6,995 results match your criteria Polyarteritis Nodosa


Management of Cutaneous Vasculitis.

Presse Med 2020 Jul 6:104033. Epub 2020 Jul 6.

Vasculitis Clinic, Division of Rheumatology, Mount Sinai Hospital, University of Toronto, 60 Murray Street, Ste 2-220, M5T 3L9 Toronto, ON, Canada. Electronic address:

Cutaneous vasculitis encompasses cutaneous components of systemic vasculitides, skin-limited variants of systemic vasculitides, such as IgA vasculitis or cutaneous polyarteritis nodosa, and single-organ cutaneous vasculitis, as individualized in 2012 in the Chapel Hill Consensus Conference Nomenclature. In this article, we focus on the management of skin-limited and single-organ vasculitides, often referred to, in clinical practice, as isolated "cutaneous leukocyctoclastic vasculitis", terms which may correspond to histological findings or descriptions, but are imprecise and not specific. Since most cases of isolated cutaneous vasculitis are self-limited and resolve spontaneously over 3 to 4 weeks, most patients require no systemic treatment. Read More

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http://dx.doi.org/10.1016/j.lpm.2020.104033DOI Listing

Putting the Pieces Into Place: A Case of Systemic Polyarteritis Nodosa.

Cureus 2020 Jun 4;12(6):e8442. Epub 2020 Jun 4.

Dermatology, University of Rochester Medical Center, Rochester, USA.

This is a case of systemic polyarteritis nodosa (PAN) in a 43-year-old male who initially presented to the hospital with a puzzling collection of signs and symptoms, including fever, arthralgias, myalgias, abdominal pain, dark urine, and rash. His illness evolved over the course of four weeks, and skin biopsy helped to clinch the diagnosis and lead to appropriate treatment. It is important to consider systemic PAN in the work-up of patients with subtle skin findings in the context of seemingly unrelated constitutional, abdominal, genitourinary, cardiac, and neurological signs and symptoms. Read More

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http://dx.doi.org/10.7759/cureus.8442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336694PMC

Anti-Phosphatidylserine/Prothrombin antibodies in patients with Polyarteritis Nodosa.

Reumatol Clin 2020 Jul 1. Epub 2020 Jul 1.

Departamento de Inmunología y Reumatología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México. Electronic address:

Introduction: Anti-phosphatidylserine/prothrombin (aPS/PT) antibodies have been described in cutaneous Polyarteritis Nodosa (PAN) in association with specific manifestations.

Objectives: To determine aPS/PT antibodies in patients with PAN and its correlation with clinical manifestations.

Methods: Cross-sectional comparative study including PAN patients and 20 controls (10 Microscopic Polyangiitis [MPA] and 10 Behçet's disease [BD]). Read More

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http://dx.doi.org/10.1016/j.reuma.2020.05.010DOI Listing

Bilateral subcutaneous pyelovesical bypass in a Hautmann neobladder followed by a mononeuropathy multiplex and an underlying polyarteritis nodosa diagnosis.

Arch Ital Urol Androl 2020 Jun 23;92(2). Epub 2020 Jun 23.

Neurology Department, Henry Dunant Hospital Center, Athens.

Subcutaneous pyelovesical bypasses are the best choice for the long-term palliative treatment of ureteral obstructions. In rare cases this obstruction is due to polyarteritis nodosa. We present the only reported patient with a bilateral Detour bypass in a Hautmann's neobladder. Read More

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http://dx.doi.org/10.4081/aiua.2020.2.119DOI Listing

The ratio of CD163-positive macrophages to Iba1-positive macrophages is low in the intima in the early stage of cutaneous arteritis.

Immunol Res 2020 Jun;68(3):152-160

Department of Pathology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, 390-8621, Japan.

The etiology of polyarteritis nodosa (PAN) and localized PAN, including cutaneous arteritis (CA), remains unknown; however, initial endothelial damage has been implicated. The intima of the vasculitis lesions is predominantly infiltrated by innate-like bystander-activated CD8 T cells, in addition to the macrophages. Macrophages are among the major inflammatory cells involved in innate immunity and are classified into M1 and M2 subtypes. Read More

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http://dx.doi.org/10.1007/s12026-020-09140-wDOI Listing

Two cases of ADA2 deficiency presenting as childhood polyarteritis nodosa: novel ADA2 variant, atypical CNS manifestations, and literature review.

Clin Rheumatol 2020 Jun 13. Epub 2020 Jun 13.

Young Adult and Pediatric Rheumatology Unit, Centro Hospitalar e Universitário do Hospital de São João, Porto, Portugal.

Deficiency of adenosine deaminase 2 (DADA2) is an autosomal recessive disease resulting from loss-of-function pathogenic variants in ADA2 gene, which might resemble polyarteritis nodosa (PAN). The authors present two pediatric cases of ADA2 deficiency with phenotypic manifestations of PAN, including an unusual presentation with spinal cord ischemia. Also described is an assessment of ADA2 activity and gene expression profiling with description of a previously unreported homozygous variant, c. Read More

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http://dx.doi.org/10.1007/s10067-020-05210-4DOI Listing

Periodic fever syndromes: a patient diagnosed with recurrent Kawasaki disease.

Cardiol Young 2020 Jun 11:1-3. Epub 2020 Jun 11.

Department of Pediatric Immunology, Faculty of Medicine, Ege University, Izmir, Turkey.

Kawasaki disease, known as mucocutaneous lymph node syndrome, is a multi-system disease of unknown aetiology that occurs in young children under 5 years of age. The recurrence rate of Kawasaki disease is as rare as 1-3%. Especially in cases with coronary artery involvement, recurrent Kawasaki disease should be investigated in terms of underlying rheumatologic diseases such as periodic fever syndromes, microscopic polyangiitis, polyarteritis nodosa, and systemic-onset juvenile arthritis. Read More

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http://dx.doi.org/10.1017/S1047951120001444DOI Listing

Polyarteritis nodosa with genital necrosis.

Urol Case Rep 2020 Nov 28;33:101285. Epub 2020 May 28.

Chairman of Urology, Clínica San Camilo, Buenos Aires, Argentina.

Polyarteritis nodosa (PAN) is a multisystemic disease that is characterized by the presence of necrotizing vasculitis of small and medium-sized blood vessels. Genital compromise is rare. Our patient presented a systemic disease associated to genital signs (penis and scrotum skin necrosis). Read More

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http://dx.doi.org/10.1016/j.eucr.2020.101285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270192PMC
November 2020

Successful treatment of tumor necrosis factor inhibitor-resistant cutaneous polyarteritis nodosa with tocilizumab.

Pediatr Int 2020 Jun 8;62(6):753-755. Epub 2020 Jun 8.

Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.

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http://dx.doi.org/10.1111/ped.14184DOI Listing

Successful treatment of painful chronic wounds with amniotic and umbilical cord tissue: A case series.

Authors:
Pablo Acevedo

SAGE Open Med Case Rep 2020 27;8:2050313X20910599. Epub 2020 Apr 27.

Florida Hospital North Pinellas Wound Healing Institute of Trinity, New Port Richey, FL, USA.

Patients with chronic wounds may experience persistent, debilitating pain that cannot be adequately managed with analgesics and that negatively impacts their quality of life. In this case series, three painful chronic and ischemic wounds that were caused by polyarteritis nodosa vasculitis ( = 1) and peripheral arterial disease (PAD) ( = 2) were successfully treated with cryopreserved umbilical cord tissue and/or amniotic membrane and umbilical cord particulate, resulting in notable reduction in pain within 7 days followed by expedited wound closure. No adverse events related to these tissue products were observed. Read More

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http://dx.doi.org/10.1177/2050313X20910599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233887PMC

Radiologic Imaging in Large and Medium Vessel Vasculitis.

Radiol Clin North Am 2020 Jul;58(4):765-779

Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Martinistraße 52, Hamburg 20251, Germany.

Vasculitides are a complex group of diseases sharing the defining feature of inflamed vessel walls. Vasculitides can be classified depending on the size of the predominantly affected vessels. Modern cross-sectional imaging methods have become a cornerstone in the diagnosis of vasculitis and may help in narrowing down differential diagnoses. Read More

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http://dx.doi.org/10.1016/j.rcl.2020.02.001DOI Listing

Clusters in Pediatric Rheumatic Diseases.

Curr Rheumatol Rep 2020 May 20;22(7):28. Epub 2020 May 20.

Division of Pediatric Rheumatology, Department of Pediatrics, Hacettepe University Faculty of Medicine, 06100, Ankara, Turkey.

Purpose Of The Review: Rheumatic diseases usually have very diverse and complex pathophysiology resulting in different clinical phenotypes. Some certain phenotypes cluster together with a common presentation, course, and outcome. Our primary aim is to review the known disease clusters in certain rheumatological conditions. Read More

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http://dx.doi.org/10.1007/s11926-020-00908-5DOI Listing
May 2020
2.454 Impact Factor

[Cutaneous vasculitis and vasculopathy : Differential diagnosis in biopsies of the lower extremities].

Pathologe 2020 Jul;41(4):355-363

, Dermatopathologie Lübeck, Deutschland.

The skin is one of the most frequently involved organs in primary systemic and secondary vasculitis; moreover, a vasculitis can occur as single organ vasculitis, limited to the skin. For most types of vasculitis, the lower extremities constitute common sites with clinical symptoms of palpable purpura, nodules, and ulcers. In histopathology of cutaneous vasculitis, it is of utmost importance to correctly identify the vessel types involved and to discriminate between vasculitic vessel damage, unspecific reactive vessel changes, vascular occlusive diseases, noninflammatory purpura, or perivascular infiltrates due to other inflammatory skin diseases. Read More

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http://dx.doi.org/10.1007/s00292-020-00786-9DOI Listing

Reuma.pt/vasculitis - the Portuguese vasculitis registry.

Orphanet J Rare Dis 2020 May 5;15(1):110. Epub 2020 May 5.

Rheumatology Department, Hospital de Santa Maria - Centro Hospitalar Universitário Lisboa Norte, Centro Académico de Medicina de Lisboa, Lisbon, Portugal.

Background: The vasculitides are a group of rare diseases with different manifestations and outcomes. New therapeutic options have led to the need for long-term registries. The Rheumatic Diseases Portuguese Register, Reuma. Read More

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http://dx.doi.org/10.1186/s13023-020-01381-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201571PMC

Systemic Lupus Erythematosus Associated With Polyarteritis Nodosa-Like Muscular Vasculitis.

J Clin Rheumatol 2020 Apr 25. Epub 2020 Apr 25.

From the Service de Médicine Interne, Centre de Référence des Maladies Auto-Immunes et Systémiques Rares d'ile de France, Hôpital Cochin, APHP.

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http://dx.doi.org/10.1097/RHU.0000000000001397DOI Listing

Protocol for a randomized multicenter study for isolated skin vasculitis (ARAMIS) comparing the efficacy of three drugs: azathioprine, colchicine, and dapsone.

Trials 2020 Apr 28;21(1):362. Epub 2020 Apr 28.

Divison of Rheumatology and Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, USA.

Background: Skin-limited forms of vasculitis, while lacking systemic manifestations, can persist or recur indefinitely, cause pain, itch, or ulceration, and be complicated by infection or scarring. High-quality evidence on how to treat these conditions is lacking. The aim of this comparative effectiveness study is to determine the optimal management of patients with chronic skin-limited vasculitis. Read More

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http://dx.doi.org/10.1186/s13063-020-04285-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189702PMC

Cutaneous arteriolitis: A novel cutaneous small vessel vasculitis disorder clinicopathologically different from cutaneous polyarteritis nodosa and cutaneous venulitis.

J Cutan Pathol 2020 Apr 27. Epub 2020 Apr 27.

Meguro Chen Dermatology Clinic, Tokyo, Japan.

Cutaneous vasculitis can be classified into two types based on the affected vessel size: small vessel vasculitis predominantly affecting dermal venules, and muscular vessel vasculitis as found in cutaneous arteritis predominantly affecting arteries located at the dermal-subcutaneous junction. We describe two cases with a novel small vessel vasculitis disorder, which exclusively affected arterioles in the mid-dermis, and demonstrate clinical and pathological difference distinct from cutaneous polyarteritis nodosa and cutaneous venulitis. Both patients were male, and presented with painful infiltrative plaques, involving the palms, soles, and thighs without extracutaneous involvement except for fever and arthralgia. Read More

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http://dx.doi.org/10.1111/cup.13726DOI Listing

Polyarteritis nodosa and deficiency of adenosine deaminase 2 - Shared genealogy, generations apart.

Clin Immunol 2020 Jun 7;215:108411. Epub 2020 Apr 7.

Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Division of Immunology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA. Electronic address:

Polyarteritis nodosa (PAN) is a systemic necrotizing vasculitis that predominantly affects medium-sized arteries. With the establishment and refinement of vasculitis nomenclature and diagnostic criteria, clinical findings of PAN and distinguishing features from other vasculitides are now well characterized. Although PAN typically manifests in adulthood, cohort studies in paediatric patients have shaped our understanding of childhood-onset PAN. Read More

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http://dx.doi.org/10.1016/j.clim.2020.108411DOI Listing

Alpha-1 Antitrypsin Deficiency in an Infant With Polyarteritis Nodosa.

J Clin Rheumatol 2020 Apr 1. Epub 2020 Apr 1.

Department of Pediatrics University of Alabama at Birmingham Birmingham, AL Division of Pediatric Rheumatology Department of Pediatrics University of Alabama at Birmingham Birmingham, AL Department of Pathology and Laboratory Medicine University of Alabama at Birmingham Birmingham, AL Division of Pediatric Gastroenterology Hepatology and Nutrition Department of Pediatrics University of Alabama at Birmingham Birmingham, AL.

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http://dx.doi.org/10.1097/RHU.0000000000001266DOI Listing

Choroidal vascularity index as a biomarker of systemic inflammation in childhood Polyarteritis Nodosa and adenosine deaminase-2 deficiency.

Pediatr Rheumatol Online J 2020 Apr 3;18(1):29. Epub 2020 Apr 3.

Department of Ophthalmology, Hacettepe University School of Medicine, Ankara, Turkey.

Background/purpose: To assess EDI-OCT (enhanced depth imaging optical coherence tomography) of choroid for inflammatory signs in children with polyarteritis nodosa (PAN) and adenosine deaminase-2 deficiency (DADA-2).

Methods: In this cross-sectional study conducted between June 2017 and September 2018, we evaluated children diagnosed with PAN (n = 11) and DADA-2 (n = 4) and an age- and sex-matched control group (n = 15). Demographic and laboratory data were retrospectively analyzed from patient charts. Read More

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http://dx.doi.org/10.1186/s12969-020-0417-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118843PMC

Mastitis in Autoimmune Diseases: Review of the Literature, Diagnostic Pathway, and Pathophysiological Key Players.

J Clin Med 2020 Mar 30;9(4). Epub 2020 Mar 30.

St Eloi Hospital, Department of Internal Medicine and Multi-Organic Diseases, Local Referral Center for Systemic and Autoimmune Diseases, 80 Avenue Augustin Fliche, F-34295 Montpellier, France.

Mastitis frequently affects women of childbearing age. Of all the pathological breast conditions requiring specific management, autoimmune mastitis is in the third position after infection and breast cancer. The aim of this literature review was to make a comprehensive description of autoimmune diseases targeting the mammary gland. Read More

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http://dx.doi.org/10.3390/jcm9040958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231219PMC

Is Infection Another Possible Trigger for Polyarteritis Nodosa?

Eur J Case Rep Intern Med 2020 18;7(3):001403. Epub 2020 Feb 18.

Department of Internal Medicine 1, Centro Hospitalar de Leiria, Leiria, Portugal.

Polyarteritis nodosa is a systemic necrotizing vasculitis that typically affects medium-sized muscular arteries, with occasional involvement of small muscular arteries. Most cases of polyarteritis nodosa are idiopathic but multiple infectious agents have been associated with this disease. We present a clinical case of a 72-year-old male with fever, diarrhoea and haemodynamic instability, diagnosed with a bacterial infection caused by Typhi. Read More

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http://dx.doi.org/10.12890/2020_001403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083181PMC
February 2020

Tocilizumab treatment for polyarteritis nodosa.

Rheumatology (Oxford) 2020 Mar 17. Epub 2020 Mar 17.

Department of Rheumatology, Clinical Immunology and Nephrology, Asklepios Klinik Altona, Hamburg, Klinikum Bad Bramstedt, Germany.

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http://dx.doi.org/10.1093/rheumatology/keaa079DOI Listing

Bilateral interstitial keratitis, erythema nodosum and atrial fibrillation as presenting signs of polyarteritis nodosa.

Am J Ophthalmol Case Rep 2020 Jun 21;18:100619. Epub 2020 Feb 21.

Athens Vision Eye Institute, Athens, Greece.

Purpose: To report a case of Polyarteritis Nodosa (PAN) presenting as bilateral episcleritis and interstitial keratitis along with erythema nodosum and atrial fibrillation and to review the ophthalmic literature on PAN with anterior segment findings.

Observations: A 35-year old man presented with a two-month history of bilateral episcleritis, skin lesions consistent with erythema nodosum, joint effusions and episodes of prolonged diarrhea and atrial fibrillation. Ophthalmic examination was significant for bilateral diffuse episcleral injection and nummular corneal stromal infiltrates. Read More

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http://dx.doi.org/10.1016/j.ajoc.2020.100619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044707PMC

Polyarteritis Nodosa: an unusual case of paraneoplastic process in renal cell carcinoma.

J Community Hosp Intern Med Perspect 2020 10;10(1):73-75. Epub 2020 Feb 10.

University of Illinois College of medicine Peoria, Peoria, IL, USA.

Polyarteritis Nodosa (PAN) is a small and medium vessel necrotizing vasculitis that can affect any system in the human body. Rarely, PAN can be the primary manifestation of an underlying malignancy. The association between malignancy and vasculitis is an ongoing topic of research. Read More

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http://dx.doi.org/10.1080/20009666.2019.1703374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034481PMC
February 2020

Provisional seven-item criteria for the diagnosis of polyarteritis nodosa.

Rheumatol Int 2020 Aug 27;40(8):1223-1227. Epub 2020 Feb 27.

Department of Rheumatology, Hiroshima City Hiroshima Citizens Hospital, 7-33 Motomachi, Naka-ku, Hiroshima City, Hiroshima, 730-8518, Japan.

Polyarteritis nodosa (PAN) is a potentially life-threatening systemic vasculitis, which predominantly involves medium arteries. However, it may be difficult to diagnose PAN in its early stage. The aim of our study was to investigate the sensitivity and specificity of the American College of Rheumatology (ACR) and the Japanese Ministry of Health, Labour and Welfare (MHLW) criteria for the diagnosis of PAN in a single-centre retrospective cohort in Japan and to develop simplified criteria with favourable diagnostic performance. Read More

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http://dx.doi.org/10.1007/s00296-020-04535-2DOI Listing

Survey of Japanese dermatological vasculitis specialists on cases of cutaneous arteritis (cutaneous polyarteritis nodosa).

J Dermatol 2020 May 24;47(5):534-537. Epub 2020 Feb 24.

Department of Dermatology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.

We developed a questionnaire to examine the findings of cutaneous arteritis among dermatological specialists experienced in vasculitis as certified by the Committee for guidelines for the management of vasculitis and vascular disorders of the Japanese Dermatological Association. We sent a questionnaire to 12 dermatological facilities identified through the revised Committee for guidelines for the management of vasculitis and vascular disorders of the Japanese Dermatological Association. Retrospective data obtained from 84 patients at the 12 dermatological facilities between 2012 January 2016 December were evaluated. Read More

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http://dx.doi.org/10.1111/1346-8138.15273DOI Listing

The "Nodes" in Polyarteritis Nodosa-Coronary Artery Aneurysms.

J Clin Rheumatol 2020 Mar;26(2):e32

Saint Luke's Cardiovascular Consultants, Kansas City, Missouri.

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http://dx.doi.org/10.1097/RHU.0000000000000806DOI Listing

Epidemiologic Features of Systemic Vasculitides in the Southeast Region of Brazil: Hospital-Based Survey.

J Clin Rheumatol 2019 Apr 23. Epub 2019 Apr 23.

UERJ (Licensed), Global Medical Expert, Immunology and Specialty Pharma, GSK, Collegeville, PA.

Background/objective: The epidemiology of vasculitis is variable in different geographic areas, and this issue has not been approached in Brazil yet. The objective of this study was to assess the frequency of vasculitis in specialized centers in Brazil.

Methods: This cross-sectional study was performed in 9 vasculitis outpatient clinics from 6 different states mainly from the Southeast and the Northeast regions of Brazil between 2015 and 2017. Read More

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http://dx.doi.org/10.1097/RHU.0000000000001041DOI Listing

Lymphocytic thrombophilic arteritis and cutaneous polyarteritis nodosa: Clinicopathologic comparison with blinded histologic assessment.

J Am Acad Dermatol 2020 Feb 7. Epub 2020 Feb 7.

Departments of Anatomical Pathology, St Vincent's Hospital Melbourne, Melbourne, Australia.

Background: Lymphocytic thrombophilic arteritis (LTA), or macular lymphocytic arteritis, is defined by a primary lymphocytic vasculitis. However, the nosology of LTA has been controversial, with speculation that it may represent an indolent non-nodule-forming variant of cutaneous polyarteritis nodosa (cPAN).

Objective: This study compares the clinicopathologic features of patients with LTA or cPAN to assess if these conditions should be considered distinct entities. Read More

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http://dx.doi.org/10.1016/j.jaad.2019.10.068DOI Listing
February 2020

Evaluating FMX-101 as a promising therapeutic for the treatment of acne.

Expert Opin Pharmacother 2020 May 8;21(7):741-746. Epub 2020 Feb 8.

Private Dermatology Practice, Hospital ABC Campus Santa Fe , Mexico city, Mexico.

Introduction: Oral minocycline is a mainstay of therapy for moderate-to-severe acne; however, systemic side effects which include hepatotoxicity, lupus-like syndrome, drug hypersensitivity syndrome, autoimmune hepatitis, polyarteritis nodosa, gastrointestinal side effects and skin hyperpigmentation are of concern. Topical antibiotics commonly used in acne, such as erythromycin and clindamycin, present high P. acnes resistance rates which has opened the market for new topical antibiotics. Read More

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http://dx.doi.org/10.1080/14656566.2020.1721461DOI Listing

An Atypical Case of Vasculitis: When 'Occult' 18FDG-PET Scan Findings Create a Classification Dilemma.

Eur J Case Rep Intern Med 2020 23;7(1):001301. Epub 2019 Dec 23.

Internal Medicine Department, Epicura Hospital, Baudour, Belgium.

We describe a 66-year old patient with a recurrent ulcer on her right ankle. Biopsy revealed medium-vessel vasculitis consistent with cutaneous polyarteritis nodosa. There were no signs or symptoms suggestive of systemic vasculitis, but a 18FDG-PET scan showed areas of increased uptake around the large arteries and the pelvic and shoulder girdles. Read More

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http://dx.doi.org/10.12890/2019_001301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6993910PMC
December 2019

Hypertensive Crisis: The Other Side of Polyarteritis Nodosa.

Cureus 2020 Jan 26;12(1):e6775. Epub 2020 Jan 26.

Pediatric Intensive Care Unit, King Khalid University Hospital, Riyadh, SAU.

Hypertensive crisis is a deadly complication that should be avoided at all costs, let alone when it is associated with a rare disease, such as polyarteritis nodosa. We present a case of a child who initially came to our hospital with a prolonged high-grade fever responding to antipyretics. Upon follow up, the patient went into a hypertensive crisis, which led to the admission to the Pediatric Intensive Care Unit (PICU). Read More

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http://dx.doi.org/10.7759/cureus.6775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984167PMC
January 2020

Livedo Racemosa: Clinical, Laboratory, and Histopathological Findings in 33 Patients.

Int J Low Extrem Wounds 2020 Jan 29:1534734619896938. Epub 2020 Jan 29.

Federal University of Bahia, Hospital Universitario Prof. Edgard Santos, Salvador BA, Brazil.

Livedo racemosa is a cutaneous finding characterized by a persistent, erythematous, or violaceous discoloration of the skin, in a broken, branched, discontinuous, and irregular pattern. A retrospective review of 33 cases with clinical diagnosis of livedo racemosa over the past 6 years was evaluated in the dermatology department of a tertiary care hospital. We found predominance in Caucasian women (78. Read More

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http://dx.doi.org/10.1177/1534734619896938DOI Listing
January 2020
1.194 Impact Factor

Polyarteritis nodosa isolated to muscles-A case series with a review of the literature.

Semin Arthritis Rheum 2020 06 28;50(3):503-508. Epub 2019 Dec 28.

Department of Clinical Immunology, PathWest Laboratory Medicine WA, Queen Elizabeth II Medical Centre, Perth, Western Australia, Australia; Department of Clinical Immunology, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia.

Muscular polyarteritis nodosa where disease is isolated to skeletal muscle is a rare and often poorly recognised clinical entity. Patients typically present with fever and severe muscle pain limiting ability to ambulate without rise in creatine kinase. Often there is a significant delay between presentation and diagnosis, which requires histological confirmation. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2019.12.002DOI Listing

Endovascular Treatment of Distal Lenticulostriate Artery Aneurysm by Selective Catheterization of Artery with Balloon-Blocking Technique: 2-Dimensional Video Illustration.

World Neurosurg 2020 Apr 16;136:220. Epub 2020 Jan 16.

Department of Neurosciences, Medanta the Medicity, Gurgaon, Haryana, India. Electronic address:

We report the case of a 15-year-old male patient with polyarteritis nodosa who presented with ruptured lenticulostriate artery (LSA) aneurysm and was successfully treated with endovascular N-butyl-2-cyanoacrylate (Histoacryl, B. Braun, Melsungen, Germany) acrylic glue embolization. Selective catheterization of LSA is sometimes difficult even with a low-profile microcatheter (Magic 1. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.01.054DOI Listing
April 2020
2.417 Impact Factor

Atypical phenotype of an old disease or typical phenotype of a new disease: deficiency of adenosine deaminase 2.

Turk J Pediatr 2019 ;61(3):413-417

Division of Immunology, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, USA.

Çakan M, Aktay-Ayaz N, Karadağ ŞG, Tahir-Turanlı E, Stafstrom K, Bainter W, Geha RS, Chou J. Atypical phenotype of an old disease or typical phenotype of a new disease: deficiency of adenosine deaminase 2. Turk J Pediatr 2019; 61: 413-417. Read More

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http://dx.doi.org/10.24953/turkjped.2019.03.014DOI Listing
January 2019

The color of skin: purple diseases of the skin, nails, and mucosa.

Clin Dermatol 2019 Sep - Oct;37(5):528-547. Epub 2019 Jul 17.

The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York, USA. Electronic address:

The color purple can be seen in several types of eruptions including inflammatory dermatoses like lichen planus, infectious dermatoses like ecthyma gangrenosum, neoplasms like Kaposi sarcoma, and vasculitis and vasculopathy. The current review focuses on the clinical appearance, pathophysiology, and treatment of several vasculitides and vasculopathies including capillaritis, cutaneous small-vessel vasculitis, immunoglobulin A (IgA) vasculitis, cryoglobulinemia, granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis, microscopic polyangiitis, polyarteritis nodosum, warfarin-induced skin necrosis, heparin-induced thrombocytopenia, purpura fulminans, antiphospholipid antibody syndrome, calciphylaxis, levamisole-induced vasculopathy, and thrombotic thrombocytopenic purpura. Dermatologists play a central role in treating patients with cutaneous vasculitis and vasculopathy and may have the opportunity to facilitate identification of systemic disease by diagnosing cutaneous vasculitis and vasculopathy. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2019.07.016DOI Listing

Is macular lymphocytic arteritis limited to the skin? Long-term follow-up of seven patients.

An Bras Dermatol 2020 Jan - Feb;95(1):32-39. Epub 2019 Nov 22.

Department of Dermatology, Hospital das Clinicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil; Faculdade de Medicina do ABC, Santo André, SP, Brazil.

Background: Macular lymphocytic arteritis most commonly presents as hyperpigmented macules on the lower limbs. The pathogenesis of this disease is still unclear and there is an ongoing debate regarding whether it represents a new form of cutaneous vasculitis or an indolent form of cutaneous polyarteritis nodosa.

Objective: To describe clinical, histopathological, and laboratory findings of patients with the diagnosis of macular lymphocytic arteritis. Read More

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http://dx.doi.org/10.1016/j.abd.2019.05.001DOI Listing
March 2020
0.866 Impact Factor

Cutaneous polyarteritis nodosa in a 7-year-old boy: difficulties in diagnosis.

Reumatologia 2019 31;57(5):301-305. Epub 2019 Oct 31.

Department of Pediatrics, Faculty of Medicine and Health Sciences, Andrzej Frycz Modrzewski Krakow University, Poland.

Vasculitides are a diverse group of diseases. The potential diversity of their clinical symptoms requires the exclusion of other systemic connective tissue diseases, infectious diseases or malignancies. Due to similar clinical manifestations, comprehensive differential diagnosis is needed. Read More

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http://dx.doi.org/10.5114/reum.2019.89525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911246PMC
October 2019

Measuring Vasculitis with Numbers: Outcome Scores.

Curr Rheumatol Rev 2020 ;16(1):21-28

Division of Rheumatology, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.

Primary Systemic Vasculitides (PSV) are a heterogeneous group of diseases. Outcome scores are important to evaluate vasculitis patients in a more structured and standard way and these help physicians to predict patients with poor prognosis or high risk of relapse. Furthermore, we need reliable outcome measures for clinical trials. Read More

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http://dx.doi.org/10.2174/1573397115666191126093927DOI Listing
January 2020

Cutaneous manifestations of HAV, HBV, HCV.

G Ital Dermatol Venereol 2019 Dec 4. Epub 2019 Dec 4.

DISSAL, Department of Dermatology, Ospedale Policlinico San Martino, Genoa, Italy.

Hepatotropic viral infections are a relevant global health problem and present multiple extrahepatic manifestations in addition to hepatic disease. Along with generic cutaneous symptoms correlated to the cholestatic liver disease that may arise during the infection, some cutaneous manifestations of hepatotropic viral infections are characteristic, enabling to suspect the underlying infection. This review will present the principal cutaneous manifestations of hepatotropic virus infection. Read More

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http://dx.doi.org/10.23736/S0392-0488.19.06488-5DOI Listing
December 2019

Acute sensorimotor polyneuropathy as an early sign of polyarteritis nodosa. A case report.

Acta Myol 2019 Sep 1;38(3):184-188. Epub 2019 Sep 1.

Department of Neurology, First Pavlov State Medical University, St. Petersburg, Russia.

We examined a patient aged 31 who had a sudden burning paraesthesia, pain and numbness in the lower legs together with an increased temperature of 39°C. Clinical examination showed asymmetrical sensory polyneuropathy more clearly seen in the lower legs and the left wrist, with high ESR (up to 44 mm/h), leukocytosis, slight anemia and proteinuria. CSF was normal. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859414PMC
September 2019

Successful treatments of polyarteritis nodosa cerebral vasculitis and recurrent septicaemia in a dialysis patient.

BMJ Case Rep 2019 Nov 28;12(11). Epub 2019 Nov 28.

Renal Medicine, Treetop Hospital, Hulhumale, Maldives.

We report a case of cerebral vasculitis in a 31-year-old woman who presented with chronic kidney disease stage 5, labile hypertension and severe headaches. The diagnosis of cerebral vasculitis made on magnetic resonance angiography (MRA) and late diagnosis of polyarteritis nodosa were made by conventional CT angiography. Immunosuppression was complicated by recurrent septicaemia due to Treatment of the vasculitis resulted in marked improvement of MRA appearances, headaches and anxiety and stabilisation of blood pressure. Read More

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http://dx.doi.org/10.1136/bcr-2019-231478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6887464PMC
November 2019

Skin Picking Disorder in a Woman with Polyarteritis Nodosa. Case Report.

Rev Colomb Psiquiatr 2019 Oct - Dec;48(4):261-265. Epub 2018 May 7.

Pontificia Universidad Javeriana, Bogotá, Colombia; Hospital Universitario San Ignacio, Bogotá, Colombia. Electronic address:

Introduction: Excoriation (skin picking) disorder is included in the DSM-5 in the obsessive compulsive and related disorders category. It is defined as the recurrent urge to touch, scratch, scrape, scrub, rub, squeeze, bite or dig in the skin, leading to skin lesions. It is a rare disorder (1. Read More

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http://dx.doi.org/10.1016/j.rcp.2018.03.001DOI Listing

A large superior mesenteric artery aneurysm and ileal obstruction: a rare presentation of polyarteritis nodosa in an infant.

Oxf Med Case Reports 2019 Sep 28;2019(9):omz092. Epub 2019 Sep 28.

Department of Allergy, Infectious Diseases and Immunology, Gunma Children's Medical Center, Shibukawa 377-8577, Japan.

Polyarteritis nodosa (PAN) is a rare form of vasculitis that occurs in childhood and affects small- and medium-sized arteries. Large aneurysms due to PAN can induce fatal complications like rupturing or occlusion of the affected arteries. Here, we report a case of a 4-month-old girl with PAN complicated by a large superior mesenteric artery aneurysm and ileal obstruction. Read More

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http://dx.doi.org/10.1093/omcr/omz092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765372PMC
September 2019

Concurrence of polyarteritis nodosa and multiple sclerosis.

J Eur Acad Dermatol Venereol 2020 Apr 9;34(4):e188-e191. Epub 2020 Feb 9.

Department of Dermatology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1111/jdv.16107DOI Listing

Disseminated Tuberculosis and Saccular Aneurysm Findings on FDG PET/CT in a Patient With Polyarteritis Nodosa.

J Clin Rheumatol 2019 Nov 22. Epub 2019 Nov 22.

From the Department of Nuclear Medicine, Izmir Dr. Suat Seren Chest Diseases and Surgery Training and Research Hospital, University of Health Sciences, Izmir, Turkey.

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http://dx.doi.org/10.1097/RHU.0000000000001239DOI Listing
November 2019

A funny case of Funiculitis.

Acta Clin Belg 2019 Nov 23:1-4. Epub 2019 Nov 23.

Department of Nephrology, AZ Groeninge, Kortrijk, Belgium.

: Funiculitis, an inflammation of the spermatic cord, usually results from infection of adjacent structures like the epididymis, testis or the urethra. It is most frequently caused by a bacterial infection, but has a broad (non-infectious) differential diagnosis.: This case illustrates an unusual cause of funiculitis. Read More

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http://dx.doi.org/10.1080/17843286.2019.1696029DOI Listing
November 2019

Rheumatoid Vasculitis: Is It Always a Late Manifestation of Rheumatoid Arthritis?

Cureus 2019 Sep 28;11(9):e5790. Epub 2019 Sep 28.

Internal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, USA.

Rheumatoid vasculitis (RV) is an infrequent complication of longstanding severe rheumatoid arthritis (RA). The active vasculitis associated with rheumatoid disease occurs in about 1%-5% of the patient population. RV is a manifestation of "extra-articular" rheumatoid arthritis and involves the small- and medium-sized arteries in the body. Read More

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http://dx.doi.org/10.7759/cureus.5790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827848PMC
September 2019