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Rev Assoc Med Bras (1992) 2019 Mar 11;65(3):375-383. Epub 2019 Apr 11.

Department of Psychobiology, Federal University of Sao Paulo, Sao Paulo, SP, Brasil.

Objective: This study aims to evaluate the sleep of subjects with polycystic ovary syndrome (PCOS), with and without hyperandrogenism, in comparison with a healthy control group and examine the effects of hyperandrogenism and obesity on sleep parameters.

Methods: A total of 44 volunteers were recruited to participate in the study. Clinical, biochemical and polysomnographic parameters were used to diagnose PCOS and hyperandrogenism. Read More

Arq Bras Cardiol 2019 Apr;112(4):430-431

Faculdade de Ciencias Medicas de Minas Gerais, Belo Horizonte, MG - Brazil.

Acta Obstet Gynecol Scand 2019 Apr 16. Epub 2019 Apr 16.

Women's Health and Perinatology Research Group, Department of Clinical Medicine, UiT-The Arctic University of Norway, Tromsø, Norway.

Introductio: High levels of anti-Mullerian hormone and a high antral follicle count in women with polycystic ovary syndrome, reflecting increased ovarian antral follicles, predisposes them to have a high number of retrieved oocytes at in-vitro fertilisation (IVF)/ intra-cytoplasmic sperm injection (ICSI) and an increased risk of ovarian hyperstimulation syndrome. Inositols, which act as insulin sensitizers have the potential to alter folliculogenesis and the functional ovarian reserve with subsequent benefits to reproductive outcomes following IVF/ICSI treatment. Published literature is however unable to provide definitive evidence of its efficacy. Read More

Endocrine 2019 Apr 16. Epub 2019 Apr 16.

Department of Medicine, University of Padova, Padova, Italy.

Purpose: Hormonal status and menopause affect human macrophage function and cardiometabolic risk. In polycystic ovary syndrome (PCOS) patients the cardiometabolic risk increases through mechanisms that are largely unknown. We tested the hypotheses that macrophage activation is influenced by menstrual cycle and that ovarian dysfunction in PCOS patients is associated with altered macrophage inflammatory responses and cholesterol efflux capacity of serum HDL. Read More

Hum Cell 2019 Apr 16. Epub 2019 Apr 16.

Department of Gynaecology and Obstetrics, Beijing United Family Hospital, Beijing, 100016, China.

Obese women with polycystic ovary syndrome (PCOS) often suffer from ovulation failure, which may be driven by granulosa cells (GCs) injury caused by increased levels of circulating oxidized low-density lipoprotein (ox-LDL) and luteinizing hormone (LH). PGC-1α may play an important role in this pathophysiological processes. However, the effect and the potential mechanism of PGC-1α on GCs injury evoked by obese PCOS is fully unclear. Read More

Biomed Res Int 2019 12;2019:6235680. Epub 2019 Mar 12.

Department of Obstetrics and Gynecology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.

Polycystic ovary syndrome (PCOS) is the commonest endocrine disorder affecting women of reproductive age. Its aetiology, though yet unclear, is presumed to have an oligogenic basis interacting with environmental factors. Kisspeptins are peptide products of Kiss1 gene that control the hypothalamic pituitary (HPG) axis by acting via G protein-coupled receptor known as GPR54. Read More

Trials 2019 Apr 16;20(1):221. Epub 2019 Apr 16.

Institute for Health and Sport, Victoria University, PO Box 14428, Melbourne, Victoria, 8001, Australia.

Background: Polycystic ovary syndrome (PCOS) is a reproductive-metabolic condition. Insulin resistance is a hallmark of PCOS and is related to increased hyperandrogenism that drives inherent metabolic, reproductive and psychological features of the syndrome. Insulin resistance in women with PCOS is managed by weight loss, lifestyle interventions (i. Read More

Endocr Connect 2019 Apr 1. Epub 2019 Apr 1.

H Dieplinger, Genetic Epidemiology, Innsbruck Medical University, Innsbruck, A-6020, Austria.

Background: Patients suffering from polycystic ovary syndrome (PCOS) are often insulin-resistant and at elevated risk for developing gestational diabetes mellitus (GDM). The aim of this study was to explore afamin, which can be determined preconceptionally to indicate patients who will subsequently develop GDM. Serum concentrations of afamin are altered in conditions of oxidative stress like insulin resistance (IR) and correlate with the gold standard of IR determination, the HOMA index. Read More

Ugeskr Laeger 2019 Apr;181(15)

Since 2004, the Rotterdam criteria have been used in the diagnosis of polycystic ovary syndrome (PCOS), requiring the presence of two of the following three criteria: oligo-/anovulation, hyperandrogenism or polycystic ovaries. Reports of high prevalences of polycystic ovaries in younger women have caused concerns about overdiagnosis. Recently, the international guideline for PCOS has recommended raising the follicle threshold for polycystic ovaries and avoiding ultrasound in adolescents. Read More

Gynecol Endocrinol 2019 Apr 16:1-6. Epub 2019 Apr 16.

a Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences , Tehran , Iran.

Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in reproductive-age women. Significant associations between PCOS and benign breast diseases (BBD) and a possibly potential association between PCOS and breast cancer have been reported. The etiology of these events of mammary glands in PCOS remains unclear. Read More

Zhongguo Zhong Yao Za Zhi 2019 Mar;44(6):1080-1086

Xiyuan Hospital,China Academy of Chinese Medicine Sciences Beijing 100091,China.

Meta-analysis of randomized controlled trials( RCTs) was conducted to clarify the effect of Bushen Huoxue herbal medicine in subfertile women with polycystic ovary syndrome. Databases including CNKI,Wan Fang,VIP,Sino Med,PubMed,EMbase,the Cochrane Library were searched until September,2018. Two reviewers independently assessed study eligibility,extracted data,and evaluated the risk of bias for included trials. Read More

J Cell Physiol 2019 Apr 15. Epub 2019 Apr 15.

Department of Obstetrics and Gynecology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

In this study, we aimed to investigate the molecular pathway(s) underlying the effect of metformin (MET) on the expression of matrix metalloproteinase (MMP)-2 and MMP-9. Real-time polymerase chain reaction, Western blot analysis, and gelatin zymography were used to assay the effects of MET on MMP and AMPK signaling pathways. In addition, HTOG cells were treated with miR-29b-3p/a scramble control, H19/a negative control, or MET/PBS to explore possible signaling pathway(s) underlying the inhibitory effect of MET on MMP-2/MMP-9. Read More

Exp Ther Med 2019 May 22;17(5):4013-4022. Epub 2019 Mar 22.

Department of Obstetrics and Gynecology, Başkent University School of Medicine, 06490 Ankara, Turkey.

The role of metformin in the management of polycystic ovary syndrome (PCOS) and PCOS-related obesity remains controversial. Recent research on the treatment of PCOS-related obesity investigated novel therapeutic agents with the potential to work synergistically with metformin. The aim of the present study was to determine the synergistic effect of a phosphodiesterase 4 inhibitor (PDE4i) and metformin on weight and hormonal changes in a rat model of PCOS. Read More

Exp Ther Med 2019 May 6;17(5):3501-3508. Epub 2019 Mar 6.

Department of Gynecology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, P.R. China.

Tanshinone IIA (TSIIA) is a major component of , a Chinese herb that exhibits a therapeutic effect on polycystic ovary syndrome (PCOS). The present study replicated PCOS via the neonatal treatment of estradiol in mice. Estrous cycles, body and ovarian weight, serum levels of testosterone and estradiol were determined. Read More

Sci Rep 2019 Apr 15;9(1):6040. Epub 2019 Apr 15.

Reproductive medical center, Guangdong Women and Children Hospital, Guangzhou Medical University, 511400, Guangzhou, China.

Immune responses play an important role in the pathogenesis of polycystic ovary syndrome (PCOS). However, the characteristics of T lymphocyte subsets in PCOS remain insufficiently understood. In this study, lymphocytes of follicular fluid (FF) were obtained from oocyte retrieval before in-vitro fertilization (IVF) in infertile women with or without PCOS. Read More

J Clin Endocrinol Metab 2019 Apr 15. Epub 2019 Apr 15.

Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, CA.

Purpose: To 1) determine whether women with polycystic ovary syndrome (PCOS) from a population-based cohort experience elevated depression symptoms, and 2) characterize the trajectory of symptoms over the lifespan.

Methods: The association between PCOS and longitudinal depression scores was investigated among 1,127 black and white women participating in Coronary Artery Risk Development in Young Adults (CARDIA) study. PCOS was ascertained at baseline (ages 20-32) by NIH criteria, incorporating androgens and symptoms of oligomenorrhea and hirsutism. Read More

Food Funct 2019 Apr 15. Epub 2019 Apr 15.

Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University (BTBU), Beijing 100048, Peoples' Republic of China. and College of Life Science, Capital Normal University, Beijing 100048, Peoples' Republic of China.

Polycystic ovary syndrome (PCOS) is a common endocrine disorder, which is characterized by hyperandrogenism. Polyunsaturated fatty acids (PUFAs) are necessary for the body's metabolism, growth and development. Despite the well-known benefits of omega-3 polyunsaturated fatty acid supplementation on the modulation of PCOS ovarian function, relatively little is known about the precise regulation mechanism. Read More

Front Endocrinol (Lausanne) 2019 29;10:200. Epub 2019 Mar 29.

Sport, Health and Exercise Science, Faculty of Health Sciences, University of Hull, Kingston upon Hull, United Kingdom.

Endothelial dysfunction is a known comorbidity in women with polycystic ovary syndrome (PCOS). The aim was to assess if supervised, moderate intensity exercise could potentially impact markers of endothelial disruption; endothelial cell derived microparticles (EMP). The current study investigated the effects of a supervised 8-week moderate intensity exercise programme on EMP in women with PCOS ( = 11) and control women free from any known disease ( = 10). Read More

Indian J Dermatol 2019 Mar-Apr;64(2):115-121

Department of Dermatology, Bankura Sammilani Medical College, Bankura, West Bengal, India.

Background: Acanthosis nigricans has been associated with conditions of insulin resistance such as obesity, polycystic ovary syndrome, and type 2 diabetes. Metformin and alpha-lipoic acid, two types of insulin-sensitizing agents, have been demonstrated to reduce insulin levels and improve insulin sensitivity. Alpha-lipoic acid is available as a fixed-dose combination with biotin, calcium pantothenate, and zinc sulfate as Canthex™. Read More

J Obstet Gynaecol 2019 Apr 15:1-6. Epub 2019 Apr 15.

b The Institute of Reproductive Medicine and Population Medical Research Centre , Seoul National University College of Medicine , Seoul , Korea.

Many studies have reported an increased arterial stiffness using pulse wave velocity (PWV) in women with polycystic ovary syndrome (PCOS). However, PWV is essentially dependent on blood pressure (BP) at the time of measurement. The cardio-ankle vascular index (CAVI) is a relatively new index for measuring arterial stiffness, and its conspicuous feature is its independency from the BP at the time of measurement. Read More

Endocr J 2019 Apr 13. Epub 2019 Apr 13.

Department of Obstetrics and Gynecology, the First Clinical Medical College of Jinan University, Guangzhou, Guangdong 510632, China.

Polycystic ovary syndrome (PCOS) represents a serious reproductive and endocrine condition and is associated with high incidence rates. H19 is a compelling long noncoding RNA (lncRNA) which carries out a range of biological functions. However, prior to this study, little was known as to whether there was an association between lncRNA H19 and PCOS. Read More

Gynecol Endocrinol 2019 Apr 15:1-4. Epub 2019 Apr 15.

a Department of Biopathology - Microbiology and Biochemistry , Aretaieion Hospital National and Kapodistrian University of Athens , Athens , Greece.

Irisin, a novel exercise-induced myokine, has been implicated in different aspects of human metabolism and could be connected to polycystic ovary syndrome (PCOS). This study aimed to investigate serum and follicular fluid (FF) irisin levels in PCOS and normal women undergoing controlled ovarian stimulation and correlate them to the lipid and lipoprotein levels as well as with other metabolic parameters. Serum and FF irisin, together with serum lipid and lipoprotein levels were assessed in 70 women with diagnosed PCOS and 70 non-PCOS controls, under in vitro fertilization (IVF) treatment. Read More

Contraception 2019 Apr 10. Epub 2019 Apr 10.

Sexual Health and Reproductive Equity Program, School of Social Welfare, University of California, Berkeley, 110 Haviland Hall MC 7400, Berkeley, CA 94720-7400, USA.

Objective: To explore perspectives on family planning among young people who perceive they are infertile or will have difficulty carrying a pregnancy to term owing to medical conditions or procedures.

Methods: This exploratory analysis examined pregnancy plans and contraceptive behavior among 12 young adults with a diagnosed medical condition or who had undergone a medical procedure associated with impaired fertility, and who had discussed fertility with a healthcare provider. We utilized data from a larger study investigating prospective pregnancy intentions and plans among 50 young (ages 18-24) women and their male partners (n=100). Read More

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

Interne Abteilung, Landeskrankenhaus Hochzirl - Natters, Hochzirl, Österreich.

Metabolic diseases dramatically affect the life of men and women from infancy up to old age in different and manifold ways and are a major challenge for the healthcare system. The treating physicians are confronted with the different needs of women and men in the clinical routine. Gender-specific differences affect screening, diagnostic and treatment strategies as well as the development of complications and mortality rates. Read More

Reprod Biomed Online 2019 Jan 18. Epub 2019 Jan 18.

First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China. Electronic address:

Research Question: What is the association between hyperhomocysteinaemia (HHCY), metabolic syndrome, and reproductive outcomes among women with polycystic ovary syndrome (PCOS).

Design: A secondary analysis of PCOSAct with 21 sites in China. A total of 1000 women with PCOS were enrolled; 936 women with baseline homocysteine (HCY) were analysed. Read More

Fertil Steril 2019 Apr 9. Epub 2019 Apr 9.

Reproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China. Electronic address:

Objective: To determine aberrant circular RNA (circRNA) expression profiles in cumulus cells from polycystic ovarian syndrome (PCOS) patients and identify their potential biological functions.

Design: Circular RNAs microarray analysis of human tissue.

Setting: University hospital. Read More

Biol Trace Elem Res 2019 Apr 11. Epub 2019 Apr 11.

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I.R., Iran.

The primary aim of our study was to determine the influence of taking chromium plus carnitine on insulin resistance, with a secondary objective of evaluating the influences on lipid profiles and weight loss in overweight subjects with polycystic ovary syndrome (PCOS). In a 12-week randomized, double-blind, placebo-controlled clinical trial, 54 overweight women were randomly assigned to receive either supplements (200 μg/day chromium picolinate plus 1000 mg/day carnitine) or placebo (27/each group). Chromium and carnitine co-supplementation decreased weight (- 3. Read More

Clin Nutr 2019 Apr 1. Epub 2019 Apr 1.

Diabetes, Obesity and Human Reproduction Research Group, Department of Endocrinology & Nutrition, Hospital Universitario Ramón y Cajal, Universidad de Alcalá & Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, Spain. Electronic address:

Background & Aims: Most evidence linking the polycystic ovary syndrome (PCOS) with chronic low-grade inflammation has been obtained in the fasting state. We have studied the postprandial inflammatory response to oral glucose, lipid and protein challenges and the possible influences of obesity, sex and PCOS on these responses.

Methods: On alternate days, we submitted 17 women with PCOS (9 non-obese, 8 obese), 17 control women (9 non-obese, 8 obese) and 19 control men (10 non-obese, 9 obese) to isocaloric (300 Kcal) oral macronutrient loads. Read More

Clin Epigenetics 2019 Apr 11;11(1):61. Epub 2019 Apr 11.

Department of Molecular Endocrinology, ICMR-National Institute for Research in Reproductive Health, J.M. Street, Parel, Mumbai, Maharashtra, 400012, India.

Background: Women with polycystic ovary syndrome (PCOS) manifest a host of ovarian defects like impaired folliculogenesis, anovulation, and poor oocyte quality, which grossly affect their reproductive health. Addressing the putative epigenetic anomalies that tightly regulate these events is of foremost importance in this disorder. We therefore aimed to carry out DNA methylome profiling of cumulus granulosa cells and assess the methylation and transcript expression profiles of a few differentially methylated genes contributing to ovarian defects in PCOS. Read More

Chin Med J (Engl) 2019 Apr 3. Epub 2019 Apr 3.

Reproductive Center, Department of Gynecology and Obstetrics, Sun Yat-sen University, Guangzhou, Guangdong 510120, China.

Background: There is no absolute consensus for the best time for triggering. The aim of this study was to investigate the effect of different proportion of dominant follicles (PDF) on the human chorionic gonadotropin (HCG) day for the clinical outcomes in patients with polycystic ovary syndrome (PCOS) of different ovarian stimulation protocols.

Methods: A total of 371 cycles of the gonadotropin-releasing hormone (GnRH) agonist long protocol and 347 cycles of GnRH antagonist protocol from January, 2014 to December, 2016 were included in this retrospective study. Read More

Angiology 2019 Apr 10:3319719840091. Epub 2019 Apr 10.

1 First Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of childbearing age. The criteria required for the diagnosis identify various phenotypes, with different reproductive, metabolic, and cardiovascular (CV) risk characteristics. Emerging evidence links adipocyte-secreted hormones as candidates in the pathogenesis of endothelial dysfunction in PCOS, independently of additional risk factors. Read More

Clin Lab 2019 Apr;65(4)

Background: Kruppel-like factor 7 (KLF7) is associated with type 2 diabetes and obesity; however, at present the KLF7 level in polycystic ovary syndrome (PCOS) remains unreported.

Methods: In this study, serum KLF7, glucose, insulin, C-reactive protein (CRP), follicle-stimulating hormone (FSH), luteinizing hormone (LH), and total testosterone concentrations were measured in 65 women with PCOS and 61 healthy controls.

Results: Body mass index (BMI) in PCOS and the control group were all < 25 kg/m2. Read More

Proteomics Clin Appl 2019 Apr 9:e1800184. Epub 2019 Apr 9.

Institute for Life Sciences, University of Southampton, Southampton, UK.

Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder associated with insulin resistance, even in the absence of overweight/obesity. The aim of the present study was to examine the global serum proteomic profile of adolescent, normal-weight females with PCOS in order to gain novel insight in the association of this endocrine disorder with insulin physiology but also identify novel circulating markers that can guide intervention protocols.

Methods: Non-depleted serum from normal-weight (BMI: 18-23 kg/m ), adolescent females (13 to 21 years old) with PCOS (n = 20) was compared to BMI- and age-matched healthy controls (n = 20) using our three-dimensional quantitative proteomics methodology. Read More

Indian J Med Res 2018 Dec;148(Supplement):S151-S155

Department of Clinical Biochemistry/Biochemistry, University of Kashmir, Srinagar, India.

Background & Objectives: Polycystic ovary syndrome (PCOS) is an endocrinopathy warranting lifelong individualized management by lifestyle and pharmacological agents mainly oral contraceptive pills (OCPs). This study was aimed to report the impact of six-month OCP use on plasminogen activator inhibitor-1 (PAI-1) and factor VIII (FVIII) in women with PCOS.

Methods: PCOS women diagnosed on the basis of Rotterdam 2003 criteria, either treated with OCPs (ethinyl estradiol-0. Read More

Dermatol Ther 2019 Apr 8:e12898. Epub 2019 Apr 8.

Department of Dermatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.

Pemphigoid gestationis (PG) is a rare, autoimmune, subepidermal bullous dermatosis associated with pregnancy. It's mainly caused by autoantibodies against hemidesmosomal proteins - bullous pemphigoid 180, and usually presents in the second or third trimester of pregnancy sometimes exacerbates spontaneously after delivery. Here we reported a case of PG with polycystic ovary syndrome. Read More

Biol Trace Elem Res 2019 Apr 8. Epub 2019 Apr 8.

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, IR, Iran.

This study was performed to determine the effects of selenium supplementation on clinical symptoms and gene expression related to inflammatory markers in infertile women with polycystic ovary syndrome (PCOS) who were candidate for in vitro fertilization (IVF). Thirty-six women candidate for IVF were recruited in this randomized double-blinded, placebo-controlled trial. They (n = 18/group) were randomly assigned into intervention groups to take either 200 μg/day of selenium or placebo for 8 weeks. Read More

Int J Vitam Nutr Res 2019 Apr 8:1-7. Epub 2019 Apr 8.

4 Department of Biostatistics and Epidemiology, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Polycystic ovary syndrome is one of the most important factors in female infertility. Oxidative stress is likely to contribute to increased insulin and androgen production in the ovaries, as well as probably impairing follicle production.

Aims: This study aims to determine the complementary effects of omega-3 and vitamin E supplements on certain oxidative stress indices in obese and overweight women with polycystic ovary syndrome. Read More

Int J Mol Sci 2019 Apr 7;20(7). Epub 2019 Apr 7.

Department of Obstetrics and Gynecology, College of Medicine and Hospital, National Cheng Kung University, Tainan 704, Taiwan.

Insulin-sensitizer treatment with metformin is widely used in polycystic ovary syndrome (PCOS). However, the treatment effectiveness shows individual differences in PCOS patients. Organic cation transporter (OCT) 1 and 2 have been reported to mediate metformin transport in the liver and kidney, respectively. Read More

Reproduction 2019 Apr 1. Epub 2019 Apr 1.

M Cerbón, Faculty of Chemistry, National autonomous University of Mexico, D.F., Mexico.

Polycystic ovary syndrome (PCOS) is the leading endocrine and metabolic disorder in premenopausal women characterized by hyperandrogenism and abnormal development of ovarian follicles. To date, the PCOS etiology remains unclear and has been related to insulin resistance, obesity, type 2 diabetes mellitus, cardiovascular disease, and infertility, among other morbidities. Substantial evidence illustrates the impact of genetic, intrauterine, and environmental factors on the PCOS etiology. Read More

Syst Biol Reprod Med 2019 Apr 8:1-9. Epub 2019 Apr 8.

a Centre for Medical Biotechnology , Maharshi Dayanand University , Rohtak , India.

Altered folliculogenesis and reproductive anomalies in polycystic ovary syndrome (PCOS) suggest that variations of genes involved in folliculogenesis might influence etiopathogenesis of this syndrome. The objective of this study was to assess the association of LHβ (rs1056917) and lutropin receptor (LHR) (rs61996318) polymorphism with polycystic ovarian syndrome and to interrelate the levels of luteinizing hormone (LH) with severity of clinical manifestations of PCOS. Three hundred women of reproductive age were enrolled in this retrospective case-control study. Read More

Gynecol Endocrinol 2019 Apr 7:1-4. Epub 2019 Apr 7.

a Departments of Obstetrics and Gynecology , General Hospital, Tianjin Medical University , Tianjin , China.

Kisspeptin has been shown to participate in the regulation of pituitary hormone secretion and energy metabolism. In PCOS patients, there are disorders in pituitary hormone secretion and energy metabolism. The aim of this study was to investigate the serum kisspeptin and its relationship with abnormal metabolism in PCOS. Read More

J Health Psychol 2019 Apr 8:1359105319840696. Epub 2019 Apr 8.

University of Windsor, Canada.

Polycystic ovary syndrome is the most common endocrine disorder among women aged from 18 to 40 years. Its debilitating menstrual/obesity-related symptoms challenge conceptions of femininity. To date, age-related differences in women's body esteem and physicians' symptom management recommendations have not been investigated. Read More

Cureus 2019 Jan 25;11(1):e3956. Epub 2019 Jan 25.

Dermatology, San Diego Family Dermatology, San Diego, USA.

Polycystic ovarian syndrome is an endocrine disorder diagnosed commonly in young women. Various cutaneous manifestations can include acanthosis nigricans, acne, hirsutism, and alopecia. Confluent and reticulated papillomatosis is a rare skin condition that may be associated with polycystic ovarian syndrome. Read More

Reprod Biol Endocrinol 2019 Apr 5;17(1):34. Epub 2019 Apr 5.

Department of Natural Science and Environment, Universitetsvej 1, 4000, Roskilde, Denmark.

Background: Women with Polycystic Ovary Syndrome (PCOS) present a heterogeneous reproductive and metabolic profile with an increased lifetime risk of Type 2 Diabetes (T2D). Early biomarkers of these metabolic disturbances in PCOS women have not been identified. The abundance of circulating insulin gene promotor cell-free DNA (INS cfDNA) was shown to be valuable as a predictive biomarker of β-cell death in individuals with Type 1 diabetes (T1D) as well as with gestational diabetes. Read More

Obes Surg 2019 Apr 5. Epub 2019 Apr 5.

Department of Surgery, Federal University of Pernambuco, Recife, PE, Brazil.

Purpose: To prospectively evaluate the hormonal profile and weight loss of women with obesity and PCOS submitted to sleeve gastrectomy (SG).

Methods: A Prospective study carried out at the Hospital das Clínicas, Federal University of Pernambuco, Recife, Brazil, in 2018, where 18 patients with PCOS, whose age varied from 18 to 40 years, with an indication for bariatric surgery were evaluated. Plasma estradiol (E2), fasting insulin, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) were measured prior to bariatric surgery and 3 months after surgery. Read More

Arch Gynecol Obstet 2019 Apr 5. Epub 2019 Apr 5.

Health Evaluation Center, Affiliated Hospital of Putian College, Putian City, 351100, Fujian, China.

Purpose: Oral antidiabetic medication of metformin is increasingly used in pregnant women with gestational diabetes mellitus (GDM), polycystic ovary syndrome (PCOS) and obesity. The drug passes through the placenta and can potentially influence the fetus. The aim of the study is to investigate the possible long-term effects of prenatal exposure to metformin on growth and development of the offspring. Read More

Endocrinology 2019 Apr 5. Epub 2019 Apr 5.

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX.

Ovarian theca androgen production is regulated by the pituitary luteinizing hormone (LH) and intra-follicular factors. Enhanced androgen biosynthesis by theca cells contributes to polycystic ovary syndrome (PCOS) in women, but the ovarian consequences of elevated androgens are not completely understood. Our study documents the molecular events that are altered in the theca and stromal cells of mice exposed to high androgen levels, using the non-aromatizable androgen DHT. Read More

Ginekol Pol 2019 ;90(3):115-121

Pomeranian Medical University in Szczecin, Poland.

O: BJECTIVES: Copeptin has been reported to play an important role in metabolic response in women with PCOS. However, the optimal cut-off value for detecting subjects with insulin resistance (IR) remains undetermined. We investigated whether copeptin can serve as an indicator of IR and tried to determine the optimal cut-off value of plasma copeptin concentration in detecting subjects with PCOS and IR. Read More

Front Endocrinol (Lausanne) 2019 21;10:174. Epub 2019 Mar 21.

CUHK-SDU Joint Laboratory on Reproductive Genetics, School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong.

The granulosa cell (GC) is a critical somatic component of the ovary. It is essential for follicle development by supporting the developing oocyte, proliferating and producing sex steroids and disparate growth factors. Knowledge of the GC's function in normal ovarian development and function, and reproductive disorders, such as polycystic ovary syndrome (PCOS) and premature ovarian failure (POF), is largely acquired through clinical studies and preclinical animal models. Read More

Am Surg 2019 Mar;85(3):252-255

Polycystic ovary syndrome (PCOS) is a common disease among the bariatric population. However, there are limited data regarding the impact of laparoscopic sleeve gastrectomy (SG) on these patients. The study was conducted at University Hospital, United States. Read More