6,859 results match your criteria Pneumonia Mycoplasma


[Clinical features of nephrotic syndrome accompanied by eosinophilia in children].

Zhongguo Dang Dai Er Ke Za Zhi 2019 Feb;21(2):165-167

Department of Nephrology, Tianjin Children's Hospital, Tianjin 300134, China.

Objective: To study the clinical features of nephrotic syndrome (NS) accompanied by eosinophilia in children.

Methods: A retrospective analysis was performed for the clinical manifestations, laboratory findings and treatment outcomes of 18 cases of eosinophilia (15 children, 3 of whom also had eosinophilia at the second recurrence) in children with NS.

Results: Of the 18 cases, 16 (89%) had mild eosinophilia, 1 (6%) had moderate eosinophilia, and 1 (6%) had severe eosinophilia. Read More

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February 2019
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[Correlation between galectin-3 level in bronchoalveolar lavage fluid and cellular immunity in children with refractory Mycoplasma pneumoniae pneumonia].

Zhongguo Dang Dai Er Ke Za Zhi 2019 Feb;21(2):150-154

Department of Pediatrics, Lianyungang Maternal and Child Health Care Center Affiliated to Yangzhou University, Lianyungang, Jiangsu 222006, China.

Objective: To study the correlation of galectin-3 level in bronchoalveolar lavage fluid (BALF) with Mycoplasma pneumoniae (MP) load and cellular immunity of neutrophils and macrophages in the airway in children with refractory MP pneumonia (RMPP).

Methods: A total of 64 children with RMPP who were hospitalized from January 2013 to January 2017 were enrolled. In addition to the conservative medical treatment, all the 64 children with RMPP were given bronchoalveolar lavage in the acute stage (5-7 days after admission) and 48 out of the 64 children were given bronchoalveolar lavage in the recovery stage (10-14 days after admission). Read More

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February 2019

[Pathogens in bronchoalveolar lavage fluid of children with lower respiratory tract infection].

Zhongguo Dang Dai Er Ke Za Zhi 2019 Feb;21(2):144-149

Department of Pediatrics, Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

Objective: To study the features of pathogens in children with lower respiratory tract infection.

Methods: A total of 108 children who were hospitalized due to lower respiratory tract infection and underwent fiber bronchoscopy between January 2017 and June 2018 were enrolled. Bronchoalveolar lavage fluid samples were collected. Read More

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February 2019
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Diagnosis of mycoplasma pneumoniae by loop-mediated isothermal amplification: systematic review and meta-analysis.

BMC Infect Dis 2019 Feb 19;19(1):173. Epub 2019 Feb 19.

Department of Clinical Laboratory Medicine, the Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.

Background: A novel method, termed loop-mediated isothermal amplification (LAMP), was developed by Notomi et al. (2000). Individually published results have been reported that this technology has been successfully applied to the detection of a variety of pathogens. Read More

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http://dx.doi.org/10.1186/s12879-019-3799-4DOI Listing
February 2019

arthritis and pneumonia in calves in Jordan: An emerging disease.

Vet World 2018 Dec 12;11(12):1663-1668. Epub 2018 Dec 12.

Department of Veterinary Clinical Sciences, Faculty of Veterinary Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan.

Aim: Clinical, microbiological, molecular, and pathological assays were undertaken to characterize an outbreak of increasingly reported signs of unresponsive arthritis and pneumonia of infection in young calves in Jordan.

Materials And Methods: Clinical history of the affected bovine herd was investigated for the presence of respiratory and/or joint problems. Two calves with such history were clinically examined and necropsied. Read More

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http://www.veterinaryworld.org/Vol.11/December-2018/3.html
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http://dx.doi.org/10.14202/vetworld.2018.1663-1668DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362338PMC
December 2018
2 Reads

Mycoplasma ovipneumoniae Associated with Polymicrobial Pneumonia in a Free-Ranging Yearling Barren Ground Caribou ( Rangifer tarandus granti) from Alaska, USA.

J Wildl Dis 2019 Feb 15. Epub 2019 Feb 15.

2 US Department of Agriculture, Agricultural Research Services, Animal Disease Research Unit, Washington State University, ADBF 3003, Pullman, Washington 99164, USA.

Mycoplasma ovipneumoniae has been reported in association with respiratory disease only in members of the subfamily Caprinae of the family Bovidae. We identified Mycoplasma ovipneumoniae in a cervid: a free-ranging barren ground caribou ( Rangifer tarandus granti) yearling with polymicrobial bronchopneumonia. Read More

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February 2019

-associated Mucositis: A Recently Described Entity.

Eur J Case Rep Intern Med 2018 28;5(11):000977. Epub 2018 Nov 28.

Internal Medicine Department, Centro Hospitalar do Baixo Vouga, Aveiro, Portugal.

(MP) is a common cause of respiratory infections and can be associated with extrapulmonary complications. MP mucositis has recently been described as a distinct endemic clinical entity called e-induced rash and mucositis (MIRM). The authors present the case of a 46-year-old man with atypical pneumonia associated with exuberant mucositis, conjunctival hyperaemia and positive serological assays for MP IgM. Read More

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http://dx.doi.org/10.12890/2018_000977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346809PMC
November 2018
1 Read

HDAC5 promotes Mycoplasma pneumoniae-induced inflammation in macrophages through NF-κB activation.

Life Sci 2019 Feb 6. Epub 2019 Feb 6.

Department of Paediatrics, First Subsidiary Hospital, University of Science and Technology of He'nan, 471000, China.

Excessive inflammation is fundamental in the pathophysiology of Mycoplasma pneumoniae (MP)-induced respiratory infection in children. Histone deacetylase 5 (HDAC5) is involved in the regulation of inflammation, however, whether it associates with immunity against MP infection is not determined. We report here that HDAC5 expression is decreased in peripheral blood mononuclear cells (PBMCs) from Mycoplasma pneumoniae pneumonia (MPP) children as well as in MP-infected peritoneal and THP-1 macrophages. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.02.004DOI Listing
February 2019
1 Read

A pilot study of the effects of Mycoplasma ovipneumoniae exposure on domestic lamb growth and performance.

PLoS One 2019 7;14(2):e0207420. Epub 2019 Feb 7.

Department of Animal Sciences, Washington State University College of Agricultural, Human, and Natural Resource Sciences, Pullman WA, United States of America.

Mycoplasma ovipneumoniae is a globally distributed pathogen that has been associated with pneumonia in both domestic and wild Caprinae. It is closely related to M. hyopneumoniae, a respiratory pathogen of swine that is associated with decreased growth rates of pigs as well as clinical respiratory disease. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207420PLOS
February 2019
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Comparison of high-dose and low-dose corticosteroid therapy for refractory Mycoplasma pneumoniae pneumonia in children.

J Infect Chemother 2019 Feb 1. Epub 2019 Feb 1.

Department of Pediatrics, Nagoya University Graduate School of Medicine, Japan; Division of Neonatology, Center for Maternal-Neonatal Care, Nagoya University Hospital, Japan.

Background: Mycoplasma pneumoniae pneumonia (MPP) is generally a self-limiting disease, but it may become refractory. It is thought that refractory MPP is linked to the excessive immunologic responses of the host. Consequently, the use of adjunctive systemic corticosteroids may have beneficial effects. Read More

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http://dx.doi.org/10.1016/j.jiac.2019.01.003DOI Listing
February 2019
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The use of multiplex PCR for the detection of atypical pathogens in Egyptian children with CAP: a high rate of in early infancy.

J Egypt Public Health Assoc 2019 18;94(1). Epub 2019 Jan 18.

2Department of Clinical Pathology, Faculty of Medicine, Cairo University, 2 Atteia Abd El Hadi St., El Maadi, Cairo, 11562 Egypt.

Background: Atypical pathogen infections played an important role in community-acquired pneumonia (CAP) in children. Pathogen-specific clinical symptoms are often lacking, and it is difficult to detect atypical pathogens by culture methods. The use of multiplex polymerase chain reaction (PCR) methods enables testing for many pathogens simultaneously in a single analysis. Read More

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http://dx.doi.org/10.1186/s42506-018-0003-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338716PMC
January 2019
7 Reads

Mycoplasma Pneumoniae Pericarditis.

Am J Cardiol 2019 Jan 24. Epub 2019 Jan 24.

Section of Cardiovascular Medicine, Department of Internal Medicine, School of Medicine, Yale University, New Haven, Connecticut. Electronic address:

Mycoplasma pneumoniae is an atypical bacterium that is frequently implicated in respiratory infections, but uncommonly identified as a cause of pericarditis. We report 2 cases of pericarditis attributed to M. pneumoniae that were characterized by prolonged respiratory prodromes, pericardial, and pleural effusions, elevated inflammatory markers, and relapsing clinical courses. Read More

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http://dx.doi.org/10.1016/j.amjcard.2019.01.014DOI Listing
January 2019
1 Read

Loop-mediated isothermal amplification-lateral-flow dipstick (LAMP-LFD) to detect Mycoplasma ovipneumoniae.

World J Microbiol Biotechnol 2019 Jan 30;35(2):31. Epub 2019 Jan 30.

College of Life Sciences, Shihezi University, Xin Jiang, Shihezi, 832000, China.

In order to establish a rapid detection method for Mycoplasma ovipneumoniae, this study used the loop-mediated isothermal amplification (LAMP) technique to carry out nucleic acid amplification and chromatographic visualization via a lateral flow dipstick (LFD) assay. The M. ovipneumoniae elongation factor TU gene (EF-TU) was detected using a set of specific primers designed for the EF-TU gene, and the EF-TU FIP was detected by biotin labeling, which was used in the LAMP amplification reaction. Read More

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http://dx.doi.org/10.1007/s11274-019-2601-5DOI Listing
January 2019
1 Read

Rapid diagnosis of Mycoplasma pneumonia infection by denaturation bubble-mediated strand exchange amplification: comparison with LAMP and real-time PCR.

Sci Rep 2019 Jan 29;9(1):896. Epub 2019 Jan 29.

College of Life Sciences, Qingdao University, Qingdao, 266071, PR China.

M. pneumoniae infection is often ignored due to its similar clinical symptom with respiratory tract infections caused by bacteria or viruses, and thus leading to misdiagnosis and delayed treatment. It is critical to develop a rapid, sensitive and specific diagnosis method. Read More

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http://dx.doi.org/10.1038/s41598-018-36751-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351683PMC
January 2019
6 Reads

Outbreak of Chlamydia pneumoniae Infections and X-ray-Confirmed Pneumonia in Army Trainees at Fort Leonard Wood, Missouri, 2014.

Mil Med 2019 Jan 23. Epub 2019 Jan 23.

US Army Public Health Center, Aberdeen Proving Ground, MD.

Introduction: Chlamydia pneumoniae (Cp) is a bacterium that causes pneumonia and other respiratory diseases. Fever may be present early but absent by time of presentation to clinic. Increases in X-ray-confirmed pneumonia (XCP) and laboratory-confirmed Cp infections were observed in new soldiers in training at Fort Leonard Wood (FLW), Missouri, early in 2014. Read More

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http://dx.doi.org/10.1093/milmed/usy402DOI Listing
January 2019
8 Reads

M. pneumoniae and C. pneumoniae are no relevant pathogens in critically ill patients with hospital-acquired respiratory tract infections.

Infection 2019 Jan 28. Epub 2019 Jan 28.

Institute for Infectious Diseases and Infection Control, Jena University Hospital, Am Klinikum 1, 07747, Jena, Germany.

Purpose: To assess the incidence of Mycoplasma pneumoniae and Chlamydia pneumoniae in the pathogenesis of hospital-acquired respiratory tract infections (RTIs) in critically ill patients.

Methods: This is a retrospective cohort study of all ICU-patients ≥ 18 years with RTI who underwent conventional culture techniques and PCR testing for both M. pneumoniae and C. Read More

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http://dx.doi.org/10.1007/s15010-019-01273-xDOI Listing
January 2019
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Role of Probiotics in Pneumonia in Children: A Short-Term Pilot Project.

Front Microbiol 2018 9;9:3261. Epub 2019 Jan 9.

Department of Gastroenterology, Affiliated Beijing Children's Hospital, Capital Medical University, Beijing, China.

is one of the most common pathogens causing community-acquired pneumonia in children. pneumonia (MPP) can be successfully treated with azithromycin; however, antibiotic-associated diarrhea (AAD) is a common adverse effect. Increasing evidence suggests that some probiotics may prevent the development of AAD. Read More

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http://dx.doi.org/10.3389/fmicb.2018.03261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334620PMC
January 2019
2 Reads

Macrolide prescription in Dutch children: compliance with guidelines.

Eur J Clin Microbiol Infect Dis 2019 Jan 24. Epub 2019 Jan 24.

Department of Clinical Pharmacy, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands.

For reasons of antibiotic resistance and side effects, macrolides should be prescribed with care in the pediatric population. We evaluated the adherence to Dutch guidelines of macrolide prescription in children and estimated the risk of Mycoplasma pneumoniae-associated pneumonia based on Fischer's decision tree. In this retrospective study, we included children aged 0-18 years who were treated with azithromycin or clarithromycin for pulmonary disease in four settings from general practice to hospital ward for (1) the prescriptions not in accordance with the guideline of the Dutch Association of Pediatrics and (2) the risk of M. Read More

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http://dx.doi.org/10.1007/s10096-019-03473-7DOI Listing
January 2019
2 Reads

Positively interacting strains that co-circulate within a network structured population induce cycling epidemics of Mycoplasma pneumoniae.

Sci Rep 2019 Jan 24;9(1):541. Epub 2019 Jan 24.

Centre for Infectious Disease Surveillance and Control, Public Health England, London, UK.

Mycoplasma pneumoniae (MP) is considered a common cause of pneumonia, causing about 15-20% of adult community-acquired pneumonia (CAP) and up to 40% of cases in children. It has often been observed that MP epidemics last approximately 1-2 years and occur every 3-7 years, with the dominant strains alternating between epidemics. However, the underlying mechanism by which these cycles and changes in the dominant strains occur remains unclear. Read More

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http://dx.doi.org/10.1038/s41598-018-36325-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345813PMC
January 2019
2 Reads

[Epidemiological and clinical analysis of community-acquired Mycoplasma pneumonia in children from a Spanish population, 2010-2015].

An Pediatr (Barc) 2019 Jan 21. Epub 2019 Jan 21.

Servicio de Pediatría, Hospital General Universitario, Valencia, España.

Introduction And Objectives: Mycoplasma pneumoniae (MP) is one of the most common etiological agents of community-acquired pneumonia (CAP) in children. We aimed to describe the clinical and epidemiological characteristics, treatment and outcome of children diagnosed with community-acquired MP pneumonia (CAMP) in a tertiary hospital in Valencia, Spain.

Material And Methods: Medical records of children <14 years with CAMP were retrospectively reviewed from January 2010 to December 2015. Read More

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http://dx.doi.org/10.1016/j.anpedi.2018.07.016DOI Listing
January 2019
2 Reads

Changes in antimicrobial susceptibility profiles of over time.

Can J Vet Res 2019 Jan;83(1):34-41

Animal Health Laboratory, Laboratory Services (Cai, McDowall, Parker) and Department of Pathobiology (Kaufman, Caswell), University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1.

is a major cause of pneumonia, arthritis, and mastitis in cattle and can lead to significant economic losses. Antimicrobial resistance is a concern and further limits the already short list of drugs effective against mycoplasmas. The objective of this study was to examine changes in minimum inhibitory concentrations (MICs) of antimicrobials of aminoglycoside, fluoroquinolone, lincosamide, macrolide, pleuromutilin, phenicol, and tetracycline classes for 210 isolates collected from 1978 to 2009. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318825PMC
January 2019

Identfication of viral and bacterial etiologic agents of the pertussis-like syndrome in children under 5 years old hospitalized.

BMC Infect Dis 2019 Jan 21;19(1):75. Epub 2019 Jan 21.

School of Medicine. Research and Innovation Centre of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima, Peru.

Background: Acute respiratory infections (ARIs) represent an important cause of morbidity and mortality in children, remaining a major public health concern, especially affecting children under 5 years old from low-income countries. Unfortunately, information regarding their epidemiology is still limited in Peru.

Methods: A secondary data analysis was performed from a previous cross-sectional study conducted in children with a probable diagnosis of Pertussis from January 2010 to July 2012. Read More

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http://dx.doi.org/10.1186/s12879-019-3671-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341522PMC
January 2019
1 Read

A concise review of vaccines against Mycoplasma hyopneumoniae.

Res Vet Sci 2019 Jan 9;123:144-152. Epub 2019 Jan 9.

Department of Biochemistry and Molecular Biology, College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou 310018, China. Electronic address:

Mycoplasma hyopneumoniae (Mhp) is the pathogen of Mycoplasmal pneumonia of swine (MPS), a chronic respiratory infectious discease which causes enormous losses to the swine industry worldwide. At present, vaccination is the most effective mean to prevent and reduce economic losses caused by this pathogen. Currently, MPS vaccines mainly include inactivated vaccines and attenuated live vaccines. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00345288183145
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http://dx.doi.org/10.1016/j.rvsc.2019.01.007DOI Listing
January 2019
4 Reads

Genetic diversity of Mycoplasma hyopneumoniae in Mendoza province.

Rev Argent Microbiol 2019 Jan 13. Epub 2019 Jan 13.

Departamento de Patología Animal, Facultad de Agronomía y Veterinaria, Universidad Nacional de Río Cuarto, Córdoba, Argentina. Electronic address:

In Argentina, enzootic pneumonia (EP) is highly prevalent and different genetic types of Mycoplasma hyopneumoniae have been identified. However, there is a lack of information about prevalence and other epidemiological aspects of EP in Mendoza province. A multiple Locus variable-number tandem repeat analysis (MLVA) targeting P97 R1, P97 R1A and P146 R3 loci was used to assess the genetic diversity of M. Read More

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http://dx.doi.org/10.1016/j.ram.2018.07.004DOI Listing
January 2019
1 Read

Acute Bronchitis Caused by Bordetella Pertussis Possibly Co-Infected with Mycoplasma Pneumoniae.

Am J Case Rep 2019 Jan 15;20:60-64. Epub 2019 Jan 15.

Department of Internal Medicine, Iwakiri Hospital, Miyagino, Sendai, Miyagi, Japan.

BACKGROUND Mycoplasma pneumoniae and Bordetella pertussis are among the causative pathogens of human acute bronchitis, which usually has mild symptoms. However, if there is a co-infection, the symptoms often can be prolonged and occasionally can lead to severe respiratory complications. CASE REPORT A 49-year-old Japanese female, who had not been vaccinated for B. Read More

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https://www.amjcaserep.com/abstract/index/idArt/913430
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http://dx.doi.org/10.12659/AJCR.913430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340264PMC
January 2019
5 Reads

Comparison of vaccination protocols against Mycoplasma hyopneumoniae during the gilt acclimation period.

Vet Microbiol 2019 Feb 12;229:7-13. Epub 2018 Dec 12.

IRTA, Centre de Recerca en Sanitat Animal (CRESA, IRTA-UAB), Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain. Electronic address:

This study evaluated different gilt vaccination protocols against Mycoplasma (M.) hyopneumoniae at acclimation and their effect on the genetic diversity. A total of 180 M. Read More

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http://dx.doi.org/10.1016/j.vetmic.2018.12.005DOI Listing
February 2019
2 Reads

Increased risk of rheumatoid arthritis among patients with Mycoplasma pneumonia: A nationwide population-based cohort study in Taiwan.

PLoS One 2019 14;14(1):e0210750. Epub 2019 Jan 14.

Division of Allergy, Immunology and Rheumatology, Chung Shan Medical University Hospital, Taichung, Taiwan.

Objective: An association between Mycoplasma pneumonia (MP) and rheumatoid arthritis (RA) had been reported in animal studies for decades. However, clinical evidence for this association is lacking. Therefore, this study aimed to provide epidemiologic evidence to clarify the relationship between MP and development of RA. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210750PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331094PMC
January 2019
9 Reads

Clinical Characteristics and Antibiotic Resistance of Mycoplasma Pneumoniae Pneumonia in Hospitalized Chinese Children.

Comb Chem High Throughput Screen 2019 Jan 10. Epub 2019 Jan 10.

Department of Respiration, The First Hospital of Huzhou, First Affiliated Hospital of Huzhou University, No. 158 Guangchanghou Road, Huzhou, Zhejiang, 313000. China.

Aim To analyze the clinical characteristics and antibiotic resistance of Mycoplasma pneumoniae pneumonia (MP) in Chinese patients, providing valuable information for the management of patients with MP. Methods A total of 120 children who were hospitalized in The First Hospital of Huzhou between January and December 2016 for respiratory tract infection due to M. pneumoniae were enrolled in this study. Read More

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http://dx.doi.org/10.2174/1386207322666190111112946DOI Listing
January 2019
4 Reads

First detection and characterization of macrolide-resistant Mycoplasma pneumoniae strains in Cuba.

Int J Infect Dis 2019 Jan 10;80:115-117. Epub 2019 Jan 10.

TU Dresden, Institute of Medical Microbiology and Hygiene, Dresden, Germany.

Objectives: Mycoplasma pneumoniae is a common cause of community-acquired pneumonia in humans. Treatment of infections can be complicated by the occurrence of macrolide resistant strains. The study was conducted to evaluate the presence of resistant strains in Cuba and to determine the corresponding genotypes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S12019712193000
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http://dx.doi.org/10.1016/j.ijid.2018.12.018DOI Listing
January 2019
8 Reads

Effects of pre-farrowing sow vaccination against on offspring colonisation and lung lesions.

Vet Rec 2019 Feb 10;184(7):222. Epub 2019 Jan 10.

Unit Porcine Health Management, Department of Reproduction, Obstetrics & Herd Health, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.

This study investigated colonisation and lung lesions at slaughter in pigs from vaccinated (V) and non-vaccinated (NV) sows, in two herds (A and B). In each herd, two sow batches were V against with a commercial bacterin at six and three weeks before farrowing and two sow batches remained NV. From each sow batch, laryngeal swabs were collected from the litters of five primiparous sows at weaning and seven days post-weaning. Read More

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http://dx.doi.org/10.1136/vr.104972DOI Listing
February 2019
1 Read

Clinical features of coinfection and need for its testing in influenza pneumonia patients.

J Thorac Dis 2018 Nov;10(11):6118-6127

Department of Emergency Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.

Background: To investigate the clinical features of coinfection due to (), a common copathogen in influenza, in influenza pneumonia patients.

Methods: We reviewed 4,465 patients with influenza who visited a tertiary care hospital emergency department in Seoul (Korea) from 2010 through 2016, and underwent immunoglobulin M (IgM) serology or polymerase chain reaction (PCR) for . Influenza pneumonia was defined as laboratory-confirmed influenza plus radiographic pneumonia. Read More

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http://jtd.amegroups.com/article/view/24984/19090
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http://dx.doi.org/10.21037/jtd.2018.10.33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297417PMC
November 2018
5 Reads

Distribution of the atypical pathogens of community-acquired pneumonia to disease severity.

J Thorac Dis 2018 Nov;10(11):5991-6001

Institute for Immunization and Prevention, Beijing Center for Disease Prevention and Control, Beijing Research Center for Preventive Medicine, Beijing 100013, China.

Background: To investigate the epidemiological characteristics of 11 atypical pathogens of community-acquired pneumonia (CAP) among Chinese, and to determine whether or not there is an association between these pathogens and the severity of illness.

Methods: We conducted a surveillance study for CAP in 30 hospitals of Beijing. Epidemiological data and clinical specimens were systematically collected from enrolled CAP patients. Read More

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http://jtd.amegroups.com/article/view/25110/19077
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http://dx.doi.org/10.21037/jtd.2018.10.50DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297405PMC
November 2018
8 Reads

A Case of Influenza B and Coinfection in an Adult.

Case Rep Infect Dis 2018 25;2018:3529358. Epub 2018 Nov 25.

Department of Respiratory Medicine, Tokyo Dental College Ichikawa General Hospital, 5-11-13, Sugano, Ichikawa, Chiba 272-0824, Japan.

A 19-year-old woman was referred to our hospital because of a persistent fever and cough that lasted for over a week. Influenza B virus infection was diagnosed using the rapid test kit. Initially, the patient was diagnosed with influenza B infection associated with lobar pneumonia and treated with an anti-influenza virus drug and sulbactam/ampicillin. Read More

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http://dx.doi.org/10.1155/2018/3529358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286767PMC
November 2018
2 Reads

Necrotizing pneumonia due to Mycoplasma in children: an uncommon presentation of a common disease.

Adv Respir Med 2018 Dec 30. Epub 2018 Dec 30.

DEPARTMENT OF PEDIATRICS. COMPLEJO HOSPITAL DE NAVARRA, C/ IRUNLARREA 3, 31008 PAMPLONA, Spain; INSTITUTO DE INVESTIGACION SANITARIA DE NAVARRA IdisNa, c Irunlarrea, 31008 pamplona, Spain.

Mycoplasma pneumoniae is a common respiratory pathogen, especially in children, responsible for community-acquired pneumonia. Although, in most cases, infections caused by this bacterium follow a benign self-limited clinical course, cases of severe respiratory infections have been reported. We present two pediatric cases of necrotizing pneumonia due to Mycoplasma pneumoniae. Read More

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http://dx.doi.org/10.5603/ARM.a2018.0049DOI Listing
December 2018
2 Reads

Antibiotic susceptibility profiles of Mycoplasma hyorhinis strains isolated from swine in Hungary.

Vet Microbiol 2019 Jan 28;228:196-201. Epub 2018 Nov 28.

Institute for Veterinary Medical Research, Centre for Agricultural Research, Hungarian Academy of Sciences, Hungária körút 21, Budapest, 1143, Hungary; Department of Microbiology and Infectious Diseases, University of Veterinary Medicine, Hungária körút 23-25, Budapest, 1143, Hungary. Electronic address:

Mycoplasma hyorhinis is a common pathogen of swine causing mainly polyserositis and arthritis, but it has also been implicated as a cause of pneumonia. The economic losses due to M. hyorhinis infection could be reduced by antibiotic treatment. Read More

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http://dx.doi.org/10.1016/j.vetmic.2018.11.027DOI Listing
January 2019
2 Reads

Impact of bacterial and viral coinfection in community-acquired pneumonia in adults.

Diagn Microbiol Infect Dis 2018 Nov 24. Epub 2018 Nov 24.

Department of Laboratory Medicine, Chung-Ang University College of Medicine, Seoul, Republic of Korea. Electronic address:

Bacterial and viral coinfected community-acquired pneumonia (CAP) is poorly characterized in adults. The aim of this study was to investigate the influence of bacterial and viral coinfection in patients with CAP. A total of 235 adults who requested molecular tests of pneumonia and were diagnosed with CAP were enrolled in this study. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07328893183066
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http://dx.doi.org/10.1016/j.diagmicrobio.2018.11.014DOI Listing
November 2018
16 Reads

The HapE alters the cytokine profile and growth of human bronchial epithelial cells.

Biosci Rep 2019 Jan 18;39(1). Epub 2019 Jan 18.

Department of Bacteriology, Capital Institute of Pediatrics, Beijing 100020, China

is one of the most common pathogenic causes of community-acquired pneumonia. Hydrogen sulfide, alanine, and pyruvate producing enzyme (HapE) is a recently discovered virulence factor that can produce HS to promote erythrocyte lysis. However, other cytotoxic effects of HapE have not been explored. Read More

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http://bioscirep.org/lookup/doi/10.1042/BSR20182201
Publisher Site
http://dx.doi.org/10.1042/BSR20182201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340952PMC
January 2019
12 Reads

Independent predictors for longer radiographic resolution in patients with refractory pneumonia: a prospective cohort study.

BMJ Open 2018 Dec 18;8(12):e023719. Epub 2018 Dec 18.

Department of Respiratory Medicine, Children's Hospital of Soochow University, Suzhou, Jiangsu, China.

Objectives: To examine prospectively the radiographic clearance of refractory pneumonia (RMPP) in immunocompetent children, and to identify independent predictors of time to complete radiographic resolution in patients with RMPP.

Design: A prospective cohort study.

Setting: Children's Hospital of Soochow University, China. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303577PMC
December 2018
3 Reads

Atypical pathogens in hospitalized patients with community-acquired pneumonia: a worldwide perspective.

BMC Infect Dis 2018 Dec 18;18(1):677. Epub 2018 Dec 18.

Division of Pulmonary Diseases and Critical Care Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.

Background: Empirical antibiotic coverage for atypical pathogens in community-acquired pneumonia (CAP) has long been debated, mainly because of a lack of epidemiological data. We aimed to assess both testing for atypical pathogens and their prevalence in hospitalized patients with CAP worldwide, especially in relation with disease severity.

Methods: A secondary analysis of the GLIMP database, an international, multicentre, point-prevalence study of adult patients admitted for CAP in 222 hospitals across 6 continents in 2015, was performed. Read More

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http://dx.doi.org/10.1186/s12879-018-3565-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299604PMC
December 2018
1 Read

Polydatin suppresses the development of lung inflammation and fibrosis by inhibiting activation of the NACHT domain-, leucine-rich repeat-, and pyd-containing protein 3 inflammasome and the nuclear factor-κB pathway after Mycoplasma pneumoniae infection.

J Cell Biochem 2018 Dec 12. Epub 2018 Dec 12.

Centre for Reproductive Medicine and Department of Laboratory Medicine, First Affiliated Hospital, Second Military Medical University, Shanghai, China.

Mycoplasma pneumoniae (MP) can infect both the upper and lower respiratory tracts. Polydatin (PD), a traditional Chinese medicine, is known to have anti-inflammation and antifibrosis properties. However, the protective effects of PD against MP pneumonia (MPP) remain unclear. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcb.28297
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http://dx.doi.org/10.1002/jcb.28297DOI Listing
December 2018
3 Reads
3.263 Impact Factor

Assessment of levels of D-dimer and interferon-γ in pediatric patients with pneumonia and its clinical implication.

Exp Ther Med 2018 Dec 17;16(6):5025-5030. Epub 2018 Oct 17.

The Second Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang 161000, P.R. China.

Levels of D-dimer and interferon-γ (INF-γ) in pediatric patients with pneumonia (MPP) were assessed to explore its clinical implication in evaluating the disease severity and patients' prognosis. Enrolled in this study as subjects were 185 pediatric patients with MPP who were admitted to the Department of Pediatrics of the Second Affiliated Hospital of Qiqihar Medical University and the First Hospital of Qiqihar City from January 2017 to October 2017 and 115 healthy children who underwent physical examination during the same time period. Patients were divided into two groups according to the severity of their pneumonia: Severe pneumonia group with 95 patients and mild pneumonia group with 90 patients. Read More

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http://dx.doi.org/10.3892/etm.2018.6873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256836PMC
December 2018

Implementation of Point-of-Care Molecular Diagnostics for Mycoplasma pneumoniae Ensures the Correct Antimicrobial Prescription for Pediatric Pneumonia Patients.

Tohoku J Exp Med 2018 12;246(4):225-231

Department of Pediatrics, Tsukuba Medical Center Hospital.

Mycoplasma pneumoniae is a leading causative pathogen of pneumonia among pediatric patients, and its accurate diagnosis may aid in the selection of appropriate antimicrobial agents. We established a rapid reporting system of a polymerase chain reaction (PCR) examination for M. pneumoniae that enables physicians to obtain test results approximately 90 minutes after ordering the test. Read More

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http://dx.doi.org/10.1620/tjem.246.225DOI Listing
December 2018

[Epidemiological investigation and analysis of an outbreak of mycoplasma pneumoniae pneumonia in adult].

Zhonghua Yi Xue Za Zhi 2018 Dec;98(46):3784-3788

Graduate College of Fujian Medical University, Fuzhou 350108, China.

To conduct an epidemiological investigation and analysis of an outbreak of mycoplasma pneumonia in adults. The first case was a 23-year-old male came from the Third Military Medical University, who served as an intern in the Fuzhou General Hospital of PLA and presented on July 16, 2015 with a history of low-grade fever, dizziness, fatigue and chest tightness. Chest CT revealed pulmonary nodules shadow. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2018.46.012DOI Listing
December 2018

Mycoplasma hyopneumoniae resides intracellularly within porcine epithelial cells.

Sci Rep 2018 Dec 6;8(1):17697. Epub 2018 Dec 6.

The ithree institute, University of Technology Sydney, Ultimo, NSW, 2007, Australia.

Enzootic pneumonia incurs major economic losses to pork production globally. The primary pathogen and causative agent, Mycoplasma hyopneumoniae, colonises ciliated epithelium and disrupts mucociliary function predisposing the upper respiratory tract to secondary pathogens. Alleviation of disease is reliant on antibiotics, vaccination, and sound animal husbandry, but none are effective at eliminating M. Read More

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http://dx.doi.org/10.1038/s41598-018-36054-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283846PMC
December 2018
2 Reads

[A multicenter clinical study on 1 138 cases of invasive pneumococcal disease in children from 2012 to 2017].

Zhonghua Er Ke Za Zhi 2018 Dec;56(12):915-922

Zunyi Medical University, Zunyi 563003, China.

To explore the clinical features, the serotype distribution and drug resistance of the isolates in patient with invasive pneumococcal disease (IPD). By retrieving the laboratory information system in 18 children's hospitals from 2012 to 2017, the children with IPD were enrolled. (Spn) must be isolated from the sterile sites (blood, cerebrospinal fluid, hydrothorax and joint effusion etc. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1310.2018.12.006DOI Listing
December 2018
6 Reads

Prevalence and Clinical Features of Community-Acquired Pneumonia Caused by Macrolide-Resistant Mycoplasma pneumoniae Isolated from Adults in Jeju Island.

Microb Drug Resist 2018 Nov 28. Epub 2018 Nov 28.

2 Department of Internal Medicine, Jeju National University Hospital, Jeju National University School of Medicine , Jeju, Republic of Korea.

Aims: Although the cases of macrolide-resistant Mycoplasma pneumoniae (MRMP) have been increasing substantially among children, there are very few studies that have focused on MRMP in adults. This study aimed to investigate the prevalence and clinical features of community-acquired pneumonia (CAP) caused by MRMP from adults in Jeju Island, Korea.

Methods: We retrospectively recruited adult patients with CAP in whom M. Read More

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http://dx.doi.org/10.1089/mdr.2018.0295DOI Listing
November 2018
1 Read

Improved Detection of Culprit Pathogens by Bacterial DNA Sequencing Affects Antibiotic Management Decisions in Severe Pneumonia.

Am J Case Rep 2018 Nov 26;19:1405-1409. Epub 2018 Nov 26.

Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.

BACKGROUND Severe pneumonia requiring admission to an intensive care unit carries high morbidity and mortality. Evidence-based management includes early administration of empiric antibiotics against plausible bacterial pathogens while awaiting results of microbiologic cultures. However, in over 60% of pneumonia cases, no causative pathogen is identified with conventional diagnostic techniques. Read More

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https://www.amjcaserep.com/abstract/index/idArt/912055
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http://dx.doi.org/10.12659/AJCR.912055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280716PMC
November 2018
8 Reads

A versatile loop-mediated isothermal amplification microchip platform for Streptococcus pneumoniae and Mycoplasma pneumoniae testing at the point of care.

Biosens Bioelectron 2019 Feb 12;126:373-380. Epub 2018 Nov 12.

Department of Laboratory Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China. Electronic address:

Community-acquired pneumonia (CAP) is the leading cause of mortality in children under five years of age, globally. Given that Streptococcus pneumoniae (S. pneumoniae) and Mycoplasma pneumoniae (M. Read More

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http://dx.doi.org/10.1016/j.bios.2018.11.011DOI Listing
February 2019
4 Reads
6.409 Impact Factor