6,890 results match your criteria Pneumonia Mycoplasma


Benefits and risks of therapeutic alternatives for macrolide resistant Mycoplasma Pneumoniae pneumonia in children.

Authors:
Hyeon-Jong Yang

Korean J Pediatr 2019 Mar 15. Epub 2019 Mar 15.

Pediatric Allergy and Respiratory Center, Department of Pediatrics, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, Korea.

Mycoplasma pneumoniae pneumonia (MPP) has been generally susceptible to macrolides, however emergence of macrolide-resistant Mycoplasma pneumoniae pneumonia (MRMP) has made the treatment of MPP challenging. MRMP rapidly spread after 2000s, especially in the Eastern Asia. MRMPs are more common in children and adolescents than in adults, which is likely related to the frequent use of macrolides for treatments of MP infections in children. Read More

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http://dx.doi.org/10.3345/kjp.2018.07367DOI Listing

Cathepsin L promotes secretory IgA response by participating in antigen presentation pathways during Mycoplasma Hyopneumoniae infection.

PLoS One 2019 15;14(4):e0215408. Epub 2019 Apr 15.

Department of Veterinary Public Health Safety and Management, Chinese Academy of Agricultural Sciences, Beijing, China.

Cathepsin L (CTSL) has been proved to help contain leishmaniasis and mycoplasma infection in mice by supporting cellular immune responses, but the regulatory functions of CTSL on mucosal immune responses haven't been tested and remain undefined. Here, we investigated the effects of CTSL on SIgA responses and invariant chain (Ii) degradations in the co-cultured swine dendritic cells (DCs) and B cells system in vitro. When the cells system were transfected with vector CTSL-GFP or incubated with recombinant CTSL (rCTSL) before they were infected with Mycoplasma hyopneumoniae (M. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215408PLOS
April 2019
1 Read

The Clinical Presentation of Pediatric Mycoplasma pneumoniae Infections-A Single Center Cohort.

Pediatr Infect Dis J 2019 Apr 10. Epub 2019 Apr 10.

From the Department of Clinical Microbiology and Infectious Diseases, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

Background: Mycoplasma pneumoniae (MP) is a major cause of community-acquired upper and lower respiratory infections in school-age children; however, there is increasing recognition that younger children are also affected. Clinical manifestations vary from asymptomatic, to severe complicated pneumonia sometimes with extrapulmonary manifestations.

Methods: We reviewed the medical records of all MP positive pediatric patients admitted to the Hadassah-Hebrew University Medical Center. Read More

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http://dx.doi.org/10.1097/INF.0000000000002291DOI Listing
April 2019
3 Reads

Disulfide bond of Mycoplasma pneumoniae community acquired respiratory distress syndrome toxin is essential to maintain the ADP-ribosylating and vacuolating activities.

Cell Microbiol 2019 Apr 11:e13032. Epub 2019 Apr 11.

Department of Microbiology, Immunology and Molecular Genetics, The University of Texas Health Science Center at San Antonio, TX.

Mycoplasma pneumoniae is the leading cause of bacterial community acquired pneumonia among hospitalized children in United States and worldwide. Community acquired respiratory distress syndrome (CARDS) toxin is a key virulence determinant of M. pneumoniae. Read More

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http://dx.doi.org/10.1111/cmi.13032DOI Listing
April 2019
1 Read

Epidemiological relationship between pneumonia and recurrent wheezing episode in children: an observational study at a single hospital in Korea.

BMJ Open 2019 Apr 11;9(4):e026461. Epub 2019 Apr 11.

Department of Paediatrics, College of Medicne, The Catholic University of Kora, Seoul, Republic of Korea.

Objective: This study was aimed to evaluate epidemiological and clinical relationship between (MP) infection and childhood recurrent wheezing episode (RWE).

Design: Retrospective case note review.

Setting: Paediatric department at a single Korean institution. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026461DOI Listing
April 2019
1 Read

Evaluation of the ELITe InGenius PCR for Detection of .

J Clin Microbiol 2019 Apr 10. Epub 2019 Apr 10.

Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA

, Mpn, is the leading cause of bacterial community acquired pneumonia in persons of all ages. Due to the fastidious nature of this bacteria and the necessary specialized growth media, nucleic acid amplification testing is currently the most reliable means for patient diagnostics. Analytical sensitivity, specificity, reproducibility, and clinical performance of the ELITe InGenius automated PCR platform with its MGB Alert Real-Time PCR research use only reagents (ELITechGroup, Inc. Read More

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http://jcm.asm.org/lookup/doi/10.1128/JCM.00287-19
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http://dx.doi.org/10.1128/JCM.00287-19DOI Listing
April 2019
4 Reads

Characterization of Mycoplasma hyopneumoniae strains in vaccinated and non-vaccinated pigs from Spanish slaughterhouses.

Vet Microbiol 2019 Apr 20;231:18-23. Epub 2019 Feb 20.

IRTA, Centre de Recerca en Sanitat Animal (CRESA, IRTA-UAB), Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain. Electronic address:

This study aimed to describe Mycoplasma hyopneumoniae (M. hyopneumoniae) genetic variability in vaccinated (V) and non-vaccinated (NV) slaughtered pigs showing cranio-ventral pulmonary consolidation (CVPC). Ten V and 10 NV fattening farms with respiratory problems associated to M. Read More

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http://dx.doi.org/10.1016/j.vetmic.2019.02.023DOI Listing
April 2019
1 Read

Characterisation of the course of Mycoplasma bovis infection in naturally infected dairy herds.

Vet Microbiol 2019 Apr 9;231:107-115. Epub 2019 Mar 9.

Veterinary Bacteriology and Pathology, Research and Laboratory Division, Finnish Food Authority, Neulaniementie 4, 70210 Kuopio, Finland.

Mycoplasma bovis causes bovine respiratory disease, mastitis, arthritis and otitis. The importance of M. bovis has escalated because of recent outbreaks and introductions into countries previously free of M. Read More

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http://dx.doi.org/10.1016/j.vetmic.2019.03.007DOI Listing
April 2019
3 Reads

Mycoplasma Pneumonia: Late Treatment Leading to Acute Respiratory Distress Syndrome and Renal Failure.

Eur J Case Rep Intern Med 2019 13;6(2):001003. Epub 2019 Feb 13.

Wexford General Hospital, Wexford, Ireland.

Introduction: Mycoplasma pneumonia is one of the most common types of pneumonia, although it is often not diagnosed due to mild clinical course.

Aims: In this case study we aim to describe the importance of considering mycoplasma pneumonia in high-risk groups.

Methods: We present the case of a 27-year-old woman admitted with pneumonia, progressing to acute respiratory distress syndrome and acute kidney injury. Read More

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https://www.ejcrim.com/index.php/EJCRIM/article/view/1003
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http://dx.doi.org/10.12890/2019_001003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432824PMC
February 2019
3 Reads

Molecular characterization and analysis of Mycoplasma pneumoniae among patients of all age with community-acquired pneumonia during an epidemic in China.

Int J Infect Dis 2019 Mar 26. Epub 2019 Mar 26.

Department of Respiratory and Critical Care Medicine, Clinical Microbiology and Infectious Disease Lab, China-Japan Friendship Hospital, Beijing, China.

Background: Analysis of the molecular characteristics of isolates is very important for clinical and epidemiological study of community-acquired pneumonia (CAP) caused by M. pneumoniae.

Methods: Between 2010 and 2012, an epidemic period, M. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.03.028DOI Listing
March 2019
1 Read

Impact of atopy on the severity and extrapulmonary manifestations of childhood Mycoplasma pneumoniae pneumonia.

J Clin Lab Anal 2019 Mar 29:e22887. Epub 2019 Mar 29.

Department of Pediatrics, Tianjin Hospital of Integrated Traditional Chinese and Western Medicine, Tianjin Nankai Hospital, Tianjin, China.

Objectives: The impact of atopy on disease severity and extrapulmonary manifestations in children with Mycoplasma pneumoniae (MP) pneumonia is unknown.

Methods: Patients diagnosed with MP pneumonia between January 2016, and December 2017, were enrolled in this study. A total of 150 MP pneumonia patients were enrolled at diagnosis and divided into the atopic group (n = 48) and the nonatopic group (n = 102). Read More

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http://dx.doi.org/10.1002/jcla.22887DOI Listing
March 2019
1 Read

Rapid resolution of reversible bronchiectasis after Mycoplasma pneumoniae pneumonia in an adult: A case report.

Authors:
Qi Guo Hai-Yan Li

Medicine (Baltimore) 2019 Mar;98(13):e15048

Medical Department, The Eighth Affiliated Hospital (Shenzhen Futian), Sun Yat-sen University, Shenzhen, Guangdong, China.

Rationale: Bronchiectasis results when inflammatory and infectious damage to the bronchial and bronchiolar walls leads to a vicious cycle of airway injury. On the basis of the classic characteristic, that is, permanent bronchial dilatation, bronchiectasis is generally considered irreversible in the adult population.

Patient Concerns: A 21-year-old woman presented to our hospital with a 9-day history of productive cough and fever. Read More

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http://dx.doi.org/10.1097/MD.0000000000015048DOI Listing
March 2019
1 Read

Lower Respiratory Tract Microbiome and Resistome of Bovine Respiratory Disease Mortalities.

Microb Ecol 2019 Mar 27. Epub 2019 Mar 27.

Lethbridge Research and Development Centre, Agriculture and Agri-Food Canada, Lethbridge, Alberta, Canada.

Bovine respiratory disease (BRD) continues to be a serious health problem in beef cattle production. A multifactorial condition, BRD encompasses several types of pneumonia that are associated with multiple viral and bacterial agents. Comprehensive identification of microbes associated with BRD fatalities could enhance our understanding of the range of pathogens that contribute to the disease and identify new therapeutic targets. Read More

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http://dx.doi.org/10.1007/s00248-019-01361-3DOI Listing
March 2019
1 Read

Molecular typing of strains in Sweden, 1996-2017, and the emergence of a new P1 cytadhesin gene, Variant 2e.

J Clin Microbiol 2019 Mar 27. Epub 2019 Mar 27.

Department of Medical Sciences, Section of Clinical Microbiology and Infectious Diseases, Uppsala University, Uppsala, Sweden.

causes respiratory infections, such as community-acquired pneumonia (CAP), with epidemics recurring every 3-7 years. In 2010-2011, many countries experienced an extraordinary epidemic peak. The cause of these recurring epidemics is not understood, but decreasing herd immunity and shifts in the strains' antigenic properties have been suggested as contributing factors. Read More

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http://dx.doi.org/10.1128/JCM.00049-19DOI Listing
March 2019
3 Reads

Intra-Species and Inter-Species Differences in Cytokine Production by Porcine Antigen-Presenting Cells Stimulated by , , and .

Pathogens 2019 Mar 16;8(1). Epub 2019 Mar 16.

Swine and Poultry Infectious Diseases Research Center and Research Group on Infectious Diseases in Production Animals, Faculty of Veterinary Medicine, University of Montreal, 3200 Sicotte St., Saint-Hyacinthe, QC J2S 2M2, Canada.

and are commonly co-isolated with (primary agent of swine enzootic pneumonia) in gross pneumonia-like lesions, but their involvement in the disease process remains unknown. T cells play an immuno-pathological role during mycoplasmal infections. Dendritic cells (DCs) are major antigen-presenting cells involved in T cell activation and differentiation. Read More

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http://dx.doi.org/10.3390/pathogens8010034DOI Listing
March 2019
1 Read

Epidemiology and mechanism of drug resistance of Mycoplasma pneumoniae in Beijing, China: A multi-center study.

Bosn J Basic Med Sci 2019 Mar 17. Epub 2019 Mar 17.

Beijing Key Laboratory for Research on Prevention and Treatment of Tropical Diseases, Beijing Tropical Medicine Research Institute, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Mycoplasma pneumoniae (M. pneumoniae) is one of the most common causes of community-acquired respiratory tract infections (RTIs). We aimed to investigate the prevalence of M. Read More

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http://dx.doi.org/10.17305/bjbms.2019.4053DOI Listing
March 2019
2 Reads

Comparison of Indirect Immunofluorescence and Passive Particle Agglutination for the Detection of Mycoplasma Pneumoniae Antibodies.

Clin Lab 2019 Mar;65(3)

Background: Mycoplasma pneumoniae (MP) is the most predominant pathogen causing pneumonia. The present study compares two serological assays, the indirect immunofluorescence assay (IFA) and the passive particle agglutination assay (PPA), in order to assist clinicians in selecting accurate diagnosis methods.

Methods: Sera from 127 patients suffering from mycoplasma pneumonia and 76 from the healthy group were analyzed simultaneously by PPA and IFA. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180901DOI Listing

Differential responses to stress of two Mycoplasma hyopneumoniae strains.

J Proteomics 2019 May 9;199:67-76. Epub 2019 Mar 9.

Laboratório de Genômica Estrutural e Funcional, Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Avenida Bento Gonçalves, Porto Alegre, Rio Grande do Sul 9500, Brazil. Electronic address:

Mycoplasma hyopneumoniae is a respiratory pathogen, causing porcine enzootic pneumonia. To survive in the porcine respiratory tract, M. hyopneumoniae must cope with both oxidative and heat stress imposed by the host. Read More

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http://dx.doi.org/10.1016/j.jprot.2019.03.006DOI Listing
May 2019
2 Reads

Mycoplasma pneumonia with hydropneumothorax: A case report.

Respir Med Case Rep 2019 22;26:299-300. Epub 2019 Feb 22.

Oakhill Hospital, Brooksville, FL, USA.

Mycoplasma pneumoniae is one of the most common causes of community-acquired pneumonia in adults. Mycoplasma pneumoniae pneumonia (MPP) presents with pulmonary and extrapulmonary manifestations. Pneumothorax is a rare MPP complication in children. Read More

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http://dx.doi.org/10.1016/j.rmcr.2019.02.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396097PMC
February 2019
1 Read

Outcomes From Using Mortality, Antimicrobial Consumption, and Vaccine Use Data for Monitoring Endemic Diseases in Danish Swine Herds.

Front Vet Sci 2019 22;6:41. Epub 2019 Feb 22.

Division for Diagnostics and Scientific Advice-Epidemiology, National Veterinary Institute/Center for Diagnostics, Technical University of Denmark, Kongens Lyngby, Denmark.

The aim of this study was to assess the potential of using multiple data sources currently available in Denmark for monitoring swine diseases. The study included farms that, based on serology, changed from "negative" to "positive" status for Porcine Reproductive and Respiratory Syndrome (PRRS), enzootic pneumonia (), and porcine pleuropneumonia () between January 2014 and September 2017. These corresponded to 45 swine farms working as individual operation units (i. Read More

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http://dx.doi.org/10.3389/fvets.2019.00041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395435PMC
February 2019
1 Read

An outbreak of Mycoplasma mycoides subspecies capri arthritis in young goats: a case study.

J Vet Diagn Invest 2019 Mar 11:1040638719835243. Epub 2019 Mar 11.

Departments of Veterinary Pathobiology (Johnson, Fales, Williams, Zinn, Mitchell, Calcutt), University of Missouri, Columbia, MO.

Mycoplasmosis is a well-known cause of morbidity and mortality in small ruminants. Previously recognized outbreaks have involved arthritis, and pneumonia or pleuropneumonia. Modern bacteriology procedures rely less on isolation techniques that require special media for mollicutes given that these species are notoriously difficult to isolate, and rely more on PCR tests. Read More

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http://journals.sagepub.com/doi/10.1177/1040638719835243
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http://dx.doi.org/10.1177/1040638719835243DOI Listing
March 2019
7 Reads

Analysis of swine antigen-specific antibody responses to Mycoplasma hyopneumoniae infection determined by protein microarray.

Vet Microbiol 2019 Mar 5;230:195-201. Epub 2019 Feb 5.

Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011-1134, USA. Electronic address:

Pigs harbor several different species of mycoplasmas, of which Mycoplasma hyopneumoniae presents the most significant economic impact on the swine industry. While ELISAs are the predominant diagnostic assay to measure antibody responses during infection with M. hyopneumoniae, the assay itself is only a rough estimate of the total antibody response. Read More

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http://dx.doi.org/10.1016/j.vetmic.2019.02.010DOI Listing
March 2019
3 Reads

An adult case of severe life-threatening Mycoplasma pneumoniae pneumonia due to a macrolide-resistant strain, Japan: a case report.

BMC Infect Dis 2019 Feb 28;19(1):204. Epub 2019 Feb 28.

Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Background: Until now, the prevalence of macrolide-resistant Mycoplasma pneumoniae (MP) infection among adult patients has been low, and severe MP pneumonia due to a macrolide-resistant strain has seldom been reported. Here, we describe a rare case of severe life-threatening MP pneumonia due to a macrolide-resistant strain in an adult, which was finally treated with fluoroquinolone and tetracycline after failed treatment with macrolide and corticosteroid.

Case Presentation: A 39-year-old apparently healthy woman complained of fever and productive cough. Read More

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http://dx.doi.org/10.1186/s12879-019-3846-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396484PMC
February 2019
4 Reads

Rapid and sensitive detection of Mycoplasma hyopneumoniae by recombinase polymerase amplification assay.

J Microbiol Methods 2019 Apr 23;159:56-61. Epub 2019 Feb 23.

College of Veterinary Medicine, Agricultural University of Hebei, Baoding 071001, China. Electronic address:

Mycoplasma hyopneumoniae is the etiological agent of swine enzootic pneumonia, which is associated with high economic losses in swine production worldwide. In this study, recombinase polymerase amplification assays using real-time fluorescence detection (real-time RPA) and lateral flow strip detection (LFS RPA) were developed to detect M. hyopneumoniae based on the conserved region of the mhp165 gene. Read More

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http://dx.doi.org/10.1016/j.mimet.2019.02.015DOI Listing
April 2019
1 Read

[Virus and Atypical Pathogens Detected in Community-Acquired Lower Respiratory Tract Infection in Infants and Children of Sfax Region, Tunisia].

Bull Soc Pathol Exot 2018 ;111(2):90-98

Laboratoire de microbiologie, faculté de médecine de Sfax, université de Sfax, Tunisie.

Little is known about viral and atypical bacteria pathogen spectra of community-acquired lower respiratory tract infection in children in Tunisia. Thus, a prospective study was carried out between January 2009 and March 2010 in Sfax. Nasopharyngeal aspirates collected from 368 patients (78 with pneumonia and 290 with acute bronchiolitis) were analyzed by indirect immunofluorescence assay and PCR to detect influenza viruses, parainfluenza viruses, respiratory syncytial virus (RSV), human metapneumovirus, human rhinovirus, human enterovirus, adenovirus, coronavirus, (Mpn) and (Cpn). Read More

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http://dx.doi.org/10.3166/bspe-2018-0024DOI Listing
January 2018
3 Reads

[Clinical features of nephrotic syndrome accompanied by eosinophilia in children].

Zhongguo Dang Dai Er Ke Za Zhi 2019 Feb;21(2):165-167

Department of Nephrology, Tianjin Children's Hospital, Tianjin 300134, China.

Objective: To study the clinical features of nephrotic syndrome (NS) accompanied by eosinophilia in children.

Methods: A retrospective analysis was performed for the clinical manifestations, laboratory findings and treatment outcomes of 18 cases of eosinophilia (15 children, 3 of whom also had eosinophilia at the second recurrence) in children with NS.

Results: Of the 18 cases, 16 (89%) had mild eosinophilia, 1 (6%) had moderate eosinophilia, and 1 (6%) had severe eosinophilia. Read More

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February 2019
10 Reads

[Correlation between galectin-3 level in bronchoalveolar lavage fluid and cellular immunity in children with refractory Mycoplasma pneumoniae pneumonia].

Zhongguo Dang Dai Er Ke Za Zhi 2019 Feb;21(2):150-154

Department of Pediatrics, Lianyungang Maternal and Child Health Care Center Affiliated to Yangzhou University, Lianyungang, Jiangsu 222006, China.

Objective: To study the correlation of galectin-3 level in bronchoalveolar lavage fluid (BALF) with Mycoplasma pneumoniae (MP) load and cellular immunity of neutrophils and macrophages in the airway in children with refractory MP pneumonia (RMPP).

Methods: A total of 64 children with RMPP who were hospitalized from January 2013 to January 2017 were enrolled. In addition to the conservative medical treatment, all the 64 children with RMPP were given bronchoalveolar lavage in the acute stage (5-7 days after admission) and 48 out of the 64 children were given bronchoalveolar lavage in the recovery stage (10-14 days after admission). Read More

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February 2019
1 Read

[Pathogens in bronchoalveolar lavage fluid of children with lower respiratory tract infection].

Zhongguo Dang Dai Er Ke Za Zhi 2019 Feb;21(2):144-149

Department of Pediatrics, Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

Objective: To study the features of pathogens in children with lower respiratory tract infection.

Methods: A total of 108 children who were hospitalized due to lower respiratory tract infection and underwent fiber bronchoscopy between January 2017 and June 2018 were enrolled. Bronchoalveolar lavage fluid samples were collected. Read More

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February 2019
9 Reads

Diagnosis of mycoplasma pneumoniae by loop-mediated isothermal amplification: systematic review and meta-analysis.

BMC Infect Dis 2019 Feb 19;19(1):173. Epub 2019 Feb 19.

Department of Clinical Laboratory Medicine, the Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.

Background: A novel method, termed loop-mediated isothermal amplification (LAMP), was developed by Notomi et al. (2000). Individually published results have been reported that this technology has been successfully applied to the detection of a variety of pathogens. Read More

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http://dx.doi.org/10.1186/s12879-019-3799-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379949PMC
February 2019
2 Reads

arthritis and pneumonia in calves in Jordan: An emerging disease.

Vet World 2018 Dec 12;11(12):1663-1668. Epub 2018 Dec 12.

Department of Veterinary Clinical Sciences, Faculty of Veterinary Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan.

Aim: Clinical, microbiological, molecular, and pathological assays were undertaken to characterize an outbreak of increasingly reported signs of unresponsive arthritis and pneumonia of infection in young calves in Jordan.

Materials And Methods: Clinical history of the affected bovine herd was investigated for the presence of respiratory and/or joint problems. Two calves with such history were clinically examined and necropsied. Read More

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http://www.veterinaryworld.org/Vol.11/December-2018/3.html
Publisher Site
http://dx.doi.org/10.14202/vetworld.2018.1663-1668DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362338PMC
December 2018
8 Reads

Mycoplasma ovipneumoniae Associated with Polymicrobial Pneumonia in a Free-Ranging Yearling Barren Ground Caribou ( Rangifer tarandus granti) from Alaska, USA.

J Wildl Dis 2019 Feb 15. Epub 2019 Feb 15.

2 US Department of Agriculture, Agricultural Research Services, Animal Disease Research Unit, Washington State University, ADBF 3003, Pullman, Washington 99164, USA.

Mycoplasma ovipneumoniae has been reported in association with respiratory disease only in members of the subfamily Caprinae of the family Bovidae. We identified Mycoplasma ovipneumoniae in a cervid: a free-ranging barren ground caribou ( Rangifer tarandus granti) yearling with polymicrobial bronchopneumonia. Read More

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February 2019

-associated Mucositis: A Recently Described Entity.

Eur J Case Rep Intern Med 2018 28;5(11):000977. Epub 2018 Nov 28.

Internal Medicine Department, Centro Hospitalar do Baixo Vouga, Aveiro, Portugal.

(MP) is a common cause of respiratory infections and can be associated with extrapulmonary complications. MP mucositis has recently been described as a distinct endemic clinical entity called e-induced rash and mucositis (MIRM). The authors present the case of a 46-year-old man with atypical pneumonia associated with exuberant mucositis, conjunctival hyperaemia and positive serological assays for MP IgM. Read More

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http://dx.doi.org/10.12890/2018_000977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346809PMC
November 2018
1 Read

HDAC5 promotes Mycoplasma pneumoniae-induced inflammation in macrophages through NF-κB activation.

Life Sci 2019 Mar 6;221:13-19. Epub 2019 Feb 6.

Department of Paediatrics, First Subsidiary Hospital, University of Science and Technology of He'nan, 471000, China.

Excessive inflammation is fundamental in the pathophysiology of Mycoplasma pneumoniae (MP)-induced respiratory infection in children. Histone deacetylase 5 (HDAC5) is involved in the regulation of inflammation, however, whether it associates with immunity against MP infection is not determined. We report here that HDAC5 expression is decreased in peripheral blood mononuclear cells (PBMCs) from Mycoplasma pneumoniae pneumonia (MPP) children as well as in MP-infected peritoneal and THP-1 macrophages. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.02.004DOI Listing
March 2019
1 Read

A pilot study of the effects of Mycoplasma ovipneumoniae exposure on domestic lamb growth and performance.

PLoS One 2019 7;14(2):e0207420. Epub 2019 Feb 7.

Department of Animal Sciences, Washington State University College of Agricultural, Human, and Natural Resource Sciences, Pullman WA, United States of America.

Mycoplasma ovipneumoniae is a globally distributed pathogen that has been associated with pneumonia in both domestic and wild Caprinae. It is closely related to M. hyopneumoniae, a respiratory pathogen of swine that is associated with decreased growth rates of pigs as well as clinical respiratory disease. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207420PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366759PMC
February 2019
1 Read

Comparison of high-dose and low-dose corticosteroid therapy for refractory Mycoplasma pneumoniae pneumonia in children.

J Infect Chemother 2019 May 2;25(5):346-350. Epub 2019 Feb 2.

Department of Pediatrics, Nagoya University Graduate School of Medicine, Japan; Division of Neonatology, Center for Maternal-Neonatal Care, Nagoya University Hospital, Japan.

Background: Mycoplasma pneumoniae pneumonia (MPP) is generally a self-limiting disease, but it may become refractory. It is thought that refractory MPP is linked to the excessive immunologic responses of the host. Consequently, the use of adjunctive systemic corticosteroids may have beneficial effects. Read More

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http://dx.doi.org/10.1016/j.jiac.2019.01.003DOI Listing
May 2019
3 Reads

The use of multiplex PCR for the detection of atypical pathogens in Egyptian children with CAP: a high rate of in early infancy.

J Egypt Public Health Assoc 2019 18;94(1). Epub 2019 Jan 18.

2Department of Clinical Pathology, Faculty of Medicine, Cairo University, 2 Atteia Abd El Hadi St., El Maadi, Cairo, 11562 Egypt.

Background: Atypical pathogen infections played an important role in community-acquired pneumonia (CAP) in children. Pathogen-specific clinical symptoms are often lacking, and it is difficult to detect atypical pathogens by culture methods. The use of multiplex polymerase chain reaction (PCR) methods enables testing for many pathogens simultaneously in a single analysis. Read More

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http://dx.doi.org/10.1186/s42506-018-0003-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338716PMC
April 2019
9 Reads

Case 4: Altered Mental Status in a 6-year-old Boy.

Pediatr Rev 2019 Feb;40(2):88-89

Division of Emergency Medicine, Department of Pediatrics, Kings County Medical Center, Brooklyn, NY.

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http://dx.doi.org/10.1542/pir.2016-0190DOI Listing
February 2019
1 Read

Mycoplasma Pneumoniae Pericarditis.

Am J Cardiol 2019 Apr 24;123(8):1383-1384. Epub 2019 Jan 24.

Section of Cardiovascular Medicine, Department of Internal Medicine, School of Medicine, Yale University, New Haven, Connecticut. Electronic address:

Mycoplasma pneumoniae is an atypical bacterium that is frequently implicated in respiratory infections, but uncommonly identified as a cause of pericarditis. We report 2 cases of pericarditis attributed to M. pneumoniae that were characterized by prolonged respiratory prodromes, pericardial, and pleural effusions, elevated inflammatory markers, and relapsing clinical courses. Read More

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http://dx.doi.org/10.1016/j.amjcard.2019.01.014DOI Listing
April 2019
1 Read

Loop-mediated isothermal amplification-lateral-flow dipstick (LAMP-LFD) to detect Mycoplasma ovipneumoniae.

World J Microbiol Biotechnol 2019 Jan 30;35(2):31. Epub 2019 Jan 30.

College of Life Sciences, Shihezi University, Xin Jiang, Shihezi, 832000, China.

In order to establish a rapid detection method for Mycoplasma ovipneumoniae, this study used the loop-mediated isothermal amplification (LAMP) technique to carry out nucleic acid amplification and chromatographic visualization via a lateral flow dipstick (LFD) assay. The M. ovipneumoniae elongation factor TU gene (EF-TU) was detected using a set of specific primers designed for the EF-TU gene, and the EF-TU FIP was detected by biotin labeling, which was used in the LAMP amplification reaction. Read More

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http://dx.doi.org/10.1007/s11274-019-2601-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353813PMC
January 2019
2 Reads

Rapid diagnosis of Mycoplasma pneumonia infection by denaturation bubble-mediated strand exchange amplification: comparison with LAMP and real-time PCR.

Sci Rep 2019 Jan 29;9(1):896. Epub 2019 Jan 29.

College of Life Sciences, Qingdao University, Qingdao, 266071, PR China.

M. pneumoniae infection is often ignored due to its similar clinical symptom with respiratory tract infections caused by bacteria or viruses, and thus leading to misdiagnosis and delayed treatment. It is critical to develop a rapid, sensitive and specific diagnosis method. Read More

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http://dx.doi.org/10.1038/s41598-018-36751-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351683PMC
January 2019
15 Reads

Outbreak of Chlamydia pneumoniae Infections and X-ray-Confirmed Pneumonia in Army Trainees at Fort Leonard Wood, Missouri, 2014.

Mil Med 2019 Jan 23. Epub 2019 Jan 23.

US Army Public Health Center, Aberdeen Proving Ground, MD.

Introduction: Chlamydia pneumoniae (Cp) is a bacterium that causes pneumonia and other respiratory diseases. Fever may be present early but absent by time of presentation to clinic. Increases in X-ray-confirmed pneumonia (XCP) and laboratory-confirmed Cp infections were observed in new soldiers in training at Fort Leonard Wood (FLW), Missouri, early in 2014. Read More

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http://dx.doi.org/10.1093/milmed/usy402DOI Listing
January 2019
9 Reads

M. pneumoniae and C. pneumoniae are no relevant pathogens in critically ill patients with hospital-acquired respiratory tract infections.

Infection 2019 Jan 28. Epub 2019 Jan 28.

Institute for Infectious Diseases and Infection Control, Jena University Hospital, Am Klinikum 1, 07747, Jena, Germany.

Purpose: To assess the incidence of Mycoplasma pneumoniae and Chlamydia pneumoniae in the pathogenesis of hospital-acquired respiratory tract infections (RTIs) in critically ill patients.

Methods: This is a retrospective cohort study of all ICU-patients ≥ 18 years with RTI who underwent conventional culture techniques and PCR testing for both M. pneumoniae and C. Read More

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http://dx.doi.org/10.1007/s15010-019-01273-xDOI Listing
January 2019
3 Reads

Role of Probiotics in Pneumonia in Children: A Short-Term Pilot Project.

Front Microbiol 2018 9;9:3261. Epub 2019 Jan 9.

Department of Gastroenterology, Affiliated Beijing Children's Hospital, Capital Medical University, Beijing, China.

is one of the most common pathogens causing community-acquired pneumonia in children. pneumonia (MPP) can be successfully treated with azithromycin; however, antibiotic-associated diarrhea (AAD) is a common adverse effect. Increasing evidence suggests that some probiotics may prevent the development of AAD. Read More

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http://dx.doi.org/10.3389/fmicb.2018.03261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334620PMC
January 2019
3 Reads

Macrolide prescription in Dutch children: compliance with guidelines.

Eur J Clin Microbiol Infect Dis 2019 Apr 24;38(4):675-681. Epub 2019 Jan 24.

Department of Clinical Pharmacy, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands.

For reasons of antibiotic resistance and side effects, macrolides should be prescribed with care in the pediatric population. We evaluated the adherence to Dutch guidelines of macrolide prescription in children and estimated the risk of Mycoplasma pneumoniae-associated pneumonia based on Fischer's decision tree. In this retrospective study, we included children aged 0-18 years who were treated with azithromycin or clarithromycin for pulmonary disease in four settings from general practice to hospital ward for (1) the prescriptions not in accordance with the guideline of the Dutch Association of Pediatrics and (2) the risk of M. Read More

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http://dx.doi.org/10.1007/s10096-019-03473-7DOI Listing
April 2019
3 Reads

Positively interacting strains that co-circulate within a network structured population induce cycling epidemics of Mycoplasma pneumoniae.

Sci Rep 2019 Jan 24;9(1):541. Epub 2019 Jan 24.

Centre for Infectious Disease Surveillance and Control, Public Health England, London, UK.

Mycoplasma pneumoniae (MP) is considered a common cause of pneumonia, causing about 15-20% of adult community-acquired pneumonia (CAP) and up to 40% of cases in children. It has often been observed that MP epidemics last approximately 1-2 years and occur every 3-7 years, with the dominant strains alternating between epidemics. However, the underlying mechanism by which these cycles and changes in the dominant strains occur remains unclear. Read More

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http://dx.doi.org/10.1038/s41598-018-36325-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345813PMC
January 2019
3 Reads

[Epidemiological and clinical analysis of community-acquired Mycoplasma pneumonia in children from a Spanish population, 2010-2015].

An Pediatr (Barc) 2019 Jan 21. Epub 2019 Jan 21.

Servicio de Pediatría, Hospital General Universitario, Valencia, España.

Introduction And Objectives: Mycoplasma pneumoniae (MP) is one of the most common etiological agents of community-acquired pneumonia (CAP) in children. We aimed to describe the clinical and epidemiological characteristics, treatment and outcome of children diagnosed with community-acquired MP pneumonia (CAMP) in a tertiary hospital in Valencia, Spain.

Material And Methods: Medical records of children <14 years with CAMP were retrospectively reviewed from January 2010 to December 2015. Read More

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http://dx.doi.org/10.1016/j.anpedi.2018.07.016DOI Listing
January 2019
4 Reads

Changes in antimicrobial susceptibility profiles of over time.

Can J Vet Res 2019 Jan;83(1):34-41

Animal Health Laboratory, Laboratory Services (Cai, McDowall, Parker) and Department of Pathobiology (Kaufman, Caswell), University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1.

is a major cause of pneumonia, arthritis, and mastitis in cattle and can lead to significant economic losses. Antimicrobial resistance is a concern and further limits the already short list of drugs effective against mycoplasmas. The objective of this study was to examine changes in minimum inhibitory concentrations (MICs) of antimicrobials of aminoglycoside, fluoroquinolone, lincosamide, macrolide, pleuromutilin, phenicol, and tetracycline classes for 210 isolates collected from 1978 to 2009. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318825PMC
January 2019
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Identfication of viral and bacterial etiologic agents of the pertussis-like syndrome in children under 5 years old hospitalized.

BMC Infect Dis 2019 Jan 21;19(1):75. Epub 2019 Jan 21.

School of Medicine. Research and Innovation Centre of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima, Peru.

Background: Acute respiratory infections (ARIs) represent an important cause of morbidity and mortality in children, remaining a major public health concern, especially affecting children under 5 years old from low-income countries. Unfortunately, information regarding their epidemiology is still limited in Peru.

Methods: A secondary data analysis was performed from a previous cross-sectional study conducted in children with a probable diagnosis of Pertussis from January 2010 to July 2012. Read More

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http://dx.doi.org/10.1186/s12879-019-3671-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341522PMC
January 2019
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A concise review of vaccines against Mycoplasma hyopneumoniae.

Res Vet Sci 2019 Apr 9;123:144-152. Epub 2019 Jan 9.

Department of Biochemistry and Molecular Biology, College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou 310018, China. Electronic address:

Mycoplasma hyopneumoniae (Mhp) is the pathogen of Mycoplasmal pneumonia of swine (MPS), a chronic respiratory infectious discease which causes enormous losses to the swine industry worldwide. At present, vaccination is the most effective mean to prevent and reduce economic losses caused by this pathogen. Currently, MPS vaccines mainly include inactivated vaccines and attenuated live vaccines. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00345288183145
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http://dx.doi.org/10.1016/j.rvsc.2019.01.007DOI Listing
April 2019
12 Reads