601,214 results match your criteria Point of Care: The Journal of Near-Patient Testing and Technology [Journal]


Maintenance of Integrity of Upper Facet Joints during Simulated Percutaneous Pedicle Screw Insertion Using 2D versus 3D Planning.

J Neurol Surg A Cent Eur Neurosurg 2019 Apr 24. Epub 2019 Apr 24.

Department of Neurosurgery, University of Mainz, Mainz, Germany.

Background:  No studies have directly and quantitatively compared two-dimensional (2D) and three-dimensional (3D) planning as applied during conventional percutaneous or navigated percutaneous pedicle screw placement.

Study Aims:  This lumbar pedicle-based stabilization simulation study aimed to investigate the risk of upper facet joint violation (FJV) during posterior percutaneous pedicle screw placement with conventional 2D planning of screw implantation (as a model for fluoroscopically guided screws) compared with 3D planning (as used with navigation techniques).

Methods:  The placement of monosegmental lumbar pedicle screws using the data sets of 250 consecutive patients was simulated. Read More

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http://dx.doi.org/10.1055/s-0039-1681042DOI Listing

Glucocorticoids and programming of the microenvironment in heart.

J Endocrinol 2019 Apr 1. Epub 2019 Apr 1.

L Zhang, Basic Sciences, Loma Linda University School of Medicine, Loma Linda, United States.

Glucocorticoids are primary stress hormones and can improve neonatal survival when given to pregnant women threatened by preterm birth or to preterm infants. It has become increasingly apparent that glucocorticoids, primarily through interacting with glucocorticoid receptors, play a critical role in late gestational cardiac maturation. Altered glucocorticoid actions contribute to the development and progression of heart disease. Read More

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http://dx.doi.org/10.1530/JOE-18-0672DOI Listing

Notch Signaling Mediates Secondary Senescence.

Cell Rep 2019 Apr;27(4):997-1007.e5

MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh, Edinburgh, UK. Electronic address:

Oncogene-induced senescence (OIS) is a tumor suppressive response to oncogene activation that can be transmitted to neighboring cells through secreted factors of the senescence-associated secretory phenotype (SASP). Currently, primary and secondary senescent cells are not considered functionally distinct endpoints. Using single-cell analysis, we observed two distinct transcriptional endpoints, a primary endpoint marked by Ras and a secondary endpoint marked by Notch activation. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.03.104DOI Listing

The Major Risk Factors for Alzheimer's Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques.

Cell Rep 2019 Apr;27(4):1293-1306.e6

VIB Centre for Brain Disease Research, Leuven, Belgium; University of Leuven, Department of Neurosciences and Leuven Brain Institute, Leuven, Belgium; UK Dementia Research Institute, University College London, London, UK. Electronic address:

Gene expression profiles of more than 10,000 individual microglial cells isolated from cortex and hippocampus of male and female App mice over time demonstrate that progressive amyloid-β accumulation accelerates two main activated microglia states that are also present during normal aging. Activated response microglia (ARMs) are composed of specialized subgroups overexpressing MHC type II and putative tissue repair genes (Dkk2, Gpnmb, and Spp1) and are strongly enriched with Alzheimer's disease (AD) risk genes. Microglia from female mice progress faster in this activation trajectory. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.03.099DOI Listing
April 2019
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Development of a Cx46 Targeting Strategy for Cancer Stem Cells.

Cell Rep 2019 Apr;27(4):1062-1072.e5

Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH 44195, USA; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA. Electronic address:

Gap-junction-mediated cell-cell communication enables tumor cells to synchronize complex processes. We previously found that glioblastoma cancer stem cells (CSCs) express higher levels of the gap junction protein Cx46 compared to non-stem tumor cells (non-CSCs) and that this was necessary and sufficient for CSC maintenance. To understand the mechanism underlying this requirement, we use point mutants to disrupt specific functions of Cx46 and find that Cx46-mediated gap-junction coupling is critical for CSCs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22111247193041
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http://dx.doi.org/10.1016/j.celrep.2019.03.079DOI Listing
April 2019
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Electrophysiological Evidence for Top-Down Lexical Influences on Early Speech Perception.

Psychol Sci 2019 Apr 24:956797619841813. Epub 2019 Apr 24.

Department of Psychological and Brain Sciences, Villanova University.

An unresolved issue in speech perception concerns whether top-down linguistic information influences perceptual responses. We addressed this issue using the event-related-potential technique in two experiments that measured cross-modal sequential-semantic priming effects on the auditory N1, an index of acoustic-cue encoding. Participants heard auditory targets (e. Read More

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http://dx.doi.org/10.1177/0956797619841813DOI Listing

Evaluation of AUDIT Consumption Items New Adaptation to Improve the Screening of College Students Binge Drinking.

Adicciones 2019 Mar 28;0(0):1145. Epub 2019 Mar 28.

Universidad Internacional de Valencia..

The strong presence of Binge Drinking (BD) amongst university students, as well as the consequences associated with the same and the changes taking place over recent years regarding its conceptualization make it necessary to examine the usefulness of screening instruments used to detect this drinking pattern. This study examines the usefulness of a briefer adaptation of the AUDIT proposed by Cortés, Giménez, Motos, and Sancerni (2017a).College students self-administered the AUDIT, the revised items 2 and 3 (A2r and A3r), and completed a weekly self-report of their alcohol intake. Read More

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http://dx.doi.org/10.20882/adicciones.1145DOI Listing

Convergence in health care spending across counties in New York from 2007 through 2016.

Authors:
Mark A Zezza

PLoS One 2019 24;14(4):e0215850. Epub 2019 Apr 24.

New York State Health Foundation, New York City, New York, United States of America.

Background: One approach considered for reducing health care spending is to narrow the gap in spending between high- and low-spending areas. The goal would be to reduce spending in the high areas to similar levels achieved in areas that use health care more efficiently. This paper examined the degree to which high-spending areas remain high-spending and which types of service lead to convergence or divergence in spending in New York State. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215850PLOS

Stakeholders' perceptions of protected area management following a nationwide community-based conservation reform.

PLoS One 2019 24;14(4):e0215437. Epub 2019 Apr 24.

Department of Arctic and Marine Biology, UIT-The Arctic University of Norway, Tromsø, Norway.

People's perceptions can point to reasons for conservation support or lack thereof. In this study, we surveyed the perceptions of conservation among local stakeholders who participated in protected area (PA) management following a reform towards community-based conservation in Norway. We analyzed the link between perceptions of threats to conservation values, prioritized management actions and trust in PA governance, and assessed how these perceptions aligned with the stakeholders' preferred overarching conservation approach and their support for PAs. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215437PLOS

Influences of demographic, seasonal, and social factors on automated touchscreen computer use by rhesus monkeys (Macaca mulatta) in a large naturalistic group.

PLoS One 2019 24;14(4):e0215060. Epub 2019 Apr 24.

Department of Psychology, Emory University, Atlanta, Georgia, United States of America.

Animals housed in naturalistic social groups with access to automated cognitive testing vary in whether and how much they participate in cognitive testing. Understanding how demographic, seasonal, and social factors relate to participation is essential to evaluating the usefulness of these systems for studying cognition and in assessing the data produced. We evaluated how sex, age, reproductive experience, seasonality, and rank related to patterns of participation in a naturalistic group of rhesus monkeys over a 4-year period. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215060PLOS

A kinetic model for Brain-Derived Neurotrophic Factor mediated spike timing-dependent LTP.

PLoS Comput Biol 2019 Apr 24;15(4):e1006975. Epub 2019 Apr 24.

Institute of Biophysics, National Research Council, Palermo, Italy.

Across the mammalian nervous system, neurotrophins control synaptic plasticity, neuromodulation, and neuronal growth. The neurotrophin Brain Derived Neurotrophic Factor (BDNF) is known to promote structural and functional synaptic plasticity in the hippocampus, the cerebral cortex, and many other brain areas. In recent years, a wealth of data has been accumulated revealing the paramount importance of BDNF for neuronal function. Read More

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http://dx.doi.org/10.1371/journal.pcbi.1006975DOI Listing

Defining a Core Data Set for Registry of Esophageal Atresia in the Northwest of Iran.

J Registry Manag 2018 ;45(3):132-135

Defining the core data set is the main step for establishing a registry system. The aim of this study was to define the core data set for the registry of esophageal atresia in the northwest of Iran.

Methods: First, the preliminary list of data elements was extracted from the related registries of other countries, as well as from the literature. Read More

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January 2018

Speech-Language Pathology and the Youth Offender: Epidemiological Overview and Roadmap for Future Speech-Language Pathology Research and Scope of Practice.

Authors:
Pamela C Snow

Lang Speech Hear Serv Sch 2019 Apr;50(2):324-339

La Trobe Rural Health School, Bendigo, Victoria, Australia.

Purpose This article is concerned with the growing body of international evidence indicating that adolescents in contact with the youth justice system are likely to have severely compromised oral language skills, receptively and expressively. A smaller, but persuasive, literature also points to poor literacy skills in this population. Language and literacy skills underpin academic, social, and vocational success ( C. Read More

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http://dx.doi.org/10.1044/2018_LSHSS-CCJS-18-0027DOI Listing

Validation of the Spanish Version of the Beginning Breastfeeding Survey-Cumulative: A Follow-up Study.

J Hum Lact 2019 Apr 24:890334419840003. Epub 2019 Apr 24.

2 Department of Nursing, University of Alicante, Alicante, Spain.

Background: The Beginning Breastfeeding Survey-Cumulative (BBSC) is an instrument that assesses the overall maternal perception of breastfeeding effectiveness during the early postpartum period.

Research Aims: The aims of this study were to adapt and validate a Spanish version of the BBSC and provide new evidence regarding its validity.

Methods: A standard forward and back-translation process was used to obtain the Spanish version of the questionnaire (BBSC-E). Read More

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http://dx.doi.org/10.1177/0890334419840003DOI Listing

From Molecular and Emulsified Ion Sensors to Membrane Electrodes: Molecular and Mechanistic Sensor Design.

Acc Chem Res 2019 Apr 24. Epub 2019 Apr 24.

University of Geneva , Department of Inorganic and Analytical Chemistry , Quai Ernest Ansermet 30 , Geneva 1211 , Switzerland.

Selective molecular ion probes are often insoluble in water and require a hydrophobic solvent environment for strong and selective binding, which runs counter to the desire of utilizing them in a homogeneous solution. This Account aims to guide the reader on how such molecules, often coined ionophores, can be harnessed to design exceptionally useful optical and electrochemical sensors. We start here with some historical context on the design of such ionophores and continue with the explanation of the response mechanism of optical and potentiometric sensors and the role of combined components to build a robust ion sensor. Read More

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http://dx.doi.org/10.1021/acs.accounts.9b00056DOI Listing
April 2019
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Magnetite Coated Boron Nitride Nanosheets for the Removal of Arsenic (V) from Water.

ACS Appl Mater Interfaces 2019 Apr 24. Epub 2019 Apr 24.

It is widely known that the existence of arsenic (As) in water negatively impacts the humans and the environment. We report the synthesis, characterization and application of boron nitride nanosheets (BNNSs) and Fe3O4 functionalized BNNS (BNNS-Fe3O4) nanocomposite for removal of As(V) ions from aqueous systems. The morphology, surface properties and compositions of synthesized nanomaterials were examined using scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray powder diffraction (XRD), surface area analysis, zero-point charge and magnetic moment determination. Read More

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http://dx.doi.org/10.1021/acsami.8b22401DOI Listing

Effect of UDP-glucuronosyltransferase 1A1 activity on risk for developing Gilbert's syndrome.

Kaohsiung J Med Sci 2019 Apr 24. Epub 2019 Apr 24.

Department of Clinical Pathology, Cathay General Hospital, Taipei, Taiwan.

Variations at the six nucleotides -3279 (T > G), -53 (A[TA] TAA > A[TA] TAA), 211 (G > A), 686 (C > A), 1091 (C > T), and 1456 (T > G) in the UDP-glucuronosyltransferase 1A1 (UGT1A1) gene were determined in 178 Taiwanese patients with Gilbert's syndrome and in 200 healthy adults. Every subject was classified as a genotype depending on variation status of the six nucleotides in the UGT1A1 gene. The UGT1A1 activity for each genotype was calculated and then those genotypes were divided into 10 subgroups (Q1~Q10) according to their UGT1A1 activities, by using 10% as an interval. Read More

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http://dx.doi.org/10.1002/kjm2.12077DOI Listing

Open-label study assessing the efficacy and tolerability of topical skin care and sun protection alone and in combination with intense pulsed light therapy.

J Cosmet Dermatol 2019 Apr 24. Epub 2019 Apr 24.

The Pearl Dermatology, Houston, Texas.

Background: Intense pulsed light therapy (IPL) decreases facial erythema and telangiectasias associated with rosacea. Topical skin care products decrease facial erythema by the action of active ingredients and masking effects.

Objectives: To assess the efficacy and tolerability of combining a topical skin care regimen (TSCR) comprised of a multifunctional three-in-one facial cream and a mineral-based brush-on SPF50 powder sunscreen with a single IPL treatment for treating mild-to-severe facial redness associated with rosacea. Read More

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http://dx.doi.org/10.1111/jocd.12952DOI Listing

Systematic experimental study on quantum sieving of hydrogen isotopes in metal-amide-imidazolate frameworks with narrow 1-D channels.

Chemphyschem 2019 Apr 24. Epub 2019 Apr 24.

Max-Planck-Institut fur Intelligente Systeme, Max-Planck-Institut für Intelligente Systeme, Heisenbergstr. 3, 70569, Stuttgart, GERMANY.

Quantum sieving of hydrogen isotopes is experimentally studied in isostructural hexagonal metal-organic frameworks having 1-D channels, named IFP-1, -3, -4 and -7. Inside the channels different molecules or atoms restrict the channel diameter periodically with apertures larger (4.2 Å for IFP-1, 3. Read More

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http://dx.doi.org/10.1002/cphc.201900183DOI Listing

A Multi-Institutional International Analysis of Textbook Outcomes Among Patients Undergoing Curative-Intent Resection of Intrahepatic Cholangiocarcinoma.

JAMA Surg 2019 Apr 24:e190571. Epub 2019 Apr 24.

The Ohio State University Wexner Medical Center, Columbus.

Importance: Composite measures may be superior to individual measures for the analysis of hospital performance and quality of surgical care.

Objective: To determine the incidence of a so-called textbook outcome, a composite measure of the quality of surgical care, among patients undergoing curative-intent resection of intrahepatic cholangiocarcinoma.

Design, Setting, And Participants: This cohort study involved an analysis of a multinational, multi-institutional cohort of patient from 15 major hepatobiliary centers in North America, Europe, Australia, and Asia who underwent curative-intent resection of intrahepatic cholangiocarcinoma between 1993 and 2015. Read More

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http://archsurg.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamasurg.2019.0571DOI Listing
April 2019
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Association of Rivaroxaban With Thromboembolic Events in Patients With Heart Failure, Coronary Disease, and Sinus Rhythm: A Post Hoc Analysis of the COMMANDER HF Trial.

JAMA Cardiol 2019 Apr 24. Epub 2019 Apr 24.

Universite de Lorraine, INSERM Unite 1116, Vandoeuvre les Nancy, France.

Importance: Whether anticoagulation benefits patients with heart failure (HF) in sinus rhythm is uncertain. The COMMANDER HF randomized clinical trial evaluated the effects of adding low-dose rivaroxaban to antiplatelet therapy in patients with recent worsening of chronic HF with reduced ejection fraction, coronary artery disease (CAD), and sinus rhythm. Although the primary end point of all-cause mortality, myocardial infarction, or stroke did not differ between rivaroxaban and placebo, there were numerical advantages favoring rivaroxaban for myocardial infarction and stroke. Read More

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http://dx.doi.org/10.1001/jamacardio.2019.1049DOI Listing

Serum C-reactive protein relationship in high- versus low-virulence pathogens in the diagnosis of periprosthetic joint infection.

J Med Microbiol 2019 Apr 24. Epub 2019 Apr 24.

1 Department of Orthopaedic Surgery, Helios ENDO-Klinik Hamburg, Holstenstrasse 2, 22767 Hamburg, Germany.

Little is known about the relationship between the virulence of pathogens in periprosthetic joint infection (PJI) and C-reactive protein (CRP) levels. In this context, we assessed the performance of CRP for PJI. We collected the following data from 987 cases of total joint revision due to PJI and 386 cases of aseptic revision: age, gender, comorbidities, values for serum CRP, leukocytes, microbiology for preoperatively taken aspirations and at least 2 intraoperative biopsies, and presence or absence of a draining sinus. Read More

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http://dx.doi.org/10.1099/jmm.0.000958DOI Listing

To What Extent Are Main Accident-Insurer Cases Representative of All Significantly Injured? A Swiss Monocenter Perspective.

J Insur Med 2019 Apr 24. Epub 2019 Apr 24.

2   Amsler Consulting, Gundeldingerrain 111,CH-4059 Basel (FA).

Even though Switzerland has a compulsory insurance system, there is a lack of detailed information on the treatment and outcome following trauma. The objective of this evaluation was to examine to what extent cases insured by the largest accident-insurer (Suva) are representative of all significantly injured. Trauma center analysis of all ≥16 year old trauma patients with a New Injury Severity Score (NISS) ≥8, comparing the characteristics of Suva- vs non-Suva cases (chi-square; univariate explained variance R; multivariate logistic regression analysis, Nagelkerke R). Read More

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http://dx.doi.org/10.17849/insm-48-1-1-14.1DOI Listing

Effects of dry needling in the sternocleidomastoid muscle on cervical motor control in patients with neck pain: a randomised clinical trial.

Acupunct Med 2019 Apr 24:964528419843913. Epub 2019 Apr 24.

3 Nursing and Physical Therapy Department, Institute of Biomedicine (IBIOMED), Universidad de León, León, Spain.

Objective: To determine the changes produced by trigger point dry needling (TrP-DN) of sternocleidomastoid in patients with neck pain, and to observe how it might modify cervical motor control (CMC).

Design: Single-centre, randomised, double-blinded clinical trial.

Setting: Participants were recruited through advertising. Read More

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http://journals.sagepub.com/doi/10.1177/0964528419843913
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http://dx.doi.org/10.1177/0964528419843913DOI Listing
April 2019
3 Reads

Giant Primary Retroperitoneal Serous Cystadenoma: A Rare Entity Mimicking Multiple Neoplastic and Nonneoplastic Processes.

Arch Pathol Lab Med 2019 Apr 24. Epub 2019 Apr 24.

From the Department of Pathology and Laboratory Medicine, Penn State Health Milton S. Hershey Medical Center, Hershey, Pennsylvania (Dr Chen); the Department of Pathology, Moffitt Cancer Center, Tampa, Florida (Dr Jiang); and the Department of Oncologic Sciences, University of South Florida College of Medicine, Tampa (Dr Jiang).

Serous cystadenoma, often known as ovarian serous cystadenoma, is one of the common benign ovarian neoplasms. On the other hand, primary retroperitoneal serous cystadenoma is an extremely rare benign entity whose pathogenesis has not been well understood. Clinical presentation and symptomatology vary greatly and are highly dependent on the size and location of the lesion. Read More

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http://dx.doi.org/10.5858/arpa.2018-0245-RSDOI Listing

All-In-One "Schizophrenic" Self-Assembly of Orthogonally Tuned Thermoresponsive Diblock Copolymers.

Langmuir 2019 Apr 24. Epub 2019 Apr 24.

Fachgebiet Physik weicher Materie/Lehrstuhl für Funktionelle Materialien, Physik-Department , Technische Universität München , James-Franck-Straße 1 , 85748 Garching , Germany.

Smart, fully orthogonal switching was realized in a highly biocompatible diblock copolymer system with variable trigger-induced aqueous self-assembly. The polymers are composed of nonionic and zwitterionic blocks featuring lower and upper critical solution temperatures (LCSTs and UCSTs). In the system investigated, diblock copolymers from poly( N-isopropyl methacrylamide) (PNIPMAM) and a poly(sulfobetaine methacrylamide), systematic variation of the molar mass of the latter block allowed for shifting the UCST of the latter above the LCST of the PNIPMAM block in a salt-free condition. Read More

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http://dx.doi.org/10.1021/acs.langmuir.9b00241DOI Listing

Development of The ReaxFF Reactive Force Field for Inherent Point Defects in the Si/Silica System.

J Phys Chem A 2019 Apr 24. Epub 2019 Apr 24.

We redeveloped the ReaxFF force field parameters for Si/O/H interactions that enable Molecular Dynamics (MD) simulations of Si/SiO 2 interfaces and O-diffusion in bulk Si at high temperatures, in particular with respect to point defect stability and migration. Our calculations show that the new force field framework (ReaxF F present ) which was guided by the extensive Quantum Mechanics (QM)-based training set de- scribes correctly the underlying mechanism of the O-migration in Si network, namely, the diffusion of O in bulk Si occurs by jumping between the neighboring bond-centered sites along a path in the (110) plane, and during the jumping, O goes through the asymmetric transition state at the split site. Additionally, the ReaxF F present predicts the diffusion barrier of O-interstitial in the bulk Si of 64. Read More

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http://dx.doi.org/10.1021/acs.jpca.9b01481DOI Listing

Solid state ionics of hybrid halide perovskites.

J Am Chem Soc 2019 Apr 18. Epub 2019 Apr 18.

Many exciting "anomalies" affecting long-time and low-frequency phenomena in the photo-active halide perovskites that are presently in the focus of the field of photovoltaics turn out to be rather expected from the point of view of Solid State Ionics. This paper discusses such issues based on the mixed conducting nature of these materials, and indicates how the Solid State Ionics toolbox can be used to condition and potentially improve these solids. In addition to equilibrium bulk properties, interfacial effects and light effects on the mixed conductivity are considered. Read More

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http://dx.doi.org/10.1021/jacs.8b13594DOI Listing

Bioinspired Thiophosphorodichloridate Reagents for Chemoselective Histidine Bioconjugation.

J Am Chem Soc 2019 Apr 24. Epub 2019 Apr 24.

Department of Chemistry , University of California , Berkeley , California 94720 , United States.

Site-selective bioconjugation to native protein residues is a powerful tool for protein functionalization, with cysteine and lysine side chains being the most common points for attachment owing to their high nucleophilicity. We now report a strategy for histidine modification using thiophosphorodichloridate reagents that mimic post-translational histidine phosphorylation, enabling fast and selective labeling of protein histidines under mild conditions where various payloads can be introduced via copper-assisted alkyne-azide cycloaddition (CuAAC) chemistry. We establish that these reagents are particularly effective at covalent modification of His-tags, which are common motifs to facilitate protein purification, as illustrated by selective attachment of polyarginine cargoes to enhance the uptake of proteins into living cells. Read More

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http://dx.doi.org/10.1021/jacs.8b11912DOI Listing

Effect of site-directed point mutations on protein misfolding: A simulation study.

Proteins 2019 Apr 24. Epub 2019 Apr 24.

Department of Chemistry, University of Delhi, Delhi-110007, India.

A Monte Carlo simulation based sequence design method is proposed to investigate the role of site-directed point mutations in protein misfolding. Site-directed point mutations are incorporated in the designed sequences of selected proteins. While most mutated sequences correctly fold to the their native conformation, some of them stabilize in other non-native conformations and thus misfold/unfold. Read More

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http://dx.doi.org/10.1002/prot.25702DOI Listing

Strengthening nursing surveillance in general wards: a practice development approach.

J Clin Nurs 2019 Apr 24. Epub 2019 Apr 24.

Conjoint Associate Professor, Metro North Hospital and Health Service, Herston QLD, Australia.

Aim: To explore the context and culture of nursing surveillance on an acute care ward.

Background: Prevention of patient deterioration is primarily a nursing responsibility in hospital. Registered nurses make judgements and act on emerging threats to patient safety through a process of nursing surveillance. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jocn.14890
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http://dx.doi.org/10.1111/jocn.14890DOI Listing
April 2019
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An overview of the Brazilian contributions to Green Analytical Chemistry.

An Acad Bras Cienc 2019 18;91(suppl 1):e20180294. Epub 2019 Apr 18.

Centro de Energia Nuclear na Agricultura, Universidade de São Paulo, Avenida Centenário, 303, 13400-970 Piracicaba, SP, Brazil.

Green Analytical Chemistry (GAC) is a research field that seeks for more sustainable analytical approaches to minimize the toxicity and amounts of wastes without hindering the analytical performance. This is a trend in Analytical Chemistry worldwide and because of the diversity of innovations on this subject, Brazil stands out as the third in the list of the main contributors to GAC, with ca. 11. Read More

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http://dx.doi.org/10.1590/0001-3765201920180294DOI Listing

Plastic recovery and self-healing in longitudinally twinned SiGe nanowires.

Nanoscale 2019 Apr 24. Epub 2019 Apr 24.

Department of Mechanical and Industrial Engineering, University of Illinois at Chicago, Chicago, IL 60607, USA.

This paper reports on plastic recovery and self-healing behavior in longitudinally-twinned and [112] orientated SiGe nanowire (NW) beams when they are subjected to large bending strains. The NW alloys are comprised of lamellar nanotwin platelet(s) sandwiched between two semi-cylindrical twins. The loading curves, which are acquired from atomic force microscope (AFM) based three-point bending tests, reveal the onset of plastic deformation at a characteristic stress threshold, followed by further straining of the NWs. Read More

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http://dx.doi.org/10.1039/c9nr02073jDOI Listing

Prospective Study of the Radiolabeled GRPR Antagonist BAY86-7548 for Positron Emission Tomography/Computed Tomography Imaging of Newly Diagnosed Prostate Cancer.

Eur Urol Oncol 2019 Mar 22;2(2):166-173. Epub 2018 Sep 22.

Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Background: Current imaging techniques may not detect all prostate cancer (PCa) lesions.

Objective: To evaluate positron emission tomography (PET)/computed tomography (CT) using the radiolabeled GRPR antagonist probe BAY86-7548 (Ga-RM2) for localization of newly diagnosed PCa in comparison with multiparametric magnetic resonance imaging (mpMRI), histopathology, and immunohistochemistry (IHC).

Design, Setting, And Participants: This was a prospective study of 16 men with biopsy-proven PCa (2 low, 8 intermediate, and 6 high risk). Read More

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http://dx.doi.org/10.1016/j.euo.2018.08.011DOI Listing

The Learning Curve for Magnetic Resonance Imaging/Ultrasound Fusion-guided Prostate Biopsy.

Eur Urol Oncol 2019 Mar 17;2(2):135-140. Epub 2018 Aug 17.

Department of Urology, New York Presbyterian Hospital, Weill Cornell Medical College, New York, NY, USA. Electronic address:

Background: Magnetic resonance imaging/ultrasound-guided fusion biopsy (FBx) is more accurate at detecting clinically significant prostate cancer than conventional transrectal ultrasound-guided systematic biopsy. However, learning curves for attaining accuracy may limit the generalizability of published outcomes.

Objective: To delineate and quantify the learning curve for FBx by assessing the targeted biopsy accuracy and pathological quality of systematic biopsy over time. Read More

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http://dx.doi.org/10.1016/j.euo.2018.07.005DOI Listing

Multiple Praziquantel Treatments of Egg-Negative, CCA-Positive Schoolchildren in a Very Low Endemic Setting in Egypt Do Not Consistently Alter CCA Results.

Am J Trop Med Hyg 2019 Apr 22. Epub 2019 Apr 22.

National Nutrition Institute, General Organization for Teaching Hospitals and Institutes, Cairo, Egypt.

Forty-four egg-negative/circulating cathodic antigen (CCA) low-positive (trace or 1+) children in three districts of very low prevalence in Egypt were given three sequential praziquantel (PZQ) treatments. Stool and urine specimens were collected 3 months following the initial treatment, and 3 weeks following the second and following the third PZQ treatments, which were conducted 5 weeks apart. Stool specimens were examined by Kato-Katz (four slides/stool sample) and all egg-negative stools were further tested by the "miracidia hatching test" (MHT). Read More

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http://dx.doi.org/10.4269/ajtmh.18-0961DOI Listing

Evaluation of an Emergency Bulk Chlorination Project Targeting Drinking Water Vendors in Cholera-Affected Wards of Dar es Salaam and Morogoro, Tanzania.

Am J Trop Med Hyg 2019 Apr 22. Epub 2019 Apr 22.

Emergency Response and Recovery Branch, Division of Global Health Protection, U.S. Centers for Disease Control and Prevention, Atlanta, Georgia.

In August 2015, an outbreak of cholera was reported in Tanzania. In cholera-affected areas of urban Dar es Salaam and Morogoro, many households obtained drinking water from vendors, who sold water from tanks ranging in volume from 1,000 to 20,000 L. Water supplied by vendors was not adequately chlorinated. Read More

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http://www.ajtmh.org/content/journals/10.4269/ajtmh.18-0734
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http://dx.doi.org/10.4269/ajtmh.18-0734DOI Listing
April 2019
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Using informatics to improve healthcare quality.

Authors:
Ahmed Otokiti

Int J Health Care Qual Assur 2019 Mar;32(2):425-430

Harlem Hospital Center, New York, New York, USA.

Purpose: The purpose of this paper is to provide insights into contemporary challenges associated with applying informatics and big data to healthcare quality improvement.

Design/methodology/approach: This paper is a narrative literature review.

Findings: Informatics serve as a bridge between big data and its applications, which include artificial intelligence, predictive analytics and point-of-care clinical decision making. Read More

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http://dx.doi.org/10.1108/IJHCQA-03-2018-0062DOI Listing

Intervention analysis and classification: key to health outcomes optimization.

Authors:
Oguchi Nkwocha

Int J Health Care Qual Assur 2019 Mar;32(2):347-359

Clinica de Salud del Valle de Salinas (CSVS), Salinas, California, USA.

Purpose: Measures are important to healthcare outcomes. Outcome changes result from deliberate selective intervention introduction on a measure. If measures can be characterized and categorized, then the resulting schema may be generalized and utilized as a framework for uniquely identifying, packaging and comparing different interventions and probing target systems to facilitate selecting the most appropriate intervention for maximum desired outcomes. Read More

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http://dx.doi.org/10.1108/IJHCQA-03-2018-0066DOI Listing

Visuo-haptic transfer for object recognition in children with periventricular leukomalacia and bilateral cerebral palsy.

Child Neuropsychol 2019 Apr 24:1-14. Epub 2019 Apr 24.

a Department of Developmental Neuroscience , IRCCS Stella Maris Foundation , Pisa , Italy.

Object recognition is a complex adaptive process that can be impaired in children with neurodevelopmental disabilities. Recently, we found a significant effect of time on the development of unimodal and crossmodal recognition skills for common objects in typical children and this was a starting point for the study of visuo-haptic object recognition skills in impaired populations. In this study, we investigated unimodal visual information, unimodal haptic information and visuo-haptic information transfer in 30 children, from 4. Read More

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http://dx.doi.org/10.1080/09297049.2019.1602599DOI Listing

Effect of School Services on Academic Performance After Traumatic Brain Injury in Hispanic and Non-Hispanic Students.

J Sch Health 2019 Apr 23. Epub 2019 Apr 23.

Epidemiology and Pediatric Dentistry, University of Washington, Harborview Injury Prevention and Research Center, 401 Broadway, 4th Floor, Seattle, WA 98122.

Background: School reintegration after traumatic brain injuries (TBI) requires school support; however, implementation of services is complex. This study evaluates disparities in receipt of school services for Hispanic children and its effect on academic performance.

Methods: Secondary analyses of school data on receipt of pre- and post-TBI school services. Read More

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http://dx.doi.org/10.1111/josh.12776DOI Listing

The Role and Study of Mitochondrial Impairment and Oxidative Stress in Cholestasis.

Methods Mol Biol 2019 ;1981:117-132

Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

The blockage of bile flow, cholestasis, could lead to serious clinical outcomes, including severe liver injury. Accumulation of the cytotoxic molecules, such as bile acids, during cholestasis, not only impairs liver function, but also affects other organs, including the kidneys. Although the precise mechanisms of cytotoxicity and organ injury in cholestasis are far from clear, oxidative stress and its subsequent events seem to play a central role in this complication. Read More

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http://dx.doi.org/10.1007/978-1-4939-9420-5_8DOI Listing
January 2019
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A markerless automatic deformable registration framework for augmented reality navigation of laparoscopy partial nephrectomy.

Int J Comput Assist Radiol Surg 2019 Apr 23. Epub 2019 Apr 23.

Department of Urology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100730, China.

Purpose Video see-through augmented reality (VST-AR) navigation for laparoscopic partial nephrectomy (LPN) can enhance intraoperative perception of surgeons by visualizing surgical targets and critical structures of the kidney tissue. Image registration is the main challenge in the procedure. Existing registration methods in laparoscopic navigation systems suffer from limitations such as manual alignment, invasive external marker fixation, relying on external tracking devices with bulky tracking sensors and lack of deformation compensation. Read More

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http://dx.doi.org/10.1007/s11548-019-01974-6DOI Listing

New treatment-induced adverse effects we need to learn as modern hepatologists.

Authors:
Yoshiyuki Ueno

Hepatol Int 2019 Apr 23. Epub 2019 Apr 23.

Department of Gastroenterology, Faculty of Medicine Yamagata University, 2-2-2 Iidanishi, Yamagata, 9909585, Japan.

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http://dx.doi.org/10.1007/s12072-019-09947-2DOI Listing

Optimal Cut-off Point of Waist to Height Ratio in Beijing and Its Association with Clusters of Metabolic Risk Factors.

Curr Med Sci 2019 Apr 23;39(2):330-336. Epub 2019 Apr 23.

Department of Epidemiology and Biostatistics, School of Public Health, Capital Medical University, Beijing, 100069, China.

A host of studies found waist-to-height ratio (WHtR) having higher diagnostic value than other abdominal obesity anthropometric indicators for metabolic disorders. But the cut-off points are still not consistent. This study was aimed to explore the optimal cut-off point of WHtR in Chinese population and identify the association between WHtR and cluster of metabolic risk factors. Read More

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http://dx.doi.org/10.1007/s11596-019-2039-xDOI Listing

Efficacy of Long-term Selenium Supplementation in the Treatment of Chronic Keshan Disease with Congestive Heart Failure.

Curr Med Sci 2019 Apr 23;39(2):237-242. Epub 2019 Apr 23.

Department of Human Anatomy and Histo-Embryology, School of Medicine, Xi'an Jiaotong University, Xi'an, 710061, China.

Few effective treatments for chronic Keshan disease have been available till now. The efficacy of long-term selenium supplementation in the treatment of chronic Keshan disease with congestive heart failure is inconclusive. This study aimed to determine whether selenium supplementation is associated with a decreased risk of cardiac death in chronic Keshan disease with congestive heart failure by ten years of follow-up. Read More

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http://dx.doi.org/10.1007/s11596-019-2025-3DOI Listing
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