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    Vitamin D3 regulates steroidogenesis in granulosa cells through AMP-activated protein kinase (AMPK) activation in a mouse model of polycystic ovary syndrome.
    Cell Biochem Funct 2018 Apr 20. Epub 2018 Apr 20.
    Department of Anatomy, School of medicine, Tehran University of Medical Sciences, Tehran, Iran.
    Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disorder in reproductive-aged women. Hormonal abnormality caused by steroidogenesis disturbances appears to be the main culprit of the clinical picture in PCOS. Vitamin D3 could regulate steroidogenesis in granulosa cells, but the mechanism of action of vitamin D3 on steroidogenesis remains unknown. Read More

    Up-Regulation of Long Noncoding RNA SRA Promotes Cell Growth, Inhibits Cell Apoptosis, and Induces Secretion of Estradiol and Progesterone in Ovarian Granular Cells of Mice.
    Med Sci Monit 2018 Apr 20;24:2384-2390. Epub 2018 Apr 20.
    Department of Obstetrics and Gynecology, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, China (mainland).
    BACKGROUND Increasing evidence indicates that long noncoding RNAs (LncRNAs) play a key role in multiple pathological processes. It has been shown that LncRNA steroid receptor RNA activator (SRA) is elevated in peripheral blood of patients with polycystic ovary syndrome (PCOS). The aim of this study was to assess the effect of elevated LncRNA SRA on ovarian granular cells of mice in vitro. Read More

    Maternal factors associated with offspring polycystic ovarian syndrome.
    BJOG 2018 Apr 19. Epub 2018 Apr 19.
    University of North Carolina, Chapel Hill, NC, USA.
    In this Swedish national registry-based cohort study Valgeirsdottir et al. sought to determine the association between 1) in-utero exposures and 2) birth indices and the subsequent development of polycystic ovarian syndrome (PCOS) after age 15. To do this, they selected 681,123 girls, whose birth was recorded in the Swedish birth registry between 1982 and 1995. Read More

    Genetic Variants Associated with Hyperandrogenemia in PCOS Pathophysiology.
    Genet Res Int 2018 18;2018:7624932. Epub 2018 Feb 18.
    Department of Molecular Endocrinology, National Institute for Research in Reproductive Health, J.M. Street, Parel, Mumbai 400012, India.
    Polycystic ovary syndrome is a multifactorial endocrine disorder whose pathophysiology baffles many researchers till today. This syndrome is typically characterized by anovulatory cycles and infertility, altered gonadotropin levels, obesity, and bulky multifollicular ovaries on ultrasound. Hyperandrogenism and insulin resistance are hallmark features of its complex pathophysiology. Read More

    Obesity and Outcome of Assisted Reproduction in Patients With Polycystic Ovary Syndrome.
    Front Endocrinol (Lausanne) 2018 4;9:149. Epub 2018 Apr 4.
    Second Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece.
    Assisted reproduction, including fertilization and intracytoplasmic sperm injection, is increasingly being used for the management of infertility in patients with polycystic ovary syndrome (PCOS). However, there are limited data regarding the association between obesity and the outcome of assisted reproduction in this specific population as well as on the effects of weight loss. The aim of the present review is to summarize the existing evidence on the association between obesity and the outcome of assisted reproduction in patients with PCOS. Read More

    Apa-I polymorphism in VDR gene is related to metabolic syndrome in polycystic ovary syndrome: a cross-sectional study.
    Reprod Biol Endocrinol 2018 Apr 18;16(1):38. Epub 2018 Apr 18.
    Division of Endocrinology, Gynecological Endocrinology Unit, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos, 2350, Porto Alegre, RS, 90035-003, Brazil.
    Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder determined by polygenic traits as well as environmental factors. Lower vitamin D levels have been detected in PCOS women and related to hormone and metabolic disturbances. Vitamin D acts in tissues through the vitamin D receptor (VDR). Read More

    Maternal polycystic ovarian syndrome and early offspring development.
    Hum Reprod 2018 Apr 13. Epub 2018 Apr 13.
    Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6710B Rockledge Drive, Bethesda, MD 20852, USA.
    Study Question: Is maternal polycystic ovarian syndrome (PCOS) associated with developmental delays in offspring?

    Summary Answer: Offspring of mothers with PCOS were at higher risk of failure on the Ages and Stages Questionnaire (ASQ).

    What Is Known Already: There is growing evidence that offspring of mothers with PCOS may be at higher risk for developmental disorders due to potential exposure to hyperandrogenism and insulin resistance. Few studies exist regarding maternal PCOS and early childhood development in the USA. Read More

    What is the optimal condition for fertilization of IVM oocytes?
    Reprod Med Biol 2013 Jan 10;12(1):15-20. Epub 2012 Aug 10.
    Department of Animal ScienceOkayama UniversityTsushima-Naka, Kita-Ku700-8530OkayamaJapan.
    Application of in vitro maturation (IVM) is recently increasing for human infertility, especially to rescue patients of polycystic ovarian syndrome and ovarian hyperstimulation syndrome. To increase the application of IVM oocytes for embryo production and the efficiency of successful production of babies using IVM oocytes, quality control of oocytes and achievement of fertilization in the most suitable condition may be very important. In this paper, suitable conditions for fertilization of IVM oocytes will be discussed with recent knowledge about IVM and in vitro fertilization of oocytes in domestic animals. Read More

    Effects of Probiotic Supplementation on Hormonal Profiles, Biomarkers of Inflammation and Oxidative Stress in Women With Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Arch Iran Med 2018 Jan 1;21(1):1-7. Epub 2018 Jan 1.
    Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.
    Background: To the best of our knowledge, data on effects of probiotic administration on hormonal profiles, biomarkers of inflammation and oxidative stress in women with polycystic ovary syndrome (PCOS) are scarce. This investigation was conducted to assess the effects of probiotic supplementation on hormonal profiles, biomarkers of inflammation and oxidative stress in women with PCOS.

    Methods: This randomized, double-blind, placebo-controlled trial was conducted on 60 women with PCOS, aged 18-40 years old. Read More

    Identification of Potential Biomarkers for Urine Metabolomics of Polycystic Ovary Syndrome Based on Gas Chromatography-Mass Spectrometry.
    Chin Med J (Engl) 2018 Apr;131(8):945-949
    Department of Obstetrics and Gynecology, Maternal and Child Health Hospital of Hunan Province, Changsha, Hunan 410008, China.
    Background: Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder, and it's diagnosis is difficult. The aim of this study was to investigate the metabolic profiles of PCOS patients by analyzing urine samples and identify useful biomarkers for diagnosis of PCOS.

    Methods: This study was carried out in the Department of Obstetrics and Gynecology of the Maternal and Child Health Hospital of Hunan Province from December 2014 to July 2016. Read More

    Reproductive health, obesity, and cardiometabolic risk factors among Samoan women.
    Am J Hum Biol 2018 Apr 16:e23106. Epub 2018 Apr 16.
    Department of Epidemiology and International Health Institute, Brown University School of Public Health, Providence, Rhode Island 02912.
    Objectives: Obesity leads to deleterious effects on not only cardiovascular health but also on the reproductive health of women. We estimate the prevalence of menstrual irregularity and of polycystic ovarian syndrome (PCOS) in Samoan women, among whom obesity prevalence is extremely high. We explore the association of these reproductive health conditions with adiposity, cardiometabolic risk factors, and androgen levels. Read More

    Healthy eating index in women with polycystic ovary syndrome: A case-control study.
    Int J Reprod Biomed (Yazd) 2017 Sep;15(9):575-582
    Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology, Research Institute Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Background: Despite many effort to identify and control the factors involved in polycystic ovary syndrome (PCOS), there are no available reports indicating the association of healthy eating index (HEI) and PCOS.

    Objective: The present study has been conducted to examine the relationship between HEI and PCOS.

    Materials And Methods: In this case-control study, the study population comprised 297 women aged 20-40 yr referred to Baqiyatallah Hospital Clinics, Tehran, Iran in two groups: case group (n=99) and control group (n=198). Read More

    Comparison of the effects of Ginger extract with clomiphene citrate on sex hormones in rats with polycystic ovarian syndrome.
    Int J Reprod Biomed (Yazd) 2017 Sep;15(9):561-568
    Student Research Committee, Jahrom University of Medical Sciences, Jahrom, Iran.
    Background: Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder in women which affect fertility. Clomiphene citrate is used as first-line treatment for this disorder, which is associated with some complications and therapeutic resistance.

    Objective: In this research, we compare the effectiveness of ginger with clomiphene on sexual hormones such as Luteinizing hormone (LH), Follicle-stimulating hormone (FSH), estrogen and progesterone in order to treat PCOS effectively with fewer side effects. Read More

    Facilitating and inhibiting factors related to treatment adherence in women with polycystic ovary syndrome: A qualitative study.
    Int J Reprod Biomed (Yazd) 2017 Sep;15(9):553-560
    Social Determinants of Health Research Center, Yasuj University of Medical Sciences, Yasuj, Iran.
    Background: Adherence issues in polycystic ovary syndrome (PCOS) patients have not been examined thoroughly. Patients report prolonged periods of treatment and side effects of the drug as the most common reason for withdrawal from treatment. To improve the effective management of PCOS patients, it is fundamental to understand facilitating and inhibiting factors to treatment adherence. Read More

    A Comparative Study on Quantitative Assessment of Blood Flow and Vascularization in Polycystic Ovary Syndrome Patients and Normal Women Using Three-Dimensional Power Doppler Ultrasonography.
    J Obstet Gynaecol India 2018 Apr 21;68(2):136-141. Epub 2017 Dec 21.
    1Department of Obstetrics and Gynecology, Adesh Institute of Medical Sciences and Research, Bathinda, Punjab India.
    Purpose Of The Study: To compare the quantitative assessment of blood flow and vascularization of ovaries in polycystic ovary syndrome patients and normal women using three-dimensional power Doppler ultrasonography.

    Methods: This cross-sectional quantitative study was conducted on women of reproductive age group (15-45 years) attending Gynaecology OPD AIMSR, Bathinda, Punjab. Thirty women were enrolled in polycystic ovarian syndrome (PCOS) group and 30 healthy women in control group. Read More

    Role of AMH as Diagnostic Tool for Polycystic Ovarian Syndrome.
    J Obstet Gynaecol India 2018 Apr 15;68(2):117-122. Epub 2017 Nov 15.
    1Department of Obstetric and Gynecology, PGIMER and Dr RML Hospital, New Delhi, 110001 India.
    Background: To evaluate role of AMH as a diagnostic tool for PCOS.

    Methods: This was a prospective case-control study on women attending Gynae OPD of Dr RML Hospital, New Delhi, from 1 November 2015 to 31 March 2017. Study comprised of 45 women with PCOS, diagnosed using Rotterdam criteria and 45 women as controls. Read More

    Reproductive Health Care Priorities and Barriers to Effective Care for Lesbian, Gay, Bisexual, Transgender, Queer People Assigned Female at Birth: A Qualitative Study.
    Womens Health Issues 2018 Apr 13. Epub 2018 Apr 13.
    Advancing New Standards in Reproductive Health, Department of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Francisco, Oakland, California.
    Background: Little research documents the self-identified reproductive health priorities and health care experiences of lesbian, gay, bisexual, transgender, queer (LGBTQ)-identified individuals who may be in need of services.

    Methods: We conducted in-depth interviews with a diverse sample of 39 female-assigned-at-birth individuals (ages 18-44) who also identified as lesbian, bisexual, queer, and/or genderqueer, or transmasculine. Interviews were primarily conducted in person in the Bay Area of California, and Baltimore, Maryland, with 11 conducted remotely with participants in other U. Read More

    Interpretation of serum gonadotropin levels in hyperprolactinemia.
    Neuroendocrinology 2018 Apr 16. Epub 2018 Apr 16.

    Background/Aims: Hyperprolactinemia is a common cause of amenorrhea due to hypogonadotropic hypogonadism. Prolactin is hypothesized to impede the reproductive axis through an inhibitory action at the hypothalamus. However, limited data exists to aid the interpretation of serum gonadotropins in the context of hyperprolactinemia. Read More

    Hyperhomocysteinemia and hyperandrogenemia share PCSK9-LDLR pathway to disrupt lipid homeostasis in PCOS.
    Biochem Biophys Res Commun 2018 Apr 13. Epub 2018 Apr 13.
    Reproductive Biology Research, CSIR-Indian Institute of Chemical Biology, Jadavpur, Kolkata, 700032, WB, India. Electronic address:
    Women with polycystic ovary syndrome (PCOS) are at increased risk of cardiovascular diseases (CVD); however, the independent role of PCOS in the incident CVD remains unknown. There are reports that hyperhomocysteinemia (HHcy), a potential cause of CVD, is frequently associated with PCOS. The present study investigates the independent attributes of hyperandrogenemia (HA), the integral associate of PCOS, and HHcy in causing atherogenic dyslipidemia. Read More

    Subclinical hypothyroidism is not a risk factor for polycystic ovary syndrome in obese women of reproductive age.
    Gynecol Endocrinol 2018 Apr 16:1-5. Epub 2018 Apr 16.
    a Department of Endocrinology , Drum Tower Hospital Affiliated to Nanjing University Medical School , Nanjing , China.
    Obese women are at high risk for polycystic ovary syndrome (PCOS). Subclinical hypothyroidism (SCH) has been associated with weight gain, insulin resistance and impaired fertility, which are also factors involved in PCOS. However, there is limited information regarding the influence of SCH on the presence of PCOS. Read More

    Serum chemerin level in women with PCOS and its relation with the risk of spontaneous abortion.
    Gynecol Endocrinol 2018 Apr 16:1-4. Epub 2018 Apr 16.
    a Xiangyang Central Hospital, The Affiliated Hospital of Hubei University of Arts and Science , Xiangyang , China.
    Background And Aim: Insulin resistance (IR) was recognized as a risk factor for the occurrence of abortion in patients with polycystic ovary syndrome (PCOS). Chemerin was an adipokine which could induce IR and associated with reproductive process closely. However, few studies have inquired the relativity between chemerin and the occurrence of abortion in patients with PCOS. Read More

    High estrogen exposure may not be detrimental on endometrial receptivity in women with PCOS.
    Gynecol Endocrinol 2018 Apr 14:1-6. Epub 2018 Apr 14.
    a Department of Obstetrics and Gynecology , Zeynep Kamil Women and Children's Health Training and Research Hospital , İstanbul , Turkey.
    The study aimed to assess the effect of high estrogen exposure and coasting on cycle outcome in women at risk for developing ovarian hyperstimulation syndrome (OHSS). Retrospective case-control study was conducted to figure out the outcomes of GnRH antagonist cycles in which women were at risk to develop OHSS. Women who underwent coasting (n = 100) were compared with a control group of women who did not undergo coasting (n = 287). Read More

    Effect of 12-month treatment with metformin and/or oral contraceptives on health-related quality of life in polycystic ovary syndrome.
    Gynecol Endocrinol 2018 Apr 16:1-5. Epub 2018 Apr 16.
    a Department of Endocrinology and Metabolism , Odense University Hospital , Odense C , Denmark.
    Health-related quality of life (HRQoL) is impaired in polycystic ovary syndrome (PCOS), but the effect of treatment with metformin (M) and/or oral contraceptives (OCP) is undetermined. To assess changes in HRQoL during 12-month randomized treatment with M, OCP or M + OCP in PCOS. Ninety women with PCOS were randomized to treatment with M, OCP or M + OCP. Read More

    Elevated levels of the circulatory ischemia-modified albumin in patients with polycystic ovary syndrome: a meta-analysis.
    Gynecol Endocrinol 2018 Apr 14:1-7. Epub 2018 Apr 14.
    c Biomedical Informatics Center (BMIC), National Institute of Nutrition-Indian Council of Medical Research , Hyderabad , India.
    Oxidative stress (OS) has been reported to be associated with the pathogenesis of polycystic ovary syndrome (PCOS). Ischemia-modified albumin (IMA) levels in the circulation have been recently studied as a novel marker of OS. The studies in the literature on IMA levels in PCOS are inconsistent. Read More

    Classic, Provocative and/or Influential: A Twin Study Sampler/Twin Research Reviews: Twin Pregnancies With and Without Polycystic Ovary Syndrome; Ectopic Twin Pregnancy; Sex Differences in Cognition; Maternal Cardiac Hemodynamics/Newsworthy: President Obama's Portrait Artist; Winkelvoss Twins Update; Triplet Models; 'Meet Your Twin'.
    Twin Res Hum Genet 2018 Apr 15:1-6. Epub 2018 Apr 15.
    Department of Psychology,California State University,Fullerton,CA,USA.
    Selected twin research papers that are classic, provocative, and/or influential are surveyed. Many papers meet these criteria, so those chosen reflect the opinion of the author. Reviews of recent research on twin pregnancies with and without polycystic ovary syndrome, ectopic pregnancy, sex differences in cognition and maternal cardiac hemodynamics follow. Read More

    Associations between vitamin D levels and polycystic ovary syndrome (PCOS) phenotypes.
    Minerva Endocrinol 2018 Apr 12. Epub 2018 Apr 12.
    Department of Obstetrics and Gynecology, Section of Reproductive Endocrinology and Infertility, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
    Background: Studies comparing serum 25-hydroxyvitamin D concentrations in women with and without PCOS have produced inconsistent results. Additionally, no previous studies have evaluated associations between vitamin D and specific PCOS phenotypes.

    Methods: This case-control study was conducted among women undergoing intrauterine insemination. Read More

    Performance of the 2015 US Preventive Services Task Force Screening Criteria for Prediabetes and Undiagnosed Diabetes.
    J Gen Intern Med 2018 Apr 12. Epub 2018 Apr 12.
    Division of General Internal Medicine and Geriatrics, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
    Background: In 2015, The US Preventive Services Task Force (USPSTF) recommended screening for prediabetes and undiagnosed diabetes (collectively called dysglycemia) among adults aged 40-70 years with overweight or obesity. The recommendation suggests that clinicians consider screening earlier in people who have other diabetes risk factors.

    Objective: To compare the performance of limited and expanded screening criteria recommended by the USPSTF for detecting dysglycemia among US adults. Read More

    The effects of synbiotic supplementation on hormonal status, biomarkers of inflammation and oxidative stress in subjects with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial.
    BMC Endocr Disord 2018 Apr 12;18(1):21. Epub 2018 Apr 12.
    Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, IR, Iran.
    Background: To our knowledge, no reports are available indicating the effects of synbiotic supplementation on hormonal status, biomarkers of inflammation and oxidative stress in subjects with polycystic ovary syndrome (PCOS). This research was done to assess the effects of synbiotic supplementation on hormonal status, biomarkers of inflammation and oxidative stress in subjects with PCOS.

    Methods: This randomized double-blind, placebo-controlled trial was conducted on 60 subjects diagnosed with PCOS according to the Rotterdam criteria. Read More

    Polycystic ovary syndrome is associated with adverse mental health and neurodevelopmental outcomes.
    J Clin Endocrinol Metab 2018 Apr 10. Epub 2018 Apr 10.
    Institute of Primary Care and Public Health, School of Medicine, Cardiff University, Cardiff, United Kingdom.
    Context: Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism and subfertility but the effects on mental health and child neurodevelopment are unclear.

    Objectives: To determine if (i) there is an association between PCOS and psychiatric outcomes, and (ii) whether rates of autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) are higher in children of mothers with PCOS.

    Design: Data were extracted from the Clinical Practice Research Datalink. Read More

    Downregulation of serum long noncoding RNA GAS5 may contribute to insulin resistance in PCOS patients.
    Gynecol Endocrinol 2018 Apr 12:1-5. Epub 2018 Apr 12.
    a Department of Gynecology & Obstetrics , Sun Yat-sen Memorial Hospital of Sun Yat-sen University , Guangzhou , China.
    Polycystic ovary syndrome (PCOS) is a common endocrine disease that affects reproductive-aged women and mostly characterized by insulin resistance (IR). The underlying mechanism remains unknown. Long noncoding RNAs (lncRNAs) have been demonstrated to be involved in various levels of biological regulation process of cell development, metabolism, and differentiation. Read More

    Pregnancy complications in infertile patients with polycystic ovary syndrome: updated evidences.
    Minerva Ginecol 2018 Apr 11. Epub 2018 Apr 11.
    Department of Obstetrics and Gynecology, AUSL-IRCCS of Reggio Emilia, Reggio Emilia, Italy.
    Polycystic ovary syndrome (PCOS) is a common female disorder with a pathogenesis still today not completely known. To the present, PCOS is considered more than just a reproductive disorder since several metabolic consequences that could affect women's health during different stages of reproductive and post-reproductive life were reported. The aim of the current review was to evaluate present evidence-based data regarding the pregnancy complications in infertile patients with PCOS. Read More

    GnRH dysregulation in polycystic ovarian syndrome (PCOS) is a manifestation of an altered neurotransmitter profile.
    Reprod Biol Endocrinol 2018 Apr 11;16(1):37. Epub 2018 Apr 11.
    Reproductive-Neuro-Endocrinology Lab, Department of Biochemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat, India.
    Background: GnRH is the master molecule of reproduction that is influenced by several intrinsic and extrinsic factors such as neurotransmitters and neuropeptides. Any alteration in these regulatory loops may result in reproductive-endocrine dysfunction such as the polycystic ovarian syndrome (PCOS). Although low dopaminergic tone has been associated with PCOS, the role of neurotransmitters in PCOS remains unknown. Read More

    An Overview of Novel Dietary Supplements and Food Ingredients in Patients with Metabolic Syndrome and Non-Alcoholic Fatty Liver Disease.
    Molecules 2018 Apr 11;23(4). Epub 2018 Apr 11.
    Post Graduate Program in Health and Development in the Central-West Region, Federal University of Mato Grosso do Sul, Campo Grande 79070900, Brazil.
    Metabolic syndrome (MetS) is characterized by interconnected factors related to metabolic disturbances, and is directly related to the occurrence of some diseases such as cardiovascular diseases and type 2 diabetes. MetS is described as one or both of insulin resistance and visceral adiposity, considered the initial causes of abnormalities that include hyperglycemia, elevated blood pressure, dyslipidemia, elevated inflammatory markers, and prothrombotic state, as well as polycystic ovarian syndrome in women. Other than in MetS, visceral adiposity and the pro-inflammatory state are also key in the development of non-alcoholic fatty liver disease (NAFLD), which is the most prevalent chronic liver disease in modern society. Read More

    Increased risk of polycystic ovary syndrome (PCOS) associated with CC genotype of miR-146a gene variation.
    Gynecol Endocrinol 2018 Apr 11:1-5. Epub 2018 Apr 11.
    b Cellular and Molecular Research Center, Basic Health Sciences Institute , Shahrekord University of Medical Sciences , Shahrekord , Iran.
    Polycystic ovary syndrome (PCOS) is an endocrinopathy in reproductive-age women believed to be affected by several genetics and environmental factors or both. Different miRNAs are one of such genetic factors that their associations with PCOS have been implicated. For instance, miR-146a that is well known for strongly regulating the immune response and inflammation was upregulated in serum plasma, follicular fluid and granulosa cells of PCOS patients. Read More

    Survey of antiobesity drug prescribing for obese children and young people in UK primary care.
    BMJ Paediatr Open 2017 25;1(1):e000104. Epub 2017 Oct 25.
    Centre for Paediatric Pharmacy Research, UCL School of Pharmacy, London, UK.
    Objectives: Antiobesity drug (AOD) prescribing in children and young people (CYP) in primary care is rising with high rates of discontinuation. Little is known about prescribing in this group in terms of patient demographics and comorbidities, reasons for initiation and discontinuation, or adherence to national guidelines.

    Design: Questionnaire survey to general practitioners (GPs) identified using a nationally representative primary care database covering 6% of UK population. Read More

    The Role of Follicular Fluid Thiol/Disulphide Homeostasis in Polycystic Ovary Syndrome.
    Balkan Med J 2018 04 4. Epub 2018 Apr 4.
    Yildirim Beyazit University, Faculty of Medicine, Department of Biochemistry, Ankara, Turkey
    Background: Oxidative stress is suggested as a potential triggering factor in the etiopathogenesis of Polycystic ovary syndrome related infertility. Thiol/disulphide homeostasis, a recently oxidative stress marker, is one of the antioxidant mechanism in human which have critical roles in folliculogenesis and ovulation.

    Aims: The aim of our study is to investigate follicular fluid thiol/disulphide homeostasis in the etiopathogenesis of Polycystic ovary syndrome and to determine its' association with in vitro fertilization outcome. Read More

    Pregnancy outcomes of PCOS overweight/obese patients after controlled ovarian stimulation with the GnRH antagonist protocol and frozen embryo transfer.
    Reprod Biol Endocrinol 2018 Apr 10;16(1):36. Epub 2018 Apr 10.
    Key Laboratory for Reproduction and Genetics of Guangdong Higher Education Institutes, Key Laboratory for Major Obstetric Diseases of Guangdong Province, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, People's Republic of China.
    Background: Overweight/obese women with polycystic ovary syndrome (PCOS) are at increased risk of subfertility and complications of pregnancy, compared with normal-weight women. To implement controlled ovarian hyperstimulation (COH), the improved efficacy of the gonadotrophin-releasing hormone antagonist (GnRH-ant) protocol has been demonstrated, as well as frozen embryo transfer (FET).

    Objective: This retrospective study evaluated the pregnancy outcomes after combined GnRH-ant protocol and FET in overweight/obese women with PCOS, with reference to that of normal-weight women with PCOS. Read More

    Effects of apoC1 genotypes on the hormonal levels, metabolic profile and PAF-AH activity in Chinese women with polycystic ovary syndrome.
    Lipids Health Dis 2018 Apr 10;17(1):77. Epub 2018 Apr 10.
    Laboratory of Genetic Disease and Perinatal Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, 610041, People's Republic of China.
    Background: Elevated serum levels of apolipoprotein (apo) C1 may be an early protein marker of metabolic abnormality in women with polycystic ovary syndrome (PCOS). It is not clear, however, whether there are any relationships between the apoC1 rs4420638A/G and -317deletion (H1)/insertion (H2) polymorphisms and PCOS. We investigated the relationship between these two variants and the risk of PCOS, evaluated the genotypic effects on clinical, hormonal and metabolic indexes and plasma platelet-activating factor acetylhydrolase (PAF-AH) activity, and defined the association of apoC1 gene variants with apoE ε2/ε3/ε4 polymorphisms. Read More

    Impact of stress on female reproductive health disorders: Possible beneficial effects of shatavari (Asparagus racemosus).
    Biomed Pharmacother 2018 Apr 7;103:46-49. Epub 2018 Apr 7.
    Cell Physiology Laboratory, Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi, 221005, U.P., India. Electronic address:
    Stress is deeply rooted in the society and women are frequently exposed to psychological, physical and physiological stressors. Psychological stress disturbs reproductive health by inducing generation of reactive oxygen species (ROS) and thereby oxidative stress (OS). The increased OS may affect physiology of ovary, oocyte quality and cause female reproductive health disorders. Read More

    Changes in ovarian reserve and ovarian blood flow in patients with polycystic ovary syndrome following laparoscopic ovarian drilling.
    Gynecol Endocrinol 2018 Apr 10:1-4. Epub 2018 Apr 10.
    a Department of Obstetrics and Gynecology, Faculty of Medicine , Menoufia University , Shebin El-Kom , Egypt.
    This prospective cohort study was conducted on 80 patients with clomiphene citrate (CC)-resistant polycystic ovary syndrome undergoing laparoscopic ovarian drilling (LOD). Pre- and post-LOD ovarian reserve parameters (anti-Mullerian hormone: AMH, ovarian volume: OV, and antral follicle count: AFC) and ovarian stromal blood flow indices (Vascularization index: VI, flow index: FI, and vascularization flow index: VFI) were measured to explore the effect of LOD and to find out the correlation between serum AMH and different clinical, hormonal, and ultrasonic variables. There was a highly significant reduction of the serum AMH (p < . Read More

    The monocyte counts to HDL cholesterol ratio in obese and lean patients with polycystic ovary syndrome.
    Reprod Biol Endocrinol 2018 Apr 10;16(1):34. Epub 2018 Apr 10.
    Department of Obstetrics and Gynecology, School of Medicine, Balıkesir University Faculty of Medicine, Cagis Yerleskesi, Bigadic yolu 17. km, 10145, Balikesir, Turkey.
    Background: Women with polycystic ovary syndrome are more likely to suffer from obesity, insulin resistance, and chronic low-grade inflammation. In fact, the excessive activation of monocytes exacerbates oxidative stress and inflammation. However, high-density lipoprotein cholesterol neutralizes the pro-inflammatory and pro-oxidant effects of monocytes. Read More

    Effects of testosterone on PPARγ and P450arom expression in polycystic ovary syndrome patients and related mechanisms.
    Eur Rev Med Pharmacol Sci 2018 Mar;22(6):1549-1553
    Department of Obstetrics, Jinan Maternity and Child Care Hospital, Jinan, Shandong, China.
    Objective: Polycystic ovary syndrome (PCOS) causes ovulation disorder and infertility in female patients. This study recruited PCOS patients and adopted testosterone therapy to analyze its effect on expression of nuclear peroxisome proliferation activated receptor γ (PPARγ), and cytochrome P450 aromatase (P450arom) in ovary granular cells of patients.

    Patients And Methods: PCOS and non-PCOS patients were treated with testosterone at 1. Read More

    Lower Levels of Serum Adiponectin and the T Allele of rs1501299 of the Gene Are Protective against Polycystic Ovarian Syndrome in Jordan.
    Korean J Fam Med 2018 Mar 22;39(2):108-113. Epub 2018 Mar 22.
    Department of Physiology and Biochemistry, School of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
    Background: Polycystic ovary syndrome (PCOS) is a common reproductive disorder. Obesity, which is linked with lower adiponectin levels, increases a woman's risk of developing PCOS; however, the association between adiponectin and PCOS is controversial. Adiponectin levels could be affected by single nucleotide polymorphisms (SNPs) in the gene. Read More

    Eicosapentaenoic Acid Improves Polycystic Ovary Syndrome in Rats via Sterol Regulatory Element-Binding Protein 1 (SREBP-1)/Toll-Like Receptor 4 (TLR4) Pathway.
    Med Sci Monit 2018 Apr 8;24:2091-2097. Epub 2018 Apr 8.
    Reproductive Medicine Center, People's Hospital of Wuhan University, Wuhan, Hubei, China (mainland).
    BACKGROUND This study aimed to investigate the protective effect of eicosapentaenoic acid (EPA) on rats with polycystic ovary syndrome (PCOS). MATERIAL AND METHODS Rats with PCOS were intraperitoneally injected with different doses of EPA. Levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), and testosterone (T) were measured using corresponding kits. Read More

    Role of RAB5A in FSHR-mediated signal transduction in human granulosa cells.
    Reproduction 2018 Apr 6. Epub 2018 Apr 6.
    Y Du, Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200135, China, Shanghai, China
    Polycystic ovary syndrome, a common condition characterized by endocrine dysfunction, menstrual irregularity, anovulation, and polycystic ovaries, affects 5%-7% of reproductive-age women. RAB5B, which is identified by a genome-wide association study as a risk locus for this syndrome, encodes a small GTPase involved in control of receptor internalization and early endosome fusion. We found that RAB5A mRNA levels in luteinized granulosa cells of obese patients with polycystic ovary syndrome were lower than in those of obese women without the syndrome. Read More

    Endocr Pract 2018 Apr 6. Epub 2018 Apr 6.
    Center for Transgender Medicine and Surgery, Mount Sinai Health System and Icahn School of Medicine at Mount Sinai, New York, NY 10128 USA.
    Objectives: Polycystic ovarian syndrome (PCOS) is a complex condition which can include menstrual irregularity, metabolic derangement, and increased androgen levels. The mechanism of PCOS is unknown. Some suggest that excess production of androgens by the ovaries may cause or exacerbate the metabolic findings. Read More

    Potential genetic polymorphisms predicting polycystic ovary syndrome.
    Endocr Connect 2018 Apr 5. Epub 2018 Apr 5.
    S Fang, Hangzhou Fuyang Women and Children Hospital, Hangzhou, China.
    Polycystic ovary syndrome (PCOS) is a heterogenous endocrine disorder with typical symptoms of oligomenorrhoea, hyperandrogenism, hirsutism, obesity, insulin resistance and increased risk of type 2 diabetes mellitus. Extensive evidence indicates that PCOS is a genetic disease and numerous biochemical pathways have been linked with its pathogenesis. A number of genes from these pathways have been investigated, which include those involved with steroid hormone biosynthesis and metabolism, action of gonadotropin and gonadal hormones, folliculogenesis, obesity and energy regulation, insulin secretion and action and many others. Read More

    Polycystic ovary syndrome in Central Australia: Diagnosis and screening of cardiometabolic risk and emotional wellbeing
    Aust J Gen Pract 2018 04;4(4):227-232
    MBBS, FRANZCOG, MPH@TM, PhD, Senior Research Fellow, Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Melbourne, Vic.
    Background And Objectives: Polycystic ovary syndrome (PCOS) is a common condition that affects fertility, body image and emotional wellbeing in women, as well as significantly increasing a woman’s likelihood of developing type 2 diabetes mellitus (T2DM) and other cardiovascular disease risk factors. The objective of this study was to assess how management of PCOS in an Aboriginal primary care setting aligns with national standards for diagnosis and screening of cardiometabolic risk and emotional wellbeing.

    Method: We conducted a retrospective clinical audit of 63 women who had PCOS listed as a diagnosis in their clinical record. Read More

    Clinical, Hormonal, and Metabolic Parameters in Women with Subclinical Hypothyroidism and Polycystic Ovary Syndrome: A Cross-Sectional Study.
    J Womens Health (Larchmt) 2018 Apr 5. Epub 2018 Apr 5.
    4 Department of Obstetrics and Gynaecology, School of Medicine, Case Western Reserve University , Cleveland, Ohio.
    Background: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in reproductive age women, yet its clinical presentation shares similarities with several other endocrine disorders such as thyroid disease. Hence, the objective of this study was to further evaluate this association by investigating the clinical, hormonal, and metabolic parameters between subclinical hypothyroidism (SCH) and PCOS.

    Methods: This is a cross-sectional study conducted in a tertiary care clinic at Cleveland, Ohio, USA. Read More

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