16,934 results match your criteria Polycystic Ovarian Syndrome


Role of PCSK9 in PCOS.

Metabolism 2019 Feb 12. Epub 2019 Feb 12.

Department of Physiology, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Sichuan, Chengdu, China. Electronic address:

Background: Proprotein convertase subtilisin / kexin type 9 (PCSK9) plays a critical role in the cholesterol metabolism by negatively regulating the low-density lipoprotein receptor (LDLR). Lipid metabolic and ovarian disorders are the common clinical manifestation of polycystic ovary syndrome (PCOS). Here, we intended to elucidate the role of PCSK9 in the pathogenesis of PCOS conducted on a human population in case-control design and animal part in an interventional study. Read More

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http://dx.doi.org/10.1016/j.metabol.2019.02.002DOI Listing
February 2019

Hyperandrogenic origins of polycystic ovary syndrome - implications for pathophysiology and therapy.

Expert Rev Endocrinol Metab 2019 Jan 31:1-13. Epub 2019 Jan 31.

a Department of Obstetrics and Gynecology , University of Wisconsin , Madison , WI , USA.

Introduction: Polycystic ovary syndrome (PCOS) diagnosis comprises combinations of female hyperandrogenism, menstrual irregularity and polycystic ovaries. While it is a familial and highly prevalent endocrine disorder, progress towards a cure is hindered by absence of a definitive pathogenic mechanism and lack of an animal model of naturally occurring PCOS. Areas covered: These include an overview of PCOS and its potential etiology, and an examination of insights gained into its pathogenic origins. Read More

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http://dx.doi.org/10.1080/17446651.2019.1576522DOI Listing
January 2019

Association of vitamin D receptor gene variants with polycystic ovary syndrome: a meta-analysis.

BMC Med Genet 2019 Feb 14;20(1):32. Epub 2019 Feb 14.

Zhejiang Hospital, Department of nutrition, Hangzhou, 310013, Zhejiang Province, China.

Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in reproductive-age women. Multiple susceptible gene as well as environmental factors and their interaction each other are contributed to the PCOS risk. Several case-control studies have researched the associations of the vitamin D receptor gene (VDR) polymorphisms with PCOS susceptibility, but the jury is still out. Read More

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http://dx.doi.org/10.1186/s12881-019-0763-5DOI Listing
February 2019

Complex diseases and co-morbidities: polycystic ovary syndrome and type 2 diabetes mellitus.

Endocr Connect 2019 Feb 1. Epub 2019 Feb 1.

H Teede, Monash Centre for Health Research and Implementation, Monash University, Clayton, Australia.

Objective: Many complex diseases exhibit co-morbidities often requiring management by more than one health specialist. We examined cross-speciality issues that ultimately affect the health and wellbeing of patients with polycystic ovary syndrome (PCOS). PCOS was originally described as a reproductive condition but is now recognised to also be a metabolic and psychological condition affecting 8-13% of women of reproductive age. Read More

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https://ec.bioscientifica.com/view/journals/ec/aop/ec-18-050
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http://dx.doi.org/10.1530/EC-18-0502DOI Listing
February 2019
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Increased risk of obstructive sleep apnoea in women with polycystic ovary syndrome: a population-based cohort study.

Eur J Endocrinol 2019 Feb 1. Epub 2019 Feb 1.

K Nirantharakumar, Institute of Applied Health Research, University of Birmingham, Birmingham, United Kingdom of Great Britain and Northern Ireland.

Objective: Obesity is very common in patients with obstructive sleep apnoea (OSA) and polycystic ovary syndrome (PCOS). Longitudinal studies assessing OSA risk in PCOS and examining the role of obesity are lacking. Our objective was to assess the risk of OSA in women with vs. Read More

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http://dx.doi.org/10.1530/EJE-18-0693DOI Listing
February 2019

Treatment for polycystic ovary syndrome: a critical appraisal of treatment options.

Authors:
Shahla Nader

Expert Rev Endocrinol Metab 2008 May;3(3):349-359

a Professor, Departments of Obstetrics and Gynecology and Internal Medicine (Endocrinology), University of Texas Medical School - Houston, 6431 Fannin Street, Suite 3604, Houston, TX 77030, USA.

The management of polycystic ovary syndrome (PCOS) usually spans a woman's reproductive years. While the treatment of symptoms is a primary concern, given its long-term nature, the benefits and potential risks need to be assessed and balanced. The variability of presentation coupled with the phenotypic diversity of this patient population, requires the individualization of treatment to each patient. Read More

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http://dx.doi.org/10.1586/17446651.3.3.349DOI Listing

Bone mineral density and vitamin D in PCOS and hirsutism.

Expert Rev Endocrinol Metab 2013 Sep;8(5):449-459

a Department of Endocrinology, Odense University Hospital, Sdr. Boulevard 29, 5000 Odense C, Denmark.

Polycystic ovary syndrome (PCOS) is the most frequent endocrinopathy in reproductive-aged women. The majority of hirsute patients are diagnosed with PCOS. Hyperandrogenemia, central obesity and insulin resistance may protect patients with PCOS from osteoporosis, whereas increased cortisol levels, low growth hormone and amenorrhea may be associated with decreased bone mineral density (BMD). Read More

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http://dx.doi.org/10.1586/17446651.2013.827384DOI Listing
September 2013

Divergences in insulin resistance between the different phenotypes of the polycystic ovary syndrome.

Expert Rev Endocrinol Metab 2013 Sep;8(5):427-429

b Institute of Reproductive and Developmental Biology (S.F.), Imperial College (Hammersmith Campus) London, W12 0NN, UK.

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http://dx.doi.org/10.1586/17446651.2013.827373DOI Listing
September 2013

Endocrinological insights into different in vitro fertilization treatment aspects.

Expert Rev Endocrinol Metab 2012 Jul;7(4):419-432

a Hammersmith Hospital, Du Cane Road, London, W12 0HS, UK.

The science of reproductive endocrinology/in vitro fertilization (IVF) has moved forward considerably since the first IVF baby was born in 1978. IVF was originally indicated for women with tubal factor infertility, but it has now become the treatment for couples with unexplained subfertility, male subfertility, cervical factor, failed ovulation induction, endometriosis or unilateral tubal pathology. IVF was initially performed with the single dominant ovarian follicle produced during a spontaneous menstrual cycle. Read More

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http://dx.doi.org/10.1586/eem.12.32DOI Listing

Ovarian surgery and follicular reserve.

Expert Rev Endocrinol Metab 2006 Nov;1(6):743-752

a Professor, University Hospitals Schleswig-Holstein, Campus Kiel, Department of Obstetrics and Gynecology, Michaelisstr. 16, 24105 Kiel, Germany.

In patients with cystic ovarian pathology, such as endometriomas, polycystic ovary syndrome, teratomas or benign tumors, there is a tendency towards abnormal ovarian function. Anovulation and sterility may occur. This review will summarize the normal physiology of the female gonad and the development of oogenesis from initial reproductive age to the menopause. Read More

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http://dx.doi.org/10.1586/17446651.1.6.743DOI Listing
November 2006
1 Read

Massive Ovarian Growth in a Severe Insulin-Resistant Polycystic Ovary Syndrome (PCOS) Woman Receiving GnRH-Analog.

J Clin Endocrinol Metab 2019 Feb 12. Epub 2019 Feb 12.

Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA.

Context: Ovarian hyperandrogenism from polycystic ovarian syndrome (PCOS) and hyperinsulinemia from insulin resistance are modulators of ovarian follicle development. We report a PCOS woman with hyperandrogenism and severe insulin resistance from metabolic syndrome who received long-term GnRH analog therapy preceding bilateral salpingo-oophorectomy for massive ovarian enlargement. Ovarian histological examination showed proliferating granulosa cells within antral follicles coexistent with serous cystadenofibromas, demonstrating a unique link between hyperinsulinemia and granulosa cell mitogenesis. Read More

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http://dx.doi.org/10.1210/jc.2018-02464DOI Listing
February 2019

Metabolic and hormonal effects of a combined Myo-inositol and d-chiro-inositol therapy on patients with polycystic ovary syndrome (PCOS).

Ginekol Pol 2019 ;90(1):7-10

Department of Obstetrics and Gynecology, Central Clinical Hospital of Interior, Warsaw, Poland.

Objectives: To evaluate the effects of a combined Myo-inositol (MI) and D-chiro-inositol (DCI) therapy on the hormonal and metabolic parameters of women with PCOS. Prospective clinical study. Clinical Study registration number - EUPAS25705 Material and methods: Seventy women diagnosed with PCOS according to the Rotterdam criteria were enrolled in this study. Read More

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http://dx.doi.org/10.5603/GP.2019.0002DOI Listing
January 2019
1 Read

An Unusual Presentation of Deep Vein Thrombosis.

Eur J Case Rep Intern Med 2018 28;5(8):000899. Epub 2018 Aug 28.

Department of Radiology, University Hospital Kerry, Tralee, Ireland.

May-Thurner syndrome (MTS) usually presents as acute or chronic deep vein thrombosis (DVT) in patients. A 49-year-old woman presented with left lower limb DVT, which was followed by a diagnosis of MTS on a background of polycystic ovary syndrome (PCOS) and hypothyroidism. MTS is more common among women in the second to fourth decades of life. Read More

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http://dx.doi.org/10.12890/2018_000899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346834PMC

Exercise, or exercise and diet for the management of polycystic ovary syndrome: a systematic review and meta-analysis.

Syst Rev 2019 Feb 12;8(1):51. Epub 2019 Feb 12.

Aston Medical Research Institute, Aston Medical School, Aston University, Birmingham, B4 7ET, UK.

Background: Typically, management of PCOS focuses on lifestyle changes (exercise and diet), aiming to alleviate symptoms, and lower the associated risk of type 2 diabetes and cardiovascular disease. Our objective was to analyse evidence on the effectiveness of exercise in the management of PCOS, when compared to (i) usual care, (ii) diet alone, and (iii) exercise combined with diet, and also exercise combined with diet, compared to (i) control or usual care and (ii) diet alone.

Methods: Relevant databases were searched (June 2017) with no time limit for trial inclusion. Read More

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http://dx.doi.org/10.1186/s13643-019-0962-3DOI Listing
February 2019

Should we use statins in treatment of polycystic ovary syndrome?

Expert Rev Endocrinol Metab 2009 May;4(3):209-211

b Department of Obstetrics and Gynecology, Poznan University of Medical Sciences, Polna 33, 60-535 Poznan, Poland.

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http://dx.doi.org/10.1586/eem.09.1DOI Listing

A unique androgen excess signature in idiopathic intracranial hypertension is linked to cerebrospinal fluid dynamics.

JCI Insight 2019 Feb 12. Epub 2019 Feb 12.

Idiopathic intracranial hypertension (IIH) is a condition of unknown etiology, characterized by elevated intracranial pressure frequently manifesting with chronic headaches and visual loss. Similar to polycystic ovary syndrome (PCOS), IIH predominantly affects obese women of reproductive age. In this study, we comprehensively examined the systemic and cerebrospinal fluid (CSF) androgen metabolome in women with IIH in comparison to sex-, body mass index- and age-matched control groups with either simple obesity and PCOS, i. Read More

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http://dx.doi.org/10.1172/jci.insight.125348DOI Listing
February 2019
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Amino acid and Fatty Acid Metabolomic Profile during Fasting and Hyperinsulinemia in girls with Polycystic Ovarian Syndrome.

Am J Physiol Endocrinol Metab 2019 Feb 12. Epub 2019 Feb 12.

Department of Pediatrics, Division of Pediatric Endocrinology, University of Colorado Anschutz. Center for Women's Health Research, Aurora, CO, United States.

Polycystic Ovarian Syndrome (PCOS) is associated with insulin resistance (IR) and altered muscle mitochondrial oxidative phosphorylation. IR in adults with obesity and diabetes is associated with changes in amino acid, free fatty acid (FFA) and mitochondrial acylcarnitine (AC) metabolism. We sought to determine if these metabolites are associated with IR and/or androgens in youth-onset PCOS. Read More

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http://dx.doi.org/10.1152/ajpendo.00532.2018DOI Listing
February 2019
2 Reads

Differential Expression Patterns of Glycolytic Enzymes and Mitochondria-Dependent Apoptosis in PCOS Patients with Endometrial Hyperplasia, an Early Hallmark of Endometrial Cancer, and the Impact of Metformin .

Int J Biol Sci 2019 24;15(3):714-725. Epub 2019 Jan 24.

Department of Physiology/Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, 40530 Gothenburg, Sweden.

The underlying mechanisms of polycystic ovarian syndrome (PCOS)-induced endometrial dysfunction are not fully understood, and although accumulating evidence shows that the use of metformin has beneficial effects in PCOS patients, the precise regulatory mechanisms of metformin on endometrial function under PCOS conditions have only been partially explored. To address these clinical challenges, this study aimed to assess the protein expression patterns of glycolytic enzymes, estrogen receptor (ER), and androgen receptor (AR) along with differences in mitochondria-dependent apoptosis in PCOS patients with and without endometrial hyperplasia and to investigate the effects of metformin in PCOS patients with endometrial hyperplasia . Here, we showed that compared to non-PCOS patients and PCOS patients without hyperplasia, the endometria from PCOS patients with hyperplasia had a distinct protein expression pattern of glycolytic enzymes, including pyruvate kinase isozyme M2 isoform (PKM2) and pyruvate dehydrogenase (PDH), and mitochondrial transcription factor A (TFAM). Read More

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http://dx.doi.org/10.7150/ijbs.31425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367580PMC
January 2019
2 Reads

Is ovarian volume a good predictor to determine metabolic syndrome development in polycystic ovary patients.

J Obstet Gynaecol 2019 Feb 11:1-5. Epub 2019 Feb 11.

c Department of Medical Biochemistry, Faculty of Medicine , Karadeniz Technical University , Trabzon , Turkey.

The aim of this study was to investigate the findings of ultrasound that could predict the metabolic syndrome (MetS) which may develop in polycystic ovary syndrome (PCOS) patients. A total of 96 consecutive PCOS patients, who were scheduled for any gynaecologic examination from January 2015 to January 2016 and who were eligible for the study, were prospectively enrolled in it. About 15. Read More

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https://www.tandfonline.com/doi/full/10.1080/01443615.2018.1
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http://dx.doi.org/10.1080/01443615.2018.1522530DOI Listing
February 2019
2 Reads

Genetic polymorphism of Methylenetetrahydrofolate reductase is associated with insulin resistance in Egyptian women with polycystic ovary syndrome.

J Gene Med 2019 Feb 11:e3076. Epub 2019 Feb 11.

Clinical Pathology Department, Faculty of Medicine, Zagazig University, Egypt.

Introduction: A common polymorphism (677C to T; Ala to Val) in the methylenetetrahydrofolate reductase (MTHFR) gene is associated with decreased specific MTHFR activity and elevation of the homocysteine.

Aim: to investigate the association between single nucleotide polymorphism (SNP) in MTHFR 677C>T gene and insulin resistance in women with polycystic ovary syndrome (PCOS). Subject& Methods Two-hundred patients with PCOS were included in this case- control study. Read More

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http://dx.doi.org/10.1002/jgm.3076DOI Listing
February 2019
1 Read

Zinc status and polycystic ovarian syndrome: A systematic review and meta-analysis.

J Trace Elem Med Biol 2019 Mar 4;52:216-221. Epub 2019 Jan 4.

Food Security Research Center, Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address:

Several studies have investigated serum zinc levels in patients with polycystic ovarian syndrome (PCOS), but the results of these studies remain inconclusive. Therefore, to derive a more precise estimation, we conducted a meta-analysis to investigate serum zinc concentrations in women with PCOS in comparison with healthy subjects. Electronic search was performed in PubMed, Scopus, and Google scholar up to April; 4, 2018 without any restriction. Read More

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http://dx.doi.org/10.1016/j.jtemb.2019.01.002DOI Listing
March 2019
1 Read

Perfluoroalkyl substances exposure and risk of polycystic ovarian syndrome related infertility in Chinese women.

Environ Pollut 2019 Jan 11;247:824-831. Epub 2019 Jan 11.

School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, PR China; MOE-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, PR China; The Ninth People's Hospital of Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, PR China. Electronic address:

Perfluoroalkyl substances (PFASs) are a family of synthetic, fluorinated organic compounds. They have been widely used in industrial applications and consumer products and widespread in the environment, wildlife and human. Experimental and epidemiologic evidence suggested that PFASs are capable of interfering with endocrine processes and have potential reproductive and developmental toxicities. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.01.039DOI Listing
January 2019
1 Read
4.143 Impact Factor

[Androgen-secreting tumours of the ovaries].

Ugeskr Laeger 2019 Feb;181(6)

The diagnosis of an androgen-secreting tumour of the ovaries should be considered in women with hyperandrogenism. Clinical manifestations of hyperandrogenism include virilisation with hirsutism, vocal change, increased muscle mass, hypertrophy of clitoris and alopecia. Definitive diagnosis is made by histopathologic examination, and the most common diagnoses are granulosa cell tumour, ovarian stromal hyperplasia and Sertoli-Leydig cell tumour. Read More

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February 2019
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Vaginal ultrasound-guided ovarian needle puncture compared to laparoscopic ovarian drilling in women with polycystic ovary syndrome.

Arch Gynecol Obstet 2019 Feb 6. Epub 2019 Feb 6.

Mc Gill Fertility Center, Department of Obstetrics and Gynecology, McGill University, Montreal, Canada.

Study Objective: To compare pregnancy outcomes in PCOS women undergoing transvaginal ovarian injury (TVOI) and laparoscopic ovarian drilling (LOD) DESIGN: 126 infertile patients with PCOS were included in this prospective cohort study CANADIAN TASK FORCE CLASSIFICATION OF LEVEL OF EVIDENCE: IIA.

Setting: University-affiliated fertility center.

Patients: Sixty-seven infertile patients with the history of failed in vitro maturation underwent follow-up as the TVOI group. Read More

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http://dx.doi.org/10.1007/s00404-019-05067-2DOI Listing
February 2019
1 Read

A Study on Omentin-1 and Prostate Specific Antigen in Women on Treatment for Polycystic Ovary Syndrome.

Indian J Clin Biochem 2019 Jan 11;34(1):108-114. Epub 2017 Dec 11.

2Department of Obstetrics and Gynecology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.

Omentin-1 and prostate specific antigen (PSA) are known to be markers of insulin resistance and hyperandrogenism respectively in polycystic ovary syndrome (PCOS). This study aimed to assess the changes in serum omentin-1 and PSA levels in PCOS patients while on treatment. Serum omentin-1, PSA, BMI and Ferriman gallwey score (FG score) were measured in 80 women with PCOS. Read More

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http://dx.doi.org/10.1007/s12291-017-0723-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346616PMC
January 2019
1 Read

Letrozole versus laparoscopic ovarian drilling in clomiphene citrate-resistant women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials.

Reprod Biol Endocrinol 2019 Feb 6;17(1):17. Epub 2019 Feb 6.

Family Planning Research Institute, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan, 430030, Hubei, China.

The objective of this systematic review was to examine the literature and to compare the effectiveness of letrozole (LE) versus laparoscopic ovarian drilling (LOD) for the induction of ovulation in women with clomiphene citrate (CC)-resistant polycystic ovary syndrome (PCOS). The PUBMED, Web of Science, and EMBASE databases were searched systematically for eligible randomized controlled trials (RCTs) from English language articles published from database inception to September 2018. Data were independently extracted and analyzed using the fixed-effects model or random-effects model according to the heterogeneity of the data. Read More

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http://dx.doi.org/10.1186/s12958-019-0461-3DOI Listing
February 2019
2 Reads
2.409 Impact Factor

Familial clustering of metabolic phenotype in brothers of women with polycystic ovary syndrome.

Gynecol Endocrinol 2019 Feb 6:1-3. Epub 2019 Feb 6.

a Department of Endocrinology , Sanjay Gandhi Post Graduate Institute of Medical Sciences , Lucknow , India.

Polycystic ovary syndrome (PCOS) is a complex polygenic endocrine disorder. Familial clustering of phenotype has been known and it endorses the heritability of the disease. Among brothers of women with PCOS, we found significantly higher waist circumference, elevated blood pressure and insulin resistance when compared with age and BMI matched controls. Read More

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http://dx.doi.org/10.1080/09513590.2019.1566451DOI Listing
February 2019
1 Read

Letrozole versus clomiphene in polycystic ovary syndrome-more than one way to crack an egg.

Fertil Steril 2019 Feb 2. Epub 2019 Feb 2.

University of Rochester Medical Center, Rochester, New York.

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http://dx.doi.org/10.1016/j.fertnstert.2018.12.020DOI Listing
February 2019
1 Read

Circulating leptin concentration, LEP gene variants and haplotypes, and polycystic ovary syndrome in Bahraini and Tunisian Arab women.

Gene 2019 Feb 2;694:19-25. Epub 2019 Feb 2.

Faculty of Sciences, El Manar University, Tunis, Tunisia; School of Medicine, Nazarbayev University, Astana, Kazakhstan. Electronic address:

Background And Aim: Epidemiological studies suggested that ethnic/racial background influences the associations of altered leptin secretion and leptin gene (LEP) polymorphisms with polycystic ovary syndrome (PCOS). We investigated the association between LEP variants and plasma leptin levels with PCOS in Tunisian and Bahraini Arab women.

Subjects And Methods: Retrospective case-control study, involving 255 PCOS cases and 253 control subjects from Bahrain, and 320 women PCOS cases and 447 controls from Tunisia. Read More

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http://dx.doi.org/10.1016/j.gene.2019.01.032DOI Listing
February 2019
1 Read
2.138 Impact Factor

Metformin induced First-Episode Psychosis on Patient with Polycystic Ovarian Syndrome Using Drospirenone.

Psychiatry Clin Neurosci 2019 Feb 4. Epub 2019 Feb 4.

Department of Psychiatry, Mackay Memorial Hospital, Taipei, Taiwan.

Polycystic ovary syndrome (PCOS) is commonly seen endocrine disorder affecting 5-15% of reproductive-aged women. Oral contraceptive pill (drospirenone) to improve menstrual cycle regularity and so called metformin to lower body mass index (BMI) were two common medication for treatment of PCOS. Here we detail a first-episode psychosis after taking drospirenone and metformin on female with polyctstic ovarian syndrome and further discuss the possible mechanism. Read More

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http://dx.doi.org/10.1111/pcn.12825DOI Listing
February 2019
1 Read

Association of rs6259 polymorphism with SHBG levels and Poly Cystic Ovary Syndrome in Indian population: a case control study.

Mol Biol Rep 2019 Feb 4. Epub 2019 Feb 4.

Centre for Medical Biotechnology, Maharshi Dayanand University, Rohtak, 124001, India.

Polycystic ovary syndrome (PCOS) is the most common endocrinopathy of reproductive-aged women. PCOS reflects a number of possible etiologies but its pathophysiology is still unclear. The principal abnormality of the syndrome is hyperandrogenism (70-80%). Read More

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http://dx.doi.org/10.1007/s11033-019-04665-2DOI Listing
February 2019
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Age at adiposity rebound in childhood is associated with PCOS diagnosis and obesity in adulthood-longitudinal analysis of BMI data from birth to age 46 in cases of PCOS.

Int J Obes (Lond) 2019 Feb 4. Epub 2019 Feb 4.

Department of Obstetrics and Gynaecology, PEDEGO Research Unit, Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland.

Background: Adiposity rebound (AR), the second BMI rise in childhood at around the age of 6 years, is associated with obesity and metabolic alteration in later life. Given that polycystic ovary syndrome (PCOS) has a strong metabolic component, early life growth patterns could reveal a risk of PCOS. Thus, we aimed to investigate the associations between age at AR and PCOS diagnosis and BMI later in life. Read More

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http://dx.doi.org/10.1038/s41366-019-0318-zDOI Listing
February 2019
2 Reads

MiR-222 promotes the progression of polycystic ovary syndrome by targeting p27 Kip1.

Pathol Res Pract 2019 Jan 28. Epub 2019 Jan 28.

Department of Reproductive Center, The Second Affiliated Hospital of Fujian Medical University, Quanzhou City, Fujian Province, 362000, PR China.

Polycystic ovary syndrome (PCOS) is one of the most complex and common reproductive and endocrinologic disorders in the child-bearing age of women. Recently, miR-222 were reported to be associated with the etiology of PCOS. However, the function of miR-222 during the pathogenesis of PCOS remains unclear. Read More

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http://dx.doi.org/10.1016/j.prp.2019.01.038DOI Listing
January 2019
1 Read

Syzygium cumini (L.) Skeels improves metabolic and ovarian parameters in female obese rats with malfunctioning hypothalamus-pituitary-gonadal axis.

J Ovarian Res 2019 Feb 4;12(1):13. Epub 2019 Feb 4.

Departamento de Ciências Fisiológicas, Universidade Federal do Maranhão, São Luís, Maranhão, Brazil.

Background: Obesity is a chronic and multifactorial disease characterized by increased adipose tissue. In females, obesity leads to reduced ovulation and lower chances of conception in diseases like polycystic ovary syndrome, making it important to characterize complementary medicine to attenuate such deleterious effects. Therefore, the aim of this study was to assess the effects of a hydroethanolic extract from Syzigium cumini leaves in female reproductive impairments present in the obesity model of neonatal L-monosodium glutamate injection. Read More

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https://ovarianresearch.biomedcentral.com/articles/10.1186/s
Publisher Site
http://dx.doi.org/10.1186/s13048-019-0490-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360653PMC
February 2019
2 Reads

The Prevalence of Metabolic Syndrome in the Different Phenotypes of Polycystic Ovarian Syndrome.

Rev Bras Ginecol Obstet 2019 Jan 4;41(1):37-43. Epub 2019 Feb 4.

Universidade Federal de Pernambuco, Recife, PE, Brazil.

Objective:  To evaluate the prevalence of metabolic syndrome (MetS) in the phenotypes of polycystic ovarian syndrome (PCOS).

Methods:  This was a cross-sectional study involving 111 women aged between 18 and 39 years old diagnosed with PCOS, according to the Rotterdam Criteria, and grouped into four phenotypes: A: ovulatory dysfunction + hyperandrogenism + polycystic ovaries; B: ovulatory dysfunction + hyperandrogenism; C: hyperandrogenism + polycystic ovaries; D: ovulatory dysfunction + polycystic ovaries. To evaluate the presence of MetS, we measured serum triglyceride levels, HDL cholesterol, fasting blood glucose, blood pressure, and waist circumference. Read More

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http://dx.doi.org/10.1055/s-0038-1676568DOI Listing
January 2019
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The Possibilities of Using Chromium Salts as an Agent Supporting Treatment of Polycystic Ovary Syndrome.

Biol Trace Elem Res 2019 Feb 4. Epub 2019 Feb 4.

Department of Pharmacobiology, Jagiellonian University Medical College, Kraków, Poland.

The polycystic ovary syndrome (PCOS) is the most frequent endocrinopathy in women in reproductive age with the so far undetermined causes of development. In the etiopathogenesis of PCOS, the role of insulin resistance is emphasised, which was an indication for the attempts at using chromium III salts (Cr) in augmenting pharmacotherapy applied in patients. The analysis of the usefulness and efficacy of this approach was the direct goal of this thesis. Read More

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http://dx.doi.org/10.1007/s12011-019-1654-5DOI Listing
February 2019
1 Read

Association of interleukin 17 polymorphisms with polycystic ovary syndrome.

J Obstet Gynaecol 2019 Feb 3:1-2. Epub 2019 Feb 3.

a Department of Clinical Analysis and Biomedicine , Post Graduation Program in Biosciences and Phisiophatology, State University of Maringá , Maringá , Brazil.

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http://dx.doi.org/10.1080/01443615.2018.1527299DOI Listing
February 2019
1 Read

Implications and Future Perspectives of AGEs in PCOS Pathophysiology.

Trends Endocrinol Metab 2019 Jan 31. Epub 2019 Jan 31.

Medical School, University of Athens, 11527 Goudi, Athens, Greece; Endocrinology and Diabetes Department, Hygeia Hospital, 15123 Marousi, Athens, Greece.

Human, animal, and in vitro studies provide evidence that advanced glycation end-products (AGEs) may contribute to the pathogenesis of polycystic ovary syndrome (PCOS) and its metabolic and reproductive consequences. AGEs are able to induce, via activation of key intracellular signaling pathways, the generation of oxidative stress and proinflammatory cytokines, thus contributing to the adverse health impact of PCOS. This review presents the implications of AGEs in several disease pathophysiologies, including PCOS, as well as the cellular and systemic effects of AGEs on insulin resistance (IR), hyperandrogenemia, endoplasmic reticulum (ER) stress, hypoxia, and ovarian function. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10432760193001
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http://dx.doi.org/10.1016/j.tem.2019.01.005DOI Listing
January 2019
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Comprehensive Evaluation of Type 2 Diabetes and Cardiovascular Disease Risk Profiles in Reproductive-Age Women with Polycystic Ovary Syndrome: A Large Canadian Cohort.

J Obstet Gynaecol Can 2019 Jan 31. Epub 2019 Jan 31.

Department of Obstetrics and Gynecology, College of Medicine, University of Saskatchewan, Saskatoon, SK. Electronic address:

Objective: This study compared the prevalence of metabolic syndrome (MetS) and characterized type 2 diabetes (DM2) and cardiovascular disease (CVD) risk profiles between Canadian women with polycystic ovary syndrome (PCOS) and healthy women recruited from the general population. Furthermore, within the PCOS cohort, the study contrasted the CVD and DM2 risk profiles of women with or without MetS.

Methods: Measures of MetS (International Diabetes Federation; National Heart, Lung, and Blood Institute; and the American Heart Association definition), DM2 (Diabetes Canada Clinical Guidelines), and CVD risk factors (Androgen Excess and Polycystic Ovary Syndrome Society statement) were evaluated for 237 women with PCOS (Androgen Excess and PCOS Society definitions) and 42 controls (aged 18-36) in a prospective observational study (Canadian Task Force classification II-2). Read More

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http://dx.doi.org/10.1016/j.jogc.2018.11.026DOI Listing
January 2019
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Gremlin-1 and gremlin-2 levels in polycystic ovary syndrome and their clinical correlations.

Gynecol Endocrinol 2019 Feb 4:1-4. Epub 2019 Feb 4.

a Department of Obstetrics and Gynecology , Health Sciences University Kanuni Sultan Suleyman Training and Research Hospital , Istanbul , Turkey.

Objective: Gremlin 1 and 2 regulate oocyte primordial follicle transition in animal models. The main objective of this study is to measure the blood levels of Gremlin 1 and 2 in the women with Polycystic Ovary Syndrome (PCOS). We also aimed to evaluate the association of these markers with hormonal and biochemical parameters of PCOS as interrupted folliculogenesis in those women is related to metabolic dysfunction. Read More

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http://dx.doi.org/10.1080/09513590.2019.1566452DOI Listing
February 2019
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Temperament and character differences of patients with polycystic ovary syndrome.

J Gynecol Obstet Hum Reprod 2019 Jan 31. Epub 2019 Jan 31.

Adnan Menderes Boulevard (Vatan Road) Fatih, İstanbul, 34093, Turkey; Bezmialem Foundation University Medical Faculty, Department of Psychiatry, Turkey.

Aim: There is an unclear relationship between Polycystic Ovary Syndrome and psychiatric disorders including anxiety and depression. We aimed to evaluate temperamental and personal characteristics of patients with PCOS.

Methods: Fifty patients with PCOS and 41 healthy controls were included in the study. Read More

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http://dx.doi.org/10.1016/j.jogoh.2019.01.006DOI Listing
January 2019
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Live birth rates with a freeze-only strategy versus fresh embryo transfer: secondary analysis of a randomized clinical trial.

Reprod Biomed Online 2018 Dec 21. Epub 2018 Dec 21.

Department of Obstetrics and Gynaecology, School of Medicine, Monash University, Melbourne, Australia.

Research Question: What are the roles of serum progesterone and endometrial thickness as biomarkers in the decision between a freeze-only and fresh embryo transfer in IVF for women without polycystic ovary syndrome (PCOS)?

Design: This was a secondary analysis of a randomized controlled trial including 782 couples who were followed up until the end of the first completed cycle. Couples scheduled for their first or second IVF cycle with a FSH/gonadotrophin-releasing hormone antagonist protocol were randomized to a freeze-only (n = 391) or fresh embryo transfer (n = 391) strategy. The endpoint for this analysis was live birth rate (LBR) after the first embryo transfer. Read More

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http://dx.doi.org/10.1016/j.rbmo.2018.12.012DOI Listing
December 2018
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Metabolic syndrome in adolescents with polycystic ovary syndrome: prevalence based on different diagnostic criteria.

J Pediatr Adolesc Gynecol 2019 Jan 30. Epub 2019 Jan 30.

Nationwide Children's Hospital, Division of Adolescent Medicine, 700 Children's Drive, Suite LA3A, Columbus, Ohio, USA 43205.

Study Objective: Existing literature on the prevalence of metabolic syndrome (MBS) in adolescents with polycystic ovary syndrome (PCOS) is inconsistent, likely due to the application of differing diagnostic criteria. The objective was to assess the prevalence of MBS in adolescents with PCOS depending on the PCOS diagnostic criteria utilized.

Design, Setting, And Participants: A retrospective chart review of female patients (N=37), ages 11-22 years, diagnosed with PCOS between 01/2013-12/2017. Read More

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http://dx.doi.org/10.1016/j.jpag.2019.01.006DOI Listing
January 2019
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Diagnosis of disorders of glucose tolerance in women with polycystic ovary syndrome (PCOS) at a tertiary care center: fasting plasma glucose or oral glucose tolerance test?

Metabolism 2019 Jan 30. Epub 2019 Jan 30.

Diabetes, Obesity and Hum Reprod Research Group, Department of Endocrinology & Nutrition, Hospital Universitario Ramón y Cajal & Universidad de Alcalá & Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS) & Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, 28034, Spain. Electronic address:

Background: The risk of developing prediabetes and type 2 diabetes (dysglycemia) may be increased in women with PCOS. Whether an oral glucose tolerance test (OGTT) should be performed routinely in all PCOS women at presentation or should be recommended only to a selected subset of patients is still controversial.

Basic Procedures: At a tertiary care center, we conducted a retrospective, observational study including 400 women with PCOS submitted to an OGTT. Read More

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http://dx.doi.org/10.1016/j.metabol.2019.01.015DOI Listing
January 2019
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Association between CD16 monocytes in peripheral blood and clinical features and short-term therapeutic effects of polycystic ovary syndrome.

Int J Gynaecol Obstet 2019 Feb 2. Epub 2019 Feb 2.

Laboratory for Reproductive Immunology, Hospital and Institute of Obstetrics and Gynecology, Shanghai Medical School, Fudan University, Shanghai, China.

Objective: To evaluate the association between CD16 monocytes in peripheral blood and the clinical features and short-term therapeutic effects of polycystic ovary syndrome (PCOS).

Methods: This prospective cross-sectional study included women diagnosed with PCOS at a university hospital in Shanghai, China, between June 4 and November 28, 2016. Patients received Diane-35, metformin, or both combined for 3 months. Read More

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http://dx.doi.org/10.1002/ijgo.12779DOI Listing
February 2019
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Immunophenotypic profile of leukocytes in hyperandrogenemic female rat an animal model of polycystic ovary syndrome.

Life Sci 2019 Mar 29;220:44-49. Epub 2019 Jan 29.

Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, United States of America; Women's Health Research Center, University of Mississippi Medical Center, United States of America. Electronic address:

The immune etiology of polycystic ovary syndrome (PCOS) is an intriguing area. However, whether there is alteration in the leukocyte populations in different tissues remain ambiguous.

Aim: To characterize the leukocyte populations of hyperandrogenemic female (HAF) rat tissues. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.01.048DOI Listing
March 2019
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Why Polycystic Ovary Syndrome (PCOS) needs long-term management?

Curr Pharm Des 2019 Jan 29. Epub 2019 Jan 29.

Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing. China.

Background: Polycystic ovary syndrome (PCOS) is a frequent female reproductive endocrine disease. It has been associated with numerous severe reproductive and metabolic abnormalities. However, there are still open questions especially regarding the best long-term management. Read More

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http://www.eurekaselect.com/169465/article
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http://dx.doi.org/10.2174/1381612825666190130104922DOI Listing
January 2019
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Relationship between Hypothyroidism and Endometrial Cancer.

Aging Dis 2019 Feb 1;10(1):190-196. Epub 2019 Feb 1.

Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing, China.

Thyroid dysfunction is involved in several types of carcinoma. Hypothyroidism is one of the most common medical morbidities among patients with endometrial cancer; however, the related mechanism is unclear. Among the risk factors related to endometrial cancer, hypothyroidism interacts with metabolic syndrome, polycystic ovarian syndrome and infertility or directly acts on the endometrium itself, which may influence the development and progression of endometrial cancer. Read More

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http://dx.doi.org/10.14336/AD.2018.0224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345335PMC
February 2019
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The Impact of Obesity on the Incidence of Type 2 Diabetes Among Women With Polycystic Ovary Syndrome.

Diabetes Care 2019 Jan 31. Epub 2019 Jan 31.

Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Clayton, Victoria, Australia

Objective: The nature of the independent relationship between polycystic ovary syndrome (PCOS) and type 2 diabetes remains unclear. Few studies have aimed to clarify this relationship independent of obesity in longitudinal population-based cohorts.

Research Design And Methods: We used the Australian Longitudinal Study on Women's Health (ALSWH) (2000-2015) database to estimate nationwide incidence rates and predictors of type 2 diabetes among women aged 18-42 using person-time and survival analysis. Read More

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http://dx.doi.org/10.2337/dc18-1738DOI Listing
January 2019
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Metformin use in polycystic ovary syndrome pregnancy impacts on offspring obesity.

Authors:
David H Abbott

Lancet Child Adolesc Health 2019 Jan 28. Epub 2019 Jan 28.

Department of Obstetrics and Gynecology, Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S23524642193000
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http://dx.doi.org/10.1016/S2352-4642(19)30001-XDOI Listing
January 2019
5 Reads