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    [Pregnancy after Obesity and Metabolic Surgery - Risks and Complications].
    Zentralbl Chir 2018 Feb 22. Epub 2018 Feb 22.
    Klinik für Allgemein-, Viszeral- und Kinderchirurgie, SRH Wald-Klinikum Gera gGmbH, Deutschland.
    The increasing prevalence of morbid obesity in Germany is associated with an increasing number of metabolic surgical interventions. Short-term surgical and long-term metabolic complications - such as nutrient deficiencies - are the main risks of metabolic surgery and the resulting malabsorption. Obesity, especially morbid obesity, is associated with a high incidence of female infertility. Read More

    Effect of exposure to second-hand smoke from husbands on biochemical hyperandrogenism, metabolic syndrome and conception rates in women with polycystic ovary syndrome undergoing ovulation induction.
    Hum Reprod 2018 Feb 20. Epub 2018 Feb 20.
    Department of Obstetrics and Gynaecology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.
    Study Question: Does second-hand smoke (SHS) exposure from husbands have adverse effects on sex hormones, metabolic profiles, clinical phenotypes and fertility outcomes in women with polycystic ovary syndrome (PCOS) undergoing ovulation induction?

    Summary Answer: SHS exposure is associated with worsened biochemical hyperandrogenism, higher incidence of metabolic syndrome and reduced conception rates in women with PCOS.

    What Is Known Already: Smoking in women impairs fecundity at some stages of the reproductive process including folliculogenesis, embryo transport, endometrial angiogenesis and uterine blood flow. Yet little is known about the hazard of SHS exposure in women with PCOS. Read More

    Antiandrogen treatment ameliorates reproductive and metabolic phenotypes in the letrozole-induced mouse model of PCOS.
    Endocrinology 2018 Feb 19. Epub 2018 Feb 19.
    Department of Reproductive Medicine, Center for Reproductive Science and Medicine, University of California, San Diego, La Jolla, CA, USA.
    Polycystic ovary syndrome (PCOS), the most common endocrinopathy in women of reproductive age, is characterized by hyperandrogenism, anovulation, and polycystic ovaries. Although its etiology is unknown, excess androgens are thought to be a critical factor driving the pathology of PCOS. We previously demonstrated that continuous exposure to the aromatase inhibitor letrozole (LET) in mice produces many hallmarks of PCOS, including elevated testosterone (T) and luteinizing hormone (LH), anovulation, and obesity. Read More

    Influence of body mass index in anti-Müllerian hormone levels in 951 non-polycystic ovarian syndrome women followed at a reproductive medicine unit.
    Endocrine 2018 Feb 22. Epub 2018 Feb 22.
    Gynaecology, Obstetrics and Reproductive Medicine Department, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Lisbon, Portugal.
    Purpose: Anti-Müllerian hormone (AMH) is a useful marker of ovarian reserve. Obesity/overweight are increasing and may affect the reproductive health. Previous studies regarding the effect of body mass index (BMI) on AMH levels are discordant. Read More

    Determinants of Quality of Life and Satisfaction with Life in Women with Polycystic Ovary Syndrome.
    Int J Environ Res Public Health 2018 Feb 22;15(2). Epub 2018 Feb 22.
    Faculty of Health Sciences, Medical University of Lublin, 4-6 Staszica St., 20-081 Lublin, Poland.
    The purpose of the study was to assess the quality of life (QoL) and satisfaction with life (SwL) of women with polycystic ovary syndrome (PCOS) in comparison with those of healthy controls, and to identify and analyze factors determining QoL and SwL in women with PCOS. The cross-sectional study was performed between January and November 2016 in 504 women using health care services in Poland. The study group comprised women with PCOS, the control group women without PCOS. Read More

    Prenatal Androgen Exposure Causes Hypertension and Gut Microbiota Dysbiosis.
    Gut Microbes 2018 Feb 22:1-45. Epub 2018 Feb 22.
    a Department of Physiology and Pharmacology , The University of Toledo College of Medicine and Life Sciences , Toledo , OH.
    Background: Conditions of excess androgen in women, such as polycystic ovary syndrome (PCOS), often exhibit intergenerational transmission. One way in which the risk for PCOS may be increased in daughters of affected women is through exposure to elevated androgens in utero. Hyperandrogenemic conditions have serious health consequences, including increased risk for hypertension and cardiovascular disease. Read More

    Endocrinology and Pediatric Exercise Science-The Year That Was 2017.
    Pediatr Exerc Sci 2018 Feb 22:1-5. Epub 2018 Feb 22.
    1 Tel Aviv University.
    The Pediatric Exercise Science "Year That Was" section aims to highlight the most important (to the author's opinion) manuscripts that were published in 2017 in the field of endocrinology and pediatric exercise science. This year's selection includes studies showing that 1) in pubertal swimmers, there is a decrease in insulin-like growth factor-1 (IGF-I) and IGF-binding protein-3 (IGFBP-3) during intense training (a catabolic-type hormonal response) with an anabolic "rebound" characterized by a significant increase of these growth factors during training tapering down. Moreover, it was shown that changes of IGF-I and IGFBP-3 paralleled changes in peak and average force but not with endurance properties, showing decreases during intense training and increases during tapering; 2) a meta-analysis showing that growth hormone administration elicits significant changes in body composition and possible limited effect on anaerobic performance but does not increase either muscle strength or aerobic exercise capacity in healthy, young subjects; and 3) short-term exercise intervention can prevent the development of polycystic ovary syndrome in a dose-dependent manner in letrozole-induced polycystic ovary syndrome rat model with high-intensity exercise being most effective. Read More

    The effect of dietary soy intake on weight loss, glycaemic control, lipid profiles and biomarkers of inflammation and oxidative stress in women with polycystic ovary syndrome: a randomised clinical trial.
    J Hum Nutr Diet 2018 Feb 22. Epub 2018 Feb 22.
    Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.
    Background: The present study aimed to evaluate the effects of dietary soy intake on weight loss and metabolic status of patients with polycystic ovary syndrome (PCOS).

    Methods: A randomised clinical trial was conducted among 60 women with PCOS. Participants were randomly assigned into two groups to receive either a test diet (n = 30) or a control diet (n = 30) for 8 weeks. Read More

    The impact of serum adropin and ischemia modified albumin levels based on BMI in PCOS.
    Endokrynol Pol 2018 Feb 21. Epub 2018 Feb 21.
    Konya Education and Research Hospital, Meram Yeni Yol, 042090 Konya, Turkey.
    Introduction: The aim of this study was to evaluate the effects of polycystic ovary syndrome (PCOS) and body mass index (BMI) on serum adropin and ischemia modified albumin (IMA) levels.

    Materials And Methods: This prospective cross-sectional study was performed with a total of 120 women [group1; non-PCOS = 60 (BMI <25 = 30, BMI ≥25 = 30) and group 2; PCOS = 60 (BMI <25 = 30, BMI ≥25 = 30)]. Blood samples were collected between the third and fifth days of the women's menstrual cycles after a night of fasting. Read More

    Insulin resistance in an animal model of polycystic ovary disease is aggravated by vitamin D deficiency: Vascular consequences.
    Diab Vasc Dis Res 2018 Feb 1:1479164118758580. Epub 2018 Feb 1.
    3 Department of Physiology, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
    Hyperandrogenic state in females is accompanied with metabolic syndrome, insulin resistance and vascular pathologies. A total of 67%-85% of hyperandrogenic women suffer also from vitamin D deficiency. We aimed to check a potential interplay between hyperandrogenism and vitamin D deficiency in producing insulin resistance and effects on coronary resistance arteries. Read More

    The role of FTO variants in the susceptibility of polycystic ovary syndrome and in vitro fertilization outcomes in Chinese women.
    Gynecol Endocrinol 2018 Feb 20:1-5. Epub 2018 Feb 20.
    a Institute of Biology, School of Pharmaceutical and Biological Science , University of South China , Hengyang , PR China.
    We investigated the association between single nucleotide polymorphisms (SNPs) in the fat mass and obesity associated (FTO) gene (rs9926289 A/G, rs79206939 A/G, rs9930506 A/G, rs8050136 A/C, and rs1588413 C/T) and polycystic ovary syndrome (PCOS), as well as outcomes of in vitro fertilization (IVF). A case-control study consisting of 147 PCOS patients and 120 healthy controls was conducted. FTO SNPs were genotyped by PCR to determine allelic frequencies, and IVF outcomes were analyzed. Read More

    The Biased G-Protein-Coupled Receptor Agonism Bridges the Gap between the Insulin Receptor and the Metabolic Syndrome.
    Int J Mol Sci 2018 Feb 17;19(2). Epub 2018 Feb 17.
    Department of Biomedical and Molecular Science, Queen's University, Kingston, ON K7L 3N6, Canada.
    Insulin signaling, as mediated through the insulin receptor (IR), plays a critical role in metabolism. Aberrations in this signaling cascade lead to several pathologies, the majority of which are classified under the umbrella term "metabolic syndrome". Although many of these pathologies are associated with insulin resistance, the exact mechanisms are not well understood. Read More

    The Diagnostic Value of Anti-Mullerian Hormone in Early Post Menarche Adolescent Girls with Polycystic Ovarian Syndrome.
    J Pediatr Adolesc Gynecol 2018 Feb 17. Epub 2018 Feb 17.
    Department of Pediatric Endocrinology, Ankara University School of Medicine, Ankara, Turkey.
    Study Objective: Polycystic ovarian syndrome (PCOS) is a common endocrine disorder characterized by hyperandrogenism and chronic anovulation, which affects 5-10% of reproductive age females. Diagnosis of adult patients with PCOS is made easily with clinical and laboratory methods and the antimullerian hormone (AMH) level are accepted as a good indicator. However, there is still no complete consensus on the diagnosis of PCOS in adolescents. Read More

    Gonadotropins and their receptors: co-evolution, genetic variants, receptor imaging, and functional antagonists.
    Biol Reprod 2018 Feb 15. Epub 2018 Feb 15.
    Program of Reproductive and Stem Cell Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305, USA.
    Gonadotropins belong to the family of dimeric glycoprotein hormones and regulate gonadal physiology mediated by G protein-coupled, seven-transmembrane receptors. These glycoprotein hormones are widely used in the clinic to promote ovarian follicle development and for treating some cases of male infertility. We traced the co-evolution of dimeric gonadotropin hormones and their receptors, together with thyrotropin and its receptor. Read More

    Polycystic ovary syndrome and adverse pregnancy outcomes: current state of knowledge, challenges and potential implications for practice.
    Clin Endocrinol (Oxf) 2018 Feb 20. Epub 2018 Feb 20.
    Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, VIC, Australia.
    Although there is a growing body of literature reporting that pregnancies in women with polycystic ovary syndrome (PCOS) are associated with greater complications than those without PCOS, methodological differences across studies make these results difficult to consolidate. This narrative review outlines potential mechanisms involved in adverse pregnancy outcomes in PCOS and the nature of the complications. It covers limitations of current evidence and future research directions. Read More

    Postnatal depression in a community-based study of women with polycystic ovary syndrome.
    Acta Obstet Gynecol Scand 2018 Feb 20. Epub 2018 Feb 20.
    School of Public Health, The University of Adelaide, Adelaide.
    Introduction: Women with polycystic ovary syndrome (PCOS) are susceptible to depression and anxiety, so may also be at risk for postnatal depression (PND). This study investigates whether women with PCOS have an elevated risk of PND.

    Material And Methods: Cross-sectional data for parous women (n=566) were available from a birth cohort. Read More

    Effects of combined oral contraceptives on the clinical and biochemical parameters of hyperandrogenism in patients with polycystic ovary syndrome: a systematic review and meta-analysis.
    Eur J Contracept Reprod Health Care 2018 Feb 19:1-14. Epub 2018 Feb 19.
    b Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences , Shahid Beheshti University of Medical Sciences , Tehran , Iran.
    Introduction: Nowadays, selection of COCs with maximum antiandrogenic effects is one the main issues in treatment of women with polycystic ovary syndrome (PCOS).

    Objective: This systematic review and meta-analysis aimed to compare the effects of COCs on the clinical and biochemical parameters of hyperandrogenism (HA) in patients with PCOS.

    Methods: Electronic databases (PubMed, Scopus, ScienceDirect and web of science) were searched from 1987 to November 2015 to identify clinical trials investigating effect of the various COCs on the clinical and biochemical parameters of HA in patients. Read More

    Evaluation ofandmRNAs expressions in visceral and subcutaneous adipose tissues of polycystic ovarian rats and effects of resveratrol.
    Iran J Basic Med Sci 2018 Feb;21(2):165-174
    Department of Biology, Faculty of Sciences, Razi University, Kermanshah, Iran.
    Objectives: Some studies suggest that chronic low-grade inflammation is involved in insulin resistance in polycystic ovary syndrome (PCOS). This study assessed possible involvement of alteration in expression of two pro-inflammatory factors, tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in adipose tissues of PCOS rats in the impairment of insulin actions. Also, effects of resveratrol as an anti-inflammatory agent were investigated. Read More

    Tight interplay in early pregnancy between follistatin and anti-mullerian hormone in women with polycystic ovarian syndrome (PCOS).
    Arch Gynecol Obstet 2018 Feb 16. Epub 2018 Feb 16.
    Department of Gynecology and Obstetrics, University of Duisburg-Essen, Hufelandstrasse 55, 45122, Essen, Germany.
    Purpose: Follistatin levels increase during the course of pregnancy and may play a role in ovarian arrest, reflected by the simultaneous decrease of anti-mullerian-hormone (AMH) levels. The aim of the study was to investigate AMH and follistatin levels during the hormonal window at the beginning of pregnancy. Since both parameters are described as deregulated in polycystic ovarian syndrome (PCOS), subgroup analysis of PCOS patients may additionally elucidate their interplay and effects on ovarian activity. Read More

    Women-specific risk factors for heart failure: A genetic approach.
    Maturitas 2018 Mar 30;109:104-111. Epub 2017 Dec 30.
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands. Electronic address:
    Heart failure is a complex disease, which is presented differently by men and women. Several studies have shown that reproductive factors, such as age at natural menopause, parity and polycystic ovarian syndrome (PCOS), may play a role in the development of heart failure. Shared genetics may provide clues to underlying mechanisms; however, this has never been examined. Read More

    Supplementation with omega-3 fatty acids and plasma adiponectin in women with polycystic ovary syndrome.
    Endocrinol Diabetes Nutr 2018 Feb 13. Epub 2018 Feb 13.
    Universidad Estatal de Milagro, Milagro, Ecuador.
    Objective: To study plasma adiponectin levels in women diagnosed with polycystic ovary syndrome given omega-3 fatty acid supplements.

    Patients And Methods: A study was conducted in 195 women diagnosed with polycystic ovary syndrome treated with omega-3 fatty acids for 12weeks (n=97; groupA) and control women given placebo (n=98, groupB). General characteristics, metabolism, lipid profile, and hormone and adiponectin levels were compared. Read More

    Vitamin D, PCOS and androgens in men: a systematic review.
    Endocr Connect 2018 Feb 15. Epub 2018 Feb 15.
    E Lerchbaum, Graz, Austria
    Background: Accumulating evidence from animal and human studies suggests that vitamin D is involved in many functions of the reproductive system in both genders.

    Aim: The aim of this review was to provide an overview on the effects of vitamin D on polycystic ovary syndrome (PCOS) in women and androgen metabolism in men.

    Methods: We performed a systematic literature search in Pubmed for relevant English language publications published from January 2012 until July 2017. Read More

    Metformin as an adjunct therapy for the treatment of moderate to severe acne vulgaris.
    Dermatol Online J 2017 Nov 15;23(11). Epub 2017 Nov 15.
    Lincoln Memorial University-DeBusk College of Osteopathic Medicine.
    The purpose of this literature review is to evaluate the use of metformin as an adjunct therapy in the treatment of moderate-to-severe acne in those not diagnosed with polycystic ovary syndrome (PCOS) or androgen excess. The authors conducted independent literature searches. Results were limited to clinical trials and randomized controlled trials. Read More

    Association between Th1/Th2 immune imbalance and obesity in women with or without polycystic ovary syndrome.
    Gynecol Endocrinol 2018 Feb 15:1-6. Epub 2018 Feb 15.
    a Department of Obstetrics and Gynecology , Changzhou Hospital of Traditional Chinese Medicine, Nanjing University of Chinese Medicine , Changzhou , China.
    Objectives: This study aimed to investigate the Th1/Th2 cells in peripheral blood of PCOS patients, and assess the potential correlation between Th1/Th2 imbalance and obesity.

    Methods: Thirty-nine PCOS patients and 23 age-matched controls were enrolled. The PBMCs were obtained before pharmacological intervention in women with or without PCOS. Read More

    Sirtuins in gamete biology and reproductive physiology: emerging roles and therapeutic potential in female and male infertility.
    Hum Reprod Update 2018 Feb 13. Epub 2018 Feb 13.
    Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
    Background: Sirtuins (SIRT1-7) are a family of NAD+-dependent deacetylases that catalyze post-translational modifications of proteins. Together, they respond to metabolic challenges, inflammatory signals or hypoxic/oxidative stress, and are associated with aging and longevity. The role of Sirtuins in the regulation of fertility emerged in 2003 when a defective reproductive phenotype was observed in SIRT1-null mice. Read More

    Aerobic Training Improves Quality of Life in Women with Polycystic Ovary Syndrome.
    Med Sci Sports Exerc 2018 Feb 13. Epub 2018 Feb 13.
    Department of Physical Education, Federal University of Rio Grande do Norte, Natal, Brazil.
    Purpose: To investigate the effects of a supervised aerobic exercise training intervention on health-related quality of life (HRQL), cardiorespiratory fitness, cardiometabolic profile, and affective response in overweight/obese women with polycystic ovary syndrome (PCOS).

    Methods: Twenty-seven overweight/obese inactive women with PCOS (body mass index, BMI ≥ 25 kg/m; aged from 18 to 34 years) were allocated into an exercise group (n = 14) and a control group (n = 13). Progressive aerobic exercise training was performed three times per week (~150 min/week) over 16 weeks. Read More

    Sleep disturbances in women with polycystic ovary syndrome: prevalence, pathophysiology, impact and management strategies.
    Nat Sci Sleep 2018 1;10:45-64. Epub 2018 Feb 1.
    The University of Adelaide, Robinson Research Institute, Adelaide, SA, Australia.
    Polycystic ovary syndrome (PCOS) is a complex endocrine disorder affecting the reproductive, metabolic and psychological health of women. Clinic-based studies indicate that sleep disturbances and disorders including obstructive sleep apnea and excessive daytime sleepiness occur more frequently among women with PCOS compared to comparison groups without the syndrome. Evidence from the few available population-based studies is supportive. Read More

    Adult-onset acne: prevalence, impact, and management challenges.
    Clin Cosmet Investig Dermatol 2018 1;11:59-69. Epub 2018 Feb 1.
    Paulista Medical School, Universidade Federal de São Paulo (Federal University of São Paulo), São Paulo, SP, Brazil.
    Acne is a multifactorial and inflammatory disease of pilosebaceous follicles, which affects most adolescents. Recent epidemiological data revealed a difference in adults affected by this disease. Women have a high prevalence and incidence when compared with men, especially after 25 years of age. Read More

    Elevated CD14CD16Monocytes in Hyperhomocysteinemia-Associated Insulin Resistance in Polycystic Ovary Syndrome.
    Reprod Sci 2018 Jan 1:1933719118756772. Epub 2018 Jan 1.
    1 Department of Obstetrics and Gynecology, Center for Reproductive Medicine, Peking University Third Hospital, Beijing, China.
    Background: Hyperhomocysteinemia, chronic low-grade inflammation, and insulin resistance are predominant features in women with polycystic ovary syndrome (PCOS). CD14CD16inflammatory monocytes are elevated in cardiovascular diseases and diabetes, in which inflammation is one of the pathogenesis. We aimed to determine whether homocysteine levels are associated with monocyte subtypes or insulin resistance in women with PCOS. Read More

    Dysregulated genes and their functional pathways in luteinized granulosa cells from PCOS patients after Cabergoline-treatment.
    Reproduction 2018 Feb 9. Epub 2018 Feb 9.
    A Pellicer, Research, Fundación IVI, Instituto Universitario IVI, Valencia, Spain.
    Polycystic ovarian syndrome (PCOS) is a common reproductive disorder frequently associated with a substantial risk factor for ovarian hyperstimulation syndrome (OHSS). Dopamine receptor 2 (D2) agonists, like Cabergoline (Cb2), have been used to reduce the OHSS risk. However, lutein granulosa cells (LGCs) from PCOS patients treated with Cb2 still show a deregulated dopaminergic tone (decreased D2 expression and low dopamine production) and increased vascularization compared to non-PCOS LGCs. Read More

    Limitations of insulin resistance assessment in polycystic ovary syndrome.
    Endocr Connect 2018 Feb 7. Epub 2018 Feb 7.
    A Lewinski, Department of Endocrinology and Metabolic Diseases, Medical University of Lodz, Lodz, Poland
    Backgroud: Though insulin resistance (IR) is common in polycystic ovary syndrome (PCOS), there is no agreement as to what surrogate method of assessment of IR is most reliable.

    Subjects And Methods: In 478 women with PCOS we compared methods based on fasting insulin and either fasting glucose (HOMA-IR and QUICKI), or triglycerides (McAuley Index) with IR indices derived from glucose and insulin during OGTT (Belfiore, Matsuda and Stumvoll indices).

    Results: There was a strong correlation between IR indices derived from fasting values HOMA-IR/QUICKI, r=-0. Read More

    Lipidomics reveals altered biosynthetic pathways of glycerophospholipids and cell signaling as biomarkers of the polycystic ovary syndrome.
    Oncotarget 2018 Jan 17;9(4):4522-4536. Epub 2017 Dec 17.
    Department of Experimental Medicine, Lleida University-Institute for Research in Biomedicine of Lleida (UdL-IRBLleida), 25198 Lleida, Spain.
    Purpose: In this work, a non-targeted approach was used to unravel changes in the plasma lipidome of PCOS patients. The aim is to offer new insights in PCOS patients strictly selected in order to avoid confounding factors such as dyslipemia, obesity, altered glucose/insulin metabolism, cardiovascular disease, or cancer.

    Results: Multivariate statistics revealed a specific lipidomic signature for PCOS patients without associated pathologies. Read More

    Metformin and pioglitazone combination therapy ameliorate polycystic ovary syndrome through AMPK/PI3K/JNK pathway.
    Exp Ther Med 2018 Feb 15;15(2):2120-2127. Epub 2017 Dec 15.
    Reproductive Medicine Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
    Polycystic ovary syndrome (PCOS) is a common gynecological endocrine disorder, which results in health problems such as menstrual disorders, hyperandrogenism and persistent anovulation. Hyperandrogenism and insulin resistance are the basic characteristics of PCOS. To investigate the combined effect of metformin and pioglitazone on POCS and the potential mechanisms, a rat model of PCOS was established by intramuscular injection of estradiol valerate (EV). Read More

    LncRNA-LET inhibits cell viability, migration and EMT while induces apoptosis by up-regulation of TIMP2 in human granulosa-like tumor cell line KGN.
    Biomed Pharmacother 2018 Feb 9;100:250-256. Epub 2018 Feb 9.
    Department of Obstetrics and Gynecology, Liaocheng People's Hospital, Liaocheng 252000, China.
    Background: Polycystic ovary syndrome (PCOS) is a common endocrine disease characterized by hyperandrogenism, irregular menses, and polycystic ovaries. Several long non-coding RNAs (lncRNAs) are aberrantly expressed in PCOS patients; however, little is known about the effects of the lncRNA-low expression in tumor (lncRNA-LET) on PCOS. We aimed to explore the effects of lncRNA-LET on human granulosa-like tumor cell line, KGN. Read More

    Prevalence of comorbid conditions pre-existing and diagnosed at a tertiary care pediatric weight management clinic.
    J Pediatr Endocrinol Metab 2018 Feb 13. Epub 2018 Feb 13.
    University of Calgary, Calgary, Alberta, Canada.
    Background: Childhood obesity places individuals at risk for a multitude of physical and mental health problems. The aim of this study was to assess the prevalence of obesity related comorbidities diagnosed prior to and after attending a tertiary care pediatric weight management clinic.

    Methods: A cross sectional retrospective chart review of patients 2-17 years old seen in the weight management clinic at Alberta Children's Hospital from May 2012 to May 2014. Read More

    IGF-1R and Leptin Expression Profile and the Effects of Metformin Treatment on Metabolic and Endocrine Parameters in PCOS Mice.
    Biomed Res Int 2017 21;2017:9058307. Epub 2017 Dec 21.
    Climacteric Section, Department of Obstetrics and Gynecology, Universidade Federal de São Paulo Escola Paulista de Medicina (UNIFESP/EPM), 66 Embaú Street, Vila Clementino, 04039-060 São Paulo, SP, Brazil.
    We aim to assess the effects of metformin treatment on metabolic and endocrine parameters and genes expression related to the insulin-responsive pathway in polycystic ovary syndrome (PCOS). This study comprises twenty-eight obese mice divided into three metformin-treated groups for seven and twenty days and eight nonobese and nontreated ones. We found a significant decrease in glycemia after metformin treatment at days seven and twenty. Read More

    Repeat Dose of Gonadotropin-releasing Hormone Agonist Trigger in Polycystic Ovarian Syndrome UndergoingFertilization Cycles Provides a Better Cycle Outcome - A proof-of-concept Study.
    J Hum Reprod Sci 2017 Oct-Dec;10(4):271-280
    Department of Reproductive Medicine, Milann, The Fertility Center, (A Unit of BACC Healthcare Pvt Ltd.), Bengaluru, Karnataka, India.
    Objective: Is a single dose of gonadotropin-releasing hormone agonist (GnRHa) trigger to induce final oocyte maturation in polycystic ovarian syndrome (PCOS) undergoingfertilization (IVF) cycles with GnRH antagonist protocol sufficient to provide optimal oocyte maturity?

    Design: This is a prospective, randomized, double-blind, proof-of-concept study.

    Setting: This study was carried out at a tertiary care center.

    Material And Methods: A total of 125 patients diagnosed with PCOS defined as per the ESHRE/ASRM Rotterdam criteria (2003) undergoing IVF in antagonist protocol were randomized into two groups. Read More

    Ovulation Induction Using Clomiphene Citrate Using Stair - Step Regimen versus Traditional Regimen in Polycystic Ovary Syndrome Women - A Randomized Control Trial.
    J Hum Reprod Sci 2017 Oct-Dec;10(4):261-264
    Department of Obstetrics and Gynecology, PGIMER, Chandigarh, India.
    Objective: To determine the efficacy of the stair-step protocol (SSP) using clomiphene citrate (CC) in patients with polycystic ovary syndrome (PCOS) and compare it with traditional regimen.

    Design: This was randomized control trial.

    Setting: Infertility Clinic. Read More

    The preliminary association study of ADIPOQ, RBP4, and BCMO1 variants with polycystic ovary syndrome and with biochemical characteristics in a cohort of Polish women.
    Adv Med Sci 2018 Feb 7;63(2):242-248. Epub 2018 Feb 7.
    Department of Reproduction and Gynecological Endocrinology, Medical University of Białystok, Białystok, Poland.
    Purpose: We aimed to elucidate the frequency of the SNPs in the ADIPOQ, RBP4 and BCMO1genes in a population of Caucasian Polish women with polycystic ovary syndrome (PCOS), and to evaluate the possible associations between these variants and the susceptibility to PCOS. Additionally, the relationship of these polymorphisms to a clinical phenotype of this syndrome, and the concentrations of adipokines, were determined.

    Materials/methods: Clinical and biochemical profiles, DNA isolation and genotyping, and adipokine assays were performed in 294 PCOS women and 78 controls. Read More

    Association of testosterone and antimüllerian hormone with time to pregnancy and pregnancy loss in fecund women attempting pregnancy.
    Fertil Steril 2018 Feb 7. Epub 2018 Feb 7.
    Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.
    Objective: To examine whether higher T and/or antimüllerian hormone (AMH) was associated with anovulation, time to pregnancy (TTP), or pregnancy loss risk among healthy, fecund women without diagnosed polycystic ovary syndrome.

    Design: Prospective cohort study conducted as a secondary analysis from the Effects of Aspirin in Gestation and Reproduction randomized trial.

    Setting: University medical centers. Read More

    Reproductive and metabolic determinants of granulosa cell dysfunction in normal-weight women with polycystic ovary syndrome.
    Fertil Steril 2018 Feb 7. Epub 2018 Feb 7.
    Department of Obstetrics and Gynecology, University of California, Los Angeles, California. Electronic address:
    Objective: To determine the degree to which Ehyperresponsiveness to FSH and antimüllerian hormone (AMH) overproduction in normal-weight women with polycystic ovary syndrome (PCOS) correlate with increased antral follicle number (AFN), hyperandrogenism, and/or metabolic dysfunction.

    Design: Prospective cohort study.

    Setting: Academic medical center. Read More

    Impact of cancer treatment on risk of infertility and diminished ovarian reserve in women with polycystic ovary syndrome.
    Fertil Steril 2018 Feb 7. Epub 2018 Feb 7.
    Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia.
    Objective: To compare markers of fertility and ovarian reserve between cancer survivors and cancer-free women with and without polycystic ovary syndrome (PCOS).

    Design: Furthering Understanding of Cancer, Health, and Survivorship in Adult (FUCHSIA) Women's Study-a population-based cohort study.

    Setting: Not applicable. Read More

    Differential rate in decline in ovarian reserve markers in women with polycystic ovary syndrome compared with control subjects: results of a longitudinal study.
    Fertil Steril 2018 Feb 7. Epub 2018 Feb 7.
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco School of Medicine, San Francisco, California.
    Objective: To estimate rates of ovarian aging in polycystic ovary syndrome (PCOS) subjects versus a community control population.

    Design: Longitudinal.

    Setting: Tertiary academic center. Read More

    High-molecular-weight adiponectin is inversely associated with sympathetic activity in polycystic ovary syndrome.
    Fertil Steril 2018 Feb 7. Epub 2018 Feb 7.
    Monash Centre for Health Research and Implementation, Monash University, Clayton, Victoria, Australia; Diabetes and Vascular Medicine Unit, Monash Health, Melbourne, Victoria, Australia. Electronic address:
    Objective: To examine the role of high-molecular-weight (HMW) adiponectin and its relationship to sympathetic activity in women with polycystic ovary syndrome (PCOS).

    Design: Cross sectional study using biobanked samples.

    Setting: Not applicable. Read More

    The correlation between serum AMH and HOMA-IR among PCOS phenotypes.
    BMC Res Notes 2018 Feb 9;11(1):114. Epub 2018 Feb 9.
    Division of Reproductive Endocrinology and Infertility, Department of Obstetric and Gynecology Faculty of Medicine, Universitas Indonesia; Dr, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia.
    Background: Polycystic ovarian syndrome (PCOS) is known to be one of the most prevalent endocrine disorders affecting reproductive age women. One of the endocrine disorder is hyperinsulinemia, which corresponds with the severity of PCOS. However, the pathogenesis of PCOS is not fully understood, but one theory of anti-mullerian hormone (AMH) has been proposed as one of the factor related to the degree of severity of PCOS. Read More

    The numbers of 2- 5 and 6-9 mm ovarian follicles are inversely correlated in both normal women and in polycystic ovary syndrome patients: what is the missing link?
    Hum Reprod 2018 Feb 7. Epub 2018 Feb 7.
    CHU Lille, Service de Gynécologie-Endocrinienne et Médecine de la Reproduction, Hôpital Jeanne de Flandre, rue Eugène Avinée 59000, Lille, France.
    Study Question: Is the negative correlation between the numbers of 2-5 and 6-9 mm follicles influenced by ovarian and/or metabolic parameter(s) in young control women and in patients with polycystic ovarian syndrome (PCOS)?

    Summary Answer: Our study confirmed that the negative correlation between numbers of follicles sized 2-5 and 6-9 mm was stronger in PCOS than in young control women and was not linked to any ovarian or metabolic parameter.

    What Is Known Already: Previous reports described a direct negative correlation between the number of small antral follicles (2-5 mm) and large antral follicle (6-9 mm) during the early follicular phase (cycle Days 2-5) in normal and PCOS women. Numerous factors, that could be either intrinsic to the ovary or secondary to metabolic influence and/or gonadotropin regulation, might account for this. Read More

    Risk of Type 2 Diabetes Mellitus following Gestational Diabetes Pregnancy in Women with Polycystic Ovary Syndrome.
    J Diabetes Res 2017 20;2017:5250162. Epub 2017 Dec 20.
    Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
    Background: This study examines gestational diabetes mellitus (GDM) in women with polycystic ovary syndrome (PCOS) and the risk of type 2 diabetes mellitus (DM) following GDM pregnancy.

    Methods: A cohort of 988 pregnant women with PCOS who delivered during 2002-2005 was examined to determine the prevalence and predictors of GDM, with follow-up through 2010 among those with GDM to estimate the risk of DM.

    Results: Of the 988 pregnant women with PCOS, 192 (19%) developed GDM. Read More

    Polycystic ovary syndrome in mitochondrial disorders due mtDNA or nDNA variants.
    Am J Transl Res 2018 15;10(1):13-15. Epub 2018 Jan 15.
    University of Tunis El Manar and Genomics Platform, Pasteur Institute of TunisTunis, Tunisia.
    Objectives: Whether polycystic ovary syndrome (PCOS) is associated with mtDNA or nDNA mutations causing mitochondrial disorders (MIDs) or not is under debate. This review aims at summarising and discussing previous and recent findings concerning the frequency, diagnosis, and treatment of PCOS in MIDs.

    Methods: Systematic literature review using appropriate search terms. Read More

    Metformin and cancer: An existing drug for cancer prevention and therapy.
    Oncol Lett 2018 Jan 14;15(1):683-690. Epub 2017 Nov 14.
    Bone Marrow Transplantation Center, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, P.R. China.
    Metformin is a standard clinical drug used to treat type 2 diabetes mellitus (T2DM) and polycystic ovary syndrome. Recently, epidemiological studies and meta-analyses have revealed that patients with T2DM have a lower incidence of tumor development than healthy controls and that patients diagnosed with cancer have a lower risk of mortality when treated with metformin, demonstrating an association between metformin and tumorigenesis.andstudies have revealed that metformin has a direct antitumor effect, which may depress tumor proliferation and induce the apoptosis, autophagy and cell cycle arrest of tumor cells. Read More

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