17,781 results match your criteria Polycystic Ovarian Disease Stein-Leventhal Syndrome


Transmission of polycystic ovary syndrome susceptibility single-nucleotide polymorphisms and their association with phenotype changes in offspring.

Hum Reprod 2020 Jul 3. Epub 2020 Jul 3.

Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China.

Study Question: Does the inheritance of polycystic ovary syndrome (PCOS) susceptibility single-nucleotide polymorphism affect the phenotype of offspring?

Summary Answer: Male offspring who inherit PCOS-related genetic variations from PCOS mothers were more susceptible to developing the metabolic abnormality in their later life.

What Is Known Already: Genetic factors are considered the major etiology of PCOS. Previous studies have highlighted that offspring of women with PCOS had an increased risk of the same disease or PCOS-like symptoms. Read More

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http://dx.doi.org/10.1093/humrep/deaa125DOI Listing

Pathophysiological roles of chronic low-grade inflammation mediators in polycystic ovary syndrome.

J Cell Physiol 2020 Jul 2. Epub 2020 Jul 2.

Infertility and Reproductive Health Research Center, Health Research Institute, Babol University of Medical Science, Babol, Iran.

Polycystic ovary syndrome (PCOS) is the most common hormonal imbalance disease in reproductive-aged women. Its basic characteristics are ovulatory dysfunction and ovarian overproduction of androgens that lead to severe symptoms such as insulin resistance, hirsutism, infertility, and acne. Notwithstanding the disease burden, its underlying mechanisms remain unknown, and no causal therapeutic exists. Read More

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http://dx.doi.org/10.1002/jcp.29912DOI Listing

Hashimoto's thyroiditis might increase polycystic ovary syndrome and associated comorbidities risks in Asia.

Ann Transl Med 2020 Jun;8(11):684

Graduate Institute of Biomedical Sciences, China Medical University, Taichung.

Background: To investigate whether increased the comorbidities such as coronary artery disease (CAD) and risks between Hashimoto's thyroiditis (HT) and polycystic ovary syndrome (PCOS) in Taiwanese women.

Methods: Patients newly diagnosed as having HT during 2000-2012 were assigned to the case group. Cases and controls were matched for age and comorbidities at a 1:2 ratio using propensity score matching. Read More

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http://dx.doi.org/10.21037/atm-19-4763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327368PMC

Response Comment on "Association between Interleukin-32 and Interleukin-17A Single Nucleotide Polymorphisms and Serum Levels with Polycystic Ovary Syndrome".

Iran J Allergy Asthma Immunol 2020 Jun 23;19(3):320-322. Epub 2020 Jun 23.

Department of Immunology, Shiraz University of Medical Sciences, Shiraz, Iran AND Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

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http://dx.doi.org/10.18502/ijaai.v19i3.3462DOI Listing

Comment on "Association between Interleukin-32 and Interleukin-17A Single Nucleotide Polymorphisms and Serum Levels with Polycystic Ovary Syndrome".

Iran J Allergy Asthma Immunol 2020 Feb 13;19(3):318-319. Epub 2020 Feb 13.

Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.

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http://dx.doi.org/10.18502/ijaai.v19i3.3461DOI Listing
February 2020

Perspectives on the International Recommendations for the Diagnosis and Treatment of Polycystic Ovary Syndrome in Adolescence.

J Pediatr Adolesc Gynecol 2020 Jun 29. Epub 2020 Jun 29.

, The University of Chicago Pritzker School of Medicine, Section of Adult and Pediatric Endocrinology, Diabetes, and Metabolism, 5841 S. Maryland Avenue (MC-5053), Chicago, IL 60637-1470 USA. Electronic address:

Three international conferences 2015-2018 have provided recommendations for the diagnosis and treatment of polycystic ovary syndrome (PCOS) in adolescence. In spite of agreement about essentials, differences among details of these recommendations have engendered confusion. This Commentary provides perspective about the agreements and disagreements among these recommendations and how these recommendations relate to other guidance. Read More

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http://dx.doi.org/10.1016/j.jpag.2020.06.017DOI Listing

Osteosarcopenia in reproductive-aged women with polycystic ovary syndrome: a multicenter case-control study.

J Clin Endocrinol Metab 2020 Jul 2. Epub 2020 Jul 2.

Division of Nutritional Sciences, Human Metabolic Research Unit, Cornell University, Ithaca, NY, USA.

Context: Osteosarcopenia (loss of skeletal muscle and bone mass and/or function usually associated with aging) shares pathophysiological mechanisms with polycystic ovary syndrome (PCOS). However, the relationship between osteosarcopenia and PCOS remains unclear.

Objective: We evaluated skeletal muscle index% (SMI%=[appendicular muscle mass/weight {kg}]×100) and bone mineral density (BMD) in PCOS (hyperandrogenism+oligoamenorrhea), and contrasted these musculoskeletal markers against 3 reproductive phenotypes: (1) HA (hyperandrogenism+eumenorrhea); (2) OA (normoandrogenic+oligoamenorrhea) and, (3) controls (normoandrogenic+eumenorrhea). Read More

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http://dx.doi.org/10.1210/clinem/dgaa426DOI Listing

Subfatin and asprosin, two new metabolic players of polycystic ovary syndrome.

J Obstet Gynaecol 2020 Jul 1:1-6. Epub 2020 Jul 1.

Department of Medical Biochemistry and Clinical Biochemistry (Firat Hormones Research Group), School of Medicine, Firat University, Elazig, Turkey.

Asprosin and subfatin are recently discovered two new hormones of adipocyte origin that play a role in the regulation of glucose metabolism. Polycystic ovary syndrome (PCOS) is a gynaecological syndrome presenting with energy turbulence. The aim of this study was to investigate whether asprosin and subfatin play a role in PCOS disease. Read More

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http://dx.doi.org/10.1080/01443615.2020.1758926DOI Listing

Indicator of early kidney injury in adolescents with polycystic ovary syndrome: Can urine NGAL level be?

Gynecol Endocrinol 2020 Jul 1:1-4. Epub 2020 Jul 1.

Medical Faculty, Department of Pediatric Hematology, Yuzuncu Yil University, Van, Turkey.

The Urinary Neutrophil-gelatinase associated lipocalin (NGAL) levels which are a biomarker for early diagnosis of kidney damage that may develop in patients with Polycystic Ovary Syndrome (PCOS) were investigated in the study. The 30 patients diagnosed with Polycystic Ovarian Syndrome between the ages of 13 and 18 who applied to the Yuzuncu Yil University General Children's Outpatient Clinic were included in the PCOS group and 30 healthy adolescents without any known acute or chronic illness and drug use were included in the control group. Urine NGAL value was 842. Read More

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http://dx.doi.org/10.1080/09513590.2020.1787377DOI Listing

Involvement of ACE2/Ang-(1-7)/MAS1 Axis in the Regulation of Ovarian Function in Mammals.

Authors:
Kamila Domińska

Int J Mol Sci 2020 Jun 27;21(13). Epub 2020 Jun 27.

Medical University of Lodz, Department of Comparative Endocrinology, Zeligowskiego 7/9, 90-752 Lodz, Poland.

In addition to the classic, endocrine renin-angiotensin system, local renin-angiotensin system (RAS) has been documented in many tissues and organs, including the ovaries. The localization and functional activity of the two opposing axes of the system, viz. ACE1/Ang II/AT1 and ACE2/Ang-(1-7)/MAS1, differs between animal species and varied according to the stage of follicle development. Read More

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http://dx.doi.org/10.3390/ijms21134572DOI Listing

A Cross-Sectional Investigation of Quality of Life in Patients with Polycystic Ovary Syndrome.

Sisli Etfal Hastan Tip Bul 2018 21;52(2):109-113. Epub 2018 May 21.

Department of Psychiatry, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey.

Objectives: The aim of this study is to investigate the effect of physical signs and comorbid psychopathology on quality of life in women with polycystic ovary syndrome (PCOS).

Methods: This cross-sectional study was conducted to assess 84 women with PCOS according to Rotterdam diagnosis criteria. Structured Clinical Interview for DSM-IV Axis 1 Disorders (SCID-I) and the World Health Organization Quality of Life-Brief Form (WHOQOL-BREF) were applied to each participant. Read More

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http://dx.doi.org/10.14744/SEMB.2018.38247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315064PMC

Live birth after a freeze-only strategy versus fresh embryo transfer in three randomized trials considering progesterone concentration.

Reprod Biomed Online 2020 May 14. Epub 2020 May 14.

Department of Obstetrics and Gynecology, Penn State College of Medicine, Hershey PA 17033, USA.

Research Question: Is there a difference in live birth rate between a freeze-only strategy and fresh embryo transfer, and what is the effect of varying progesterone concentrations on the day of human chorionic gonadotrophin (HCG) administration?

Design: A secondary analysis of data from three randomized trials comparing the live birth rate after elective frozen versus fresh embryo transfer, which respectively enrolled 1508 women with polycystic ovary syndrome, 2157 ovulatory women who underwent cleavage-stage embryo transfer and 1650 ovulatory women who underwent single blastocyst transfer. Women were randomly assigned to the frozen or fresh embryo transfer group in the original trials. The primary outcome was live birth rate after the initial embryo transfer. Read More

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http://dx.doi.org/10.1016/j.rbmo.2020.04.021DOI Listing

Hormones and Thrombosis: Risk Across the Reproductive Years and Beyond.

Transl Res 2020 Jun 26. Epub 2020 Jun 26.

Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh Medical Center, Pittsburgh Pennsylvania, Pittsburgh, Pennsylvania, USA; Hemophilia Center of Western Pennsylvania, Pittsburgh, Pennsylvania, USA. Electronic address:

Endogenous and exogenous hormones have significant effects on coagulation and may tip the hemostatic balance toward thrombosis. The endogenous hormonal changes in pregnancy and polycystic ovary syndrome, and exogenous hormonal contraception, menopause replacement, and transgender cross-hormone replacement may increase thromboembolism risk. Using the lowest effective dose is critical for prevention, but once thrombosis occurs, anticoagulation may be required, in some, long-term. Read More

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http://dx.doi.org/10.1016/j.trsl.2020.06.011DOI Listing

The insulin signaling pathway is dysregulated in cumulus cells from obese, infertile women with polycystic ovarian syndrome with an absence of clinical insulin resistance.

Ther Adv Reprod Health 2020 Jan-Dec;14:2633494120906866. Epub 2020 Jun 17.

Gynecology Endocrinology Discipline, Gynecology Department, Escola Paulista de Medicina da Universidade Federal de Sao Paulo (UNIFESP-EPM), São Paulo, Brazil.

Methods: This is a cohort study, conducted at a university-based reproductive medicine center and private reproductive medicine center that aimed to evaluate granulosa cumulus cell gene expression in the insulin signaling pathway in Polycystic Ovary Syndrome (PCOS) patients undergoing in vitro fertilization (IVF) treatment and to compare the cumulus gene expression between normal weight and obese women without clinical insulin resistance. Fifteen PCOS patients, nine normal weight patients and six obese patients presenting normal HOMA IR (Homeostasis Model Assessment-Insulin Resistance), participated. Patients underwent oocyte retrieval for IVF and after the procedure, granulosa cumulus cells were removed from the oocytes for RNA extraction. Read More

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http://dx.doi.org/10.1177/2633494120906866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303777PMC

Analysis of 52 C and C steroids by UPC-MS/MS: Characterising the C11-oxy steroid metabolome in serum.

J Chromatogr B Analyt Technol Biomed Life Sci 2020 Jun 13;1152:122243. Epub 2020 Jun 13.

Department of Biochemistry, Stellenbosch University, Stellenbosch, South Africa. Electronic address:

The C11-oxy androgens have been implicated in the progression of many diseases and endocrine-linked disorders, such as polycystic ovarian syndrome (PCOS), congenital adrenal hyperplasia, specifically 21-hydroxylase deficiency (21OHD), castration resistant prostate cancer (CRPC), as well as premature adrenarche. While the C11-oxy C steroids have been firmly established in the steroid arena, the C11-oxy C steroids are now also of significance. The current study reports on a high-throughput ultra-performance convergence chromatography tandem mass spectrometry (UPC-MS/MS) method for the separation and quantification of 52 steroids in peripheral serum, which include the C11-oxy C and C11-oxy C steroids. Read More

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http://dx.doi.org/10.1016/j.jchromb.2020.122243DOI Listing

Good agreement between hyperinsulinemic-euglycemic clamp and 2h oral minimal model assessed insulin sensitivity in adolescents.

Pediatr Diabetes 2020 Jun 26. Epub 2020 Jun 26.

Department of Pediatrics, Division of Pediatric Endocrinology, University of Colorado Anschutz Medical Campus, Aurora, CO.

Background/objective: Rates of dysglycemia are increasing in youth, secondary to obesity and decreased insulin sensitivity (IS) in puberty. The Oral Minimal Model (OMM) has been developed in order to measure insulin sensitivity using an easy oral glucose load such as an oral glucose tolerance test (OGTT), instead of an hyperinsulinemic-euglycemic clamp (HE-Clamp), a more invasive and time-consuming procedure. However, this model, following a standard 2h- OGTT has never been validated in youth, a population known for a different physiologic response to OGTT than adults. Read More

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http://dx.doi.org/10.1111/pedi.13072DOI Listing

Plasma sclerostin levels are associated with nutritional status and insulin resistance but not hormonal disturbances in women with polycystic ovary syndrome.

Arch Gynecol Obstet 2020 Jun 26. Epub 2020 Jun 26.

Health Promotion and Obesity Management Unit, Department of Pathophysiology, Medical Faculty in Katowice, The Medical University of Silesia, Medyków 18, 40-752, Katowice, Poland.

Objective: The aim of this study was to evaluate the circulating sclerostin levels with nutritional status, insulin resistance and hormonal disturbances in women with polycystic ovary syndrome (PCOS).

Patients And Methods: The cross-sectional study involved 98 PCOS inpatients (20 normal weight, 17 overweight and 61 obese) with stable body mass. Body composition was assessed by bioimpedance method in addition to anthropometric measurements (body mass and height). Read More

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http://dx.doi.org/10.1007/s00404-020-05656-6DOI Listing

Relationship between the characteristic traits of polycystic ovary syndrome and susceptibility genes.

Sci Rep 2020 Jun 26;10(1):10479. Epub 2020 Jun 26.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul, South Korea.

Polycystic ovary syndrome (PCOS) is a highly complex disorder influenced by genetic and environmental factors. Previous genome-wide association studies (GWAS) on Han Chinese, Korean, and European populations identified multiple PCOS-susceptible loci; however, only a few studies reported the association of susceptibility genes with disease phenotypic traits. This cross-sectional study aimed to investigate the association between PCOS susceptibility genes from GWAS and disease-related clinical features. Read More

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http://dx.doi.org/10.1038/s41598-020-66633-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320020PMC

Nanocurcumin alleviates insulin resistance and pancreatic deficits in polycystic ovary syndrome rats: Insights on PI3K/AkT/mTOR and TNF-α modulations.

Life Sci 2020 Jun 23;256:118003. Epub 2020 Jun 23.

Molecular Biology and Medical Biochemistry Department, Faculty of Medicine, Cairo University, Cairo, Egypt.

Introduction And Aims: Polycystic ovary syndrome (PCOS) is a widespread endocrine disorder affecting females. Mechanisms underlying PCOS complicated pathology remain largely unknown, making current treatment only symptomatic. Increasing reports suggest impaired PI3K/AKT/mTOR pathway and tumor necrosis factor-α (TNF-α) levels are involved in cellular proliferation and metabolism-related disorders. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.118003DOI Listing

Association of the Genetic Polymorphisms rs6259 and rs727428 of the Gene with Polycystic Ovary Syndrome Risk: A Meta-Analysis.

Genet Test Mol Biomarkers 2020 Jun 24. Epub 2020 Jun 24.

Department of Obstetrics and Gynecology, Shanghai Songjiang District Central Hospital, Shanghai, China.

Studies investigating the relationship between polymorphisms of the sex hormone-binding globulin () gene and polycystic ovary syndrome (PCOS) have reported differing results. Therefore, the present meta-analysis was performed to clarify the effects of the and polymorphisms on PCOS risk. Published English language studies were selected through an extensive search of the Web of Science, PubMed, and EMBASE databases. Read More

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http://dx.doi.org/10.1089/gtmb.2019.0229DOI Listing

Adiponectin Reduces Embryonic Loss Rate and Ameliorates Trophoblast Apoptosis in Early Pregnancy of Mice with Polycystic Ovary Syndrome by Affecting the AMPK/PI3K/Akt/FoxO3a Signaling Pathway.

Reprod Sci 2020 Jun 25. Epub 2020 Jun 25.

Department of Reproductive Medicine, The First Affiliated Hospital, Jinan University, 601 West Huangpu Avenue, Guangzhou, 510000, Guangdong, People's Republic Of China.

Reports in recent years have suggested that adiponectin (APN) improves insulin resistance and inhibits apoptosis by activating the AMP-activated protein kinase (AMPK) pathway and the PI3K/Akt signaling pathway after binding to its receptor. This study aims to explore the mechanism by which APN reduces embryo loss rate and trophoblast apoptosis in early pregnancy of mice with polycystic ovary syndrome (PCOS). PCOS mice were subcutaneously injected with APN (10 μg mg kg day) on 11 consecutive days from the 3rd day of pregnancy onwards to observe the change of the embryo loss rate of PCOS mice induced by APN. Read More

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http://dx.doi.org/10.1007/s43032-020-00237-zDOI Listing

From Prediabetes to Type 2 Diabetes Mellitus in Women with Polycystic Ovary Syndrome: Lifestyle and Pharmacological Management.

Int J Endocrinol 2020 8;2020:6276187. Epub 2020 Jun 8.

Diabetes Unit, Niguarda Cà Granda Hospital, Milan, Italy.

Aims: Despite the very clear association between polycystic ovary syndrome (PCOS) and dysglycemia, few studies have explored the continuum of glycemic alterations leading from minor glucose abnormalities to overt diabetes. The purpose of this review is to trace the natural history of glycemic alteration in women with PCOS.

Methods: We performed a literature review without time limit until August 2019. Read More

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http://dx.doi.org/10.1155/2020/6276187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298266PMC

Polycystic Ovary Syndrome and Psychotic Disorder.

Front Psychiatry 2020 10;11:543. Epub 2020 Jun 10.

First Episode Psychosis Program, Department of Psychiatry, Universidade Federal de São Paulo (UNIFESP), Sao Paulo, Brazil.

Polycystic ovary syndrome (PCOS), a disease that usually emerges during adolescence, is characterized by hormonal imbalance and ovarian dysfunction. The prevalence can vary between 5.6 to 21. Read More

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http://dx.doi.org/10.3389/fpsyt.2020.00543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297942PMC

Increased oxidative stress is associated with thiol/disulphide homeostasis in clomiphene citrate resistant polycystic ovary syndrome.

J Obstet Gynaecol 2020 Jun 25:1-4. Epub 2020 Jun 25.

Department of Gynecology and Obstetrics, Gazi Yasargil Training and Research Hospital, Health Sciences University, Diyarbakır, Turkey.

The purpose of this study was to evaluate the relation CC resistant PCOS and the thiol/disulphide homeostasis, used as a marker of OS, by measuring that exchange using a novel technique. Sixty women patients admitted to the infertility clinic were evaluated. The patients were divided into two groups. Read More

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http://dx.doi.org/10.1080/01443615.2020.1786033DOI Listing

Is There a Bidirectional Association between Polycystic Ovarian Syndrome and Periodontitis? A Systematic Review and Meta-analysis.

J Clin Med 2020 Jun 23;9(6). Epub 2020 Jun 23.

Clinical Research Unit (CRU), Centro de Investigação Interdisciplinar Egas Moniz (CiiEM), Instituto Universitário Egas Moniz (IUEM), 2829-511 Caparica, Portugal.

Polycystic ovary syndrome (PCOS) has reproductive and metabolic properties that may be linked to periodontitis (PD). This study aimed to update and render a robust critical assessment on all evidence linking PCOS and PD, and appraising a hypothetical bidirectional association. Five databases (PubMed, Scholar, EMBASE, Web of Science and CENTRAL) were searched up to May 2020. Read More

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http://dx.doi.org/10.3390/jcm9061961DOI Listing

The impact of high-intensity interval training on inflammatory markers in metabolic disorders: A meta-analysis.

Scand J Med Sci Sports 2020 Jun 25. Epub 2020 Jun 25.

The Early Life Research Unit, Division of Child Health, Obstetrics and Gynaecology, and Nottingham Digestive Disease Centre and Biomedical Research Centre, School of Medicine, University of Nottingham, Nottingham, NG7 2UH, United Kingdom.

Introduction: High-intensity interval training (HIIT) is considered a time-efficient strategy to improve metabolic health. We performed a systematic meta-analysis to assess the effects of HIIT on inflammatory markers and adipo-cytokines compared with control conditions (CON) or moderate intensity continuous training (MICT) in individuals with metabolic disorders.

Methods: Up to January 2020, electronic databases were searched for HIIT interventions based on populations with metabolic disorders including diabetes, metabolic syndrome, polycystic ovary syndrome, non-alcoholic fatty liver disease or overweight/obesity, with outcome measurements that included IL-6, TNF-α, CRP, leptin or adiponectin and training ≥2 weeks. Read More

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http://dx.doi.org/10.1111/sms.13754DOI Listing

Luteinizing Hormone To Follicle Stimulating Hormone Ratio In Patients With Polycystic Ovary Syndrome.

J Ayub Med Coll Abbottabad 2020 Apr- Jun;32(2):255-258

Department of Physiology, Khyber Medical College, Peshawar, Pakistan.

Background: Polycystic ovary syndrome is the most commonly occurring endocrinopathy in females of reproductive age group. It is characterized by a wide range of signs and symptoms resulting from hormonal derangements leading to reduced fertility.

Methods: This was a crosssectional (comparative) study. Read More

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Liraglutide: New Perspectives for the Treatment of Polycystic Ovary Syndrome.

Clin Drug Investig 2020 Jun 24. Epub 2020 Jun 24.

Embryopulse Fetal Medicine Center, Paphos, Cyprus.

Polycystic ovary syndrome is a complex and heterogenous disorder involving multiple organ systems and different molecular pathways. It is tightly associated with obesity and especially abdominal obesity. As body weight reduction is the main modifiable risk factor for polycystic ovary syndrome, therapeutic approaches in overweight or obese women with polycystic ovary syndrome have been developed. Read More

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http://dx.doi.org/10.1007/s40261-020-00942-2DOI Listing

Association of genetic variations in phosphatase and tensin homolog (PTEN) gene with polycystic ovary syndrome in South Indian women: a case control study.

Arch Gynecol Obstet 2020 Jun 24. Epub 2020 Jun 24.

Department of Biochemistry, Osmania University, Hyderabad, 500 007, India.

Purpose: The purpose of the study was to investigate the association between gene phosphate and tensin homolog (PTEN) single nucleotide polymorphisms (SNPs) and risk of developing polycystic ovary syndrome (PCOS) in South Indian women. PTEN is one of the most important tumor suppressor genes that regulate cell proliferation, migration, and death. It is also involved in the maintenance of genome stability. Read More

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http://dx.doi.org/10.1007/s00404-020-05658-4DOI Listing

Polycystic Ovary Syndrome, Subfertility and Vitamin D Deficiency.

J Coll Physicians Surg Pak 2020 May;30(5):545-546

Department of Biological and Biomedical Sciences, The Aga khan university, Karachi, Pakistan.

Polycystic ovarian syndrome (PCOS) is the most common endocrine female disorder, affecting 4-18% women of reproductive age. The prevalence of PCOS in South Asian women, especially in Pakistani women, is much higher (52%) as compared to white population (20 - 25% in UK). In Pakistan, vitamin D status displays 31. Read More

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http://dx.doi.org/10.29271/jcpsp.2020.05.545DOI Listing

Risk of Psoriasis in Patients with Polycystic Ovary Syndrome: A National Population-Based Cohort Study.

J Clin Med 2020 Jun 22;9(6). Epub 2020 Jun 22.

Institute of Medicine, Chung Shan Medical University, Taichung 40203, Taiwan.

Both polycystic ovary syndrome (PCOS) and psoriasis are associated with insulin resistance and metabolic syndrome. Nonetheless, the incidence of psoriasis in patients with PCOS is unclear. We used the Longitudinal Health Insurance Research Database (LHID) in Taiwan from 2000 to 2012 to perform a retrospective population-based cohort study to elucidate the occurrence of psoriasis in PCOS patients. Read More

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http://dx.doi.org/10.3390/jcm9061947DOI Listing

Tissue fat quantification by magnetic resonance imaging: proton density fat fraction in polycystic ovary syndrome.

Reprod Biomed Online 2020 May 15. Epub 2020 May 15.

Division of Endocrinology and Metabolism, Hacettepe University School of Medicine, Hacettepe Ankara 06100, Turkey; Department of Internal Medicine, Hacettepe University School of Medicine, Hacettepe Ankara 06100, Turkey. Electronic address:

Research Question: What are the potential differences between lean women with and without polycystic ovary syndrome (PCOS) in fat content in liver, vertebrae, paraspinal muscles, pancreas, subcutaneous (SCAT) and visceral adipose tissue (VAT)? Magnetic resonance imaging proton density fat fraction (PDFF) was used to establish these differences. This is a novel, non-invasive, operator-independent method with comparable diagnostic sensitivity and specificity to histologic examination for fatty liver disease, and strong correlation with muscle strength in neuromuscular studies.

Design: Twenty lean women with PCOS (mean age 23. Read More

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http://dx.doi.org/10.1016/j.rbmo.2020.04.024DOI Listing

Distinct subtypes of polycystic ovary syndrome with novel genetic associations: An unsupervised, phenotypic clustering analysis.

PLoS Med 2020 Jun 23;17(6):e1003132. Epub 2020 Jun 23.

Division of Endocrinology, Diabetes and Bone Disease, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.

Background: Polycystic ovary syndrome (PCOS) is a common, complex genetic disorder affecting up to 15% of reproductive-age women worldwide, depending on the diagnostic criteria applied. These diagnostic criteria are based on expert opinion and have been the subject of considerable controversy. The phenotypic variation observed in PCOS is suggestive of an underlying genetic heterogeneity, but a recent meta-analysis of European ancestry PCOS cases found that the genetic architecture of PCOS defined by different diagnostic criteria was generally similar, suggesting that the criteria do not identify biologically distinct disease subtypes. Read More

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http://dx.doi.org/10.1371/journal.pmed.1003132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310679PMC

Determination of the Role of Fusobacterium Nucleatum in the Pathogenesis in and Out the Mouth.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2020 Jun;41(1):87-99

"Dr. Spasovski"Skopje, R.N. Macedonia.

Introduction: One of the most important types of microorganisms in the oral cavity in both healthy and non-healthy individuals is Fusobacterium nucleatum. Although present as a normal resident in the oral cavity, this Gram-negative pathogen is dominant in periodontal disease and it is involved in many invasive infections in the population, acute and chronic inflammatory conditions, as well as many adverse events with a fatal outcome.

Aim: To determine the role of F. Read More

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http://dx.doi.org/10.2478/prilozi-2020-0026DOI Listing

Effect of Electro-acupuncture on Expression of IRS-1/PI3K/GLUT4 Pathway in Ovarian Granulosa Cells of Infertile Patients with Polycystic Ovary Syndrome-Insulin Resistance of Phlegm-Dampness Syndrome.

Chin J Integr Med 2020 Jun 22. Epub 2020 Jun 22.

Reproductive and Genetic Center of Integrated Traditional and Western Medicine, The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250011, China.

Objective: To evaluate the effect of electro-acupuncture (EA) in infertile patients with phlegm-dampness polycystic ovary syndrome-insulin resistance (PCOS-IR).

Methods: Seventy-six PCOS-IR patients who underwnet in vitro fertilization and embryo transfer (IVF-ET) were equally assigned to two groups according to a random digital table: the EA group and the control group, with 38 cases in each group. Before undergoing IVF, the two groups were treated with EA or pseudo-acupuncture, respectively, for 3 menstrual cycles. Read More

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http://dx.doi.org/10.1007/s11655-020-3219-zDOI Listing

Maternal prolactin is associated with glucose status and PCOS in pregnancy: Odense Child Cohort.

Eur J Endocrinol 2020 Jun 1. Epub 2020 Jun 1.

M Andersen, Endocrinology, Odense University Hospital, Odense, Denmark.

Objective: Low circulating prolactin is a potential marker of metabolic risk during pregnancy. We aimed to investigate associations between prolactin and glucose status in pregnant women with and without gestational diabetes mellitus (GDM) or polycystic ovary syndrome (PCOS).

Design: Prospective observational cohort study. Read More

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http://dx.doi.org/10.1530/EJE-20-0144DOI Listing

Efficacy of clomifene citrate for the treatment of patients with polycystic ovary syndrome: A protocol of systematic review.

Medicine (Baltimore) 2020 Jun;99(25):e20590

Department of Obstetrics and Gynecology, 521 Hospital of Norinco Group.

Background: This study aims to assess the efficacy and safety of clomifene citrate (CC) for the treatment of patients with polycystic ovary syndrome (PCOS).

Methods: In this study, we will comprehensively search MEDLINE, EMBASE, The Cochrane Library, Web of Science, CINAHL, ACMD, PsycINFO, and China National Knowledge Infrastructure for original articles published from their inceptions to the January 1, 2020 without language restrictions. All studies will undergo relevance and a design selecting process. Read More

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http://dx.doi.org/10.1097/MD.0000000000020590DOI Listing

Evaluation of quality of life of patients with hirsutism among Turkish women: A single-center cross-sectional study.

Authors:
Ömer Kutlu

J Cosmet Dermatol 2020 Jun 21. Epub 2020 Jun 21.

Uşak University, School of Medicine, Department of Dermatology and Venereology, Uşak, Turkey.

Background: Patients with hirsutism have an increased number of diseases such as depression, anxiety, and social isolation with decreased quality of life.

Aims: We aimed to investigate changes in the quality of life of patients with hirsutism among Turkish women.

Methods: A total of 57 patients diagnosed with hirsutism were included in this study. Read More

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http://dx.doi.org/10.1111/jocd.13563DOI Listing

New insights into anti-Müllerian hormone role in the hypothalamic-pituitary-gonadal axis and neuroendocrine development.

Cell Mol Life Sci 2020 Jun 20. Epub 2020 Jun 20.

Univ. Lille, Inserm, CHU Lille, U1172-LilNCog-Lille Neuroscience and Cognition, 59000, Lille, France.

Research into the physiological actions of anti-Müllerian hormone (AMH) has rapidly expanded from its classical role in male sexual differentiation to the regulation of ovarian function, routine clinical use in reproductive health and potential use as a biomarker in the diagnosis of polycystic ovary syndrome (PCOS). During the past 10 years, the notion that AMH could act exclusively at gonadal levels has undergone another paradigm shift as several exciting studies reported unforeseen AMH actions throughout the Hypothalamic-Pituitary-Gonadal (HPG) axis. In this review, we will focus on these findings reporting novel AMH actions across the HPG axis and we will discuss their potential impact and significance to better understand human reproductive disorders characterized by either developmental alterations of neuroendocrine circuits regulating fertility and/or alterations of their function in adult life. Read More

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http://dx.doi.org/10.1007/s00018-020-03576-xDOI Listing

Reproductive hormone metabolism in women with infertility due to polycystic ovary syndrome depending on the constitutional body types.

Pol Merkur Lekarski 2020 Jun;48(285):152

I. Horbachevsky Ternopil National Medical University, Ukraine: Department of Obstetrics and Gynaecology No.1.

Overweight or obesity is diagnosed in approximately 60-80% of polycystic ovary syndrome (PCOS) patients. Since obesity exacerbates the hormonal and clinical features of PCOS, and women suffering from PCOS have a high risk of obesity, we suggest that hormonal imbalance resulting in certain body features can be linked to the pathogenesis of PCOS.

Aim: The aim of the study was to define the features of the reproductive hormone metabolism in women with infertility due to PCOS depending on the constitutional body types. Read More

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Acne in pregnancy: A prospective multicenter, cross-sectional study of 295 patients in Turkey.

Int J Dermatol 2020 Jun 20. Epub 2020 Jun 20.

Department of Dermatology and Allergy, Technische Universität München, Munich, Germany.

Background: There are only a few studies on acne in pregnancy. This study was aimed to investigate the demographic, clinical, and familial characteristics of acne in pregnancy, triggering factors including endocrine diseases, and association of these findings with acne in different trimesters of pregnancy.

Methods: Pregnant women aged 18 years and older with acne at any stage of pregnancy were consecutively interviewed at the participating centers during the study period from 2016 to 2019. Read More

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http://dx.doi.org/10.1111/ijd.14999DOI Listing

Efficacy of sex hormone-binding globulin on predicting metabolic syndrome in newly diagnosed and untreated patients with polycystic ovary syndrome.

Hormones (Athens) 2020 Jun 20. Epub 2020 Jun 20.

Department of Endocrinology, The 1st Affiliated Hospital of Shantou University Medical College, 57 Changping Road, Shantou, 515041, Guangdong Province, China.

Purpose: The aims of this study were to investigate the correlation of sex hormone-binding globulin (SHBG) and the components of metabolic syndrome (MetS) and explore the ability of SHBG to predict MetS in newly diagnosed and untreated patients with polycystic ovary syndrome (PCOS).

Methods: Ninety-eight newly diagnosed and untreated patients with PCOS and 37 healthy volunteers were recruited. A receiver operating characteristic (ROC) curve was used to explore the best cutoff values of SHBG for predicting that the patients with PCOS would fulfill at least one abnormal index of MetS components, at least two abnormal indexes of MetS components, or MetS. Read More

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http://dx.doi.org/10.1007/s42000-020-00219-5DOI Listing

Women with polycystic ovary syndrome associated with increased anxiety risk: A population-based cohort study in Taiwan.

J Affect Disord 2020 Aug 12;273:532-537. Epub 2020 May 12.

Department of Obstetrics and Gynecology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, and Tzu Chi University, Hualien, Taiwan; Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan. Electronic address:

Background: Polycystic ovary syndrome (PCOS) has been associated with developing mental disorders in Western populations, but this association is poorly studied in Asians. Hence, using insurance claims data, this study evaluated the anxiety risk in women with PCOS.

Methods: Using Taiwan's National Health Insurance Research Database, we identified 7026 women aged 15-49 years with newly diagnosed PCOS without anxiety in 1998-2013 as the PCOS cohort. Read More

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http://dx.doi.org/10.1016/j.jad.2020.04.032DOI Listing

miR-130b regulates gap junctional intercellular communication through connexin 43 in granulosa cells from patients with polycystic ovary syndrome.

Mol Hum Reprod 2020 Jun 19. Epub 2020 Jun 19.

Department of Obstetrics and Gynecology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.

MicroRNAs (miRNAs) are small, noncoding RNAs that negatively regulate gene expression post-transcriptionally. We explored whether connexin 43 (Cx43) was differently expressed in luteinized granulosa cells from women with polycystic ovary syndrome (PCOS) compared with luteinized granulosa cells from women with a normal menstrual cycle, and whether certain miRNAs regulate the Cx43 level and gap junctional intercellular communication. The miRNA profile was investigated in ovarian cortex tissues from five women with PCOS and five women without PCOS using a miRNA microarray. Read More

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http://dx.doi.org/10.1093/molehr/gaaa044DOI Listing

Long non-coding RNA and its molecular mechanisms in polycystic ovary syndrome.

RNA Biol 2020 Jul 2:1-13. Epub 2020 Jul 2.

Center for Reproductive Medicine, Department of Gynecology and Obstetrics, Nanfang Hospital, Southern Medical University , Guangzhou, People's Republic of China.

Polycystic ovary syndrome (PCOS) causes anovulatory infertility in women of reproductive age, but etiopathogenesis of PCOS remains undetermined. Taurine up-regulated 1 (), an evolutionarily conserved long non-coding RNA, performs various biological functions; however, the role of in PCOS remains unclear. Herein, expression was assayed in granulosa cells (GCs) of 100 patients with PCOS and 100 control participants. Read More

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http://dx.doi.org/10.1080/15476286.2020.1783850DOI Listing

Significance of pro-angiogenic estrogen metabolites in normal follicular development and follicular growth arrest in polycystic ovary syndrome.

Hum Reprod 2020 Jun 19. Epub 2020 Jun 19.

Institute for Maternal and Child Research (IDIMI), Faculty of Medicine, University of Chile, Santiago, Chile.

Study Question: Do alterations in pro- and anti-angiogenic estrogen metabolites in follicular fluid (FF) contribute to the follicular growth arrest and anovulation associated with polycystic ovary syndrome (PCOS)?

Summary Answer: FF of PCOS women with anovulation have reduced levels of pro-angiogenic estrogen metabolites (EMs) and vascular endothelial growth factor (VEGF) compared to that of fertile women with regular menstrual cycles, but exogenous gonadotropins increase the pro-angiogenic EMs and VEGF levels in PCOS women.

What Is Known Already: PCOS is characterized by the arrest of follicular development that leads to chronic anovulation. Follicular arrest is generally associated with elevated plasma levels of luteinizing hormone (LH), androgens and anti-Mullerian hormone (AMH). Read More

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http://dx.doi.org/10.1093/humrep/deaa098DOI Listing

Overview of biological effects of Quercetin on ovary.

Phytother Res 2020 Jun 17. Epub 2020 Jun 17.

Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Over the last few decades, using natural products has been increased to treat different diseases. Today, great attention has been pointed toward the usage of natural products such as flavonoids, especially Quercetin (QUR), in the treatment of diseases. QUR as a natural antioxidant has been traditionally used to prevent or treat a variety of diseases such as cancer, cardiovascular disease, polycystic ovary syndrome (PCOS), obesity, chronic inflammation, and reproductive system dysfunction. Read More

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http://dx.doi.org/10.1002/ptr.6750DOI Listing

Sexual function in women with androgen excess disorders: classic forms of congenital adrenal hyperplasia and polycystic ovary syndrome.

J Endocrinol Invest 2020 Jun 15. Epub 2020 Jun 15.

Department of Internal Medicine and Endocrinology, Warsaw Medical University, 1a Banacha street, 02-097, Warsaw, Poland.

Purpose: We compared the sexual function in women with classic forms of congenital adrenal hyperplasia (CAH) and polycystic ovary syndrome (PCOS) to find if the cause of androgen excess determines sexual functioning.

Methods: Hundred and four women (21 with CAH, 63 with PCOS and 20 healthy controls) aged 18-40 years were included into the study. All participants completed a questionnaire regarding their sociodemographic background and underwent anthropometric and basic biochemical measurements. Read More

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http://dx.doi.org/10.1007/s40618-020-01332-3DOI Listing

Nonalcoholic fatty liver disease in women with polycystic ovary syndrome: associated factors and noninvasive fibrosis staging in a single Brazilian center.

Arch Endocrinol Metab 2020 May-Jun;64(3):235-242

Pós-Graduação em Ciências Aplicadas à Saúde do Adulto, Universidade Federal de Minas Gerais , Belo Horizonte , MG , Brasil.

Objective: Polycystic ovary syndrome (PCOS) is a recognized risk factor for nonalcoholic fatty liver disease (NAFLD). The aims of this study were to investigate the prevalence and factors associated with NAFLD in women with PCOS and evaluate noninvasive indices of hepatic fibrosis in patients with PCOS and NAFLD.

Subjects And Methods: Patients with PCOS (n = 87) and women without PCOS (n = 40; controls) were included. Read More

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http://dx.doi.org/10.20945/2359-3997000000242DOI Listing

Liraglutide administration improves hormonal/metabolic profile and reproductive features in women with HAIR-AN syndrome.

Endocrinol Diabetes Metab Case Rep 2020 Jun 4;2020. Epub 2020 Jun 4.

Endocrine Unit, Alexandra Hospital, Athens, Greece.

Summary: HAIR-AN syndrome, the coexistence of Hirsutism, Insulin Resistance (IR) and Acanthosis Nigricans, constitutes a rare nosologic entity. It is characterized from clinical and biochemical hyperandrogenism accompanied with severe insulin resistance, chronic anovulation and metabolic abnormalities. Literally, HAIR-AN represents an extreme case of polycystic ovary syndrome (PCOS). Read More

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http://dx.doi.org/10.1530/EDM-19-0150DOI Listing