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Huan Jing Ke Xue 2022 Jun;43(6):2996-3004

State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China.

The seasonal variation and spatial distribution of pharmaceuticals in typical drinking water sources in the middle reaches of the Yangtze River were analyzed using the solid-phase extraction and high-performance liquid chromatography-tandem mass spectrometry methods. Combined with the risk entropy method, the corresponding ecological risks for aquatic organisms were evaluated. The results showed that 80% of the target pharmaceuticals were detected in the drinking water sources, with average concentrations of 0. Read More

J Clin Tuberc Other Mycobact Dis 2022 Aug 18;28:100318. Epub 2022 May 18.

Department of Internal Medicine, Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan.

A previously healthy 13-year-old Japanese girl with a BCG vaccination history and no tuberculosis (TB) exposure history presented to the hospital with mild dyspnea for 1 month and fever for 5 days. Computed tomography showed consolidation with a pleural effusion, obstructed left main bronchus with an air bronchogram, and traction bronchiectasis of the left upper lobe (Fig. 1A, B). Read More

Metabolites 2022 May 6;12(5). Epub 2022 May 6.

Core Facility Metabolomics, Research Institute for Farm Animal Biology (FBN), Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany.

spp. cause Legionnaires' disease with pneumonia as the predominant clinical symptom. is the second most prevalent causative agent of community-acquired pneumonia after . Read More

Cureus 2022 Apr 17;14(4):e24201. Epub 2022 Apr 17.

Department of Critical Care Medicine, Health of Science Ankara City Hospital, Ankara, TUR.

Background and aims Pregnant women are one of the vulnerable groups affected by COVID-19. With the mutation of the virus, the severity of the disease in this vulnerable group may vary in different waves of COVID-19 subtypes. The aim of this study is to define the demographic, clinical, laboratory, and mortality results of pregnant COVID-19 patients according to three time frames (March to December 2020, January to June 2021, and July to November 2021). Read More

Sci Rep 2022 04 21;12(1):6580. Epub 2022 Apr 21.

Department of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge, CB3 0AS, UK.

The development of effective pathogen reduction strategies is required due to the rise in antibiotic-resistant bacteria and zoonotic viral pandemics. Photodynamic inactivation (PDI) of bacteria and viruses is a potent reduction strategy that bypasses typical resistance mechanisms. Naturally occurring riboflavin has been widely used in PDI applications due to efficient light-induced reactive oxygen species (ROS) release. Read More

Biosens Bioelectron 2022 Aug 6;209:114165. Epub 2022 Apr 6.

Department of Chemistry ''Giacomo Ciamician'', University of Bologna, Via Selmi 2, 40126, Bologna, Italy; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres, 31, 98168, Messina, Italy; Institute for Microelectronics and Microsystems, Consiglio Nazionale delle Ricerche (CNR-IMM), Ottava Strada n.5, I-95121 Catania, Italy. Electronic address:

Detection of nucleic acids is crucial in many medical applications, and in particular for monitoring infectious diseases, as it has become perfectly clear after the pandemic infection of COVID-19. In this context, the development of innovative detection methods based on signal-amplification rather than analyte-amplification represents a significant breakthrough compared to existing PCR-based methodologies, allowing the development of new nucleic acid detection technologies suitable to be integrated in portable and low-cost sensor devices while keeping high sensitivities, thus enabling massive diagnostic screening. In this work, we present a novel molecular sensor for the ultrasensitive PCR-free detection of Hepatitis B Virus (HBV) based on electrochemiluminescence (ECL). Read More

Sci Total Environ 2022 Aug 6;832:155090. Epub 2022 Apr 6.

College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China; Zhejiang Provincial Key Laboratory of Organic Pollution Process and Control, Hangzhou 310058, China. Electronic address:

The usage of quaternary ammonium compounds (QACs) as disinfectants has increased dramatically since the outbreak of COVID-19 pandemic, leading to potentially accelerated emergence of antibiotic resistance. Long-term exposure to subinhibitory level QACs can lead to multidrug resistance, but the contribution of mutagenesis to resistance evolution is obscure. In this study, we subcultured E. Read More

Case Rep Pediatr 2022 29;2022:8984170. Epub 2022 Mar 29.

Wake Forest School of Medicine, Department of Pediatrics, 1 Medical Center Boulevard, Winston-Salem, NC 27157, USA.

Empyema necessitans is an exceptionally rare complication of bacterial pneumonia in the pediatric population. It occurs when the infection extends from the lung parenchyma to the chest wall by forming a fistula, which leads to infection of the surrounding soft tissue. In this case, a 13-year-old boy is found to have empyema necessitans caused by , with a preceding clue to the diagnosis being that he was treated for a superficial chest wall abscess several weeks prior to developing significant respiratory symptoms. Read More

Front Cell Infect Microbiol 2022 23;12:784130. Epub 2022 Feb 23.

Division of Clinical Microbiology, Department of Laboratory Medicine, Amin Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.

Data on the prevalence of bacterial co-infections and secondary infection among adults with COVID-19 admitted to the intensive care unit (ICU) are rare. We aimed to determine the frequency of secondary bacterial infection, antibiotic use, and clinical characteristics in patients admitted to the ICU with severe SARS-CoV-2 pneumonia. This was a retrospective cohort study of adults with severe COVID-19 admitted to two ICUs from March 6 to September 7, 2020 in an academic medical center in Isfahan, Iran. Read More

J Med Microbiol 2022 Mar;71(3)

Department of Infectious Disease, Section of Paediatric Infectious Disease, Imperial College London, St Mary's Campus, London, W2 1PG, UK.

The Gram-negative bacterium is the causative agent of pleuropneumonia in pigs, its only known natural host. Typical symptoms of peracute disease include fever, apathy and anorexia, and time from infection to death may only be 6 h. Severe lung lesions result from presence of one or two of the ApxI-III toxins. Read More

Ethiop J Health Sci 2022 Jan;32(1):205-208

Division of Pulmonary and Critical Care Medicine, School of Medicine, Addis Ababa University, Addis Ababa, Ethiopia.

Background: Since the outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV2) in December 2019, there have been some case reports of Coronavirus disease 19 (COVID 19) associated Guillain-Barré Syndrome (GBS). GBS is an inflammatory polyradiculoneuropathy associated with numerous viral and bacterial infections. Here we describe the case of an Ethiopian man with a typical clinical and electrophysiological manifestation of GBS. Read More

Front Med (Lausanne) 2022 9;9:814952. Epub 2022 Feb 9.

Heart Transplant Program, Division of Cardiology, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil.

Purpose: The coronavirus-2019 (COVID-19) infection is associated with a high risk of complications and death among heart transplant recipients. However, most cohorts are from high-income countries, while data from Latin America are sparse.

Methods: This is a retrospective cohort of heart transplant recipients followed at a hospital in Rio Grande do Sul, Brazil, between March 1st 2020 and October 1st 2021. Read More

Commun Dis Intell (2018) 2022 Feb 16;46. Epub 2022 Feb 16.

National Antimicrobial Utilisation Surveillance Program.

Background: Concerns have been raised internationally, regarding possible increased antimicrobial use during the COVID-19 pandemic and the potential impact on antimicrobial resistance. This analysis aimed to investigate hospital usage rates of broad-spectrum antibacterial agents used to treat community-acquired pneumonia (CAP) and/or hospital-acquired pneumonia (HAP) in Australian principal referral hospitals during 2020. Secondly, usage rates in Victoria were compared with equivalent national rates. Read More

Arch Razi Inst 2021 10 31;76(4):1005-1012. Epub 2021 Oct 31.

Belgorod State University, 308015, Russia, Belgorod, Pobeda St. 85.

The soft and delicate tissue of the brain, which is the center of our coordination, is protected by its surrounding layers. The disruption of these layers results in complicated situations and serious health problems. The brain has three protective layers of bone or skull tissue, the blood tissue layer, and finally the meningeal layer. Read More

Adv Protein Chem Struct Biol 2022 11;128:289-324. Epub 2021 Oct 11.

INSERM UMR_S 1072, Marseille, France; Aix-Marseille Université, Marseille, France. Electronic address:

Gangliosides are anionic lipids that form condensed membrane clusters (lipid rafts) and exert major regulatory functions on a wide range of proteins. In this review, we propose a new view of the structural features of gangliosides with special emphasis on emerging properties associated with protein binding modes. We analyze the different possibilities of molecular associations of gangliosides in lipid rafts and the role of cholesterol in this organization. Read More

Acta Dermatovenerol Croat 2021 Dec;29(3):164-166

Jing Liu, MD, Huaibei People's Hospital (The Huaibei Clinical College of Xuzhou Medical University), Huaibei City, China;

A male infant was born by spontaneous delivery on February 7, 2020, with a gestational age of 40 weeks and a birth weight of 4.1 kg. After birth, the infant presented with appearance of skin loss on the bilateral lower limbs, feet, left wrist, face, and lips. Read More

Viruses 2021 12 15;13(12). Epub 2021 Dec 15.

Centre for Inflammation Research, The Queen's Medical Research Institute, The University of Edinburgh, Edinburgh BioQuarter, Edinburgh EH16 4TJ, UK.

Influenza A viruses (IAVs) are important respiratory pathogens of horses and humans. Infected individuals develop typical respiratory disorders associated with the death of airway epithelial cells (AECs) in infected areas. Virulence and risk of secondary bacterial infections vary among IAV strains. Read More

Microorganisms 2021 Nov 30;9(12). Epub 2021 Nov 30.

Adelson School of Medicine, Ariel University, Ariel 4077625, Israel.

Background: The role of bacterial co-infection and superinfection among critically ill COVID-19 patients remains unclear. The aim of this study was to assess the rates and characteristics of pulmonary infections, and associated outcomes of ventilated patients in our facility.

Methods: This was a retrospective study of ventilated COVID-19 patients between March 2020 and March 2021 that underwent BioFire, FilmArray Pneumonia Panel, testing. Read More

Infect Dis Now 2022 Jun 9;52(4):208-213. Epub 2021 Dec 9.

Infectious and tropical diseases department, Bichat Hospital, Paris, France.

Objectives: During the COVID-19 pandemic, antibiotic use was very common. However, bacterial co-/secondary infections with coronaviruses remain largely unknown in standard wards. We aimed to investigate the characteristics of pulmonary bacterial infections associated with COVID-19 in hospitalized patients. Read More

Chest 2022 05 25;161(5):1180-1191. Epub 2021 Nov 25.

Division of Molecular and Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland, United Kingdom. Electronic address:

Background: Nontuberculous mycobacterial (NTM) infections are difficult to diagnose and treat. Biomarkers to identify patients with active infection or at risk of disease progression would have clinical utility. Sputum is the most frequently used matrix for the diagnosis of NTM lung disease. Read More

J Med Microbiol 2021 Nov;70(11)

Department of Respiratory Medicine, The First People's Hospital of Changde City, Hunan, PR China.

is an important cause of community-acquired pneumonia (CAP). The spectrum of CAP due to ranges from mild, self-limited to acute respiratory failure and the early identification of this disease can be challenging. Metagenomic next-generation sequencing (mNGS) of bronchoalveolar lavage fluid has the potential to improve the pathogen identification in severe CAP. Read More

Chin J Traumatol 2022 Jan 15;25(1):17-24. Epub 2021 Nov 15.

Department of Critical Care Medicine, General Hospital of Southern Theater Command of PLA, Guangzhou, 510010, China. Electronic address:

Purpose: COVID-19 is also referred to as a typical viral septic pulmonary infection by 2019-nCoV. However, little is known regarding its characteristics in terms of systemic inflammation and organ injury, especially compared with classical bacterial sepsis. This article aims to investigate the clinical characteristics and prognosis between COVID-19-associated sepsis and classic bacterial-induced sepsis. Read More

Cureus 2021 Oct 14;13(10):e18771. Epub 2021 Oct 14.

Department of General Surgery, Mohamed VI University Hospital, Faculty of Medicine and Pharmacy, Labarotory of Anatomy, Microsurgery and Surgery Experimental and Medical Simulation, Mohammed First University, Oujda, MAR.

Diffuse large B-cell lymphoma (DLBCL) is one of the most common non-Hodgkin lymphomas. It has no typical or specific clinical features. DLBCL revealed by an abscess is a rare entity. Read More

Am J Trop Med Hyg 2021 11 15;106(1):60-61. Epub 2021 Nov 15.

Department of Internal Medicine, Tripler Army Medical Center, Honolulu, Hawaii.

Shewanella algae is a gram-negative, nonfermenting, oxidase-positive, motile bacillus that is ubiquitous in aquatic ecosystems. Human infections are rare and the immunocompromised are left most vulnerable. Risk factors for this infection include exposure to seawater, consumption of raw seafood, and underlying comorbid conditions such as hepatobiliary disease and chronic cutaneous ulcers. Read More

Braz J Microbiol 2022 Mar 15;53(1):433-446. Epub 2021 Nov 15.

National Institute of Science and Technology of Dairy Production Chain (INCT-Leite), Universidade Estadual de Londrina, Paraná, Brazil.

Sheep-associated malignant catarrhal fever (SA-MCF) is a severe, frequently fatal, lymphoproliferative disease that affects a wide variety of ruminants and is caused by ovine gammaherpesvirus 2 (OvHV-2), a member of the MCF virus (MCFV) complex. The typical clinical manifestations of SA-MCF are well known and easily recognized by veterinarians, resulting in clinical diagnosis of MCF when characteristic clinical signs are present. This article describes the findings observed in cattle infected with OvHV-2 but without typical clinical manifestations of SA-MCF. Read More

Respir Investig 2022 Jan 5;60(1):56-67. Epub 2021 Nov 5.

First Department of Internal Medicine, Division of Respiratory Medicine, Infectious Disease and Allergology, Kansai Medical University, 2-3-1 Shin-machi, Hirakata, Osaka, 573-1191, Japan. Electronic address:

Atypical pneumonia is caused by atypical pathogens that are not detectable with Gram stain and cannot be cultured using standard methods. The most common causative organisms of atypical pneumonia are Mycoplasma pneumoniae, Chlamydia pneumoniae, and Legionella species. The therapeutic approach for atypical pneumonias is different than that for typical pneumonia. Read More

Sci Total Environ 2022 Feb 2;806(Pt 3):151355. Epub 2021 Nov 2.

Department of Microbiology and Biomonitoring, Faculty of Agriculture and Economics, University of Agriculture in Kraków, Adam Mickiewicz Ave. 24/28, 30-059 Kraków, Poland.

Mountain areas in Poland are among the most frequented tourist destinations and such intensive tourism negatively affects the natural environment. The COVID-19 pandemic and the resulting lockdown restricted travel for a few months in 2020, providing a unique opportunity to observe the studied mountain environment without the impact of typical tourist traffic. This study is based on the determination of antibiotic content, hydrochemical parameters, enumeration of culturable bacterial water quality indicators, antimicrobial susceptibility tests together with extended spectrum beta-lactamase (ESBL) gene detection in waterborne E. Read More

Curr Opin Ophthalmol 2022 Jan;33(1):28-34

Department of Ophthalmology, Wake Forest Baptist Health, Wake Forest University, USA.

Purpose Of Review: Endophthamitis following intraocular surgery is rare using current antiseptic techniques, such as single application of 5% povidone-iodine to the ocular surface and adjuvant topical or intracameral antibiotics. Challenges remain, however, including increased multidrug-resistant bacterial endophthalmitis, increased fungal endophthalmitis, and the low but nonzero endophthalmitis rate attributable to the typical bacteria that colonize the ocular surface.

Recent Findings: Povidone-iodine has a wide spectrum of activity, including activity against novel pathogens, such as SARS-CoV-2. Read More

Elife 2021 10 25;10. Epub 2021 Oct 25.

Division of Cancer Cell Biology, Research Institute for Biomedical Sciences (RIBS), Tokyo University of Science, Noda, Japan.

Antigens (Ags) with multivalent and repetitive structure elicit IgG production in a T-cell-independent manner. However, the mechanisms by which such T-cell-independent type-2 (TI-2) Ags induce IgG responses remain obscure. Here, we report that B-cell receptor (BCR) engagement with a TI-2 Ag but not with a T-cell-dependent (TD) Ag was able to induce the transcription of encoding activation-induced cytidine deaminase (AID) and efficient class switching to IgG3 upon costimulation with IL-1 or IFN-α in mouse B cells. Read More

BMJ 2021 10 22;375:e064132. Epub 2021 Oct 22.

Family Advisory Forum, Montreal Children's Hospital, Montreal, Quebec, Canada.