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J Clin Rheumatol 2019 Jan 4. Epub 2019 Jan 4.

Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi 783-8505, Japan Laboratory of Anatomy, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita-Ku, Sapporo, 060-0818, Japan. Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi 783-8505, Japan.

World J Otorhinolaryngol Head Neck Surg 2018 Dec 17;4(4):234-239. Epub 2018 Oct 17.

Department of ENT, Sur Hospital, South Sharqiya Region. Sur, Oman.

Background And Objectives: An auricular pseudocyst is not uncommon in routine ENT clinical practice, it occurs when fluid accumulates between the intracartilaginous spaces of the auricle. Many treatment modalities have been proposed such as incision and drainage of the cyst, simple needle aspiration, tight bandaging with dental rolls, however recurrence and cosmetic problems are still noted in some cases. The aim of this article was to discuss our experience of surgical treatment of intractable auricular pseudocysts with marsupialisation, deroofing and anterior cartilage leaflet removal along with compression suture therapy. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Oct;32(19):1509-1510

Joint Bone Spine 2018 Nov 15. Epub 2018 Nov 15.

Service de rhumatologie, centre de référence des maladies autoimmunes systemiques rares Est Sud-Ouest (RESO), hôpital de Hautepierre, 1, avenue Molière BP 83049, 67098 Strasbourg cedex, France; Inserm UMR-S1109, 67098 Strasbourg cedex, France. Electronic address:

Objectives: Relapsing polychondritis is a rare, multi-systemic and inflammatory condition of unknown origin. We currently lack a core set of measures to assess and follow damage in patients suffering from this condition. Our primary aim was to derive a disease-specific damage measuring tool for relapsing polychondritis, the Relapsing Polychondritis Damage Index (RPDAM). Read More

J Int Med Res 2018 Nov 14:300060518805593. Epub 2018 Nov 14.

1 Department of Neurology, Tianjin HuanHu Hospital, Tianjin, China.

Relapsing polychondritis (RP) is a rare autoimmune disorder affecting cartilage. Limbic encephalitis is a rare central nervous system manifestation of RP. This current case report describes a 66-year-old Chinese male patient who complained of developing myoclonus in the left leg, ataxia and speech difficulties 3 weeks prior to hospital admission. Read More

Pract Neurol 2018 Nov 13. Epub 2018 Nov 13.

Department of Clinical Neurosciences, Western General Hospital, Edinburgh, UK.

A 65-year-old man presented with transient neurological symptoms, followed by rapid cognitive decline, myoclonus and fevers. He had evidence of scleritis and an arthropathy. This paper reports the clinicopathological conference discussed at the Association of British Neurologists Annual Meeting 2017. Read More

Case Rep Neurol Med 2018 3;2018:1873582. Epub 2018 Oct 3.

Clinical Assistant Professor, University of Illinois College of Medicine at Peoria, Peoria, IL, USA.

Meningoencephalitis is a rare complication of relapsing polychondritis. We report a case of a 25-year-old male who presented with visual hallucinations and symptoms of depression and anxiety, white matter changes on MRI, and CSF lymphocytosis, along with inflammatory chondritis seen in his auricle cartilage biopsy. Eventually he was given the diagnosis of RP presenting with meningoencephalitis based on CSF analysis, brain MRI findings, negative serologies, and neurologic exam findings. Read More

RMD Open 2018 18;4(Suppl 1):e000788. Epub 2018 Oct 18.

Service de rhumatologie, Hôpitaux Universitaires de Strasbourg, Centre National de Référence des Maladies Systémiques et Auto-immunes Rares (RESO), INSERM-UMRS 1109, F-67000, Strasbourg, France.

Due to the rarity of relapsing polychondritis (RP), many unmet needs remain in the management of RP. Here, we present a systematic review of clinical practice guidelines (CPGs) published for RP, as well as a list of the most striking unmet needs for this rare disease. We carried out a systematic search in PubMed and Embase based on controlled terms (medical subject headings and Emtree) and keywords of the disease and publication type (CPGs). Read More

Sichuan Da Xue Xue Bao Yi Xue Ban 2018 Sep;49(5):803-807

Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu 610041, China.

Objective: To analyze the characteristics of clinical manifestation, imaging, fiber-bronchoscope finding and pulmonary function testing in the patients of relapsing polychodriti with respiratory symptoms.

Methods: The clinical data of 33 patients with RP in West China Hospital of Sichuan University from May 2007 to May 2017 were analyzed retrospectively. The patients were divided into respiratory group (21 cases) and non-respiratory group (12 cases) based on whether the respiratory symptoms were main involvement, and the data of the two groups were statistically analyzed. Read More

J Immunol Res 2018 26;2018:5072582. Epub 2018 Sep 26.

Department of Neurosciences, Otorhinolaryngology Unit, University of Padua, Via Giustiniani, 2, 35128 Padova, Italy.

The prevalence of autoimmune diseases has been increasing over the last 20 years. The clinical presentation of this large and heterogeneous group of disorders depends on whether the involvement is organ-specific or non-organ-specific. Dizziness, vertigo, and disequilibrium are common symptoms reported by patients with vestibulocochlear involvement. Read More

Am J Ophthalmol 2018 Oct 20. Epub 2018 Oct 20.

Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, Portland, OR, USA; Department of Medicine, Oregon Health & Science University, Portland, OR. USA; Legacy Devers Eye Institute, Legacy Health System, Portland, OR. USA. Electronic address:

Purpose: Idiopathic uveitis is frequently the most common diagnosis in series from uveitis clinics. We sought to determine the percentage of patients initially diagnosed as idiopathic, non-infectious uveitis referred to a tertiary uveitis center who were subsequently found to have an identifiable cause of uveitis.

Design: Retrospective case series. Read More

Medicine (Baltimore) 2018 Oct;97(42):e12837

Department of Immunology and Medicine, Institute of Medical Science, and Division of Rheumatology and Allergology, St. Marianna University School of Medicine, Kawasaki, Japan.

Relapsing polychondritis (RP) is a multisystem disorder of cartilaginous tissues. Previously, we found that patients with respiratory involvement and patients with auricular involvement were mutually exclusive in the RP cohort, which suggests a strong inverse relationship between respiratory and auricular involvement. Here, we examined the clinical manifestation patterns in a subgroup of patients with respiratory involvement (R subgroup) and a subgroup of patients with auricular involvement (A subgroup) and investigated the clinical and laboratory characteristics of each subgroup. Read More

Br J Ophthalmol 2018 Oct 12. Epub 2018 Oct 12.

University Eye Clinic Maastricht, Maastricht, The Netherlands.

Purpose: To characterise the ocular and extraocular findings in patients with relapsing polychondritis (RP) patients.

Design: Retrospective, longitudinal study.

Methods: A total number of 16 patients with ocular RP, seen in our tertiary uveitis referral centre over a time period of 10 years were included in this study. Read More

Medicine (Baltimore) 2018 Oct;97(40):e12716

Department of Rheumatology and Immunology, Xiangya Hospital.

Rationale: Relapsing polychondritis (RP) is a rare autoimmune-related disease and may be associated with other autoimmune diseases.

Patient Concerns: Here we reported a case of RP patients with mixed-type AIHA. The patient was diagnosed with RP in March 2008 which was treated and the patient was in stable condition. Read More

PLoS One 2018 20;13(9):e0203657. Epub 2018 Sep 20.

Department of Immunology and Medicine, St. Marianna University School of Medicine, Kawasaki, Japan.

Relapsing polychondritis (RP) is an inflammatory disease of unknown causes, characterized by recurrent inflammation in cartilaginous tissues of the whole body. Recently, researchers have reported that, in mouse experiments, altered gut microbe-dependent T cell differentiation occurred in gut associated lymphoid tissues. Here, we investigated whether gut microbe alteration existed, and if so, the alteration affected peripheral T cell differentiation in patients with RP. Read More

Ocul Immunol Inflamm 2018 Sep 7:1-3. Epub 2018 Sep 7.

a Eye Research Center , Mashhad University of Medical Sciences , Mashhad , Iran.

Purpose: To report a rare case of relapsing polychondritis with bilateral panuveitis as the first presentation of systemic disease Methods: A 26-year-old female presented with bilateral decreased vision, red eye and ocular pain underwent complete ocular examination, retinal imaging and systemic investigation.

Results: Investigations revealed bilateral panuveitis associated with keratitis, retinal hemorrhages and retinal vasculitis. Following systemic work-ups and the pinna cartilage biopsy, diagnosis of relapsing polychondritis was made. Read More

Rom J Morphol Embryol 2018 ;59(2):595-599

Department of Otorhinolaryngology, "Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania;

Giant cell arteritis (GCA) is a large-vessel vasculitis with rarely described respiratory initial manifestations. We report such a case presenting with hoarseness, stridor, cough and dyspnea, in which a tracheomegaly with tracheomalacia was found. No signs of relapsing polychondritis were present. Read More

Cent Eur J Immunol 2018 30;43(2):132-138. Epub 2018 Jun 30.

Department of Histology and Embryology, Medical University of Warsaw, Poland.

The purpose of this work was to establish, whether rat chondrocyte associated antigen, transmembrane Tmp21 protein belonging to the p24 protein family may immunize rats and thus be included into the panel of immunogens potentially involved in cartilage pathology. For immunization of rats extract from cultured chondrocytes containing surface chondrocyte proteins suspended in incomplete Freund's adjuvant was used. Control animals were injected with incomplete Freund's adjuvant without chondrocyte extract. Read More

J Clin Rheumatol 2018 Aug 13. Epub 2018 Aug 13.

Department of Radiology, Landstuhl Regional Medical Center, Landstuhl, Germany.

Rheumatol Int 2018 Nov 6;38(11):2095-2101. Epub 2018 Aug 6.

Department of Rheumatology and Clinical Immunology, Charité Universitätsmedizin Berlin, Chariteplatz 1, 10117, Berlin, Germany.

Observational study of patients with relapsing polychondritis (RPC) and brief evaluation of widely used diagnostic criteria. A retrospective analysis of 18 patients with RPC treated in the past 15 years at the Charté-Universitätsmedizin Berlin was performed. Three different diagnostic criteria were applied to our cohort. Read More

Biomedicines 2018 Aug 2;6(3). Epub 2018 Aug 2.

Department of Clinical and Experimental Medicine, Section of Dermatology, University of Messina, 98125 Messina, Italy.

Relapsing polychondritis is an immune-mediated systemic disease characterized by recurrent episodes of inflammation of cartilaginous and proteoglycan-rich tissues, resulting in progressive anatomical deformation and functional impairment of the involved structures. Auricular and nasal chondritis and/or polyarthritis represent the most common clinical features, but potentially all types of cartilage may be involved. Because of the pleomorphic nature of the disease, with non-specific symptoms at the onset, the diagnosis of relapsing polychondritis is often delayed. Read More

Case Rep Rheumatol 2018 2;2018:6760806. Epub 2018 Jul 2.

University of Michigan Medical School, Ann Arbor, MI, USA.

Relapsing polychondritis (RP) is an autoimmune disorder that often occurs concomitantly with other autoimmune diseases, though RP has been infrequently associated with ankylosing spondylitis (AS). There is a small, but growing, body of the literature demonstrating case reports describing RP secondary to AS in patients treated with tumor necrosis alpha inhibitors (TNFi's). We present the first case in which RP developed in AS while treated with an interleukin 17A inhibitor (IL-17Ai), secukinumab. Read More

Am J Ophthalmol Case Rep 2018 Sep 20;11:3-5. Epub 2018 Apr 20.

Department of Ophthalmology, Nara Medical University, Kashihara, 634-8522 Nara, Japan.

Purpose: Relapsing polychondritis is a rare multiorgan disease characterized by repeated episodes of inflammation and deterioration of cartilages. We report a case of relapsing polychondritis that presented with severe panuveitis.

Observations: A 53-year-old man visited our hospital because of ocular pain in both eyes of 2 weeks' duration. Read More

Clin Dermatol 2018 Jul - Aug;36(4):525-532. Epub 2018 Apr 10.

Department of Dermatology, University of California-San Diego School of Medicine, San Diego, California, USA. Electronic address:

The cutaneous manifestations of the common rheumatologic disorders, such as systemic lupus erythematosus, dermatomyositis, and systemic sclerosis, are well known. In contrast, the dermatologic findings of less common rheumatologic disorders, including Sjögren syndrome, mixed connective tissue disease, and relapsing polychondritis, are less widely known. The cutaneous manifestations of these connective tissue disorders are reviewed. Read More

Can Fam Physician 2018 Jul;64(7):488

Victoria, BC.

Otolaryngol Pol 2018 Jun;72(3):26-32

Department of Plastic and Reconstructive Surgery, Addenbrooke's University Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK Postgraduate Medical Institute, Faculty of Medical Sciences, Anglia Ruskin University, Cambridge & Chelmsford, UK.

Introduction We present a single surgeon's experience of open augmentation rhinoplasty with autogenous L-shaped costal cartilage grafts, with long-term patient-reported outcome data. We highlight the salient operative steps and outline the peri-operative care required to optimise outcomes. Materials and Methods A retrospective review of eleven such augmentation rhinoplasties performed between 2008 and 2016 was undertaken. Read More

J Clin Med Res 2018 Aug 27;10(8):609-614. Epub 2018 Jun 27.

Department of Gastroenterology, Medical School of Ioannina, Ioannina, Greece.

Inflammatory bowel disease (IBD) is a multisystemic disease. The ear is a rare but recognized site of extraintestinal manifestations of IBD. In external ear, the more common manifestations of IBD are pyoderma gangrenosum, metastatic Crohn's disease and relapsing polychondritis and the treatment includes corticosteroids and anti-TNF agents. Read More

Matrix Biol 2018 10 24;71-72:51-69. Epub 2018 May 24.

Department of Biological Engineering, MIT, Cambridge, MA 02139, USA; Department of Mechanical Engineering, MIT, Cambridge, MA 02139, USA; Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA 02139, USA. Electronic address:

Hyaline cartilages, fibrocartilages and elastic cartilages play multiple roles in the human body including bearing loads in articular joints and intervertebral discs, providing joint lubrication, forming the external ears and nose, supporting the trachea, and forming the long bones during development and growth. The structure and organization of cartilage's extracellular matrix (ECM) are the primary determinants of normal function. Most diseases involving cartilage lead to dramatic changes in the ECM which can govern disease progression (e. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Mar;32(5):372-374

Department of Otolaryngology Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, China.

To investigate the efficacy, recurrence and strategy of T silicone tube dilatation for cicatricial stenosis of cervical trachea in adults.Cinical data of 37 cases with the cervical tracheal stenosis were retrospectively analyzed, who were firstly treated by T shape silicone tube dilation for at least 10 months, from Jun 2006 to Jun 2016.In 37 adult patients with cicatricial stenosis of the trachea, 29 cases were caused by tracheal intubation or incision, 6 cases were traumatic, and 2 cases were multiple osteochondritis. Read More

Jpn J Ophthalmol 2018 Jul 23;62(4):517-524. Epub 2018 May 23.

Department of Ophthalmology, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Purpose: To investigate the clinical characteristics of Japanese patients with scleritis STUDY DESIGN: Retrospective study METHODS: The clinical records of 123 patients with scleritis, who presented to the University of Tokyo Hospital between January, 2004 and December, 2015, were retrospectively reviewed.

Results: The cohort comprised 55 men and 68 women (mean age, 57.8±16. Read More

BMC Nephrol 2018 May 23;19(1):120. Epub 2018 May 23.

Department of Nephrology and Endocrinology, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan.

Background: Podocyte phospholipase A receptor (PLAR) is a major target antigen in idiopathic adult membranous nephropathy (MN). Histological PLAR staining in the renal tissue has proven to be useful for the detection of idiopathic MN. However, glomerular PLAR deposits have also been recently observed in several patients with secondary MN, such as hepatitis B virus-associated, hepatitis C virus-associated, and neoplasm-associated MN. Read More

Int J Dermatol 2018 11 20;57(11):1363-1364. Epub 2018 May 20.

University of Tunis El Manar, Department of Dermatology, Charles Nicolle Hospital, Tunis, Tunisia.

Clin Exp Dermatol 2018 10 16;43(7):823-824. Epub 2018 May 16.

Experimental and Clinical Medicine Department, University of Florence, Florence, Italy.

Can Fam Physician 2018 May;64(5):363-367

Clinical Assistant Professor in the Department of Family Medicine at the University of Alberta.

Ann Rheum Dis 2018 May 3. Epub 2018 May 3.

Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University, Moscow, Russia.

N Engl J Med 2018 May;378(18):1715

University of Missouri, Columbia, MO.

Rheumatology (Oxford) 2018 10;57(10):1768

Institute for Autoimmune Systemic and Neurological Diseases, Athens, Greece.

Drug Metab Pers Ther 2018 Jun;33(2):105-108

Hacettepe University Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Ankara, Turkey.

Background: Relapsing polychondritis (RP) is a rare autoimmune disorder, and myelodysplastic syndrome (MDS) is accompanied by RP at variable rates. Herein, we report a case with RP and MDS who responded dramatically to 5-azacitidine for MDS.

Case Presentation: With conventional immunosuppressive treatment, our patient had several episodes of different side effects, including infections. Read More

BMC Neurol 2018 Apr 25;18(1):53. Epub 2018 Apr 25.

Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan, 430030, China.

Background: Relapsing polychondritis (RP) is an uncommon immune-related disease with unknown causes. It is characterized by inflammation of cartilaginous or non-cartilaginous structures, such as the ears, nose, respiratory tract, eyes, and joints. Neurological involvement is rare in RP. Read More

Mod Rheumatol 2018 Sep 22;28(5):766-769. Epub 2018 May 22.

a Laboratory for Statistical Analysis , RIKEN Center for Integrative Medical Sciences , Yokohama , Japan.

Rare autoimmune diseases are difficult to conduct researches in spite of present era with advanced scientific progress. Research using genetic approach is a promising way since genetic findings implicate causality of diseases. Still, there are multiple obstacles preventing genetic studies of rare diseases. Read More

Ann Rheum Dis 2018 Aug 13;77(8):1172-1178. Epub 2018 Mar 13.

UMR 1027, INSERM, University of Toulouse, Toulouse, France.

Objectives: To assess the efficacy and the safety of biologics in a cohort of patients with relapsing polychondritis (RP).

Methods: We conducted a French multicentre retrospective cohort study including patients treated with biologics for RP. Efficacy outcomes were clinical response (partial or complete) and complete response during the first 6 months of exposure, plus daily corticosteroid dose at 6 months. Read More

Turk Arch Otorhinolaryngol 2017 Jun 1;55(2):77-82. Epub 2017 Jun 1.

Clinic of Otorhinolaryngology, Gülhane Training and Research Hospital, Ankara, Turkey.

Relapsing polychondritis (RP) is a rare autoimmune and inflammatory disease, particularly characterized by recurrent inflammation of the hyaline cartilage. Laryngotracheal involvement in RP is the most serious complication that is observed in 50% of the patients and may lead to a life-threatening condition. The most common cause of death is laryngotracheal stenosis associated with lung infections or severe respiratory insufficiency that may be observed in 10%-50% of the patients. Read More

Open Access Rheumatol 2018 9;10:1-11. Epub 2018 Jan 9.

Department of Rheumatology, Henri Mondor Hospital, University Paris 12, Créteil, France.

Relapsing polychondritis is a severe systemic immune-mediated disease characterized by an episodic and progressive inflammatory condition with progressive destruction of cartilaginous structures. This disease has for nearly a century kept secrets not yet explained. The real incidence and prevalence of this rare disease are unknown. Read More

Medicine (Baltimore) 2017 Dec;96(51):e9378

Department of Rheumatology and Immunology, First Affiliated Hospital of Zhengzhou University, Zhengzhou City, Henan Province, P.R. China.

Ratioinale: Relapsing polychondritis (RP) is a rare and heterogeneous disease complex of unknown origin which basically affects cartilaginous structures, 40% of which accompanied by rheumatic, hematologic, and endocrine disease. Among them, vasculitis is the most common accompanying type and usually presented with positive antineutrophilic cytoplasmic antibody (ANCA). The presence of ANCA could be primary or drug-induced like propylthiouracil (PTU). Read More

J Clin Rheumatol 2018 Jan 31. Epub 2018 Jan 31.

J Clin Rheumatol 2018 Jan 30. Epub 2018 Jan 30.

A 55-year-old woman with relapsing polychondritis had progressively enlarged right retro-orbital tumor invading the optic nerve, followed by left retrobulbar infiltrating lesions despite prescription of high-dose corticosteroids and pulse methylprednisolone. Repeated histopathologic analyses showed dense collagen fibers with scanty inflammatory cells, consistent with the diagnosis of idiopathic sclerosing orbital inflammation. This disorder has been recognized as a distinct entity with unique clinical features and coexisting rheumatologic disorders, requiring more focused diagnostic strategies and therapeutic regimens. Read More

J Bras Pneumol 2017 Jul-Aug;43(4):251

. Universidade Federal do Rio de Janeiro, Rio de Janeiro (RJ) Brasil.

Ann Am Thorac Soc 2018 Mar;15(3):290-292

Silver Spring, Maryland.

J Clin Rheumatol 2017 Dec 27. Epub 2017 Dec 27.

We describe a 69-year-old man who presented with a right sternocleidomastoid intramuscular abscess that grew Propionibacterium acnes. Despite initial improvement with antibiotics, he subsequently developed signs and symptoms fulfilling diagnostic criteria for hemophagocytic lymphohistiocytosis (HLH)-fevers, cytopenias, hyperferritinemia, splenomegaly, and low natural killer cell activity. The patient improved spontaneously but at outpatient follow-up complained of erythema over the bridge of his nose as well as bilateral ear redness sparing the earlobes at which point relapsing polychondritis (RP) was diagnosed. Read More

J Thorac Dis 2017 Nov;9(11):E1002-E1004

Division of Thoracic Surgery, Toronto General Hospital, University of Toronto, Toronto, Canada.

Tracheobronchial malacia occurs in 50% of patients with relapsing polychondritis (RP), and is often managed with stent insertion. While severe complications have been described after silicone tracheal stent insertion, there are few reports describing tracheal injury in patients with RP. We present a case of tracheal perforation secondary to Dumon stent manipulation in a patient with RP. Read More