25,369 results match your criteria Pneumonia Pediatric

Three Exposure Metrics for Fine Particulate Matter Associated With Outpatient Visits for Acute Lower Respiratory Infection Among Children in Guangzhou, China.

Front Public Health 2022 9;10:876496. Epub 2022 Jun 9.

Department of Pediatrics, Guangdong Second Provincial General Hospital, Guangzhou, China.

Ambient fine particulate matter (PM) is associated with an elevated risk of acute lower respiratory infections (ALRI). However, this association has not been examined using alternative exposure metrics. We collected outpatient data of patients with ALRI aged <14 years from the administrative database of a large tertiary hospital in Guangzhou, China, from 2013 to 2019. Read More

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Magnitude of tuberculosis and its associated factors among under-five children admitted with severe acute malnutrition to public hospitals in the city of Dire Dawa, Eastern Ethiopia, 2021: multi-center cross-sectional study.

IJID Reg 2022 Jun 28;3:256-260. Epub 2022 Apr 28.

Department of Pediatrics and Child Health Nursing, School of Nursing, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Objective: The aim of this study was to assess the prevalence of tuberculosis (TB) and its associated factors among children under 5 years of age with severe acute malnutrition.

Methods: A multi-center, institution-based, retrospective cross-sectional study was conducted at public hospitals in Dire Dawa City Administration, Eastern Ethiopia from January 1, 2018 to December 30, 2020. A binary logistic regression model was fitted to identify factors associated with the prevalence of TB. Read More

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Comparison of pneumonia features in children caused by SARS-CoV-2 and other viral respiratory pathogens.

Pediatr Pulmonol 2022 Jun 26. Epub 2022 Jun 26.

Pediatrics Department. Hospital Universitario Infanta Sofía. Pediatrics Research Group. Universidad Europea de Madrid, Spain. Pediatric Research and Clinical Trials Unit (UPIC). Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain. Fundación de Investigación Biomédica Hospital 12 de Octubre. RITIP (Translational Research Network in Paediatric Infectious Diseases).

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ARDS clinical practice guideline 2021.

Respir Investig 2022 Jun 23. Epub 2022 Jun 23.

Department of Anesthesiology, Osaka Women's and Children's Hospital, Osaka, Japan.

Background: The joint committee of the Japanese Society of Intensive Care Medicine/Japanese Respiratory Society/Japanese Society of Respiratory Care Medicine on ARDS Clinical Practice Guideline has created and released the ARDS Clinical Practice Guideline 2021.

Methods: The 2016 edition of the Clinical Practice Guideline covered clinical questions (CQs) that targeted only adults, but the present guideline includes 15 CQs for children in addition to 46 CQs for adults. As with the previous edition, we used a systematic review method with the Grading of Recommendations Assessment Development and Evaluation (GRADE) system as well as a degree of recommendation determination method. Read More

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Burden of pneumococcal disease due to serotypes covered by the 13-valent and new higher-valent pneumococcal conjugate vaccines in the United States.

Vaccine 2022 Jun 23. Epub 2022 Jun 23.

Health Economics and Outcomes Research, Pfizer Inc, New York, NY, USA. Electronic address:

The addition of pneumococcal conjugate vaccines (PCVs) to the United States (US) national immunization program led to significant reductions in incidence, mortality, and associated sequelae caused by pneumococcal disease (PD) in children and adults through direct and indirect protection. However, there remains clinical and economic burden due to PD caused by serotypes not included in the current 13-valent PCV (PCV13) formulation. To address this unmet need, 15-valent PCV (PCV15) and 20-valent PCV (PCV20), containing additional serotypes to PCV13, were recently approved in the US for adults and are anticipated for pediatrics in the near future. Read More

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Baseline conditions and nutritional state upon hospitalization are the greatest risks for mortality for cardiovascular diseases and for several classes of diseases: a retrospective study.

Sci Rep 2022 Jun 25;12(1):10819. Epub 2022 Jun 25.

IRCCS MultiMedica, Milan, Italy.

The aim of this retrospective study was to evaluate risk factors for 3-years mortality after hospital discharge in all inpatients admitted to a general hospital in Milano, Italy. A total of 2580 consecutive patients admitted to Ospedale San Paolo, July 1 to December 31, 2012, for several classes of diseases (internal medicine, cancer, infectious diseases, trauma and surgery, pneumonia, and heart diseases) were studied. Age, total disease, type of admission, length of admission, age-adjusted Charlson index, prognostic nutritional index (PNI), and full blood count were evaluated. Read More

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Characteristics and Results of Hospital Admission Caused by Influenza Virus Infections in Children under 5 Years Old.

J Trop Pediatr 2022 Jun;68(4)

Department of Pediatric Diseases, Tepecik Training and Research Hospital, University of Health Sciences, Izmir, Turkey.

Aims: The influenza virus is an infectious disease with acute respiratory tract infections, caused secondary bacterial infections and death. In this study, we aimed to determine which predictors were associated with the need for high-flow nasal cannula oxygen therapy (HFNC) and transition to intensive care for influenza virus and also to compare single viral pathogens with multiple ones.

Methods: Inpatients under the age of 5 with influenza virus-related respiratory tract infections between November 2015 and March 2019 were included in the study. Read More

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Neonates with SARS-CoV-2 infection: spectrum of disease from a prospective nationwide observational cohort study.

Swiss Med Wkly 2022 May 27;152:w30185. Epub 2022 May 27.

Paediatrics and Paediatric Infectious Diseases, Children's Hospital Lucerne, Cantonal Hospital Lucerne, Switzerland.

Background: Coronavirus disease 2019 (COVID-19) can be more severe in infants than in older children. To date, only a few case series have reported data on neonates with COVID-19, including mostly asymptomatic neonates who were tested because of exposure to maternal SARS-CoV-2 infection. This study summarises nationwide epidemiological data, clinical characteristics, treatment and outcomes of neonates presenting with symptomatic SARS-CoV-2 infection. Read More

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Association between the COVID-19 pandemic and pertussis derived from multiple nationwide data sources, France, 2013 to 2020.

Euro Surveill 2022 Jun;27(25)

Institut Pasteur, Université Paris Cité, Biodiversity and Epidemiology of Bacterial Pathogens, Paris, France.

BackgroundInterventions to mitigate the COVID-19 pandemic may impact other respiratory diseases.AimsWe aimed to study the course of pertussis in France over an 8-year period including the beginning of the COVID-19 pandemic and its association with COVID-19 mitigation strategies, using multiple nationwide data sources and regression models.MethodsWe analysed the number of French pertussis cases between 2013 and 2020, using PCR test results from nationwide outpatient laboratories (Source 1) and a network of the paediatric wards from 41 hospitals (Source 2). Read More

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COVID-19 Lockdown Impacts Among Patients with Cystic Fibrosis: An Italian Regional Reference Centre Experience.

Front Biosci (Landmark Ed) 2022 Jun;27(6):178

Department of Maternal, Infantile and Urological Sciences, Sapienza University of Rome, 155, 00161 Rome, Italy.

Background: Coronavirus pandemic has influenced our society with social distancing and management of chronic disease such as cystic fibrosis (CF). During the Italian lockdown from March to May 2020, CF patients reduced the number of outpatient visits, limited social interactions and spent more time at home. The aim of this study is to evaluate the impact of the lockdown on body mass index (BMI) and lung function tests on CF patients. Read More

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Validation of Prediction Models for Pneumonia Among Children in the Emergency Department.

Pediatrics 2022 Jun 24. Epub 2022 Jun 24.

Division of Emergency Medicine, Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Background: Several prediction models have been reported to identify patients with radiographic pneumonia, but none have been validated or broadly implemented into practice. We evaluated 5 prediction models for radiographic pneumonia in children.

Methods: We evaluated 5 previously published prediction models for radiographic pneumonia (Neuman, Oostenbrink, Lynch, Mahabee-Gittens, and Lipsett) using data from a single-center prospective study of patients 3 months to 18 years with signs of lower respiratory tract infection. Read More

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Respiratory virus testing and clinical outcomes among children hospitalized with pneumonia.

J Hosp Med 2022 Jun 23. Epub 2022 Jun 23.

Division of Emergency Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.

Background: Despite the increased availability of diagnostic tests for respiratory viruses, their clinical utility for children with community-acquired pneumonia (CAP) remains uncertain.

Objective: To identify patterns of respiratory virus testing across children's hospitals prior to the COVID-19 pandemic and to determine whether hospital-level rates of viral testing were associated with clinical outcomes.

Design, Setting, And Participants: Multicenter retrospective cohort study of children hospitalized for CAP at 19 children's hospitals in the United States from 2010-2019. Read More

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Impact of Systemic Diseases on Olfactory Function in COVID-19 Infected Patients.

Int J Gen Med 2022 17;15:5681-5691. Epub 2022 Jun 17.

Medical Physiology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.

Background: COVID-19 (SARS-CoV-2/2019-nCoV) is now a major public health threat to the world. Olfactory dysfunctions (ODs) are considered potential indicating symptoms and early case identification triaging for coronavirus disease 2019 (COVID-19). The most common reported comorbidities are diabetes mellitus, chronic lung disease, and cardiovascular disease. Read More

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Clinical Observation of Reduning Combined with Recombinant Human Interferon -2b in the Treatment of Children with Viral Pneumonia.

Evid Based Complement Alternat Med 2022 14;2022:1739561. Epub 2022 Jun 14.

Department of Pharmacy, Cangzhou Central Hospital, Cangzhou 061000, Hebei, China.

Purpose: To observe the clinical efficacy of Reduning injection combined with recombinant human interferon -2b spray in the treatment of children with viral pneumonia.

Methods: A total of 200 children with viral pneumonia over 2 years old who were admitted to the Pediatrics Department of the Cangzhou Central Hospital from September 2018 to November 2020 were recruited and randomized into the control group and observation group at a ratio of 1 : 1, with 100 cases in each group. The children in the control group were given recombinant human interferon -2b spray, and the children in the observation group were given Reduning injection on the basis of the control group. Read More

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Nonspecific Interstitial Pneumonitis in a Child Associated With Hashimoto Thyroiditis.

Cureus 2022 Jun 18;14(6):e26072. Epub 2022 Jun 18.

Department of Pediatrics, Al Qassimi Women's and Children's Hospital, Sharjah, ARE.

Interstitial lung disease (ILD) is a rare disease defined as a specific type of chronic fibrosing interstitial pneumonitis whose effects are limited to the lung. Nonspecific interstitial pneumonia (NSIP) was defined as a histopathological form that can be seen in the presence of large different clinical and radiological features. The exact role of thyroid hormone in the pathogenetic mechanism of idiopathic interstitial pneumonitis (IIP) is unclear. Read More

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Ivermectin-Induced Acute Psychosis in Patients Infected With COVID-19 Pneumonia.

Cureus 2022 Jun 21;14(6):e26141. Epub 2022 Jun 21.

Medicine, CHRISTUS Spohn Hospital, Corpus Christi - Shoreline, Corpus Christi, USA.

Coronavirus disease 2019 (COVID-19) pneumonia is an infection of the lungs that causes severe inflammation in the lungs' alveoli. It causes alveoli to fill with fluid, blood clots, and sometimes even pus. Patients who are infected with COVID-19 pneumonia experience severe cough, shortness of breath, fever, fatigue, chest pain, night sweats, chills, loss of appetite, etc. Read More

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ORFeome Phage Display Reveals a Major Immunogenic Epitope on the S2 Subdomain of SARS-CoV-2 Spike Protein.

Viruses 2022 Jun 17;14(6). Epub 2022 Jun 17.

Institut für Biochemie, Biotechnologie und Bioinformatik, Abteilung Biotechnologie, Technische Universität Braunschweig, Spielmannstr 7, 38106 Braunschweig, Germany.

The development of antibody therapies against SARS-CoV-2 remains a challenging task during the ongoing COVID-19 pandemic. All approved therapeutic antibodies are directed against the receptor binding domain (RBD) of the spike, and therefore lose neutralization efficacy against emerging SARS-CoV-2 variants, which frequently mutate in the RBD region. Previously, phage display has been used to identify epitopes of antibody responses against several diseases. Read More

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Cardiac Complications of COVID-19 in Low-Risk Patients.

Viruses 2022 Jun 17;14(6). Epub 2022 Jun 17.

Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London SW7 2AZ, UK.

The coronavirus disease 2019 (COVID-19) pandemic has resulted in over 6 million deaths and significant morbidity across the globe. Alongside common respiratory symptoms, COVID-19 is associated with a variety of cardiovascular complications in the acute and post-acute phases of infection. The suggested pathophysiological mechanisms that underlie these complications include direct viral infection of the myocardium via the angiotensin-converting enzyme 2 (ACE2) protein and a cytokine release syndrome that results in indirect inflammatory damage to the heart. Read More

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Repurposing an In Vitro Measles Virus Dissemination Assay for Screening of Antiviral Compounds.

Viruses 2022 May 29;14(6). Epub 2022 May 29.

Department of Viroscience, Erasmus MC, 3015 GD Rotterdam, The Netherlands.

Measles virus (MV) is a highly contagious respiratory virus responsible for outbreaks associated with significant morbidity and mortality among children and young adults. Although safe and effective measles vaccines are available, the COVID-19 pandemic has resulted in vaccination coverage gaps that may lead to the resurgence of measles when restrictions are lifted. This puts individuals who cannot be vaccinated, such as young infants and immunocompromised individuals, at risk. Read More

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mRNA BNT162b Vaccine Elicited Higher Antibody and CD4 T-Cell Responses than Patients with Mild COVID-19.

Microorganisms 2022 Jun 18;10(6). Epub 2022 Jun 18.

Microbiology and Virology Department, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy.

We compared the development and persistence of antibody and T-cell responses elicited by the mRNA BNT162b2 vaccine or SARS-CoV-2 infection. We analysed 37 post-COVID-19 patients (15 with pneumonia and 22 with mild symptoms) and 20 vaccinated subjects. Anti-Spike IgG and neutralising antibodies were higher in vaccinated subjects and in patients with pneumonia than in patients with mild COVID-19, and persisted at higher levels in patients with pneumonia while declining in vaccinated subjects. Read More

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Pulse Wave Velocity, a Predictor of Major Adverse Cardiovascular Events, and Its Correlation with the General Stress Level of Health Care Workers during the COVID-19 Pandemic.

Medicina (Kaunas) 2022 May 26;58(6). Epub 2022 May 26.

Discipline of Hygiene, Department of Microbiology, Preventive Health Education Center, University of Medicine and Pharmacy "Victor Babes", Eftimie Murgu Square, No.2, 300041 Timisoara, Romania.

In the COVID-19 epidemiological context, the health care workers who were treating patients with COVID-19 were exposed daily to additional stress. Pulse wave velocity (PWV) is a predictive parameter for possible major adverse cardiovascular events. The present study aimed to evaluate the correlation between the general stress levels and PWVs of medical workers during the COVID-19 pandemic. Read More

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The Assessment of COVID-19 Pneumonia in Neonates: Observed by Lung Ultrasound Technique and Correlated with Biomarkers and Symptoms.

J Clin Med 2022 Jun 20;11(12). Epub 2022 Jun 20.

Research Center for Pharmaco-Toxicological Evaluations, 'Victor Babes' University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania.

Newborns infected with SARS-CoV2 infection develop different symptoms in comparison with adults, but one thing is clear: some of the most common manifestations include cough and other respiratory symptoms that need to be evaluated. In these cases, lung ultrasound is a useful imaging technique that can evaluate the newborns' lung damage caused by COVID-19 pneumonia and can be used for the surveillance of the patients as well, being non-irradiating and easy to use. Nineteen neonates who were confirmed as having SARS-CoV2 infection were investigated using this imaging tool, and the results were compared and correlated with their symptoms and biomarkers. Read More

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Air Quality, Pollution and Sustainability Trends in South Asia: A Population-Based Study.

Int J Environ Res Public Health 2022 Jun 20;19(12). Epub 2022 Jun 20.

Allergy and Pulmonology, Universidad Espíritu Santo, Samborondón 0901-952, Ecuador.

Introduction: Worsening air quality and pollution lead to numerous environmental health and sustainability issues in the South Asia region. This study analyzes India, Nepal, Bangladesh, Pakistan, Sri Lanka, and Nepal for air quality data trends and sustainability indicators.

Methodology: By using a population-based study design, six South Asian countries were analyzed using a step-wise approach. Read More

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Risk Measurement of Perinatal and Neonatal Morbidity Characteristics and Applicability of GAIA Case Definitions: Results and Lessons Learnt of a Hospital-Based Prospective Cohort Study in the Valencia Region (2019-2020).

Int J Environ Res Public Health 2022 Jun 10;19(12). Epub 2022 Jun 10.

Vaccines Research Department, Fundación Para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (Fisabio), Av. de Catalunya, 21, 46020 Valencia, Spain.

Post-marketing safety surveillance of new vaccines aimed to be administered during pregnancy is crucial to orchestrate efficient adverse events evaluation. This is of special relevance in the current landscape of new vaccines being introduced in the pregnant women population, and particularly due to the recent administration of COVID-19 vaccines in pregnant women. This multi-center prospective cohort study, nested within the WHO-Global Vaccine Safety-MCC study, involved two hospitals in the Valencia region. Read More

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Influence of Information Sources on Chinese Parents Regarding COVID-19 Vaccination for Children: An Online Survey.

Kai Li Fen Zhou

Int J Environ Res Public Health 2022 Jun 8;19(12). Epub 2022 Jun 8.

School of Journalism and Communication, Guangxi University, Nanning 530004, China.

(1) Aims: This study explored the mechanism by which exposure to different information sources on social media influences Chinese parents' intention to vaccinate their children against COVID-19. (2) Methods: We developed a research framework based on the Stimulus-Organism-Response (SOR) theory to illustrate how exposure to information sources on social media increases vaccine confidence and, as a result, parents' intentions regarding pediatric vaccination. The partial least square structural equation modeling (PLS-SEM) method was used to test the data collected through an online survey (687 valid samples). Read More

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Cascading Risks for Preventable Infectious Diseases in Children and Adolescents during the 2022 Invasion of Ukraine.

Int J Environ Res Public Health 2022 Jun 8;19(12). Epub 2022 Jun 8.

Center for Disaster & Extreme Event Preparedness (DEEP Center), P3H: Protect & Promote Population Health in Complex Crises, Department of Public Health Sciences, University of Miami Miller School of Medicine, Don Soffer Clinical Research Center Room 1507, 1120 NW 14 St., Miami, FL 33136, USA.

Russia's military incursion into Ukraine triggered the mass displacement of two-thirds of Ukrainian children and adolescents, creating a cascade of population health consequences and producing extraordinary challenges for monitoring and controlling preventable pediatric infectious diseases. From the onset of the war, infectious disease surveillance and healthcare systems were severely disrupted. Prior to the reestablishment of dependable infectious disease surveillance systems, and during the early months of the conflict, our international team of pediatricians, infectious disease specialists, and population health scientists assessed the health implications for child and adolescent populations. Read More

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Filterability of Erythrocytes in Patients with COVID-19.

Biomolecules 2022 Jun 3;12(6). Epub 2022 Jun 3.

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Healthcare of Russian Federation, Samory Mashela Str., 1, GSP-7, 117198 Moscow, Russia.

For the first time, the influence of COVID-19 on blood microrheology was studied. For this, the method of filtering erythrocytes through filters with pores of 3.5 μm was used. Read More

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Long-Term Outcomes of Congenital Diaphragmatic Hernia: Report of a Multicenter Study in Japan.

Children (Basel) 2022 Jun 8;9(6). Epub 2022 Jun 8.

Department of Pediatric Surgery, Osaka Women's and Children's Hospital, Izumi 594-1101, Japan.

Background: Treatment modalities for neonates with congenital diaphragmatic hernia (CDH) have greatly improved in recent years, with a concomitant increase in survival. However, long-term outcomes restrict the identification of optimal care pathways for CDH survivors in adolescence and adulthood. Therefore, we evaluated the long-term outcomes within the Japanese CDH Study Group (JCDHSG). Read More

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Lower Respiratory Tract Infections in Pediatric Patients with Severe Neurological Impairments: Clinical Observations and Perspectives in a Palliative Care Unit.

Children (Basel) 2022 Jun 8;9(6). Epub 2022 Jun 8.

Paediatric Palliative Care Centre, Children's and Adolescents' Hospital, Witten/Herdecke University, 58448 Witten, Germany.

Pediatric palliative care (PPC) patients with a severe neurologic impairment (SNI) suffer considerable morbidity and increased mortality from lower respiratory tract infections (LRTIs). The indication and choice of antibiotic therapy for bacterial LRTIs are often challenging given the lack of evidence-based treatment recommendations for this vulnerable patient population. We conducted an observational study before the SARS-CoV-2 pandemic in an eight-bed pediatric palliative care inpatient unit. Read More

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Thrombocytosis, haemorrhagic pleural effusion and fibro-infiltrative patches with cavitary lung lesions in a child with COVID-19 pneumonia.

BMJ Case Rep 2022 Jun 23;15(6). Epub 2022 Jun 23.

Pediatrics, King George's Medical University, Lucknow, Uttar Pradesh, India.

COVID-19 infection in children is relatively mild and is associated with fewer complications compared with adults. Here we report the case of a previously healthy preteen girl who presented with active COVID-19 and shock. On day 1, ultrasound of the thorax revealed a right-sided pleural effusion with haemorrhagic pus on diagnostic tap, which improved clinically with appropriate hospital treatment. Read More

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