10,155 results match your criteria Pneumonia Nosocomial


A nationwide retrospective analysis of ventilator-associated pneumonia in the US.

Proc (Bayl Univ Med Cent) 2022 24;35(4):410-414. Epub 2022 Mar 24.

College of Medicine, Central Michigan University, Saginaw, Michigan.

Ventilator-associated pneumonia (VAP) is a major cause of healthcare-associated mortality and morbidity in critically ill patients who are mechanically ventilated. The purpose of this study was to describe the various primary discharge diagnoses of hospitalizations with VAP, to identify their demographic characteristics, and to identify risk factors for mortality in hospitalizations with VAP. Hospitalizations with a diagnosis of VAP with mechanical ventilation for over 24 hours were selected from the National Inpatient Sample in 2016 and 2017. Read More

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Biosensors for with Molecularly Imprinted Polymer (MIP) Technique.

Sensors (Basel) 2022 Jun 20;22(12). Epub 2022 Jun 20.

Department of Biomedical Engineering, School of Engineering, King Mongkut's Institute of Technology Ladkrabang, Bangkok 10520, Thailand.

Nosocomial infection is one of the most important problems that occurs in hospitals, as it directly affects susceptible patients or patients with immune deficiency. ( is the most common cause of nosocomial infections in hospitals. can cause various diseases such as pneumonia, urinary tract infections, septicemias, and soft tissue infections, and it has also become highly resistant to antibiotics. Read More

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Healthcare-Acquired Infection Surveillance in Neurosurgery Patients, Incidence and Microbiology, Five Years of Experience in Two Polish Units.

Int J Environ Res Public Health 2022 Jun 20;19(12). Epub 2022 Jun 20.

Department of Microbiology, Jagiellonian University, 31-121 Kraków, Poland.

Introduction: Patients in neurosurgical units are particularly susceptible to healthcare-associated infections (HAI) due to invasive interventions in the central nervous system.

Materials And Methods: The study was conducted between 2014 and 2019 in neurosurgery units in Poland. The aim of the study was to investigate the epidemiology and microbiology of HAIs and to assess the effectiveness of surveillance conducted in two hospital units. Read More

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Cost Analysis for Patients with Ventilator-Associated Pneumonia in the Neonatal Intensive Care Unit.

Healthcare (Basel) 2022 May 25;10(6). Epub 2022 May 25.

Department of Epidemiology and Disaster Medicine, Faculty of Public Health, Medical University of Plovdiv, 4002 Plovdiv, Bulgaria.

The concept of improving the quality and safety of healthcare is well known. However, a follow-up question is often asked about whether these improvements are cost-effective. The prevalence of nosocomial infections (NIs) in the neonatal intensive care unit (NICU) is approximately 30% in developing countries. Read More

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Knowledge of intensive care nurses' towards prevention of ventilator-associated pneumonia in North West Ethiopia referral hospitals, 2021: A multicenter, cross-sectional study.

Ann Med Surg (Lond) 2022 Jun 3;78:103895. Epub 2022 Jun 3.

Department of Human Physiology, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Introduction: Ventilator-associated pneumonia is a common nosocomial infection that occurs in critically ill patients who are on intubation and mechanical ventilation. Nurses' lack of knowledge may be a barrier to adherence to evidence-based guidelines for preventing ventilator-associated pneumonia. This study aimed to assess the knowledge of intensive care nurses' towards the prevention of ventilator-associated pneumonia. Read More

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Prevalence of multidrug-resistant strains in device associated nosocomial infection and their in vitro killing by nanocomposites.

Ann Med Surg (Lond) 2022 Jun 3;78:103687. Epub 2022 May 3.

Department of Biotechnology, MMEC, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana, 133207, India.

Background: As per WHO, global burden of healthcare-associated infections (HAIs) ranges between 7% and 12%. There is a dire need to screen Device associated nosocomial infections (DANIs) in hospitals(1). To investigate the prevalence of microbes in hospitals in DANI cases and analyse in vitro control of multi-drug resistant strains by nanotechnology intervention. Read More

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Bronchoscopy in Critically Ill COVID-19 Patients: Findings, Microbiological Profile, and Coinfection.

J Bronchology Interv Pulmonol 2022 Jul 22;29(3):186-190. Epub 2021 Sep 22.

Pneumology Unit.

Background: Bronchoscopy is a widely use technique in critically ill patients. Nosocomial coinfections are a cause of morbidity and mortality in intensive care units.

Objectives: Our aim was to describe bronchoscopy findings and analyze microbiological profile and probably coinfection through bronchial aspirate (BA) samples in patients with coronavirus disease 2019 pneumonia requiring intensive care unit admission. Read More

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Major candidate variables to guide personalised treatment with steroids in critically ill patients with COVID-19: CIBERESUCICOVID study.

Intensive Care Med 2022 Jun 21. Epub 2022 Jun 21.

Department of Intensive Care Medicine, Hospital Universitario, 12 de Octubre, Madrid, Spain.

Purpose: Although there is evidence supporting the benefits of corticosteroids in patients affected with severe coronavirus disease 2019 (COVID-19), there is little information related to their potential benefits or harm in some subgroups of patients admitted to the intensive care unit (ICU) with COVID-19. We aim to investigate to find candidate variables to guide personalized treatment with steroids in critically ill patients with COVID-19.

Methods: Multicentre, observational cohort study including consecutive COVID-19 patients admitted to 55 Spanish ICUs. Read More

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Nosocomial Pneumonia in the Mechanically Ventilated Patient.

Semin Respir Crit Care Med 2022 Jun 17. Epub 2022 Jun 17.

Critical Care Research Group, The Prince Charles Hospital, Brisbane, Australia.

Ventilator-associated pneumonia (VAP) is a common complication occurring in critically ill patients who are mechanically ventilated and is the leading cause of nosocomial infection-related death. Etiologic agents for VAP widely differ based on the population of intensive care unit patients, duration of hospital stay, and prior antimicrobial therapy. VAP due to multidrug-resistant pathogens is associated with the highest morbidity and mortality, likely due to delays in appropriate antimicrobial treatment. Read More

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Prophylactic acid suppressants in patients with primary neurologic injury: A systematic review and meta-analysis of randomized controlled trials.

J Crit Care 2022 Jun 14;71:154093. Epub 2022 Jun 14.

Toronto Western Hospital, Toronto, Ontario, Canada; Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada; Department of Medicine (Respirology), University Health Network, Toronto, Canada. Electronic address:

Purpose: Neurocritical care patients are at risk of stress-induced gastrointestinal ulceration. We performed a systematic review and meta-analysis of stress ulcer prophylaxis (SUP) in critically ill adults admitted with a primary neurologic injury.

Materials And Methods: We included randomized controlled trials (RCTs) comparing SUP with histamine-2-receptor antagonists (H2RAs) or proton pump inhibitors (PPIs) to placebo/no prophylaxis, as well as to each other. Read More

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ESBL production and carbapenem resistance increased the secondary bloodstream infection rates in intensive care units in Turkey, 2014-2019.

GMS Hyg Infect Control 2022 11;17:Doc05. Epub 2022 Apr 11.

Ministry of Health, General Directorate of Public Health, Ankara, Turkey.

Aim: Secondary bloodstream infections (SBSIs) are caused by another infection and differ from primary bloodstream infections (PBSIs) in terms of prevention and treatment strategies. The aim of this study was to determine the risk factors for bloodstream infections which were secondary to the most common healthcare-associated infections caused by the most common microorganisms in intensive care units (ICUs) and to examine whether extended-spectrum beta lactamase (ESBL) production and carbapenem resistance is related to the higher risk or not.

Methods: The study population consisted of patients in ICUs with ventilator-associated pneumonia (VAP), ventilator-associated event (VAE) or catheter-associated urinary tract infection (CAUTI) caused by or between 2014 and 2019. Read More

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Stress ulcer prophylaxis for critically ill children: routine use needs to be re-examined.

An Pediatr (Engl Ed) 2022 May 19;96(5):402-409. Epub 2021 Mar 19.

Departamento de Pediatría, Facultad de Medicina, Universidad de Menufia, Shibin el-Kom, Egypt.

Introduction: Stress ulcer prophylaxis (SUP) is commonly used in Paediatric Intensive Care Units (PICUs). However, strong evidence for this practice is lacking and there is a dire need for paediatric randomized controlled trials (RCTs). Our aim was to assess the usefulness of SUP with omeprazole in critically ill children. Read More

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Impact of dexamethasone on the incidence of ventilator-associated pneumonia in mechanically ventilated COVID-19 patients: a propensity-matched cohort study.

Crit Care 2022 06 13;26(1):176. Epub 2022 Jun 13.

Dipartimento di Anestesia, Rianimazione ed Emegenza Urgenza, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122, Milan, Italy.

Objective: To assess the impact of treatment with steroids on the incidence and outcome of ventilator-associated pneumonia (VAP) in mechanically ventilated COVID-19 patients.

Design: Propensity-matched retrospective cohort study from February 24 to December 31, 2020, in 4 dedicated COVID-19 Intensive Care Units (ICU) in Lombardy (Italy).

Patients: Adult consecutive mechanically ventilated COVID-19 patients were subdivided into two groups: (1) treated with low-dose corticosteroids (dexamethasone 6 mg/day intravenous for 10 days) (DEXA+); (2) not treated with corticosteroids (DEXA-). Read More

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Molecular epidemiology and outcome of carbapenem-resistant Enterobacterales in Saudi Arabia.

BMC Infect Dis 2022 Jun 13;22(1):542. Epub 2022 Jun 13.

Department of Medicine, King Abdulaziz Medical City, Jeddah, Saudi Arabia.

Background: The burden of carbapenem resistance is not well studied in the Middle East. We aimed to describe the molecular epidemiology and outcome of carbapenem-resistant Enterobacterales (CRE) infections from several Saudi Arabian Centers.

Methods: This is a multicenter prospective cohort study conducted over a 28-month period. Read More

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An Overview of Healthcare Associated Infections and Their Detection Methods Caused by Pathogen Bacteria in Romania and Europe.

J Clin Med 2022 Jun 4;11(11). Epub 2022 Jun 4.

Department of Clinical Pharmacy, Faculty of Pharmacy, "Iuliu Hațieganu" University of Medicine and Pharmacy Cluj-Napoca, 400349 Cluj-Napoca, Romania.

Healthcare-associated infections can occur in different care units and can affect both patients and healthcare professionals. Bacteria represent the most common cause of nosocomial infections and, due to the excessive and irrational use of antibiotics, resistant organisms have appeared. The most important healthcare-associated infections are central line-associated bloodstream infections, catheter-associated urinary tract infections, surgical site, soft tissue infections, ventilator-associated pneumonia, hospital acquired pneumonia, and colitis. Read More

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The Role of Lung Ultrasound Monitoring in Early Detection of Ventilator-Associated Pneumonia in COVID-19 Patients: A Retrospective Observational Study.

J Clin Med 2022 May 26;11(11). Epub 2022 May 26.

Anesthesia and Intensive Care, Fondazione IRCCS Policlinico San Matteo, DEA piano-1, Viale Camillo Golgi, 19, 27100 Pavia, Italy.

Specific lung ultrasound signs combined with clinical parameters allow for early diagnosis of ventilator-associated pneumonia in the general ICU population. This retrospective cohort study aimed to determine the accuracy of lung ultrasound monitoring for ventilator-associated pneumonia diagnosis in COVID-19 patients. Clinical (i. Read More

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Ventilator-associated pneumonia prevention in the Intensive care unit using Postpyloric tube feeding in China (VIP study): study protocol for a randomized controlled trial.

Trials 2022 Jun 9;23(1):478. Epub 2022 Jun 9.

Department of Critical Care Medicine, Maoming People's Hospital, 101 Weimin Road, Maoming, 525000, Guangdong, China.

Background: Ventilator-associated pneumonia is a challenge in critical care and is associated with high mortality and morbidity. Although some consensuses on preventing ventilator-associated pneumonia are reached, it is still somewhat controversial. Meta-analysis has shown that postpyloric tube feeding may reduce the incidences of ventilator-associated pneumonia, which still desires high-quality evidence. Read More

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Developing and validating a prediction model for in-hospital mortality in patients with ventilator-associated pneumonia in the ICU.

Ann Palliat Med 2022 May;11(5):1799-1810

Department of Hepatobiliary and Pancreatic Surgery, The Affiliated Huai'an No. 1 People's Hospital of Nanjing Medical University, Huai'an, China.

Background: Ventilator-associated pneumonia (VAP) is a common nosocomial infection in the intensive care unit (ICU), with high in-hospital mortality. Current scoring systems are limited in predicting nosocomial death of VAP. This study aimed to develop and validate a more accurate and effective prediction model for in-hospital mortality in ICU patients with VAP. Read More

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Efficacy and Activity of Novel Antibiotics for Infections With Carbapenem-Resistant Gram-Negative Pathogens.

Front Cell Infect Microbiol 2022 20;12:884365. Epub 2022 May 20.

Laboratorio de Microbiología Molecular, Departamento de Bioquímica y Medicina Molecular, Facultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey, Mexico.

Infections by Gram-negative multi-drug resistant (MDR) bacterial species are difficult to treat using available antibiotics. Overuse of carbapenems has contributed to widespread resistance to these antibiotics; as a result, carbapenem-resistant Enterobacterales (CRE), (CRAB), and (CRPA) have become common causes of healthcare-associated infections. Carbapenems, tigecycline, and colistin are the last resource antibiotics currently used; however, multiple reports of resistance to these antimicrobial agents have been documented worldwide. Read More

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COVID-19: the possibility, ways, mechanisms, and interruptions of mother-to-child transmission.

Arch Gynecol Obstet 2022 Jun 4. Epub 2022 Jun 4.

Division of Neonatology, Department of Pediatrics, The Affiliated Hospital of Southwest Medical University, Luzhou, China.

Background: In December 2019, novel coronavirus pneumonia was detected in Wuhan, Hubei Province, China, and as the epidemic spread, such cases emerged worldwide. Recently, the World Health Organization (WHO) named a new mutant Omicron (B.1. Read More

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Airway Epithelial Cells Differentially Adapt Their Iron Metabolism to Infection With and .

Front Cell Infect Microbiol 2022 18;12:875543. Epub 2022 May 18.

Department of Internal Medicine II, Infectious Diseases, Immunology, Rheumatology, Medical University of Innsbruck, Innsbruck, Austria.

Background: Pneumonia is often elicited by bacteria and can be associated with a severe clinical course, respiratory failure and the need for mechanical ventilation. In the alveolus, type-2-alveolar-epithelial-cells (AECII) contribute to innate immune functions. We hypothesized that AECII actively adapt cellular iron homeostasis to restrict this essential nutrient from invading pathogens - a defense strategy termed 'nutritional immunity', hitherto mainly demonstrated for myeloid cells. Read More

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Hyperimmune Targeting Staphylococcal Toxins Effectively Protect Against USA 300 MRSA Infection in Mouse Bacteremia and Pneumonia Models.

Front Immunol 2022 17;13:893921. Epub 2022 May 17.

Integrated Biotherapeutics Inc. (IBT), Rockville, MD, United States.

has been acquiring multiple drug resistance and has evolved into superbugs such as Methicillin/Vancomycin-resistant (MRSA/VRSA) and, consequently, is a major cause of nosocomial and community infections associated with high morbidity and mortality for which no FDA-approved vaccines or biotherapeutics are available. Previous efforts targeting the surface-associated antigens have failed in clinical testing. Here, we generated hyperimmune products from sera in rabbits against six major toxins targeted by an experimental vaccine (IBT-V02) and demonstrated significant efficacy for an anti-virulence passive immunization strategy. Read More

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Comparative incidence of early and late bloodstream and respiratory tract co-infection in patients admitted to ICU with COVID-19 pneumonia versus Influenza A or B pneumonia versus no viral pneumonia: wales multicentre ICU cohort study.

Crit Care 2022 06 2;26(1):158. Epub 2022 Jun 2.

Adult Critical Care Directorate, University Hospital of Wales, Heath Park, Cardiff, UK.

Objective: The aim is to characterise early and late respiratory and bloodstream co-infection in patients admitted to intensive care units (ICUs) with SARS-CoV-2-related acute hypoxemic respiratory failure (AHRF) needing respiratory support in seven ICUs within Wales, during the first wave of the COVID-19 pandemic. We compare the rate of positivity of different secondary pathogens and their antimicrobial sensitivity in three different patient groups: patients admitted to ICU with COVID-19 pneumonia, Influenza A or B pneumonia, and patients without viral pneumonia.

Design: Multicentre, retrospective, observational cohort study with rapid microbiology data from Public Health Wales, sharing of clinical and demographic data from seven participating ICUs. Read More

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Oral Microbes in Hospital-Acquired Pneumonia: Practice and Research Implications.

Crit Care Nurse 2022 Jun;42(3):47-54

Mary Lou Sole is dean, professor, and Orlando Health Endowed Chair in Nursing at the University of Central Florida College of Nursing.

Background: Hospital-acquired pneumonia accounts for 25% of all health care-associated infections and is classified as either ventilator-associated or non-ventilator-associated pneumonia. Hospital-acquired pneumonia most frequently results from aspiration of oropharyngeal secretions into the lungs. Although preventive measures for ventilator-associated pneumonia are well established, few preventive measures exist for the nonventilator type. Read More

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Bacterial etiology and mortality rate in community-acquired pneumonia, healthcare-associated pneumonia and hospital-acquired pneumonia in Thai university hospital.

Sci Rep 2022 May 30;12(1):9004. Epub 2022 May 30.

Division of Infectious Disease, Department of Medicine, Phramongkutklao Hospital and College of Medicine, Bangkok, 10400, Thailand.

Pneumonia is caused by infection at the pulmonary parenchyma which constitutes a crucial risk factor for morbidity and mortality. We aimed to determine the mortality rate and its risk factors as well as etiology among inpatients with community-acquired pneumonia (CAP), hospital-acquired pneumonia (HAP) and healthcare-associated pneumonia (HCAP). A hospital-based retrospective cohort study was conducted in a university hospital located in Bangkok, Thailand. Read More

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A retrospective evaluation of multiple definitions for ventilator associated pneumonia (VAP) diagnosis in an Australian regional intensive care unit.

Infect Dis Health 2022 May 27. Epub 2022 May 27.

Mackay Base Hospital, Australia. Electronic address:

Background: Ventilator Associated Pneumonia is a common complication of invasively ventilated patients with significant and underestimated morbidity and mortality. Defining VAP cases is greatly varied as many definitions are used with varying success and sensitivity. This study evaluates VAP detection using four definitions in a regional Australian Intensive Care Unit (ICU). Read More

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Identification and Comparative Genomic Analysis of Type VI Secretion Systems and Effectors in .

Front Microbiol 2022 12;13:853744. Epub 2022 May 12.

Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China.

is a nosocomial opportunistic pathogen that can cause pneumonia, liver abscesses, and infections of the bloodstream. The resistance and pathogenicity of pose major challenges to clinical practice. However, the ecology and pathogenic mechanisms of have not been fully elucidated. Read More

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Bacterial Community and Genomic Analysis of Carbapenem-Resistant Isolates from the Environment of a Health Care Facility in the Western Region of Saudi Arabia.

Pharmaceuticals (Basel) 2022 May 16;15(5). Epub 2022 May 16.

Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.

The escalating transmission of hospital-acquired infections, especially those due to antimicrobial-resistant bacteria, is a major health challenge worldwide. In this study, a culturomic analysis of bacterial community in a tertiary care hospital in the western region of Saudi Arabia is performed using environmental samples. The genome sequencing of four was performed on isolates recovered from an intensive care unit (ICU) environment and clinical samples. Read More

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The Effect of Professional Oral Care on the Oral Health Status of Critical Trauma Patients Using Ventilators.

Int J Environ Res Public Health 2022 05 19;19(10). Epub 2022 May 19.

Department of Dental Hygiene, College of Software and Digital Healthcare Convergence, Yonsei University, Wonju 26493, Korea.

Background: Oral care reduces the incidence of ventilator-associated pneumonia. In addition, it is important that critically ill patients to maintain their oral health in order to restore their quality of life and to receive adequate nutrition after recovery.

Objective: The purpose of this study was to evaluate the effect of professional oral hygiene care (POHC) on the oral health status of patients using a ventilator. Read More

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Antibiotic therapy of postoperative bronchopneumonia in patients after lung resections - single-site experience.

Rozhl Chir 2022 ;101(4):168-175

Introduction: Infectious complications after lung surgery are the most important factor that affects mortality and morbidity, prolongs hospital stays and increases financial costs. According to various sources, 30-day mortality after lung resections reaches 123%. Infectious complications account for 2075% of overall mortality. Read More

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