593,843 results match your criteria Point of Care: The Journal of Near-Patient Testing and Technology [Journal]


Ultrasound-Guided Botulinum Toxin Injections into the Salivary Glands for the Treatment of Drooling.

Isr Med Assoc J 2019 Feb;21(2):116-119

Department of Oral and Maxillofacial Surgery, Sheba Medical Center, Tel Hashomer, affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: Drooling is the unintentional loss of saliva from the mouth, usually caused by poor coordination of the swallowing mechanism. It is commonly seen in patients with chronic neurologic disorders, such as Parkinson's disease, amyotrophic lateral sclerosis (ALS), cerebral palsy, and stroke, as well as in patients with cognitive impairment and dementia.

Objectives: To evaluate the efficacy and safety of ultrasound-guided botulinum toxin injections into the parotid and submandibular salivary glands for the treatment of drooling. Read More

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February 2019

VaccHemInf project: protocol for a prospective cohort study of efficacy, safety and characterisation of immune functional response to vaccinations in haematopoietic stem cell transplant recipients.

BMJ Open 2019 Feb 15;9(2):e026093. Epub 2019 Feb 15.

Département des Maladies Infectieuses et Tropicales, Hospices Civils de Lyon, Lyon, France.

Introduction: Immune reconstitution after haematopoietic stem cell transplantation (HSCT) is a complex and dynamic process, varying from a state of nearly complete immunosuppression to an expected full immune recovery. Specific vaccination guidelines recommend reimmunisation after HSCT but data regarding vaccine efficacy in this unique population are scarce. New immune functional assays could enable prediction of vaccine response in the setting of HSCT. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026093DOI Listing
February 2019

Review: The role of zinc in the endocrine system.

Pak J Pharm Sci 2019 Jan;32(1):231-239

Selcuk University, Medical School, Department of Physiology, Konya, Turkey.

Zinc is essential in the regulation of a variety of physiological and biochemical events in the organism. It plays a critical role in maintaining the cell membrane integrity, protein-carbohydrate-lipid metabolism, immune system, wound injury and in the regulation of a number of other biological processes associated with normal growth and development. Physiological and biochemical levels of many hormones are affected by zinc metabolism. Read More

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January 2019

Healing effects of Pergularia tomentosa L., a native medicinal plant in Bushehr province, Iran on burn, in animal model.

Pak J Pharm Sci 2019 Jan;32(1):21-28

Department of Marine Toxinology, The Persian Gulf Marine Biotechnology Research Center, Bushehr University of Medical Sciences, Bushehr, Iran.

Burn injury is one of the most destructive events in the world. The Pergularia tomentosa L. is a medicinal plant that traditionally, applies for treatment of burning, in Bushehr province, Iran. Read More

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January 2019

Histopathology mapping of biochemical changes in diffuse axonal injury by FTIR micro-spectroscopy.

Leg Med (Tokyo) 2019 Feb 2;37:76-82. Epub 2019 Feb 2.

Department of Forensic Medicine, Tongji Medical College of Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, Hubei, China. Electronic address:

The diagnosis of diffuse axonal injury (DAI) is an important task in forensic pathology and clinical medicine. This study aimed to explore the use of Fourier transform infrared spectroscopy (FTIR) to detect DAI. The DAI area of the rat model was detected point by point by the FTIR-mapping system. Read More

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http://dx.doi.org/10.1016/j.legalmed.2019.02.001DOI Listing
February 2019

Atomic force microscopy-indentation demonstrates that alginate beads are mechanically stable under cell culture conditions.

J Mech Behav Biomed Mater 2019 Jan 30;93:61-69. Epub 2019 Jan 30.

Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Old Road Campus off Roosevelt Drive, OX3 7DQ, United Kingdom. Electronic address:

Alginate microbeads are extensively used in tissue engineering as microcarriers and cell encapsulation vessels. In this study, we used atomic force microscopy (AFM) based indentation using 20 µm colloidal probes to assess the local reduced elastic modulus (E * ) using a novel method to detect the contact point based on the principle of virtual work, to measure microbead mechanical stability under cell culture conditions for 2 weeks. The bead diameter and swelling were assessed in parallel. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2019.01.019DOI Listing
January 2019

Graphene oxide/titania photocatalytic ozonation of primidone in a visible LED photoreactor.

J Hazard Mater 2019 Feb 10;369:70-78. Epub 2019 Feb 10.

Departamento de Ingeniería Química y Química Física, Instituto Universitario de Investigación del Agua, Cambio Climático y Sostenibilidad, Universidad de Extremadura, 06006 Badajoz, Spain. Electronic address:

A graphene oxide-titania (GO/TiO) composite was synthesized via sol-gel method, and studied in aqueous Primidone mineralization with ozone and LED visible light. The photocatalyst was characterized by different techniques (XRD, TEM, SBET, TGA, UV-vis diffuse reflectance spectroscopy). The band gap value decrease from 3. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2019.02.025DOI Listing
February 2019

Safety and Feasibility of Robotic Distal Gastrectomy for Stage IA Gastric Cancer: A Phase II Trial.

J Surg Res 2019 Feb 14;238:224-231. Epub 2019 Feb 14.

Department of Surgery, Kitasato University School of Medicine, Sagamihara, Japan; Division of Advanced Surgical Oncology, Research and Development Center for New Medical Frontiers, Kitasato University School of Medicine, Sagamihara, Japan.

Background: Conventional laparoscopic and open distal gastrectomy procedures have inherent limitations such as restricted movement of straight forceps and tremor of the tip of the devices that can potentially be overcome using robotic distal gastrectomy (RDG). This single-institutional phase II trial aimed to evaluate the safety and feasibility of RDG with lymph node dissection for clinical stage IA gastric cancer.

Methods: The study included patients with clinical stage IA gastric cancer in the lower two-thirds of the stomach considered to be curatively resected via distal gastrectomy. Read More

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http://dx.doi.org/10.1016/j.jss.2019.01.049DOI Listing
February 2019

Multiple-correlation similarity for block-matching based fast CT to ultrasound registration in liver interventions.

Med Image Anal 2019 Feb 7;53:132-141. Epub 2019 Feb 7.

Biomedical Imaging Group Rotterdam, Departments of Radiology & Nuclear Medicine and Medical Informatics, Erasmus MC - University Medical Center Rotterdam, The Netherlands. Electronic address:

In this work we present a fast approach to perform registration of computed tomography to ultrasound volumes for image guided intervention applications. The method is based on a combination of block-matching and outlier rejection. The block-matching uses a correlation based multimodal similarity metric, where the intensity and the gradient of the computed tomography images along with the ultrasound volumes are the input images to find correspondences between blocks in the computed tomography and the ultrasound volumes. Read More

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http://dx.doi.org/10.1016/j.media.2019.02.003DOI Listing
February 2019

Single-trial estimation of quasi-static EMG-to-joint-mechanical-impedance relationship over a range of joint torques.

J Electromyogr Kinesiol 2019 Feb 8;45:18-25. Epub 2019 Feb 8.

Department of Electrical and Computer Engineering, Worcester Polytechnic Institute, Worcester, MA 01609, USA. Electronic address:

Joint mechanical impedance is commonly measured by applying dynamic perturbations about a joint at a fixed operating point/background torque, and quantifying torque change vs. angle change. Impedance characterization in functional tasks, therefore, requires multiple experimental trials over a range of operating points-a cumbersome, invasive, time-consuming and impractical task. Read More

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http://dx.doi.org/10.1016/j.jelekin.2019.02.001DOI Listing
February 2019

α-methylation and α-fluorination electronic effects on the regioselectivity of carbonyl groups of uracil by H and triel bonds in the interaction of U, T and 5FU with HCl and TrH (Tr = B, Al).

J Mol Graph Model 2019 Feb 10;88:237-246. Epub 2019 Feb 10.

Department of Chemistry, University of Kinshasa, Kinshasa XI, Democratic Republic of the Congo.

Quantum chemical calculations at the ωB97XD/6-311++G(d,p) level of theory have been executed to investigate the effect of substituents via hydrogen-bonded and triel-bonded complexes between uracil (U), thymine (T) and 5-fluorouracil (5FU) with HCl for the former complexes, and with BH and AlH for the latter complexes. These calculations are supported by single-point energy calculations at MP2/6-311++G(d,p) and CCSD/6-31 + G(d,p) levels of theory, Natural Bond Orbital (NBO) and Molecular Electrostatic Potentials (MEPs) analyses, and global/local reactivity descriptors. The results reveal that triel-bonded complexes are strongly bounded than hydrogen-bonded ones, and Al-containing dimers stronger than B-containing ones. Read More

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http://dx.doi.org/10.1016/j.jmgm.2019.02.006DOI Listing
February 2019

Quantifying correlations between mutational sites in the catalytic subunit of γ-secretase.

J Mol Graph Model 2019 Feb 8;88:221-227. Epub 2019 Feb 8.

Facultad de Química, Departamento de Fisicoquímica, Universidad Nacional Autónoma de México, CDMX, México, 04510, Mexico. Electronic address:

Presenilin 1 (PS1) is the catalytic subunit of the γ-secretase complex which is involved in the generation of amyloid-β peptides (Aβ). Single point mutations in PS1 alter the cleavage pattern of the amyloid precursor protein (APP) and lead to the formation of aberrant Aβ peptides. To date, more than two hundred mutations distributed among almost a third of PS1's amino acids have been associated to the development of Alzheimer's disease (AD). Read More

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http://dx.doi.org/10.1016/j.jmgm.2019.02.002DOI Listing
February 2019

Biodiesel production through algal cultivation in urban wastewater using algal floway.

Bioresour Technol 2019 Feb 6;280:222-228. Epub 2019 Feb 6.

Diatom Research Laboratory, Amity Institute of Biotechnology, Amity University, Noida, Uttar Pradesh 201 313, India. Electronic address:

The aim of this work was to study algal floway (AFW) to treat urban wastewater and to evaluate biomass productivity, lipid contents and biodiesel production. The results indicated the seasonal average algae productivity of 34.83 g dry weight m d with a nutrient removal rate of 2. Read More

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http://dx.doi.org/10.1016/j.biortech.2019.02.031DOI Listing
February 2019

Inactivation of dried spores of Bacillus subtilis 168 by a treatment combining high temperature and pressure.

Int J Food Microbiol 2019 Jan 30;295:1-7. Epub 2019 Jan 30.

UMR Procédés Alimentaires et Microbiologiques (équipe PMB), AgroSup Dijon, Université de Bourgogne Franche-Comté, 1, Esplanade Erasme, 21000 Dijon, France. Electronic address:

Specific treatments combining high temperatures of up to 150 °C and moderate pressure of up to 0.6 MPa have been applied to Bacillus subtilis 168 spores conditioned at different a levels (between 0.10 and 0. Read More

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http://dx.doi.org/10.1016/j.ijfoodmicro.2019.01.017DOI Listing
January 2019

Unmasking the identity of toxigenic cyanobacteria driving a multi-toxin bloom by high-throughput sequencing of cyanotoxins genes and 16S rRNA metabarcoding.

Sci Total Environ 2019 Feb 6;665:367-378. Epub 2019 Feb 6.

Departamento de Biología, C/Darwin, 2, Universidad Autónoma de Madrid, ES-28049 Madrid, Spain. Electronic address:

Cyanobacterial harmful algal blooms (CyanoHABs) are complex communities that include coexisting toxic and non-toxic strains only distinguishable by genetic methods. This study shows a water-management oriented use of next generation sequencing (NGS) to specifically pinpoint toxigenic cyanobacteria within a bloom simultaneously containing three of the most widespread cyanotoxins (the hepatotoxins microcystins, MCs; and the neurotoxins anatoxin-a, ATX, and saxitoxins, STXs). The 2013 summer bloom in Rosarito reservoir (Spain) comprised 33 cyanobacterial OTUs based on 16S rRNA metabarcoding, 7 of which accounted for as much as 96. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.083DOI Listing
February 2019

Using old cartography for the inventory of a forgotten heritage: The hydraulic heritage of the Community of Madrid.

Sci Total Environ 2019 Feb 10;665:314-328. Epub 2019 Feb 10.

IMDEA Water Institute, Avda. Punto Com 2, 28805 Alcalá de Henares, Spain; CIDE CSIC UV GV, Landscape Chem & Environm Forens Grp, Carretera Moncada, km 4-5, 46113, Valencia, Spain. Electronic address:

Hydraulic heritage is a legacy that has generally been forgotten in territorial management and protective actions. This heritage expresses the way in which inhabitants have used their water resources and related structures for centuries. For proper management, it is necessary to draw up an inventory. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.133DOI Listing
February 2019

Microbial metabolic strategies for overcoming low-oxygen in naturalized freshwater reservoirs surrounding the Athabasca Oil Sands: A proxy for End-Pit Lakes?

Sci Total Environ 2019 Feb 8;665:113-124. Epub 2019 Feb 8.

Great Lakes Institute for Environmental Research, 401 Sunset Ave, University of Windsor, Windsor, Ontario N9B 3P4, Canada.

The success and sustainability of aquatic ecosystems are driven by the complex, cooperative metabolism of microbes. Ecological engineering strategies often strive to harness this syntrophic synergy of microbial metabolism for the reclamation of contaminated environments worldwide. Currently, there is a significant knowledge gap in our understanding of how the natural microbial ecology overcomes thermodynamic limitations in recovering contaminated environments. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.032DOI Listing
February 2019

Curation and bioinformatic analysis of strabismus genes supports functional heterogeneity and proposes candidate genes with connections to RASopathies.

Gene 2019 Feb 14. Epub 2019 Feb 14.

Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, University of British Columbia, 950 West 28th Avenue, Vancouver, BC V5Z 4H4, Canada; Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada. Electronic address:

Strabismus refers to the misalignment of the eyes and occurs in 2-4% of individuals. The low-resolution label "strabismus" covers a range of heterogeneous defects, which makes it challenging to unravel this condition. Consequently a coherent understanding of the causes is lacking. Read More

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http://dx.doi.org/10.1016/j.gene.2019.02.020DOI Listing
February 2019

Association between MRI findings and back pain after osteoporotic vertebral fractures: a multicenter prospective cohort study.

Spine J 2019 Feb 14. Epub 2019 Feb 14.

Department of Orthopaedic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.

Background Context: Osteoprotic vertebral fractures(OFV) are common in elderly people. The association between back pain due to OVF with MRI signal change is unclear. In this study we hypothesized that MRI findingswould be a predictive factor for back pain measured by VAS at 6 months follow-up. Read More

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http://dx.doi.org/10.1016/j.spinee.2019.02.007DOI Listing
February 2019

Clinical Risk Factors Associated with Multidrug-Resistant Tuberculosis (MDR-TB) in Mali.

Int J Infect Dis 2019 Feb 14. Epub 2019 Feb 14.

University Clinical Research Center (UCRC)- SEREFO Laboratory, University of Sciences, Techniques and Technologies of Bamako (USTTB), Bamako, Mali. Electronic address:

Background: MDR-TB is a major threat to global TB control. In 2015, 580,000 were treated for MDR-TB worldwide. The worldwide roll-out of GeneXpert MTB/RIF has improved diagnosis of MDR-TB; however, in many countries laboratories are unable to assess drug resistance and clinical predictors of MDR-TB could help target suspected patients. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.02.004DOI Listing
February 2019

Predicting Survival in Patients with Pulmonary Arterial Hypertension: The REVEAL Risk Score Calculator 2.0 and Comparison with ESC/ERS-Based Risk Assessment Strategies.

Chest 2019 Feb 14. Epub 2019 Feb 14.

Mayo Clinic, Rochester, MN, USA.

Background: Pulmonary arterial hypertension is a progressive, fatal disease. Published treatment guidelines recommend treatment escalation based on regular patient assessment with the goal of achieving or maintaining low-risk status. Various strategies are available to determine risk status. Read More

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http://dx.doi.org/10.1016/j.chest.2019.02.004DOI Listing
February 2019

Recombinant protein purification in baculovirus-infected rachiplusia nu larvae: An approach towards a rational design of downstream processing strategies based on chromatographic behavior of proteins.

Protein Expr Purif 2019 Feb 14. Epub 2019 Feb 14.

Facultad de Farmacia y Bioquímica, Cátedra de Biotecnología, Universidad de Buenos Aires, Junín 956, 1113, Buenos Aires, Argentina; Instituto de Nanobiotecnología (NANOBIOTEC), CONICET-Universidad de Buenos Aires, Junín 956, 1113, Buenos Aires, Argentina. Electronic address:

Expression of recombinant proteins with baculovirus-infected insect larvae is a scarcely investigated alternative in comparison to that in insect cell lines, a system with growing popularity in the field of biotechnology. The aim of this study was to investigate the chromatographic behavior and physicochemical properties of the proteome of Rachiplusia nu larvae infected with recombinant Autographa californica multiple nucleopolyhedrosis virus (AcMNPV), in order to design rational purification strategies for the expression of heterologous proteins in this very complex and little-known system, based on the differential absorption between target recombinant proteins and the system's contaminating ones. Two-dimensional (2D) gel electrophoresis showed differences in the protein patterns of infected and non-infected larvae. Read More

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http://dx.doi.org/10.1016/j.pep.2019.02.009DOI Listing
February 2019

Essential Research Priorities in Renal Cancer: A Modified Delphi Consensus Statement.

Eur Urol Focus 2019 Feb 13. Epub 2019 Feb 13.

Department of Surgery, University of Cambridge, Addenbrooke's Hospital, Cambridge Biomedical Campus, Cambridge, UK. Electronic address:

Background: Identification of clear and focused research priorities is crucial to drive research forward.

Objective: To identify research priorities in renal cell carcinoma (RCC) through a multidisciplinary collaboration between clinicians, researchers, and patients.

Design, Setting, And Participants: In phase I, 44 RCC experts provided 24 literature reviews within their field, summarising research gaps (RGs). Read More

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http://dx.doi.org/10.1016/j.euf.2019.01.014DOI Listing
February 2019

Total Mandibular subapical osteotomy to correct Class II with inferior alveolar retrusion.

Int Orthod 2019 Feb 13. Epub 2019 Feb 13.

Service de chirurgie maxillofaciale et stomatologie, hôpital Roger-Salengro, centre hospitalier régional universitaire de Lille, avenue du Professeur-Emile-Laine, 59000 Lille, France.

Purpose: Class II dento-facial deformity due to inferior alveolar retrusion may be difficult to treat using conventional surgical procedures. The aim of this study was to report on total mandibular subapical osteotomy (TMSO) to correct inferior alveolar retrusion, to describe its indications, the surgical technique and to analyse the aesthetic, occlusal changes and stability.

Materials And Methods: Patients treated with TMSO from January 2004 to December 2014 were included and analysed retrospectively. Read More

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http://dx.doi.org/10.1016/j.ortho.2019.01.011DOI Listing
February 2019

Brillouin Spectroscopy of Normal and Keratoconus Corneas.

Am J Ophthalmol 2019 Feb 14. Epub 2019 Feb 14.

Wellman Center for Photomedicine - Massachusetts General Hospital, Harvard Medical School, Boston, MA.

Purpose: To investigate the age-dependence of Brillouin spectroscopy of the cornea and to compare normal and keratoconus corneas.

Design: Retrospective case-control study STUDY POPULATION: Healthy patients and patients suffering from keratoconus seen at the Institut für Refraktive und Ophthalmo-Chirurgie (IROC) between December 2016 and March 2017.

Methods: Brillouin frequency shifts of patients of 2 different groups were examined with Brillouin spectroscopy perpendicular to the corneal surface. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.02.010DOI Listing
February 2019

Experiences with the daily use of medications among chronic hepatitis C patients.

Res Social Adm Pharm 2019 Feb 1. Epub 2019 Feb 1.

College of Pharmacy, Center for Pharmaceutical Care Studies, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.

Background: Subjective experiences with medication use are individual experiences that can impact health outcomes by contributing to problems related to such use.

Objetives: The aim of the present study was to understand the experiences of chronic hepatitis C patients who were taking chronic medications, based on the phenomenology proposed by Merleau-Ponty and connection among this experience with the essential structures of the experience.

Methods: Data were gathered from interviews conducted with ten individuals taking long-term medications at the Viral Hepatitis Outpatient Clinic of the Alfa Gastroenterology Institute of the Hospital das Clínicas, Federal University of Minas Gerais, Brazil. Read More

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http://dx.doi.org/10.1016/j.sapharm.2019.01.018DOI Listing
February 2019

Assessment of dose to functional sub-structures in the lower urinary tract in locally advanced cervical cancer radiotherapy.

Phys Med 2019 Feb 13. Epub 2019 Feb 13.

Department of Oncology, Aarhus University Hospital, Nørrebrogade 44, 8000 Aarhus C, Denmark.

Purpose: To provide an analysis of dose distribution in sub-structures that could be responsible for urinary toxicity after Image-Guided Adaptive BrachyTherapy (IGABT) in Locally Advanced Cervical Cancer (LACC).

Methods: 105 LACC patients treated with radiochemotherapy and IGABT were selected. Sub-structures (bladder wall, trigone, bladder neck, urethra) were contoured on IGABT-planning MRIs. Read More

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http://dx.doi.org/10.1016/j.ejmp.2019.01.017DOI Listing
February 2019

An fluorescent aptasensor for sensitive detection of tumor marker based on the FRET of a sandwich structured QDs-AFP-AuNPs.

Talanta 2019 May 3;197:444-450. Epub 2019 Jan 3.

State Key Laboratory for Diagnosis and Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang, China. Electronic address:

The detection of alpha-fetoprotein (AFP) is of great importance for hepatocellular carcinoma (HCC) diagnosis, but it needs to be further improved because of poor sensitivity and complicated operating steps. In this paper, a simple and sensitive homogeneous apatasensor for AFP has been developed based on Förster resonance energy transfer (FRET) where the AFP aptamer labeled luminescent CdTe quantum dots (QDs) as a donor and anti-AFP antibody functional gold nanoparticles (AuNPs) as an acceptor. In the presence of AFP, the bio-affinity between aptamer, target, and antibody made the QDs and AuNPs close enough, thus the fluorescence of CdTe QDs quenched though the FRET between QD and AuNP. Read More

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http://dx.doi.org/10.1016/j.talanta.2019.01.012DOI Listing

Peak bordering for ultrafast single particle analysis using ICP-MS.

Talanta 2019 May 8;197:189-198. Epub 2019 Jan 8.

University of Chemistry and Technology Prague, Technická 5, 166 28 Prague 6, Czech Republic.

The characterisation of inorganic nanoparticles (NPs) by single particle inductively coupled plasma mass spectroscopy is possible only if the spectrometer is capable of measurement with high time-signal resolution. The latest generation of spectrometers allow for measurements with dwell times (dt) shorter than the 100 μs gold standard, i.e. Read More

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http://dx.doi.org/10.1016/j.talanta.2019.01.030DOI Listing

Role of Abdominal US in Diagnosis of NEC.

Authors:
Jae H Kim

Clin Perinatol 2019 Mar 20;46(1):119-127. Epub 2018 Dec 20.

SPIN Program, San Diego Mothers' Milk Bank, Division of Neonatology, UC San Diego, 9300 Campus Point Drive MC7774, La Jolla, CA 92037, USA; Division of Pediatric Gastroenterology, Hepatology and Nutrition, Rady Children's Hospital-San Diego, 3020 Children's Way, San Diego, CA 92123. Electronic address:

Current assessment for and diagnosis of necrotizing enterocolitis (NEC) remain inadequate. The introduction of interrogating bowel with ultrasound when NEC is suspected or when NEC has occurred presents greater opportunity to characterize the physical changes that have occurred in the bowel wall structures. The evaluation of bowel by ultrasound has been shown to have high specificity for bowel necrosis. Read More

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http://dx.doi.org/10.1016/j.clp.2018.10.006DOI Listing

Biomarker Discovery and Utility in Necrotizing Enterocolitis.

Clin Perinatol 2019 Mar 12;46(1):1-17. Epub 2018 Dec 12.

Department of Surgery, Division of Pediatric Surgery, 300 Pasteur Drive, Alway Building M116, MC 5733, Stanford, CA 94305. Electronic address:

Necrotizing enterocolitis (NEC) is a devastating disease of prematurity, with no current method for early diagnosis. Diagnosis is particularly challenging, frequently occurring after the disease has progressed to the point of significant and often irreversible intestinal damage. Biomarker research has tremendous potential to advance clinical management of NEC and our understanding of its pathogenesis. Read More

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http://dx.doi.org/10.1016/j.clp.2018.10.001DOI Listing

Neurological recovery following traumatic spinal cord injury: a systematic review and meta-analysis.

J Neurosurg Spine 2019 Feb 15:1-17. Epub 2019 Feb 15.

1Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences.

OBJECTIVEPredicting neurological recovery following traumatic spinal cord injury (TSCI) is a complex task considering the heterogeneous nature of injury and the inconsistency of individual studies. This study aims to summarize the current evidence on neurological recovery following TSCI by use of a meta-analytical approach, and to identify injury, treatment, and study variables with prognostic significance.METHODSA literature search in MEDLINE and EMBASE was performed, and studies reporting follow-up changes in American Spinal Injury Association (ASIA) Impairment Scale (AIS) or Frankel or ASIA motor score (AMS) scales were included in the meta-analysis. Read More

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http://dx.doi.org/10.3171/2018.10.SPINE18802DOI Listing
February 2019

Locating the foramen ovale by using molar and inter-eminence planes: a guide for percutaneous trigeminal neuralgia procedures.

J Neurosurg 2019 Feb 15:1-7. Epub 2019 Feb 15.

Departments of1Natural Sciences and Mathematics and.

OBJECTIVEThe first attempt to cannulate the foramen ovale is oftentimes unsuccessful and requires subsequent reattempts, thereby increasing the risk of an adverse event and radiation exposure to the patient and surgeon. Failure in cannulation may be attributable to variation in soft-tissue-based landmarks used for needle guidance. Also, the incongruity between guiding marks on the face and bony landmarks visible on fluoroscopic images may also complicate cannulation. Read More

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http://dx.doi.org/10.3171/2018.11.JNS182276DOI Listing
February 2019

Rear Admiral (Astronaut) Alan Shepard: Ménière's disease and the race to the moon.

J Neurosurg 2019 Feb 15:1-7. Epub 2019 Feb 15.

6Department of Neurosurgery, University of South Alabama, Mobile, Alabama.

On May 5, 1961, Alan B. Shepard Jr. piloted the Freedom 7 craft into a suborbital flight to become the first American man in space. Read More

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http://dx.doi.org/10.3171/2018.9.JNS182522DOI Listing
February 2019

Validation of source detective system of the radionuclides measured in the atmosphere using a field tracer experiment.

Environ Pollut 2019 Feb 7;248:10-17. Epub 2019 Feb 7.

Environmental Safety Research Division, Korea Atomic Energy Research Institute, Daedeok-daero 989-111, Yuseong-gu, Daejeon, 305-353, Republic of Korea.

A source detective system has been developed to estimate unknown source regions and release rates of radionuclides released into the air from covert nuclear activities and accidents. This system is composed of trajectory, atmospheric dispersion, and source term estimation models. Simulated results were compared with the measurements of a field tracer experiment performed at the Yeonggwang nuclear power plant in Korea in May 1996. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.01.121DOI Listing
February 2019

MnO nanosheets as the biomimetic oxidase for rapid and sensitive oxalate detection combining with bionic E-eye.

Biosens Bioelectron 2019 Jan 21;130:254-261. Epub 2019 Jan 21.

Biosensor National Special Laboratory, Key Laboratory of Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China; State Key Laboratory of Transducer Technology, Chinese Academy of Sciences, Shanghai 200050, China. Electronic address:

Urolithiasis commonly occurs in kidney and ureteral, and may cause local organ/tissue damage, even kidney failure. The incidence of this disease is increasing worldwide, in which calcium oxalate is the major composition forming the urinary calculus. Therefore, to monitor this disease for the prevention and treatment, measuring the oxalate in the urine is of great significance. Read More

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http://dx.doi.org/10.1016/j.bios.2019.01.026DOI Listing
January 2019
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Data fitting approach more critical than exposure scenarios and treatment of censored data for quantitative microbial risk assessment.

Water Res 2019 Feb 4;154:45-53. Epub 2019 Feb 4.

Instituto de Investigaciones para la Industria Química (INIQUI), CONICET, Universidad Nacional de Salta (UNSa), Av. Bolivia 5150, Salta, 4400, Argentina; Singapore Centre for Environmental Life Sciences Engineering (SCELSE), Nanyang Technological University, 637551, Singapore; Facultad de Ingeniería, UNSa, Salta, Argentina. Electronic address:

Recreational waters are a source of many diseases caused by human viral pathogens, including norovirus genogroup II (NoV GII) and enterovirus (EV). Water samples from the Arenales river in Salta, Argentina, were concentrated by ultrafiltration and analyzed for the concentrations of NoV GII and EV by quantitative PCR. Out of 65 samples, 61 and 59 were non-detects (below the Sample Limit of Detection limit, SLOD) for EV and NoV GII, respectively. Read More

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http://dx.doi.org/10.1016/j.watres.2019.01.041DOI Listing
February 2019

Maladaptive nest-site selection by a sagebrush dependent species in a grazing-modified landscape.

J Environ Manage 2019 Feb 13;236:622-630. Epub 2019 Feb 13.

Department of Animal and Range Sciences, Montana State University, Animal Bioscience Building 205, Bozeman, MT 59717, USA.

Animals are expected to select habitats that maximize their fitness over evolutionary time scales. Yet in human-modified landscapes, habitat selection might not always lead to increased fitness because animals undervalue high-quality resources that appear less attractive than those of lower quality. In the American West, agriculture has modified landscapes, yet little is known about whether agricultural changes alter the reliability of the cues animals use to identify habitat quality; ultimately forming maladaptive breeding strategies where behavioral cues are mismatched with survival outcomes. Read More

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http://dx.doi.org/10.1016/j.jenvman.2019.01.085DOI Listing
February 2019

Application of integrative cloud point extraction and concentration for the analysis of polyphenols and alkaloids in mulberry leaves.

J Pharm Biomed Anal 2019 Feb 10;167:132-139. Epub 2019 Feb 10.

Northeast Forestry University, Hexing Road 26, 150040, Harbin, PR China. Electronic address:

A simple and efficient method based on cloud point extraction and concentration combined with high performance liquid chromatography was developed for the simultaneous separation and determination of five target compounds (deoxynojirimycin, chlorogenic acid, rutin, isoquercitrin and astragalin) in mulberry leaves samples. Firstly, to obtain a high extraction rate, the ultrasound assisted extraction was developed on acid modified Triton X-114 system. Under the optimal conditions, the total maximum extraction yields of five target compounds reached 20. Read More

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http://dx.doi.org/10.1016/j.jpba.2019.02.002DOI Listing
February 2019

Utility of Likert scale (Deauville criteria) in assessment of Chemoradiotherapy response of primary oropharyngeal squamous cell Cancer site.

Clin Imaging 2019 Jan 16;55:89-94. Epub 2019 Jan 16.

Department of Radiology, Division of Nuclear Medicine, University of Minnesota Medical Center, Minneapolis, MN, USA. Electronic address:

Introduction: The aim of this study is to determine whether Likert scale (Deauville criteria) can be used to classify oropharyngeal squamous cell cancer (OPSCC) patients as 'responders' and 'nonresponders' by utilizing FDG-PET/CT for primary tumor site. The second aim is to compare the performance of methods used in interpretation of posttreatment PET/CT scans (Likert scale, SUVmax, ratios of SUVmax primary lesion to mediastinum 'SUVmax P/M' and SUVmax primary lesion to liver 'SUVmax P/L') in predicting treatment response.

Methods: Seventy-seven PET/CT scans were assessed by Deauville criteria, five-point Likert scale. Read More

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http://dx.doi.org/10.1016/j.clinimag.2019.01.007DOI Listing
January 2019

Narratives in student nurses' knowledge development: A hermeneutical research study.

Authors:
Johanne Alteren

Nurse Educ Today 2019 Feb 6;76:51-55. Epub 2019 Feb 6.

Nord University, Faculty of Nursing and Health Science, Mo I Rana, Norway. Electronic address:

Background: Knowledge development, and how student nurses learn to be nurses, is essential in nurse education and has implications for quality of care. There is a lack of research concerning how student nurses' knowledge development is expressed through narratives and how they deal with challenges in patient situations in professional learning.

Objectives: To clarify the usefulness of narratives in student nurses' knowledge development and the narratives implications for learning in clinical training. Read More

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http://dx.doi.org/10.1016/j.nedt.2019.01.015DOI Listing
February 2019
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H NMR metabolomic analysis of skin and blubber of bottlenose dolphins reveal a functional metabolic dichotomy.

Comp Biochem Physiol Part D Genomics Proteomics 2019 Feb 10;30:25-32. Epub 2019 Feb 10.

Departamento de Recursos del Mar, Cinvestav Unidad Mérida, Mérida, Yucatán 97310, Mexico; CONACYT, Mexico. Electronic address:

The common bottlenose dolphin (Tursiops truncatus) is a carnivorous cetacean thriving in marine environment that is one of the apex predators of the marine food web. They are found in coastal and estuarine ecosystems which are known to be sensitive to environmental impacts. Dolphins are considered sentinel organisms for monitoring the health of coastal marine ecosystems in their role as predators that can bioaccumulate contaminants. Read More

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http://dx.doi.org/10.1016/j.cbd.2019.02.004DOI Listing
February 2019

RAMS: Remote and automatic mammogram screening.

Comput Biol Med 2019 Feb 5;107:18-29. Epub 2019 Feb 5.

Quality of Life Technology Laboratory, Department of Electrical and Computer Engineering, The University of Texas at Dallas, 800 W. Campbell Road, Richardson, TX, 75080, USA. Electronic address:

About one in eight women in the U.S. will develop invasive breast cancer at some point in life. Read More

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http://dx.doi.org/10.1016/j.compbiomed.2019.01.024DOI Listing
February 2019

Bilateral extradural PICA origins at the point at which the VA ascends between the transverse foramina of C-2 and C-1, simultaneously exist right double origin PICA: a rare case report and literature review.

World Neurosurg 2019 Feb 13. Epub 2019 Feb 13.

Department of Neurosurgery, Xuanwu Hospital,Capital Medical University, Bejing ,China.

Background: The location of the origin of the PICA is highly variable. An extracranial origin PICA from the vertebral artery(VA) is not rare. But, the PICA originated extradurally at the point at which the VA ascends between the transverse foramina of C-2 and C-1 is one very rare anatomic variant. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.233DOI Listing
February 2019

Revisiting systemic treatment of bacterial endophthalmitis: a review of intravitreal penetration of systemic antibiotics.

Clin Microbiol Infect 2019 Feb 13. Epub 2019 Feb 13.

Division of Infectious Diseases and Hospital Epidemiology, Departments of Medicine and Clinical Research, University Hospital of Basel and University of Basel, Basel, Switzerland.

Background: Adjunctive systemic antibiotic therapy for treatment of bacterial endophthalmitis is controversial but common practice due to the severity of the disease. In absence of guidance documents, several antibiotic regimens are being used without applying evidence-based prescribing, thus leading to inappropriate treatment of this serious eye condition.

Objectives: To summarize available data on intravitreal penetration of systemically administered antibiotics and to discuss their usefulness from a microbiological and pharmacological point of view. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.01.017DOI Listing
February 2019

Outcomes of Long-term Interval Rescreening with Low-Dose CT for Lung Cancer in Different Risk Cohorts.

J Thorac Oncol 2019 Feb 13. Epub 2019 Feb 13.

Department of Cardiothoracic Imaging, Toronto Joint Department of Medical Imaging, University of Toronto, Toronto, Canada.

Hypothesis: We hypothesize that the incidence of screen-detected lung cancer (LC), in participants with previously negative scans, will be highest in the cohort with the highest baseline risk score.

Methods: Individuals with negative baseline screening results from the Princess Margaret International Early Lung Cancer Action Program prior to 2009 underwent low-dose CT rescreening from 2015 to 2018. Individuals were contacted in order of descending risk, as determined by the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial's PLCO 6-year LC risk-prediction model, and then categorized into three risk cohorts according to their baseline risks. Read More

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http://dx.doi.org/10.1016/j.jtho.2019.01.031DOI Listing
February 2019

Fin whale (Balaenoptera physalus) mitogenomics: A cautionary tale of defining sub-species from mitochondrial sequence monophyly.

Mol Phylogenet Evol 2019 Feb 13. Epub 2019 Feb 13.

Marine Evolution and Conservation, Groningen Institute of Evolutionary Life Sciences, University of Groningen, Nijenborgh 7, 9747 AG, Groningen, The Netherlands; Center for Coastal Studies, 5 Holway Avenue, Provincetown, MA 02657, United States of America. Electronic address:

The advent of massive parallel sequencing technologies has resulted in an increase of studies based upon complete mitochondrial genome DNA sequences that revisit the taxonomic status within and among species. Spatially distinct monophyly in such mitogenomic genealogies, i.e. Read More

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http://dx.doi.org/10.1016/j.ympev.2019.02.003DOI Listing
February 2019

Entry of therapeutics into the brain: influence of exposed polarity calculated in silico and measured in vitro by supercritical fluid chromatography.

Int J Pharm 2019 Feb 13. Epub 2019 Feb 13.

Worldwide Medicinal Chemistry, Pfizer Global Research & Development, Groton Laboratories, Eastern Point Road, Groton, Connecticut 06340, United States. Electronic address:

The present work proposes a novel application of EPSA (not an acronym but found to be referred to by many as Exposed Polar Surface Area), a supercritical fluid chromatography (SFC) polarity readout for assisting in the prediction of the extent of drug permeation through the blood-brain barrier (BBB). For this purpose, EPSA values for 69 structurally unrelated acidic, basic, neutral and amphoteric compounds were determined by a validated SFC method. Additionally, water-accessible surface area (WASA) values for the whole dataset were calculated in silico and compared to experimentally determined EPSA values. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.02.008DOI Listing
February 2019

Molecular simulation as a computational pharmaceutics tool to predict drug solubility, solubilization processes and partitioning.

Eur J Pharm Biopharm 2019 Feb 13. Epub 2019 Feb 13.

Department of Pharmacy, Uppsala Biomedical Center, Uppsala University, 751 23 Uppsala, Sweden; Swedish Drug Delivery Forum (SDDF), Uppsala University, Sweden. Electronic address:

In this review we will discuss how computational methods, and in particular classical molecular dynamics simulations, can be used to calculate solubility of pharmaceutically relevant molecules and systems. To the extent possible, we focus on the non-technical details of these calculations, and try to show also the added value of a more thorough and detailed understanding of the solubilization process obtained by using computational simulations. Although the main focus is on classical molecular dynamics simulations, we also provide the reader with some insights into other computational techniques, such as the COSMO-method, and also discuss Flory-Huggins theory and solubility parameters. Read More

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http://dx.doi.org/10.1016/j.ejpb.2019.02.007DOI Listing
February 2019

ProNGF increases breast tumor aggressiveness through functional association of TrkA with EphA2.

Cancer Lett 2019 Feb 13. Epub 2019 Feb 13.

Inserm, U908, F-59000, Lille, France; Univ. Lille, U908 - CPAC, Cell Plasticity and Cancer, F-59000, Lille, France. Electronic address:

ProNGF expression has been linked to several types of cancers including breast cancer, and we have previously shown that proNGF stimulates breast cancer invasion in an autocrine manner through membrane receptors sortilin and TrkA. However, little is known regarding TrkA-associated protein partners upon proNGF stimulation. By proteomic analysis and proximity ligation assays, we found that proNGF binding to sortilin induced sequential formation of the functional sortilin/TrkA/EphA2 complex, leading to TrkA-phosphorylation dependent Akt activation and EphA2-dependent Src activation. Read More

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http://dx.doi.org/10.1016/j.canlet.2019.02.019DOI Listing
February 2019
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