30,780 results match your criteria Polycystic Kidney Disease


Activation of TGF-β1/Smad3 signaling pathway inhibits the development of ovarian follicle in polycystic ovary syndrome by promoting apoptosis of granulosa cells.

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

Department of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P.R. China.

Objective: To investigate the role of the transforming growth factor-β1 (TGF-β1)/Smad3 signaling pathway in development of ovarian follicle by promoting apoptosis of granulosa cells in polycystic ovary syndrome (PCOS).

Methods: A total of 54 female rats were obtained and randomly assigned into the PCOS (n = 27) and control groups ( n = 27). PCOS rat models were constructed using the dehydroepi-androsterone method to observe ovarian morphology and ultrastructure. Read More

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December 2018

Risk of cancer after assisted reproduction: a review of the available evidences and guidance to fertility counselors.

Eur Rev Med Pharmacol Sci 2018 Nov;22(22):8042-8059

Gynecological Oncology, National Cancer Institute, Aviano, Italy.

Objective: Infertile women requiring ovarian stimulation and assisted reproduction techniques (ART) are faced with difficult issues. The fear that using hormones could increase their risk of cancer is the most significant. One of the main challenges for assessing cancer risk after ART is the difficulty to separate it from the underlying condition of infertility per se. Read More

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November 2018

Effect of anti-mullerian hormone on stem cell factor in serum, follicular fluid and ovarian granular cells of polycystic ovarian syndrome patients.

Eur Rev Med Pharmacol Sci 2018 Nov;22(22):7877-7882

Jinan Maternity and Child Health Care Hospital, Jinan, Shandong, China.

Objective: Polycystic ovarian syndrome (PCOS) is a common disorder in gynecological practice. Anti-mullerian hormone (AMH) and ovarian granular stem cell factor (SCF) participate in the occurrence and progression of PCOS. This study aimed to investigate the expression of AMH and SCF in PCOS patients and attempt to analyze the effect of AMH on SCF. Read More

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November 2018

Neuroendocrine characteristics of induced pluripotent stem cells from polycystic ovary syndrome women.

Protein Cell 2018 Dec 10. Epub 2018 Dec 10.

Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology and Key Laboratory of Assisted Reproduction, Ministry of Education, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, 100191, China.

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December 2018

Advantages of Serum Anti-Müllerian Hormone as a Marker for Polycystic Ovarian Syndrome.

Lab Med 2018 Dec 10. Epub 2018 Dec 10.

Clinical Laboratory, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

Objective: To evaluate the advantages of using anti-Müllerian hormone (AMH) in the diagnosis of polycystic ovary syndrome (PCOS).

Methods: We compared data from 56 Han Chinese patients with PCOS and 52 female control Han Chinese individuals in terms of biochemical markers and the antral follicle count (AFC). Then, the correlation between serum AMH levels and various endocrine and metabolic factors was analyzed. Read More

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December 2018

Reproductive and Behavior Dysfunction Induced by Maternal Androgen Exposure and Obesity Is Likely Not Gut Microbiome-Mediated.

J Endocr Soc 2018 Dec 15;2(12):1363-1380. Epub 2018 Oct 15.

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder of unclear etiology in women and is characterized by androgen excess, insulin resistance, and mood disorders. The gut microbiome is known to influence conditions closely related with PCOS, and several recent studies have observed changes in the stool microbiome of women with PCOS. The mechanism by which the gut microbiome interacts with PCOS is still unknown. Read More

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December 2018

Data on the assessment of LV mechanics by speckle tracking echocardiography in ADPKD patients.

Data Brief 2018 Dec 14;21:2075-2081. Epub 2018 Nov 14.

IRCCS - Istituto di Ricerche Farmacologiche "Mario Negri", Clinical Research Centre for Rare Diseases "Aldo e Cele Daccò", Bergamo, Italy.

In this article, we report anthropometric, clinical and laboratory data from Autosomal Dominant Polycystic Kidney Disease (ADPKD) patients with mild to moderate renal dysfunction and normal LV ejection fraction and from age- and sex-matched healthy controls and renal controls. Factors influencing LV untwisting rate in the group of ADPKD patients are also reported. For further interpretation and discussion please refer to the research article "Left ventricular dysfunction in ADPKD and effects of Octreotide-LAR: a cross-sectional and longitudinal sub study of the ALADIN trial" (Spinelli et al. Read More

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December 2018

Effectiveness and safety of in vitro maturation of oocytes versus in vitro fertilisation in women with high antral follicle count: study protocol for a randomised controlled trial.

BMJ Open 2018 Dec 9;8(12):e023413. Epub 2018 Dec 9.

Department of Obstetrics and Gynaecology, School of Medicine, Monash University, Melbourne, Victoria, Australia.

Introduction: In vitro maturation (IVM) is a potential alternative to conventional in vitro fertilisation (IVF) to avoid ovarian hyperstimulation syndrome (OHSS). This is particularly relevant in women with a high antral follicle count (AFC) and/or polycystic ovary syndrome (PCOS), who are at increased risk for OHSS. However, no randomised controlled trials of IVM versus IVF in women with high AFC have reported both pregnancy and OHSS rates. Read More

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December 2018

Anti-Müllerian Hormone in Girls with Premature Adrenarche: The Impact of Polycystic Ovary Syndrome History in their Mothers.

J Pediatr 2018 Oct 24. Epub 2018 Oct 24.

Division of Endocrinology Department of Pediatrics, Medical School, University of Patras, Patra, Greece. Electronic address:

Objectives: To assess whether the serum levels of anti-Müllerian hormone (AMH) are increased in girls with premature adrenarche because they are at a higher risk of developing polycystic ovary syndrome (PCOS) later in life.

Study Design: We measured serum levels of AMH, dehydroepiandrosterone sulfate (DHEAS), testosterone, sex hormone binding globulin, androstenedione, and 17-hyroxyprogesterone in 89 girls with premature adrenarche aged 6.98 ± 1. Read More

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October 2018

Higher luteinizing hormone levels associated with antimüllerian hormone in postmenarchal daughters of women with polycystic ovary syndrome.

Fertil Steril 2018 Dec 6. Epub 2018 Dec 6.

Endocrinology and Metabolism Laboratory, West Division, School of Medicine, University of Chile, Santiago, Chile.

Objective: To study the reproductive and metabolic differences between daughters of women with polycystic ovary syndrome (PCOSd) and control women (Cd) after menarche.

Design: Case-control study.

Setting: Clinical endocrinology unit. Read More

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December 2018

Minimal difference in phenotype between adolescents and young adults with polycystic ovary syndrome.

Fertil Steril 2018 Dec 6. Epub 2018 Dec 6.

Department of Obstetrics and Gynecology, University of California, Los Angeles, California; Department of Obstetrics and Gynecology, Augusta University, Augusta, Georgia; Department of Reproductive Health Protection, Scientific Center of Family Health and Human Reproduction, Irkutsk, Russian Federation; Department of Health Policy, Management, and Behavior, School of Public Health, State University of New York, Albany, New York. Electronic address:

Objective: To test the hypothesis that the polycystic ovary syndrome (PCOS) phenotype, or its component features, is less severe in adolescents than in young adult patients, in a referred (clinical) population.

Design: Cross-sectional study.

Setting: Tertiary-care academic medical center. Read More

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December 2018

[Green mamba venom, a therapeutic promise in polycystic kidney disease].

Med Sci (Paris) 2018 Nov 10;34(11):1006-1008. Epub 2018 Dec 10.

Institut des sciences du vivant Frédéric Joliot, CEA Saclay, 91190 Gif sur Yvette, France.

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November 2018

Early onset of graft glomerulopathy in a patient with post-transplant diabetes mellitus after renal transplantation: a case report.

BMC Nephrol 2018 Dec 7;19(1):348. Epub 2018 Dec 7.

Nephrology, Dialysis and Renal Transplant Unit, IRCCS Policlinico San Matteo Foundation, P.le Golgi 19, 27100, Pavia, Italy.

Background: Post-transplant diabetes mellitus (PTDM) is an emerging problem in kidney transplantation, representing an important risk factor for kidney function loss. Diabetic nephropathy (DN) occurrence in transplanted kidneys is poorly investigated. Current knowledge describes DN recurrence in graft 5. Read More

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December 2018

Erratum. Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome.

Hum Reprod 2018 Dec 6. Epub 2018 Dec 6.

National Health and Medical Research Council Centre for Research Excellence in PCOS, Monash University, Melbourne, Victoria, Australia.

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December 2018
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Effect of sex hormone-binding globulin polymorphisms on the outcome of in vitro fertilization-embryo transfer for polycystic ovary syndrome patients: A case-control study.

J Cell Biochem 2018 Dec 5. Epub 2018 Dec 5.

Department of Gynecology, Linyi People's Hospital, Linyi, China.

Polycystic ovary syndrome (PCOS), known as a common endocrine disorder among females, plagues many PCOS patients. The current study aimed to explore the correlations of sex hormone-binding globulin (SHBG) polymorphisms with the outcome of in vitro fertilization-embryo transfer (IVF-ET) in PCOS patients. PCOS patients who underwent IVF-ET and patients with non-PCOS-related infertility were selected in the study. Read More

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December 2018
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Estimated GFR: time for a critical appraisal.

Nat Rev Nephrol 2018 Dec 5. Epub 2018 Dec 5.

Nephrology and Dialysis Unit, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy.

Since 1957, over 70 equations based on creatinine and/or cystatin C levels have been developed to estimate glomerular filtration rate (GFR). However, whether these equations accurately reflect renal function is debated. In this Perspectives article, we discuss >70 studies that compared estimated GFR (eGFR) with measured GFR (mGFR), involving ~40,000 renal transplant recipients and patients with chronic kidney disease (CKD), type 2 diabetes mellitus or polycystic kidney disease. Read More

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December 2018

Polycystosis of the renal sinus or polycystic kidney disease Controversies, challenges and history of a shared discovery.

Actas Urol Esp 2018 Dec 6;42(10):645-648. Epub 2018 Jul 6.

Servicio de Urología, Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Madrid, España.

Objective: To recall the history of the discovery of non-nephron cystic disease, detected simultaneously in 2 hospitals in Madrid, and the vicissitudes that the authors endured during the process of recognising this disease, while being ignored by the international scientific literature.

Material And Method: We analysed the authors' first publications and presentations, their correspondence relaying the difficulties in reporting the confusion with adult polycystic kidney disease (APKD) and the subsequent nosological identification of the process. We consulted with individuals who worked with the 2 authors to increase the accuracy and objectivity of the history report. Read More

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December 2018

Downregulation of Extracellular Matrix and Cell Adhesion Molecules in Cumulus Cells of Infertile Polycystic Ovary Syndrome Women with and without Insulin Resistance.

Cell J 2019 Jan 18;21(1):35-42. Epub 2018 Nov 18.

Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.

Objective: The extracellular matrix (ECM) of the cumulus oocyte complex (COC) is composed of several molecules that have different roles during follicle development. This study aims to explore gene expression profiles for ECM and cell adhesion molecules in the cumulus cells of polycystic ovary syndrome (PCOS) patients based on their insulin sensitivity following controlled ovarian stimulation (COS).

Materials And Methods: In this prospective case-control study enrolled 23 women less than 36 years of age who participated in an intracytoplasmic sperm injection (ICSI) program. Read More

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January 2019

Clinical Manifestation, Management and Prognosis of Acute Myocardial Infarction in Autosomal Dominant Polycystic Kidney Disease.

Kidney Blood Press Res 2018 Nov 30;43(6):1806-1812. Epub 2018 Nov 30.

Background/aims: Cardiovascular complications are the most common cause of death in individuals with autosomal dominant polycystic kidney disease (ADPKD), yet there is no substantial data concerning the clinical characteristics of acute myocardial infarction (AMI) in this population. This study thus aimed to investigate AMI in persons with ADPKD.

Methods: A retrospective analysis of ADPKD patients admitted to our hospital over a 13 year period was conducted. Read More

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November 2018

Altered Hepatobiliary Disposition of Tolvaptan and Selected Tolvaptan Metabolites in a Rodent Model of Polycystic Kidney Disease.

Drug Metab Dispos 2018 Nov 30. Epub 2018 Nov 30.

UNC Eshelman School of Pharmacy;

Tolvaptan, a vasopressin V2-receptor antagonist, has demonstrated efficacy in slowing kidney function decline in patients with autosomal dominant polycystic kidney disease (ADPKD). In the pivotal clinical trial, the incidence of elevated liver enzymes was higher in patients receiving tolvaptan compared to placebo. Adjudication by a panel of expert hepatologists concluded a causal link of tolvaptan to liver injury in patients with ADPKD. Read More

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November 2018

Sex, Microbes, and Polycystic Ovary Syndrome.

Trends Endocrinol Metab 2018 Nov 29. Epub 2018 Nov 29.

Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Diego, La Jolla, CA, 92093, USA; http://repro.ucsd.edu/thackray. Electronic address:

Recent studies have shown that sex and sex steroids influence the composition of the gut microbiome. These studies also indicate that steroid regulation of the gut microbiome may play a role in pathological situations of hormonal excess, such as PCOS. Indeed, studies demonstrated that PCOS is associated with decreased alpha diversity and changes in specific Bacteroidetes and Firmicutes, previously associated with metabolic dysregulation. Read More

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November 2018

Cardiometabolic risks in polycystic ovary syndrome: long-term population-based follow-up study.

Fertil Steril 2018 Dec;110(7):1377-1386

Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Objective: To evaluate the incidence of hypertension, metabolic syndrome, dyslipidemia, and obesity in comparing women with polycystic ovary syndrome (PCOS) and a control group of healthy women.

Design: Prospective cohort study with the median and interquartile range of 12.9 (10. Read More

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December 2018

Precocious subcutaneous abdominal stem cell development to adipocytes in normal-weight women with polycystic ovary syndrome.

Fertil Steril 2018 Dec;110(7):1367-1376

Department of Obstetrics and Gynecology, University of California-Los Angeles, Los Angeles, California. Electronic address:

Objective: To examine whether abnormal subcutaneous (SC) abdominal adipose stem cell (ASC) development to adipocytes in polycystic ovary syndrome (PCOS) correlates with hyperandrogenism.

Design: Prospective cohort study.

Setting: Academic medical center. Read More

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December 2018

Age at onset of metabolic syndrome among women with and without polycystic ovary syndrome-like status.

J Clin Endocrinol Metab 2018 Dec 3. Epub 2018 Dec 3.

Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.

Context: Women with polycystic ovary syndrome (PCOS) have a higher prevalence of metabolic syndrome (MetS), but whether they develop MetS earlier than women without PCOS is unknown. Understanding the impact of PCOS on the timing of MetS onset is important for screening and clinical care in this population.

Design: Women with PCOS-like status ("PCOSp") were identified from participants of the Michigan Bone Health and Metabolism Study based upon history of irregular menstrual cycles, high free-androgen index and high levels of anti-müllerian hormone. Read More

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December 2018
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Infected cyst in patients with autosomal dominant polycystic kidney disease: Analysis of computed tomographic and ultrasonographic imaging features.

PLoS One 2018 5;13(12):e0207880. Epub 2018 Dec 5.

Department of Radiology, Seoul National University Hospital, Seoul, Korea.

Purpose: To investigate the imaging features of cyst infection in autosomal dominant polycystic kidney disease (ADPKD) patients using computed tomography (CT) and ultrasonography (US).

Materials & Methods: The institutional review board approved this retrospective study. Fifty-one episodes with proven cyst infection in forty-three ADPKD patients were included. Read More

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December 2018

Socioeconomic status in Danish women with polycystic ovary syndrome. A register-based cohort study.

Acta Obstet Gynecol Scand 2018 Dec 5. Epub 2018 Dec 5.

Department of Endocrinology, Odense University Hospital, Odense, Denmark.

Introduction: Low socioeconomic status (SES) could be associated with increased risk of polycystic ovary syndrome (PCOS) and vice versa. Possible associations between SES, obesity, and ethnicity in PCOS are undetermined MATERIAL AND METHODS: National register-based study including women with PCOS aged 25 years or above (PCOS Denmark and an embedded cohort; PCOS Odense University Hospital (OUH)) and one control population. PCOS Denmark (N=13,891) included women with PCOS in the Danish National Patient Register. Read More

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December 2018

Effect of DNA damage of cumulus oophorus cells and lymphocytes analyzed by alkaline comet assay on oocyte quality and intracytoplasmic sperm injection success among patients with polycystic ovary syndrome.

J Obstet Gynaecol Res 2018 Dec 4. Epub 2018 Dec 4.

Department of Obstetrics and Gynaecology, in vitro Fertilization Unit, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey.

Aim: Cumulus oophorus cells (COC) exhibit a close relationship with the oocytes. We aimed to determine the role of the DNA integrity of COC and lymphocytes on the oocyte and embryo quality and intracytoplasmic sperm injection (ICSI) success.

Methods: The COC obtained with the mechanical denudation of each oocyte and the lymphocytes obtained on oocyte retrieval day from 69 infertile polycystic ovary syndrome (PCOS) patients were used. Read More

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December 2018
1 Read

Effects of dipeptidyl peptidase-4 inhibitors on transforming growth factor-β1 signal transduction pathways in the ovarian fibrosis of polycystic ovary syndrome rats.

J Obstet Gynaecol Res 2018 Dec 4. Epub 2018 Dec 4.

Department of Gynecology, The Affiliated Hangzhou Hospital of Nanjing Medical University, Hangzhou, Zhejiang, China.

Aim: Examine the effects of dipeptidyl peptidase-4 (DPP4) inhibitor Sitagliptin on the transforming growth factor-β1 (TGF-β1) signal transduction pathway in polycystic ovary syndrome (PCOS) rats with ovarian fibrosis.

Methods: Thirty rats were divided randomly into the PCOS model group, Sitagliptin treatment group and blank control group. Dehydroepiandrosterone was administered to the model group and treatment group to establish the models. Read More

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December 2018
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The Combination of Metformin and 2-deoxyglucose Significantly Inhibits Cyst Formation in Miniature Pigs with Polycystic Kidney Disease.

Br J Pharmacol 2018 Dec 4. Epub 2018 Dec 4.

Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Diseases, Beijing, 100853, China.

Background And Purpose: The pathogenic mechanism of autosomal dominant polycystic kidney disease (ADPKD) is unclear. Similar to tumor cells, polycystic kidney cells are primarily dependent on aerobic glycolysis for ATP production. Compared with rodents, miniature pigs are more similar to humans. Read More

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December 2018

A comprehensive interventional program for promoting eating behaviors in adolescent girls with polycystic ovarian syndrome (PCOS): protocol for a mixed methods study.

Reprod Health 2018 Dec 4;15(1):197. Epub 2018 Dec 4.

Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder among women. Inappropriate eating behaviors are some of the most important risk factors for obesity in all age groups. Therefore, performing comprehensive culturally sensitive interventions for modification of eating behaviors as a useful affordable strategy seems necessary. Read More

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December 2018

The Healing-Promoting Properties of Selected Cyclitols-A Review.

Nutrients 2018 Dec 3;10(12). Epub 2018 Dec 3.

Department of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Nicolaus Copernicus University, 87-100 Torun, Poland.

Introduction: -inositol and its derivatives cyclitols play an important role in the processes of cell regulation, signal transduction, osmoregulation, and ion channel physiology, and are a component of the cell membrane. Free cyclitols present in food or released during the degradation of galactosyl cyclitols by bacteria (in digestive tract) show some physiological benefits.

Aim: The aim of this paper is to present and analyze the documented data about curative and healing properties of cyclitols. Read More

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December 2018
2 Reads

Metabolic Syndrome and Insulin Resistance Syndrome among Infertile Women with Polycystic Ovary Syndrome: A Cross-Sectional Study from Central Vietnam.

Endocrinol Metab (Seoul) 2018 Dec;33(4):447-458

Department of Obstetrics and Gynecology, Hue University of Medicine and Pharmacy, Hue University, Hue City, Vietnam.

Background: Polycystic ovarian syndrome (PCOS) is one of the most common endocrinopathies among reproductive-age women. Its metabolic features often overlap with those associated with metabolic syndrome (MS) and insulin resistance syndrome (IRS). The objective of this study was to determine the prevalence and predictors of MS and IRS in infertile Vietnamese women with PCOS. Read More

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December 2018
5 Reads

Factors Influencing Cyst Infection in Autosomal Dominant Polycystic Kidney Disease.

Nephron 2018 Dec 4:1-12. Epub 2018 Dec 4.

Department of Nephrology, Toranomon Hospital, Tokyo, Japan.

Background: Cyst infection is a frequent and serious complication of autosomal dominant polycystic kidney disease (ADPKD) that is often difficult to treat. However, the factors influencing cyst infection are still unknown. Therefore, we investigated clinical factors related to the duration of hospitalization and death due to cyst infection. Read More

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December 2018
5 Reads

Vitamin D and metabolic disturbances in polycystic ovary syndrome (PCOS): A cross-sectional study.

PLoS One 2018 4;13(12):e0204748. Epub 2018 Dec 4.

Department of Internal Medicine/Endocrinology, VU University Medical Center, Amsterdam, The Netherlands.

Objective: To compare vitamin D status in women with PCOS versus fertile women and subsequently evaluate the association between vitamin D status and metabolic disturbances in PCOS women.

Methods: We conducted a cross-sectional comparison study of 639 women with PCOS and 449 fertile women. Serum 25-hydroxyvitamin D (25(OH)D) was stratified into a severe deficient (< 25 nmol/l), insufficient (25-50 nmol/l), moderate (50-75 nmol/l) and adequate (> 75 nmol/l) status. Read More

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December 2018
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Gynaecological cancers and leptin: A focus on the endometrium and ovary.

Facts Views Vis Obgyn 2018 Mar;10(1):5-18

Ovarian Cancer Laboratory, Veterans Affairs Medical Center, Kansas City, MO 64128, United States.

Obesity has an influence on the risk and prognosis of different types of cancers of the female reproductive tract. In the uterus, a common site for neoplasms is the endometrium, the inner lining tissue. Generally, obesity has been documented to be involved in endometrioid carcinoma of the endometrium. Read More

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March 2018
3 Reads

Therapeutic Use of mTOR Inhibitors in Renal Diseases: Advances, Drawbacks, and Challenges.

Oxid Med Cell Longev 2018 29;2018:3693625. Epub 2018 Oct 29.

Laboratory of Pharmacology & Experimental Therapeutics, Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, CNC.IBILI Consortium & CIBB Consortium, University of Coimbra, 3000-548 Coimbra, Portugal.

The mammalian (or mechanistic) target of rapamycin (mTOR) pathway has a key role in the regulation of a variety of biological processes pivotal for cellular life, aging, and death. Impaired activity of mTOR complexes (mTORC1/mTORC2), particularly mTORC1 overactivation, has been implicated in a plethora of age-related disorders, including human renal diseases. Since the discovery of rapamycin (or sirolimus), more than four decades ago, advances in our understanding of how mTOR participates in renal physiological and pathological mechanisms have grown exponentially, due to both preclinical studies in animal models with genetic modification of some mTOR components as well as due to evidence coming from the clinical experience. Read More

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October 2018
1 Read

Prenatal MR imaging features of Caroli syndrome in association with autosomal recessive polycystic kidney disease.

Radiol Case Rep 2019 Feb 26;14(2):265-268. Epub 2018 Nov 26.

Department of Radiology, The Children's Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 10104, USA.

Caroli syndrome, which is characterized by saccular and fusiform dilatation of the biliary ducts, is usually observed in association with autosomal recessive polycystic kidney disease (ARPKD). Although the diagnosis of ARPKD is generally easy to make in postnatal ultrasound, the diagnosis of Caroli syndrome may be challenging in prenatal ultrasound. Herein, we present a case of a 29-week fetus with ARPKD associated with Caroli syndrome in whom fetal magnetic resonance imaging was essential to identify the "central dot sign" within the dilated biliary ducts to confirm the prenatal diagnosis of Caroli syndrome and to increase our level of confidence in this diagnosis. Read More

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February 2019
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Left ventricular dysfunction in ADPKD and effects of octreotide-LAR: A cross-sectional and longitudinal substudy of the ALADIN trial.

Int J Cardiol 2019 Jan 22;275:145-151. Epub 2018 Oct 22.

IRCCS - Istituto di Ricerche Farmacologiche "Mario Negri", Clinical Research Centre for Rare Diseases "Aldo e Cele Daccò", Bergamo, Italy; Unit of Nephrology and Dialysis, Azienda Socio-Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy.

Background And Aim: In autosomal dominant polycystic kidney disease (ADPKD) cardiac abnormalities have been observed before the onset of hypertension or renal dysfunction. We sought to characterize, in ADPKD patients, left ventricular (LV) function and its changes after somatostatin-analogue octreotide-LAR treatment.

Methods: In a 1:1:1 cross-sectional study, we evaluated LV function by speckle-tracking echocardiography in 34 ADPKD patients from one ALADIN-trial center and in 34 age- and gender-matched healthy controls and 34 equally-matched renal controls with non-cystic chronic kidney disease. Read More

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January 2019

Effects of ADIPOQ polymorphisms on PCOS risk: a meta-analysis.

Reprod Biol Endocrinol 2018 Dec 3;16(1):120. Epub 2018 Dec 3.

Department of gynaecology, Linyi Central Hospital, No.17 Jiankang Road of Yishui county, Linyi, 276400, Shandong, China.

Background: Whether adiponectin (ADIPOQ) polymorphisms are associated with the risk of polycystic ovary syndrome (PCOS) remain controversial. Therefore, we performed this study to better explore correlations between ADIPOQ polymorphisms and PCOS risk.

Methods: Literature retrieve was conducted in PubMed, Medline and Embase. Read More

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December 2018
1 Read

Managing polycystic ovary syndrome in primary care.

Singapore Med J 2018 Nov;59(11):567-571

Department of Endocrinology, Changi General Hospital, Singapore.

Polycystic ovary syndrome (PCOS) presents with a spectrum of conditions resulting from androgen excess, anovulation and metabolic syndrome. Patients with PCOS may see their primary care physicians for various presentations, including hirsutism, acne, menstrual irregularities, infertility, obesity, and psychiatric disorders such as anxiety and depression. Management of these patients should include screening for Type 2 diabetes mellitus, dyslipidaemia and hypertension. Read More

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November 2018
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ATF4 Contributes to Ovulation via Regulating COX2/PGE2 Expression: A Potential Role of ATF4 in PCOS.

Front Endocrinol (Lausanne) 2018 15;9:669. Epub 2018 Nov 15.

Center for Reproductive Medicine, School of Medicine, Ren Ji Hospital, Shanghai Jiao Tong University, Shanghai, China.

Ovulatory disorder is common in patients with hyperprolactinemia or polycystic ovary syndrome (PCOS). Previous studies have shown that ATF4 plays critical role in apoptosis and glucose homeostasis, but its role in regulating reproductive function was not explored. The present study investigated the role of ATF4 in ovarian ovulatory function. Read More

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November 2018

Ruptured intracranial aneurysm in a patient with autosomal recessive polycystic kidney disease.

Authors:

J Neurosurg Pediatr 2018 Oct 1:1-5. Epub 2018 Oct 1.

Aneurysmal rupture can result in devastating neurological consequences and can be complicated by comorbid disease processes. Patients with autosomal recessive polycystic kidney disease (ARPKD) have a low rate of reported aneurysms, but this may be due to the relative high rate of end-stage illnesses early in childhood. Authors here report the case of a 10-year-old boy with ARPKD who presented with a Hunt and Hess grade V subarachnoid hemorrhage requiring emergency ventriculostomy, embolization, and decompressive craniectomy. Read More

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October 2018
3 Reads

Bidirectional Mendelian randomization to explore the causal relationships between body mass index and polycystic ovary syndrome.

Hum Reprod 2018 Nov 29. Epub 2018 Nov 29.

Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Study Question: What are the causal relationships between polycystic ovary syndrome (PCOS) and body mass index (BMI)?

Summary Answer: Bidirectional Mendelian randomization analyses suggest that increased BMI is causal for PCOS while the reverse is not the case.

What Is Known Already: The contribution of obesity to the pathogenesis of PCOS is controversial. To date, published genetic studies addressing this question have generated conflicting results and have not utilized the full extent of known single nucleotide polymorphisms associated with body mass index (BMI). Read More

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November 2018
1 Read

Association Between Polycystic Ovary Syndrome and Cancer Risk.

JAMA Oncol 2018 Nov 29. Epub 2018 Nov 29.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

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November 2018
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Weight restoration in atypical anorexia nervosa: A clinical conundrum.

Int J Eat Disord 2018 Nov 28. Epub 2018 Nov 28.

Division of Adolescent and Young Adult Medicine, Department of Pediatrics, University of California, San Francisco, California.

The determination of the treatment goal weight for adolescents with a restrictive eating disorder (ED) and a prior history of obesity, such as in atypical anorexia nervosa (AAN), represents an ongoing challenge for clinicians. This determination is particularly complex given competing interests of physical recovery from significant weight loss, mental recovery from ED psychopathology, and the medical comorbidities associated with obesity. We report the case of a 15-year old female with a history of obesity and irregular periods who presented with significant weight loss and absence of menses for 3 months. Read More

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November 2018
2 Reads

Vitamin D Status in Polycystic Ovarian Syndrome Patients Attending a Tertiary Hospital of Bangladesh.

Mymensingh Med J 2018 Oct;27(4):730-736

Dr Abul Bashar Mohammad Kamrul Hasan, Assistant Registrar, Department of Endocrinology, Mymensingh Medical College Hospital (MMCH), Mymensingh, Bangladesh; E-mail: rangassmc@ gmail.com.

Vitamin D deficiency is common in patients with polycystic ovarian syndrome (PCOS) and found to have multiple impacts on the disease process. Vitamin D status of women with or without PCOS in Bangladesh is largely unknown. This cross-sectional study was conducted in a tertiary level hospital of Bangladesh from January 2018 to April 2018 to address this lacuna. Read More

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October 2018

The Roles of Primary Cilia in Cardiovascular Diseases.

Cells 2018 Nov 27;7(12). Epub 2018 Nov 27.

Department of Biomedical & Pharmaceutical Sciences, Harry and Diane Rinker Health Science Campus, Chapman University, 9401 Jeronimo Road, Irvine, CA 92618-1908, USA.

Primary cilia are microtubule-based organelles found in most mammalian cell types. Cilia act as sensory organelles that transmit extracellular clues into intracellular signals for molecular and cellular responses. Biochemical and molecular defects in primary cilia are associated with a wide range of diseases, termed ciliopathies, with phenotypes ranging from polycystic kidney disease, liver disorders, mental retardation, and obesity to cardiovascular diseases. Read More

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November 2018
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Periostin and polycystic kidney disease: more pieces in the puzzle.

Am J Physiol Renal Physiol 2018 Nov 28. Epub 2018 Nov 28.

Medicine, University of Sao Paulo School of Medicine, Brazil, Brazil.

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November 2018

Expression of FKBP52 in the ovaries of PCOS rats.

Int J Mol Med 2018 Nov 26. Epub 2018 Nov 26.

Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, P.R. China.

The present study aimed to examine the expression of FK‑506 binding protein 52 (FKBP52) in the ovary tissues of rats with polycystic ovarian syndrome (PCOS) and its action on mediating androgen receptor (AR) through the mitogen‑activated protein kinase (MAPK)/extracellular signal‑regulated kinase (ERK) pathway. PCOS model rats were established by dehydroepiandrosterone injection. Enzyme‑linked immunosorbent assay (ELISA) measured serum sex hormones. Read More

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November 2018

In vitro maturation in subfertile women with polycystic ovarian syndrome undergoing assisted reproduction.

Cochrane Database Syst Rev 2018 11 15;11:CD006606. Epub 2018 Nov 15.

Assisted Reproduction Unit, 3rd Department of Obstetrics and Gynaecology, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, Rimini 1, Athens, Chaidari, Greece, 12462.

Background: Polycystic ovarian syndrome (PCOS) occurs in 4% to 7% of all women of reproductive age and 50% of women presenting with subfertility. Subfertility affects 15% to 20% of couples trying to conceive. A significant proportion of these women ultimately need assisted reproductive technology (ART). Read More

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November 2018
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