8,788 results match your criteria Pneumonia Nosocomial


PROPHETIC: Prospective Identification of Pneumonia in Hospitalized Patients in the Intensive Care Unit.

Chest 2020 Jun 29. Epub 2020 Jun 29.

Duke University, Durham, NC, USA; Duke Clinical Research Institute, Durham, NC, USA.

Background: Pneumonia is the leading infection-related cause of death. Using simple clinical criteria and contemporary epidemiology to identify patients at high risk of nosocomial pneumonia should enhance prevention efforts and facilitate development of new treatments in clinical trials.

Research Question: What are the clinical criteria and contemporary epidemiology trends helpful in identifying patients at high risk of nosocomial pneumonia?

Study Design And Methods: Within the intensive care units of 28 United States hospitals, we conducted a prospective cohort study among adults hospitalized more than 48 hours and considered high risk for pneumonia (defined as treatment with invasive or noninvasive ventilatory support or high levels of supplemental oxygen). Read More

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http://dx.doi.org/10.1016/j.chest.2020.06.034DOI Listing

Detection of several carbapenems resistant and virulence genes in classical and hyper-virulent strains of Klebsiella pneumoniae isolated from hospitalized neonates and adults in Khartoum.

BMC Res Notes 2020 Jul 1;13(1):312. Epub 2020 Jul 1.

Biochemistry Department, Faculty of Sciences, King Abdulaziz University, Jeddah, 21452, Saudi Arabia.

Objective: Klebsiella pneumoniae (K. pneumoniae) involves both community-acquired and nosocomial infections. It is responsible for a wide variety of infections, including infections of the urinary tract, pneumonia, bacteremia, meningitis, wound infection and purulent abscesses. Read More

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http://dx.doi.org/10.1186/s13104-020-05157-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328261PMC

Structure and process associated with the efficiency of intensive care units in low-resource settings: An analysis of the CHECKLIST-ICU trial database.

J Crit Care 2020 Jun 18;59:118-123. Epub 2020 Jun 18.

D'Or Institute for Research and Education (IDOR), Rio de Janeiro, RJ, Brazil; Brazilian Research in Intensive Care Network (BRICNet), Brazil; Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, RJ, Brazil. Electronic address:

Purpose: Characteristics of structure and process impact ICU performance and the outcomes of critically ill patients. We sought to identify organizational characteristics associated with efficient ICUs in low-resource settings.

Materials And Methods: This is a secondary analysis of a multicenter cluster-randomized clinical trial in Brazil (CHECKLIST-ICU). Read More

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http://dx.doi.org/10.1016/j.jcrc.2020.06.008DOI Listing

The impact of antimicrobial stewardship program implementation at four tertiary private hospitals: results of a five-years pre-post analysis.

Antimicrob Resist Infect Control 2020 29;9:95. Epub 2020 Jun 29.

Research Center, Dr Sulaiman Al Habib Medical Group, Riyadh, Saudi Arabia.

Background: Antimicrobial stewardship (AMS) programs have shown to reduce the emergence of antimicrobial resistance (AMR) and health-care-associated infections (HAIs), and save health-care costs associated with an inappropriate antimicrobial use. The primary objective of this study was to compare the consumption and cost of antimicrobial agents using defined daily dose (DDD) and direct cost of antibiotics before and after the AMS program implementation. Secondary objective was to determine the rate of HAIs [ (), ventilator-associated pneumonia (VAP), and central line-associated bloodstream infection (CLABSI) before and after the AMS program implementation. Read More

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http://dx.doi.org/10.1186/s13756-020-00751-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322716PMC

Bacterial and fungal coinfection among hospitalised patients with COVID-19: A retrospective cohort study in a UK secondary care setting.

Clin Microbiol Infect 2020 Jun 27. Epub 2020 Jun 27.

Chelsea and Westminster NHS Foundation Trust, 369 Fulham Road, London, SW10 9NH. UK; North West London Pathology, Imperial College Healthcare NHS Trust, Fulham Palace Road. London. W6 8RF. UK; National Institute for Health Research Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Imperial College London, Hammersmith Campus, Du Cane Road, London. W12 0NN. UK.

Objectives: We investigate the incidence of bacterial and fungal co-infection of hospitalised patients with confirmed SARS-CoV-2 in this retrospective observational study across two London hospitals during the first UK wave of COVID-19.

Methods: A retrospective case-series of hospitalised patients with confirmed SARS-CoV-2 by PCR was analysed across two acute NHS hospitals (February 20-April 20; each isolate reviewed independently in parallel). This was contrasted to a control group of influenza positive patients admitted during 2019/20 flu season. Read More

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http://dx.doi.org/10.1016/j.cmi.2020.06.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320692PMC

Corticosteroid administration for viral pneumonia: COVID-19 and beyond.

Clin Microbiol Infect 2020 Jun 27. Epub 2020 Jun 27.

the Department of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address:

Background: Corticosteroids are commonly used as adjuvant therapy for acute respiratory distress syndrome (ARDS) by many clinicians due to their perceived anti-inflammatory effects. However, for patients with severe viral pneumonia, the corticosteroid treatment is highly controversial.

Objectives: The purpose of this review is to systematically evaluate the effect and potential mechanism of corticosteroid administration in pandemic viral pneumonia. Read More

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http://dx.doi.org/10.1016/j.cmi.2020.06.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320691PMC

Safety Profile of Ceftazidime-Avibactam: Pooled Data from the Adult Phase II and Phase III Clinical Trial Programme.

Drug Saf 2020 Jun 29. Epub 2020 Jun 29.

AstraZeneca, Alderley Park, Macclesfield, UK.

Introduction: Ceftazidime-avibactam combines the established anti-pseudomonal cephalosporin, ceftazidime, with the novel non-β-lactam β-lactamase inhibitor, avibactam.

Objectives: The aim of this study was to evaluate the safety of ceftazidime-avibactam in adults using pooled data from two phase II (NCT00690378, NCT00752219) and five phase III (NCT01499290, NCT01726023, NCT01644643, NCT01808093 and NCT01595438/NCT01599806) clinical studies.

Methods: Safety data from seven multicentre, randomised, active-comparator studies were pooled by study group at the patient level for descriptive analyses, comprising patients with complicated urinary tract infection (cUTI), including pyelonephritis, complicated intra-abdominal infection (cIAI), or nosocomial pneumonia (NP), including ventilator-associated pneumonia (VAP), treated with ceftazidime-avibactam ± metronidazole or comparator. Read More

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http://dx.doi.org/10.1007/s40264-020-00934-3DOI Listing

Measures for preventing nosocomial infection with SARS-CoV-2 in hematology departments.

Ann Hematol 2020 Jun 29. Epub 2020 Jun 29.

Department of Hematology, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuhan, 430071, People's Republic of China.

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http://dx.doi.org/10.1007/s00277-020-04127-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323882PMC

The impact of antimicrobial stewardship program implementation at four tertiary private hospitals: results of a five-years pre-post analysis.

Antimicrob Resist Infect Control 2020 Jun 29;9(1):95. Epub 2020 Jun 29.

Research Center, Dr Sulaiman Al Habib Medical Group, Riyadh, Saudi Arabia.

Background: Antimicrobial stewardship (AMS) programs have shown to reduce the emergence of antimicrobial resistance (AMR) and health-care-associated infections (HAIs), and save health-care costs associated with an inappropriate antimicrobial use. The primary objective of this study was to compare the consumption and cost of antimicrobial agents using defined daily dose (DDD) and direct cost of antibiotics before and after the AMS program implementation. Secondary objective was to determine the rate of HAIs [Clostridium difficile (C. Read More

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http://dx.doi.org/10.1186/s13756-020-00751-4DOI Listing

Update of the treatment of nosocomial pneumonia in the ICU.

Crit Care 2020 Jun 29;24(1):383. Epub 2020 Jun 29.

ICU, Trinity Centre for Health Science HRB-Wellcome Trust, St James's Hospital, Dublin, Ireland.

In accordance with the recommendations of, amongst others, the Surviving Sepsis Campaign and the recently published European treatment guidelines for hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP), in the event of a patient with such infections, empirical antibiotic treatment must be appropriate and administered as early as possible. The aim of this manuscript is to update treatment protocols by reviewing recently published studies on the treatment of nosocomial pneumonia in the critically ill patients that require invasive respiratory support and patients with HAP from hospital wards that require invasive mechanical ventilation. An interdisciplinary group of experts, comprising specialists in anaesthesia and resuscitation and in intensive care medicine, updated the epidemiology and antimicrobial resistance and established clinical management priorities based on patients' risk factors. Read More

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http://dx.doi.org/10.1186/s13054-020-03091-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322703PMC

Economic evaluation alongside the Probiotics to Prevent Severe Pneumonia and Endotracheal Colonization Trial (E-PROSPECT): study protocol.

BMJ Open 2020 Jun 28;10(6):e036047. Epub 2020 Jun 28.

Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.

Introduction: Ventilator-associated pneumonia (VAP) is a common healthcare-associated infection in the intensive care unit (ICU). Probiotics are defined as live microorganisms that may confer health benefits when ingested. Prior randomised trials suggest that probiotics may prevent infections such as VAP and -associated diarrhoea (CDAD). Read More

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http://dx.doi.org/10.1136/bmjopen-2019-036047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322334PMC

[Practice of nosocomial infection management in burn department based on the American hospital evaluation standard of the Joint Commission International].

Zhonghua Shao Shang Za Zhi 2020 Jun;36(6):488-492

Department of Burns, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China.

To explore the role of continuous quality improvement measures based on the American hospital evaluation standard of the Joint Commission International (JCI) in prevention and control of nosocomial infection in Burn Department of the Second Affiliated Hospital of Zhejiang University School of Medicine (hereinafter referred to as the author' s department). From 2013 to 2018, based on 11 JCI standards related to infection prevention and control and the current situation of the author' s department, more than 50 doctors, nurses, and nursing assistants from the author' s department participated in continuous improvement of the three-level management system of nosocomial infection in the author' s department, focusing on implementing of management of patient with multidrug resistant bacteria infection, optimizing the infection control management of instrument and cloth, and implementing target management on 5 indicators such as hand hygiene implementation rate, and carrying out inspection, quality management, and improvement on 11 items of prevention and control of nosocomial infection. The implementation rate of hand hygiene from 2013 to 2018 and the accuracy rate of hand hygiene from 2016 to 2018 of medical staff in the author' s department, and incidences of catheter-related bloodstream infection (CRBSI) of central venous, catheter-associated urinary tract infection (CAUTI), and ventilator associated pneumonia (VAP) of burn intensive care unit in the author's department from 2013 to 2018 were monitored. Read More

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http://dx.doi.org/10.3760/cma.j.cn501120-20190206-00020DOI Listing

The enclosed ward management strategies in psychiatric hospitals during COVID-19 outbreak.

Global Health 2020 06 24;16(1):53. Epub 2020 Jun 24.

The Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.

During the COVID-19 pandemic, as a large city located in Southwest China, Chengdu was mainly affected by imported cases. For a psychiatric hospital, the enclosed management model, the crowded wards and the uncooperative patients are the risk factors of nosocomial infection. Admitting new patients while preventing the COVID-19 outbreak within the institutions was a crucial challenge. Read More

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http://dx.doi.org/10.1186/s12992-020-00586-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312105PMC

Gastric ulcer due to mucormycosis in a critical patient.

Rev Esp Enferm Dig 2020 Jun 24;112. Epub 2020 Jun 24.

Aparato Digestivo, Hospital General Universitario Morales Meseguer , España.

We have read the article published by Sánchez-Velázquez P et al., which described a clinical case of gastrointestinal hemorrhage secondary to gastric ulcer due to Mucor. We present a similar clinical case, as an example of one identified by gastroscopy. Read More

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http://dx.doi.org/10.17235/reed.2020.6636/2019DOI Listing

A rare case of pneumonia complicated by .

Clin Case Rep 2020 Jun 13;8(6):1039-1043. Epub 2020 Mar 13.

Internal Medicine Department No. 3 with Phthisiology Ukrainian Medical Stomatological Academy Poltava Ukraine.

pneumonia immunocompromised the patient with subsequent complication by a rare opportunistic infection, which became a nosocomial pathogen in the healthcare setting. Read More

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http://dx.doi.org/10.1002/ccr3.2800DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303856PMC

The Response of to Hydrogen Sulfide Reveals Two Independent Persulfide-Sensing Systems and a Connection to Biofilm Regulation.

mBio 2020 Jun 23;11(3). Epub 2020 Jun 23.

Department of Chemistry, Indiana University, Bloomington, Indiana, USA

is an opportunistic nosocomial pathogen that is the causative agent of several serious infections in humans, including pneumonia, sepsis, and wound and burn infections. is also capable of forming proteinaceous biofilms on both abiotic and epithelial cell surfaces. Here, we investigate the response of toward sodium sulfide (NaS), known to be associated with some biofilms at oxic/anoxic interfaces. Read More

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http://dx.doi.org/10.1128/mBio.01254-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315123PMC

Clinical Characteristics and Reasons for Differences in Duration From Symptom Onset to Release From Quarantine Among Patients With COVID-19 in Liaocheng, China.

Front Med (Lausanne) 2020 12;7:210. Epub 2020 May 12.

Intensive Care Unit, Liaocheng People's Hospital, Liaocheng, China.

This study aimed to identify additional characteristics and features of coronavirus disease (COVID-19) by assessing the clinical courses among COVID-19 patients in a region outside Hubei province. We analyzed retrospective data regarding general characteristics, epidemiologic history, underlying chronic diseases, clinical symptoms and complications, chest computed tomography findings, biochemical monitoring, disease severity, treatments, and outcomes among 37 adult patients with COVID-19. According to the duration from symptom onset to release from quarantine, the patients were divided into the ≤20 and >20-day groups, and the similarities and differences between them were compared. Read More

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http://dx.doi.org/10.3389/fmed.2020.00210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235406PMC

COVID19: A Systematic Approach to Early Identification and Healthcare Worker Protection.

Front Public Health 2020 19;8:205. Epub 2020 May 19.

ENT Institute and Otorhinolaryngology Department of the Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.

The COVID-19 outbreak spread rapidly throughout the globe, with worldwide infections and deaths continuing to increase dramatically. To control disease spread and protect healthcare workers, accurate information is necessary. We searched PubMed and Google Scholar for studies published from December 2019 to March 31, 2020 with the terms "COVID-19," "2019-nCoV," "SARS-CoV-2," or "Novel Coronavirus Pneumonia. Read More

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http://dx.doi.org/10.3389/fpubh.2020.00205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248242PMC

The epidemiologic and clinical features of suspected and confirmed cases of imported 2019 novel coronavirus pneumonia in north Shanghai, China.

Ann Transl Med 2020 May;8(10):637

Department of Gastrointestinal Surgery Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai 200072, China.

Background: A recent cluster of pneumonia cases in Wuhan (China) is known to be caused by a novel beta-coronavirus named the corona virus disease 2019 (COVID-19) and can be spread through human-to-human transmission.

Methods: Data of 21 patients with laboratory-confirmed COVID-19 and 84 patients with suspected COVID-19 were analyzed by RT-PCR. The epidemiologic and clinical features as well as clinical outcomes were compared between the confirmed and suspected cases. Read More

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http://dx.doi.org/10.21037/atm-20-2119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290637PMC

Healthcare-associated Infection in Intensive Care Units: Overall Analysis of Patient Criticality by Acute Physiology and Chronic Health Evaluation IV Scoring and Pathogenic Characteristics.

Indian J Crit Care Med 2020 Apr;24(4):252-257

Department of Microbiology, JSS Medical College, Mysuru, Karnataka, India.

Objectives: To compare the predicted vs observed mortality rate, criticality, and length of stay of the patients with healthcare-associated infections (HAIs) in intensive care units (ICUs) of a tertiary health center through acute physiology and chronic health evaluation (APACHE) IV scoring. To analyze the drug sensitivity pattern of the isolated pathogen.

Design: This is a prospective observational study involving the patients admitted to various ICUs of a tertiary care teaching hospital. Read More

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http://dx.doi.org/10.5005/jp-journals-10071-23384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297239PMC

[Epidemiology of SARS-CoV-2 infection and COVID-19].

Internist (Berl) 2020 Jun 16. Epub 2020 Jun 16.

Abt. Krankenhaushygiene und Infektiologie, Universitätsklinikum Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Deutschland.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new β‑Coronavirus that was first detected in 2019 in Wuhan, China. In the ensuing months it has been transmitted worldwide. Here the authors present the current knowledge on the epidemiology of this virus. Read More

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http://dx.doi.org/10.1007/s00108-020-00834-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296906PMC

Preventive and Control Measures for the Coronavirus Pandemic in Clinical Dentistry.

Chin J Dent Res 2020 ;23(2):99-104

A severe public health crisis has been declared worldwide since coronavirus disease 2019 (COVID-19) was classified as a pandemic of acute respiratory infectious disease by the World Health Organisation (WHO). China has taken strict measures to curb the spread of the disease to save lives, and has managed to control the outbreak. COVID-19 is mainly transmitted through respiratory droplets and close physical contact, so it is challenging to prevent nosocomial infection and possible spread during dental treatment. Read More

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http://dx.doi.org/10.3290/j.cjdr.a44745DOI Listing

Guidelines on the Prevention and Control of Disease in Dental Practice during the Coronavirus Outbreak.

Chin J Dent Res 2020 ;23(2):89-94

Coronavirus disease 2019 has become a worldwide pandemic that is seriously jeopardising people's health. The National Health Commission and regional health administrations have issued regulations on the prevention and control of coronavirus disease 2019. Dentistry involves many invasive treatments, which differentiates it from other forms of medical practice. Read More

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http://dx.doi.org/10.3290/j.cjdr.a44743DOI Listing

Insights Into Mechanisms of Biofilm Formation in and Implications for Uropathogenesis.

Front Cell Infect Microbiol 2020 29;10:253. Epub 2020 May 29.

Department of Microbiology and Immunology, Emory University, Atlanta, GA, United States.

Multidrug resistant is a serious healthcare threat. In fact, the Center for Disease Control recently reported that carbapenem-resistant is responsible for more than 8,500 infections, 700 deaths, and $281 million in healthcare costs annually in the United States with few, if any, treatment options available, leading to its designation as a pathogen of urgent concern and a priority for novel antimicrobial development. It is hypothesized that biofilms are, at least in part, responsible for the high prevalence of nosocomial and recurrent infections because they frequently contaminate hospital surfaces and patient indwelling devices; therefore, there has been a recent push for mechanistic understanding of biofilm formation, maturation and dispersal. Read More

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http://dx.doi.org/10.3389/fcimb.2020.00253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273844PMC

[Infection prevention and control of bedside blood purification treatment in patients with COVID-19].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Jun;52(3):414-419

Trauma center, Peking University People's Hospital, Beijing 100044, China.

Objective: To explore the infection prevention and control strategy of bedside blood purification treatment in corona virus disease 2019 (COVID-19) isolation ward, and to evaluate the effect of infection prevention and control management measures.

Methods: We summarized and analyzed the clinical features, infection status, outcome and infection prevention and control measures of bedside blood purification treatment patients in COVID-19 isolation ward from February 8, 2020 to March 31, 2020, analyzed the COVID-19 cross-infection between the patients and medical staffs, and the blood-borne pathogens cross-infection situation between the patients, and analyzed the effect of bundle prevention and control measures in controlling the occurrence and spread of cross-infection.

Results: A total of 101 COVID-19 patients were hospitalized in this COVID-19 isolation ward, of whom 10 patients (9. Read More

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http://dx.doi.org/10.19723/j.issn.1671-167X.2020.03.003DOI Listing

Controlling nosocomial infection in adult intensive treatment unit: A quality improvement project.

Int J Risk Saf Med 2020 Jun 4. Epub 2020 Jun 4.

King Hamad University Hospital, Bahrain.

Background: Nosocomial infection is a significant burden on healthcare facilities. Its multifactorial nature renders it challenging to control. However, quality healthcare necessitates a safer service that poses no harm to the patient. Read More

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http://dx.doi.org/10.3233/JRS-190028DOI Listing

[Robotic and laparosocpic urological surgery during COVID-19 pandemia.]

Arch Esp Urol 2020 Jun;73(5):463-470

Servicio de Urología. Hospital Universitario Rey Juan Carlos. Móstoles. Madrid. España.

Objective: SARS-CoV-2 pandemic hashigh repercussion on urologic minimally invasive surgery (MIS). Controversy about safety of MIS procedures during COVID-19 pandemic has been published. Nowadays, our priority should be create agreement in order to restart and organize MIS with safety conditions for patients and healthcare workers. Read More

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Risk Factors for Mortality and Respiratory Support in Elderly Patients Hospitalized with COVID-19 in Korea.

J Korean Med Sci 2020 Jun 15;35(23):e223. Epub 2020 Jun 15.

Division of Infectious Diseases, Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea.

Background: The mortality risk of coronavirus disease 2019 (COVID-19) is higher in patients with older age, and many elderly patients are reported to require advanced respiratory support.

Methods: We reviewed medical records of 98 patients aged ≥ 65 years who were hospitalized with COVID-19 during a regional outbreak in Daegu/Gyeongsangbuk-do province of Korea. The outcome measures were in-hospital mortality and the treatment with mechanical ventilation (MV) or high-flow nasal cannula (HFNC). Read More

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http://dx.doi.org/10.3346/jkms.2020.35.e223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295602PMC

Homology analysis of 51 penicillin-intermediate isolates from Wenzhou City, China.

J Int Med Res 2020 Jun;48(6):300060520919061

Department of Laboratory Medicine, Taizhou Women and Children's Hospital, Taizhou, Zhejiang Province, China.

Objective: To investigate drug resistance features and homology among penicillin-intermediate isolates from Wenzhou City, China.

Methods: Fifty-one penicillin-intermediate isolates were obtained from respiratory samples of infants and children hospitalized with lung infections. An antimicrobial susceptibility test was used to assess drug resistance. Read More

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http://dx.doi.org/10.1177/0300060520919061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294386PMC

Bundle of Coated Devices to Reduce Nosocomial Infections in the Intensive Care Unit: CRITIC Pilot Randomized Controlled Trial.

Ann Am Thorac Soc 2020 Jun 11. Epub 2020 Jun 11.

Instituto Latino-Americano de Sepsis, Sao Paulo, Brazil.

Rationale: Coated devices may reduce biofilm formation and reduce occurrence of device-related infections in critically ill patients. A bundle of coated devices (endotracheal tube - ETT, central venous catheter - CVC, urinary catheter - UC) simultaneously inserted may optimize benefits of coated devices in most severe patients.

Objectives: To assess feasibility of a randomized controlled trial on simultaneous insertion of gold-silver-palladium coated devices versus uncoated devices in severely ill patients required sequential insertion of all three devices (ETT, CVC and UC) for support in intensive care unit (ICU). Read More

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http://dx.doi.org/10.1513/AnnalsATS.202003-206OCDOI Listing

The Association of Antibiotic Duration With Successful Treatment of Community-Acquired Pneumonia in Children.

J Pediatric Infect Dis Soc 2020 Jun 11. Epub 2020 Jun 11.

Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Background: National guidelines recommend 10 days of antibiotics for children with community-acquired pneumonia (CAP), acknowledging that the outcomes of children hospitalized with CAP who receive shorter durations of therapy have not been evaluated.

Methods: We conducted a comparative effectiveness study of children aged ≥6 months hospitalized at The Johns Hopkins Hospital who received short-course (5-7 days) vs prolonged-course (8-14 days) antibiotic therapy for uncomplicated CAP between 2012 and 2018 using an inverse probability of treatment weighted propensity score analysis. Inclusion was limited to children with clinical and radiographic criteria consistent with CAP, as adjudicated by 2 infectious diseases physicians. Read More

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http://dx.doi.org/10.1093/jpids/piaa055DOI Listing

Mitral Valve Replacement Using Subvalvular Apparatus: A Systematic Review and Meta-Analysis.

Heart Surg Forum 2020 Jun 1;23(3):E385-E392. Epub 2020 Jun 1.

Institute of Anatomy, First Faculty of Medicine, Charles University.

Background: To assess clinical outcomes among participants undergoing mitral valve replacement with preservation of subvalvular apparatus.

Methods: Electronic databases, including PubMed, Embase, Science Direct, World of Science, Scopus, Biosis, SciElo and Cochrane library, were probed using an extensive search strategy. Studies that reported at least one clinical outcome, such as morbidity, mortality, early 30-day mortality, myocardial failure, survival, late cerebrovascular events, length of stay, or major operative complications (stroke, prolonged ventilation, and reoperation for bleeding, renal failure, and sternal infection) were considered for inclusion. Read More

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http://dx.doi.org/10.1532/hsf.2659DOI Listing

Cefiderocol: A Siderophore Cephalosporin.

Ann Pharmacother 2020 Jun 10:1060028020929988. Epub 2020 Jun 10.

Lebanese American University, School of Phramacy, Byblos Campus, Byblos, Lebanon.

This article reviews the available data on the chemistry, spectrum of activity, pharmacokinetic and pharmacodynamic properties, clinical efficacy, and potential place in therapy of cefiderocol. A literature search through PubMed, Google Scholar, and ClinicalTrials.gov was conducted (2009 to March 2020) using the search terms and . Read More

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http://dx.doi.org/10.1177/1060028020929988DOI Listing

Diagnostic Ultrasound Services During the Coronavirus Disease (COVID-19) Pandemic.

AJR Am J Roentgenol 2020 Jun 10:1-6. Epub 2020 Jun 10.

Division of Radiological Sciences, Singapore General Hospital, Outram Rd, Singapore, Singapore 169608.

Nosocomial transmission of coronavirus disease (COVID-19) to frontline health care workers is well known, and health care workers may inadvertently become vectors for onward transmission. Ultrasound (US) service providers are at significant risk because scanning usually requires prolonged close patient contact. The bulky US equipment may also facilitate fomite transmission of disease. Read More

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http://dx.doi.org/10.2214/AJR.20.23167DOI Listing

COVID-19 Pneumonia Mimicking Immunotherapy-Induced Pneumonitis on 18F-FDG PET/CT in a Patient Under Treatment With Nivolumab.

Clin Nucl Med 2020 Aug;45(8):e381-e382

From the Departments of Nuclear Medicine.

Within a few months, coronavirus disease 2019 (COVID-19) has become a pandemic with more than 2 million patients infected and a high mortality rate. Early detection of COVID-19 in oncologic patients is crucial in order to rapidly apply isolation measures and avoid nosocomial spread. However, early diagnosis may be challenging, especially in cancer patients under treatment with immunotherapy as drug-induced pneumonitis can present similar clinical and radiological features. Read More

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http://dx.doi.org/10.1097/RLU.0000000000003152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315837PMC
August 2020
3.931 Impact Factor

Unusual community-associated carbapenem-resistant infection, Pennsylvania, USA.

IDCases 2020 29;21:e00851. Epub 2020 May 29.

Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, PA, USA.

We report a rare case of community-acquired pneumonia and bacteremia caused by multidrug resistant . The patient was critically ill, intubated for 11 days and subsequently was discharged from the hospital in good condition after 21 days. Whole genome sequencing was performed, and isolate belonged to Sequence Type 451, which is prevalent in Asia. Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267739PMC

Body fluids may contribute to human-to-human transmission of severe acute respiratory syndrome coronavirus 2: evidence and practical experience.

Chin Med 2020 5;15:58. Epub 2020 Jun 5.

Digestive Endoscopy Center, The Affiliated Hospital of North Sichuan Medical College, Road Wenhua 63#, Region Shunqing, Nanchong, Sichuan 637000 China.

Background: In December 2019, an unbelievable outbreak of pneumonia associated with coronavirus was reported in the city of Wuhan, Hubei Province. This virus was called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although much effort has been spent on clarifying the transmission route of SARS-CoV-2, but, very little evidence is available regarding the relationship between human body fluids and transmission of SARS-CoV-2 virus. Read More

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http://dx.doi.org/10.1186/s13020-020-00337-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273816PMC
June 2020
2.343 Impact Factor

Serum and fecal profiles of aromatic microbial metabolites reflect gut microbiota disruption in critically ill patients: a prospective observational pilot study.

Crit Care 2020 06 8;24(1):312. Epub 2020 Jun 8.

Atlas Biomed Group - Knomics LLC, 31 Malaya Nikitskaya str., Moscow, Russia, 121069.

Background: High serum levels of certain aromatic microbial metabolites (AMM) are associated with severity and mortality in critically ill patients. Omics-based studies suggest gut dysbiosis and reduced microbiome diversity in critical conditions. However, the landscape of gut microbial metabolites is still to be outlined, not to mention the interplay correlation between the metabolome and gut microbiome in critically ill patients. Read More

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http://dx.doi.org/10.1186/s13054-020-03031-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278238PMC

Exoenzyme Y Contributes to End-Organ Dysfunction Caused by Pneumonia in Critically Ill Patients: An Exploratory Study.

Toxins (Basel) 2020 Jun 4;12(6). Epub 2020 Jun 4.

Department of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

is an opportunistic pathogen that causes pneumonia in immunocompromised and intensive care unit (ICU) patients. During host infection, upregulates the type III secretion system (T3SS), which is used to intoxicate host cells with exoenzyme (Exo) virulence factors. Of the four known Exo virulence factors (U, S, T and Y), ExoU has been shown in prior studies to associate with high mortality rates. Read More

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http://dx.doi.org/10.3390/toxins12060369DOI Listing

COVID-19 in lung transplant recipients: A case series from Milan, Italy.

Transpl Infect Dis 2020 Jun 8:e13356. Epub 2020 Jun 8.

Respiratory Unit and Adult Cystic, Fibrosis Centre, Internal Medicine Department, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Milano, Italy.

Limited data are currently available regarding the course of COVID-19 in lung and solid organ transplant recipients. We hereby present four cases of SARS-CoV-2 pneumonia in lung transplant recipients from our center, set in Milan, Italy. We reduced immunosuppressive regimen in all these patients, typically holding the antiproliferative agent and augmenting steroids; everybody received hydroxychloroquine, initial empiric antibiotic treatment with piperacillin/tazobactam, and high-dose low molecular weight heparin. Read More

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http://dx.doi.org/10.1111/tid.13356DOI Listing

Modeling the impact of mass influenza vaccination and public health interventions on COVID-19 epidemics with limited detection capability.

Math Biosci 2020 07 16;325:108378. Epub 2020 May 16.

Laboratory for Industrial and Applied Mathematics, Department of Mathematics and Statistics, York University, Toronto, Ontario, Canada. Electronic address:

The emerging coronavirus SARS-CoV-2 has caused a COVID-19 pandemic. SARS-CoV-2 causes a generally mild, but sometimes severe and even life-threatening infection, known as COVID-19. Currently, there exist no effective vaccines or drugs and, as such, global public authorities have so far relied upon non pharmaceutical interventions (NPIs). Read More

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http://dx.doi.org/10.1016/j.mbs.2020.108378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229764PMC

National Clinical Guidance for the Management of Cardiovascular Intervention in the COVID-19 Pandemic: From Bangladesh Society of Cardiovascular Interventions (BSCI).

Mymensingh Med J 2020 Apr;29(2):488-494

Professor MG Azam, National Institute of Cardiovascular Diseases, Dhaka, Bangladesh; E-mail:

Since the first recorded case of SARS-CoV-2 in Bangladesh on 8th March 2020, COVID-19 has spread widely through different regions of the country, resulting in a necessity to re-evaluate the delivery of cardiovascular services, particularly procedures pertaining to interventional cardiology in resource-limited settings. Given its robust capacity for human-to-human transmission and potential of being a nosocomial source of infection, the disease has specific implications on healthcare systems and health care professionals faced with performing essential cardiac procedures in patients with a suspected or confirmed diagnosis of COVID-19. The limited resources in terms of cardiac catheterization laboratories that can be designated to treat only COVID positive patients are further compounded by the additional challenges of unavailability of widespread rapid testing on-site at tertiary cardiac hospitals in Bangladesh. Read More

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Incidence of and risk factors for surgical site infection after colorectal surgery: a multiple-center prospective study of 3,663 consecutive patients in China.

Int J Infect Dis 2020 Jun 4. Epub 2020 Jun 4.

Department of Laboratory, Guangdong Provincial People's Hospital & Guangdong Academy of Medical Sciences, Guangzhou, China; Guangdong Nosocomial Infection Control and Quality Improvement Center, China. Electronic address:

Background: Surgical site infection (SSI) after colorectal surgery (CRS) remains a significant problem for its negative clinical outcomes. However, it is poorly understood in China. This study aims to investigate the incidence, risk factors and microbiology of SSI after CRS. Read More

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http://dx.doi.org/10.1016/j.ijid.2020.05.124DOI Listing

The challenge of ventilator-associated pneumonia diagnosis in COVID-19 patients.

Crit Care 2020 06 5;24(1):289. Epub 2020 Jun 5.

Intensive Care Unit, Hôpital La Pitié-Salpétrière, APHP-Sorbonne Université, Paris, France.

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http://dx.doi.org/10.1186/s13054-020-03013-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273812PMC

Chinese Society of Interventional Radiology Expert Consensus on the prevention and control of COVID-19 in interventional radiology procedures (first edition).

Quant Imaging Med Surg 2020 May;10(5):1045-1057

Department of Radiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.

The COVID-19 pandemic seriously threatens the lives of the general public and poses momentous challenges to all medical workers, including those engaged in interventional radiology, who play an important role in the diagnosis and treatment of various diseases. To further standardize the prevention and control of nosocomial infections and ensure the safety of doctors and patients, the Chinese Society of Interventional Radiology (CSIR) organized multidisciplinary experts in the field of interventional radiology in China to prepare an "Expert Consensus" elaborating and summarizing the protective strategies and suggestions for medical workers in the field of interventional radiology when they engage in interventional diagnosis and treatment activities against the background of novel coronavirus infection control. The aim is to provide a reference for interventional procedures in hospitals and other medical institutions at all levels in China and worldwide. Read More

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http://dx.doi.org/10.21037/qims.2020.04.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242296PMC

The prevalence of suspected ventilator-associated pneumonia in Scottish intensive care units.

J Intensive Care Soc 2020 May 12;21(2):140-147. Epub 2019 Jun 12.

Queen Elizabeth University Hospital, Glasgow, UK.

Ventilator-associated pneumonia is the most common healthcare-associated infection in mechanically ventilated patients. Despite this, accurate diagnosis of ventilator-associated pneumonia is difficult owing to the variety of criteria that exist. In this prospective national audit, we aim to quantify the existence of patients with suspected ventilator-associated pneumonia that would not be detected by our standard healthcare-associated infection screening process. Read More

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http://dx.doi.org/10.1177/1751143719854984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238468PMC

"Hot Zones" for Otolaryngologists: Assessing the geographic distribution of aerosol-generating procedures amidst the COVID-19 pandemic.

Am J Otolaryngol 2020 Jul - Aug;41(4):102550. Epub 2020 May 27.

Case Western Reserve University School of Medicine, Cleveland, OH, USA; Department of Otolaryngology-Head and Neck Surgery, University Hospitals Cleveland Medical Center, Cleveland, OH, USA. Electronic address:

Objective: Given high COVID-19 viral load and aerosolization in the head and neck, otolaryngologists are subject to uniquely elevated viral exposure in most of their inpatient and outpatient procedures and interventions. While elective activity has halted across the board nationally, the slow plateau of COVID-19 case rates prompts the question of timing of resumption of clinical activity. We sought to prospectively predict geographical "hot zones" for otolaryngological exposure to COVID-19 based on procedural volumes data from 2013 to 2017. Read More

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http://dx.doi.org/10.1016/j.amjoto.2020.102550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251363PMC

Fatal fulminant community-acquired pneumonia caused by hypervirulent Klebsiella pneumoniae K2-ST86: Case report.

Medicine (Baltimore) 2020 May;99(21):e20360

Department of Bacteriology, Nagoya University Graduate School of Medicine, Aichi, Japan.

Rationale: Invasive community-acquired infections, including pyogenic liver abscesses, caused by hypervirulent Klebsiella pneumoniae (hvKp) strains have been well recognized worldwide. Among these, sporadic hvKp-related community-acquired pneumonia (CAP) is an acute-onset, rapidly progressing disease that can likely turn fatal, if left untreated. However, the clinical diagnosis of hvKp infection remains challenging due to its non-specific symptoms, lack of awareness regarding this disease, and no consensus definition of hvKp. Read More

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http://dx.doi.org/10.1097/MD.0000000000020360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249946PMC

The potential transmission of SARS-CoV-2 from patients with negative RT-PCR swab tests to others: two related clusters of COVID-19 outbreak.

Jpn J Infect Dis 2020 May 29. Epub 2020 May 29.

Department of Clinical Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology.

In December 2019, a cluster of cases of acute respiratory illness, novel coronavirusinfected pneumonia, occurred in Wuhan, Hubei Province, China. The false-negative nasopharyngeal swabs of SARS-CoV-2 caused the delayed diagnosis of COVID-19 which hindered the prevention and control of the pandemic. The transmission risk of SARS-CoV-2 in negative nasopharyngeal swabs cases were little addressed previously. Read More

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http://dx.doi.org/10.7883/yoken.JJID.2020.165DOI Listing
May 2020
1.204 Impact Factor