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    15485 results match your criteria Polycystic Ovarian Syndrome

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    Stable ischemic heart disease in women: current perspectives.
    Int J Womens Health 2017 27;9:701-709. Epub 2017 Sep 27.
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
    Cardiovascular disease is the leading cause of death in women accounting for 1 in every 4 female deaths. Pathophysiology of ischemic heart disease in women includes epicardial coronary artery, endothelial dysfunction, coronary vasospasm, plaque erosion and spontaneous coronary artery dissection. Angina is the most common presentation of stable ischemic heart disease (SIHD) in women. Read More

    Metabolic pathways of oleic and palmitic acid are intensified in PCOS patients with normal androgen levels.
    Prostaglandins Leukot Essent Fatty Acids 2017 Nov 8;126:105-111. Epub 2017 Sep 8.
    Department of Biochemistry and Human Nutrition, Pomeranian Medical University in Szczecin, Poland.
    Context: The aetiology and pathogenesis polycystic ovary syndrome (PCOS) remain uncertain and thus the relative studies are still crucial.

    Objective: Our aim was to analyse the fatty acids profiles of the main phospholipids species in serum from women with PCOS classified into phenotypes, and to diagnose women more susceptible to the occurrence of inflammatory state.

    Design: PCOS screening tests were performed in The Clinic of Gynecology and Urogynecology of Pomeranian Medical University in the 2014-2015 years. Read More

    Impaired branched-chain amino acid metabolism may underlie the nonalcoholic fatty liver disease-like pathology of neonatal testosterone-treated female rats.
    Sci Rep 2017 Oct 13;7(1):13167. Epub 2017 Oct 13.
    Laboratorio de Ginecologia Estrutural e Molecular (LIM 58), Disciplina de Ginecologia, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, 01246903, Brazil.
    Polycystic ovary syndrome (PCOS) is frequently associated with non-alcoholic fatty liver disease (NAFLD), but the mechanisms involved in the development of NAFLD in PCOS are not well known. We investigated histological changes and metabolomic profile in the liver of rat models of PCOS phenotype induced by testosterone or estradiol. Two-day old female rats received sc injections of 1. Read More

    Autophagy is activated in the ovarian tissue of polycystic ovary syndrome.
    Reproduction 2017 Oct 13. Epub 2017 Oct 13.
    Q Yang, Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
    The importance of autophagy in polycystic ovary syndrome (PCOS)-related metabolic disorders is increasingly being recognized, but few studies have investigated the role of autophagy in PCOS. Here, transmission electron microscopy demonstrated that autophagy was enhanced in the ovarian tissue from both humans and rats with PCOS. Consistent with this, ovarian granulosa cells from PCOS rats showed increases in the autophagy marker protein light chain 3B (LC3B), whereas levels of the autophagy substrate SQSTM1/p62 were decreased. Read More

    Polymorphisms in the TFAM and PGC1-α genes and their association with polycystic ovary syndrome among South Indian women.
    Gene 2017 Oct 10. Epub 2017 Oct 10.
    Department of Biochemistry, Osmania University, Hyderabad 500 007, India. Electronic address:
    We investigated the link between polymorphisms in genes involved in mitochondrial biogenesis, mitochondrial transcription factor A (TFAM) and Peroxisome proliferator activated receptor gamma coactivator-1 alpha (PGC-1α) and further studied the role of these genes on the pathophysiology of polycystic ovary syndrome (PCOS). This case-control study was carried out in 118 PCOS cases and 110 controls. In the present study we genotyped three polymorphisms of PGC1-α gene (rs8192678-Gly482Ser, rs13131226 and rs2970856) and polymorphism of TFAM gene (rs1937-+35G/C) by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. Read More

    Functional characterization of microRNA-27a-3p expression in human polycystic ovary syndrome.
    Endocrinology 2017 Sep 29. Epub 2017 Sep 29.
    State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing 100193, China.
    The goal of this study was to characterize the function of microRNA-27a-3p (miR-27a-3p) in polycystic ovary syndrome (PCOS). MiR-27a-3p expression was analyzed in excised granulosa cells (GCs) from 21 PCOS and 12 normal patients undergoing IVF cycle treatments, and in 17 non-treated cuneiform ovarian resection PCOS samples and 13 control ovarian samples-from non-PCOS patients. We found that the expression of miR-27a-3p was significantly increased in both excised GCs and the ovaries of PCOS patients compared to the controls. Read More

    Ovarian Follicular Theca Cell Recruitment, Differentiation and Impact on Fertility: 2017 Update.
    Endocr Rev 2017 Oct 5. Epub 2017 Oct 5.
    Department of Obstetrics, Gynecology and Reproductive Medicine, Magee-Women's Research Institute, Pittsburgh, PA 15213.
    The major goal of this review is to summarize recent exciting findings that have been published within the past 10 years that, to our knowledge, have not been presented in detail in previous reviews and that may impact altered follicular development in polycystic ovarian syndrome (PCOS) and premature ovarian failure (POF) in women. Specifically, we will cover 1) mouse models that have led to discovery of the derivation of two precursor populations of theca cells in the embryonic gonad, 2) the key roles of the oocyte-derived factor GDF9 on the hedgehog (HH) signaling pathway and theca cell functions and 3) the impact of the HH pathway on both the specification of theca endocrine cells and theca fibroblast and smooth muscle cells in developing follicles. We will also discuss 1) other signaling pathways that impact the differentiation of theca cells, not only LH but also INSL3, BMPs, the circadian clock genes, androgens and estrogens and 2) theca associated vascular, immune and fibroblast cells, as well as the cytokines and matrix factors that play key roles in follicle growth. Read More

    Correlation of Vitamin D with metabolic parameters in polycystic ovarian syndrome.
    J Family Med Prim Care 2017 Jan-Mar;6(1):115-119
    Department of Endocrinology, Army Hospital (R&R), New Delhi, India.
    Background: Polycystic ovarian syndrome (PCOS) and hypovitaminosis D are the two most common endocrine disorders in young women leading to many adverse metabolic consequences. We evaluated the correlation of 25-hydroxy Vitamin D (25OHD) with metabolic parameters and insulin resistance in PCOS.

    Materials And Methods: We included 100 PCOS patients (age 18-40 years, duration >6 months) serially, in this cross-sectional study. Read More

    Expression of the genes for peroxisome proliferator-activated receptor-γ, cyclooxygenase-2, and proinflammatory cytokines in granulosa cells from women with polycystic ovary syndrome.
    Clin Exp Reprod Med 2017 Sep 26;44(3):146-151. Epub 2017 Sep 26.
    Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.
    Objective: To identify differences in the expression of the genes for peroxisome proliferator-activated receptor (PPAR)-γ, cyclooxygenase (COX)-2, and the proinflammatory cytokines interleukin (IL)-6 and tumor necrosis factor (TNF)-α in granulosa cells (GCs) from polycystic ovary syndrome (PCOS) patients and controls undergoing controlled ovarian stimulation.

    Methods: Nine patients with PCOS and six controls were enrolled in this study. On the day of oocyte retrieval, GCs were collected from pooled follicular fluid. Read More

    Cohort profile for the MASTERMIND study: using the Clinical Practice Research Datalink (CPRD) to investigate stratification of response to treatment in patients with type 2 diabetes.
    BMJ Open 2017 Oct 12;7(10):e017989. Epub 2017 Oct 12.
    NIHR Exeter Clinical Research Facility, University of Exeter Medical School, Exeter, UK.
    Purpose: This is a retrospective cohort study using observational data from anonymised primary care records. We identify and extract all patients with type 2 diabetes and associated clinical data from the Clinical Practice Research Datalink (CPRD) to inform models of disease progression and stratification of treatment.

    Participants: Data were extracted from CPRD on 8 August 2016. Read More

    Presence of polycystic ovary syndrome is associated with longer anogenital distance in adult Mediterranean women.
    Hum Reprod 2017 Aug 30:1-9. Epub 2017 Aug 30.
    Institute for Biomedical Research of Murcia, IMIB-Arrixaca, 30120 El Palmar (Murcia), Spain.
    Study Question: Is polycystic ovary syndrome (PCOS) associated with anogenital distance (AGD), a biomarker of fetal androgen exposure, in adult Mediterranean women?

    Summary Answer: Longer AGD is associated with PCOS in adult Mediterranean women.

    What Is Known Already: AGD is a biomarker of prenatal androgen milieu. Human observational studies have reported that associations between AGD and reproductive parameters in both sexes. Read More

    Polycystic Ovarian Syndrome (PCOS): long-term metabolic consequences.
    Metabolism 2017 Oct 9. Epub 2017 Oct 9.
    Department of Obstetrics and Gynecology, Texas Tech University Health Sciences Center School of Medicine, Amarillo, Texas, USA.
    Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women during their reproductive ages, associated with a plethora of cardiometabolic consequences, with obesity, insulin resistance and hyperandrogenemia playing a major role in the degree of such manifestations. These consequences include increased risk of glucose intolerance and diabetes mellitus (both type 2 and gestational), atherogenic dyslipidemia, systemic inflammation, non-alcoholic fatty liver disease, hypertension and coagulation disorders. Whether this cluster of metabolic abnormalities is also translated in increased cardiovascular disease (CVD) morbidity and mortality in later life, remains to be established. Read More

    Ketogenic diet in endocrine disorders: Current perspectives.
    J Postgrad Med 2017 Oct-Dec;63(4):242-251
    Department of Medicine, Division of Endocrinology, Pandit Bhagwat Dayal Sharma Postgraduate Institute of Medical Sciences, Rohtak, Haryana, India.
    Ketogenic diet (KD) is a high-fat, adequate-protein, and low-carbohydrate diet that leads to nutritional ketosis, long known for antiepileptic effects and has been used therapeutically to treat refractory epilepsy. This review attempts to summarize the evidence and clinical application of KD in diabetes, obesity, and other endocrine disorders. KD is usually animal protein based. Read More

    Beneficial effects of Heqi san on rat model of polycystic ovary syndrome through the PI3K/AKT pathway.
    Daru 2017 Oct 11;25(1):21. Epub 2017 Oct 11.
    Department of Endocrine, Traditional Chinese Medicine Hospital of Shenzhen, Shenzhen, Guangdong, 518033, China.
    Background: Heqi San, a traditional Chinese medicine (TCM) has been reported to regulate hormone levels in patients with metabolic disease, suggesting a potential clinical application. In the current study, we aimed to elucidate the effect of Heqi San on rat model of polycystic ovary syndrome (PCOS).

    Method: PCOS model was established in female SD rats. Read More

    Xiao-Yao-San, a Chinese Medicine Formula, Ameliorates Chronic Unpredictable Mild Stress Induced Polycystic Ovary in Rat.
    Front Physiol 2017 22;8:729. Epub 2017 Sep 22.
    Department of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, Peking UniversityBeijing, China.
    Chronic stress induces endocrine disturbance, which contributes to the development of polycystic ovary syndrome (PCOS), a condition that remains a challenge for clinicians to cope with. The present study investigated the effect of Xiao-Yao-San (XYS), a traditional Chinese medicine formula used for treatment of gynecological disease, on the chronic stress-induced polycystic ovary and its underlying mechanism. Female Sprague-Dwaley rats underwent a 3 weeks chronic unpredictable mild stress (CUMS) procedure to establish the PCOS model, followed by 4 weeks treatment with XYS (0. Read More

    The effect of atorvastatin on pancreatic beta cell requirement in women with polycystic ovary syndrome.
    Endocr Connect 2017 Oct 10. Epub 2017 Oct 10.
    S Atkin, Research, Weill Cornell Medicine Qatar, Doha, 24144, Qatar.
    Background: There is an increased risk of developing T2DM in women with polycystic ovary syndrome (PCOS) and there is evidence that statins improve metabolic parameters in these patients. However, there is some data to show that statins increase the risk of incipient diabetes.

    Material And Methods: We have previously shown that 12-weeks of atorvastatin improves insulin resistance when measured using HOMA-IR. Read More

    Predictive factors for live birth after in vitro maturation of oocytes in women with polycystic ovary syndrome.
    Arch Gynecol Obstet 2017 Oct 9. Epub 2017 Oct 9.
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, McGill University Health Care Centre, Montreal, QC, Canada.
    Objective: In vitro maturation (IVM) of human oocytes can be an alternative treatment option to conventional in vitro fertilization. Women with polycystic ovary syndrome (PCOS) are considered the classical candidates for IVM because of the associated ovarian morphology and because IVM diminishes the risk of developing ovarian hyperstimulation syndrome. The objective of this study was to identify predictive factors for live birth in a cohort of women with PCOS who underwent IVM. Read More

    A Missense Variant rs4645843 in TNF-α Gene Is a Risk Factor of Polycystic Ovary Syndrome in the Uygur Population.
    Tohoku J Exp Med 2017 ;243(2):95-100
    Department of Reproductive Medicine, First Affiliated Hospital of Xinjiang Medical University.
    Polycystic ovary syndrome (PCOS) is a complex endocrine syndrome, resulting from the interaction of gene variants and environmental factors. PCOS is viewed as a proinflammatory state and is characterized by hyperandrogenism, hyperinsulinemia, and over-weight. In China, the incidence of PCOS is higher in the Uygur population than that in the Chinese Han population. Read More

    Defective insulin signaling and the protective effects of dimethyldiguanide during follicular development in the ovaries of polycystic ovary syndrome.
    Mol Med Rep 2017 Sep 29. Epub 2017 Sep 29.
    Provincial Key Laboratory for Developmental Biology and Neurosciences, College of Life Sciences, Fujian Normal University, Fuzhou, Fujian 350007, P.R. China.
    It is established that the physiological effects of insulin are primarily mediated by the insulin signaling pathway. However, a defective insulin signaling is closely associated with the clinical manifestations of polycystic ovary syndrome (PCOS), which include excess androgen levels, insulin resistance and anovulation, and is involved in the pathophysiology of PCOS at the molecular level. Dimethyldiguanide (DMBG) has been widely employed to alleviate reproduction dysfunction in women with PCOS, however, the exact mechanism of this effect remains unclear. Read More

    Effect of Metformin-sustained Release Therapy on Low-density Lipoprotein Size and Adiponectin in the South Indian Women with Polycystic Ovary Syndrome.
    Indian J Endocrinol Metab 2017 Sep-Oct;21(5):679-683
    Department of Reproductive Medicine, Sri Ramachandra Medical College, Porur, Chennai, Tamil Nadu, India.
    Objectives: The aim of the study is to compare surrogate markers of cardiovascular disease (CVD) risk, such as adiponectin (APN) levels and low-density lipoprotein (LDL) size, before and after sustained release metformin (Met-SR) therapy in women with polycystic ovarian syndrome (PCOS).

    Methods: Sixty women with PCOS and sixty age-matched controls in the age group 18-45 years were recruited after obtaining informed consent. Women with PCOS were initiated on Met-SR 1 g orally, which was increased to 1. Read More

    Apoptotic biomarkers in cumulus cells in relation to embryo quality in polycystic ovary syndrome.
    Arch Gynecol Obstet 2017 Oct 7. Epub 2017 Oct 7.
    Department of Anatomy, School of Medicine, Tehran University of Medical Science, 16 Azar Avenue, Poor Sina Street, Tehran, Iran.
    Purpose: To investigate associations between gene expression pattern of apoptotic biomarkers in cumulus cells of polycystic ovary syndrome (PCOS) patients and the quality of oocytes and embryos.

    Methods: 40 intracytoplasmic sperm injection patients, of whom 20 were PCOS and 20 were healthy women, were included in this study. Serum hormone levels were measured using Radioimmunoassay for each patient. Read More

    Ovulation induction and controlled ovarian stimulation using letrozole gonadotropin combination: A single center retrospective cohort study.
    Eur J Obstet Gynecol Reprod Biol 2017 Sep 23;218:123-128. Epub 2017 Sep 23.
    Reproductive Endocrinology and Infertility, Southwest Center for Reproductive Health, 700 S Mesa Hills Dr., El Paso, TX, 79912, USA. Electronic address:
    Objective: To assess the effect of letrozole in combination with low dose gonadotropins for ovulation induction in anovulatory infertility from polycystic ovary syndrome (PCOS) and controlled ovarian stimulation for endometriosis, and unexplained infertility patients.

    Study Design: Retrospective cohort study in a setting of private Reproductive Endocrinology and Infertility Clinic affiliated with the University. Three hundred couples (650 cycles) requiring OI/COS for PCOS (92 patients, 195 cycles), endometriosis (89 patients, 217 cycles), and unexplained infertility (119 patients, 238 cycles). Read More

    Nonhuman Primates: A Vital Model for Basic and Applied Research on Female Reproduction, Prenatal Development, and Women's Health.
    ILAR J 2017 Aug 28:1-14. Epub 2017 Aug 28.
    Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Beaverton, Oregon. Department of Obstetrics and Gynecology, Oregon Health & Sciences University, Portland, Oregon. Division of Reproductive Science in Medicine, Feinberg School of Medicine. Molecular Biosciences, Weinberg College of Arts and Sciences, Northwestern University in Chicago, Illinois.
    The comparative biology of reproduction and development in mammalian species is remarkable. Hence, because of similarities in environmental and neuroendocrine control of the reproductive axis, the cyclic function of the ovary and reproductive tract, establishment and control of the maternal-fetal-placental unit during pregnancy, and reproductive aging from puberty through menopause, nonhuman primates (NHPs) are valuable models for research related to women's reproductive health and its disorders. This chapter provides examples of research over the past 10+ years using Old World monkeys (notably macaque species), baboons, and to a lesser extent New World monkeys (especially marmosets) that contributed to our understanding of the etiology and therapies or prevention of: (1) ovarian disorders, e. Read More

    Abnormal expression levels of BMP15/Smad1 are associated with granulosa cell apoptosis in patients with polycystic ovary syndrome.
    Mol Med Rep 2017 Sep 28. Epub 2017 Sep 28.
    Department of Neurosurgery, The Tumor Hospital of Shanxi, Taiyuan, Shanxi 030000, P.R. China.
    Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects reproductive dysfunction and metabolism in women of childbearing age. An increasing number of studies have suggested that the bone morphogenetic protein 15 (BMP15) signalling pathway serves an important role in the pathogenesis of PCOS; however, the full mechanism remains unknown. The present study revealed that intrinsic follicular dysplasia may be associated with regulation disorders of ovarian granulosa cell apoptosis. Read More

    Obstetrical complications in dichorionic twin pregnancies in women with polycystic ovary syndrome.
    Acta Obstet Gynecol Scand 2017 Oct 5. Epub 2017 Oct 5.
    Department of Gynecology and Obstetrics, Hvidovre University Hospital, Copenhagen.
    Introduction: Both women with polycystic ovary syndrome (PCOS) and women with twin pregnancies have increased risk of adverse pregnancy outcome. The aim of this study was to investigate the impact of PCOS and maternal androgen levels on the outcome of dichorionic twin pregnancy.

    Material And Methods: A retrospective study of 360 women with dichorionic twin pregnancies: 72 PCOS women from a fertility clinic (years 1997 to 2010) and 288 non-PCOS women from a hospital cohort (years 2005 to 2007). Read More

    Comparison of myo-inositol and metformin on mental health parameters and biomarkers of oxidative stress in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial.
    J Psychosom Obstet Gynaecol 2017 Oct 5:1-8. Epub 2017 Oct 5.
    d Research Center for Biochemistry and Nutrition in Metabolic Diseases , Kashan University of Medical Sciences , Kashan , Iran.
    Introduction: Data on comparison of myo-inositol and metformin on mental health parameters and biomarkers of oxidative stress in subjects with polycystic ovary syndrome (PCOS) are scarce. This purpose of this study was to compare of myo-inositol and metformin on mental health parameters and biomarkers of oxidative stress in subjects with PCOS.

    Methods: This randomized controlled trial was conducted among 60 subjects diagnosed with PCOS according to the Rotterdam criteria. Read More

    Clinical Case Seminar: Post-menopausal ovarian androgen excess: challenges in diagnostic work-up and management of ovarian thecosis.
    Clin Endocrinol (Oxf) 2017 Oct 4. Epub 2017 Oct 4.
    Department of Endocrinology, Newcastle-upon-Tyne Hospitals, UK.
    A 72 year old female was referred to the Department of Endocrinology with a 20-year history of hirsutes, mostly affecting her face and torso, the initial onset of which dated shortly after menopause age 52 years. There was no history of subfertility, menstrual irregularity, or hyperandrogenism during reproductive life to suggest prior polycystic ovary syndrome (PCOS), with three live births, two miscarriages and one still-birth. This article is protected by copyright. Read More

    Identification of differentially expressed genes in pathways of cerebral neurotransmission of anovulatory mice.
    Genet Mol Res 2017 Sep 27;16(3). Epub 2017 Sep 27.
    Laboratório de Ginecologia Molecular, , , Brasil
    Polycystic ovary syndrome is the classic example of loss of functional cyclicity and anomalous feedback. In this case, the excessive extra-glandular production and conversion of androgens to estrogens are the pathophysiological basis of the chronic anovulation. The literature describes an experimental model of the polymicrocystic ovary in obese diabetic mice with insulin resistance. Read More

    Does polycystic ovary syndrome increase the risk of subclinical vascular disease in normal-weight type 1 diabetic women?
    Pol Arch Intern Med 2017 Sep 30. Epub 2017 Sep 30.
    INTRODUCTION The prevalence of polycystic ovary syndrome (PCOS) among type 1 diabetic women (T1DM) is higher than in general population. Both diseases are associated with higher risk of premature atherosclerosis. OBJECTIVES The aim of our study was to evaluate whether the cardiovascular risks conferred by T1DM and PCOS are additive. Read More

    Bioimpedance Measurements in Adolescents with Polycystic Ovary Syndrome: A Pilot Study.
    Adv Exp Med Biol 2017 ;987:291-299
    Clinical, Translational and Experimental Surgery Research Centre, Biomedical Research Foundation of Academy of Athens, 4 Soranou Ephessiou Street, 11527, Athens, Greece.
    Limited data are available on the body composition of adolescent women with polycystic ovary syndrome (PCOS). The aim of this study was to examine differences in body composition indices of metabolism, homeostasis and inflammation, between Greek adolescent females suffering from PCOS and age- and body mass index (BMI)-matched non-PCOS controls. Thirteen PCOS patients and nine non-PCOS controls, aged 13-24 years participated in this cross-sectional study. Read More

    Increased risk for diabetes mellitus in patients with carbon monoxide poisoning.
    Oncotarget 2017 Sep 29;8(38):63680-63690. Epub 2017 Jun 29.
    Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
    Carbon monoxide poisoning (COP) causes hypoxic injury and inflammatory and immunological reactions in the brain and local organs including the pancreas. Therefore, it is plausible that COP may increase the risk for developing diabetes mellitus (DM), but studies on this possible association are limited. We conducted a nationwide study in Taiwan to fill the data gap. Read More

    Selenium status parameters in patients with polycystic ovary syndrome.
    J Trace Elem Med Biol 2017 Dec 24;44:241-246. Epub 2017 Aug 24.
    Department of Gynecological Endocrinology, Medical College Jagiellonian University, Krakow, Poland.
    Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. To date, no systematic study of interactions between selenium status parameters (SSPs: serum selenium concentration, plasma glutathione peroxidase, GPX3, plasma selenoprotein P, SELENOP), sex hormones, thyroid function parameters, and other laboratory parameters in patients with PCOS has been undertaken. Therefore we aimed to compare such parameters in women with PCOS and in the control groups, and to investigate the multidimensional interactions between various parameters in PCOS patients and in controls. Read More

    Development of in vitro maturation techniques for clinical applications.
    Fertil Steril 2017 Oct;108(4):577-584
    Center for Reproductive Medicine, Tenth People's Hospital of Tongji University, Shanghai, People's Republic of China; Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada. Electronic address:
    In vitro maturation (IVM) refers to maturation in culture of immature oocytes at different stages that may or may not have been exposed to short courses of gonadotropins. The source of immature oocytes is an important feature for subsequent embryonic development, pregnancy, and healthy live births. IVM is an effective treatment that has already achieved significant outcomes of acceptable pregnancy and implantation rates and has led to the births of several thousand healthy babies. Read More

    Angiopoietin-like protein 8: An attractive biomarker for the evaluation of subjects with insulin resistance and related disorders.
    Diabetes Res Clin Pract 2017 Sep 8;133:168-177. Epub 2017 Sep 8.
    Department of Endocrinology, Affiliated Hospital of Jiangsu University, Zhenjiang, China. Electronic address:
    Insulin resistance is prevalent worldwide and is associated with many metabolic diseases, in particular, type 2 diabetes mellitus (T2DM), obesity, nonalcoholic fatty liver disease (NAFLD), polycystic ovary syndrome (PCOS) and metabolic syndrome (MetS). Angiopoietin-like protein 8 (ANGPTL8), a newly-identified secreted protein composing of 198 amino acids, is enriched in the liver of human. Considering its promising potential for β-cell proliferation and therapeutic prospect for diabetes, ANGPTL8 has aroused extensive interests. Read More

    Increased expression of PGRN protein in follicular fluid and mRNA in granulosa cells in overweight patients with polycystic ovary syndrome.
    Eur J Obstet Gynecol Reprod Biol 2017 Sep 19;218:106-112. Epub 2017 Sep 19.
    Reproductive Medical Center, Renmin Hospital of Wuhan University, Hubei Clinic Research Center for Assisted Reproductive Technology and Embryonic Development, JieFang Road 238, Wuhan, 430060, PR China; Obstetrics and Gynecology department, Renmin Hospital of Wuhan University, JieFang Road 238, Wuhan, 430060, China. Electronic address:
    Background: Obesity and low-grade chronic inflammation play critical roles in pathological process of PCOS. PGRN is an adipokine and was recently reported that it could induce a low-grade chronic inflammatory state and plays a functional role in insulin resistance associated with obesity. The overall goal of the present study was to evaluate the levels of PGRN in follicular fluid (FF) and the expression of PGRN in granulosa cells (GCs) with respect to the quality of the oocytes both in patients with PCOS and in the normal ovary during COH cycles. Read More

    Comparing the Effects of Oral Contraceptives Containing Levonorgestrel With Products Containing Antiandrogenic Progestins on Clinical, Hormonal, and Metabolic Parameters and Quality of Life in Women With Polycystic Ovary Syndrome: Crossover Randomized Controlled Trial Protocol.
    JMIR Res Protoc 2017 Sep 29;6(9):e191. Epub 2017 Sep 29.
    Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic Of Iran.
    Background: Oral contraceptives (OCs) have been used as a first-line option for medical treatment in women with polycystic ovary syndrome (PCOS). Despite theoretical superiority of products containing antiandrogenic progestins compared to OCs containing levonorgestrel (LNG), the clinical advantage of these compounds remains unclear.

    Objective: The aim of this study was to compare the effects of OCs containing LNG with products containing antiandrogenic progestins including cyproterone acetate, drospirenone, and desogestrel on clinical, hormonal, and metabolic parameters and quality of life in women with PCOS. Read More

    The Polycystic Ovary Syndrome-associated Gene Yap1 is Regulated by Gonadotropins and Sex Steroid Hormones in Hyperandrogenism-induced Oligo-ovulation in Mouse.
    Mol Hum Reprod 2017 Aug 10. Epub 2017 Aug 10.
    Life Sciences Institute, Zhejiang University, Hangzhou, China.
    Study Question: What is the physiological function of Yes-associated protein-1 (Yap1), a susceptibility gene for polycystic ovarian syndrome (PCOS), in ovarian granulosa cells?

    Summary Answer: Physiologically, steroid sex hormones stimulate follicle growth by activating YAP1; however, the preovulatory inhibition of YAP1 activity in granulosa cells is a prerequisite of LH actions.

    What Is Known Already: PCOS is a common gynecologic and endocrine disease with multiple short and long-term consequences. Many PCOS patients suffer anovulation caused by hyperandrogenism, but its etiology remains unclear. Read More

    Clinical and hormonal features of women with polycystic ovary syndrome living in rural and urban areas.
    Ann Agric Environ Med 2017 Sep 11;24(3):522-526. Epub 2017 May 11.
    Department of Gynecological Endocrinology, Poznan University of Medical Sciences, Poznan, Poland.
    Introduction: Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies among women at reproductive age, but its pathology remains unknown. From epidemiological studies it is known that endogenous, mainly genetic and exogenous, environmental factors are of importance.

    Objective: The aim of the study was to compare the phenotype of women diagnosed with PCOS from urban and rural areas of Poland. Read More

    Hypothalamic transcriptional expression of the kisspeptin system and sex steroid receptors differs among polycystic ovary syndrome rat models with different endocrine phenotypes.
    Clinics (Sao Paulo) 2017 Aug;72(8):510-514
    Laboratorio de Ginecologia Estrutural e Molecular (LIM 58), Disciplina de Ginecologia, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, BR.
    Objectives:: Polycystic ovary syndrome is a heterogeneous endocrine disorder that affects reproductive-age women. The mechanisms underlying the endocrine heterogeneity and neuroendocrinology of polycystic ovary syndrome are still unclear. In this study, we investigated the expression of the kisspeptin system and gonadotropin-releasing hormone pulse regulators in the hypothalamus as well as factors related to luteinizing hormone secretion in the pituitary of polycystic ovary syndrome rat models induced by testosterone or estradiol. Read More

    Effects of metformin treatment on serum levels of C-reactive protein and interleukin-6 in women with polycystic ovary syndrome: a meta-analysis: A PRISMA-compliant article.
    Medicine (Baltimore) 2017 Sep;96(39):e8183
    aDepartment of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang University bDepartment of Endocrinology and Metabolism, The Third Hospital of Nanchang, Nanchang, Jiangxi, China.
    Background: Metformin is effective for the treatment of polycystic ovary syndrome (PCOS), but conflicting results regarding its impact on serum levels of C-reactive protein (CRP) and interleukin-6 (IL-6) in women with PCOS have been reported. To provide high-quality evidence about the effect of treatment with metformin on CRP and IL-6 in PCOS, relevant studies that assessed the serum levels of CRP and IL-6 in women with PCOS receiving metformin treatment were reviewed and analyzed.

    Methods: A literature search was conducted in the Science Citation Index, PubMed, Embase, and Cochrane Library databases, and personal contact was made with the authors. Read More

    Polycystic ovary syndrome throughout a woman's life.
    J Assist Reprod Genet 2017 Sep 27. Epub 2017 Sep 27.
    Fundación Jiménez Díaz, Madrid, Spain.
    Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among reproductive-aged women and the main cause of infertility due to anovulation. However, this syndrome spans the lives of women affecting them from in-utero life until death, leading to several health risks that can impair quality of life and increase morbidity and mortality rates. Fetal programming may represent the beginning of the condition characterized by hyperandrogenism and insulin resistance which leads to a series of medical consequences in adolescence, adulthood, and old age. Read More

    Successful treatment with Korean herbal medicine and lifestyle management in an obese woman with polycystic ovarian syndrome.
    Integr Med Res 2017 Sep 23;6(3):325-328. Epub 2017 Jun 23.
    Department of Korean Obstetrics and Gynecology, Conmaul Hospital of Korean Medicine, Seoul, Korea.
    In Korea, herbal remedies have been widely used to treat polycystic ovarian syndrome (PCOS). We report the case of a woman with obese-type PCOS who was successfully treated with Korean herbal medicine (KHM) and lifestyle management. A 23-year-old female patient was first examined at our clinic in April 2015. Read More

    The effect of metformin use on pregnancy rates among polycystic ovary syndrome patients undergoing in vitro fertilization: A retrospective-cohort study.
    Saudi Pharm J 2017 Sep 14;25(6):906-910. Epub 2017 Feb 14.
    King Abdulaziz University Hospital, Riyadh, Saudi Arabia.
    Background: Metformin is widely used with gonadotropins by women with polycystic ovary syndrome (PCOS) during in vitro fertilization (IVF) to increase their chances of pregnancy. The aim of this study was to evaluate the efficacy of metformin in improving the rates of clinical pregnancy among women with PCOS undergoing IVF.

    Methods: This was a retrospective cohort study of women with PCOS, aged 18-40 years, undergoing IVF during 2006-2012 at a University Hospital in Riyadh, Saudi Arabia. Read More

    Pathway and network-based analysis of genome-wide association studies and RT-PCR validation in polycystic ovary syndrome.
    Int J Mol Med 2017 Sep 20. Epub 2017 Sep 20.
    Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, P.R. China.
    The purpose of this study was to identify promising candidate genes and pathways in polycystic ovary syndrome (PCOS). Microarray dataset GSE345269 obtained from the Gene Expression Omnibus database includes 7 granulosa cell samples from PCOS patients, and 3 normal granulosa cell samples. Differentially expressed genes (DEGs) were screened between PCOS and normal samples. Read More

    The effects of coenzyme Q10 supplementation on gene expression related to insulin, lipid and inflammation in patients with polycystic ovary syndrome.
    Gynecol Endocrinol 2017 Sep 26:1-6. Epub 2017 Sep 26.
    d Research Center for Biochemistry and Nutrition in Metabolic Diseases , Kashan University of Medical Sciences , Kashan , Iran.
    Objective: This research was conducted to assess the effects of coenzyme Q10 (CoQ10) intake on gene expression related to insulin, lipid and inflammation in subjects with polycystic ovary syndrome (PCOS).

    Methods: This randomized double-blind, placebo-controlled trial was conducted on 40 subjects diagnosed with PCOS. Subjects were randomly allocated into two groups to intake either 100 mg CoQ10 (n = 20) or placebo (n = 20) per day for 12 weeks. Read More

    Sex differences in the effect of prenatal testosterone exposure on steroid hormone production in adult rats.
    Physiol Res 2017 Sep;66(Supplementum 3):S367-S374
    Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
    Maternal hyperandrogenism during pregnancy might have metabolic and endocrine consequences on the offspring as shown for the polycystic ovary syndrome. Despite numerous experiments, the impact of prenatal hyperandrogenic environment on postnatal sex steroid milieu is not yet clear. In this study, we investigated the effect of prenatal testosterone excess on postnatal concentrations of luteinizing hormone, corticosterone and steroid hormones including testosterone, pregnenolone, progesterone, estradiol and 7beta-hydroxy-epiandrosterone in the offspring of both sexes. Read More

    Effect of TNF-α on Molecules Related to the Insulin Action in Endometrial Cells Exposed to Hyperandrogenic and Hyperinsulinic Conditions Characteristics of Polycystic Ovary Syndrome.
    Reprod Sci 2017 Jan 1:1933719117732157. Epub 2017 Jan 1.
    1 Laboratory of Endocrinology and Reproductive Biology, Clinical Hospital, University of Chile, Santiago, Chile.
    Polycystic ovary syndrome (PCOS) affects not only ovarian functions but is also able to affect endometrium metabolism. Around 80% of women with PCOS are obese. High tumor necrosis factor (TNF)-α production and low adiponectin levels are characteristics of obesity. Read More

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