11,792 results match your criteria Pneumonia Viral


Influenza C virus in pre-school children with respiratory infections: retrospective analysis of data from the national influenza surveillance system in Germany, 2012 to 2014.

Euro Surveill 2019 Mar;24(10)

Robert Koch Institute, National Reference Center for Influenza, FG 17 Influenza and Other Respiratory Viruses, Berlin, Germany.

IntroductionRecent data on influenza C virus indicate a possible higher clinical impact in specified patient populations than previously thought.AimWe aimed to investigate influenza C virus circulation in Germany.MethodsA total of 1,588 samples from 0 to 4 year-old children presenting as outpatients with influenza-like illness (ILI) or acute respiratory infection were analysed retrospectively. Read More

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http://dx.doi.org/10.2807/1560-7917.ES.2019.24.10.1800174DOI Listing

Novel influenza A(H1N2) seasonal reassortant identified in a patient sample, Sweden, January 2019.

Euro Surveill 2019 Feb;24(9)

Unit for Laboratory Surveillance of Viral Pathogens and Vaccine Preventable Diseases, Department of Microbiology, the Public Health Agency of Sweden, Solna, Sweden.

In January 2019, a human seasonal reassortant influenza A(H1N2) virus with a novel 7:1 genetic constellation was identified in a 68-year-old female patient with suspected pneumonia. The virus harboured A(H3N2) neuraminidase and remaining genes from A(H1N1)pdm09. The patient recovered after severe illness. Read More

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https://www.eurosurveillance.org/content/10.2807/1560-7917.E
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http://dx.doi.org/10.2807/1560-7917.ES.2019.24.9.1900124DOI Listing
February 2019
1 Read

Comparison of Unyvero P55 Pneumonia Cartridge, in-house PCR and culture for the identification of respiratory pathogens and antibiotic resistance in bronchoalveolar lavage fluids in the critical care setting.

Eur J Clin Microbiol Infect Dis 2019 Mar 11. Epub 2019 Mar 11.

Medical Microbiology, Department of Laboratory Medicine, Royal Infirmary of Edinburgh, Edinburgh, EH16 4SA, UK.

Faster respiratory pathogen detection and antibiotic resistance identification are important in critical care due to the severity of illness, significant prior antibiotic exposure and infection control implications. Our objective was to compare the performance of the commercial Unyvero P55 Pneumonia Cartridge (Curetis AG) with routine bacterial culture methods and in-house bacterial multiplex real-time PCR assays. Seventy-four bronchoalveolar lavage specimens from patients admitted to a Scottish intensive care unit (ICU) over a 33-month period were tested prospectively by routine culture and viral PCR and retrospectively by Unyvero P55 and in-house bacterial PCR. Read More

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http://dx.doi.org/10.1007/s10096-019-03526-xDOI Listing

Optimizing treatment of respiratory tract infections in nursing homes: Nurse-initiated polymerase chain reaction testing.

Am J Infect Control 2019 Mar 6. Epub 2019 Mar 6.

National Centre for Antimicrobial Stewardship, Peter Doherty Institute for Infections and Immunity, Melbourne, Victoria, Australia; Department of Medicine, School of Clinical Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria, Australia; Monash Infectious Diseases and Infection Control and Epidemiology, Monash Health, Clayton, Victoria, Australia. Electronic address:

Background: Diagnostic testing using polymerase chain reaction (PCR) is infrequently initiated for diagnosis of respiratory tract infections (RTIs) in nursing homes. The objectives of this study were to determine the feasibility of implementing nurse-initiated PCR testing of respiratory specimens in nursing home settings and to compare antibiotic prescribing prior to and during the implementation.

Methods: This was a pragmatic, historically controlled study in 3 nursing homes (181 total beds) in Melbourne, Australia. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01966553193006
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http://dx.doi.org/10.1016/j.ajic.2019.02.001DOI Listing
March 2019
3 Reads

Broad-spectrum coronavirus antiviral drug discovery.

Expert Opin Drug Discov 2019 Apr 8;14(4):397-412. Epub 2019 Mar 8.

a Division of Molecular and Translational Sciences , United States Army Medical Research Institute of Infectious Diseases , Fort Detrick , MD , USA.

Introduction: The highly pathogenic coronaviruses severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) are lethal zoonotic viruses that have emerged into human populations these past 15 years. These coronaviruses are associated with novel respiratory syndromes that spread from person-to-person via close contact, resulting in high morbidity and mortality caused by the progression to Acute Respiratory Distress Syndrome (ARDS). Areas covered: The risks of re-emergence of SARS-CoV from bat reservoir hosts, the persistence of MERS-CoV circulation, and the potential for future emergence of novel coronaviruses indicate antiviral drug discovery will require activity against multiple coronaviruses. Read More

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https://www.tandfonline.com/doi/full/10.1080/17460441.2019.1
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http://dx.doi.org/10.1080/17460441.2019.1581171DOI Listing
April 2019
2 Reads

[Features of community-acquired pneumonia in immunocompetent hospitalized adults according to the causal agent].

Rev Med Chil 2018 Dec;146(12):1371-1383

Departamento de Enfermedades Respiratorias, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

Background: Molecular biological techniques allow the identification of more pathogens associated with community-acquired pneumonia (CAP).

Aim: To compare clinical and laboratory parameters of patients with CAP caused by different groups of pathogens.

Material And Methods: In a prospective study, immunocompetent adult patients hospitalized with CAP were tested for the presence of a broad range of possible respiratory pathogens using bacterial cultures, polymerase chain reaction, urinary antigen testing and serology. Read More

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http://dx.doi.org/10.4067/s0034-98872018001201371DOI Listing
December 2018
1 Read

Coincident airway exposure to low-potency allergen and cytomegalovirus sensitizes for allergic airway disease by viral activation of migratory dendritic cells.

PLoS Pathog 2019 Mar 7;15(3):e1007595. Epub 2019 Mar 7.

Institute for Virology and Research Center for Immunotherapy (FZI), University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.

Despite a broad cell-type tropism, cytomegalovirus (CMV) is an evidentially pulmonary pathogen. Predilection for the lungs is of medical relevance in immunocompromised recipients of hematopoietic cell transplantation, in whom interstitial CMV pneumonia is a frequent and, if left untreated, fatal clinical manifestation of human CMV infection. A conceivable contribution of CMV to airway diseases of other etiology is an issue that so far attracted little medical attention. Read More

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http://dx.doi.org/10.1371/journal.ppat.1007595DOI Listing
March 2019
2 Reads

Lifestyle risk factors, obesity and infectious disease mortality in the general population: Linkage study of 97,844 adults from England and Scotland.

Prev Med 2019 Mar 4;123:65-70. Epub 2019 Mar 4.

Department of Epidemiology and Public Health, University College London, London WC1E 6BT, United Kingdom; Charles Perkins Centre Epidemiology Unit, University of Sydney, Sydney, Australia; Prevention Research Collaboration, School of Public Health, University of Sydney, Sydney, Australia.

We examined associations between lifestyle variables and infectious disease mortality in a large general population cohort. A sample of 97,844 men and women (aged 47.1 ± 17. Read More

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http://dx.doi.org/10.1016/j.ypmed.2019.03.002DOI Listing
March 2019
2 Reads

Pneumonia severity index in viral community acquired pneumonia in adults.

PLoS One 2019 6;14(3):e0210102. Epub 2019 Mar 6.

Department of Internal Medicine, Keimyung University Dongsan Hospital, Daegu, Republic of Korea.

Pneumonia severity index (PSI) is an important scoring system that can assess the severity of community acquired pneumonia and determine admission status. However, there is a lack of research on whether this scoring system can be applied to viral community acquired pneumonia. The purpose of this study was to evaluate the usefulness of PSI in viral community acquired pneumonia. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210102PLOS
March 2019
2 Reads

The crystal structure of main protease from mouse hepatitis virus A59 in complex with an inhibitor.

Biochem Biophys Res Commun 2019 Mar 1. Epub 2019 Mar 1.

School of Life Sciences, Tianjin University, Tianjin, China. Electronic address:

Mouse hepatitis virus A59 (MHV-A59) is a representative member of the genus betacoronavirus within the subfamily Coronavirinae, which infects the liver, brain and respiratory tract. Through different inoculation routes, MHV-A59 can provide animal models for encephalitis, hepatitis and pneumonia to explore viral life machinery and virus-host interactions. In viral replication, non-structural protein 5 (Nsp5), also termed main protease (M), plays a dominant role in processing coronavirus-encoded polyproteins and is thus recognized as an ideal target of anti-coronavirus agents. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.02.105DOI Listing
March 2019
1 Read

[Application of multiplex PCR assay to study early multiple herpesviruses infection during HSCT].

Zhonghua Xue Ye Xue Za Zhi 2019 Feb;40(2):125-131

The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Institute of Blood and Marrow Transplantation, Suzhou 215006, China.

To investigate herpesvirus infection in early stage of hematopoietic stem cell transplantation (HSCT) by multiplex polymerase chain reaction (PCR), and to explore the association between multiple herpesviruses infection and clinical characteristics in HSCT patients and its impact on post-transplant complications and prognosis. A total of 734 peripheral blood samples were collected from 90 patients undergoing HSCT in the Department of Hematology, the First Affiliated Hospital of Soochow University between February 2017 and August 2017. The peripheral blood specimens were obtained before and within 90 days after transplantation at different time points. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2019.02.006DOI Listing
February 2019
1 Read

Guideline Adherence in Diagnostic Testing and Treatment of Community-Acquired Pneumonia in Children.

Pediatr Emerg Care 2019 Feb 14. Epub 2019 Feb 14.

Ann and Robert H Lurie Children's Hospital, Feinberg School of Medicine, Northwestern University, Chicago, IL.

Objectives: The objective of this study was to determine emergency department (ED) physician adherence with the 2011 Pediatric Infectious Diseases Society (PIDS) and Infectious Diseases Society of America (IDSA) guidelines for outpatient management of children with mild-to-moderate community-acquired pneumonia (CAP).

Methods: A cross-sectional survey of physicians on the American Academy of Pediatrics Section on Emergency Medicine Survey listserv was conducted. We evaluated ED physicians' reported adherence with the PIDS/IDSA guidelines through presentation of 4 clinical vignettes representing mild-to-moderate CAP of presumed viral (preschool-aged child), bacterial (preschool and school-aged child), and atypical bacterial (school-aged child) etiology. Read More

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http://dx.doi.org/10.1097/PEC.0000000000001745DOI Listing
February 2019
2 Reads

Influence of viral load in the outcome of hospitalized patients with influenza virus infection.

Eur J Clin Microbiol Infect Dis 2019 Feb 28. Epub 2019 Feb 28.

Department of Internal Medicine, University Hospital 12 de Octubre, Av. Córdoba km 5400, 28041, Madrid, Spain.

The role of viral load in the outcome of patients requiring hospital admission due to influenza is not well established. We aim to assess if there is an association between the viral load and the outcome in hospitalized patients with a confirmed influenza virus infection. A retrospective observational study including all adult patients who were hospitalized in our center with a confirmed influenza virus infection from January to May 2016. Read More

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http://link.springer.com/10.1007/s10096-019-03514-1
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http://dx.doi.org/10.1007/s10096-019-03514-1DOI Listing
February 2019
7 Reads

Influence of Obesity on Pneumococcus Infection Risk in the Elderly.

Front Endocrinol (Lausanne) 2019 13;10:71. Epub 2019 Feb 13.

Health Sciences North Research Institute, Sudbury, ON, Canada.

Obesity negatively affects immune function and host defense mechanisms. Obesity is associated with chronic activation of the innate immune system and consequent local and systemic inflammation which contribute to pathologic conditions such as type-2 diabetes mellitus, cancer, psoriasis, atherosclerosis, and inflammatory bowel disease. Individuals with obesity have increased susceptibility to contract viral, bacterial, and fungal infections and respond sub-optimally to vaccination. Read More

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https://www.frontiersin.org/article/10.3389/fendo.2019.00071
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http://dx.doi.org/10.3389/fendo.2019.00071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381016PMC
February 2019
4 Reads

Manning the Barricades: Lung Fibroblasts and CD4+ T Cells as the Last Line of Defense against Bacterial Invasion?

Crit Rev Immunol 2018 ;38(5):367-378

Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, Sir Henry Wellcome Laboratories, Southampton General Hospital, Southampton, United Kingdom; Wessex Investigational Sciences Hub, University of Southampton Faculty of Medicine, Southampton General Hospital, Southampton, United Kingdom.

Fibroblasts are a major structural cell in the human lung, being responsible for the production of extracellular matrix components that provide the intricate structure necessary for correct lung function. Generally located in the submucosa, fibroblasts do not usually directly interact with the commensal microbes that we now know are resident in the airways. However, during situations in which alveolar macrophages and epithelial cells are impaired, for example, during severe viral infections leading to pneumonia, bacteria can invade the lung mesenchyme. Read More

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http://dx.doi.org/10.1615/CritRevImmunol.2018026611DOI Listing
January 2018

[Place of biomarkers in the management of pulmonary infections].

Rev Mal Respir 2019 Feb 22. Epub 2019 Feb 22.

Service de réanimation médicale et des maladies infectieuses, hôpital Bichat-Claude-Bernard, HUPNVS, AP-HP, 75018 Paris, France; UMR 1137, IAME Team 5, DeSCID: decision sciences in infectious diseases, control and care, Sorbonne Paris Cité, Inserm/Paris Diderot University, 75018 Paris, France. Electronic address:

Introduction: The management of acute lower respiratory tract infections and, in particular, the decision whether or not to commence antibiotic therapy, still remains difficult in the absence of reliable clinical or radiological criteria allowing confident distinction between bacterial and viral infections. Numerous biomarkers have been developed to help the clinician in his/her diagnostic and therapeutic approach, but the role and significance of each has not been clearly defined.

Background: Though procalcitonin (PCT) or C-reactive protein (CRP) seem equal in helping the clinician to decide whether to commence antibiotic therapy or not during the course of an exacerbation of asthma or chronic obstructive pulmonary disease (COPD), PCT is currently the most useful biomarker to distinguish sepsis from other causes of inflammation and to determine the bacterial or viral origin of a pneumonia. Read More

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http://dx.doi.org/10.1016/j.rmr.2018.09.003DOI Listing
February 2019

[Clinical characteristics and T-lymphocyte subsets in 48 acquired immune deficiency syndrome patients with cytomegalovirus infections].

Zhonghua Nei Ke Za Zhi 2019 Mar;58(3):191-197

Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China (is working on the Department of Infectious Diseases, the Third Hospital of Qinhuangdao, Qinhuangdao 066000, China).

To investigate the clinical features and T lymphocytes subsets in patients with acquired immune deficiency syndrome (AIDS) and cytomegalovirus (CMV) infection. A total of 48 hospitalized patients with human immunodeficiency virus (HIV)-1/AIDS and CMV infections were recruited at Peking Union Medical College Hospital from Jan 2010 to Aug 2017. Their clinical features and immune function were retrospectively analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1426.2019.03.008DOI Listing
March 2019
2 Reads

The utility of peripheral blood leucocyte ratios as biomarkers in infectious diseases: A systematic review and meta-analysis.

J Infect 2019 Feb 22. Epub 2019 Feb 22.

Division of Genetics and Genomics, The Roslin Institute, University of Edinburgh, Edinburgh, UK; Intensive Care Unit, Royal Infirmary Edinburgh, Edinburgh, UK.

Objectives: To assess the utility of the neutrophil:lymphocyte (NLR), lymphocyte:monocyte (LMR) and platelet:lymphocyte ratios (PLR) as infection biomarkers.

Methods: PubMed/MEDLINE, Embase and Cochrane databases were searched to identify eligible articles. Studies of diagnosis, severity or outcome were included. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01634453193005
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http://dx.doi.org/10.1016/j.jinf.2019.02.006DOI Listing
February 2019
3 Reads

Pathologica in the time of "Spanish flu".

Pathologica 2018 Dec;110(4):316-320

Dipartimento di Oncologia ed Emato-Oncologia, Università degli Studi di Milano e SSD Psicologia Clinica, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italia.

The pandemic "Spanish flu", that in a few weeks of the autumn 1918 caused in Italy a number of deaths between 350.000 and 600.000, was widely discussed by the scientific community, although very little of that debate leaked out, because of the military censorship. Read More

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December 2018
2 Reads

Severe acute respiratory distress syndrome (ARDS) induced by human adenovirus B21: Report on 2 cases and literature review.

J Crit Care 2019 Feb 13;51:99-104. Epub 2019 Feb 13.

Institute for Infectious Diseases, University of Bern, Friedbuehlstrasse 51, 3010 Bern, Switzerland; Department of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 10, 3010 Bern, Switzerland. Electronic address:

Severe pneumonia and ARDS caused by human adenovirus B21 infections (HAdV-B21) is a rare, but a devastating disease with rapid progression to multiorgan failure and death. However, only a few cases were reported so far. Infections appear associated with increased disease severity and higher mortality in infected critically ill patients. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.02.019DOI Listing
February 2019

In Vivo Assessment of Antibody-Dependent Enhancement of Influenza B Infection.

Toxicol Sci 2019 Feb 22. Epub 2019 Feb 22.

Departments of Safety Assessment, Genentech, Inc., South San Francisco, CA.

A theoretical safety concern proposed in the influenza literature is that therapeutic anti-viral antibodies could have the potential for antibody-dependent enhancement (ADE) of infection and disease. ADE may occur when virus-specific antibodies at sub-therapeutic, non-neutralizing concentrations facilitate virus uptake and, in some cases, enhance replication, which can lead to an exacerbation of virus-mediated disease. Alternatively, ADE may occur due to antibody-dependent complement activation exacerbating virus-mediated disease in the absence of increased replication. Read More

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http://dx.doi.org/10.1093/toxsci/kfz053DOI Listing
February 2019
3 Reads

Enhanced IL-1β production is mediated by a TLR2-MYD88-NLRP3 signaling axis during coinfection with influenza A virus and Streptococcus pneumoniae.

PLoS One 2019 22;14(2):e0212236. Epub 2019 Feb 22.

Department of Biology, Missouri State University, Springfield, Missouri, United States of America.

Viral-bacterial coinfections, such as with influenza A virus and Streptococcus pneumoniae (S.p.), are known to cause severe pneumonia. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212236PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386446PMC
February 2019
2 Reads

Inducible lung epithelial resistance requires multisource reactive oxygen species generation to protect against bacterial infections.

PLoS One 2019 22;14(2):e0208216. Epub 2019 Feb 22.

Department of Pulmonary Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.

Pneumonia remains a global health threat, in part due to expanding categories of susceptible individuals and increasing prevalence of antibiotic resistant pathogens. However, therapeutic stimulation of the lungs' mucosal defenses by inhaled exposure to a synergistic combination of Toll-like receptor (TLR) agonists known as Pam2-ODN promotes mouse survival of pneumonia caused by a wide array of pathogens. This inducible resistance to pneumonia relies on intact lung epithelial TLR signaling, and inducible protection against viral pathogens has recently been shown to require increased production of epithelial reactive oxygen species (ROS) from multiple epithelial ROS generators. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208216PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386317PMC
February 2019
3 Reads

[Virus and Atypical Pathogens Detected in Community-Acquired Lower Respiratory Tract Infection in Infants and Children of Sfax Region, Tunisia].

Bull Soc Pathol Exot 2018 ;111(2):90-98

Laboratoire de microbiologie, faculté de médecine de Sfax, université de Sfax, Tunisie.

Little is known about viral and atypical bacteria pathogen spectra of community-acquired lower respiratory tract infection in children in Tunisia. Thus, a prospective study was carried out between January 2009 and March 2010 in Sfax. Nasopharyngeal aspirates collected from 368 patients (78 with pneumonia and 290 with acute bronchiolitis) were analyzed by indirect immunofluorescence assay and PCR to detect influenza viruses, parainfluenza viruses, respiratory syncytial virus (RSV), human metapneumovirus, human rhinovirus, human enterovirus, adenovirus, coronavirus, (Mpn) and (Cpn). Read More

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http://dx.doi.org/10.3166/bspe-2018-0024DOI Listing
January 2018
2 Reads

Characterization of the plasma proteome of nonhuman primates during Ebola virus disease or melioidosis: a host response comparison.

Clin Proteomics 2019 7;16. Epub 2019 Feb 7.

1Molecular and Translational Sciences Division, U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702 USA.

Background: In-depth examination of the plasma proteomic response to infection with a wide variety of pathogens can assist in the development of new diagnostic paradigms, while providing insight into the interdependent pathogenic processes which encompass a host's immunological and physiological responses. Ebola virus (EBOV) causes a highly lethal infection termed Ebola virus disease (EVD) in primates and humans. The Gram negative non-spore forming bacillus () causes melioidosis in primates and humans, characterized by severe pneumonia with high mortality. Read More

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http://dx.doi.org/10.1186/s12014-019-9227-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366079PMC
February 2019
3 Reads

arthritis and pneumonia in calves in Jordan: An emerging disease.

Vet World 2018 Dec 12;11(12):1663-1668. Epub 2018 Dec 12.

Department of Veterinary Clinical Sciences, Faculty of Veterinary Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan.

Aim: Clinical, microbiological, molecular, and pathological assays were undertaken to characterize an outbreak of increasingly reported signs of unresponsive arthritis and pneumonia of infection in young calves in Jordan.

Materials And Methods: Clinical history of the affected bovine herd was investigated for the presence of respiratory and/or joint problems. Two calves with such history were clinically examined and necropsied. Read More

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http://www.veterinaryworld.org/Vol.11/December-2018/3.html
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http://dx.doi.org/10.14202/vetworld.2018.1663-1668DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362338PMC
December 2018
6 Reads

Acute Respiratory Illness in Rural Haiti.

Int J Infect Dis 2019 Feb 14. Epub 2019 Feb 14.

Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA; Department of Health Services Research, Management and Policy, College of Public Health and Health Professions, University of Florida, Gainesville, FL. USA.

Objectives: Acute Respiratory Infection (ARI) is the most common cause of childhood morbidity and mortality in developing countries, including Haiti. Our objective was to detect pathogens found in children with ARI in rural Haiti to help develop evidence-based guidelines for treatment and prevention.

Methods: Retrospective study of students with ARI at four schools in rural Haiti. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.02.003DOI Listing
February 2019
1 Read
2.330 Impact Factor

[Experience of application of the PCR for identification of the causative agent of community acquired pneumonia in the military.]

Klin Lab Diagn 2018 ;63(10):641-645

«1586 Military Clinical Hospital» of the Ministry of Defense of the Russian Federation, 603105, Nizhniy Novgorod, Russian Federation.

Samples of sputum, blood, bronchoalveolar lavage, swabs from the oropharynx from 255 military personnel undergoing in-patient treatment with an x-ray confirmed diagnosis of community-acquired pneumonia (CAP) were examined by polymerase chain reaction (PCR). The comparison group was included 270 healthy recruits. The detection of S. Read More

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http://dx.doi.org/10.18821/0869-2084-2018-63-10-641-645DOI Listing
January 2018
6 Reads

Eculizumab in paroxysmal nocturnal haemoglobinuria and atypical haemolytic uraemic syndrome: 10-year pharmacovigilance analysis.

Br J Haematol 2019 Feb 15. Epub 2019 Feb 15.

Hannover Medical School, Hannover, Germany.

Eculizumab is the first and only medication approved for paroxysmal nocturnal haemoglobinuria (PNH) and atypical haemolytic uraemic syndrome (aHUS) treatment. However, eculizumab safety based on long-term pharmacovigilance is unknown. This analysis summarises safety data collected from spontaneous and solicited sources from 16 March 2007 through 1 October 2016. Read More

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http://dx.doi.org/10.1111/bjh.15790DOI Listing
February 2019
4 Reads

Update: Influenza Activity - United States, September 30, 2018-February 2, 2019.

MMWR Morb Mortal Wkly Rep 2019 Feb 15;68(6):125-134. Epub 2019 Feb 15.

Influenza Division, National Center for Immunization and Respiratory Diseases, CDC.

CDC collects, compiles, and analyzes data on influenza activity and viruses in the United States. During September 30, 2018-February 2, 2019,* influenza activity in the United States was low during October and November, increased in late December, and remained elevated through early February. As of February 2, 2019, this has been a low-severity influenza season (1), with a lower percentage of outpatient visits for influenza-like illness (ILI), lower rates of hospitalization, and fewer deaths attributed to pneumonia and influenza, compared with recent seasons. Read More

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http://www.cdc.gov/mmwr/volumes/68/wr/mm6806a1.htm?s_cid=mm6
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http://dx.doi.org/10.15585/mmwr.mm6806a1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375659PMC
February 2019
6 Reads

[Severe course of influenza B complicated by rhabdomyolysis and acute respiratory failure resulting in death].

Klin Mikrobiol Infekc Lek 2018 Dec;24(4):118-120

Department of Infectious Diseases, Faculty Hospital Ostrava, Czech Republic, e-mail:

Influenza is an acute viral disease that causes influenza A, B, C. Clinically, flu is typically characterized by fever and respiratory symptoms, sometimes with the need for mechanical ventilation, less frequently by gastrointestinal symptoms and muscle problems; severe are cases with central nervous system involvement. The most common complication of influenza is secondary bacterial infection, typically pneumonia, which is most frequently caused by pneumococci and staphylococci. Read More

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December 2018
2 Reads

First Complete Genome Sequence of Human Coronavirus HKU1 from a Nonill Bat Guano Miner in Thailand.

Microbiol Resour Announc 2019 Feb 7;8(6). Epub 2019 Feb 7.

Thai Red Cross Emerging Infectious Disease-Health Science Centre, World Health Organization Collaborating Centre for Research and Training on Viral Zoonoses, Chulalongkorn Hospital, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Human coronavirus HKU1 (HCoV-HKU1) was first detected in a patient with viral pneumonia from Hong Kong in 2004. Here, we report the first complete genome sequence of HCoV-HKU1 from Thailand, obtained from a nonill person who worked in a bat cave. Phylogenetic tree analysis revealed it as a group B HCoV-HKU1. Read More

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http://dx.doi.org/10.1128/MRA.01457-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368654PMC
February 2019
2 Reads

First Onset Herpesviral Infection and Lung Injury in Allogeneic Hematopoietic Cell Transplantation.

Am J Respir Crit Care Med 2019 Feb 11. Epub 2019 Feb 11.

Univ Michigan, Internal Medicine, Ann Arbor, Michigan, United States ;

Rationale: "Non-infectious" pulmonary complications are significant causes of morbidity and mortality post allogeneic hematopoietic cell transplant. Early onset viral reactivations or infections are common after transplant. Whether the first onset viral infection causes "non-infectious" pulmonary complications is unknown. Read More

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http://dx.doi.org/10.1164/rccm.201809-1635OCDOI Listing
February 2019
4 Reads

A case report of severe recurrent varicella in an ankylosing spondylitis patient treated with adalimumab - a new side effect after 15 years of usage.

BMC Infect Dis 2019 Feb 7;19(1):127. Epub 2019 Feb 7.

University Hospital for Infectious Diseases "Dr. Fran Mihaljević", Mirogojska 8, 10000, Zagreb, Croatia.

Background: Tumor necrosis factor-α (TNF-α) antagonists, most of which are monoclonal antibodies, became a widespread treatment for autoimmune diseases such as rheumatoid arthritis, ankylosing spondylitis, inflammatory bowel diseases, psoriasis, psoriatic arthritis, hidradenitis suppurativa and uveitis. Their use is based on the blockage of TNF-α, which plays an important role in granulomas formation, development of phagosomes, activation and differentiation of macrophages, immune response against viral pathogens. The multiple adverse effects of TNF-α inhibition have been identified, including a two-to four-fold increased risk of active tuberculosis and other granulomatous conditions and an increased occurrence of some other serious bacterial, fungal and certain viral infections. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-019-3768-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367735PMC
February 2019
2 Reads

Canadian and UK/Ireland practice patterns in lumbar puncture performance in febrile neonates with bronchiolitis.

Emerg Med J 2019 Mar 6;36(3):148-153. Epub 2019 Feb 6.

Division of Pediatric Emergency Medicine, Hospital for Sick Children, Toronto, Ontario, Canada.

Background: Serious bacterial infections in young infants with bronchiolitis are rare. Febrile infants <1 month old with bronchiolitis often receive a lumbar puncture (LP), despite limited data for this practice and lack of clinical practice guidelines for this population. The primary objective was to investigate practice patterns in performance of LPs in the ED management of febrile infants aged ≤30 days with bronchiolitis. Read More

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http://dx.doi.org/10.1136/emermed-2018-208000DOI Listing
March 2019
1 Read

Challenges in severe community-acquired pneumonia: a point-of-view review.

Intensive Care Med 2019 Feb 31;45(2):159-171. Epub 2019 Jan 31.

Pulmonary and Critical Care Division, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Purpose: Severe community-acquired pneumonia (SCAP) is still associated with substantial morbidity and mortality. In this point-of-view review paper, a group of experts discuss the main controversies in SCAP: the role of severity scores to guide patient settings of care and empiric antibiotic therapy; the emergence of pathogens outside the core microorganisms of CAP; viral SCAP; the best empirical treatment; septic shock as the most lethal complication; and the need for new antibiotics.

Methods: For all topics, the authors describe current controversies and evidence and provide recommendations and suggestions for future research. Read More

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http://dx.doi.org/10.1007/s00134-019-05519-yDOI Listing
February 2019

Morbidity and mortality of the Russian population from acute respiratory viral infections, pneumonia and vaccination.

Ter Arkh 2018 Feb;90(1):22-26

Research Institute of Pulmonology Federal medico-biological agency, Moscow, Russia.

Aim: In order to assess the impact of influenza vaccination and pneumococcal infection (PI) were studied seasonal morbidity and mortality because of influenza, acute respiratory viral infections (ARVI) and pneumonia among the population of the Russian Federation during 2012-2016 timeframe.

Materials And Methods: There were analyzed the data of Federal service for surveillance in consumer rights protection and human welfare (Rospotrebnadzor) on influenza vaccination and PI and ARVI morbidity (including influenza), diseases of the respiratory system (DRS). The information on mortality of the population of Russia because of these diseases received from official publications of the Federal State statistics service (Rosstat) and The Ministry of health of the Russian Federation (Ministry of Health of Russia) on the mortality rates of the population of Russia because of these illnesses. Read More

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http://dx.doi.org/10.26442/terarkh201890122-26DOI Listing
February 2018
1 Read

Prolonged shedding of type 55 human adenovirus in immunocompetent adults with adenoviral respiratory infections.

Eur J Clin Microbiol Infect Dis 2019 Jan 29. Epub 2019 Jan 29.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Ilwon-ro 81, Gangnam-gu, Seoul, Republic of Korea.

Human adenovirus (HAdV) is a common pathogen causing respiratory infections with outbreaks reported in the military and community. However, little information is available on the shedding kinetics. We performed a prospective study of immunocompetent adults confirmed with HAdV respiratory infection by multiplex real-time PCR during an outbreak of HAdV-55. Read More

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http://dx.doi.org/10.1007/s10096-019-03471-9DOI Listing
January 2019
2 Reads

The incidence, etiologies, outcomes, and predictors of mortality of acute liver failure in Thailand: a population-base study.

BMC Gastroenterol 2019 Jan 28;19(1):18. Epub 2019 Jan 28.

Institute for Liver and Digestive Health, Royal Free Hospital, University College London, London, UK.

Background: Acute liver failure (ALF) is uncommon but progresses rapidly with high mortality. We investigated the incidence, etiologies, outcomes, and predictive factors for 30-day mortality in patients with ALF.

Methods: We conducted a population-based study of ALF patients hospitalized between 2009 and 2013 from the Thai Nationwide Hospital Admission database, which comprises 76% of all admissions from 858 hospitals across 77 provinces in Thailand. Read More

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http://dx.doi.org/10.1186/s12876-019-0935-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348628PMC
January 2019
7 Reads
2.365 Impact Factor

Effect of experimental Ornithobacterium rhinotracheale infection along with live infectious bronchitis vaccination in broiler chickens.

Poult Sci 2019 Jan;98(1):105-111

Department of Animal Production, College of Food and Agriculture Sciences, King Saud University, P.O. Box 2460, Riyadh 11451, Saudi Arabia.

Ornithobacterium rhinotracheale (ORT), a bacterium causing respiratory tract infection, has led to a significant problem in the intensive poultry production in Egypt. Polymerase chain reaction-amplified 784-bp specific ORT DNA fragments were found in 7 ORT isolates from lungs, air sacs, and tracheas of commercial broilers or layers in Egypt in 2015. The objective of this study was to investigate the role of the live variant IBV 4/91 with ORT infection. Read More

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http://dx.doi.org/10.3382/ps/pey324DOI Listing
January 2019
1 Read

Macrolides in critically ill patients with Middle East Respiratory Syndrome.

Int J Infect Dis 2019 Jan 25;81:184-190. Epub 2019 Jan 25.

International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, United States. Electronic address:

Objectives: Macrolides have been reported to be associated with improved outcomes in patients with viral pneumonia related to influenza and other viruses, possibly because of their immune-modulatory effects. Macrolides have frequently been used in patients with Middle East Respiratory Syndrome (MERS). This study investigated the association of macrolides with 90-day mortality and MERS coronavirus (CoV) RNA clearance in critically ill patients with MERS. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.01.041DOI Listing
January 2019
5 Reads
2.330 Impact Factor

Population-based estimates of the burden of pneumonia hospitalizations in Hong Kong, 2011-2015.

Eur J Clin Microbiol Infect Dis 2019 Mar 25;38(3):553-561. Epub 2019 Jan 25.

Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, Laboratory Block, University of Hong Kong, 2/F, 21 Sassoon Road, Hong Kong Special Administrative Region, China.

Up-to-date data on the burden of disease are important to identify patients with unmet needs and to optimize healthcare resources. We aimed to characterize the burden of pneumonia hospitalizations in Hong Kong and inform targeted healthcare policies for pneumonia control in the era of global aging. This was a population-based study using a territory-wide administrative electronic health record system that covers all public hospitals of Hong Kong. Read More

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http://dx.doi.org/10.1007/s10096-018-03459-xDOI Listing
March 2019
6 Reads

Infectious complications following heart transplantation in the era of high-priority allocation and extracorporeal membrane oxygenation.

Ann Intensive Care 2019 Jan 25;9(1):17. Epub 2019 Jan 25.

Medical and Infectious Diseases Intensive Care Unit, AP-HP, Bichat-Claude Bernard University Hospital, 46 rue Henri Huchard, 75877, Paris Cedex, France.

Background: Infectious complications are a major cause of morbidity and mortality after heart transplantation (HT). However, the epidemiology and outcomes of these infections in the recent population of adult heart transplant recipients have not been investigated.

Methods: We conducted a single-center retrospective study on infectious complications occurring within 180 days following HT on consecutive heart transplant recipients, from January 2011 to June 2015 at Bichat University Hospital in Paris, France. Read More

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http://dx.doi.org/10.1186/s13613-019-0490-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347647PMC
January 2019
2 Reads

Cytomegalovirus pneumonia in a patient with T-lymphoblastic leukemia/lymphoma after allogeneic hematopoietic stem cell transplantation: A case report.

Medicine (Baltimore) 2019 Jan;98(4):e14221

Department of Respiratory and Critical Care Medicine, Peking University Third Hospital.

Rationale: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an important treatment for hematological malignancies. Common complications are opportunistic infections and graft-versus-host disease (GVHD). Cytomegalovirus (CMV) is one of the most common causes of opportunistic infections. Read More

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http://dx.doi.org/10.1097/MD.0000000000014221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358403PMC
January 2019
1 Read

Risk of serious infections in tocilizumab versus other biologic drugs in patients with rheumatoid arthritis: a multidatabase cohort study.

Ann Rheum Dis 2019 Apr 24;78(4):456-464. Epub 2019 Jan 24.

Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, Boston, Massachusetts, USA

Objective: To investigate the rate of serious bacterial, viral or opportunistic infection in patients with rheumatoid arthritis (RA) starting tocilizumab (TCZ) versus tumour necrosis factor inhibitors (TNFi) or abatacept.

Methods: Using claims data from US Medicare from 2010 to 2015, and IMS and MarketScan from 2011 to 2015, we identified adults with RA who initiated TCZ or TNFi (primary comparator)/abatacept (secondary comparator) with prior use of ≥1 different biologic drug or tofacitinib. The primary outcome was hospitalised serious infection (SI), including bacterial, viral or opportunistic infection. Read More

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2018-21436
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http://dx.doi.org/10.1136/annrheumdis-2018-214367DOI Listing
April 2019
10 Reads

[Status of antibiotic use in hospitalized children with community-acquired pneumonia in multiple regions of China].

Zhongguo Dang Dai Er Ke Za Zhi 2019 Jan;21(1):11-17

First Clinical Medical Institute, Liaoning University of Traditional Chinese Medicine, Shenyang 110032, China.

Objective: To investigate the use of antibiotics in children with community-acquired pneumonia (CAP) in multiple regions of China, and to provide a reference for CAP standard treatment and rational antibiotic use in children.

Methods: The medical data of 1 383 children with CAP who were hospitalized in the department of pediatrics in 10 grade A tertiary hospitals from 9 cities between April 14, 2014 and January 1, 2016 were reviewed, to analyze the status of antibiotic use in hospitalized children in North China, Northeast China, East China, and South China.

Results: The overall rate of antibiotic use in children with CAP was 89. Read More

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January 2019
6 Reads

Burden of Respiratory Syncytial Virus Disease and Mortality Risk Factors in Argentina: 18 Years Active Surveillance in a Children´s Hospital.

Pediatr Infect Dis J 2019 Jan 10. Epub 2019 Jan 10.

Virology, Ricardo Gutiérrez Children's Hospital, Buenos Aires, Argentina.

Background: Respiratory Syncytial Virus (RSV) is the leading cause of acute lower respiratory infection (ALRI) in children. We aimed to describe the clinical-epidemiological pattern and risk factors for mortality associated with RSV infection.

Methods: A prospective, cross-sectional study of ALRI in children admitted to the Children's Hospital among 2000-2017. Read More

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http://Insights.ovid.com/crossref?an=00006454-900000000-9646
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http://dx.doi.org/10.1097/INF.0000000000002271DOI Listing
January 2019
11 Reads

The evolving burden of viruses in pneumonia.

Curr Opin Infect Dis 2019 Apr;32(2):158-162

Pulmonary and Critical Care Medicine Service, Medstar Washington Hospital Center, Washington, DC, USA.

Purpose Of Review: To describe the evolving microbiology of various forms of pneumonia and the importance of viruses as etiologic causes of pneumonia.

Recent Findings: Multiple studies utilizing novel diagnostic modalities demonstrate that the prevalence of viruses as causes for pneumonia varies from approximately 10-30% depending on the specific pneumonia type evaluated. Viral pneumonias appear similar in presentation and severity of illness to bacterial causes of pulmonary infection. Read More

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http://dx.doi.org/10.1097/QCO.0000000000000536DOI Listing
April 2019
6 Reads

CSV2018: The 2nd Symposium of the Canadian Society for Virology.

Viruses 2019 Jan 18;11(1). Epub 2019 Jan 18.

Department of Microbiology and Immunology, Dalhousie University, 5850 College Street, Halifax, NS B3H 4R2, Canada.

The 2nd Symposium of the Canadian Society for Virology (CSV2018) was held in June 2018 in Halifax, Nova Scotia, Canada, as a featured event marking the 200th anniversary of Dalhousie University. CSV2018 attracted 175 attendees from across Canada and around the world, more than double the number that attended the first CSV symposium two years earlier. CSV2018 provided a forum to discuss a wide range of topics in virology including human, veterinary, plant, and microbial pathogens. Read More

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http://dx.doi.org/10.3390/v11010079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356965PMC
January 2019
3 Reads

Identfication of viral and bacterial etiologic agents of the pertussis-like syndrome in children under 5 years old hospitalized.

BMC Infect Dis 2019 Jan 21;19(1):75. Epub 2019 Jan 21.

School of Medicine. Research and Innovation Centre of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima, Peru.

Background: Acute respiratory infections (ARIs) represent an important cause of morbidity and mortality in children, remaining a major public health concern, especially affecting children under 5 years old from low-income countries. Unfortunately, information regarding their epidemiology is still limited in Peru.

Methods: A secondary data analysis was performed from a previous cross-sectional study conducted in children with a probable diagnosis of Pertussis from January 2010 to July 2012. Read More

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http://dx.doi.org/10.1186/s12879-019-3671-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341522PMC
January 2019
3 Reads