23,841 results match your criteria Pneumonia Viral


Influenza sequelae: from immune modulation to persistent alveolitis.

Clin Sci (Lond) 2020 Jul;134(13):1697-1714

Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, U.S.A.

Acute influenza virus infections are a global public health concern accounting for millions of illnesses worldwide ranging from mild to severe with, at time, severe complications. Once an individual is infected, the immune system is triggered in response to the pathogen. This immune response can be beneficial ultimately leading to the clearance of the viral infection and establishment of immune memory mechanisms. Read More

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http://dx.doi.org/10.1042/CS20200050DOI Listing

Deploying Biomolecules as Anti-COVID-19 Agents.

Indian J Microbiol 2020 Sep 9;60(3):263-268. Epub 2020 Jun 9.

Department of Chemical Engineering, Konkuk University, Seoul, 05029 Republic of Korea.

Severe acute respiratory syndrome coronavirus (SARS-CoV-2) known as COVID-19 has emerged as a major threat to human existence. COVID-19 seems to have undergone adaptive evolution through an intermediate host, most likely bats. The flu leads to severe pneumonia that causes respiratory and multi-organ failure. Read More

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http://dx.doi.org/10.1007/s12088-020-00893-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282542PMC
September 2020

Obesity, the most common comorbidity in SARS-CoV-2: is leptin the link?

Int J Obes (Lond) 2020 Jul 9. Epub 2020 Jul 9.

Pennington Biomedical Research Center, 6400, Perkins Road, Baton Rouge, LA 70808, USA.

Overweight and obesity are major risk factors for diabetes, cardiovascular disease, and lung disease. These diseases are the most commonly reported health conditions that predispose individuals with SARS-CoV-2 infection to require hospitalization including intensive care unit admissions. The innate immune response is the host's first line of defense against a human coronavirus infection. Read More

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http://dx.doi.org/10.1038/s41366-020-0640-5DOI Listing

Liver transplant immunosuppression during the covid-19 pandemic.

Gastroenterol Hepatol 2020 Jun 12. Epub 2020 Jun 12.

Unidad de Hepatitis Víricas y Unidad de Trasplante Hepático, Servicio de Hepatología, Hospital Clínic. Universitat de Barcelona, IDIBAPS, CIBERehd, Barcelona, España. Electronic address:

SARS-CoV-2 infection has produced a pandemic with serious consequences for our health care system. Although liver transplant patients represent only a minority of the population, the hepatologists who follow these patients have tried to coordinate efforts to produce a protocol the management of immunosuppression during SARS-CoV-2 infection. Although there are no solid studies to support general recommendations, experiences with other viral infections (hepatitis C, cytomegalovirus) suggest that management of immunosuppression without mycophenolate mofetil or m-Tor inhibitors (drugs that are also associated with leukopenia and lymphopenia) may be beneficial. Read More

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http://dx.doi.org/10.1016/j.gastrohep.2020.06.003DOI Listing

Baricitinib, a drug with potential effect to prevent SARS-COV-2 from entering target cells and control cytokine storm induced by COVID-19.

Int Immunopharmacol 2020 Jul 1;86:106749. Epub 2020 Jul 1.

Department of Pharmacy, Wuxi People's Hospital Attached to Nanjing Medical University, Wuxi 214023, Jiangsu, China. Electronic address:

In December 2019, a novel coronavirus pneumonia (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) suddenly broke out in China and rapidly spread all over the world. Recently, a cell surface protein, known as angiotensin-converting enzyme II (ACE2), has been identified to be involved in receptor-mediated endocytosis for SARS-CoV-2 entry to the cells. Many studies have reported the clinical characteristics of COVID-19: sudden deterioration of disease around 1-2 weeks after onset; much lower level of lymphocytes, especially natural killer (NK) cells in peripheral blood; extremely high pro-inflammatory cytokines and C reactive protein (CRP). Read More

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http://dx.doi.org/10.1016/j.intimp.2020.106749DOI Listing

Angiotensin II Receptors - Impact for COVID-19 Severity.

Dermatol Ther 2020 Jul 9:e13989. Epub 2020 Jul 9.

Department of Dermatology and Allergology, Städtisches Klinikum Dresden, Academic Teaching Hospital of the Technical University, Dresden, Germany.

COVID-19 is an outbreak of viral pneumonia which became a global health crisis, and the risk of morbidity and mortality of people with obesity are higher. SARS-CoV-2, the pathogen of COVID-19, enters into cells through binding to the Angiotensin Converting Enzyme (ACE) homolog-2 (ACE2). ACE2 is a regulator of two contrary pathways in renin angiotensin system (RAS): ACE-Ang-II-AT1R axis and ACE2-Ang 1-7-Mas axis. Read More

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http://dx.doi.org/10.1111/dth.13989DOI Listing

CT in relation to RT-PCR in diagnosing COVID-19 in The Netherlands: A prospective study.

PLoS One 2020 9;15(7):e0235844. Epub 2020 Jul 9.

Department of Internal Medicine, Division of General Internal Medicine, Section Acute Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands.

Introduction: Early differentiation between emergency department (ED) patients with and without corona virus disease (COVID-19) is very important. Chest CT scan may be helpful in early diagnosing of COVID-19. We investigated the diagnostic accuracy of CT using RT-PCR for SARS-CoV-2 as reference standard and investigated reasons for discordant results between the two tests. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235844PLOS

Update: COVID-19 Among Workers in Meat and Poultry Processing Facilities - United States, April-May 2020.

MMWR Morb Mortal Wkly Rep 2020 Jul 10;69(27):887-892. Epub 2020 Jul 10.

Meat and poultry processing facilities face distinctive challenges in the control of infectious diseases, including coronavirus disease 2019 (COVID-19) (1). COVID-19 outbreaks among meat and poultry processing facility workers can rapidly affect large numbers of persons. Assessment of COVID-19 cases among workers in 115 meat and poultry processing facilities through April 27, 2020, documented 4,913 cases and 20 deaths reported by 19 states (1). Read More

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http://dx.doi.org/10.15585/mmwr.mm6927e2DOI Listing

Initial and Repeated Point Prevalence Surveys to Inform SARS-CoV-2 Infection Prevention in 26 Skilled Nursing Facilities - Detroit, Michigan, March-May 2020.

MMWR Morb Mortal Wkly Rep 2020 Jul 10;69(27):882-886. Epub 2020 Jul 10.

Skilled nursing facilities (SNFs) are focal points of the coronavirus disease 2019 (COVID-19) pandemic, and asymptomatic infections with SARS-CoV-2, the virus that causes COVID-19, among SNF residents and health care personnel have been described (1-3). Repeated point prevalence surveys (serial testing of all residents and health care personnel at a health care facility irrespective of symptoms) have been used to identify asymptomatic infections and have reduced SARS-CoV-2 transmission during SNF outbreaks (1,3). During March 2020, the Detroit Health Department and area hospitals detected a sharp increase in COVID-19 diagnoses, hospitalizations, and associated deaths among SNF residents. Read More

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http://dx.doi.org/10.15585/mmwr.mm6927e1DOI Listing

Race/Ethnicity, Underlying Medical Conditions, Homelessness, and Hospitalization Status of Adult Patients with COVID-19 at an Urban Safety-Net Medical Center - Boston, Massachusetts, 2020.

MMWR Morb Mortal Wkly Rep 2020 Jul 10;69(27):864-869. Epub 2020 Jul 10.

As of July 5, 2020, approximately 2.8 million coronavirus disease 2019 (COVID-19) cases and 130,000 COVID-19-associated deaths had been reported in the United States (1). Populations historically affected by health disparities, including certain racial and ethnic minority populations, have been disproportionally affected by and hospitalized with COVID-19 (2-4). Read More

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http://dx.doi.org/10.15585/mmwr.mm6927a3DOI Listing

Provision of Pediatric Immunization Services During the COVID-19 Pandemic: an Assessment of Capacity Among Pediatric Immunization Providers Participating in the Vaccines for Children Program - United States, May 2020.

MMWR Morb Mortal Wkly Rep 2020 Jul 10;69(27):859-863. Epub 2020 Jul 10.

CDC COVID-19 Emergency Response Team.

Recent reports suggest that routine childhood immunization coverage might have decreased during the coronavirus disease 2019 (COVID-19) pandemic (1,2). To assess the capacity of pediatric health care practices to provide immunization services to children during the pandemic, a survey of practices participating in the Vaccines for Children (VFC) program was conducted during May 12-20, 2020. Data were weighted to account for the sampling design; thus, all percentages reported are weighted. Read More

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http://dx.doi.org/10.15585/mmwr.mm6927a2DOI Listing

Increases in Health-Related Workplace Absenteeism Among Workers in Essential Critical Infrastructure Occupations During the COVID-19 Pandemic - United States, March-April 2020.

MMWR Morb Mortal Wkly Rep 2020 Jul 10;69(27):853-858. Epub 2020 Jul 10.

During a pandemic, syndromic methods for monitoring illness outside of health care settings, such as tracking absenteeism trends in schools and workplaces, can be useful adjuncts to conventional disease reporting (1,2). Each month, CDC's National Institute for Occupational Safety and Health (NIOSH) monitors the prevalence of health-related workplace absenteeism among currently employed full-time workers in the United States, overall and by demographic and occupational subgroups, using data from the Current Population Survey (CPS).* This report describes trends in absenteeism during October 2019-April 2020, including March and April 2020, the period of rapidly accelerating transmission of SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19). Read More

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http://dx.doi.org/10.15585/mmwr.mm6927a1DOI Listing

Primer design for quantitative real-time PCR for the emerging Coronavirus SARS-CoV-2.

Theranostics 2020 1;10(16):7150-7162. Epub 2020 Jun 1.

National Center for Clinical Laboratories, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.

In December 2019, a new coronavirus disease (COVID-19) outbreak occurred in Wuhan, China. Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), which is the seventh coronavirus known to infect humans, is highly contagious and has rapidly expanded worldwide since its discovery. Quantitative nucleic acid testing has become the gold standard for diagnosis and guiding clinical decisions regarding the use of antiviral therapy. Read More

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http://dx.doi.org/10.7150/thno.47649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330846PMC

Use of Procalcitonin for Identification of Cobacterial Pneumonia in Pediatric Patients.

J Pediatr Pharmacol Ther 2020 ;25(5):445-450

Objective: To evaluate the utility of procalcitonin (PCT) in identifying cobacterial pneumonia in pediatric patients with known viral respiratory infection.

Methods: A retrospective cohort study was conducted in a stand-alone children's hospital during 2 time periods (period 1: October 1, 2014, to March 31, 2015; period 2: October 1, 2015, to March 31, 2016). Patients admitted with any upper respiratory tract infection were included. Read More

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http://dx.doi.org/10.5863/1551-6776-25.5.445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337135PMC
January 2020

Inflammation, Immunity and Immunogenetics in COVID-19: A Narrative Review.

Indian J Clin Biochem 2020 Jul 6;35(3):260-273. Epub 2020 Jun 6.

Department of Biochemistry, All India Institute of Medical Sciences Jodhpur, Jodhpur, India.

The novel Coronavirus Disease 2019 (COVID-19), that began in Wuhan Province, China was labelled as an International Public Health Emergency on January 30, 2020 and later was declared a pandemic by the World Health Organisation (WHO) on March 11, 2020. The causative agent, SARS-CoV-2 was the third coronavirus responsible for causing major disease outbreaks in human population after Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) caused by SARS-CoV and MERS-CoV respectively. The patients of COVID-19 present with a clinical feature resembling mild form of viral pneumonia which in certain cases progress to a severe form characterised by adult respiratory distress syndrome (ARDS) and/or multiorgan failure leading to death. Read More

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http://dx.doi.org/10.1007/s12291-020-00897-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275846PMC

Serpentoviruses, more than respiratory pathogens.

J Virol 2020 Jul 8. Epub 2020 Jul 8.

Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zürich, Zürich, Switzerland

In recent years nidoviruses have emerged as important respiratory pathogens of reptiles, affecting captive python populations. In pythons, nidovirus (recently reclassified as serpentovirus) infection induces an inflammation of the upper respiratory and alimentary tract which can develop into a severe, often fatal proliferative pneumonia. We observed pyogranulomatous and fibrinonecrotic lesions in organ systems other than the respiratory tract during full post mortem examinations on 30 serpentovirus RT-PCR positive pythons of varying species originating from Switzerland and Spain. Read More

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http://dx.doi.org/10.1128/JVI.00649-20DOI Listing

BTK/ITK dual inhibitors: Modulating immunopathology and lymphopenia for COVID-19 therapy.

J Leukoc Biol 2020 Jul 8. Epub 2020 Jul 8.

Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana, USA.

Bruton's tyrosine kinase (BTK) signaling is involved in innate immune responses and regulates the production of proinflammatory cytokines that can contribute to COVID-19 immunopathology. Clinical trials with BTK inhibitors in COVID-19 treatment have been proposed, and previous studies have attempted to investigate the therapeutic effects of ibrutinib and underlying mechanisms in treating viral pneumonia. These attempts, however, did not consider potential off target effect of BTK inhibitors on T cell differentiation, function, and survival, which may be beneficial in treatment for COVID-19. Read More

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http://dx.doi.org/10.1002/JLB.5COVR0620-306RDOI Listing

International Survey on Determinants of Antibiotic Duration and Discontinuation in Pediatric Critically Ill Patients.

Pediatr Crit Care Med 2020 Jun 29. Epub 2020 Jun 29.

Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada.

Objectives: We hypothesized that antibiotic use in PICUs is based on criteria not always supported by evidence. We aimed to describe determinants of empiric antibiotic use in PICUs in eight different countries.

Design: Cross-sectional survey. Read More

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http://dx.doi.org/10.1097/PCC.0000000000002397DOI Listing

Lung ultrasonography for early management of patients with respiratory symptoms during COVID-19 pandemic.

J Ultrasound 2020 Jul 7. Epub 2020 Jul 7.

Pulmonary Medicine Unit, Department of Medical and Surgical Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo Gemelli, 8, 00168, Rome, Italy.

COVID-19 pandemic is representing a serious challenge to worldwide public health. Lung Ultrasonography (LUS) has been signaled as a potential useful tool in this pandemic contest either to intercept viral pneumonia or to foster alternative paths. LUS could be useful in determining early lung involvement suggestive or not of COVID-19 pneumonia and potentially plays a role in managing decisions for hospitalization in isolation or admission in general ward. Read More

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http://dx.doi.org/10.1007/s40477-020-00501-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338342PMC

SARS-CoV-2 infection of primary human lung epithelium for COVID-19 modeling and drug discovery.

bioRxiv 2020 Jun 29. Epub 2020 Jun 29.

Coronavirus disease 2019 (COVID-19) is the latest respiratory pandemic resulting from zoonotic transmission of severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2). Severe symptoms include viral pneumonia secondary to infection and inflammation of the lower respiratory tract, in some cases causing death. We developed primary human lung epithelial infection models to understand responses of proximal and distal lung epithelium to SARS-CoV-2 infection. Read More

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http://dx.doi.org/10.1101/2020.06.29.174623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337376PMC

Infection with novel coronavirus (SARS-CoV-2) causes pneumonia in Rhesus macaques.

Cell Res 2020 Jul 7. Epub 2020 Jul 7.

Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei 430071, China.

The 2019 novel coronavirus (SARS-CoV-2) outbreak is a major challenge for public health. SARS-CoV-2 infection in human has a broad clinical spectrum ranging from mild to severe cases, with a mortality rate of ~6.4% worldwide (based on World Health Organization daily situation report). Read More

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http://dx.doi.org/10.1038/s41422-020-0364-zDOI Listing

Covid-19: unjustified risk to people held in immigration removal centres.

BMJ 2020 07 7;370:m2673. Epub 2020 Jul 7.

Medical Justice, London N7 7DT, UK.

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http://dx.doi.org/10.1136/bmj.m2673DOI Listing

Is stratified shielding from covid-19 feasible and ethical?

Authors:
Irene Petersen

BMJ 2020 07 7;370:m2660. Epub 2020 Jul 7.

Department of Primary Care and Population Health, Institute of Epidemiology and Health Care, University College London, London, UK.

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http://dx.doi.org/10.1136/bmj.m2660DOI Listing

Pathological, Bacteriological and Virological Findings in Sudden and Unexpected Deaths in Young Dogs.

Animals (Basel) 2020 Jul 3;10(7). Epub 2020 Jul 3.

Istituto Zooprofilattico Sperimentale del Mezzogiorno, Portici, 81100 Naples, Italy.

In human medicine, "sudden death" has been defined by the World Health Organization (WHO) as a non-violent, unexpected death occurring less than 24 h from the onset of symptoms. The aims of this study were: (1) to estimate the proportional mortality ratio for "sudden and unexpected death" (SUD) in young dogs; (2) to investigate the pathological and microbiological findings in SUD cases in young dogs. For these purposes, a retrospective study of a total of 145 cases of young dead dogs was performed. Read More

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http://dx.doi.org/10.3390/ani10071134DOI Listing

COVID-19 Treatment: Close to a Cure? - A Rapid Review of Pharmacotherapies for the Novel Coronavirus.

Int J Antimicrob Agents 2020 Jul 4:106080. Epub 2020 Jul 4.

University of Minnesota, Department of Pharmacy Services, Hennepin County Medical Center, Minneapolis, MN 55415.

Currently, there is no approved therapy for COVID-19. The World Health Organization therefore endorse supportive care only. However, frontline clinicians and researchers have been experimenting with several virus-based and host-based therapeutics since the outbreak in China. Read More

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http://dx.doi.org/10.1016/j.ijantimicag.2020.106080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334905PMC

Kinetics of viral load and antibody response in relation to COVID-19 severity.

J Clin Invest 2020 Jul 7. Epub 2020 Jul 7.

Department of Microbiology, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

The SARS-CoV-2 is the causative agent for COVID-19 pneumonia. Little is known about the kinetics, tissue distribution, cross-reactivity and neutralization antibody response in COVID-19 patients. Two groups of RT-PCR confirmed COVID-19 patients were enrolled in this study, including 12 severe patients in ICUs who needed mechanical ventilation and 11 mild patients in isolation wards. Read More

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http://dx.doi.org/10.1172/JCI138759DOI Listing

Editorial - COVID-19 pandemic outbreak and the Latin rule of Bernard de Clairvaux. Have we forgotten the past?

Eur Rev Med Pharmacol Sci 2020 06;24(12):7194-7195

Emergency Medicine and Internal Medicine and Gastroenterology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.

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http://dx.doi.org/10.26355/eurrev_202006_21715DOI Listing

Editorial - Children infected by SARS-CoV-2.

Eur Rev Med Pharmacol Sci 2020 06;24(12):7192-7193

Hangzhou Emergency Medical Center, Hangzhou, China.

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http://dx.doi.org/10.26355/eurrev_202006_21714DOI Listing

Rapid and sensitive diagnostic procedure for multiple detection of pandemic Coronaviridae family members SARS-CoV-2, SARS-CoV, MERS-CoV and HCoV: a translational research and cooperation between the Phan Chau Trinh University in Vietnam and University of Bari "Aldo Moro" in Italy.

Eur Rev Med Pharmacol Sci 2020 06;24(12):7173-7191

Phan Chau Trinh University of Medicine, Danang City, Vietnam.

Objective: A new pandemic coronavirus causing coronavirus disease-2019 (COVID-19), initially called 2019-nCoV and successively named Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The COVID-19 refers to the disease while the SARS-CoV-2 refers to the virus and is characterized by a rapid contagious capacity able to spread worldwide in a very short time. The rise in the number of infected patients and deaths is of great concern especially because symptoms are vague and similar to other forms of flu infection and corona syndrome infections characterized by fever, fatigue, dry cough, and dyspnea. Read More

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http://dx.doi.org/10.26355/eurrev_202006_21713DOI Listing

A nation-wide survey on emotional and psychological impacts of COVID-19 social distancing.

Eur Rev Med Pharmacol Sci 2020 06;24(12):7155-7163

Institute for Research on Population and Social Policies of the National Research Council of Italy (CNR-IRPPS), Rome, Italy.

Objective: Social distancing is crucial in order to flatten the curve of COVID-19 virus spreading. Isolation, scarcity of resources and the lack of social contacts may have produced a negative impact on people's emotions and psychological well-being. This study aims to explore the reasons and the ways through which social distancing generates negative emotions in individuals who experienced the lockdown. Read More

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http://dx.doi.org/10.26355/eurrev_202006_21711DOI Listing

COVID-19 with bronchogram - a potential indication of prolonged treatment.

Eur Rev Med Pharmacol Sci 2020 06;24(12):7149-7150

Kaifeng Central Hospital, Kaifeng Central Hospital of Xinxiang Medical University, Kaifeng, China.

Novel coronavirus disease-19 (COVID-19) has widely spread all over the world and seriously threatened people's health. This disease is currently diagnosed by clinical features, chest computed tomography (CT) scan, and nucleic acid test of severe acute respiratory syndrome coronavirus (SARS-CoV-2). Recently, some studies have suggested parenchymal consolidation and air bronchogram in severe cases. Read More

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http://dx.doi.org/10.26355/eurrev_202006_21709DOI Listing

The hemagglutinin-esterase gene in human coronaviruses SARS-CoV-2, HKU1 and OC43.

Authors:
S Soltani

Eur Rev Med Pharmacol Sci 2020 06;24(12):6484-6485

Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

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http://dx.doi.org/10.26355/eurrev_202006_21630DOI Listing

Reply Letter - COVID-19 (Novel Coronavirus 2019) - Recent trends.

Eur Rev Med Pharmacol Sci 2020 06;24(12):6482-6483

School of Medicine, The Maldives National University, Malé, Maldives.

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http://dx.doi.org/10.26355/eurrev_202006_21629DOI Listing

The complement inhibitors in COVID-19: future expectations.

Eur Rev Med Pharmacol Sci 2020 06;24(12):6480-6481

Sechenov First Moscow State Medical University, Moscow, Russian Federation.

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http://dx.doi.org/10.26355/eurrev_202006_21628DOI Listing

How to restructure the management of Italian oncological patients during and after COVID-19 pandemic?

Eur Rev Med Pharmacol Sci 2020 06;24(12):6478-6479

Division of Medical Oncology 1, IRCCS Regina Elena National Cancer Institute, Rome, Italy.

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http://dx.doi.org/10.26355/eurrev_202006_21626DOI Listing

SARS, MERS, COVID-19: Clinical Manifestations and Organ-System Complications: A Mini Review.

Pathog Dis 2020 Jul 7. Epub 2020 Jul 7.

Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Byblos, Lebanon.

Middle East Respiratory Syndrome (MERS), Severe Acute Respiratory Syndrome (SARS) and Coronavirus Disease 2019 (COVID-19) are caused by three distinct coronaviruses belonging to the same genus. COVID-19 and its two predecessors share many important features in their clinical presentations, and in their propensity for progression to severe disease which is marked by high rates of morbidity and mortality. However, comparison of the three viral illnesses also reveals a number of specific differences in clinical manifestations and complications, which suggest variability in the disease process. Read More

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http://dx.doi.org/10.1093/femspd/ftaa033DOI Listing

COVID-19 - more than respiratory disease: a gastroenterologist's perspective.

J Physiol Pharmacol 2020 Apr 2;71(2). Epub 2020 Jul 2.

Department of Medicine 1, Erlangen-Nuremberg, Germany.

Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV2) outbreak is the most dramatic event since World War II. Originating as a cluster of unexplained cases of pneumonia, it turned out that this viral disease termed COVID-19 is not only a respiratory infection, but a systemic disease associated with a number of extrapulmonary complications. One of the medical disciplines that is strongly affected by this viral infection is gastroenterology. Read More

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http://dx.doi.org/10.26402/jpp.2020.2.02DOI Listing

Too much information, too little evidence: is waste in research fuelling the covid-19 infodemic?

BMJ 2020 07 6;370:m2672. Epub 2020 Jul 6.

Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via Savi 10, 56126 Pisa, Italy.

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http://dx.doi.org/10.1136/bmj.m2672DOI Listing

Covid-19: research methods must be flexible in a crisis.

BMJ 2020 07 6;370:m2668. Epub 2020 Jul 6.

Department of Health Research, Ministry of Health and Family Welfare, Government of India, New Delhi, India.

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http://dx.doi.org/10.1136/bmj.m2668DOI Listing

Endemic and emerging coronavirus pulmonary infections.

Am J Med Sci 2020 Jun 12. Epub 2020 Jun 12.

Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine and Jane and Leonard Korman Respiratory Institute, 834 Walnut Street, Suite 650, Philadelphia, PA 19107, United States. Electronic address:

Coronaviruses are a well-known cause of upper and lower respiratory disease, and since 2002 have been a recognized source of potential pandemic spread. Over the past two decades, since the Severe Acute Respiratory Syndrome (SARS) outbreak, a large body of research has accumulated on the virology, clinical symptoms and signs, and experimental treatments of Coronaviruses. In 2020, a new form of Coronaviruses (SARS-CoV-2) emerged and spread rapidly throughout the globe. Read More

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http://dx.doi.org/10.1016/j.amjms.2020.06.013DOI Listing

Prevalence of stress, anxiety, depression among the general population during the COVID-19 pandemic: a systematic review and meta-analysis.

Global Health 2020 07 6;16(1):57. Epub 2020 Jul 6.

Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Background: The COVID-19 pandemic has had a significant impact on public mental health. Therefore, monitoring and oversight of the population mental health during crises such as a panedmic is an immediate priority. The aim of this study is to analyze the existing research works and findings in relation to the prevalence of stress, anxiety and depression in the general population during the COVID-19 pandemic. Read More

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http://dx.doi.org/10.1186/s12992-020-00589-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338126PMC

Clinical course and predictors of 60-day mortality in 239 critically ill patients with COVID-19: a multicenter retrospective study from Wuhan, China.

Crit Care 2020 07 6;24(1):394. Epub 2020 Jul 6.

Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: The global numbers of confirmed cases and deceased critically ill patients with COVID-19 are increasing. However, the clinical course, and the 60-day mortality and its predictors in critically ill patients have not been fully elucidated. The aim of this study is to identify the clinical course, and 60-day mortality and its predictors in critically ill patients with COVID-19. Read More

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http://dx.doi.org/10.1186/s13054-020-03098-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336107PMC

COVID-19: a hypothesis regarding the ventilation-perfusion mismatch.

Crit Care 2020 07 6;24(1):395. Epub 2020 Jul 6.

Radiology Department, Clínica Bupa Santiago, Av. Departamental 1455, La Florida, Santiago, Región Metropolitana, Chile.

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http://dx.doi.org/10.1186/s13054-020-03125-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338110PMC

Clarifying the controversial risk-benefit profile of soluble ACE2 in COVID-19.

Crit Care 2020 07 6;24(1):396. Epub 2020 Jul 6.

Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Republic of Singapore.

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http://dx.doi.org/10.1186/s13054-020-03097-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338146PMC

Race, socioeconomic deprivation, and hospitalization for COVID-19 in English participants of a national biobank.

Int J Equity Health 2020 07 6;19(1):114. Epub 2020 Jul 6.

Center for Genomic Medicine and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.

Preliminary reports suggest that the Coronavirus Disease 2019 (COVID- 19) pandemic has led to disproportionate morbidity and mortality among historically disadvantaged populations. We investigate the racial and socioeconomic associations of COVID- 19 hospitalization among 418,794 participants of the UK Biobank, of whom 549 (0.13%) had been hospitalized. Read More

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http://dx.doi.org/10.1186/s12939-020-01227-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336098PMC

Replication of a Dog-Origin H6N1 Influenza Virus in Cell Culture and Mice.

Viruses 2020 Jun 30;12(7). Epub 2020 Jun 30.

School of Veterinary Medicine, National Taiwan University, Taipei 10617, Taiwan.

The world's first natural avian-origin H6N1 influenza A virus infection case in dogs was confirmed in Taiwan in 2014. The H6N1 virus in chickens has been endemic in Taiwan since 1972. Whether the dog H6N1 virus has interspecies transmission potential is the key issue we aim to understand. Read More

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http://dx.doi.org/10.3390/v12070704DOI Listing

Failure of early extubation among cases of coronavirus disease-19 respiratory failure: Case report and clinical experience.

Medicine (Baltimore) 2020 Jul;99(27):e20843

Department of Emergency, the First Affiliated Hospital, Zhejiang University, Hangzhou, China.

Rationale: Extubation strategy for mechanically ventilated patients with Coronavirus Disease 19 is different from that for patients with other viral pneumonia. We reported 2 cases of Coronavirus Disease 19 receiving tracheal intubation twice during the hospitalization.

Patient Concerns: Two elderly patients with onset of fever and upper respiratory tract infection were confirmed as Coronavirus Disease 19, 1 of whom had chronic obstructive pulmonary disease previously. Read More

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http://dx.doi.org/10.1097/MD.0000000000020843DOI Listing

Other Respiratory Viruses as a Cause of Community-Acquired Pneumonia.

Authors:
James M Walter

Semin Respir Crit Care Med 2020 Aug 6;41(4):579-591. Epub 2020 Jul 6.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Community-acquired pneumonia (CAP) is a major cause of morbidity and mortality worldwide. There is growing appreciation of the burden of noninfluenza viral pathogens in CAP. Due to multiple factors including pneumococcal vaccination programs, declining rates of cigarette smoking, an aging population, and increasingly sensitive diagnostic tests, respiratory viruses are now the most common pathogens detected in CAP, outpacing . Read More

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http://dx.doi.org/10.1055/s-0040-1710537DOI Listing

Elucidating the Pivotal Role of Immune Players in the Management of COVID-19: Focus on Mesenchymal Stem Cells and Inflammation.

Curr Stem Cell Res Ther 2020 Jul 5. Epub 2020 Jul 5.

Department of Clinical Medicine, Habana Medical Center, Tamale. Ghana.

The world is currently engulfed with a viral disease with no cure. So, far, millions of people are infected with the virus across the length and breadth of world with thousand losing their lives each passing day. The WHO is February 2020 classified the virus as a coronavirus and the name Coronavirus-19 (CoV-19) was offered to the virus. Read More

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http://dx.doi.org/10.2174/1574888X15666200705213751DOI Listing
July 2020
2.861 Impact Factor

Intubation outside of the operating room: new challenges and opportunities in COVID-19 era.

Curr Opin Anaesthesiol 2020 Aug;33(4):608-611

aDepartment of Anesthesia, National University Hospital, Singapore bDepartment of Anesthesia and Pain Management, Toronto General Hospital cDepartment of Anesthesia and Pain Medicine, University of Toronto, Toronto, Ontario, Canada.

Purpose Of Review: Airway management in patients outside the operating room is associated with increased difficulties and risks, and the setting of the COVID-19 global pandemic adds another layer of complexity. Therefore, endotracheal intubation (ETT) of a patient who is presumptive COVID-19 or COVID-19 positive presents an additional challenge to an anesthesiologist. The aim of this review is to summarize the important principles of airway management outside of the operating room during the COVID-19 pandemic. Read More

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http://dx.doi.org/10.1097/ACO.0000000000000892DOI Listing