10,466 results match your criteria Pneumonia Pediatric


Incidence of community acquired pneumonia in children aged 2-59 months of age in Uttar Pradesh and Bihar, India, in 2016: An indirect estimation.

PLoS One 2019 20;14(3):e0214086. Epub 2019 Mar 20.

Department of Pediatrics, King George's Medical University, Lucknow, Uttar Pradesh, India.

Introduction: Community Acquired Pneumonia (CAP) is the leading cause of mortality in children younger than five years of age in developing countries, including India. Hence, this prospective study was performed to estimate the incidence of CAP in children (2-59 months)in four districts of Northern India.

Methods: A cross-sectional survey in rural Lucknow was conducted using cluster sampling technique to assess the proportion of CAP cases that were hospitalized in last 12 months (hospitalization fraction). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214086PLOS

Scimitar syndrome: A rare case of recurrent pneumonia.

J Pak Med Assoc 2019 Mar;69(3):423-425

Consultant Pediatrics Cardiologist, Shifa International Hospital, Islamabad.

Scimitar syndrome is a rare, congenital malformation. It is characterized by partial anomalous pulmonary venous connection to inferior vena cava, hypoplastic right lung along with dextroposition of the heart. Depending on the severity of the defect it can present as early as in neonatal period or incidentally later in life. Read More

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Isolated Cystic Lung Disease: An Algorithmic Approach to Distinguishing Birt-Hogg-Dubé Syndrome, Lymphangioleiomyomatosis, and Lymphocytic Interstitial Pneumonia.

AJR Am J Roentgenol 2019 Mar 19:1-5. Epub 2019 Mar 19.

1 Department of Radiology, National Jewish Health, Denver, CO.

Objective: Birt-Hogg-Dubé (BHD) syndrome, lymphangioleiomyomatosis (LAM), and lymphocytic interstitial pneumonia (LIP) frequently present as isolated cystic lung disease and can be challenging to distinguish. If imaging findings are otherwise unremarkable, the radiologist is unaided by ancillary CT findings in narrowing the diagnosis. We hypothesized that the distribution and morphologic features of lung cysts could be used to differentiate BHD syndrome, LAM, and LIP. Read More

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http://dx.doi.org/10.2214/AJR.18.20920DOI Listing

Identification of evolutionarily conserved virulence factor by selective pressure analysis of .

Commun Biol 2019 8;2:96. Epub 2019 Mar 8.

1Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita, Osaka 565-0871 Japan.

Evolutionarily conserved virulence factors can be candidate therapeutic targets or vaccine antigens. Here, we investigated the evolutionary selective pressures on 16 pneumococcal choline-binding cell-surface proteins since is one of the pathogens posing the greatest threats to human health. Phylogenetic and molecular analyses revealed that had the highest codon rates to total numbers of codons under considerable negative selection among those examined. Read More

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http://dx.doi.org/10.1038/s42003-019-0340-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408437PMC

Pediatric meningitis due to and Group B Streptococcus in Tijuana, Mexico: active/prospective surveillance, 2005-2018.

Ther Adv Infect Dis 2019 Jan-Dec;6:2049936119832274. Epub 2019 Mar 11.

Autonomous University of Baja-California, Campus ECISALUD, Tijuana, Baja-California, Mexico.

Introduction: In Mexico, is considered to be a rare cause of bacterial meningitis (BM), however, one national publication using active surveillance has suggested the opposite. Group B Streptococcus (GBS) is also considered to be infrequent in young infants as a cause of BM in central Mexico. vaccination using the 13-valent conjugate vaccine (PCV13) started in our region in May 2012. Read More

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http://dx.doi.org/10.1177/2049936119832274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413420PMC

Rapid pleural effusion after discontinuation of lenvatinib in a patient with pleural metastasis from thyroid cancer.

Endocrinol Diabetes Metab Case Rep 2019 Mar 18;2019. Epub 2019 Mar 18.

Department of Neurology, Respirology, Endocrinology and Metabolism, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.

We report a case of rapid pleural effusion after discontinuation of lenvatinib. A 73-year-old woman was diagnosed with poorly differentiated thyroid cancer with right pleural metastasis. Weekly paclitaxel treatment was performed for 18 weeks, but it was not effective. Read More

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http://dx.doi.org/10.1530/EDM-18-0158DOI Listing
March 2019
1 Read

Timing of Tracheostomy Placement among Children with Severe Traumatic Brain Injury: A Propensity-Matched Analysis.

J Trauma Acute Care Surg 2019 Mar 13. Epub 2019 Mar 13.

Division of Pediatric General Surgery, UCSF Benioff Children's Hospital Oakland, Oakland, CA.

Background: Early tracheostomy has been associated with shorter hospital stay and fewer complications in adult trauma patients. Guidelines for tracheostomy have not been established for children with severe TBI. The purpose of this study was to 1) define nationwide trends in time to extubation and time to tracheostomy; and 2) determine if early tracheostomy is associated with decreased length of stay and fewer complications in children with severe TBI. Read More

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http://dx.doi.org/10.1097/TA.0000000000002237DOI Listing
March 2019
5 Reads

Comorbidity Index as a Predictor of Mortality in Pediatric Patients With Solid Tumors.

Front Pediatr 2019 1;7:48. Epub 2019 Mar 1.

Epidemiological Surveillance Unit, National Institute of Respiratory Diseases, Mexico City, Mexico.

The objective of this study was to determine whether a comorbidity index could be used to predict mortality in pediatric patients with chemotherapy-treated solid tumors. Pediatric patients who underwent chemotherapy treatment for solid tumors were included, and demographic, clinical, and comorbidity data were obtained from patient electronic records. A total of 196 pediatric patients with embryonic solid tumors were included. Read More

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http://dx.doi.org/10.3389/fped.2019.00048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405632PMC

Risk Factors for Complications in Children with Staphylococcus aureus Bacteremia.

J Pediatr 2019 Mar 14. Epub 2019 Mar 14.

Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA.

Objectives: To determine risk factors for complications in children with Staphylococcus aureus (S aureus) bacteremia, including methicillin resistance.

Study Design: Single center, retrospective cohort study of children ≤18 years of age hospitalized with S aureus bacteremia. We compared clinical characteristics and outcomes between those with methicillin-sensitive S aureus (MSSA) and methicillin-resistant S aureus (MRSA) bacteremia. Read More

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http://dx.doi.org/10.1016/j.jpeds.2018.12.002DOI Listing

Successful Treatment of Recurrent Focal Segmental Glomerulosclerosis After Transplantation in Children: A Single-Center Experience.

Transplant Proc 2019 Mar 4;51(2):517-521. Epub 2019 Jan 4.

Organ Transplant Center, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia.

Objective: We aim to report our experience managing cases of recurrent focal segmental glomerulosclerosis (FSGS) in a group of pediatric renal transplant recipients.

Methods: This study was a retrospective chart review of pediatric patients who had their first kidney transplant at King Faisal Specialist Hospital & Research Center between 2014 and 2016.

Results: We reviewed the files of 6 patients, 3 of whom were male. Read More

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http://dx.doi.org/10.1016/j.transproceed.2019.01.004DOI Listing

Colonization and Infection With Extensively Drug Resistant Gram-Negative Bacteria in Liver Transplant Recipients.

Transplant Proc 2019 Mar 28;51(2):454-456. Epub 2019 Jan 28.

Intensive Care Unit, Hippokratio General Hospital, Thessaloniki, Greece.

Background: Infections due to extensively drug resistant Gram-negative bacteria (GNB) after solid organ transplantation are increasing in prevalence and are associated with high morbidity and mortality. Surveillance culture (SC) seems to be an important tool for extensively drug resistant GNB control. The aim of this study was to evaluate colonization rates and subsequent infections by XDR-GNB in liver transplant recipients. Read More

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http://dx.doi.org/10.1016/j.transproceed.2019.01.076DOI Listing

Epidemiology and mechanism of drug resistance of Mycoplasma pneumoniae in Beijing, China: A multi-center study.

Bosn J Basic Med Sci 2019 Mar 17. Epub 2019 Mar 17.

Beijing Key Laboratory for Research on Prevention and Treatment of Tropical Diseases, Beijing Tropical Medicine Research Institute, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Mycoplasma pneumoniae (M. pneumoniae) is one of the most common causes of community-acquired respiratory tract infections (RTIs). We aimed to investigate the prevalence of M. Read More

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http://dx.doi.org/10.17305/bjbms.2019.4053DOI Listing

Clinical predictors of mortality of Middle East Respiratory Syndrome (MERS) infection: A cohort study.

Travel Med Infect Dis 2019 Mar 11. Epub 2019 Mar 11.

College of Medicine, Alfaisal University, Riyadh, Saudi Arabia; Infectious Diseases Division, Department of Medicine, Department of Research, Prince Mohamed Bin Abdulaziz Hospital (?PMAH?), Ministry of Health, Riyadh, Saudi Arabia; Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA. Electronic address:

Background: Since the emergence of the Middle East Respiratory Syndrome (MERS) in 2012, the virus had caused a high case fatality rate. The clinical presentation of MERS varied from asymptomatic to severe bilateral pneumonia, depending on the case definition and surveillance strategies. There are few studies examining the mortality predictors in this disease. Read More

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http://dx.doi.org/10.1016/j.tmaid.2019.03.004DOI Listing
March 2019
1 Read

Changes in invasive pneumococcal disease spectrum after 13 valent pneumococcal conjugate vaccine implementation.

Clin Infect Dis 2019 Mar 14. Epub 2019 Mar 14.

ACTIV, Association Clinique et Thérapeutique Infantile du Val-de-Marne, Saint Maur-des-Fossés, France.

Background: Pneumococcal conjugate vaccine (PCV) implementation has led to a sharp decrease in invasive pneumococcal disease (IPD) due to the reduction in PCV serotypes (VTs). We aimed to describe the changes in the spectrum of IPD and its clinical presentations after PCV13 implementation.

Methods: This prospective, hospital-based, active surveillance involved 130 pediatric wards and microbiology departments throughout France. Read More

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http://dx.doi.org/10.1093/cid/ciz221DOI Listing
March 2019
1 Read

[Bullous pneumonia secondary to Elizabethkingia meningoseptica, its clinical and radiological evolution].

Arch Argent Pediatr 2019 Apr;117(2):e150-e154

Servicio de Neumonología, Hospital de Pediatría "Prof. Dr. Juan P. Garrahan", Ciudad Autónoma de Buenos Aires, Argentina.

Elizabethkingia meningoseptica is an opportunistic pathogen with a high mortality and an increasing incidence in the intensive care units. We present a 4-year-old patient with a history of atresia of the biliary tract and a liver transplant at 11 months of age, who was admitted for acute respiratory infection with hypoxemia. During the hospitalization, she required mechanical ventilation. Read More

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http://dx.doi.org/10.5546/aap.2019.e150DOI Listing
April 2019
1 Read

Prevalence of extubation and associated risk factors at a tertiary care pediatric intensive care unit.

Arch Argent Pediatr 2019 Apr;117(2):87-93

Hospital de Pediatría SAMIC "Prof. Dr. Juan P. Garrahan", Ciudad Autónoma de Buenos Aires, Argentina.

Introduction: Extubation failure (EF) is associated with a higher risk for pneumonia, hospital stay, and mortality.

Objective: To determine the prevalence of EF and identify the associated factors in our population.

Materials And Methods: Observational and retrospective design. Read More

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http://dx.doi.org/10.5546/aap.2019.eng.87DOI Listing
April 2019
1 Read

Common alternative diagnoses among a pediatric hospital-based cohort evaluated for tuberculosis in Karachi, Pakistan: The need for facilitated referral in tuberculosis clinics.

Int J Mycobacteriol 2019 Jan-Mar;8(1):42-47

Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan; Faculty of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, London WCIE 7HT, England, UK.

Background: Children evaluated for tuberculosis (TB) are often diagnosed with miscellaneous conditions that mimic TB. Knowledge of differentials informs policy on service provision through liaison with referral centers offering definitive diagnosis and treatment for common alternative disorders.

Methods: We reviewed medical records of children who were offered diagnostic testing for TB (culture or Xpert MTB/RIF) at a tertiary care hospital in Karachi, Pakistan to identify common alternative diagnoses among children who are evaluated for TB. Read More

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http://dx.doi.org/10.4103/ijmy.ijmy_8_19DOI Listing
March 2019
1 Read

The Mortality and the Risk of Aspiration Pneumonia Related with Dysphagia in Stroke Patients.

J Stroke Cerebrovasc Dis 2019 Mar 8. Epub 2019 Mar 8.

Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Pediatrics, Faculty of Pediatrics, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Pediatrics, Kaohsiung Municipal Siaogang Hospital, Kaohsiung, Taiwan; Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address:

Background: Dysphagia may result in poor outcomes in stroke patients due to aspiration pneumonia and malnutrition.

Goal: The aim of the study was to investigate aspiration pneumonia and the mortality rate in stroke patients with dysphagia in Taiwan.

Methods: We selected 1220 stroke patients, divided them into dysphagia and nondysphagia groups, and matched them according to age; covariates and comediations from 2000 to 2005 were identified from the NHIRD 2000 database. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10523057193005
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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.02.011DOI Listing
March 2019
2 Reads

The Impact of Molecular Testing for Pathogens of Community-Acquired Pneumonia on Antibiotic Utilization.

S D Med 2019 Feb;72(2):63-66

Department of Internal Medicine, University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.

Community-acquired pneumonia (CAP) is a common and costly problem in U.S. healthcare. Read More

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February 2019
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The Value of Different Radiological Modalities in Assessment of Spontaneous Pneumomediastinum: Case Review and Diagnostic Perspective.

AJP Rep 2019 Jan 7;9(1):e72-e75. Epub 2019 Mar 7.

Department of Pediatrics, University of Saskatchewan, Saskatoon, Canada.

Pneumomediastinum (PM), or a mediastinal air leak, is a known morbidity in neonates. Among predisposing factors, the most significant are mixed lung diseases, such as pneumonia or meconium aspiration syndrome, with coexisting atelectasis and airway obstruction. We report an unusual presentation of significant spontaneous pneumomediastinum in a term newborn delivered by elective cesarean section with no history of active resuscitation at birth. Read More

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http://dx.doi.org/10.1055/s-0039-1683862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406024PMC
January 2019

Quercetin ameliorates lipopolysaccharide-caused inflammatory damage via down-regulation of miR-221 in WI-38 cells.

Exp Mol Pathol 2019 Mar 6;108:1-8. Epub 2019 Mar 6.

Children's Medical Center, The Affiliated Hospital of Qingdao University, Qingdao 266000, China.

Background: Pneumonia is a common respiratory disease in pediatrics. Quercetin is a natural flavonoid widely distributed in many foods and drinks. Herein, we focused our investigation on the possible protective activity of quercetin in lipopolysaccharide (LPS)-caused inflammatory damage of WI-38 lung fibroblasts. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00144800183055
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http://dx.doi.org/10.1016/j.yexmp.2019.03.002DOI Listing
March 2019
4 Reads

Bacteremic Community-Acquired Pneumonia in Ethiopian Children: Etiology, Antibiotic Resistance, Risk Factors, and Clinical Outcome.

Open Forum Infect Dis 2019 Mar 23;6(3):ofz029. Epub 2019 Jan 23.

Laboratory Bacteriology Research, Department of Diagnostic Sciences, Faculty of Medicine & Health Sciences, Ghent University, Ghent, Belgium.

Background: Community-acquired pneumonia (CAP) remains a leading cause of morbidity and mortality. We sought to determine the magnitude, etiology, and risk factors of CAP in children 5 years after introduction of pneumococcal conjugate vaccine (PCV) 10 in Ethiopia.

Methods: We conducted a prospective observational study on the bacterial etiology and risk factors of CAP among children aged 0-15 years in 2 pediatric emergency departments in Addis Ababa, Ethiopia. Read More

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http://dx.doi.org/10.1093/ofid/ofz029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396085PMC
March 2019
2 Reads

Mortality Predictive Scores for Community-Acquired Pneumonia in Children.

Curr Infect Dis Rep 2019 Mar 5;21(3):10. Epub 2019 Mar 5.

Institute of Tropical Medicine, Asunción, Paraguay.

Purpose Of Review: The use of severity score for the staging of pneumonias has emerged as a necessity for the physician caring for this disease. Although there are several established prognostic scoring systems for community-acquired pneumonia in adults, the availability for children are scarce.

Recent Findings: Recently, scoring system for risk stratification of children with pneumonia were developed in low- and middle-income countries. Read More

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http://dx.doi.org/10.1007/s11908-019-0666-9DOI Listing
March 2019
1 Read

Considerations for Dose Selection and Clinical Pharmacokinetics/Pharmacodynamics for the Development of Antibacterial Agents.

Antimicrob Agents Chemother 2019 Mar 4. Epub 2019 Mar 4.

Albany College of Pharmacy and Health Sciences, Albany, NY, USA.

In June 2017, The National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, organized a workshop entitled "Pharmacokinetics-Pharmacodynamics (PK/PD) for Development of Therapeutics against Bacterial Pathogens" to discuss details and critical parameters of various PK/PD methods and identify approaches for linking human pharmacokinetic (PK) data and drug efficacy analyses. The workshop participants included individuals from academia, industry and government. This and the accompanying mini-review on nonclinical PK/PD summarize the workshop discussions and recommendations. Read More

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http://dx.doi.org/10.1128/AAC.02309-18DOI Listing
March 2019
2 Reads

Fiberoptic Bronchoscopic Balloon Dilatation of Bronchial Stenosis in Children.

J Bronchology Interv Pulmonol 2019 Mar 1. Epub 2019 Mar 1.

Pediatrics, Division of Cardiology, Erciyes University, Kayseri, Turkey.

Background: Bronchial stenosis and treatment with balloon dilatation are rarely experienced in children. The aim of this study was to investigate the results of fiberoptic bronchoscopic balloon dilatation (BBD) in children.

Methods: Between January 2016 and March 2018, 7 children diagnosed as having bronchial stenosis and who underwent BBD as the first treatment option were enrolled in the study. Read More

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http://dx.doi.org/10.1097/LBR.0000000000000581DOI Listing
March 2019
1 Read

Guideline Adherence in Diagnostic Testing and Treatment of Community-Acquired Pneumonia in Children.

Pediatr Emerg Care 2019 Feb 14. Epub 2019 Feb 14.

Ann and Robert H Lurie Children's Hospital, Feinberg School of Medicine, Northwestern University, Chicago, IL.

Objectives: The objective of this study was to determine emergency department (ED) physician adherence with the 2011 Pediatric Infectious Diseases Society (PIDS) and Infectious Diseases Society of America (IDSA) guidelines for outpatient management of children with mild-to-moderate community-acquired pneumonia (CAP).

Methods: A cross-sectional survey of physicians on the American Academy of Pediatrics Section on Emergency Medicine Survey listserv was conducted. We evaluated ED physicians' reported adherence with the PIDS/IDSA guidelines through presentation of 4 clinical vignettes representing mild-to-moderate CAP of presumed viral (preschool-aged child), bacterial (preschool and school-aged child), and atypical bacterial (school-aged child) etiology. Read More

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http://dx.doi.org/10.1097/PEC.0000000000001745DOI Listing
February 2019
2 Reads

Bronchodilators, Antibiotics, and Oral Corticosteroids Use in Primary Care for Children With Cough.

Glob Pediatr Health 2019 25;6:2333794X19831296. Epub 2019 Feb 25.

New York Medical College, Valhalla, NY, USA.

Real-world management decisions for acute cough in children in primary care practice are not well understood. This study is an analysis of 560 encounters for children with cough, 19 days to 18 years of age, seen in a predominantly suburban academic pediatric practice, over 1 year. Past history, cough duration, and cough characteristics significantly affected treatment decisions. Read More

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http://dx.doi.org/10.1177/2333794X19831296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390215PMC
February 2019
1 Read

Epidemiological characteristics of nasopharyngeal Streptococcus pneumoniae strains among children with pneumonia in Chongqing, China.

Sci Rep 2019 Mar 1;9(1):3324. Epub 2019 Mar 1.

Ministry of Education Key Laboratory of Child Development and Disorders; Key Laboratory of Pediatrics in Chongqing, CSTC2009CA5002; Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.

Streptococcus pneumoniae (pneumococcus) is the most common respiratory pathogen worldwide. Nasopharyngeal carriage with S. pneumoniae is the major source of lower respiratory tract infection and horizontal spread among children. Read More

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http://www.nature.com/articles/s41598-019-40088-6
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http://dx.doi.org/10.1038/s41598-019-40088-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397308PMC
March 2019
8 Reads

Effectiveness of a ventilator-associated pneumonia prevention bundle in critically ill children.

J Biol Regul Homeost Agents 2019 Mar 1;33(2). Epub 2019 Mar 1.

A. Gemelli University Hospital Foundation, School of Dental Medicine, Catholic University of the Sacred Heart, Rome.

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March 2019
4 Reads

Bronchoalveolar lavage with pediatric flexible fibreoptic bronchoscope in pediatric haematopoietic stem cell transplant patients: Nursing considerations for operative complications.

J Spec Pediatr Nurs 2019 Feb 28:e12236. Epub 2019 Feb 28.

Guangzhou Women and Children's Medical Center, Guangzhou, Guangdong, China.

Purpose: Bronchoalveolar lavage (BAL) with pediatric flexible fibreoptic bronchoscopy (FB) is used for diagnostic and therapeutic purposes in pediatric haematopoietic stem cell transplant (HSCT) patients with pulmonary complications. The aim of our study was to evaluate complications in pediatric HSCT patients undergoing BAL/FB and to explore the nursing emphases on complications.

Design And Methods: We performed a retrospective, case-controlled study to evaluate perioperative complications of HSCT children. Read More

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http://doi.wiley.com/10.1111/jspn.12236
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http://dx.doi.org/10.1111/jspn.12236DOI Listing
February 2019
5 Reads

An Infant with Interstitial Lung Disease.

Indian Pediatr 2019 Feb;56(2):135-140

Department of Histopathology; Postgraduate Institute of Medical Education and Research, Chandigarh, India. Correspondence to: Dr Uma Nahar, Professor, Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh 160 012, India.

Interstitial lung disease in infants, unlike older children and adults, has diverse etiology, including infective, metabolic, autoimmune, genetic, malignant and idiopathic causes. Clinical recognition of the interstitial pattern of lung involvement is important as the etiology and management is entirely different from that of recurrent or chronic lung parenchymal pathologies. We discuss the clinical and pathological findings of an infant with interstitial pneumonia, who succumbed to hospital-acquired sepsis. Read More

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February 2019
2 Reads

Community-acquired pneumonia in children: cell-free plasma sequencing for diagnosis and management.

Diagn Microbiol Infect Dis 2019 Feb 2. Epub 2019 Feb 2.

University of California San Diego, Department of Pediatrics, Division of Critical Care.

Community-acquired pneumonia (CAP) is a common cause of pediatric hospital admission. Empiric antibiotic therapy for hospitalized children with serious CAP now targets the most likely pathogen(s), including those that may demonstrate significant antibiotic resistance. Cell-free plasma next-generation sequencing (CFPNGS) was first made available for Pediatric Infectious Diseases physicians in June 1, 2017, to supplement standard-of-care diagnostic techniques. Read More

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http://dx.doi.org/10.1016/j.diagmicrobio.2018.12.016DOI Listing
February 2019
2 Reads

[LIG4 syndrome: a report of four cases and literature review].

Zhonghua Er Ke Za Zhi 2019 Mar;57(3):217-221

Department of Hematology, Children's Hospital, Capital Institute of Pediatrics, Beijing 100020, China.

To analyze clinical, immunological and genetic characteristics of 4 cases of LIG4 syndrome. We retrospectively analyzed the clinical data of 4 patients from 3 families with LIG4 syndrome who were admitted to Children's Hospital of the Capital Institute of Pediatrics from June 2017 to May 2018, and reviewed related articles, the clinical, immunological and genetic characteristics of LIG4 syndrome were summarized and analyzed. Those 4 cases (P1 to P4), including 2 males and 2 females, had an average age of 1. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1310.2019.03.012DOI Listing
March 2019
2 Reads

A meta-analysis of randomized controlled trials: Efficacy of selenium treatment for sepsis.

Medicine (Baltimore) 2019 Mar;98(9):e14733

Department of Emergency, Children's Hospital of Chongqing Medical University.

Background: To understand the clinical outcomes of selenium therapy in patients with sepsis syndrome, we conducted a meta-analysis of randomized controlled trials (RCT).

Methods: A total of 13 RCTs comparing selenium and placebo for patients with sepsis were reviewed systematically.

Results: However, we could not detect the association of selenium treatment with a decreased mortality at different time course (relative risk [RR] [95% confidence interval, CI]: 0. Read More

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http://dx.doi.org/10.1097/MD.0000000000014733DOI Listing
March 2019
3 Reads

Comparison of clinical characteristics of human metapneumovirus and respiratory syncytial virus infection in hospitalized young children.

Jpn J Infect Dis 2019 Feb 28. Epub 2019 Feb 28.

Department of Pediatrics, Nagoya University Graduate School of Medicine.

Human metapneumovirus (HMPV) infection and respiratory syncytial virus (RSV) infection are the leading causes of acute respiratory tract infection in children, and clinical manifestations of these virus infections are considered similar. To investigate the differences in clinical characteristics between HMPV and RSV infections in young children, we prospectively enrolled children <3 years old who required hospitalization with acute respiratory tract infection by HMPV or RSV at 10 hospitals in Japan. We enrolled 48 with HMPV infection and 141 children with RSV infection. Read More

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http://dx.doi.org/10.7883/yoken.JJID.2018.480DOI Listing
February 2019
1 Read

Mutations in the PIGW gene associated with hyperphosphatasia and mental retardation syndrome: a case report.

BMC Pediatr 2019 Feb 27;19(1):68. Epub 2019 Feb 27.

Kangso Medical Inspection, Beijing, China.

Background: Mutations in the PIGV, PIGO, PIGL, PIGY, PGAP2, PGAP3, and PIGW genes have recently been reported to cause hyperphosphatasia accompanied by mental retardation syndrome (HPMRS); the latter is an autosomal-recessive neurological disorder typically characterised by recurrent seizures, intellectual disability, and distinct facial features. Here, we report an extremely rare case of a Chinese boy with compound heterozygous PIGW mutations who suffers from severe pneumonia, mental retardation, and epilepsy.

Case Presentation: A 70-day-old boy presented with fever and cough over 20 days in duration at the time of admission. Read More

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https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887
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http://dx.doi.org/10.1186/s12887-019-1440-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394075PMC
February 2019
5 Reads

Acute fibrinous and organizing pneumonia: A case report.

Medicine (Baltimore) 2019 Feb;98(8):e14537

Department of Infectious Disease.

Rationale: Acute fibrinous and organizing pneumonia (AFOP) is an uncommon type of acute lung injury associated with infection, connective tissue disorders, drug exposure, and hematologic malignancies.

Patient Concerns: A 53-year-old female presented with intermittent fever, chills, and dry cough since 10 days. Chest computed tomography scan showed multiple bilateral patchy infiltrates. Read More

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http://dx.doi.org/10.1097/MD.0000000000014537DOI Listing
February 2019
1 Read
5.723 Impact Factor

Organizing pneumonia in a pediatric patient on minocycline: A potential culprit.

Pediatr Pulmonol 2019 Feb 27. Epub 2019 Feb 27.

Department of Pediatric Pulmonology, Cleveland Clinic Children's Hospital, Cleveland, Ohio.

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http://dx.doi.org/10.1002/ppul.24283DOI Listing
February 2019

Varicella complications in children one-site Polish population – a 19- year long survey

Przegl Epidemiol 2018 ;72(4):459-467

Department of Pediatric Infectious Diseases and Hepatology, Faculty of Medicine, Collegium Medicum Nicolaus Copernicus University

Objectives: The aim of this study was to describe the epidemiology of chickenpox complications in children, based on a 19-year long survey.

Methods: This publication constitutes a review of medical records of 761 patients under the age of 18 who were hospitalized at the T. Browicz Provincial Hospital for Infectious Diseases in Bydgoszcz, Poland from the 1st of January 1999 to the 31st of December 2017. Read More

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http://dx.doi.org/10.32394/pe.72.4.21DOI Listing
January 2018
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Identification and Containment of a Cluster of Two Infections in a Neonatal Intensive Care Unit.

Can J Infect Dis Med Microbiol 2019 20;2019:1506583. Epub 2019 Jan 20.

Div. Neonatology, University Children's Hospital and Perinatal Center, Ludwig Maximilian University Munich, Munich, Germany.

We report a cluster of invasive infections in a neonatal intensive care unit. We describe the clinical course of two infected patients, one of whom died of severe pneumonia after successfully being weaned from ECMO. Environmental analyses failed to yield a common source. Read More

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http://dx.doi.org/10.1155/2019/1506583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360598PMC
January 2019
2 Reads

Interleukin-10 produced by myeloid derived suppressor cells provides protection to Carbapenem-resistant ST258 by enhancing its clearance in the airways.

Infect Immun 2019 Feb 25. Epub 2019 Feb 25.

Millennium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago 8331010, Chile, Pontificia Universidad Católica de Chile, Chile.

Carbapenem-resistant ST258 (CRKP-ST258) can cause chronic infections in lungs and airways, with repeated episodes of bacteremia. In this report we addressed whether the recruitment of myeloid cells producing the anti-inflammatory cytokine interleukin 10 (IL-10) modulates the clearance of CKRP-ST258 in the lungs and establishes bacterial persistence. Our data demonstrate that during pneumonia caused by a clinical isolate of CRKP-ST258 (KP35) there is an early recruitment of Monocyte-Myeloid Derived Suppressor Cells (M-MDSCs) and neutrophils that actively produce IL-10. Read More

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http://dx.doi.org/10.1128/IAI.00665-18DOI Listing
February 2019
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Herbs use in Saudi children with acute respiratory illnesses.

Sudan J Paediatr 2018 ;18(2):20-24

Department of Pediatrics, College of Medicine, Majmaah University, Al Majmaah, Saudi Arabia.

The current study aims to evaluate the prevalence of the utilization of various herbal remedies in children hospitalized with lower respiratory illnesses and assess the different herbal products which are most commonly used. Moreover, the indications of usage and the route and frequency of administration are also highlighted. All children who were hospitalized in three centers, through the period of 18 months, due to acute bronchiolitis, pneumonia, or bronchial asthma were included in this study. Read More

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http://dx.doi.org/10.24911/SJP.106-1538457624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378577PMC
January 2018
2 Reads

Etiology and disposition associated with radiology discrepancies on emergency department patients.

Am J Emerg Med 2019 Feb 19. Epub 2019 Feb 19.

Department of Emergency Medicine, Department of Pediatrics, Penn State Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA. Electronic address:

Background: Diagnostic errors made by radiology resident physicians may lead to significant morbidity/mortality and patient dissatisfaction.

Objective: To determine the etiology and disposition associated with radiology discrepancies on emergency department (ED) patients.

Methods: We conducted a retrospective electronic chart review of patients presenting to our ED during "off hours" at the Penn State Hershey Medical Center during October 2013-November 2014 and had a radiology discrepancy, defined as a patient discharged from the ED with a diagnostic interpretation disagreement between the initial radiology resident physician read and final radiology attending physician read. Read More

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http://dx.doi.org/10.1016/j.ajem.2019.02.027DOI Listing
February 2019

Two pediatric cases of Pneumocystis jirovecii pneumonia diagnosed by polymerase chain reaction of gastric lavage.

J Infect Chemother 2019 Feb 21. Epub 2019 Feb 21.

Department of Pediatrics, Chiba University Graduate School of Medicine, 1-8-1 Inohana Chuo ku, Chiba City, Chiba, 260-8677, Japan.

Detecting Pneumocystis jirovecii by bronchoalveolar lavage or lung biopsy is the gold standard for diagnosis of P. jirovecii pneumonia (PJP); however, these techniques are not always applicable in children because of their high invasiveness. We report two pediatric cases of PJP diagnosed by polymerase chain reaction (PCR) of gastric lavage that were successfully treated. Read More

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http://dx.doi.org/10.1016/j.jiac.2019.01.016DOI Listing
February 2019
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Levosimendan as Rescue Therapy for Acute Heart Failure in a Patient with Duchenne Muscular Dystrophy.

Pediatr Cardiol 2019 Mar 22;40(3):668-670. Epub 2019 Feb 22.

Pediatric Intensive Care Unit, Hôpital Raymond-Poincaré, APHP, 92380, Garches, France.

The longer survival of patients with Duchenne muscular dystrophy due to advances in clinical care has increased the incidence of Duchenne muscular dystrophy-associated cardiomyopathy, a nearly consistent feature in the third decade of life. A 26-year-old patient with Duchenne muscular dystrophy experienced severe acute heart failure triggered by pneumonia. Levosimendan was effective in improving heart function. Read More

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http://link.springer.com/10.1007/s00246-019-02072-9
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http://dx.doi.org/10.1007/s00246-019-02072-9DOI Listing
March 2019
3 Reads

Hospital admissions in children with acute respiratory disease in Portugal.

Pulmonology 2019 Feb 20. Epub 2019 Feb 20.

Pediatrics Department, Santa Maria Hospital - CHLN, Lisbon Medical Academic Centre (CAML), Lisbon, Portugal.

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http://dx.doi.org/10.1016/j.pulmoe.2018.12.004DOI Listing
February 2019
2 Reads

Interrater reliability of pediatric point-of-care lung ultrasound findings.

Am J Emerg Med 2019 Feb 15. Epub 2019 Feb 15.

Division of Emergency Medicine, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA, United States of America. Electronic address:

Objective: We sought to assess interrater reliability (IRR) of lung point-of-care ultrasound (POCUS) findings among pediatric patients with suspected pneumonia.

Methods: A convenience sample of patients between the ages of 6 months and 18 years with a clinical suspicion of pneumonia had a lung ultrasound performed by a POCUS-credentialed emergency medicine physician with subsequent expert review. Each lung zone was assessed as either normal or abnormal, and specific ultrasound findings were recorded. Read More

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http://dx.doi.org/10.1016/j.ajem.2019.01.047DOI Listing
February 2019

Enhanced IL-1β production is mediated by a TLR2-MYD88-NLRP3 signaling axis during coinfection with influenza A virus and Streptococcus pneumoniae.

PLoS One 2019 22;14(2):e0212236. Epub 2019 Feb 22.

Department of Biology, Missouri State University, Springfield, Missouri, United States of America.

Viral-bacterial coinfections, such as with influenza A virus and Streptococcus pneumoniae (S.p.), are known to cause severe pneumonia. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212236PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386446PMC
February 2019
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Risk of Necrotizing Enterocolitis Following Packed Red Blood Cell Transfusion in Very Low Birth Weight Infants.

Indian J Pediatr 2019 Feb 21. Epub 2019 Feb 21.

The Epidemiology Unit, Faculty of Medicine, Prince of Songkla University, Hat Yai District, Songkhla, Thailand.

Objective: To evaluate the association between red blood cell (RBC) transfusion leading to necrotizing enterocolitis (NEC) within 48 h, known as transfusion-associated necrotizing enterocolitis (TANEC).

Methods: A nested case-control study using historical data was conducted in the neonatal intensive care unit of Songklanagarind Hospital, Thailand. All very low birth weight (VLBW) infants delivered between November 2009 and July 2016 were enrolled. Read More

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http://dx.doi.org/10.1007/s12098-019-02887-7DOI Listing
February 2019
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Epidemiological and clinical features of invasive pneumococcal disease caused by serotype 12F in adults, Japan.

PLoS One 2019 21;14(2):e0212418. Epub 2019 Feb 21.

Infectious Diseases Surveillance Center, National Institute of Infectious Diseases, Tokyo, Japan.

Enhanced surveillance of invasive pneumococcal disease (IPD) in adults was conducted during April 2013-March 2018 in 10 of 47 prefectures in Japan, and a total of 1277 IPD patients were enrolled. An emergence of IPD caused by serotype 12F was identified during May 2015-March 2018 through this surveillance. 12F isolates were composed of four related sequence types. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212418PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383924PMC
February 2019
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