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Horm Mol Biol Clin Investig 2021 Jun 14. Epub 2021 Jun 14.

First Department of Internal Medicine, Medical Faculty, P.J. Šafárik University, Košice, Slovakia.

Objectives: There is a growing evidence indicating an impact of endocrine distrupting chemicals such as bisphenol A (BPA) on human reproduction. Its higher levels in serum or urine have been documented in women with polycystic ovary syndrome (PCOS), however the relationship to ovarian steroidogenesis remains unclear. of the study was to compare urinary BPA (U-BPA) concentrations among PCOS women and control group. Read More

J Pediatr Adolesc Gynecol 2021 Jun 9. Epub 2021 Jun 9.

Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas; Texas Children's Hospital, Houston, Texas.

Study Objective: To identify PCOS in a population of female patients with MAS by retrospective chart review DESIGN: : Retrospective study SETTING: : Academic setting PARTICIPANTS: : All females with a prior diagnosis of MAS who were older than 12 years of age at the time of chart review. Only complete medical records from January 2009 to January 2020 were included in the analysis.

Interventions: None MAIN OUTCOME MEASURE(S): : Diagnosis of PCOS based on the Rotterdam 2003 criteria. Read More

J Clin Endocrinol Metab 2021 Jun 12. Epub 2021 Jun 12.

Section of Endocrinology and Investigative Medicine, Imperial College London, Hammersmith Hospital, London, UK.

J Reprod Immunol 2021 Jun 5;146:103345. Epub 2021 Jun 5.

Department of Biomedical Sciences, School of Bio Sciences and Technology, Vellore Institute of Technology (VIT), Vellore, Tamil Nadu, 632014, India. Electronic address:

Polycystic Ovary Syndrome (PCOS), a major endocrine disorder, affects the reproductive function of a woman, along with an association with metabolic conditions like insulin resistance and inflammation. The inflammatory nature of PCOS is much debated over, owing to numerous cases of elevation in cytokine levels. Studies have shown the beneficiary effect of Gamma-Linolenic acid (GLA) in reducing inflammation related to many conditions such as atopic dermatitis, rheumatoid arthritis, arterial disease, obesity, and even PCOS. Read More

Curr Pharm Des 2021 Jun 10. Epub 2021 Jun 10.

University Clinic of Endocrinology, Diabetes and Metabolic Disorders, Medical Faculty, University of Skopje, Skopje, Macedonia.

Metabolic syndrome (MetS) represents a cluster of metabolic disorders that arise from insulin resistance (IR) and adipose tissue dysfunction. As a consequence, there is an increased risk for type 2 diabetes mellitus and atherosclerotic cardiovascular disease (CVD). MetS is associated with a 2-fold increase in cardiovascular outcomes. Read More

Medicine (Baltimore) 2021 Jun;100(23):e26295

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.

Background: Obesity and insulin resistance (IR) are common in polycystic ovary syndrome (PCOS), which contribute to reproductive and metabolic abnormalities. Metformin increases insulin sensitivity, but it is associated with unsatisfied benefits of weight loss. Recent studies have reported that glucagon-like peptide 1 (GLP-1) receptor agonists improve IR and reduce weight in women with PCOS. Read More

Front Cell Dev Biol 2021 25;9:664843. Epub 2021 May 25.

State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot, China.

Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine and metabolic disorder in women, which is characterized by androgen excess, ovulation dysfunction, and polycystic ovary. Although the etiology of PCOS is largely unknown, many studies suggest that aberrant DNA methylation is an important contributing factor for its pathological changes. In this study, we investigated DNA methylation characteristics and their impact on gene expression in granulosa cells obtained from PCOS patients. Read More

J Ethnopharmacol 2021 Jun 7:114318. Epub 2021 Jun 7.

Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza, Postal Code: 12211, Egypt. Electronic address:

Ethnopharmacological Relevance: Chickpea was used in both greek and indian traditional medicine for hormonal related conditions as menstrual induction, acceleration of parturation, treatment of retained placenta and stimulation of lactation. Chickpea (Cicer arietinum) sprout isoflavone isolates exhibited reasonable estrogenic activities. Isoflavones, a subtype of phytoestrogens, are plant derivatives with moderate estrogenic activity that tend to have protective effects on hormonal and metabolic abnormalities of women with polycystic ovary syndrome (PCOS). Read More

Front Cell Dev Biol 2021 24;9:669189. Epub 2021 May 24.

Center for Energy Metabolism and Reproduction, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.

Hyperandrogenism is a key pathological feature of polycystic ovarian syndrome (PCOS). Excess androgen can lead to PCOS-like cell hypertrophy in the ovaries and adipose tissue of rodents. Here, we established a dihydrotestosterone (DHT)-induced hyperandrogenic mouse model to analyze the differences in gene expression and signaling pathways of the ovaries and gonad fat pads of mice treated with or without DHT by RNA microarray analysis. Read More

Front Physiol 2021 24;12:652559. Epub 2021 May 24.

Department of Academic Diabetes, Endocrinology, and Metabolism, Hull York Medical School, University of Hull, Hull, United Kingdom.

Free androgen index (FAI) and anti-Mullerian hormone (AMH) are independently associated with polycystic ovary syndrome (PCOS). This study aimed to describe the relationship between these two markers and health-related quality of life (HR-QoL) in women with PCOS. This cross-sectional study consisted of 81 women in the Hull PCOS biobank, who fulfilled the Rotterdam consensus criteria for the diagnosis of PCOS. Read More

Ann Palliat Med 2021 May;10(5):5671-5678

Department of Gynecology, the Second Hospital of Hebei Medical University, Shijiazhuang, China.

Background: Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder with complex pathogenesis. This study aimed to analyze the expression of platelet-derived growth factor (PDGF), epidermal growth factor (EGF), and insulin-like growth factor-II (IGF-II) in patients with PCOS and its correlation with pregnancy outcomes.

Methods: A total of 104 PCOS patients admitted to the Cangzhou Central Hospital from January 2015 to February 2018 were selected as the PCOS group, and 92 healthy pregnant women who received health examinations in the hospital during the same period were selected as the control group. Read More

Pharmacol Rep 2021 Jun 9. Epub 2021 Jun 9.

Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Medyków 18, 40-752, Katowice, Poland.

Background: Early-onset androgenic alopecia is regarded as the phenotypic equivalent of polycystic ovary syndrome in men. Women with polycystic ovary syndrome are at high risk of autoimmune thyroiditis. The aim of the current study was to investigate whether early-onset androgenic alopecia determines the impact of exogenous vitamin D on thyroid autoimmunity and thyroid function in men with autoimmune thyroiditis. Read More

Codas 2021 4;33(5):e20200128. Epub 2021 Jun 4.

Department of Audiology and Speech Language Pathology, Kasturba Medical College, Mangalore (Karnataka), India; Manipal Academy of Higher Education - Manipal (Karnataka), India.

Purpose: Polycystic ovary syndrome (PCOS) is heterogenous condition with commonly associated symptoms include irregular menstrual cycle, hirsutism, baldness, adult acne, and weight gain There have been few attempts at profiling the voice characteristics of women with polycystic ovary syndrome. Videokymography enables to detect even subtle variationsin vocal fold vibrations. The aim of the present study was to study the videokymographic characteristics among women with PCOS. Read More

J Physiol Pharmacol 2021 Feb 3;72(1). Epub 2021 Jun 3.

Department of Physiology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.

The safety and effectiveness of nutricetics suggest that they may offer an alternative to pharmaceutical and surgical therapy for hormone-dependent disorders, such as polycystic ovarian syndrome (PCOS). We investigated the effects of Linum usitatissimum seed oil (LSO) on ovarian functionality, its molecular targets, and the oxidative response in hyperandrogenism-induced polycystic ovary. The composition of LSO has been analyzed using ultra-performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UPLC-ESI-MS). Read More

J Physiol Pharmacol 2021 Feb 3;72(1). Epub 2021 Jun 3.

Department of Endocrinology, Institute of Zoology and Biomedical Research, Jagiellonian University in Cracow, Cracow, Poland.

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder affecting women of reproductive age. It is characterized by hormonal, reproductive and metabolic disturbances, including hyperandrogenism, altered gonadotropin level, ovarian cysts and ovulatory dysfunction as well as insulin resistance, hyperinsulinemia and dyslipidemia. It was shown that increased insulin concentration is a plausible factor in the pathogenesis of PCOS. Read More

Patient Educ Couns 2021 May 29. Epub 2021 May 29.

School of Public Health and Primary Care, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.

Objective: To explore clinicians' and women's views and experiences with managing polycystic ovary syndrome (PCOS).

Methods: Semi-structured interviews with 36 clinicians and 26 women with PCOS. Clinicians were recruited through advertising via relevant professional organisations, snowballing and contacting clinics across Australia. Read More

J Clin Lab Anal 2021 Jun 7:e23861. Epub 2021 Jun 7.

Department of Laboratory Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.

Background: We established age-group-specific reference intervals for serum anti-Müllerian hormone (AMH) levels in a Korean population and investigated the effectiveness of AMH assay for polycystic ovary syndrome (PCOS) diagnosis.

Methods: We analyzed serum levels of AMH, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) from 1540 Korean women. Subjects were divided into three groups: healthy, benign gynecologic diseases, and PCOS. Read More

J Clin Endocrinol Metab 2021 Jun 7. Epub 2021 Jun 7.

Woman's Weight Loss and Metabolic Clinic, Woman's Hospital, Baton Rouge, LA, USA.

Context: Glucagon-like peptide-1 receptor agonists and sodium-glucose co-transporter-2 inhibitors reduce weight and improve insulin sensitivity via different mechanisms.

Objective: The efficacy of once-weekly exenatide (EQW) and dapagliflozin (DAPA) alone and co-administered (EQW/DAPA), DAPA/extended release metformin (DAPA/MET), and phentermine topiramate extended release (PHEN/TPM) on metabolic parameters, body composition, and sex hormones were examined in obese women with PCOS.

Research Design And Methods: Non-diabetic women (n=119; 18-45y) with BMI>30 <45 and PCOS (NIH criteria) were randomized in a single-blind fashion to EQW (2 mg weekly); DAPA (10 mg daily), EQW/DAPA (2 mg weekly/10 mg daily), DAPA (10 mg)/MET (2000mg XR daily) or PHEN (7. Read More

J Cosmet Laser Ther 2021 Jun 5:1-4. Epub 2021 Jun 5.

Department of Dermatology, University of Health Sciences Turkey, Ankara Diskapi Education and Research Hospital, Ankara, Turkey.

: The permanence of Alexandrite laser hair removal (LHR) has been of great interest. However, studies on long-term outcome are lacking.To evaluate the hair reduction rates (HRRs) and laser parameters of patients who no longer need epilation after LHR, and redefine permanence. Read More

Nutr Metab (Lond) 2021 Jun 6;18(1):57. Epub 2021 Jun 6.

Department of Nutrition, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders among women of reproductive age. This study was designed to investigate the effects of melatonin and/or magnesium supplementation on metabolic profile and levels of sex hormones in PCOS women.

Methods: In an 8-week randomized double-blind placebo-controlled trial, 84 subjects with PCOS aged 18-40 years were randomly assigned based on the random block procedure to take magnesium, melatonin, magnesium plus melatonin, and placebo. Read More

J Endocrinol Invest 2021 Jun 5. Epub 2021 Jun 5.

Section of Endocrinology, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Via Paradisa, 2, 56124, Pisa, Italy.

Purpose: To assess the distribution of clinical features and metabolic abnormalities of polycystic ovary syndrome (PCOS) women according to their age.

Methods: Retrospective study on 602 women (mean age 23.9 ± 6. Read More

Reprod Sci 2021 Jun 3. Epub 2021 Jun 3.

Reproductive Medical Center of the Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210011, China.

There is currently a dispute over the choice of ovulation induction treatment for infertile women with polycystic ovary syndrome (PCOS). The objective of this study is to compare the therapeutic effect of pulsed rhythmic administration protocol (PRAP) with conventional letrozole + human menopausal gonadotropin (HMG) in patients with clomiphene-resistance polycystic ovary syndrome (PCOS). A retrospective analysis of 821 intrauterine insemination (IUI) cycles between January 2015 and January 2020 was performed. Read More

Front Genet 2021 18;12:648701. Epub 2021 May 18.

Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China.

Polycystic ovary syndrome (PCOS) is the most common complex endocrine and metabolic disease in women of reproductive age. It is characterized by anovulatory infertility, hormone disorders, and polycystic ovarian morphology. Regarding the importance of granulosa cells (GCs) in the pathogenesis of PCOS, few studies have investigated the etiology at a single "omics" level, such as with an mRNA expression array or methylation profiling assay, but this can provide only limited insights into the biological mechanisms. Read More

J Hum Reprod Sci 2021 Jan-Mar;14(1):21-27. Epub 2021 Mar 30.

Department of Obstetrics and Gynaecology, ART Center, All India Institute of Medical Sciences, New Delhi, India.

Context: Tonic hypersecretion of luteinizing hormone (LH) appears to impact both fertility and pregnancy outcomes in women with polycystic ovary syndrome (PCOS).

Aim: Whether high basal day 2/3 serum LH levels and day 2/3 LH/follicle-stimulating hormone (FSH) ratio affect fertilization (IVF) cycle outcomes in PCOS patients undergoing controlled ovarian hyperstimulation using gonadotropin-releasing hormone (GnRH) antagonists.

Settings And Design: A retrospective cohort study was conducted in Assisted Reproductive Technique Center, Department of Obstetrics and Gynaecology, at a tertiary care institute, on PCOS patients undergoing IVF/intracytoplasmic sperm injection (ICSI) using GnRH antagonist protocol with human chorionic gonadotropin trigger between January 2014 to December 2019. Read More

J Hum Reprod Sci 2021 Jan-Mar;14(1):11-15. Epub 2021 Mar 30.

Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health Care Training and Research Hospital, University of Health Sciences, Ankara, Turkey.

Background: Although infertility is known as a chronic inflammatory condition, the effect of the increased inflammatory response on IUI success is not clear. Systemic inflammation can be calculated by applying various hematological markers.

Aims: We aimed to evaluate the ability of hematologic parameters of inflammation in predicting intrauterine insemination (IUI) outcome. Read More

Turk J Obstet Gynecol 2021 06;18(2):124-130

Yozgat Bozok University Faculty of Medicine, Department of Obstetrics and Gynecology, Yozgat, Turkey

Objective: Delta-like 1 (DLK1) is known to inhibit adipocyte differentiation and nesfatin-1 is a neuropeptide that plays a role in the regulation of nutrition and metabolism. We aimed to assess both the levels of DLK1 and nesfatin-1 in polycystic ovary syndrome (PCOS) and determine the association of DLK1 and nesfatin-1 with metabolic parameters.

Materials And Methods: Forty-four patients with PCOS and 40 healthy women as the control group were included in this study. Read More

Eur J Endocrinol 2021 Jun 1. Epub 2021 Jun 1.

E Kajantie, Population Health Unit, Finnish Institute for Health and Welfare, Oulu and Helsinki, Finland.

Objective: It has been suggested that adverse early life exposures increase the risk of developing polycystic ovary syndrome (PCOS) in later life. We hypothesized that women born preterm would have more biochemical and clinical signs of PCOS than women born at term.

Design: The ESTER Preterm Birth Study participants were born in Northern Finland, and identified from the Northern Finland Birth Cohort and the Finnish Medical Birth Register. Read More

Comb Chem High Throughput Screen 2021 Jun 2. Epub 2021 Jun 2.

Guangzhou University of Chinese Medicine, Guangzhou 515000, China.

Background: Polycystic ovary syndrome (PCOS) is a common endocrine disease in women that seriously interferes with the patient's metabolic and reproductive functions. The current diagnostic criteria for PCOS are expert-based and still disputed. Previous studies have identified changes in DNA methylation in peripheral blood of women with PCOS, but their diagnostic potential for PCOS remains to be studied. Read More

Cureus 2021 Apr 28;13(4):e14735. Epub 2021 Apr 28.

Adult Endocrinology, Faiha Specialized Diabetes, Endocrine and Metabolism Center (FDEMC) College of Medicine, University of Basrah, Basrah, IRQ.

Background and objective We lack a reliable and validated health-related quality of life (HRQoL) questionnaire to measure the negative impact of polycystic ovary syndrome (PCOS) on the various aspects of the lives of Arabic women, which addresses sexuality in married women only. Hence, we aimed to develop two separate, simple, reliable, validated, and easily interpretable HRQoL questionnaires in Arabic for married and unmarried women with PCOS for effective QoL evaluation. Materials and methods The development and reliability analysis of the Polycystic Ovary Syndrome Quality of Life (PCOSQoL)-47 and PCOSQoL-42 involved two quantitative and qualitative phases. Read More

Front Immunol 2021 17;12:685724. Epub 2021 May 17.

Guangdong Women and Children Hospital, Guangzhou Medical University, Guangzhou, China.

Background: Hormones and immune imbalance are critical factors in polycystic ovary syndrome (PCOS). The alternation of immune microenvironment of oocytes may play a significant role in infertility of PCOS patients.

Objective: This study explores the role of follicular fluid microenvironment change in inflammatory pathways activation of granulosa cells (GCs) in PCOS women infertility. Read More