5,402 results match your criteria Pneumonia Nosocomial


Rapid, Visual Detection of Using Magnetic Nanoparticles and an Horseradish Peroxidase-Probe Based Immunosensor.

J Biomed Nanotechnol 2019 May;15(5):1061-1071

is a common human pathogen that causes several nosocomial chronic infections. Many methods have been reported to detect ; however, a simple, rapid, and visual method remains to be developed. Here, we developed a rapid, visual detection method employing a nanoparticle immunosensor (NPIS) with a sensitivity of 8 CFU mL. Read More

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http://dx.doi.org/10.1166/jbn.2019.2736DOI Listing

Infections and outcomes after cardiac surgery-The impact of outbreaks traced to transesophageal echocardiography probes.

Acta Anaesthesiol Scand 2019 Mar 19. Epub 2019 Mar 19.

Department of Anaesthesia and Intensive Care, Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland.

Background: Infections are a frequent complication of cardiac surgery. The intraoperative use of transesophageal echocardiography (TEE) may be an underrecognized risk factor for post-operative infections. The aim of this study was to investigate infection rates and outcomes after cardiac surgery in a nationwide cohort, especially in relation to periods where surface damaged TEE probes were used. Read More

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http://dx.doi.org/10.1111/aas.13360DOI Listing

A Breath of Fresh Air in the Fog of Antimicrobial Resistance: Inhaled Polymyxins for Gram-Negative Pneumonia.

Antibiotics (Basel) 2019 Mar 16;8(1). Epub 2019 Mar 16.

Department of Pharmacy Practice, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Room 164 (M/C 886), Chicago, IL 60612, USA.

Despite advancements in therapy, pneumonia remains the leading cause of death due to infectious diseases. Novel treatment strategies are desperately needed to optimize the antimicrobial therapy of patients suffering from this disease. One such strategy that has recently garnered significant attention is the use of inhaled antibiotics to rapidly achieve therapeutic concentrations directly at the site of infection. Read More

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http://dx.doi.org/10.3390/antibiotics8010027DOI Listing

Nebulized Amikacin and Fosfomycin for Severe Pseudomonas aeruginosa Pneumonia: An Experimental Study.

Crit Care Med 2019 Mar 15. Epub 2019 Mar 15.

Department of Pulmonary and Critical Care Medicine, Hospital Clinic, Barcelona, Spain.

Objectives: Latest trials failed to confirm merits of nebulized amikacin for critically ill patients with nosocomial pneumonia. We studied various nebulized and IV antibiotic regimens in a porcine model of severe Pseudomonas aeruginosa pneumonia, resistant to amikacin, fosfomycin, and susceptible to meropenem.

Design: Prospective randomized animal study. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003724DOI Listing
March 2019
1 Read

Triple combination therapy with high-dose ampicillin/sulbactam, high-dose tigecycline and colistin in the treatment of ventilator-associated pneumonia caused by pan-drug resistant Acinetobacter baumannii: a case series study.

Infez Med 2019 Mar;27(1):11-16

Department of Internal Medicine, Division of Infectious Diseases, University of Patras Medical School, Patras, Greece.

Acinetobacter baumannii has evolved in recent decades as a major problem in carbapenem-resistant gram-negative nosocomial infections, associated with high mortality rates especially in intensive care units (ICUs). Recent reports highlight the increasing prevalence of resistance to colistin, a last resort therapeutic option for carbapenem-resistant A. baumannii. Read More

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Pneumonia-Specific Escherichia coli with Distinct Phylogenetic and Virulence Profiles, France, 2012-2014.

Emerg Infect Dis 2019 Apr;25(4):710-718

In a prospective, nationwide study in France of Escherichia coli responsible for pneumonia in patients receiving mechanical ventilation, we determined E. coli antimicrobial susceptibility, phylotype, O-type, and virulence factor gene content. We compared 260 isolates with those of 2 published collections containing commensal and bacteremia isolates. Read More

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http://dx.doi.org/10.3201/eid2504.180944DOI Listing

Unusual presentation of late-onset disseminated staphylococcal sepsis in a preterm infant.

BMJ Case Rep 2019 Mar 15;12(3). Epub 2019 Mar 15.

Neonatal Intensive Care Unit, St Mary's Hospital, Manchester, UK.

An ex-30-week gestation, preterm male baby was admitted to a tertiary neonatal unit and noted to have increased ventilator requirements and diagnosed with sepsis. The baby also developed an abscess over the left elbow and over the xiphisternum along with a decrease in movement of the left hand and the right leg. Panton-Valentine leukocidin (PVL)-producing (SA) was isolated from the blood culture. Read More

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http://dx.doi.org/10.1136/bcr-2018-226325DOI Listing

Pulmonary infections prime the development of subsequent ICU-acquired pneumonia in septic shock.

Ann Intensive Care 2019 Mar 15;9(1):39. Epub 2019 Mar 15.

Service de médecine intensive-réanimation, Hôpital Cochin, Hôpitaux Universitaires Paris-Centre, Assistance Publique - Hôpitaux de Paris, 27 Rue du Faubourg Saint-Jacques, 75014, Paris, France.

Purpose: To investigate the determinants and the prognosis of intensive care unit (ICU)-acquired pneumonia in patients with septic shock.

Methods: This single-center retrospective study was conducted in a medical ICU in a tertiary care center from January 2008 to December 2016. All consecutive patients diagnosed for septic shock within the first 48 h of ICU admission were included. Read More

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http://dx.doi.org/10.1186/s13613-019-0515-xDOI Listing
March 2019
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Epidemiological, clinical, and microbiological characteristics of carbapenemase-producing Enterobacteriaceae bloodstream infection in the Republic of Korea.

Antimicrob Resist Infect Control 2019 5;8:48. Epub 2019 Mar 5.

Division of Infectious Diseases, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, 59, Daesagwan-ro, Yongsan-gu, Seoul, 04401 Republic of Korea.

Background: Carbapenemase-producing Enterobacteriaceae (CPE) is an important pathogen in nosocomial infections; nevertheless, only a few studies regarding CPE infection and its epidemiological factors have been conducted in the Republic of Korea (ROK). We aimed to analyze the clinical, microbiological, and epidemiological characteristics of CPE bloodstream infections (BSIs) in the ROK.

Methods: This retrospective cohort study included data collected from the National Surveillance System from January 2015 to December 2016 based on the epidemiologic survey performed by an epidemiologist from the Korea Centers for Disease Control and Prevention. Read More

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https://aricjournal.biomedcentral.com/articles/10.1186/s1375
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http://dx.doi.org/10.1186/s13756-019-0497-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402157PMC
March 2019
2 Reads

Epidemiology of Surgical Site Infections and Non-Surgical Infections in Neurosurgical Polish Patients-Substantial Changes in 2003⁻2017.

Int J Environ Res Public Health 2019 Mar 13;16(6). Epub 2019 Mar 13.

Department of Microbiology, Faculty of Medicine, Jagiellonian University Collegium Medicum, 31-121 Kraków, Poland.

: The objective of the analysis was to determine the epidemiology of healthcare-associated infections (HAIs) in neurosurgical patients, paying special attention to two time points, 2003 and 2017, in order to evaluate the effectiveness of a surveillance program introduced in 2003 and efforts to reduce infection rates. : Continuous surveillance during 2003⁻2017 carried out using the HAI-Net methodology allowed us to detect 476 cases of HAIs among 10,332 patients staying in a 42-bed neurosurgery unit. The intervention in this before⁻after study (2003⁻2017) comprised standardized HAI surveillance with regular analysis and feedback. Read More

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http://dx.doi.org/10.3390/ijerph16060911DOI Listing

Community Acquired Legionnaire's Disease in a Kidney Transplant Patient.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2018 Dec;39(2-3):45-49

Department of Nephrology, Arterial Hypertension, Dialysis and Transplantation, University Hospital Centre Zagreb, Zagreb, Croatia.

This case report details the clinical picture of a renal transplant recipient infected with community acquired Legionella pneumonia. While it is more commonly associated as a nosocomial infection due to pathogenic organisms in a hospital's water supply, this case serves as a reminder to consider the patient's impaired cellular immune function when trying to diagnose community acquired pneumonia. Read More

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http://dx.doi.org/10.2478/prilozi-2018-0041DOI Listing
December 2018

[Clinical observation on application of different enteral nutrition preparations in patients with severe traumatic brain injury].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2019 Feb;31(2):209-213

Department of Critical Care Medicine, the Affiliated Hospital of Guizhou Medical University, Guiyang 550004, Guizhou, China. Corresponding author: Wang Difen, Email:

Objective: To observe the effects of enteral nutrition (EN) emulsion with different components on nutritional index, blood glucose, inflammatory reaction, gastrointestinal tolerance and prognosis in patients with severe traumatic brain injury (sTBI).

Methods: Patients with sTBI [Glasgow coma scale (GCS) < 8] admitted to intensive care unit (ICU) of Affiliated Hospital of Guizhou Medical University from January 2016 to May 2018 were retrospectively analyzed. These patients had received EN, 30 cases of them were fed with Baipuli, 35 cases were fed with Ruineng, and 30 cases were fed with Ruisu. Read More

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http://dx.doi.org/10.3760/cma.j.issn.2095-4352.2019.02.017DOI Listing
February 2019
2 Reads

Adherence to antibiotic guidelines and reported penicillin allergy: pooled cohort data on prescribing and allergy documentation from two English National Health Service (NHS) trusts.

BMJ Open 2019 Mar 1;9(2):e026624. Epub 2019 Mar 1.

Imperial College Healthcare NHS Trust, London, UK.

Objective: To investigate documentation of antimicrobial allergy and to determine prescribing adherence to local antibiotic guidelines for inpatients with and without reported penicillin allergy treated for infection in a National Health Service (NHS) context.

Setting: Data were collected at two English hospital NHS trusts over two time-periods: June 2016 and February 2017.

Design: Cohort study. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026624DOI Listing
March 2019
1 Read

Healthcare-asociated pneumonia:Any reasons to still utilize this label in 2019?

Clin Microbiol Infect 2019 Feb 27. Epub 2019 Feb 27.

Scottish Centre for Respiratory Research, University of Dundee, NinewellsHospital and Medical School, Dundee, DD1 9SY, UK.

Backround: There is an ongoing controversy on the role of the HCAP label in the treatment of patients with pneumonia.

Objective: To provide an update of the literature on patients meeting criteria for healthcare-associated pneumonia 2014-2018.

Sources: The review was based on a systematic literature search using Pub Med-Central full-text archive of biomedical and life sciences journal literature at the U. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.02.022DOI Listing
February 2019
2 Reads

Duration of antibiotic treatment for common infections in English primary care: cross sectional analysis and comparison with guidelines.

BMJ 2019 Feb 27;364:l440. Epub 2019 Feb 27.

Modelling and Economics Unit, National Infection Service, Public Health England, London NW9 5EQ, UK.

Objective: To evaluate the duration of prescriptions for antibiotic treatment for common infections in English primary care and to compare this with guideline recommendations.

Design: Cross sectional study.

Setting: General practices contributing to The Health Improvement Network database, 2013-15. Read More

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http://dx.doi.org/10.1136/bmj.l440DOI Listing
February 2019
2 Reads

Characterization of Clinically Relevant Strains of Extended-Spectrum β-Lactamase-Producing Occurring in Environmental Sources in a Rural Area of China by Using Whole-Genome Sequencing.

Front Microbiol 2019 12;10:211. Epub 2019 Feb 12.

Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.

is a gram-negative, opportunistic pathogen, and a common cause of healthcare-associated infections such as pneumonia, septicemia, and urinary tract infection. The purpose of this study was to survey the occurrence of and characterize in different environmental sources in a rural area of Shandong province, China. Two hundred and thirty-one samples from different environmental sources in 12 villages were screened for extended-spectrum β-lactamase-(ESBL)-producing , and 14 (6%) samples were positive. Read More

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http://dx.doi.org/10.3389/fmicb.2019.00211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379450PMC
February 2019
1 Read

Genomic epidemiology of severe community-onset Acinetobacter baumannii infection.

Microb Genom 2019 Feb 26. Epub 2019 Feb 26.

6​Faculty of Science, Health, Education and Engineering, University of the Sunshine Coast, Sippy Downs 4072, Australia.

Acinetobacter baumannii causes severe, fulminant, community-acquired pneumonia (CAP) in tropical and subtropical regions. We compared the population structure, virulence and antimicrobial resistance determinants of northern Australian community-onset A. baumannii strains with local and global strains. Read More

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http://dx.doi.org/10.1099/mgen.0.000258DOI Listing
February 2019
1 Read

Global Metabolic Analyses of Acinetobacter baumannii.

Methods Mol Biol 2019 ;1946:321-328

Laboratory of Antimicrobial Systems Pharmacology, Department of Microbiology, Biomedicine Discovery Institute, Monash University, Melbourne, VIC, Australia.

Acinetobacter baumannii is rapidly emerging as a multidrug-resistant pathogen responsible for nosocomial infections including pneumonia, bacteremia, wound infections, urinary tract infections, and meningitis. Metabolomics provides a powerful tool to gain a system-wide snapshot of cellular biochemical networks under defined conditions and has been increasingly applied to bacterial physiology and drug discovery. Here we describe an optimized sample preparation method for untargeted metabolomics studies in A. Read More

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http://dx.doi.org/10.1007/978-1-4939-9118-1_28DOI Listing
January 2019
1 Read

Performance of the extended use of the FilmArray BCID panel kit for bronchoalveolar lavage analysis.

Mol Biol Rep 2019 Feb 23. Epub 2019 Feb 23.

Laboratoire de Bactériologie, CHU Angers, 4 rue Larrey, 49933, Angers cedex, France.

Ventilator-associated pneumonia (VAP) are responsible for an increase in morbidity, mortality, and prolonged hospital stay. A multiplex PCR kit such as the FilmArray BCID panel could allow early adaptation of antimicrobial therapy, which is crucial for clinical outcomes. The purpose of this study was to test the performances of FilmArray BCID panel for the detection of bacteria producing VAP. Read More

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http://dx.doi.org/10.1007/s11033-019-04710-0DOI Listing
February 2019
1 Read

Aspiration Pneumonia in Older Adults.

J Hosp Med 2019 Feb 20;14:E1-E7. Epub 2019 Feb 20.

Northwell Health, Manhasset, New York.

Aspiration pneumonia refers to an infection of the lung parenchyma in an individual that has inhaled a bolus of endogenous flora that overwhelms the natural defenses of the respiratory system. While there are not universally agreed upon criteria, the diagnosis can be made in patients with the appropriate risk factors and clinical scenario, in addition to a radiographic or an ultrasonographic image of pneumonia in the typical dependent lung segment. Treatment options for aspiration pneumonia vary based on the site of acquisition (community-acquired aspiration pneumonia [CAAP] versus healthcare-associated aspiration pneumonia [HCAAP]), the risk for multidrug-resistant (MDR) organisms, and severity of illness. Read More

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http://dx.doi.org/10.12788/jhm.3154DOI Listing
February 2019
2 Reads

Implementation of infection prevention and control in acute care hospitals in Mainland China - a systematic review.

Antimicrob Resist Infect Control 2019 11;8:32. Epub 2019 Feb 11.

Infection Control Program and WHO Collaborating Centre on Patient Safety, University of Geneva Hospitals and Faculty of Medicine, Rue Gabrielle Perret-Gentil 4, 1211 Geneva 14, Switzerland.

Background: Healthcare-associated infections (HAIs) and antimicrobial resistance (AMR) affect patients in acute-care hospitals worldwide. No systematic review has been published on adoption and implementation of the infection prevention and control (IPC) key components. The objective of this systematic review was to assess adoption and implementation of the three areas issued by the "National Health Commission of the People's Republic of China" in acute-care hospitals in Mainland China, and to compare the findings with the key and core components on effective IPC, issued by the European Centre for Disease Prevention and Control (ECDC) and the World Health Organization (WHO). Read More

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http://dx.doi.org/10.1186/s13756-019-0481-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371478PMC
February 2019
1 Read

Infections in Neonatal Intensive Care Units (NICUs).

Int J Environ Res Public Health 2019 Feb 20;16(4). Epub 2019 Feb 20.

Department of Health Sciences, University of Genoa, Italy Via Pastore, 1-16132 Genoa, Italy.

belongs to the family Enterobacteriaceae, which is commonly found in water, soil, animals, insects, plants. Although displays relatively low virulence, it causes nosocomial infections and outbreaks in severely immunocompromised or critically ill patients, particularly in settings such as intensive care units (ICUs), especially neonatal units (NICUs). This microorganism gives rise to a wide range of clinical manifestations in newborns: from asymptomatic colonization to keratitis, conjunctivitis, urinary tract infections, pneumonia, surgical wound infections, sepsis, bloodstream infection and meningitis. Read More

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http://dx.doi.org/10.3390/ijerph16040610DOI Listing
February 2019
1 Read

An Acinetobacter baumannii, Zinc-Regulated Peptidase Maintains Cell Wall Integrity during Immune-Mediated Nutrient Sequestration.

Cell Rep 2019 Feb;26(8):2009-2018.e6

Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address:

Acinetobacter baumannii is an important nosocomial pathogen capable of causing wound infections, pneumonia, and bacteremia. During infection, A. baumannii must acquire Zn to survive and colonize the host. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.01.089DOI Listing
February 2019
2 Reads

Description of Clinical Characteristics of VAP Patients in MIMIC Database.

Front Pharmacol 2019 4;10:62. Epub 2019 Feb 4.

Clinical Research Center, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Ventilator-associated pneumonia (VAP) is a common and serious nosocomial infection of intensive-care units (ICUs). Accurate, timely diagnosis enables early VAP patients to receive appropriate therapies and reduce the occurrence of complication. However, so far clinical datas regarding the epidemiology and mortality of VAP are still limited. Read More

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http://dx.doi.org/10.3389/fphar.2019.00062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369200PMC
February 2019
5 Reads

Burden of healthcare-associated infections at six tertiary-care hospitals in Saudi Arabia: A point prevalence survey.

Infect Control Hosp Epidemiol 2019 Mar 19;40(3):355-357. Epub 2019 Feb 19.

Infection Prevention and Control Department, King Abdulaziz Medical City (KAMC),Ministry of National Guard Health Affairs (MNGHA),Riyadh,Saudi Arabia.

A point prevalence survey was conducted on May 11, 2017, among inpatients at 6 hospitals in Saudi Arabia. The overall point prevalence was 6.8% (114 of 1,666). Read More

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http://dx.doi.org/10.1017/ice.2018.338DOI Listing
March 2019
3 Reads

The clinical impacts and risk factors for non-central line-associated bloodstream infection in 5046 intensive care unit patients: an observational study based on electronic medical records.

Crit Care 2019 Feb 18;23(1):52. Epub 2019 Feb 18.

Department of Infection Control, West China Hospital of Sichuan University, Chengdu, China.

Background: Most of the previous studies focused on central line-associated bloodstream infection (CLABSI), while non-central line-associated bloodstream infection (N-CLABSI) was poorly studied. This study was performed to investigate the clinical impacts and risk factors for N-CLABSI in intensive care unit (ICU) patients.

Methods: An observational study was conducted in an adult general ICU. Read More

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http://dx.doi.org/10.1186/s13054-019-2353-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379966PMC
February 2019
3 Reads

Nosocomial Pneumonia in the ICU: Still More Questions Than Answers.

Crit Care Med 2019 Mar;47(3):472-473

Critical Care Institute, Keck Hospital of USC; and Division of Trauma, Emergency Surgery and Surgical Critical Care, Department of Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA.

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http://dx.doi.org/10.1097/CCM.0000000000003600DOI Listing

Increased Healthcare-Associated Infections in a Surgical Intensive Care Unit Related to Boarding Non-Surgical Patients.

Surg Infect (Larchmt) 2019 Feb 15. Epub 2019 Feb 15.

3 Department of Surgery, Division of Acute Care Surgery Rutgers-Robert Wood Johnson Medical School, New Brunswick, New Jersey.

Background: Hospital over-capacity often forces boarding patients outside of their designated intensive care unit (ICU). Anecdotal evidence suggested medical intensive care unit (MICU) patients boarding in the surgical intensive care unit (SICU) were responsible for increases in healthcare-associated infection (HAI) rates. We studied the effect of ICU boarding on rates of SICU HAIs. Read More

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https://www.liebertpub.com/doi/10.1089/sur.2018.240
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http://dx.doi.org/10.1089/sur.2018.240DOI Listing
February 2019
4 Reads

A Case of Fulminant Bacillus cereus Lung Necrosis in a Preterm Neonate.

Pediatr Dev Pathol 2019 Feb 13:1093526619825895. Epub 2019 Feb 13.

5 Department of Pathology and Laboratory Medicine, The Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.

Bacillus cereus is a ubiquitous Gram-positive rod seldom considered pathogenic in clinical isolates. However, it possesses multiple virulence factors explaining why it has been linked to fulminant and pyogenic infections in vulnerable hosts. Its recovery from sterile samples in immunocompromised patients cannot be disregarded. Read More

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http://dx.doi.org/10.1177/1093526619825895DOI Listing
February 2019
1 Read

In vitro activities of antimicrobial peptides and ceragenins against Legionella pneumophila.

J Antibiot (Tokyo) 2019 Feb 12. Epub 2019 Feb 12.

Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Istanbul University, Beyazit, Istanbul, 34116, Turkey.

Legionella pneumophila is a waterborne intracellular pathogenic bacterium, the most frequent cause of human legionellosis and a relatively common cause of community-acquired and nosocomial pneumonia. Some legionellosis outbreaks are related to the presence of biofilms, which provide a reservoir for L. pneumophila strains. Read More

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http://dx.doi.org/10.1038/s41429-019-0148-1DOI Listing
February 2019
1 Read

The prevalence of healthcare-associated infection in medical intensive care units in Tunisia. Results of the multi-centre nosorea1 study.

Tunis Med 2018 Oct-Nov;96(10-11):731-736

Objectives: To determine the prevalence of Healthcare-Associated Infection (HAI) in medical Intensive Care Unit (ICU), risk factors for these infections and identify the predominant infecting organisms.

Methods: A 1-day point-prevalence study within all medical ICUs in Tunisia, all patients occupying an ICU bed over a 48-hour period were included. Rates of HAI, resistance patterns of microbiological isolates and potential risk factors for HAI were recorded. Read More

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February 2019
3 Reads

Risk of community-acquired pneumonia in older adults with sarcopenia of a hospital from Callao, Peru 2010-2015.

Arch Gerontol Geriatr 2019 Jan 29;82:100-105. Epub 2019 Jan 29.

Universidad de San Martin de Porres, Facultad de Medicina Humana, Centro de investigación del evejecimiento (CIEN), Lima, Peru; Universidad Científica del Sur, Lima, Peru.

Introduction: Sarcopenia is a geriatric syndrome characterized by loss of muscle mass and strength. The prevalence in people between 60-70 years is about 5-13% and in adults over 80 years, between 11-50% in the USA. Sarcopenia increases the risk of mortality and nosocomial infections. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01674943193000
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http://dx.doi.org/10.1016/j.archger.2019.01.008DOI Listing
January 2019
10 Reads

Health care-associated infection surveillance system in Iran: Reporting and accuracy.

Am J Infect Control 2019 Feb 6. Epub 2019 Feb 6.

Department of Health in Emergency and Disaster, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Background: Valid data are a crucial aspect of infection prevention and control programs. The aim of this study was to examine the accuracy of routine reporting in the Iranian Nosocomial Infection Surveillance System in intensive care units.

Methods: A blinded retrospective review of general intensive care unit medical records was performed with a standard case-finding form. Read More

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http://dx.doi.org/10.1016/j.ajic.2018.12.028DOI Listing
February 2019
2 Reads
2.206 Impact Factor

A case report of community-acquired Pseudomonas aeruginosa pneumonia complicated with MODS in a previously healthy patient and related literature review.

BMC Infect Dis 2019 Feb 8;19(1):130. Epub 2019 Feb 8.

Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, Republic of China.

Background: Pseudomonas aeruginosa is an unusual pathogen in community-acquired pneumonia, especially in previously healthy adults, but often indicates poor prognosis.

Case Presentation: We report a previously healthy patient who developed severe community-acquired pneumonia (CAP) caused by P. aeruginosa. Read More

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http://dx.doi.org/10.1186/s12879-019-3765-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368713PMC
February 2019
2 Reads

Pneumonia in hospitalized neurologic patients: trends in pathogen distribution and antibiotic susceptibility.

Antimicrob Resist Infect Control 2019 1;8:25. Epub 2019 Feb 1.

1Department of Neurology, Laboratory for Neurotherapeutics, Biomedical Research Institute, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 110-744 South Korea.

Background: Bed-ridden state, dysphagia, altered mental state, or respiratory muscle weakness are common in neurologic patients and increase the risk of pneumonia. The major causes of pneumonia in neurologic patients may differ from those in the general population, resulting in a different pathogen distribution. We investigated the trends of pathogen distribution in culture-positive pneumonia in hospitalized neurologic patients and the related antibiotic resistance in those with hospital-acquired pneumonia (HAP). Read More

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http://dx.doi.org/10.1186/s13756-019-0475-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359823PMC
February 2019
3 Reads

Study the antibacterial and antibiofilm activity of Carum copticum against antibiotic-resistant bacteria in planktonic and biofilm forms.

Microb Pathog 2019 Apr 4;129:99-105. Epub 2019 Feb 4.

Department of Biology, Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman, Iran.

Objectives: Microbial biofilms has attracted interest in the recent years because they has become the most important cause of nosocomial infections. This study was aimed to examine the antibacterial activities of Carum copticum extracts on the development of microbial biofilms and planktonic form of six pathogenic bacteria.

Methods: Antimicrobial activity of the crude extracts against the planktonic form of six pathogenic bacteria: Bacillus cereus, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Acinetobacter baumannii and Klebsiella pneumonia was evaluated by using the disc diffusion method. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.02.002DOI Listing
April 2019
3 Reads

Evaluation of Lactobacilli for Antagonistic Activity Against the Growth, Adhesion and Invasion of and .

Indian J Microbiol 2019 Mar 27;59(1):81-89. Epub 2018 Jul 27.

2Department of Food and Nutrition, Providence University, Taichung City, 43301 Taiwan, ROC.

Urinary tract infections are the most common infectious diseases in babies and the elderly and are often acquired as nosocomial infections. The purpose of the present study was to identify strains of lactic acid bacteria (LAB) which could be used as alternatives to antibiotics for the treatment of urinary tract infections because of their ability to inhibit urinary tract pathogens ( BCRC 10694 and BCRC 17040). We screened 370 LAB strains using spent culture supernatants by inhibition zone assay to assess their antimicrobial effects. Read More

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http://dx.doi.org/10.1007/s12088-018-0753-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328402PMC
March 2019
2 Reads

Cefiderocol: A Siderophore Cephalosporin with Activity Against Carbapenem-Resistant and Multidrug-Resistant Gram-Negative Bacilli.

Drugs 2019 Feb;79(3):271-289

Department of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.

Cefiderocol is an injectable siderophore cephalosporin discovered and being developed by Shionogi & Co., Ltd., Japan. Read More

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http://dx.doi.org/10.1007/s40265-019-1055-2DOI Listing
February 2019
3 Reads

Investigation of multidrug-resistant ST2 Acinetobacter baumannii isolated from Saint George hospital in Lebanon.

BMC Microbiol 2019 Feb 2;19(1):29. Epub 2019 Feb 2.

Aix Marseille Univ, IRD, APHM, MEPHI, IHU-Méditerranée Infection, Faculté de Médecine et de Pharmacie, 19-21 boulevard Jean Moulin, 13385, Marseille, Cedex 05, France.

Background: Acinetobacter baumannii is an opportunistic pathogen causing various nosocomial infections. The spread of multidrug-resistant A. baumannii is a major public health problem. Read More

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http://dx.doi.org/10.1186/s12866-019-1401-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359860PMC
February 2019
1 Read

The Role of the CopA Copper Efflux System in Virulence.

Int J Mol Sci 2019 Jan 29;20(3). Epub 2019 Jan 29.

Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide 5005, South Australia, Australia.

has emerged as one of the leading causative agents of nosocomial infections. Due to its high level of intrinsic and adapted antibiotic resistance, treatment failure rates are high, which allows this opportunistic pathogen to thrive during infection in immune-compromised patients. can cause infections within a broad range of host niches, with pneumonia and bacteraemia being associated with the greatest levels of morbidity and mortality. Read More

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http://dx.doi.org/10.3390/ijms20030575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387184PMC
January 2019
1 Read

Characterization of post-surgical critical patients with infections associated with healthcare after prolonged perfusion of remifentanil.

Rev Assoc Med Bras (1992) 2018 Aug;64(8):736-742

. Departamento de Farmacología e Instituto de Neurociencias. Facultad de Medicina, Universidad de Granada, Granada, Spain.

Introduction: Healthcare associated infections (HAI) are the most frequent complication of hospitalized patients. The aim of this study was to describe the clinical and epidemiological characteristics of critically ill post-surgical patients with a diagnosis of healthcare associated infections, after a pattern of sedoanalgesia of at least 4 days.

Methods: All patients over 18 years of age with a unit admission of more than 4 days were consecutively selected. Read More

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http://dx.doi.org/10.1590/1806-9282.64.08.736DOI Listing
August 2018
2 Reads

Burden of Respiratory Syncytial Virus Disease and Mortality Risk Factors in Argentina: 18 Years Active Surveillance in a Children´s Hospital.

Pediatr Infect Dis J 2019 Jan 10. Epub 2019 Jan 10.

Virology, Ricardo Gutiérrez Children's Hospital, Buenos Aires, Argentina.

Background: Respiratory Syncytial Virus (RSV) is the leading cause of acute lower respiratory infection (ALRI) in children. We aimed to describe the clinical-epidemiological pattern and risk factors for mortality associated with RSV infection.

Methods: A prospective, cross-sectional study of ALRI in children admitted to the Children's Hospital among 2000-2017. Read More

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http://Insights.ovid.com/crossref?an=00006454-900000000-9646
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http://dx.doi.org/10.1097/INF.0000000000002271DOI Listing
January 2019
11 Reads

Dose Selection and Validation for Ceftazidime-Avibactam in Adults with Complicated Intra-Abdominal Infections, Complicated Urinary Tract Infections and Nosocomial Pneumonia.

Antimicrob Agents Chemother 2019 Jan 22. Epub 2019 Jan 22.

AstraZeneca, Waltham, MA, USA.

Avibactam is a non-β-lactam β-lactamase inhibitor that has been approved in combination with ceftazidime for the treatment of complicated intra-abdominal infections, complicated urinary tract infections and nosocomial pneumonia, including ventilator-associated pneumonia. In Europe, ceftazidime-avibactam is also approved for the treatment of Gram-negative infections with limited treatment options. Selection and validation of the ceftazidime-avibactam dosage regimen was guided by an iterative process of population pharmacokinetic (PK) modelling, whereby population PK models for ceftazidime and avibactam were developed using PK data from clinical trials and updated periodically. Read More

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http://aac.asm.org/lookup/doi/10.1128/AAC.02187-18
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http://dx.doi.org/10.1128/AAC.02187-18DOI Listing
January 2019
9 Reads

Comparison of OmpA Gene-Targeted Real-Time PCR with the Conventional Culture Method for Detection of Acinetobacter baumanii in Pneumonic BALB/c Mice

Iran Biomed J 2019 03;23(2):159-64

Dept. of Cell Biology, Science and Research branch, Islamic Azad University, Tehran, Iran.

Background: Acinetobacter baumannii is an important pathogen in health care and is responsible for severe nosocomial and community-acquired pneumonia. To design novel therapeutic agents, a mouse model for A. baumannii pneumonia is essential. Read More

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March 2019
6 Reads

Tug of war between Acinetobacter baumannii and host immune responses.

Pathog Dis 2018 12;76(9)

Department of Immunology and infectious Diseases, John Curtin School of Medical Research, Australian National University, 131 Garran Road, Acton, ACT 2601, Australia.

Acinetobacter baumannii is an emerging nosocomial, opportunistic pathogen with growing clinical significance. Acinetobacter baumannii has an exceptional ability to rapidly develop drug resistance and to adhere to abiotic surfaces, including medical equipment, significantly promoting bacterial spread and also limiting our ability to control A. baumannii infections. Read More

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https://academic.oup.com/femspd/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/femspd/ftz004DOI Listing
December 2018
8 Reads

Analysis of acute respiratory infections due to influenza virus A, B and RSV during an influenza epidemic 2018.

Infection 2019 Jan 16. Epub 2019 Jan 16.

Kliniken für Pneumologie und Infektiologie, EVK Herne und Augusta-Kranken-Anstalt Bochum, Thoraxzentrum Ruhrgebiet, Bergstrasse 26, 44791, Bochum, Germany.

Purpose: We studied the incidence, morbidity and mortality of all patients presenting in our teaching hospital with proven influenza virus and/or respiratory syncytial virus (RSV) infection during the influenza epidemic season 2018 which was characterized by a predominant incidence of influenza virus B type B of the Yamagata line.

Methods: In the fall of 2017, specific precaution measures in addition to standard measures were implemented, including standardized testing for influenza virus A,B and RSV by multiplex PCR of pharyngeal swabsData from all consecutive patients were analyzed retrospectively.

Results: Overall 651 patients were examined for the presence of influenza virus and RSV; 214 patients had influenza virus A (n = 36), B (n = 152), and/or RSV (n = 30), including four patients with dual infection. Read More

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http://link.springer.com/10.1007/s15010-018-1262-x
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http://dx.doi.org/10.1007/s15010-018-1262-xDOI Listing
January 2019
20 Reads

[Treatment strategies for congenital heart disease in infants with severe pneumonia].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Nov;43(11):1241-1245

Department of Cardiovascular Surgery, Xiangya Hospital, Central South University, Changsha 410008, China.

Objective: To observe the results of different treatment of congenital heart disease (CHD) complicated with severe pneumonia in infants.
 Methods: A total of 27 infants with CHD and severe pneumonia were admitted to the Department of Pediatrics, Xiangya Hospital from January 2014 to December 2014, of whom 18 were male and 9 were female. The average age was 2. Read More

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http://dx.doi.org/10.11817/j.issn.1672-7347.2018.11.012DOI Listing
November 2018
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The impact of glycemic variability on length of stay and mortality in diabetic patients admitted with community-acquired pneumonia or chronic obstructive pulmonary disease.

Diabetes Metab Syndr 2019 Jan - Feb;13(1):149-153. Epub 2018 Aug 28.

Instituto Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal.

Aim: To investigate the influence of glycemic variability (GV) on length of stay and in-hospital mortality in non-critical diabetic patients.

Methods: A observation retrospective study was performed. Diabetic patients admitted between January and June 2016 with the diagnosis of community-acquire pneumonia (CAP) and/or acute exacerbation of chronic obstructive pulmonary disease (COPD) were enrolled and glycemic control (persistent hyperglycemia, hypoglycemia, mean glucose level (MGL) and respective standard deviation (SD) and coefficient of variation (CV)) were evaluated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18714021183034
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http://dx.doi.org/10.1016/j.dsx.2018.08.028DOI Listing
August 2018
5 Reads