756 results match your criteria Polimery w medycynie[Journal]


The polymorphism of statins and its effect on their physicochemical properties.

Polim Med 2018 Jul-Dec;48(2):77-82

Department of Physical Pharmacy and Pharmacokinetics, Poznan University of Medical Sciences, Poland.

Polymorphism of pharmaceutical substances has a significant impact on their physicochemical properties, durability, bioavailability and consequently on their pharmacological activity. Solid dosage forms may exist in both crystalline and amorphous forms. Amorphous varieties are characterized by higher solubility and dissolution rates, while crystalline forms show greater purity and storage stability. Read More

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http://dx.doi.org/10.17219/pim/102978DOI Listing
April 2019
1 Read

The preparation and physicochemical characterization of eprosartan mesylate-laden polymeric ternary solid dispersions for enhanced solubility and dissolution rate of the drug.

Polim Med 2018 Jul-Dec;48(2):69-75

Faculty of Pharmacy, University of Central Punjab, Lahore, Pakistan.

Background: Eprosartan mesylate is a poorly water-soluble drug. It does not dissolve well in the aqueous gastrointestinal fluid, which means it is not absorbed well via the oral route, because a drug can cross cell membranes when it is dissolved in the gastrointestinal fluid.

Objectives: The purpose of this research was to enhance the aqueous solubility and dissolution rate of eprosartan mesylate using the solid dispersion technique. Read More

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http://dx.doi.org/10.17219/pim/102976DOI Listing

Dialysis membranes: A 2018 update.

Polim Med 2018 Jan-Jun;48(1):57-63

Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Poland.

Dialysis membranes are the basic element of a hemodialyzer. Synthetic and natural materials characterized by various fiber arrangements are used in their production. The most up-to-date ones are made of synthetic polymers such as polyamide, phosphatidylserine (PS), polyacrylonitrile-based fiber (PAN), polyarylethersulfone, polyethersulfone, or polymethylmethacrylate. Read More

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http://dx.doi.org/10.17219/pim/102974DOI Listing
February 2019

Polyethylene terephthalate tape augmentation as a solution in recurrent quadriceps tendon ruptures.

Polim Med 2018 Jan-Jun;48(1):53-56

Division of Sports Medicine, Wroclaw Medical University, Poland.

Quadriceps tendon rupture is a severe and demanding problem in knee surgery, especially when it is recurrent and when elderly patients are involved. It can have a devastating impact when it is a complication following knee arthroplasty. There are many procedures for dealing with this problem, but none of them offer reliable results. Read More

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http://dx.doi.org/10.17219/pim/102977DOI Listing
February 2019

[Safety assessment of using collamer phakic implants in the correction of refractive errors].

Polim Med 2018 Jan-Jun;48(1):47-51

Katedra i Klinika Okulistyki, Wydział Lekarski Kształcenia Podyplomowego, Uniwersytet Medyczny we Wrocławiu, Polska.

Background: An increasing number of patients with refractive visual impairments, in whom the correction using spectacles or contact lenses does not meet expectations, consider the possibility of undergoing refractive surgery. Phakic implants are an alternative for patients who are not eligible for laser correction.

Objectives: The aim of the study is to assess the safety of using collamer phakic implants in the correction of vision defects during the annual follow-up. Read More

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http://dx.doi.org/10.17219/pim/102975DOI Listing
February 2019

Starch nanoparticles in drug delivery: A review.

Polim Med 2018 Jan-Jun;48(1):41-45

Department of Pharmaceutics and Industrial Pharmacy, University of Ibadan, Nigeria.

The uptake and specificity of drugs and the bioavailability of poorly soluble drugs has been improved by means of targeted drug delivery using nanoparticles. Many platforms have been used for nanoparticulate drug delivery and these include liposomes, polymer conjugates, metallic nanoparticles, polymeric micelles, dendrimers, nanoshells, and protein and nucleic acid-based nanoparticles. Starch is the 2nd most abundant natural polymer and has found wide use in drug delivery systems as binder, disintegrant and filler. Read More

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http://dx.doi.org/10.17219/pim/99993DOI Listing
January 2019
1 Read

Formulation and characterization of oral rapid disintegrating tablets of levocetirizine.

Polim Med 2018 Jan-Jun;48(1):31-40

Amity Institute of Pharmacy, Amity University, Noida, India.

Background: Levocetirizine, active R (-) enantiomer of cetirizine, is an orally active and selective H1 receptor antagonist used medically as an anti-allergic. Allergic rhinitis is a symptomatic disorder of the nose induced by inflammation mediated by immunoglobulin E (IgE) in the membrane lining the nose after allergen exposure.

Objectives: The purpose of the present study was to prepare rapidly disintegrating tablets of levocetirizine after its complexation with β-cyclodextrin (β-CD). Read More

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http://dx.doi.org/10.17219/pim/99951DOI Listing
January 2019
4 Reads

Porous starch and its application in drug delivery systems.

Polim Med 2018 Jan-Jun;48(1):25-29

Department of Internal Medicine and Clinic of Diseases of Horses, Dogs and Cats, Wrocław University of Environmental and Life Sciences, Poland.

In recent years, starch has become a new potential biomaterial for pharmaceutical applications. This biopolymer has unique physicochemical and functional characteristics, as well as various advantages such as low price, relative ease of isolation in pure form from the plant source, non-toxicity, biodegradability, good biocompatibility, and interaction with living cells. Starch is currently used in pharmacy as a binder, disintegrating agent, film-forming material, raw material for production of microspheres and nanoparticles, and a component of drug delivery systems. Read More

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http://www.polimery.umed.wroc.pl/en/article/2018/48/1/25/
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http://dx.doi.org/10.17219/pim/99799DOI Listing
January 2019
14 Reads

Preparation, characterization and in vitro evaluation of tablets containing microwave-assisted solid dispersions of apremilast.

Polim Med 2018 Jan-Jun;48(1):17-24

Discipline of Pharmacy, Graduate School of Health, University of Technology, Sydney, Australia.

Background: Solid dispersions are among the techniques successfully employed to enhance the dissolution of poorly water-soluble drugs. Microwave (MW)-assisted evaporative crystallization has been used to prepare solid dispersions of drugs and polymers.

Objectives: The aim of the study was to investigate the solubility of apremilast (APM) in water by exploring the effect of MW-assisted solid dispersion technology. Read More

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http://dx.doi.org/10.17219/pim/99801DOI Listing
January 2019
1 Read

A study of the effect of X-ray irradiation on the structure of Narafilcon A biopolymer soft contact lenses.

Polim Med 2018 Jan-Jun;48(1):11-16

Institute of Physics, Faculty of Mathematics and Natural Sciences, Jan Dlugosz University in Czestochowa, Poland.

Background: The effects of external factors such as X-ray irradiation on the structure and physical properties of contact lenses are very important for both the patients using contact lenses and medical personnel.

Objectives: The aim of the study was to investigate the effect of X-rays on the structure of Narafilcon A silicone-hydrogel contact lenses.

Material And Methods: In order to study the structural changes caused by X-rays in Narafilcon A polymer contact lenses, the following spectroscopy methods were used: positron annihilation lifetime spectroscopy (PALS), Fourier transform middle infrared spectroscopy (FTIR) and Raman spectroscopy (RS). Read More

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http://dx.doi.org/10.17219/pim/96288DOI Listing
November 2018
2 Reads

[Study of the structure of contact lenses using PALS, MIR and Raman spectroscopy in the regard of safety of persons exposed to ionizing radiation].

Polim Med 2018 Jan-Jun;48(1):5-9

Zakład Radioterapii, Wojewódzki Szpital Specjalistyczny im. Najświętszej Maryi Panny w Częstochowie, Polska.

Among patients and health professionals who are exposed to ionizing radiation during diagnostic and therapeutic procedures, refractive errors are common and soft contact lenses are widely used to correct them. Changes in the inner structure of contact lens may influence the safety of its usage through modification of its water content or oxygen accessibility to cornea. Therefore, analysis of impact of external factors, therein ionizing radiation used in medicine, on contact lenses parameters is necessary, particularly to compare the presence of free volume gaps in the structure of the polymer soft contact lenses. Read More

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http://dx.doi.org/10.17219/pim/96287DOI Listing
November 2018
2 Reads

Formulation and evaluation of controlled-release matrix systems of ciprofloxacin.

Polim Med 2017 Jul-Dec;47(2):101-106

Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Australia.

Background: Ciprofloxacin is a broad-spectrum fluoroquinolone antibacterial drug to which most Gram-negative and many Gram-positive bacteria are highly susceptible. Fluoroquinolones are administered repeatedly, twice a day for 5 days, during the course of therapy. Hence, they require repeated administration. Read More

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http://dx.doi.org/10.17219/pim/90020DOI Listing
November 2018
22 Reads

Light-cured dimethacrylate dental restorative composites under a prism of annihilating positrons.

Polim Med 2017 Jul-Dec;47(2):91-100

Department of Pediatric Dentistry, Danylo Halytsky Lviv National Medical University, Ukraine.

Background: Breakthrough resolutions in current biopolymer engineering rely on reliable diagnostics of atomic-deficient spaces over the finest sub-nanometer length scales. One such diagnostic is positron annihilation lifetime spectroscopy, which probes space-time continuum relationships for the interaction between electrons and their antiparticle (positrons) in structural entities like free-volume defects, vacancies, vacancy-like clusters, interfacial voids and pores, etc.

Objectives: This paper is intended to highlight the possibilities of positron annihilation lifetime spectroscopy as an informative instrumentation tool to parameterize free-volume evolution in light-cured dimethacrylate dental restorative composites exemplified by Charisma® (Heraeus Kulzer GmbH, Hanau, Germany) and Dipol® (Oksomat-AN Ltd, Kyiv, Ukraine). Read More

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http://dx.doi.org/10.17219/pim/81450DOI Listing
November 2018
14 Reads

Improving the solubility of nevirapine using A hydrotropy and mixed hydrotropy based solid dispersion approach.

Polim Med 2017 Jul-Dec;47(2):83-90

NKBR College of Pharmacy & Research Centre, Meerut, India.

Background: Nevirapine, an antiviral drug, is a potent reverse transcriptase inhibitor (NNRTI). It is used in combination with nucleoside analogues for treatment of HIV type-1 (HIV-1) infection and AIDS. Nevirapine is a BCS class II drug which shows dissolution rate limited absorption. Read More

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http://dx.doi.org/10.17219/pim/77093DOI Listing
November 2018
10 Reads

[Influence of electrochemical ageing on properties of chosen medical receptacles].

Polim Med 2017 Jul-Dec;47(2):77-82

Instytut Technologii Mechanicznych, Politechnika Częstochowska, Polska.

Background: Presently, most of receptacles used in medicine are made of polymeric materials. This is due to, e.g. Read More

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http://dx.doi.org/10.17219/pim/90021DOI Listing
November 2018
3 Reads

Kheri (Acacia chundra, family: Mimosaceae) gum: Characterization using analytical, mathematical and pharmaceutical approaches.

Polim Med 2017 Jul-Dec;47(2):65-76

Siddarth Institute of Pharmacy, Dehradun, Uttarkhand, India.

Background: Natural polymers have been used in medical, pharmaceutical, cosmetic and food industry. They should be characterized before their possible applications in different industries.

Objectives: The objective of this study was to characterize Kheri (Acacia chundra, family: Mimosaceae) gum using analytical, mathematical and pharmaceutical approaches. Read More

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http://dx.doi.org/10.17219/pim/76515DOI Listing
November 2018
2 Reads

Synthetic grafts in the treatment of ruptured anterior cruciate ligament of the knee joint.

Polim Med 2017 Jan-Jun;47(1):55-59

Division of Sports Medicine, Wroclaw Medical University, Wrocław, Poland.

The anterior cruciate ligament (ACL) is cited as the most frequently injured ligament in the knee. The standard treatment of ACL injury remains ligament reconstruction followed by a postoperative physiotherapeutic procedure. During the reconstruction, the torn ligament can be replaced with an autograft or an allograft. Read More

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http://dx.doi.org/10.17219/pim/76819DOI Listing
April 2018
10 Reads

Chitosan and its composites: Properties for use in bone substitution.

Polim Med 2017 Jan-Jun;47(1):49-53

Clinical Department of Traumatology and Hand Surgery, Wroclaw Medical University, Wrocław, Poland.

For many years, research has been carried out on finding an ideal bone substitute. Chitosan (CTS) is a naturally occurring polysaccharide, obtained mainly from, inter alia, the shells of crustaceans. It is characterized by its high level of biocompatibility, biodegradability and antimicrobial properties as well as its support in the healing of wounds. Read More

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http://dx.doi.org/10.17219/pim/76517DOI Listing
April 2018
6 Reads

The role of chitin and chitosan in peripheral nerve reconstruction.

Polim Med 2017 Jan-Jun;47(1):43-47

Department of Traumatology, Clinical Department of Traumatology and Hand Surgery, Wroclaw Medical University, Wrocław, Poland.

Chitin is a natural polysaccharide commonly found in nature and chitosan is its partially deacetylated derivative. The properties of both biopolymers allow their wide use in medicine and various industries. This paper presents the possibilities offered by chitin and chitosan for the creation of neurotubes utilized in peripheral nerve repair procedures. Read More

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http://dx.doi.org/10.17219/pim/75653DOI Listing
April 2018
6 Reads

Native and microwave-modified Terminalia mantaly gums as sustained-release and bioadhesive excipients in naproxen matrix tablet formulations.

Polim Med 2017 Jan-Jun;47(1):35-42

Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Olabisi Onabanjo University, Sagamu, Nigeria.

Background: Hydrophilic polymers provide a means of sustaining drug delivery. Native gums may be limited in function, but modification may improve their activity.

Objectives: The aim of the study was to evaluate native and modified forms of Terminalia mantaly gum for their sustained-release and bioadhesive properties. Read More

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http://dx.doi.org/10.17219/pim/76058DOI Listing
April 2018
18 Reads

Film forming properties of Cissus pulpunea (Guill and Perr) and Irvingia gabonensis (O'Rorke) gums.

Polim Med 2017 Jan-Jun;47(1):25-33

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria.

Background: Natural polymers such as gums have gained attention in drug delivery systems due to their availability, compatibility and degradation under natural and physiological conditions.

Objectives: The aim of the present study was to investigate the film forming properties of gums obtained from the stem of Cissus polpunea (Guill and Perr) and the seed of Irvingia gabonensis (O'Rorke).

Material And Methods: Gums were extracted from the relevant plant parts and characterized using functional, proximate and elemental properties. Read More

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http://dx.doi.org/10.17219/pim/76059DOI Listing
April 2018
29 Reads

Evaluation of two novel plant gums for bioadhesive microsphere and sustained-release formulations of metformin hydrochloride.

Polim Med 2017 Jan-Jun;47(1):13-23

Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, S.A.S. Nagar, India.

Background: The biological half life of metformin requires multiple doses which are associated with poor patient compliance. This justifies the need for a dosage form with reduced dosing frequency.

Objectives: Gums from Enterolobium cyclocarpum and Cedrela odorata trees were evaluated in formulating bioadhesive microspheres containing metformin hydrochloride, for sustained drug release. Read More

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http://dx.doi.org/10.17219/pim/74776DOI Listing
April 2018
5 Reads

Buccal patches of atenolol formulated using fenugreek (Trigonella foenum-graecum L.) seed mucilage.

Polim Med 2017 Jan-Jun;47(1):5-11

Department of Pharmaceutics, Seemanta Institute of Pharmaceutical Sciences, Mayurbhanj, Odisha, India.

Background: The use of mucoadhesive natural polymers in designing mucoadhesive patch systems has received much attention.

Objectives: The study involved the development and evaluation of buccal patches of atenolol using fenugreek (Trigonella foenum-graecum L.) seed mucilage with hydroxylpropyl methyl cellulose (HPMC K4M) and a backing membrane (ethyl cellulose 5% w/v). Read More

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http://dx.doi.org/10.17219/pim/70498DOI Listing
April 2018
5 Reads

A Retrospective Evaluation of Anatomical Reinsertion of the Distal Biceps Brachii Tendon Using an ACL TightRope® RT with a Titanium Cortical Button and Ultra High Molecular Weight Polyethylene Suture: A Preliminary Report.

Polim Med 2016 Jul-Dec;46(2):163-169

Department of Traumatology, Clinic of Traumatology and Hand Surgery, Wroclaw University Clinical Hospital, Wroclaw, Poland.

Background: Various surgical techniques for treating distal biceps brachii tendon injury have been described, and to date there is no consensus regarding the preferred fixation method for the anatomic reinsertion of the ruptured tendon.

Objectives: The aim of the study was to clinically and functionally evaluate the upper limb after surgical anatomic reinsertion of the distal biceps brachii tendon using an ACL TightRope® RT with a titanium cortical button and ultra high molecular weight polyethylene (UHMWPE) suture, and to assess postoperative complications.

Material And Methods: The sample comprised 3 patients. Read More

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http://dx.doi.org/10.17219/pim/0000DOI Listing
July 2017
9 Reads

Postoperative Knee Joint Stability Following Anterior Cruciate Ligament Reconstruction Using the Ligament Advanced Reinforcement System.

Polim Med 2016 Jul-Dec;46(2):155-161

Department and Clinic of Traumatology and Hand Surgery, Wroclaw Medical University, Wrocław, Poland.

Background: One of the goals of the synthetic materials used in knee joint reconstruction of the anterior cruciate ligament (ACL) is to improve the strength and stability of the graft immediately after the reconstruction. One of the synthetic grafts is a non-absorbable synthetic ligament device made of terephthalic polyethylene polyester fibers, the Ligament Advanced Reinforcement System (LARS).

Objectives: The aim of the study was to assess postoperative knee joint stability in patients who had undergone ACL reconstruction using the LARS graft. Read More

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http://dx.doi.org/10.17219/pim/68646DOI Listing
July 2017
3 Reads

[Application of synthetic and semisynthetic polymers (Kollidon K30 and hydroxypropylmethylcellulose) as carriers of ketoprofen in solid oral prolonged-release dosage forms].

Polim Med 2016 Jul-Dec;46(2):145-153

Zakład Technologii Postaci Leku, Uniwersytet Medyczny w Łodzi, Łódź, Polska.

Background: One of the most important challenges of the modern technology of solid oral dosage forms is to increase the effectiveness of the drug, reduce side effects and improve the comfort of use. One way to obtain such effects are prolonged release dosage forms.

Objectives: The aim of the study was to investigate the suitability of polymers (synthetic - Kollidon K30 and semisynthetic - hydroxypropyl methylcellulose), and calcium hydrogen phosphate dihydrate - as an inorganic insoluble filler - in the construction of the matrices of the solid oral dosage forms containing non-steroidal anti-inflammatory drugs (NSAIDs). Read More

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http://dx.doi.org/10.17219/pim/69296DOI Listing
July 2017
2 Reads

Histological Evaluation of the Local Soft Tissue Reaction After Implanting Resorbable and Non-resorbable Monofilament Fibers.

Polim Med 2016 Jul-Dec;46(2):135-143

Department of Experimental Surgery and Biomaterials Research, Wroclaw Medical University, Wroclaw, Poland.

Background: The development of technologies and scientific disciplines connected with medical implantation devices is dynamically affecting modern treatments by contemporary medicine and veterinary medicine; it also entails a need to monitor their impact on living organisms.

Objectives: The aim of the study was to conduct a comparative histological evaluation of the response of soft tissues after implanting monofilament fibers from resorbable glyconate and from non-resorbable polypropylene (PP) and polyamide (PA) in rats.

Material And Methods: Non-resorbable polyamide-based fibers were applied to skin anastomoses in rats. Read More

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http://dx.doi.org/10.17219/pim/68618DOI Listing
July 2017
8 Reads

The Effect of Curing Light Intensity on Free Volume Size in Some Dental Composites.

Polim Med 2016 Jul-Dec;46(2):129-133

University of Sistan and Baluchestan, Zahedan, Iran.

Background: Dental composite resins - reinforced polymers - are types of synthetic resins that are used in dentistry as restorative material or adhesives. The effect of curing-light intensity on free volume sizes of 4 commercial dental composites has been studied by means of the well-known positron annihilation lifetime spectroscopy technique.

Objectives: The aim of the study was to compare the photosensitivity of 4 commercial dimethacrylate-based dental composites. Read More

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http://dx.doi.org/10.17219/pim/68647DOI Listing
July 2017
5 Reads

Investigation and Optimization of the Effect of Polymers on Drug Release of Norfloxacin from Floating Tablets.

Polim Med 2016 Jul-Dec;46(2):117-127

Government College of Pharmacy, Osmanpura, Aurangabad, India.

Background: Norfloxacin is fluoroquinolone anti-infective used in the treatment of urinary tract infections, prostatitis, gonorrhea and genital tract infections. It has plasma half life of 3 to 4 h requiring multiple dosing in the treatment. Releaseretarding polymers can be used to modulate the drug release of norfloxacin. Read More

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http://dx.doi.org/10.17219/pim/68170DOI Listing
July 2017
7 Reads

The Stress Relaxation Process in Sutures Tied with a Surgeon's Knot in a Simulated Biological Environment.

Polim Med 2016 Jul-Dec;46(2):111-116

Institute of Applied Mechanics, Cracow University of Technology, Kraków, Poland.

Background: The exact characteristics of sutures are not only the basis for selecting from among different types of suture, but also provide the necessary information for the design of new surgical sutures. Apart from information relating to the breaking load of a suture reported in pharmacopoeias, the viscoelastic properties of sutures can be an additional selection criterium - one that influences stitching quality, especially when there is a risk of wound dehiscence.

Objectives: The aim of the study was to assess the stress relaxation process for 3 polymeric sutures in an environment simulating the conditions in a living organism and (for comparison) in room conditions. Read More

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http://dx.doi.org/10.17219/pim/68735DOI Listing
July 2017
5 Reads

[The Use of Polymers for Intraocular Lenses in Cataract Surgery].

Polim Med 2015 Jul-Dec;45(2):95-102

Katedra i Klinika Okulistyki Uniwersytetu Medycznego we Wrocławiu, Wrocław, Polska.

According to the World Health Organization, cataract remains the leading cause of the curable visual impairment worldwide. Cataract can only be cured by surgery during which the cloudy lens is replaced with an artificial intraocular lens. It is one of the most common surgeries being performed worldwide. Read More

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June 2016
7 Reads

[Metal-Organic Frameworks: A New Class of Mesoporous Materials and Potential Possibilities of Their Use in Pharmaceutical Technology].

Polim Med 2015 Jul-Dec;45(2):81-93

Katedra Technologii Postaci Leku i Biofarmacji, Collegium Medicum Uniwersytetu Jagiellońskiego, Kraków, Polska.

Metal-organic frameworks (MOFs) belong to the new class of mesoporous, hybrid materials composed of metal ions and organic binding ligands. Their unique features: wide range of chemical building components, which enables obtaining biocompatible materials, and high surface area and loading capacity, make them promising drug delivery vehicles for therapeutic agents. The ability to tune their structures and porosities provides better adjustment for adsorbed drug molecule. Read More

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June 2016
6 Reads

[The Use of Synthetic Polymers (Superdisintegrants) in Technology Tablets Containing Ethanol Dry Extract from Asparagus officinalis].

Polim Med 2015 Jul-Dec;45(2):73-80

Zakład Technologii Postaci Leku, Uniwersytet Medyczny w Łodzi, Łódź, Polska.

Background: Dry extracts are now frequently used in medicine as an alternative to synthetic drugs. In the case of tablet technology with dry plant extracts, the proper selection of disintegrants (superdisintegrants) is particularly important. Objectives. Read More

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June 2016
10 Reads

Effect of Calcium Chloride on Release Behavior of Babul (Acacia nilotica) gum Microbeads.

Polim Med 2015 Jul-Dec;45(2):67-72

Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, India.

Background: Oral delivery of drugs is the most common method, but due to the inability of drugs to restrain and localize in the gastro-intestinal tract, oral administration of drugs in conventional dosage forms have short-term limitations. Carrier technology may provide many approaches for the delivery of drugs by coupling the drug to a carrier particle, such as Microspheres, nanoparticles and liposomes, which modulate the release and absorption characteristics of the drug.

Objectives: The aim of this study was to prepare Diclofenac sodium microspheres using a natural polymer and show the effect of calcium chloride on the release behavior of microspheres. Read More

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June 2016
3 Reads

Development of Metronidazole-Loaded Colon-Targeted Microparticulate Drug Delivery System.

Polim Med 2015 Jul-Dec;45(2):57-65

Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, Tehsil-Dehra, Distt-Kangra, Himachal Pradesh, India.

Background: Crohn’s disease and ulcerative colitis are the main autoimmune inflammatory bowel diseases. Metronidazole is the most commonly used drug for the treatment of Crohn’s disease. However, the pharmacokinetic profile of this drug indicates that the largest amount of the drug is absorbed from the upper part of the intestines and very little concentration of the drugs reaches the colon. Read More

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June 2016
3 Reads

Influence of Polymer Type on the Physical Properties and Release Profile of Papaverine Hydrochloride From Hard Gelatin Capsules.

Polim Med 2015 Jul-Dec;45(2):51-5

Department of Applied Pharmacy, Medical University of Lublin, Lublin, Poland.

Background: The capsule is one of the most important solid dosage forms in the pharmaceutical industry. It is easier and faster to produce than a tablet, because it requires fewer excipients. Generally, capsules are easy to swallow and mask any unpleasant taste of the substances used while their release profiles can be easily modified. Read More

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June 2016
11 Reads

Polymers as Carriers of Gentamicin in Traumatology and Orthopedic Surgery - Current State Of Knowledge.

Polim Med 2016 Jan-Jun;46(1):101-104

University Clinical Hospital in Wroclaw, Wroclaw Medical University, Wrocław, Poland.

Osteomyelitis in patients undergoing surgery because of injuries and diseases of the musculoskeletal system is a serious clinical, economic and social problem. It is one of the greatest therapeutic challenges in traumatology and orthopedic surgery. To achieve the best results in the treatment of osteomyelitis, surgical debridement and intravenous antibiotic therapy is supported by local antibiotic delivery. Read More

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http://www.polimery.umed.wroc.pl/en/article/2016/46/1/101/
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http://dx.doi.org/10.17219/pim/65053DOI Listing
July 2017
10 Reads

Chemical Substances Used in the Treatment of Ganglions Located in the Hand and Wrist.

Polim Med 2016 Jan-Jun;46(1):95-100

Department of Traumatology, Clinical Department of Traumatology and Hand Surgery, Wroclaw Medical University, Wroclaw, Poland.

The aim of this work was to compare different chemical substances used in the treatment of ganglions located in the hand and wrist region. Their basic properties and mechanisms of action have been described. Moreover, the risks associated with the use of particular substances have been highlighted and potential complications connected with their administration have been discussed. Read More

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http://dx.doi.org/10.17219/pim/64803DOI Listing
July 2017
3 Reads

Corneal Cross-Linking: An Example of Photoinduced Polymerization as a Treatment Modality in Keratoconus.

Polim Med 2016 Jan-Jun;46(1):89-94

Department and Clinic of Ophthalmology, Wroclaw Medical University, Wroclaw, Poland.

The cornea is one of the principal refractive elements in the human eye and plays a crucial role in the process of vision. Keratoconus is the most common corneal dystrophy, found mostly among young adults. It is characterized by a reduced number of collagen cross-links in the corneal stroma, resulting in reduced biomechanical stability and an abnormal shape of the cornea. Read More

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http://dx.doi.org/10.17219/pim/65010DOI Listing
July 2017
10 Reads

Thermoplastic Elastomers: Materials for Heart Assist Devices.

Polim Med 2016 Jan-Jun;46(1):79-87

West Pomeranian University of Technology, Szczecin, Poland.

Heart assisting devices have become a standard element in clinical practice and provide support for the traditional methods of treating heart disease. Regardless of the construction of VAD (ventricular assist devices), there are crucial requirements that have to be met by the construction materials: high purity, desired physical, chemical and mechanical properties, easy fabrication and high stability and susceptibility to sterilization. They must not cause thrombosis, destroy cellular elements, alter plasma protein, destroy enzymes, deplete electrolytes, cause immune response and cancer, and must not produce toxic and allergic reactions, when they are applied in direct contact with biological tissues and fluids. Read More

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http://dx.doi.org/10.17219/pim/65099DOI Listing
July 2017
14 Reads

[Methods of Reduction of Warm Ischemic Time in Kidney Transplantation and Their Role of Early and Late Outcomes].

Polim Med 2016 Jan-Jun;46(1):71-77

Katedra i Klinika Chirurgii Naczyniowej, Ogólnej i Transplantacyjnej, Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu, Wrocław, Polska.

Kidney is the organ transplanted most often. An increase in the number of expanded criteria donors (ECD) has been observed for years, and consequently the condition of transplanted organs worsened. In recent years, the possibility to recover organs from donors after cardiac death (DCD) became legally available in Poland, which will result in the increase of donors. Read More

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http://www.polimery.umed.wroc.pl/en/article/2016/46/1/71/
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http://dx.doi.org/10.17219/pim/62901DOI Listing
July 2017
3 Reads

[Vascular System Infections: Characteristics, Risk Factors, Prevention Methods and Economic Impact].

Polim Med 2016 Jan-Jun;46(1):59-69

Wydział Elektrotechniki, Automatyki, Informatyki i Inżynierii Biomedycznej, Akademia Górniczo-Hutnicza im. S. Staszica w Krakowie, Kraków, Polska.

One of the main problems of modern medicine are infections. They can be divided into local and general (depending on infected tissues and/or organs) or hospital and community-acquired infections (depending on the location and source of infection). The occurrence of infection reduces the ability for quick recovery, and in case of complications the ability to continue professional activity. Read More

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http://dx.doi.org/10.17219/pim/64696DOI Listing
July 2017
4 Reads

Comparison of Bioabsorbable Interference Screws Composed of Poly-l-lactic Acid and Hydroxyapatite (PLLA-HA) to WasherLoc Tibial Fixation in Patients After Anterior Cruciate Ligament Reconstruction of the Knee Joint.

Polim Med 2016 Jan-Jun;46(1):53-58

Department of Traumatology, Clinic of Traumatology and Hand Surgery, Wroclaw Medical University, Wrocław, Poland.

Background: The reconstruction of the anterior cruciate ligament (ACL) of the knee joint is a standard in ACL complete rupture treatment in athletes. One of the weakest points of this procedure is tibial fixation of grafts.

Objectives: The aim was, firstly, to evaluate patients 3-4 years after primary ACL reconstruction with the use of autologous ipsilateral STGR grafts and with tibial fixation using a bioabsorbable interference screw composed of PLLA-HA or WasherLoc, comparing the postoperative result to the preoperative condition and, secondly, to compare the results between the two groups of patients with different tibial fixation. Read More

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http://dx.doi.org/10.17219/pim/65054DOI Listing
July 2017
4 Reads

Formulation and Evaluation of Oral Dissolving Films of Amlodipine Besylate Using Blends of Starches With Hydroxypropyl Methyl Cellulose.

Polim Med 2016 Jan-Jun;46(1):45-51

Department of Pharmaceutics and Industrial Pharmacy, University of Ibadan, Ibadan, Nigeria.

Background: Natural polymers serve as cheap, non-toxic, biocompatible excipients in oral drug delivery. These advantages inform their uses in the design of drug dosage forms.

Objectives: The aim of the study was to prepare and evaluate oral dissolving films of amlodipine besylate, an anti-hypertensive drug, using starch/polymer blends. Read More

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http://www.polimery.umed.wroc.pl/en/article/2016/46/1/45/
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http://dx.doi.org/10.17219/pim/65098DOI Listing
July 2017
5 Reads

Material and Compression Properties of Cedrela odorata Gum Co-Processed with Plantain Starch and Microcrystalline Cellulose.

Polim Med 2016 Jan-Jun;46(1):35-43

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria.

Background: Many excipients used in tableting exhibit some undesirable properties such as poor flow, cohesion and lubricating characteristics, thus necessitating some modification to achieve the desired product.

Objectives: The objective of this study was to enhance the material, flow and compressional properties of Cedrela odorata gum (COG) (Family: Meliaceae) by co-processing with plantain starch (PS) and microcrystalline cellulose (MCC).

Material And Methods: The COG was co-processed with PS (or MCC) by physical co-grinding at ratio 1 : 1, 1 : 2 and 1 : 4, and characterized using morphological analysis, swelling index viscosity measurements, particle size analysis and FTIR spectra. Read More

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http://dx.doi.org/10.17219/pim/64924DOI Listing
July 2017
3 Reads

Development of Ocular Delivery System for Glaucoma Therapy Using Natural Hydrogel as Film Forming Agent and Release Modifier.

Polim Med 2016 Jan-Jun;46(1):25-33

Meerut Institute of Engineering and Technology, Meerut, Uttar Pradesh, India.

Background: Glaucoma is characterized by increased intraocular pressure, which results in damage to the optic nerve. The existing therapy with conventional eye drops is inefficient due to nasolachrymal drainage, resulting in a reduced corneal residence of the drug.

Objectives: The objective was to develop controlled-release ocular films of timolol maleate using natural hydrogel from Tamarindus indica seeds as a sustaining and film-forming agent, to overcome the problems associated with eye drops. Read More

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http://dx.doi.org/10.17219/pim/63750DOI Listing
July 2017
10 Reads

Investigation of the Degree of Disorder of the Structure of Polymer Soft Contact Lenses Using Positron Annihilation Lifetime Spectroscopy PALS.

Polim Med 2016 Jan-Jun;46(1):17-23

Institute of Physics, Faculty of Mathematics and Natural Sciences, Jan Dlugosz University, Częstochowa, Poland.

Background: Hydrogel and silicone-hydrogel polymeric materials are widely used in ophthalmology for the manufacture of contact lenses. An important aspect is the investigation of the structure of these materials.

Objectives: This study has been conducted in order to compare the degree of disorder and presence of free volumes in the internal structure of the polymeric soft contact lenses Omafilcon A (hydrogel) and Comfilcon A (silicone-hydrogel). Read More

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http://dx.doi.org/10.17219/pim/62279DOI Listing
July 2017
9 Reads

Development of Bilayer Tablets with Modified Release of Selected Incompatible Drugs.

Polim Med 2016 Jan-Jun;46(1):5-15

School of Pharmaceutical Sciences, Shoolini University, Solan, Himachal Pradesh, India.

Background: The oral route is considered to be the most convenient and commonly-employed route for drug delivery. When two incompatible drugs need to be administered at the same time and in a single formulation, bilayer tablets are the most appropriate dosage form to administer such incompatible drugs in a single dose.

Objectives: The aim of the present investigation was to develop bilayered tablets of two incompatible drugs; telmisartan and simvastatin. Read More

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http://dx.doi.org/10.17219/pim/62511DOI Listing
July 2017
10 Reads

[Currently Recommended Restorative Materials in Modern Conservative Dentistry].

Polim Med 2015 Jan-Jun;45(1):37-43

Conservative treatment which restores the function, aesthetics and protects remaining tooth structure, and what is the most important, the viability of the tooth pulp, is still needed. Dental fillings replace specialized tissues of the tooth that have been lost due to caries or injury. Any decision concerning the use of a particular restorative material should be individualized and based on the competence regarding the composition, properties and characteristics of the specific restorative material. Read More

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December 2015
18 Reads

Comparison of Occurrence of Free Volumes for Rigid Gas Permeable and Soft Contact Lenses.

Polim Med 2015 Jan-Jun;45(1):31-5

Background: The polymeric materials: hydrogel, silicone--hydrogel and methacrylic acid are used in ophthalmology for the manufacture of contact lenses. It is important to research the structure of these materials, mainly the prevalence of free volumes.

Objectives: The study has been conducted in order to comparison the presence of free volume gaps in the structure of the polymer soft contact lenses: Etafilcon A (hydrogel), Narafilcon A (silicone-hydrogel) and the polymer rigid gas permeable (RGP) contact lens (Fluor-Silicon-Methacrylat-Copolymer). Read More

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December 2015
13 Reads