586,620 results match your criteria Point of Care: The Journal of Near-Patient Testing and Technology [Journal]


Early-Stage Translational Research in Perinatal Medicine.

Neonatology 2018 Dec 6;115(2):182-188. Epub 2018 Dec 6.

Liggins Institute, University of Auckland, Auckland, New

Background: Pre-clinical research, which encompasses studies in animals and in the laboratory, has made significant contributions to the improvement of neonatal outcomes.

Methods: Here, we describe examples of how pre-clinical research can be the starting point on the journey to the development of new interventions to improve neonatal care and outcomes and discuss recent progress in ensuring methodological and ethical rigour in pre-clinical research involving animal models.

Results: Studies in pregnant sheep led to the serendipitous discovery that preterm lambs born after exogenous corticosteroid exposure were able to aerate their lungs. Read More

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December 2018
3 Reads

Direct Effect of Septic Plasma in Human Cell Lines Viability.

Blood Purif 2018 Dec 6:1-7. Epub 2018 Dec 6.

Department of Nephrology, Dialysis and Transplant, San Bortolo Hospital, Vicenza, Italy.

Background: Sepsis is a life-threatening condition often associated with a high incidence of multiple organs injury. Several papers suggested the immune response by itself, with the production of humoral inflammatory mediators, is crucial in determining organ injury. However, little is known of how sepsis directly induces organ injury at the cellular levels. Read More

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December 2018
1 Read

Occurrence and levels of micropollutants across environmental and engineered compartments in Austria.

J Environ Manage 2018 Dec 3;232:636-653. Epub 2018 Dec 3.

Institute for Water Quality and Resource Management, TU Wien, Karlsplatz 13/226, 1040, Vienna, Austria.

Occurrence and concentration of a broad spectrum of micropollutants are investigated in Austrian river catchments, namely polycyclic aromatic hydrocarbons (PAHs), polybrominated diphenyl ethers (PBDEs), organotin compounds, perfluoroalkyl acids (PFAAs) and metals. The parallel analysis across multiple environmental and engineered compartments sheds light on the ratio of dissolved and particulate transport and on differences in concentration levels between point and diffuse emission pathways. It is found that some PAHs and organotins are present in rivers, groundwater and bulk deposition at higher concentrations than in municipal wastewater effluents. Read More

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December 2018
1 Read

Quality improvement: A practical nursing program's admission test.

Nurse Educ Today 2018 Nov 29;73:65-70. Epub 2018 Nov 29.

Department of Child Health, School of Medicine, University of Missouri, 430 Sinclair School of Nursing, University of Missouri, Columbia, MO 65211, United States of America. Electronic address:

Introduction: Academic institutions are under pressure to maintain a nearly flawless retention rate, while graduating successful students. The use of standardized admission tests to provide data driven decisions regarding applicant selection is common. The varying reliability and validity of current standardized tests inspired a large Canadian academic institution to use a faculty developed admission test for admission to its practical nursing (PN) program. Read More

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November 2018
2 Reads

The prevalence and prognostic value of myelin oligodendrocyte glycoprotein antibody in adult optic neuritis.

J Neurol Sci 2018 Nov 28;396:225-231. Epub 2018 Nov 28.

Department of Ophthalmology, Military General Hospital of Beijing PLA, Beijing, China. Electronic address:

Background And Objective: Adult demyelinating optic neuritis (ON) with positive myelin-oligodendrocyte glycoprotein antibody (MOG-Ab) has distinct clinical features. This study aimed to investigate the point prevalence, relationship with steroid dependency and prognosis value of MOG-Ab in adult ON.

Methods: Clinical data analysis was undertaken in adults with ON admitted between December 2014 and January 2016. Read More

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November 2018
1 Read

Phyllodes tumors of the breast. The treatment results for 340 patients from a single cancer centre.

Breast 2018 Nov 26;43:85-90. Epub 2018 Nov 26.

Department of Surgical Oncology, Centre of Oncology, Maria Sklodowska-Curie Memorial Institute, Cracow Branch, ul. Garncarska 11, 31-115 Cracow, Poland.

Purpose: The primary treatment of choice for patients with phyllodes tumor of the breast (PTB) is surgery. Two major problems regarding the treatment of such patients remain unclear: what is the appropriate surgical margin and what role is played by adjuvant radiotherapy (ART).

Methods: The study provides a retrospective review of all patients with PTB treated between 1952 and 2013 at a single institute. Read More

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November 2018
1 Read

Pharmaceutical cocrystals: from serendipity to design to application.

Drug Discov Today 2018 Dec 3. Epub 2018 Dec 3.

Synthesis and Solid State Pharmaceutical Centre (SSPC), Bernal Institute, University of Limerick, Limerick, Ireland. Electronic address:

The field of pharmaceutical cocrystals has reached a tipping point, particularly because cocrystals can improve the physicochemical properties of drugs without compromising their therapeutic benefit. Accounts of cocrystal investigations in the literature started in earnest in 2003 and patent applications soon followed. The frequency of both has steadily accelerated, demonstrating an enhanced understanding of the design, characterisation, and manufacture of cocrystals and heightened interest from industry. Read More

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December 2018
3 Reads

Peri-Procedural Antithrombotic Management from a Patient Perspective: A Qualitative Analysis.

Am J Med 2018 Dec 3. Epub 2018 Dec 3.

Center for Bioethics and Social Science in Medicine, University of Michigan, Ann Arbor, MI; Frankel Cardiovascular Center, University of Michigan, Ann Arbor, MI. Electronic address:

Background: Peri-procedural antithrombotic medication management is a complex, often confusing process for patients and their providers. Communication difficulties often lead to suboptimal medication management resulting in delayed or cancelled procedures.

Methods: We conducted telephone surveys with patients taking chronic antithrombotic medications who had recently undergone an endoscopy procedure. Read More

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December 2018
3 Reads

Myocardial Injury in Critically Ill Patients with Community-acquired Pneumonia: A Cohort Study.

Ann Am Thorac Soc 2018 Dec 6. Epub 2018 Dec 6.

University Medical CenterUtrecht, Utrecht, Netherlands.

Rationale: Myocardial injury, as reflected by elevated cardiac troponin levels in plasma, is common in patients with community-acquired pneumonia (CAP), but its temporal dynamics and etiology remain unknown.

Objectives: Our aim was to determine the incidence of troponin release in patients with CAP and identify risk factors which may point to underlying etiologic mechanisms.

Methods: We included consecutive patients admitted with severe CAP to two intensive care units in the Netherlands between 2011 and 2015. Read More

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December 2018
1 Read

A Single-Step Gold Nanoparticle-Blood Serum Interaction Assay Reveals Humoral Immunity Development and Immune Status of Animals from Neonates to Adults.

ACS Infect Dis 2018 Dec 6. Epub 2018 Dec 6.

A well-developed, functional immune system is paramount to combat harmful attack from pathogenic organisms and prevent infectious diseases. Newborn animals and humans have only limited immunity upon birth, but their immune functions are expected to develop within weeks to months and eventually to reach a maturity that will provide full protection. Despite the importance of immune activity in animal and human health management, there is no convenient test available that allows for rapid assessment of the state of immune function in non-laboratory settings. Read More

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December 2018

Visual inspection and dermoscopy, alone or in combination, for diagnosing keratinocyte skin cancers in adults.

Cochrane Database Syst Rev 2018 Dec 3;12:CD011901. Epub 2018 Dec 3.

Institute of Applied Health Research, University of Birmingham, Birmingham, UK, B15 2TT.

Background: Early accurate detection of all skin cancer types is important to guide appropriate management, to reduce morbidity and to improve survival. Basal cell carcinoma (BCC) is almost always a localised skin cancer with potential to infiltrate and damage surrounding tissue, whereas a minority of cutaneous squamous cell carcinomas (cSCCs) and invasive melanomas are higher-risk skin cancers with the potential to metastasise and cause death. Dermoscopy has become an important tool to assist specialist clinicians in the diagnosis of melanoma, and is increasingly used in primary-care settings. Read More

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December 2018
3 Reads

Dermoscopy, with and without visual inspection, for diagnosing melanoma in adults.

Cochrane Database Syst Rev 2018 Dec 3;12:CD011902. Epub 2018 Dec 3.

Institute of Applied Health Research, University of Birmingham, Birmingham, UK, B15 2TT.

Background: Melanoma has one of the fastest rising incidence rates of any cancer. It accounts for a small percentage of skin cancer cases but is responsible for the majority of skin cancer deaths. Although history-taking and visual inspection of a suspicious lesion by a clinician are usually the first in a series of 'tests' to diagnose skin cancer, dermoscopy has become an important tool to assist diagnosis by specialist clinicians and is increasingly used in primary care settings. Read More

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December 2018
6 Reads

Reflectance confocal microscopy for diagnosing cutaneous melanoma in adults.

Cochrane Database Syst Rev 2018 Dec 3;12:CD013190. Epub 2018 Dec 3.

Institute of Applied Health Research, University of Birmingham, Birmingham, UK, B15 2TT.

Background: Melanoma has one of the fastest rising incidence rates of any cancer. It accounts for a small percentage of skin cancer cases but is responsible for the majority of skin cancer deaths. Early detection and treatment is key to improving survival; however, anxiety around missing early cases needs to be balanced against appropriate levels of referral and excision of benign lesions. Read More

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December 2018
4 Reads

Accuracy of a Dynamic Dental Implant Navigation System in a Private Practice.

Int J Oral Maxillofac Implants 2018 Dec 5. Epub 2018 Dec 5.

Purpose: To evaluate the in vivo accuracy of dental implants placed using a dynamic computer-aided dental implant (CAI) navigation system. The impact of various factors on accuracy was also analyzed.

Materials And Methods: A retrospective, in vivo study was performed during the period of October 2015 to December 2017. Read More

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December 2018
1 Read

Chinese adolescents' power distance value and prosocial behavior toward powerful people: A longitudinal study.

PLoS One 2018 6;13(12):e0208473. Epub 2018 Dec 6.

Department of Psychology, School of Sociology and Psychology, Central University of Finance and Economics, Beijing, China.

We were interested in how specific cultural value and adolescent social behavior would influence each other over time. Thus the present study explored the longitudinal and bidirectional relations between adolescents' power distance value and prosocial behavior toward powerful people over a year. A sample of 434 Chinese adolescents participated in the investigation (initial mean age = 11. Read More

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December 2018
4 Reads

Association of pre-eclampsia risk with maternal levels of folate, homocysteine and vitamin B12 in Colombia: A case-control study.

PLoS One 2018 6;13(12):e0208137. Epub 2018 Dec 6.

Farr Institute of Health Informatics, University College London, London, United Kingdom.

Background: Maternal serum concentrations of folate, homocysteine, and vitamin B12 have been associated with pre-eclampsia. Nevertheless, reported studies involve limited number of cases to reliably assess the nature of these associations. Our aim was to examine the relation of these three biomarkers with pre-eclampsia risk in a large Colombian population. Read More

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December 2018
1 Read

Platelet to lymphocyte ratio predicts all-cause mortality in patients with carotid arterial disease.

Rom J Intern Med 2018 Dec 1. Epub 2018 Dec 1.

TOBB Economy and Technology University, Cardiology Department, Ankara, Turkey.

Background: Platelet to lymphocyte ratio (PLR) has been demonstrated as an risk and prognostic marker in many of cardiovascular diseases. Relationship between PLR and severity of carotid stenosis has been shown. The aim of our study was to investigate the relationship between PLR and all cause mortality in patients with carotid arterial disease. Read More

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December 2018

Cannabinoid exposure and altered DNA methylation in rat and human sperm.

Epigenetics 2018 Dec 6. Epub 2018 Dec 6.

b Department of Psychiatry and Behavioral Sciences , Duke University Medical Center , Durham . NC 27705 , USA.

Little is known about the reproductive effects of paternal cannabis exposure. We evaluated associations between cannabis or tetrahydrocannabinol (THC) exposure and altered DNA methylation in sperm from humans and rats, respectively. DNA methylation, measured by reduced representation bisulfite sequencing, differed in the sperm of human users from non-users by at least 10% at 3,979 CpG sites. Read More

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December 2018
5 Reads

Assessing the Performance of the Nonbonded Mg2+ Models in a Two-metal-dependent Ribonuclease.

J Chem Inf Model 2018 Dec 6. Epub 2018 Dec 6.

Magnesium ions (Mg2+), abundant in living cells, are essential for biomolecular structure, dynamics, and function. The biological importance of Mg2+ has motivated continuous development and improvement of various Mg2+ models for molecular dynamics (MD) simulations during the last decades. There are four types of nonbonded Mg2+ models: the point charge models based on a 12-6 or 12-6-4 type Lennard-Jones (LJ) potential, and the multisite models based on a 12-6 or 12-6-4 LJ potential. Read More

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December 2018
1 Read

Abdominal tuberculosis in renal transplant recipient. Presentation of a case and literature review

Rev Med Inst Mex Seguro Soc 2018 11 30;56(4):414-417. Epub 2018 Nov 30.

Instituto Mexicano del Seguro Social, Hospital de Especialidades "Dr. Bernardo Sepúlveda Gutiérrez", Unidad de Investigación Médica en Enfermedades Nefrológicas. Ciudad de México, México

Background: Kidney transplantation presents a susceptible point, and is related to infections; tuberculosis is a common and endemic etiology in a country like Mexico, where the most frequent presentation is the respiratory condition, the extrapulmonary is extremely rare and it is derived from immunosuppression conditions.

Case Report: 33-year-old man with kidney disease of undetermined etiology, kidney transplant in 2003 (donor mother) with adequate evolution; presented with chronic graft nephropathy, with baseline creatinine of 1.8 mg / dL, immunosuppression with prednisone 10 mg every 24 hours, mycophenolate mofetil 500 mg every 8 hours and ciclosporin 100 mg every 12 hours; surgical intervention was performed due to acute abdomen, appendectomy and omentectomy with histopathological finding of tuberculosis, Dotbal, antiproliferative in suspension was started and decrease of calcineurin inhibitor. Read More

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November 2018

Evaluation of magnesium alloys for use as an intraluminal tracheal for pediatric applications in a rat tracheal bypass model.

J Biomed Mater Res B Appl Biomater 2018 Dec 6. Epub 2018 Dec 6.

Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, 15261.

Tracheal stenting currently using non-degradable stents is commonplace for treatment of trauma, prolonged intubation related adult airway obstructions, and pediatric patients-associated tracheal stenosis conditions. Degradable tracheal stent placement will avoid complications of stent removal and restenosis. Widespread reports exist on degradable magnesium alloys success for orthopedic and cardiovascular applications but none to date for intra tracheal use. Read More

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December 2018
1 Read

RAD-seq data reveal a cryptic Viburnum species on the North American Coastal Plain.

Syst Biol 2018 Dec 6. Epub 2018 Dec 6.

Department of Ecology and Evolutionary Biology, Yale University, New Haven, USA.

Species are the starting point for most studies of ecology and evolution, but the proper circumscription of species can be extremely difficult in morphologically variable lineages, and there are still few convincing examples of molecularly-informed species delimitation in plants. We focus here on the Viburnum nudum complex, a highly variable clade that is widely distributed in eastern North America. Taxonomic treatments have mostly divided this complex into northern (V. Read More

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December 2018
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Possible cold-adaptation for the fungal kinesin in compensation for thermal stability acquired by single amino acid substitution.

J Biochem 2018 Dec 5. Epub 2018 Dec 5.

Department of Biosciences, College of Humanities and Sciences, Nihon University, 3-25-40 Sakurajosui, Setagaya-ku, Tokyo, Japan.

The amino acid sequence of the motor domain of AnKinA, kinesin-1 from Aspergillus nidulans, growing optimally at 37°C, was compared with that of SbKin1, kinesin-1 from the snow mold Sclerotinia borealis. For cold-adaptation, some enzymes are thought to exhibit augmented protein structure flexibility, acquired most effectively by substituting a glycine residue for another amino acid residue. By the comparison described above, two glycine residues proximal to tightly-bound ADP were identified in the SbKin1 motor domain, of which the corresponding residues of AnKinA were non-glycine ones (P60 and S323). Read More

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December 2018
1 Read

Reproductive homeostasis and senescence in Drosophila melanogaster.

J Gerontol A Biol Sci Med Sci 2018 Dec 6. Epub 2018 Dec 6.

Dept. of Ecology, Evolution, & Behavior University of Minnesota - Twin Cities St. Paul, MN.

The homeostatic properties of reproduction in aging female Drosophila melanogaster are investigated. Classic studies based on cohort analysis suggest that homeostatic capacity declines gradually as daily oviposition rates decline in aging flies. Analysis at the level of individuals gives a very different picture: reproductive homeostasis remains relatively constant for most of adult life until a critical point when oviposition either ceases entirely or continues in dysregulated fashion. Read More

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December 2018

MODELLING γ-H2AX FOCI INDUCTION TO MIMIC LIMITATIONS IN THE SCORING TECHNIQUE.

Radiat Prot Dosimetry 2018 Dec 6. Epub 2018 Dec 6.

Physics Department, University of Pavia, Pavia, Italy.

An approach based on track-structure calculations has been developed to take account of artefacts occurring during γ-H2AX foci detection in 2D images of samples analyzed through immunocytochemistry. The need of this works stems from the observed saturation in foci yields measured after X-ray doses higher than few grays, hindering an unambiguous quantification of DNA damage and of radiation effectiveness. The proposed modelling approach allows to simulate the observer's point of view for foci scoring, mimicking the selection of a slice Δz of the cell nucleus due to the microscope depth of field, and applying a clustering algorithm to group together damages within a resolution parameter r. Read More

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December 2018
1 Read

Association of Chemoradiotherapy With Outcomes Among Patients With Stage I to II vs Stage III Small Cell Lung Cancer: Secondary Analysis of a Randomized Clinical Trial.

JAMA Oncol 2018 Dec 6:e185335. Epub 2018 Dec 6.

Division of Cancer Sciences, University of Manchester, Manchester, United Kingdom.

Importance: There is limited evidence to guide stage I to II small cell lung cancer (SCLC) treatment.

Objective: To examine the characteristics and outcomes among patients with stage I to II SCLC treated with modern chemoradiotherapy.

Design, Setting, And Participants: In this post hoc secondary analysis of the Concurrent Once-Daily vs Twice-Daily Radiotherapy Trial (CONVERT), a multicenter phase 3 trial conducted in patients with limited-stage SCLC from April 7, 2008, to November 29, 2013, patients with TNM stage I to II SCLC were compared with those with stage III disease. Read More

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December 2018
1 Read

Association Between Noninfectious Uveitis and Psychological Stress.

JAMA Ophthalmol 2018 Dec 6. Epub 2018 Dec 6.

Francis I. Proctor Foundation, University of California, San Francisco.

Importance: Uveitis involves dysregulation of the ocular immune system. Stress has been shown to affect immune function, but it is unclear whether there is an association between stress and uveitis.

Objective: To determine whether having uveitis is associated with psychological stress. Read More

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December 2018
2 Reads

Sources of Variation in the Adult Flight of Walnut Husk Fly (Diptera: Tephritidae): A Phenology Model for California Walnut Orchards.

Environ Entomol 2018 Dec 6. Epub 2018 Dec 6.

Department of Environmental Science, Policy and Management, University of California Berkeley, 130 Mulford Hall, Berkeley, CA 94720-3114.

A phenology model of the walnut husk fly, Rhagoletis completa Cresson, was developed to more accurately predict the timing of the flight period and optimize management decisions. A data set of 153 orchard years in which adults were trapped throughout the season was used for the development and validation of this model. Data from California Irrigation Management Information System (CIMIS) weather stations were used to match orchard-year datasets with historical climatic data on degree-day (DD) accumulation, winter chill, and winter rainfall. Read More

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December 2018

Shell model extension to the valence force field: application to single-layer black phosphorus.

Phys Chem Chem Phys 2018 Dec 6. Epub 2018 Dec 6.

Department of Physics, Applied Physics, and Astronomy, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.

We propose an extension of the traditional valence force field model to allow for the effect of electronic polarization to be included in the inter-atomic potential. Using density functional theory as a reference, this model is parameterized for the specific case of single-layer black phosphorus by fitting the phonon dispersion relation over the entire Brillouin zone. The model is designed to account for the effect of induced dipole interaction on the long-wavelength (|q[combining right harpoon above]| → 0) modes for the case of homopolar covalent crystals. Read More

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December 2018

Direct sampling mass spectrometry for clinical analysis.

Analyst 2018 Dec 6. Epub 2018 Dec 6.

State Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instrument, Tsinghua University, Beijing, 100084, China and Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA and Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA.

Direct sampling mass spectrometry (MS) has been advancing aggressively, showing immense potential in translating MS into the clinical field. Unlike traditional MS analysis involving extensive sample preparation and chromatographic separation, quick and simple procedures with minimal sample pretreatment or purification became available with direct sampling. An overview of the development in this field is provided, including some representative ambient ionization and fast extraction methods. Read More

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December 2018

High-sensitivity troponin T is a prognostic marker of hemodynamic instability in patients undergoing valve surgery.

Biomark Med 2018 Dec 6. Epub 2018 Dec 6.

Department of Acquired Cardiac Defects, Institute of Cardiology, Warsaw, Poland.

Aim: The usefulness of high-sensitivity troponin T (hs-TnT) as a predictor of perioperative hemodynamic instability is currently unknown.

Methods: A prospective study was conducted on a group of 708 consecutive patients with significant valvular heart disease that underwent elective valve surgery. The primary end point was postoperative hemodynamic instability. Read More

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December 2018

The usefulness of selected biomarkers in patients with valve disease.

Biomark Med 2018 Dec 6. Epub 2018 Dec 6.

Department of Acquired Cardiac Defects, Institute of Cardiology,  Warsaw, Poland.

Aim: The aim of the study was to investigate the prognostic value of selected biomarkers in patients undergoing valve surgery.

Materials & Methods: A prospective study was conducted on a group of consecutive patients with hemodynamically significant valve defects that underwent elective valve repair or replacement surgery. The primary end point was any major adverse event including death within 30 days. Read More

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December 2018
2 Reads

Cytometric Micro-Bead Magnetic Suspension Array for High-Throughput Ultra-Sensitive Detection of Aflatoxin B1.

Anal Chem 2018 Dec 6. Epub 2018 Dec 6.

High-throughput and low-cost detection of mycotoxins in complex matrices is becoming increasingly urgent but still challenged for ultra-sensitive analyses. Here we reported a green and practical cytometric micro-bead magnetic suspension array (CBMSA) strategy for rapid and economical detection of aflatoxin B1 (AFB1) in multiple batches of lotus seeds samples. The protocol included the fabrication of the suspension array chips by immobilizing the biotin-modified bovine serum albumin-AFB1 (antigen) onto the surface of streptavidin-coated magnetic micro-beads in a multi-wells array, the indirect immuno-competition of antigen and target of AFB1 in lotus seed samples with the specific antibodies, the rapid magnetic separation regardless complex pretreatment steps, and the ultra-sensitive fluorescence detection of fluorescein isothiocyanate labeled goat anti-mouse immunoglobulin G (FITC-IgG) probes. Read More

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December 2018
2 Reads

High probability areas for ASF infection in china along the russian and korean borders.

Transbound Emerg Dis 2018 Dec 6. Epub 2018 Dec 6.

Center of Conservation Medicine & Ecological Safety, Northeast Forestry University, Harbin, 150040, Heilongjiang province, P. R. China.

African swine fever (ASF) is a transcontinental, contagious, fatal virus disease of pig with devastating socioeconomic impacts. Interaction between infected wild boar and domestic pig may spread the virus. The disease is spreading fast from the west of Eurasia towards ASF-free China. Read More

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December 2018

Solving for X: Evidence for sex-specific autism biomarkers across multiple transcriptomic studies.

Am J Med Genet B Neuropsychiatr Genet 2018 Dec 6. Epub 2018 Dec 6.

Centre for Pattern Recognition and Data Analytics (PRaDA), Deakin University, Geelong, Australia.

Autism spectrum disorder (ASD) is a markedly heterogeneous condition with a varied phenotypic presentation. Its high concordance among siblings, as well as its clear association with specific genetic disorders, both point to a strong genetic etiology. However, the molecular basis of ASD is still poorly understood, although recent studies point to the existence of sex-specific ASD pathophysiologies and biomarkers. Read More

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December 2018
1 Read

Digital versatile discs as platforms for multiplexed genotyping based on selective ligation and universal microarray detection.

Analyst 2018 Dec 6. Epub 2018 Dec 6.

Departamento de Química, Universitat Politècnica de València, Camino de Vera s/n, E46022, Valencia, Spain. and Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València-Universitat de València, Valencia, Spain and Unidad Mixta UPV-La Fe, Nanomedicine and Sensors, IIS La Fe, Valencia, Spain.

The development of a high-performance assay readout using integrated detectors is a current challenge in the implementation of DNA tests in diagnostic laboratories, particularly for supporting pharmacogenetic tests. A method for allelic discrimination, associated with single nucleotide polymorphisms (SNPs), is presented. Genomic DNA is extracted from blood and buccal swab samples. Read More

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December 2018
1 Read

Effect of preservation methods on tensile properties of human femur-ACL-tibial complex (FATC) - a cadaveric study on male subjects.

Acta Bioeng Biomech 2018 ;20(4):31-42

Centre for Biomedical Engineering, Indian Institute of Technology (IIT) Delhi, New Delhi, India.

Purpose: Deep freezing and storing in formalin are some of the common techniques of human tissue preservation. However, the preservation modes affect the biomechanical properties of the tissues. In this work, the effects of the above-stated preservation tech- niques are compared with that of fresh cadaveric samples. Read More

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January 2018

Temporarily quadrupling the dose of inhaled steroid to prevent asthma exacerbations: FAST.

Health Technol Assess 2018 Dec;22(70):1-82

Respiratory Medicine, Nottingham NIHR Biomedical Research Centre, University of Nottingham, Nottingham, UK.

Background: Asthma exacerbations affect the quality of life of patients with asthma and have a major effect on the overall costs of asthma care. An asthma self-management plan that advises the temporary quadrupling of inhaled corticosteroid dose may prevent asthma exacerbations, but this needs to be confirmed before being adopted widely.

Objectives: To compare the clinical effectiveness and cost-effectiveness of an asthma self-management plan that advises patients to temporarily quadruple the dose of inhaled corticosteroid when asthma control starts to deteriorate with a standard self-management plan. Read More

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December 2018

The interaction of HIV set-point viral load and subtype on disease progression.

AIDS Res Hum Retroviruses 2018 Dec 6. Epub 2018 Dec 6.

NIAID, LIR , 855 North Wolfe St. , Rangos Building, Room 538A , Baltimore, Maryland, United States , 21205.

HIV-1 subtype and viral load set-point have been implicated as strong predictors of HIV-1 disease progression; however the relationship between these two variables has not been investigated. We used data from the Rakai Community Cohort Study to investigate whether the association between viral load set-point and disease progression is modified by HIV subtype. Time to AIDS or AIDS-related death was investigated through Cox proportional hazards regression with an interaction term between viral load set point and HIV subtype. Read More

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December 2018
1 Read

Highly Efficient Hydrogen Production via a Reformed Electrolysis System Driven by One Single Perovskite Solar Cell.

ChemSusChem 2018 Dec 5. Epub 2018 Dec 5.

Huazhong University of Science & Technology, Wuhan National Laboratory for Optoelectronics, 1037 Luoyu Road, Wuhan, China, 430074, Wuhan, China, CHINA.

Highly efficient hydrogen production by photovoltaic-driven electrolysis system requires low overpotential of electrolyzer and high couple efficiency of both components. Herein, we firstly propose Ni5P4 as cost-effective bifunctional electrocatalyst for hydrogen evolution and hydrazine oxidation in a reformed electrolyzer and experimentally validated that the electrolytic overpotential can be significantly reduced via replacing oxygen evolution reaction with hydrazine oxidation reaction at the anode. Furthermore, we conceive a novel scenario for hydrogen production by utilization of a low-cost and stable perovskite solar cell featuring with carbon back electrode to drive a reformed electrolyzer. Read More

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December 2018
1 Read

Critical review of emergency department management of chemotherapy complications in cancer patients.

Eur J Cancer Care (Engl) 2018 Dec 5:e12974. Epub 2018 Dec 5.

Melbourne School of Health Sciences, The University of Melbourne, Carlton, Victoria, Australia.

Introduction: Recent worldwide advances in cancer therapies have resulted in an increased number of people receiving chemotherapy in ambulatory care settings. In Spain, emergency departments are the single point of entry to acute inpatient services and they play a pivotal role in the management of chemotherapy complications. Little research exists in patterns of emergency department utilisation by oncology patients with chemotherapy-related complications. Read More

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December 2018

A two-tier standard method to test the toxicity of microplastics in marine water using Paracentrotus lividus and Acartia clausi larvae.

Environ Toxicol Chem 2018 Dec 5. Epub 2018 Dec 5.

ECIMAT, Universidade de Vigo, Illa de Toralla, E-36331, Vigo, Galicia.

A two-tier standardized protocol was designed in order to test the toxicity of microplastics to planktonic organisms. The protocol uses sea-urchin (Paracentrotus lividus) and copepod (Acartia clausi) larvae since they are common biological models in marine research, and standard methods for toxicity testing with regulatory applications are available. In Tier I, leachates obtained at a 100:1 liquid to solid ratio are tested, and toxic units (TU) are calculated using a probit dose:response model in order to quantify the toxicity of the plastics. Read More

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December 2018

Improvements in Lipid Suppression for 1H NMR-based Metabolomics: Applications to Solution-state and HR-MAS NMR-natural and in vivo samples.

Magn Reson Chem 2018 Dec 5. Epub 2018 Dec 5.

Environmental NMR Centre, Dept. of Physical and Environmental Sciences, University of Toronto, Scarborough, 1265 Military Trail, Toronto, ON, Canada, M1C 1A4.

Proton NMR spectra of intact biological samples often show strong contributions from lipids which overlap with signals of interest from small metabolites. Pioneering work by Diserens et al. demonstrated that the relative differences in diffusivity and relaxation of lipids verses small metabolites could be exploited to suppress lipid signals, in HR-MAS NMR spectroscopy. Read More

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December 2018
1 Read

Comprehensive analysis of presurgical factors predicting psychiatric disorders in patients with refractory temporal lobe epilepsy and mesial temporal sclerosis underwent cortico-amygdalohippocampectomy.

J Clin Lab Anal 2018 Dec 5:e22724. Epub 2018 Dec 5.

Department of Neurosurgery, Hospital of Chengdu Office of People's Government of Tibetan Autonomous Region, Chengdu, China.

Background: This study aimed to evaluate the predictive value of presurgical factors for psychiatric disorders (PD) in refractory temporal lobe epilepsy and mesial temporal sclerosis (TLE-MTS) patients underwent cortico-amygdalohippocampectomy (CAH).

Methods: A total of 98 refractory TLE-MTS patients underwent CAH were consecutively enrolled in this cohort study. Several presurgical factors were recorded, such as married status, employment status, highest education, disease duration, family history of epilepsy, and disorganized VEEG background activity. Read More

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December 2018

Passive sampling of pesticides and polychlorinated biphenyls (PCBs) along the Quequén Grande River watershed (Argentina).

Environ Toxicol Chem 2018 Dec 5. Epub 2018 Dec 5.

Laboratorio de Ecotoxicología y Contaminación Ambiental, Instituto de Investigaciones Marinas y Costeras (IIMyC), Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata (UNMdP) - Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Deán Funes 3350, Mar del Plata, 7600, Argentina.

Water monitoring is of great importance, especially for waterbodies in agricultural or industrial areas. Grab sampling is a widely used technique for aquatic monitoring but represents only a snapshot of the contaminant levels at a specific point in time. Passive sampling, on the other hand, is an integrative technique which provides an average concentration of contaminants representative for its deployment period. Read More

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December 2018
1 Read

V. MATERNAL SENSITIVITY AND CO-CONSTRUCTION SKILLS: CONCURRENT AND LONGITUDINAL ASSOCIATIONS WITH PRESCHOOLERS' SECURE BASE BEHAVIOR.

Monogr Soc Res Child Dev 2018 Dec;83(4):74-90

This study investigated the associations among maternal sensitivity, maternal secure base script co-construction skills, and children's secure base behavior during early childhood. Maternal sensitivity and children's secure base behavior were assessed in naturalistic settings among 81 mother-child dyads when the children were approximately 3.5 years old. Read More

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December 2018
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