynaecol 2019 Apr 15:1-6. Epub 2019 Apr 15.

b The Institute of Reproductive Medicine and Population Medical Research Centre , Seoul National University College of Medicine , Seoul , Korea.

Many studies have reported an increased arterial stiffness using pulse wave velocity (PWV) in women with polycystic ovary syndrome (PCOS). However, PWV is essentially dependent on blood pressure (BP) at the time of measurement. The cardio-ankle vascular index (CAVI) is a relatively new index for measuring arterial stiffness, and its conspicuous feature is its independency from the BP at the time of measurement. Read More

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http://dx.doi.org/10.1080/01443615.2018.1561654DOI Listing
April 2019
1 Read

Long non-coding RNA H19 is associated with polycystic ovary syndrome in Chinese women: a preliminary study.

Endocr J 2019 Apr 13. Epub 2019 Apr 13.

Department of Obstetrics and Gynecology, the First Clinical Medical College of Jinan University, Guangzhou, Guangdong 510632, China.

Polycystic ovary syndrome (PCOS) represents a serious reproductive and endocrine condition and is associated with high incidence rates. H19 is a compelling long noncoding RNA (lncRNA) which carries out a range of biological functions. However, prior to this study, little was known as to whether there was an association between lncRNA H19 and PCOS. Read More

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http://dx.doi.org/10.1507/endocrj.EJ19-0004DOI Listing
April 2019
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Serum and follicular fluid irisin levels in women with polycystic ovaries undergoing ovarian stimulation: correlation with insulin resistance and lipoprotein lipid profiles.

Gynecol Endocrinol 2019 Apr 15:1-4. Epub 2019 Apr 15.

a Department of Biopathology - Microbiology and Biochemistry , Aretaieion Hospital National and Kapodistrian University of Athens , Athens , Greece.

Irisin, a novel exercise-induced myokine, has been implicated in different aspects of human metabolism and could be connected to polycystic ovary syndrome (PCOS). This study aimed to investigate serum and follicular fluid (FF) irisin levels in PCOS and normal women undergoing controlled ovarian stimulation and correlate them to the lipid and lipoprotein levels as well as with other metabolic parameters. Serum and FF irisin, together with serum lipid and lipoprotein levels were assessed in 70 women with diagnosed PCOS and 70 non-PCOS controls, under in vitro fertilization (IVF) treatment. Read More

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http://dx.doi.org/10.1080/09513590.2019.1594761DOI Listing
April 2019
1 Read

Peroxiredoxin 4 levels in patients with PCOS and/or obesity.

J Gynecol Obstet Hum Reprod 2019 Apr 11. Epub 2019 Apr 11.

Medical University-Sofia, Bulgaria Department of Internal Medicine, Clinic of Endocrinology, University Hospital "Alexandrovska", Bulgaria.

Background: Peroxiredoxin 4 is a part of endogen antioxidant system and its levels are elevated in increased oxidative stress conditions. It is found to be positively associated with cardiovascular risk. The aim of the study was to investigate peroxiredoxin 4 levels in women with polycystic ovarian syndrome (PCOS) and/or obesity. Read More

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http://dx.doi.org/10.1016/j.jogoh.2019.04.002DOI Listing
April 2019
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Medical conditions, pregnancy perspectives, and contraceptive decision-making among young people: an exploratory, qualitative analysis.

Contraception 2019 Apr 10. Epub 2019 Apr 10.

Sexual Health and Reproductive Equity Program, School of Social Welfare, University of California, Berkeley, 110 Haviland Hall MC 7400, Berkeley, CA 94720-7400, USA.

Objective: To explore perspectives on family planning among young people who perceive they are infertile or will have difficulty carrying a pregnancy to term owing to medical conditions or procedures.

Methods: This exploratory analysis examined pregnancy plans and contraceptive behavior among 12 young adults with a diagnosed medical condition or who had undergone a medical procedure associated with impaired fertility, and who had discussed fertility with a healthcare provider. We utilized data from a larger study investigating prospective pregnancy intentions and plans among 50 young (ages 18-24) women and their male partners (n=100). Read More

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http://dx.doi.org/10.1016/j.contraception.2019.03.046DOI Listing
April 2019
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[Sex and gender-specific aspects in prediabetes and diabetes mellitus-clinical recommendations (Update 2019)].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

Interne Abteilung, Landeskrankenhaus Hochzirl - Natters, Hochzirl, Österreich.

Metabolic diseases dramatically affect the life of men and women from infancy up to old age in different and manifold ways and are a major challenge for the healthcare system. The treating physicians are confronted with the different needs of women and men in the clinical routine. Gender-specific differences affect screening, diagnostic and treatment strategies as well as the development of complications and mortality rates. Read More

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http://dx.doi.org/10.1007/s00508-018-1421-1DOI Listing
April 2019
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Effects of hyperhomocysteinaemia and metabolic syndrome on reproduction in women with polycystic ovary syndrome: a secondary analysis.

Reprod Biomed Online 2019 Jan 18. Epub 2019 Jan 18.

First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China. Electronic address:

Research Question: What is the association between hyperhomocysteinaemia (HHCY), metabolic syndrome, and reproductive outcomes among women with polycystic ovary syndrome (PCOS).

Design: A secondary analysis of PCOSAct with 21 sites in China. A total of 1000 women with PCOS were enrolled; 936 women with baseline homocysteine (HCY) were analysed. Read More

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http://dx.doi.org/10.1016/j.rbmo.2018.12.046DOI Listing
January 2019
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Characterization of circular RNA expression profiles in cumulus cells from patients with polycystic ovary syndrome.

Fertil Steril 2019 Apr 9. Epub 2019 Apr 9.

Reproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China. Electronic address:

Objective: To determine aberrant circular RNA (circRNA) expression profiles in cumulus cells from polycystic ovarian syndrome (PCOS) patients and identify their potential biological functions.

Design: Circular RNAs microarray analysis of human tissue.

Setting: University hospital. Read More

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http://dx.doi.org/10.1016/j.fertnstert.2019.02.023DOI Listing
April 2019
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Effects of Chromium and Carnitine Co-supplementation on Body Weight and Metabolic Profiles in Overweight and Obese Women with Polycystic Ovary Syndrome: a Randomized, Double-Blind, Placebo-Controlled Trial.

Biol Trace Elem Res 2019 Apr 11. Epub 2019 Apr 11.

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I.R., Iran.

The primary aim of our study was to determine the influence of taking chromium plus carnitine on insulin resistance, with a secondary objective of evaluating the influences on lipid profiles and weight loss in overweight subjects with polycystic ovary syndrome (PCOS). In a 12-week randomized, double-blind, placebo-controlled clinical trial, 54 overweight women were randomly assigned to receive either supplements (200 μg/day chromium picolinate plus 1000 mg/day carnitine) or placebo (27/each group). Chromium and carnitine co-supplementation decreased weight (- 3. Read More

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http://dx.doi.org/10.1007/s12011-019-01720-8DOI Listing
April 2019
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Postprandial inflammatory responses after oral glucose, lipid and protein challenges: Influence of obesity, sex and polycystic ovary syndrome.

Clin Nutr 2019 Apr 1. Epub 2019 Apr 1.

Diabetes, Obesity and Human Reproduction Research Group, Department of Endocrinology & Nutrition, Hospital Universitario Ramón y Cajal, Universidad de Alcalá & Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, Spain. Electronic address:

Background & Aims: Most evidence linking the polycystic ovary syndrome (PCOS) with chronic low-grade inflammation has been obtained in the fasting state. We have studied the postprandial inflammatory response to oral glucose, lipid and protein challenges and the possible influences of obesity, sex and PCOS on these responses.

Methods: On alternate days, we submitted 17 women with PCOS (9 non-obese, 8 obese), 17 control women (9 non-obese, 8 obese) and 19 control men (10 non-obese, 9 obese) to isocaloric (300 Kcal) oral macronutrient loads. Read More

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http://dx.doi.org/10.1016/j.clnu.2019.03.027DOI Listing
April 2019
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DNA methylome profiling of granulosa cells reveals altered methylation in genes regulating vital ovarian functions in polycystic ovary syndrome.

Clin Epigenetics 2019 Apr 11;11(1):61. Epub 2019 Apr 11.

Department of Molecular Endocrinology, ICMR-National Institute for Research in Reproductive Health, J.M. Street, Parel, Mumbai, Maharashtra, 400012, India.

Background: Women with polycystic ovary syndrome (PCOS) manifest a host of ovarian defects like impaired folliculogenesis, anovulation, and poor oocyte quality, which grossly affect their reproductive health. Addressing the putative epigenetic anomalies that tightly regulate these events is of foremost importance in this disorder. We therefore aimed to carry out DNA methylome profiling of cumulus granulosa cells and assess the methylation and transcript expression profiles of a few differentially methylated genes contributing to ovarian defects in PCOS. Read More

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https://clinicalepigeneticsjournal.biomedcentral.com/article
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http://dx.doi.org/10.1186/s13148-019-0657-6DOI Listing
April 2019
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Role of the proportion of dominant follicles in patients with PCOS undergoing in vitro fertilization-embryo transfer.

Chin Med J (Engl) 2019 Apr 3. Epub 2019 Apr 3.

Reproductive Center, Department of Gynecology and Obstetrics, Sun Yat-sen University, Guangzhou, Guangdong 510120, China.

Background: There is no absolute consensus for the best time for triggering. The aim of this study was to investigate the effect of different proportion of dominant follicles (PDF) on the human chorionic gonadotropin (HCG) day for the clinical outcomes in patients with polycystic ovary syndrome (PCOS) of different ovarian stimulation protocols.

Methods: A total of 371 cycles of the gonadotropin-releasing hormone (GnRH) agonist long protocol and 347 cycles of GnRH antagonist protocol from January, 2014 to December, 2016 were included in this retrospective study. Read More

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http://dx.doi.org/10.1097/CM9.0000000000000246DOI Listing
April 2019
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Biomarkers of Endothelial Dysfunction in Women With Polycystic Ovary Syndrome.

Angiology 2019 Apr 10:3319719840091. Epub 2019 Apr 10.

1 First Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of childbearing age. The criteria required for the diagnosis identify various phenotypes, with different reproductive, metabolic, and cardiovascular (CV) risk characteristics. Emerging evidence links adipocyte-secreted hormones as candidates in the pathogenesis of endothelial dysfunction in PCOS, independently of additional risk factors. Read More

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http://dx.doi.org/10.1177/0003319719840091DOI Listing
April 2019
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Decreased Serum Kruppel-Like Factor 7 Level is Positively Associated with Low-Density Lipoprotein Cholesterol Level in Women with Polycystic Ovary Syndrome.

Clin Lab 2019 Apr;65(4)

Background: Kruppel-like factor 7 (KLF7) is associated with type 2 diabetes and obesity; however, at present the KLF7 level in polycystic ovary syndrome (PCOS) remains unreported.

Methods: In this study, serum KLF7, glucose, insulin, C-reactive protein (CRP), follicle-stimulating hormone (FSH), luteinizing hormone (LH), and total testosterone concentrations were measured in 65 women with PCOS and 61 healthy controls.

Results: Body mass index (BMI) in PCOS and the control group were all < 25 kg/m2. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180908DOI Listing
April 2019
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Polycystic Ovary Syndrome and Insulin Physiology: An Observational Quantitative Serum Proteomics Study in adolescent, Normal-Weight Females.

Proteomics Clin Appl 2019 Apr 9:e1800184. Epub 2019 Apr 9.

Institute for Life Sciences, University of Southampton, Southampton, UK.

Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder associated with insulin resistance, even in the absence of overweight/obesity. The aim of the present study was to examine the global serum proteomic profile of adolescent, normal-weight females with PCOS in order to gain novel insight in the association of this endocrine disorder with insulin physiology but also identify novel circulating markers that can guide intervention protocols.

Methods: Non-depleted serum from normal-weight (BMI: 18-23 kg/m ), adolescent females (13 to 21 years old) with PCOS (n = 20) was compared to BMI- and age-matched healthy controls (n = 20) using our three-dimensional quantitative proteomics methodology. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/prca.2018001
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http://dx.doi.org/10.1002/prca.201800184DOI Listing
April 2019
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CFTR and FOXO1 gene expression are reduced and high mobility group box 1 (HMGB1) is increased in the ovaries and serum of women with polycystic ovarian syndrome.

Gynecol Endocrinol 2019 Apr 9:1-5. Epub 2019 Apr 9.

a Division of Pediatric Endocrinology and Diabetology, Department of Obstetrics, Gynecology and Pediatrics , Azienda USL - IRCCS di Reggio Emilia , Reggio Emilia , Italy.

We previously described increased HMGB1 and reduced FOXO1 dependent on CFTR loss of function in cystic fibrosis (CF) and we showed in vitro that HMGB1 was lowered by insulin. Reduced CFTR gene expression has been described in granulosa cells (GC) from PCOS-induced rats. We aimed at studying CFTR and FOXO1 gene expression in GC, HMGB1 concentrations in serum and follicular fluids (FF), and insulin and IL-6 in FF in PCOS women. Read More

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http://dx.doi.org/10.1080/09513590.2019.1599349DOI Listing
April 2019
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Effect of six-month use of oral contraceptive pills on plasminogen activator inhibitor-1 & factor VIII among women with polycystic ovary syndrome: An observational pilot study.

Indian J Med Res 2018 Dec;148(Supplement):S151-S155

Department of Clinical Biochemistry/Biochemistry, University of Kashmir, Srinagar, India.

Background & Objectives: Polycystic ovary syndrome (PCOS) is an endocrinopathy warranting lifelong individualized management by lifestyle and pharmacological agents mainly oral contraceptive pills (OCPs). This study was aimed to report the impact of six-month OCP use on plasminogen activator inhibitor-1 (PAI-1) and factor VIII (FVIII) in women with PCOS.

Methods: PCOS women diagnosed on the basis of Rotterdam 2003 criteria, either treated with OCPs (ethinyl estradiol-0. Read More

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http://dx.doi.org/10.4103/ijmr.IJMR_1899_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469381PMC
December 2018
3 Reads

Successful treatment of one case of pemphigoid gestationis complicating with polycystic ovary syndrome.

Dermatol Ther 2019 Apr 8:e12898. Epub 2019 Apr 8.

Department of Dermatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.

Pemphigoid gestationis (PG) is a rare, autoimmune, subepidermal bullous dermatosis associated with pregnancy. It's mainly caused by autoantibodies against hemidesmosomal proteins - bullous pemphigoid 180, and usually presents in the second or third trimester of pregnancy sometimes exacerbates spontaneously after delivery. Here we reported a case of PG with polycystic ovary syndrome. Read More

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http://dx.doi.org/10.1111/dth.12898DOI Listing
April 2019
3 Reads
1.478 Impact Factor

The Effects of Selenium Supplementation on Clinical Symptoms and Gene Expression Related to Inflammation and Vascular Endothelial Growth Factor in Infertile Women Candidate for In Vitro Fertilization.

Biol Trace Elem Res 2019 Apr 8. Epub 2019 Apr 8.

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, IR, Iran.

This study was performed to determine the effects of selenium supplementation on clinical symptoms and gene expression related to inflammatory markers in infertile women with polycystic ovary syndrome (PCOS) who were candidate for in vitro fertilization (IVF). Thirty-six women candidate for IVF were recruited in this randomized double-blinded, placebo-controlled trial. They (n = 18/group) were randomly assigned into intervention groups to take either 200 μg/day of selenium or placebo for 8 weeks. Read More

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http://link.springer.com/10.1007/s12011-019-01715-5
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http://dx.doi.org/10.1007/s12011-019-01715-5DOI Listing
April 2019
2 Reads