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Comp Immunol Microbiol Infect Dis 2022 Jun 8;87:101835. Epub 2022 Jun 8.

Vaccine and Infectious Disease Organization (VIDO), University of Saskatchewan, 120 Veterinary Rd, Saskatoon, SK S7N 5E3, Canada.

Mycoplasma bovis (M. bovis) in cattle causes pneumonia, arthritis, otitis media, and mastitis. In addition, multiple outbreaks have been recorded in North American bison. Read More

Front Microbiol 2022 6;13:888433. Epub 2022 Jun 6.

Department of Animal Science, University of Connecticut, Storrs, CT, United States.

is an insidious, wall-less primary bacterial pathogen that causes bovine pneumonia, mid-ear infection, mastitis, and arthritis. The economic losses caused by due to culling, diminished milk production, and feed conversion are underestimated because of poor diagnosis/recognition. Treatment with common antibiotics targeting the cell wall is ineffective. Read More

Biotechnol Appl Biochem 2022 Jun 20. Epub 2022 Jun 20.

Department of Inspection, First Hospital of Shanxi Medical University, Taiyuan, Shanxi Province, 030000, China.

Mycoplasma pneumoniae (M. pneumoniae) is a highly infectious bacterium and the major cause of pneumonia, especially in school children. Mycoplasma pneumoniae affects the respiratory tract, and 25% of patients experience health-related problems. Read More

Microb Pathog 2022 Jun 18;169:105647. Epub 2022 Jun 18.

Beijing Tropical Medicine Research Institute, Beijing Friendship Hospital, Capital Medical University, No. 95 Yong-an Road, Xicheng District, Beijing, 100050, China. Electronic address:

Mycoplasma pneumoniae (MP) is an important respiratory pathogen of human. The infection of MP can cause direct damage and immune damage in lung, resulting in Mycoplasma pneumoniae pneumonia (MPP). In this study, we aim to investigate the pathogenesis of MPP by detecting the proliferation of MP under conditions of cell damages and neutrophils in vitro. Read More

Cureus 2022 May 16;14(5):e25052. Epub 2022 May 16.

Internal Medicine, Northwest General Hospital, Peshawar, PAK.

is a respiratory pathogen responsible for community-acquired atypical pneumonia. Apart from respiratory manifestations, other system involvement has also been reported. We present a case of interstitial pneumonia and a concurrent episode of acute pancreatitis in a young female who presented with fever, cough, vomiting, and epigastric pain. Read More

J Infect Chemother 2022 Jun 16. Epub 2022 Jun 16.

First Department of Internal Medicine, Division of Respiratory Medicine, Infectious Disease and Allergology, Kansai Medical University, Japan.

Introduction: The Japanese Respiratory Society (JRS) scoring system is a useful tool for the rapid presumptive diagnosis of atypical pneumonia in non-elderly (aged <60 years) patients. As SARS-CoV-2 vaccination progresses, COVID-19 in elderly people has markedly reduced. We investigated changes in diagnostic usefulness of the JRS scoring system in COVID-19 pneumonia between the Delta variant group (vaccination period) and non-Delta variant group (before the vaccination period). Read More

J Dermatol 2022 Jun 17. Epub 2022 Jun 17.

Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Taipei,Linkuo and Keelung, Taiwan.

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening cutaneous conditions. However, studies of pediatric SJS/TEN are limited. To investigate the causes, clinical course, outcomes and complications of SJS and TEN in children. Read More

J Wildl Dis 2022 Jun 15. Epub 2022 Jun 15.

Department of Veterinary Sciences, University of Wyoming, 1174 Snowy Range Road, Laramie, Wyoming 82070, USA.

Mycoplasma bovis is an economically important bacterial pathogen of cattle (Bos taurus) and bison (Bison bison) that most commonly causes pneumonia, polyarthritis, and mastitis. It is prevalent in cattle and ranched bison; however, infections in other species are rare. In early 2019, we identified M. Read More

Int Arch Allergy Immunol 2022 Jun 14:1-16. Epub 2022 Jun 14.

Department of Respiratory Medicine, Hunan Children's Hospital, Changsha, China.

Background: Infantile pneumonia is an acute inflammatory lesion of the lung caused by mycoplasma pneumonia. Indeed, Twist2 signaling pathway controls inflammatory reaction, oxidative stress, and other biological reaction. However, the regulation of Twist2 on the inflammation in infantile pneumonia remains unclear. Read More

mSystems 2022 Jun 14:e0028222. Epub 2022 Jun 14.

Institute of Food Safety and Nutrition, Key Lab of Food Quality and Safety of Jiangsu Province-State Key Laboratory Breeding Base, Jiangsu Academy of Agricultural Sciencesgrid.454840.9, Nanjing, China.

Lung inflammation induced by Mycoplasma hyorhinis infection accounts for significant economic losses in the swine industry. Increasing evidence suggests that there is cross talk between the lungs and the gut, but little is known about the effect of the lung inflammation caused by infection on gut microbiota and intestinal barrier function. Here, we investigated changes in the fecal microbiotas of pigs with infection and the microbial regulatory role of such infection in intestinal barrier function. Read More

Access Microbiol 2022 21;4(3):000332. Epub 2022 Mar 21.

Pediatrics Department, King Hamad University Hospital, Busaiteen, Bahrain.

Respiratory tract infections are a leading cause of hospital visits in the paediatric population and carry significant associated morbidity and mortality in this population. The introduction of respiratory panel testing has been said to guide clinicians in the overall management of patients. We conducted a retrospective study examining all respiratory panels carried out in our hospital during 2019 on paediatric patients. Read More

Front Surg 2022 25;9:897550. Epub 2022 May 25.

Department of Pediatrics, The First People's Hospital of Linping District, Hangzhou, China.

Objective: To investigate the clinical characteristics of children with severe Mycoplasma pneumoniae pneumonia (SMPP) and the correlation with pediatric critical illness score (PICS), and to explore the effect of combined treatment with antibiotics and glucocorticoids.

Methods: The medical records of 120 children with SMPP admitted to our hospital from January 2020 to June 2021 were retrospectively analyzed. Children with a PICS score greater than 80 within 24 h of admission were included in the non-critical group, those with a score of 71-80 were included in the critical group, and those with a score of ≤70 were included in the extremely critical group. Read More

Vet Res 2022 Jun 13;53(1):41. Epub 2022 Jun 13.

Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna, Via Bianchi, 9, 25124, Brescia, Italy.

Little is known about how co-infections and genotype dynamics affect Mycoplasma hyopneumoniae infection in fattening pigs. This study was aimed at assessing the role of co-infections in M. hyopneumoniae outbreaks, their influence on the presence of M. Read More

Transl Pediatr 2022 May;11(5):738-747

Department of Pediatrics, the Sixth People's Hospital Affiliated to Shanghai Jiaotong University, Shanghai, China.

Background: In infants and young children, the clinical decision to apply glucocorticoids to severe pneumonia (SMPP) is more an empirical choice with reference to clinical symptoms, but the effect is not satisfying. We aimed to explore and identify early predictive indicators of ideal response to glucocorticoids treatment in SMPP in infants and young children.

Methods: We retrospectively reviewed the data of 59 patients, which met the age range and diagnostic criteria, admitted to Department of Pediatrics, the Sixth People's Hospital Affiliated to Shanghai Jiaotong University, from January to December 2017. Read More

Porcine Health Manag 2022 Jun 9;8(1):26. Epub 2022 Jun 9.

Department of Internal Medicine, Reproduction and Population Medicine, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.

Background: Dam-to-piglet transmission plays an important role in the epidemiology of enzootic pneumonia on farms. Although Mycoplasma hyopneumoniae (M. hyopneumoniae) infections in breeding animals are often subclinical, their control could have a positive effect on M. Read More

J Antimicrob Chemother 2022 Jun 9. Epub 2022 Jun 9.

Department of pharmacy, Karamay central hospital of Xinjiang, Karamay, Xinjiang, China.

Objectives: To determine the prevalence of resistance to macrolides in Mycoplasma pneumoniae worldwide.

Methods: Prior to 12 December 2020, PubMed, Web of Science, Scopus and Embase databases were searched for epidemiological studies of M. pneumoniae resistance. Read More

J Vet Med Sci 2022 Jun 8. Epub 2022 Jun 8.

Department of Veterinary Medicine, College of Veterinary Medicine, National Pingtung University of Science and Technology.

This study aimed to investigate the prevalence at both farm-level and calf-level and to identify the risk factors of respiratory bacterial pathogens in dairy calves in Taiwan. The status of bovine respiratory disease (BRD) was evaluated by using the Wisconsin scoring system from a total of 400 pre-weaned calves from 32 different farms in Taiwan, then the nasopharyngeal swabs were collected. The prevalence of respiratory pathogens was 84. Read More

World J Microbiol Biotechnol 2022 Jun 7;38(7):128. Epub 2022 Jun 7.

Animal Health Unit, Department of Health and Environmental Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Japan.

The study aimed to develop a pair of polymerase chain reaction primers for detecting ruminant mycoplasma pathogens. We designed a set of primers based on the most similar sequences within 16 S rRNA regions of seven Mycoplasma spp. These primers have high sensitivity for detecting Mycoplasma dispar, M. Read More

Indian J Pediatr 2022 Jun 6. Epub 2022 Jun 6.

Department of Pediatrics, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, 61469, Republic of Korea.

Objective: To elucidate the clinical usefulness of lactate dehydrogenase (LDH) levels in children with Mycoplasma pneumoniae (MP) pneumonia and identify cut-off levels in various clinical conditions.

Methods: The study was retrospectively performed in 145 children who were hospitalized with MP pneumonia. Laboratory findings, including LDH levels at admission and clinical features were retrospectively reviewed from patients' electronic medical records. Read More

Cureus 2022 Apr 28;14(4):e24563. Epub 2022 Apr 28.

Internal Medicine, Oak Hill, Tampa, USA.

Background and objective The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus that causes coronavirus disease 2019 (COVID-19) infection, with symptoms ranging from mild upper respiratory illness to multisystem organ failure, and even death. Since its discovery in December 2019, the SARS-CoV-2 virus has led to a global pandemic, rapidly spreading to countries around the world, with millions of reported deaths to date. As researchers around the world continue to analyze and interpret the data gathered regarding the novel virus, it is evident that its co-infection with various bacterial pathogens is associated with a worse overall prognosis. Read More

Am J Case Rep 2022 Jun 3;23:e936264. Epub 2022 Jun 3.

Department of Internal Medicine, Detroit Medical Center Sinai Grace Hospital, Detroit, USA.

BACKGROUND Legionella infection is a common cause of atypical pneumonia, known as Legionnaires' disease when infection extends to extrapulmonary involvement, which often leads to hospitalization. The triad of Legionella pneumonia, rhabdomyolysis, and renal failure displays a rare yet fatal complication without prompt management. CASE REPORT Our patient was a 62-year-old man with no significant medical history who developed Legionnaires' disease with severely elevated creatinine phosphokinase (CPK) of 9614 mcg/L, consistent with rhabdomyolysis. Read More

BMC Vet Res 2022 Jun 2;18(1):211. Epub 2022 Jun 2.

Department of Large Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, SK, S7N 5B4, Canada.

Background: Bovine respiratory disease (BRD) is an important cause of morbidity and mortality and is responsible for most of the injectable antimicrobial use in the feedlot industry. Traditional bacterial culture can be used to diagnose BRD by confirming the presence of causative pathogens and to support antimicrobial selection. However, given that bacterial culture takes up to a week and early intervention is critical for treatment success, culture has limited utility for informing rapid therapeutic decision-making. Read More

J Microbiol Methods 2022 Jul 30;198:106504. Epub 2022 May 30.

NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, No. 155, Changbai Street, Changping District, Beijing 102206, China. Electronic address:

Background: Pneumonia caused by Mycoplasma pneumoniae is common in the elderly and children, and pneumonia caused by Chlamydia trachomatis is prevalent in newborns. This study aimed to establish a rapid, sensitive, and simple method for the direct detection of M. pneumoniae and C. Read More

BMC Pulm Med 2022 May 30;22(1):212. Epub 2022 May 30.

Department of Pediatrics, Chonnam National University Hospital, Chonnam National University Medical School, Jebong-ro, Dong-gu, Gwangju, 61469, Republic of Korea.

Background: The prevalence of refractory Mycoplasma pneumoniae (MP) pneumonia has been increasing. However, few studies have investigated the impact of respiratory virus coinfection in patients with MP pneumonia, and their results have been inconclusive. This study aimed to investigate the impact of respiratory virus coinfection in children hospitalized with MP pneumonia. Read More

Pak J Med Sci 2022 Mar-Apr;38(4Part-II):826-832

Jinyu An, Department of Orthopedics, Changzhou Cancer Hospital Affiliated to Soochow University, Changzhou, 213000, Jiangsu, China.

Objectives: To investigate the effects of Reduning combined with gamma globulin on symptom improvement and serum levels of interleukin-6 (IL-6), 25-hydroxyvitamin D[25-(OH)D] and lactate dehydrogenase (LDH) in children with severe mycoplasma pneumonia (MP).

Methods: A total of 123 children with severe MP admitted to the Changzhou Cancer Hospital affiliated to Soochow University from May 2018 to April 2020 were selected as subjects and randomly divided into three groups: control Group-A, control Group-B and the observation group, with 41 cases in each group. Control Group-A was given with Reduning, control Group-B was treated with gamma globulin, while the observation group was treated with Reduning injection combined with gamma globulin. Read More

Pak J Med Sci 2022 Mar-Apr;38(4Part-II):922-927

Xiaohua Gou Pulmonary and Critical Care Medicine 2 Department, Baoding First Central Hospital, Baoding071000, Hebei, China.

Objectives: To investigate the clinical efficacy of budesonide suspension through bronchofiberscopic lavage in the treatment of refractory mycoplasma pneumoniae pneumonia.(RMPP).

Methods: A total of 108 children with refractory mycoplasma pneumoniae pneumonia from June 2018 to October 2020 were randomly divided into two groups: the study group and the control group, with 54 cases in each group. Read More

J Clin Med 2022 May 17;11(10). Epub 2022 May 17.

Department of Pulmonology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310052, China.

Refractory pneumonia (RMPP) is a severe state of infection that has attracted increasing universal attention in recent years. The pathogenesis of RMPP remains unknown, but the excessive host immune responses as well as macrolide resistance of M. pneumoniae might play important roles in the development of RMPP. Read More

Rev Argent Microbiol 2022 May 20. Epub 2022 May 20.

Facultad de Agronomía y Veterinaria, Universidad Nacional de Río Cuarto, Ruta N° 36 km 601, X5804BYA Córdoba, Argentina.

Bovine respiratory disease (BRD) is one of the most frequent clinical concerns in weaned calves after their arrival at the feedlot. This work reports the first local isolation of Mycoplasma bovis from feedlot calves with pneumonia and polyarthritis in Argentina. Twenty four out of 545 calves showed progressive, subacute to chronic respiratory distress, coughing, and fever. Read More

Contrast Media Mol Imaging 2022 4;2022:6460865. Epub 2022 May 4.

Department of Pharmacy, Yiwu Central Hospital, Yiwu 322000, Zhejiang, China.

The aim of this study was to investigate the value of high-resolution computed tomography (CT) images and mycoplasma (MP) ribonucleic acid (RNA) load detection in the early diagnosis of refractory mycoplasma (RMP) and provide more methods for the diagnosis and treatment of RMP. Seventy children with MP were divided into the RMP group (H1 group, 31 cases) and the MP group (H2 group, 39 cases) according to pathological findings, and all of them underwent CT scanning. MP-RNA load and genotype distribution were analyzed in both groups, and the diagnostic efficacy of CT combined with MP-RNA load for RMP was calculated. Read More

J Formos Med Assoc 2022 May 19. Epub 2022 May 19.

Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:

Background: Mycoplasma pneumoniae is a pathogen that causes respiratory diseases in children. Infections caused by M. pneumoniae are usually self-limited but occasionally can be severe. Read More