100,561 results match your criteria Pneumonia Viral


Post-mortem CT lung findings at a medicolegal institute in SARS-CoV-2 RT-PCR positive cases with autopsy correlation.

Forensic Sci Med Pathol 2021 Jun 23. Epub 2021 Jun 23.

Department of Forensic Pathology, Victorian Institute of Forensic Medicine, Southbank, Australia.

CoVID-19 is a novel viral infection with now well-established clinical radiological findings. There is limited data on post-mortem imaging. We explore the proposition that PMCT could be used as screening test. Read More

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Taskforce report on the diagnosis and clinical management of COVID-19 associated pulmonary aspergillosis.

Intensive Care Med 2021 Jun 23. Epub 2021 Jun 23.

Department of Intensive Care Medicine, Multidisciplinary Intensive Care Research Organization (MICRO), St. James's Hospital, Dublin, Ireland.

Purpose: Invasive pulmonary aspergillosis (IPA) is increasingly reported in patients with severe coronavirus disease 2019 (COVID-19) admitted to the intensive care unit (ICU). Diagnosis and management of COVID-19 associated pulmonary aspergillosis (CAPA) are challenging and our aim was to develop practical guidance.

Methods: A group of 28 international experts reviewed current insights in the epidemiology, diagnosis and management of CAPA and developed recommendations using GRADE methodology. Read More

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Complicated pulmonary human coronavirus-NL63 infection after a second allogeneic hematopoietic stem cell transplantation for acute B-lymphocytic leukemia: A case report.

Medicine (Baltimore) 2021 Jun;100(25):e26446

Department of Bone Marrow Transplantation.

Rationale: Viruses are the most common pathogens that can cause infection-related non-recurrent death after transplantation, occurring mostly from the early stages of hematopoietic stem cell transplantation (HSCT) to within 1 year after transplantation. Human coronavirus (HCoV)-NL63 is a coronavirus that could cause mortality among patients with underlying disease complications. Serological tests are of limited diagnostic value in immunocompromised hosts and cases of latent infection reactivation. Read More

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Rhinovirus Reduces the Severity of Subsequent Respiratory Viral Infections by Interferon-Dependent and -Independent Mechanisms.

mSphere 2021 Jun 23:e0047921. Epub 2021 Jun 23.

Institute for Modeling Collaboration and Innovation, University of Idahogrid.266456.5, Moscow, Idaho, USA.

Coinfection by heterologous viruses in the respiratory tract is common and can alter disease severity compared to infection by individual virus strains. We previously found that inoculation of mice with rhinovirus (RV) 2 days before inoculation with a lethal dose of influenza A virus [A/Puerto Rico/8/34 (H1N1) (PR8)] provides complete protection against mortality. Here, we extended that finding to a second lethal respiratory virus, pneumonia virus of mice (PVM), and analyzed potential mechanisms of RV-induced protection. Read More

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Recent advances in antibody-based immunotherapy strategies for COVID-19.

J Cell Biochem 2021 Jun 23. Epub 2021 Jun 23.

Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

The emergence of a new acute respiratory syndrome Coronavirus 2 (SARS-CoV-2), the cause of the 2019-nCOV disease (COVID-19), has caused a pandemic and a global health crisis. Rapid human-to-human transmission, even from asymptomatic individuals, has led to the quick spread of the virus worldwide, causing a wide range of clinical manifestations from cold-like symptoms to severe pneumonia, acute respiratory distress syndrome (ARDS), multiorgan injury, and even death. Therefore, using rapid and accurate diagnostic methods to identify the virus and subsequently select appropriate and effective treatments can help improvement of patients and control the pandemic. Read More

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COVID-19: Histopathological correlates of imaging patterns on chest computed tomography.

Respirology 2021 Jun 22. Epub 2021 Jun 22.

Department of Pathology, Cancer Centre Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Background And Objective: Patients with coronavirus disease 2019 (COVID-19) pneumonia present with typical findings on chest computed tomography (CT), but the underlying histopathological patterns are unknown. Through direct regional correlation of imaging findings to histopathological patterns, this study aimed to explain typical COVID-19 CT patterns at tissue level.

Methods: Eight autopsy cases were prospectively selected of patients with PCR-proven COVID-19 pneumonia with varying clinical manifestations and causes of death. Read More

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The Current Status and Challenges in the Development of Vaccines and Drugs against Severe Acute Respiratory Syndrome-Corona Virus-2 (SARS-CoV-2).

Biomed Res Int 2021 1;2021:8160860. Epub 2021 Jun 1.

Center of Excellence in Molecular Biology and Regenerative Medicine (CEMR), Department of Biochemistry, JSS Academy of Higher Education & Research (JSS AHER), Mysore, 570015 Karnataka, India.

Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection causes coronavirus disease-19 (COVID-19), which is characterized by clinical manifestations such as pneumonia, lymphopenia, severe acute respiratory distress, and cytokine storm. S glycoprotein of SARS-CoV-2 binds to angiotensin-converting enzyme II (ACE-II) to enter into the lungs through membrane proteases consequently inflicting the extensive viral load through rapid replication mechanisms. Despite several research efforts, challenges in COVID-19 management still persist at various levels that include (a) availability of a low cost and rapid self-screening test, (b) lack of an effective vaccine which works against multiple variants of SARS-CoV-2, and (c) lack of a potent drug that can reduce the complications of COVID-19. Read More

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Coronavirus disease 2019 (COVID-19) in a Chinese renal transplant recipient: a case report.

Transl Androl Urol 2021 May;10(5):2140-2148

Department of Pulmonary and Critical Care Medicine, Shengjing Hospital of China Medical University, Shenyang, China.

Since December 2019, a novel coronavirus that caused viral pneumonia broke out and became global pandemic. Coronavirus disease 2019 (COVID-19) is caused by the SARS-CoV-2 virus. Reports on the clinical manifestations in solid organ transplant (SOT) recipients are rare. Read More

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Post-COVID-19 Benign Paroxysmal Positional Vertigo.

Case Rep Med 2021 1;2021:9967555. Epub 2021 Jun 1.

Department of Otorhinolaryngology and Head and Neck Surgery, Zagreb School of Medicine, University Hospital Center "Sestre Milosrdnice", Zagreb, Croatia.

Background: COVID-19 is a disease caused by a new strain of coronavirus (SARS-COVID-19). The WHO first learned about this new virus on December 31, 2019, following a report on a group of cases of "viral pneumonia" in Wuhan, People's Republic of China, and declared a pandemic in March 2020. The disease was an almost complete unknown at the outset, but knowledge of its pathophysiology, clinical picture, and treatment options grew and developed rapidly. Read More

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Bacterial and viral respiratory tract microbiota and host characteristics in adults with lower respiratory tract infections: a case-control study.

Clin Infect Dis 2021 Jun 22. Epub 2021 Jun 22.

Center for Experimental and Molecular Medicine (CEMM), Amsterdam University Medical Centers - Location AMC, University of Amsterdam, Amsterdam, The Netherlands.

Background: Viruses and bacteria from the nasopharynx are capable of causing community-acquired pneumonia (CAP), which can be difficult to diagnose. We aimed to investigate whether shifts in the composition of these nasopharyngeal microbial communities can be used as diagnostic biomarkers for CAP in adults.

Methods: We collected nasopharyngeal swabs from adult CAP patients and controls without infection in a prospective multicenter case-control study design. Read More

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ACUTE TRANSVERSE MYELITIS AS A NEUROLOGICAL COMPLICATION OF COVID-19: A CASE REPORT.

Wiad Lek 2021 ;74(4):1045-1049

STATE UNIVERSITY "UZHHOROD NATIONAL UNIVERSITY", UZHHOROD, UKRAINE.

We aim to report a COVID-19-related case of acute myelitis that has not been associated with any other viral infections. A 23-year-old student was admitted to the hospital within a month from the time of loss of smell and taste with features of acute-onset non-compressive myelitis with paresthesia on both sides from the Th9 level. Complex neurological, clinical, laboratory, and neuroimaging examination was performed within 24 hours of admission. Read More

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EPIDEMIOLOGICAL FEATURES OF SARS2 COVID-19 OUTBREAK DURING 2020 AMONG RT-PCR CONFIRMED CASES IN ZAKARPATTYA.

Wiad Lek 2021 ;74(4):961-965

STATE HIGHER EDUCATION ESTABLISHMENT UZHHOROD NATIONAL UNIVERSITY, UZHHOROD, UKRAINE.

Objective: The aim: The overall aim of this project was to provide a comprehensive description of epidemiological and demographic features of SARS2 COVID19 outbreak among patients in Zakarpattya oblast during 2020 to define most vulnerable and susceptible groups of population.

Patients And Methods: Materials and methods: We conducted a retrospective observational descriptive study of the 33 190 cases that tested RT-PCR positive for SARS 2 COVI19 in Zakarpattya oblast, studied their comorbidities and concomitant diseases, as well as their clinical and functional outcomes.

Results: Results: Among studied cases: females - 20 069 (60. Read More

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SARS-CoV-2 Myocarditis Due to Severe Obesity.

Cureus 2021 May 17;13(5):e15074. Epub 2021 May 17.

Internal Medicine, Chicago Medical School Internal Medicine Residency Program at Northwestern Medicine McHenry Hospital, McHenry, USA.

Myocarditis is defined as a myocardial injury concomitant with myocardial dysfunction. Several causes are associated with it, including infectious versus inflammatory and inherited cardiomyopathies. It can be acute, subacute, or chronic, and it can present as focal versus diffuse myocardial dysfunction. Read More

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Fulminant granulomatosis with polyangiitis presenting with diffuse alveolar haemorrhage following COVID-19.

BMJ Case Rep 2021 Jun 21;14(6). Epub 2021 Jun 21.

Mercy Health St. Mary's Division of Infectious Disease and Michigan State University College of Human Medicine Department of Medicine, Michigan State University College of Human Medicine, Grand Rapids, Michigan, USA.

A 40-year-old man developed granulomatosis with polyangiitis (GPA) following a mild case of COVID-19. Initially, he experienced mild migrating joint pain for 2 months prior to testing positive for SARS-CoV-2 but dramatically worsened following resolution of his infection. The pain continued to progress until he suddenly develope haemoptysis, prompting him to present to a local hospital. Read More

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Trigeminal and cervical radiculitis after tozinameran vaccination against COVID-19.

BMJ Case Rep 2021 Jun 21;14(6). Epub 2021 Jun 21.

National Neuroscience Institute - Singapore General Hospital Campus, Singapore.

In this report, we describe a patient who developed an acute trigeminal neuritis and cervical radiculitis after receiving a Pfizer-BioNtech vaccination (tozinameran) against SARS-CoV-2. Read More

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Study protocol of a factorial trial ECHO: optimizing a group-based school intervention for children with emotional problems.

BMC Psychol 2021 Jun 21;9(1):97. Epub 2021 Jun 21.

The Center for Child and Adolescent Mental Health - Eastern and Southern Norway, Postboks 4623, 0405, Nydalen, Oslo, Norway.

Background: Youth mental health problems are a major public health concern. Anxiety and depression are among the most common psychological difficulties. The aim of this study is to evaluate an optimized version of a promising indicated group intervention for emotional problems. Read More

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[COVID-19 and vaccination: analysis of public institution's role in information spread through Twitter.]

Rev Esp Salud Publica 2021 Jun 16;95. Epub 2021 Jun 16.

Facultad de Ciencias de la Salud. Universidad Alfonso X el Sabio. Villanueva de la Cañada. Madrid. España.

Objective: The COVID-19 pandemic has been a time where social media allows increased conversations about it. These conversations have spread various conspiracies about vaccines against COVID-19. It is, therefore, necessary to develop communication strategies, led by official accounts, that offer accessible information on vaccination as a preventive public health strategy. Read More

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Comparison of the SARS-CoV-2-inactivating activities of the differently manufactured hypochlorous acid water products with various pH.

J Water Health 2021 Jun;19(3):448-456

Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, 2-11 Inada, Obihiro, Hokkaido 080-8555, Japan E-mail:

The use of effective disinfectants is a key method of controlling the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Hypochlorous acid water (HAW) has a broad spectrum of virucidal activities. We previously reported that acidic electrolyzed water, one of the HAW products, had potent SARS-CoV-2-inactivating activity and showed promise as a disinfectant. Read More

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MedTech Forum 2021 (April 20-22, 2021 - Virtual Meeting).

Authors:
M Colina

Drugs Today (Barc) 2021 Jun;57(6):401-405

Clarivate, Barcelona, Spain.

The MedTech Forum 2021 was an online event at which participants from the field of medical devices, diagnostics and digital health openly shared their views on the latest trends, challenges and opportunities currently being faced. The event enticed representatives from around 30 companies from the healthcare sector, as well as those from competent authorities, notified bodies, healthcare providers, academia and patients. Parallel sessions distributed across 3 days enabled the audience to interact with the speakers through a live-chat platform. Read More

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Educational Attainment Decreases the Risk of COVID-19 Severity in the European Population: A Two-Sample Mendelian Randomization Study.

Front Public Health 2021;9:673451. Epub 2021 Jun 3.

Department of Computational Diagnostic Radiology and Preventive Medicine, The University of Tokyo Hospital, Tokyo, Japan.

Observational studies have reported that the severity of COVID-19 depends not only on physical conditions but also on socioeconomic status, including educational level. Because educational attainment (EA), which measures the number of years of schooling, is moderately heritable, we investigated the causal association of EA on the risk of COVID-19 severity using the Mendelian randomization (MR) approach. A two-sample MR analysis was performed using publicly available summary-level data sets of genome-wide association studies (GWASs). Read More

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Perceived Stress During the COVID-19-Related Confinement in Cyprus.

Front Public Health 2021;9:673411. Epub 2021 Jun 2.

Department of Health Sciences, School of Sciences, European University Cyprus, Nicosia, Cyprus.

The COVID-19 pandemic is a serious global health emergency that could potentially have a significant impact on both somatic as well as psychological level. The aim of this study was to assess the prevalence of perceived stress in the general adult population of Cyprus during the first COVID-19 lockdown period. This was an internet-based cross-sectional study conducted between 6 April and 20 June 2020, one to two and a half months after the introduction of and the first mandatory lockdown on its entire territory imposed by the government of the Republic of Cyprus on 24 March 2020. Read More

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The Role of Self-Efficacy and Injunctive Norms in Helping Older Adults Decide to Stay Home During the COVID-19 Pandemic.

Front Public Health 2021 4;9:660813. Epub 2021 Jun 4.

Department of Applied Health Science, School of Public Health, Indiana University, Bloomington, IN, United States.

Because older adults are at elevated risk of COVID-19-related adverse health outcomes, and staying at home is an effective strategy to avoid unnecessary exposures, the current formative study used the Reasoned Action Approach (RAA) to identify the beliefs underlying older adults' decision to stay home for the next month. The participants (weighted = 206, age 65-94) for the current study were selected from a nationally representative online survey of US adults from April 10-20, 2020. We used multiple linear regression to estimate the relative contribution of the four RAA global constructs (instrumental attitude, injunctive norms, descriptive norms, and self-efficacy) in explaining intention to stay home after controlling for demographic covariates. Read More

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Knowledge, Attitude, and Self-Reported Practice Towards Measures for Prevention of the Spread of COVID-19 Among Australians: A Nationwide Online Longitudinal Representative Survey.

Front Public Health 2021;9:630189. Epub 2021 Jun 2.

Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Clayton, VIC, Australia.

To assess and share learnings on the motivators and behavioural adherence across sex and age to evolving strategies in public policy to prevent the spread of SARS-CoV-2 at the end of a first COVID-19 wave and the beginning of a second COVID-19 wave in Australia. A national longitudinal survey using a framework based on evidence-based behaviour change models. The survey was administered to a national sample representative across sex, age and location was undertaken at two time points: May 1st to 5th, 2020, and July 1st to 7th, 2020. Read More

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Outdoor Physical Activity During the First Wave of the COVID-19 Pandemic. A Comparative Analysis of Government Restrictions in Italy, France, and Germany.

Front Public Health 2021;9:615745. Epub 2021 Jun 4.

Univ. Littoral Côte d'Opale, Univ. Lille, Univ. Artois-ULR 7369-URePSSS-Unité de Recherche Pluridisciplinaire Sport Santé Société, Dunkirk, France.

Mandated restrictions on outdoor physical activity (PA) during the coronavirus pandemic disrupted the lifeworld of millions of people and led to a contradictory situation. On the one hand, PA was perceived as risky behaviour, as it might facilitate transmission of the virus. On the other hand, while taking precautions, regular PA was an important tool to promote the population's health during the lockdown. Read More

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Self-Medication Practices and Associated Factors in the Prevention and/or Treatment of COVID-19 Virus: A Population-Based Survey in Nigeria.

Front Public Health 2021;9:606801. Epub 2021 Jun 4.

Department of Mathematics, Physics and Electrical Engineering, Northumbria University, Newcastle upon Tyne, United Kingdom.

The anxiety caused by the emergence of the novel coronavirus disease (COVID-19) globally has made many Nigerians resort to self-medication for purported protection against the disease, amid fear of contracting it from health workers and hospital environments. Therefore, this study aimed to estimate the knowledge level, causes, prevalence, and determinants of self-medication practices for the prevention and/or treatment of COVID-19 in Nigeria. A web-based cross-sectional survey was conducted between June and July 2020 among the Nigerian population, using a self-reported questionnaire. Read More

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One-Year Update on Salivary Diagnostic of COVID-19.

Front Public Health 2021 21;9:589564. Epub 2021 May 21.

Innovation Center in Salivary Diagnostic and Nanotheranostics, Department of Physiology, Institute of Biomedical Sciences, Federal University of Uberlandia, Uberlandia, Brazil.

Coronavirus disease 2019 (COVID-19) is a global health problem, which is challenging healthcare worldwide. In this critical review, we discussed the advantages and limitations in the implementation of salivary diagnostic platforms of COVID-19. The diagnostic test of COVID-19 by invasive nasopharyngeal collection is uncomfortable for patients and requires specialized training of healthcare professionals in order to obtain an appropriate collection of samples. Read More

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Symptoms of Depression and Anxiety During the Early Phase of the COVID-19 Pandemic in Sweden.

Front Public Health 2021 2;9:562437. Epub 2021 Jun 2.

Department of Psychology and Social Work, Mid Sweden University, Östersund, Sweden.

In this cross-sectional study we aimed to assess symptoms of depression and anxiety at an early stage of the COVID-19 pandemic, and to explore factors predictive of these mental health outcomes. A sample of 1,503 participants, recruited from the general Swedish population, completed an online survey distributed through social media. In this sample, 22. Read More

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The East-West Divide in Response to COVID-19.

Engineering (Beijing) 2021 Jun 12. Epub 2021 Jun 12.

Independent consultant, Menlo Park, CA 94025, USA.

Coronavirus disease 2019 (COVID-19) death rates in the countries of the West exceed those in the countries of the East by factors ranging from 10-1 to 100-1. In this paper, we refer to the West as represented by United States plus the five most populous countries of Western Europe, and the East as the 15 countries of East Asia and Oceania that are members of the Regional Comprehensive Economic Partnership (RCEP). This paper argues that the currently available information points to the factors most responsible for this divide. Read More

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Discovery of New Potent anti-MERS CoV Fusion Inhibitors.

Front Pharmacol 2021 2;12:685161. Epub 2021 Jun 2.

Division of Cellular and Molecular Biology, Department of Cancer Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.

Middle East respiratory syndrome coronavirus (MERS-CoV), capable of zoonotic transmission, has been associated with emerging viral pneumonia in humans. In this study, a set of highly potent peptides were designed to prevent MERS-CoV fusion through competition with heptad repeat domain 2 (HR2) at its HR1 binding site. We designed eleven peptides with stronger estimated HR1 binding affinities than the wild-type peptide to prevent viral fusion with the cell membrane. Read More

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Liver injury, SARS-COV-2 infection and COVID-19: What physicians should really know?

GastroHep 2021 May 3;3(3):121-130. Epub 2021 May 3.

Internal Medicine & Hepatology Section Department of Health Promotion Sciences, Maternal and Infant Care Internal Medicine and Medical Specialties PROMISE University of Palermo School of Medicine Palermo Italy.

Background & Aims: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for coronavirus disease 2019 (COVID-19), which in males, especially in advanced age, can sometimes evolve into acute respiratory distress syndrome. In addition, mild to moderate alterations in liver function tests (LFTs) have been reported in the worst affected patients. Our review aims to analyse data on the incidence and prognostic value of LFT alterations, the underlying mechanisms and the management of pre-existing liver disease in COVID-19 affected patients. Read More

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