144,163 results match your criteria Pneumonia Immunocompromised


Point-of-care lung ultrasound for the detection of pulmonary manifestations of malaria and sepsis: An observational study.

PLoS One 2018 12;13(12):e0204832. Epub 2018 Dec 12.

Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

Introduction: Patients with severe malaria or sepsis are at risk of developing life-threatening acute respiratory distress syndrome (ARDS). The objective of this study was to evaluate point-of-care lung ultrasound as a novel tool to determine the prevalence and early signs of ARDS in a resource-limited setting among patients with severe malaria or sepsis.

Materials And Methods: Serial point-of-care lung ultrasound studies were performed on four consecutive days in a planned sub study of an observational cohort of patients with malaria or sepsis in Bangladesh. Read More

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December 2018

Association of Noninfectious Pneumonia With Ustekinumab Use.

JAMA Dermatol 2018 Dec 12. Epub 2018 Dec 12.

Office of Surveillance and Epidemiology, Division of Pharmacovigilance, FDA Center for Drug Evaluation and Research, Silver Spring, Maryland.

Importance: The US Food and Drug Administration (FDA) conducts ongoing public health safety surveillance for drug and therapeutic biologic products. Identifying cases of acute and subacute noninfectious pneumonia supports the public health mission of the FDA.

Objective: To identify and analyze postmarketing cases of noninfectious pneumonia associated with ustekinumab use. Read More

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December 2018

Cohort study of risk factors for 30-day readmission after abdominal aortic aneurysm repair.

Vasa 2018 Dec 12:1-11. Epub 2018 Dec 12.

1 Division of Vascular Surgery, University of Missouri Hospitals & Clinics, Columbia, MO, USA.

Background: We conducted a retrospective cohort study of thirty-day readmission after abdominal aortic aneurysm (AAA) repair.

Patients And Methods: Inpatients (2009-2016) undergoing elective AAA repair were selected from the multicenter Cerner Health Facts® database using ICD-9 procedure codes. We identified characteristics associated with 30-day readmission with chi-square analysis and logistic regression. Read More

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December 2018

Assessment of the Safety of the New Hybrid Pencil Type Energy (NP) Device Used Close to the Recurrent Laryngeal Nerve in a Porcine Model: Comparison With a Conventional Electrosurgical Knife.

Surg Innov 2018 Dec 12:1553350618817646. Epub 2018 Dec 12.

1 Keio University, School of Medicine Tokyo, Japan.

Background: Recurrent laryngeal nerve (RLN) paralysis is mainly associated with esophagectomy, and it may result in not only other morbidities, such as aspiration pneumonia, but also in long-term issues. Therefore, an approach to prevent RLN paralysis is necessary. The present study was designed to determine the technical usability of the new hybrid pencil type energy (NP) device developed by Olympus Corporation (Tokyo, Japan) and compare it with a conventional electrosurgical knife (EK) for resection around the RLN lymph nodes. Read More

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December 2018

Immune-Related Adverse Events: Pneumonitis.

Adv Exp Med Biol 2018 ;995:131-149

Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Checkpoint inhibitors are part of the family of immunotherapies and are increasingly being used in a wide variety of cancers. Immune-related adverse events pose a major challenge in the treatment of cancer patients. Pneumonitis is a rare immune-related adverse event that presents in distinct patterns. Read More

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January 2018

Cost-Effectiveness of the Pneumococcal Conjugate Vaccine (10- or 13-Valent) Versus No Vaccination for a National Immunization Program in Tunisia or Algeria.

Infect Dis Ther 2018 Dec 11. Epub 2018 Dec 11.

Pfizer, Collegeville, PA, USA.

Introduction: To evaluate the expected impact of the Algeria national immunization program (NIP) and potential impact for a Tunisia NIP, this study assessed the public health and economic value of vaccination, through a cost-effectiveness analysis, for a PCV13 or PCV10 NIP, compared with no vaccination.

Methods: A decision-analytic model was programmed in Microsoft Excel™ and adapted to evaluate the clinical and economic outcomes of PCV vaccination. Assuming a steady state, the model estimated invasive pneumococcal disease (IPD; bacteremia and meningitis), all-cause pneumonia (inpatient and outpatient), and all-cause otitis media cases as well as the associated costs from a payer perspective. Read More

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December 2018

Probiotics for preventing postoperative infection in colorectal cancer patients: a systematic review and meta-analysis.

Int J Colorectal Dis 2018 Dec 11. Epub 2018 Dec 11.

Center for Disease Prevention and Control of Beijing Military Region, Beijing, 100042, China.

Purpose: Postoperative infection has seriously affected the prognosis of cancer patients, while probiotics have been increasingly used to prevent postoperative infection in clinical practice. This study aimed to evaluate the preventive effect of probiotics on infection after colorectal cancer (CRC) surgery.

Methods: Related clinical trial reports were collected from Pubmed, Embase, Cochrane Library as well as China National Knowledge Infrastructure (CNKI) databases. Read More

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December 2018

Delafloxacin meglumine for the treatment of acute bacterial skin and skin structure infections (ABSSSI).

Drugs Today (Barc) 2018 Nov;54(11):657-666

Division of Microbiology, CSIR-Central Drug Research Institute, Lucknow, India.

Delafloxacin meglumine (Baxdela, WQ-3034, ABT-492, RX-3341; Melinta Therapeutics) was approved by the U.S. Food and Drug Administration (FDA) in June 2017 for the treatment of acute bacterial skin and skin structure infections on the basis of data from two phase III trials. Read More

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November 2018
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High-Temperature Short-Time Treatment of Human Milk for Bacterial Count Reduction.

Front Pediatr 2018 27;6:359. Epub 2018 Nov 27.

Center for Pediatrics, Department of Neonatology, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.

Human milk (HM) for preterm infants will often be pasteurized for cytomegalovirus (CMV) inactivation and reduction of its bacterial count. High-temperature short-time (HTST) treatment compared to standard Holder pasteurization (HoP) reduces the impact of heat treatment on bioactive HM proteins while effectively inactivating CMV. No data are available for the efficacy of bacterial count reduction using HTST treatments that are available for clinical use. Read More

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November 2018

The Role of Pneumococcal Virulence Factors in Ocular Infectious Diseases.

Interdiscip Perspect Infect Dis 2018 13;2018:2525173. Epub 2018 Nov 13.

Department of Microbiology and Immunology, University of Mississippi Medical Center, Jackson, MS 39216, USA.

is a gram-positive, facultatively anaerobic pathogen that can cause severe infections such as pneumonia, meningitis, septicemia, and middle ear infections. It is also one of the top pathogens contributing to bacterial keratitis and conjunctivitis. Though two pneumococcal vaccines exist for the prevention of nonocular diseases, they do little to fully prevent ocular infections. Read More

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November 2018

Clinical characteristics and antimicrobial resistance of pneumococcal isolates of pediatric invasive pneumococcal disease in China.

Infect Drug Resist 2018 26;11:2461-2469. Epub 2018 Nov 26.

Department of Pediatrics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China,

Purpose: causes serious infections globally, including invasive pneumococcal disease (IPD). We analyze clinical features of pediatric IPD cases identified in China and antibiotic susceptibility of isolated pneumococcal strains.

Methods: Confirmed pediatric IPD patients were prospectively recruited to the study. Read More

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November 2018

-Containing Vacuoles Capture PtdIns(4)-Rich Vesicles Derived from the Golgi Apparatus.

MBio 2018 Dec 11;9(6). Epub 2018 Dec 11.

Institute of Medical Microbiology, University of Zürich, Zürich, Switzerland

is the causative agent of a pneumonia termed Legionnaires' disease. The facultative intracellular bacterium employs the Icm/Dot type IV secretion system (T4SS) and a plethora of translocated "effector" proteins to interfere with host vesicle trafficking pathways and establish a replicative niche, the -containing vacuole (LCV). Internalization of the pathogen and the events immediately ensuing are accompanied by host cell-mediated phosphoinositide (PI) lipid changes and the Icm/Dot-controlled conversion of the LCV from a PtdIns(3)-positive vacuole into a PtdIns(4)-positive replication-permissive compartment, which tightly associates with the endoplasmic reticulum. Read More

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December 2018

Tailoring Empirical Antimicrobial Therapy in Subjects With Ventilator-Associated Pneumonia With a 10-Hour E-Test Approach.

Respir Care 2018 Dec 11. Epub 2018 Dec 11.

Univ. de Bordeaux, UMR 5234 CNRS 'Microbiologie Cellulaire et Moléculaire et Pathogénicité'', Bordeaux, France.

Background: In a previous study of subjects suspected of having ventilator-associated pneumonia, a rapid susceptibility testing approach by using ETEST (BioMérieux) strips directly applied to bronchoalveolar lavage samples provided valuable information at hour 24. The primary objective of this study was to assess a new direct specimen testing by using an even more-rapid E-test approach (at hour 10), which could promote an early de-escalation of the antimicrobial therapy.

Methods: Twenty-eight subjects with ventilator-associated pneumonia admitted to a medical ICU were prospectively included. Read More

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December 2018

A pneumococcal purulent pericarditis revealing a pneumonia and complicated by an acute cardiac tamponade.

J Cardiol Cases 2012 Feb 4;5(1):e61-e64. Epub 2011 Nov 4.

Cardiology Department, Hôpital André Grégoire, 55 boulevard Boissière, 93100 Montreuil sous Bois, France.

Purulent pericarditis secondary to pneumococcal pneumonia is a rare entity, and often underestimated despite being associated with a high mortality rate. We report a case of a man who developed a cardiac tamponade related to a previously unknown pneumococcal pneumonia. In conclusion, we emphasize the need of repeated clinical and echocardiographic exams. Read More

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February 2012

Transient left ventricular dysfunction associated with severe infection.

J Cardiol Cases 2011 Apr 18;3(2):e78-e81. Epub 2011 Feb 18.

Division of Cardiology, Niigata University School of Medical and Dental Sciences, Niigata, Japan.

infection, although commonly seen as pneumonia, can also manifest systemic involvement. Here, we describe a case of sporadic infection coinciding with pneumonia, rhabdomyolysis, renal failure, and severe left ventricular dysfunction, which subsequently developed refractory septic shock. An endomyocardial biopsy revealed no findings of interstitial inflammatory infiltrates. Read More

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Torsades de pointes induced by garenoxacin in association with pacing failure in an elderly woman with VDD pacemaker.

J Cardiol Cases 2011 Apr 20;3(2):e62-e64. Epub 2011 Feb 20.

Division of Cardiology, Shizuoka Red Cross Hospital, 8-2 Otemachi Aoiku, Shizuoka 420-0853, Japan.

An 86-year-old woman was admitted to the hospital for syncope and convulsion 4 days after starting antibiotic therapy for pneumonia with oral garenoxacin 400 mg/day. She had a VDD pacemaker for complete atrioventricular (AV) block. Her electrocardiogram showed marked QT prolongation and during pacemaker interrogation pacing failure probably due to battery depletion induced torsades de pointes. Read More

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A case of acute coronary syndrome caused by extrinsic compression of the left main coronary artery due to pulmonary hypertension.

J Cardiol Cases 2010 Dec 3;2(3):e154-e158. Epub 2010 Aug 3.

Department of Cardiology, Cardiovascular Center, Tsuchiya General Hospital, 3-30 Nakajimacho Nakaku, Hiroshima City 730-8655, Japan.

Stenosis of the left main coronary artery (LMCA) due to extrinsic compression, producing symptoms of myocardial ischemia, is called left main compression syndrome. We report on a 43-year-old male with acute coronary syndrome who developed left main compression syndrome while waiting for a lung transplantation secondary to interstitial pneumonia, but underwent successful LMCA stenting as emergent treatment. Coronary angiography 3 months after the operation showed good stent patency in the LMCA, and the clinical course was favorable. Read More

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December 2010

Human rhinovirus infections in hematopoietic cell transplant recipients: risk score for progression to lower respiratory tract infection.

Biol Blood Marrow Transplant 2018 Dec 8. Epub 2018 Dec 8.

Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N Seattle, WA 98109. Electronic address:

Human rhinovirus lower respiratory tract infection is associated with mortality following hematopoietic cell transplantation; however, risk factors for lower respiratory tract infection are not well characterized. We sought to develop a risk score for progression to lower respiratory tract infection from upper respiratory tract infection in hematopoietic cell transplantation recipients. Risk factors for lower respiratory tract infection within 90 days were analyzed using Cox regression among hematopoietic cell transplantation recipients with rhinovirus upper respiratory tract infection between 1/2009-3/2016. Read More

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December 2018

Is continuous better than intermittent control of tracheal cuff pressure? A meta-analysis.

Nurs Crit Care 2018 Dec 9. Epub 2018 Dec 9.

Children's Hospital of Nanjing Medical University, Nanjing, China.

Aim: To compare and evaluate the efficacy and safety of continuous and intermittent control of P .

Methods: We performed a comprehensive and systematic meta-analysis of randomized controlled trials (RCTs) assessing the continuous and intermittent control of P by searching PUBMED, EMBASE and other such databases (from inception to 31 March 2018). Summary odds ratios or mean differences with 95% confidence intervals were calculated using a fixed- or random-effects model. Read More

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December 2018

Pneumococcal vaccination for welders: Global deployment within a multi-national corporation.

Am J Ind Med 2018 Dec 10. Epub 2018 Dec 10.

Alcoa Corporation, Pittsburgh, Pennsylvania.

Background: Lobar pneumonia is an occupational disease of welders. This is the first report of global deployment of a pneumococcal vaccination program for welders within a multi-national corporation.

Methods: Global webinars were conducted to introduce the program. Read More

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December 2018

Two-year prevalence of dysphagia and related outcomes in head and neck cancer survivors: An updated SEER-Medicare analysis.

Head Neck 2018 Dec 7. Epub 2018 Dec 7.

Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: The aim of the study was to examine prevalence of dysphagia at the population level in head and neck cancer (HNC) survivors.

Methods: Surveillance, Epidemiology, and End Results-Medicare claims among 16 194 patients with HNC (2002-2011) were analyzed to estimate 2-year prevalence of dysphagia, stricture, and aspiration pneumonia, and derive treatment- and site-specific estimates.

Results: Prevalence of dysphagia, stricture, pneumonia, and aspiration pneumonia was 45. Read More

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December 2018
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Prescribing trends and revisit rates following a pharmacist-driven protocol change for community-acquired pneumonia in an emergency department.

Int J Pharm Pract 2018 Dec 11. Epub 2018 Dec 11.

University of Pittsburgh Medical Center - Mercy Hospital, Pittsburgh, PA, USA.

Objective: To compare pharmacist-led prescribing changes and associated 30-day revisit rates across different regimens for patients discharged from an emergency department (ED) with a diagnosis of community-acquired pneumonia (CAP).

Methods: An observational, retrospective cohort analysis was conducted of patients who were discharged from an ED over a 4-year period with a diagnosis of CAP. Patient demographics, clinical characteristics, antibiotic selection and comorbidity and condition severity scores were collected for two cohorts: 2012-13 (before protocol change) and 2014-15 (post-protocol change). Read More

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December 2018

A novel biomarker of serum Histidine-Rich Glycoprotein (HRG) for diagnosing and predicting prognosis of ventilator-associated pneumonia (VAP): a pilot study.

Eur Rev Med Pharmacol Sci 2018 Nov;22(22):7920-7927

Department of Respiratory Medicine, Huzhou 3rd Hospital, Huzhou, Zhejiang, China.

Objective: Histidine-Rich Glycoprotein (HRG) has been reported to be associated with idiopathic pulmonary fibrosis, cancer, and sepsis as a novel biomarker. However, there is limited evidence regarding its value in diagnosing or prognosis evaluating of ventilator-associated pneumonia (VAP).

Patients And Methods: A total of 186 patients intubated in ICU and 65 healthy volunteers were enrolled in this study. Read More

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November 2018

[Acute dystonia in a patient with an elevated clozapine level due to an infection].

Tijdschr Psychiatr 2018 ;60(12):843-847

Acute dystonia is a side-effect associated with the use of antipsychotics. We describe the case of a 75-year-old patient with late-onset schizophrenia who used clozapine. During a hospital admission due to pneumonia, she developed a form of acute dystonia consisting of a rotational torticollis, which disappeared rapidly after treatment with biperiden. Read More

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January 2018
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Etiology and prognosis of acute respiratory failure in patients with primary malignant brain tumors admitted to the intensive care unit.

J Neurooncol 2018 Dec 7. Epub 2018 Dec 7.

Sorbonne Universités, UPMC Univ Paris 06, INSERM, UMRS_1158 Neurophysiologie respiratoire expérimentale et clinique, Paris, France.

Purpose: Acute respiratory failure (ARF) is common and potentially fatal in patients with primary malignant brain tumors (PMBT). However, few data are available regarding its precipitating factors and prognosis. We sought to: (1) compare the causes of ARF and the outcome between patients with PMBT and patients with other peripheral solid tumors (PST), (2) identify the factors influencing ICU survival in PMBT patients. Read More

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December 2018

Risk factors for progression and prognosis of rheumatoid arthritis-associated interstitial lung disease: single center study with a large sample of Chinese population.

Clin Rheumatol 2018 Dec 7. Epub 2018 Dec 7.

Department of Rheumatology and Immunology, Beijing Chao-Yang Hospital West Hospital, Capital Medical University, No. 8 Gong-Ti South Road, Chao yang District, Beijing, China.

Background: Factors associated with progression and survivals in rheumatoid arthritis-associated interstitial lung disease (RA-ILD) have not been described in a large center China cohort.

Methods: Seven-hundred and ninety-one consecutive RA patients who completed lung HRCT were considered as potential participants in this retrospective cohort study. Determinants of ILD progression were identified through multivariable logistic analysis. Read More

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December 2018
1.774 Impact Factor

Detection and identification of fungi in bronchoalveolar lavage fluid from immunocompromised patients using panfungal PCR.

Folia Microbiol (Praha) 2018 Dec 8. Epub 2018 Dec 8.

Department of Internal Medicine - Hematology and Oncology, University Hospital Brno, Brno, Czech Republic.

Rapid diagnostics of fungal pneumonia and initiation of appropriate therapy are still challenging. In this study, we used two panfungal assays to test bronchoalveolar lavage fluid (BALF) samples to prove their ability to confirm invasive fungal disease diagnosis and identify causative agents. Two methods targeting different fungal rDNA regions were used, and the obtained PCR products were sequenced directly or after cloning. Read More

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December 2018

Does pyloric drainage have a role in the era of minimally invasive esophagectomy?

Surg Endosc 2018 Dec 10. Epub 2018 Dec 10.

Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Introduction: Pyloric drainage during minimally invasive esophagectomy (MIE) may be more technically challenging than with an open approach. Alternatives to classic surgical drainage have increased in popularity; however, data are lacking to demonstrate whether one technique is superior in MIE. The purpose of this study was to compare post-operative outcomes after MIE between different pyloric drainage methods. Read More

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December 2018

Early extubation followed by immediate noninvasive ventilation vs. standard extubation in hypoxemic patients: a randomized clinical trial.

Intensive Care Med 2018 Dec 10. Epub 2018 Dec 10.

Anestesia e Rianimazione, Dipartimento di Scienze Mediche e Chirurgiche, Università "Magna Graecia", Viale Europa (Loc. Germaneto), Catanzaro, Italy.

Purpose: Noninvasive ventilation (NIV) may facilitate withdrawal of invasive mechanical ventilation (i-MV) and shorten intensive care unit (ICU) length of stay (LOS) in hypercapnic patients, while data are lacking on hypoxemic patients. We aim to determine whether NIV after early extubation reduces the duration of i-MV and ICU LOS in patients recovering from hypoxemic acute respiratory failure.

Methods: Highly selected non-hypercapnic hypoxemic patients were randomly assigned to receive NIV after early or standard extubation. Read More

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December 2018

MicroRNA‑124‑3p attenuates severe community‑acquired pneumonia progression in macrophages by targeting tumor necrosis factor receptor‑associated factor 6.

Int J Mol Med 2018 Dec 3. Epub 2018 Dec 3.

Department of Critical Care Medicine, The Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China.

Community‑acquired pneumonia (CAP) is a severe type of pneumonia in adults, with a high mortality rate. Macrophages have been reported to mediate severe CAP (SCAP) in vitro following administration of LPS. Therefore, the present study established a SCAP model in Ana‑1 macrophages by lipopolysaccharide (LPS) induction, and aimed to explore the function of microRNA (miR)‑124‑3p in the LPS‑induced SCAP. Read More

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December 2018

Exploring Standard Endpoints for Clinical Trials of Pneumonia Therapy.

Authors:
Joshua C Eby

J Infect Dis 2018 Dec 10. Epub 2018 Dec 10.

Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA, USA.

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December 2018

Pharmacokinetic evaluation of linezolid administered intravenously in obese patients with pneumonia.

J Antimicrob Chemother 2018 Dec 7. Epub 2018 Dec 7.

Laboratory of Medical Biochemistry and Clinical Analysis, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, Ghent, Belgium.

Objectives: Altered linezolid pharmacokinetics (PK) in obese individuals has been hypothesized in previous studies. However, specific dosing recommendations for this population are still lacking. The main goal of this study was to evaluate PK/pharmacodynamic (PKPD) target attainment when using a 600 mg intravenous q12h linezolid dose against MRSA in obese patients with pneumonia. Read More

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December 2018

Diagnostic accuracy of the 1,3-β-D-glucan test for pneumocystis pneumonia in a tertiary university hospital in Denmark: A retrospective study.

Med Mycol 2018 Dec 11. Epub 2018 Dec 11.

Department of Clinical Microbiology, Copenhagen University Hospital Rigshospitalet, Denmark.

1,3-β-D-glucan (BG), a cell-wall component of most fungi including Pneumocystis (PC), is recommended by international guidelines for screening for pneumocystis pneumonia (PCP) in hematologic patients. We retrospectively validated the BG test in our tertiary university hospital. Forty-five patients (median age 53 years, 33% female) tested for PC by polymerase chain reaction (PCR) and/or immunoflourescence (IF)-microscopy with a stored blood sample within ±5 days of the PC test were tested by the Fungitell (cutoff <60 and >80 pg/ml). Read More

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December 2018

Comparison of Antibiotic Prescribing for Pediatric Community-Acquired Pneumonia in Children's and Non-Children's Hospitals.

JAMA Pediatr 2018 Dec 10. Epub 2018 Dec 10.

Division of Infectious Diseases, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia.

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December 2018

[Cryptococcosis in Hospital Carlos Van Buren, Valparaiso: a clinical serie].

Rev Chilena Infectol 2018 Aug;35(4):420-423

Universidad de Valparaíso, Valparaíso, Chile.

Background: Cryptococcosis is a severe opportunistic mycotic infection, caused mainly by Cryptococcus neoformans. It can present as meningitis, pneumonia or cryptococcemia.

Aim: To characterize patients with Cryptococcus infection between January 1°, 2013 and June 30, 2016, in Hospital Carlos van Buren, Valparaíso, Chile. Read More

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[Bacteremic pneumococcal pneumonia in adults admitted to a general hospital. Experience in 60 cases].

Rev Med Chil 2018 Jul;146(7):839-845

Facultad de Medicina, Universidad San Sebastián, Patagonia, Chile.

Background: Bacteremic pneumococcal pneumonia (BPP) is a preventable disease with high morbimortality.

Aim: To evaluate clinical aspects and mortality on BPP patients admitted to a Chilean regional hospital.

Patients And Methods: We looked for adult patients with Streptococcus pneumoniae isolated from blood cultures between 2010 and 2014 years and reviewed clinical records of those who were admitted with pneumonia. Read More

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Screening for Humoral Immunodefi ciency in Patients with Community-Acquired Pneumonia.

J Hosp Med 2018 Nov 28. Epub 2018 Nov 28.

Rochester Regional Health, Rochester, New York, USA.

Background: Immunodeficiency is an underrecognized risk factor for infections, such as community-acquired pneumonia (CAP).

Objective: We evaluated patients admitted with CAP for humoral immunodeficiency.

Design: Prospective Cohort Study. Read More

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November 2018

A rare case of lipoid pneumonia attributed to amiodarone.

Pneumonia (Nathan) 2018 5;10:12. Epub 2018 Dec 5.

Department of Pneumonology, Sotiria Hospital, Athens, Greece.

We report a case of endogenous lipoid pneumonia secondary to long-term use of amiodarone (> 30 years) for atrial fibrillation in a 76-year-old Caucasian woman, presenting with cough and dyspnea. Endogenous Lipoid pneumonia is a rare underdiagnosed condition more prevalent in adults. It is usually asymptomatic and a diagnosis is generally made in patients who have become clinically unstable or when an abnormal lung shadow is found on a chest X-ray. Read More

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December 2018

Draft Genome Sequences of Two Pseudomonas aeruginosa Multidrug-Resistant Clinical Isolates, PAL0.1 and PAL1.1.

Microbiol Resour Announc 2018 Nov 1;7(17). Epub 2018 Nov 1.

Host-Pathogens Translational Research Group, Faculty of Medicine of Lille, University of Lille Nord de France, Lille, France.

Pseudomonas aeruginosa infections are challenging due to intrinsic and acquired resistance mechanisms. We report here the draft genome sequences of two multidrug-resistant strains-PAL0.1, isolated from the airways of an intensive care unit (ICU) patient with ventilator-associated pneumonia, and PAL1. Read More

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November 2018

A successful treatment of rheumatoid arthritis-related interstitial pneumonia with nintedanib.

Respir Med Case Rep 2019 1;26:50-52. Epub 2018 Nov 1.

Department of Respiratory Medicine, National Center for Global Health and Medicine, Japan.

Rheumatoid arthritis-related interstitial pneumonia with a usual interstitial pneumonia (RA-UIP) has a poor prognosis and a new treatment strategy is required. The antifibrotic agent nintedanib reduces the annual rate of decline in forced vital capacity (FVC) in idiopathic pulmonary fibrosis (IPF) patients. Recently, the potential efficacy of antifibrotic agents against chronic progressive fibrotic diseases including RA-UIP has been attracting attention. Read More

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November 2018

An increase in mean platelet volume during admission can predict the prognoses of patients with pneumonia in the intensive care unit: A retrospective study.

PLoS One 2018 11;13(12):e0208715. Epub 2018 Dec 11.

Department of Pulmonary and Critical Care Medicine, Chugnam National University Medical College and Hospital, Daejeon, Korea.

Platelets play an important role in hemostasis, inflammation, and immunity. Mean platelet volume (MPV), considered a marker of platelet function and activation, is associated with increased morbidity and mortality in sepsis, coronary artery disease, and chronic inflammatory disease. However, the clinical characteristics and prognostic significance of MPV changes for patients with pneumonia in the intensive care unit (ICU) have not been investigated. Read More

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December 2018

Posture and firmness changes in a pressure-relieving air mattress affect cough strength in elderly people with dysphagia.

PLoS One 2018 11;13(12):e0208895. Epub 2018 Dec 11.

Department of Physical Analysis and Therapeutic Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Dysphagia is the major pathophysiologic mechanism leading to aspiration pneumonia in the elderly. Elderly people with dysphagia who show low levels of the cough peak flow (CPF) are at greater risk for aspiration pneumonia. It has been reported that CPF values were significantly lower in the "soft" versus "hard" mode of a pressure-relieving air mattress in healthy volunteers in a supine position. Read More

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December 2018
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Health care-associated infections - an overview.

Infect Drug Resist 2018 15;11:2321-2333. Epub 2018 Nov 15.

Faculty of Medicine and Defence Health, Universiti Pertahanan Nasional Malaysia (National Defence University of Malaysia), Kem Sungai Besi, 57000 Kuala Lumpur, Malaysia,

Health care-associated infections (HCAIs) are infections that occur while receiving health care, developed in a hospital or other health care facility that first appear 48 hours or more after hospital admission, or within 30 days after having received health care. Multiple studies indicate that the common types of adverse events affecting hospitalized patients are adverse drug events, HCAIs, and surgical complications. The US Center for Disease Control and Prevention identifies that nearly 1. Read More

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November 2018

Comparative efficacy of modified-live and inactivated vaccines in boosting responses to bovine respiratory syncytial virus following neonatal mucosal priming of beef calves.

Can Vet J 2018 Dec;59(12):1311-1319

Departments of Veterinary Microbiology (Ellis, Lacoste) and Large Animal Clinical Sciences (Gow, Berenik, Erickson), Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4.

Bovine respiratory syncytial virus (BRSV) is the leading cause of viral pneumonia in calves, making young passively immune calves candidates for vaccination, and raising issues concerning boosting of neonatally primed responses. To address this, 18, 2-month-old Angus-cross passively immune beef heifer calves that had been primed at birth with a combination viral intranasal vaccine were administered either a parenteral combination vaccine containing modified-live (MLV) BRSV or a similar vaccine containing inactivated BRSV. At 6 months of age, these calves and 2 controls that received only the MLV at 2 months of age were challenged with BRSV aerosol. Read More

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December 2018

Asymptomatic carriage of Streptococcus pneumoniae detected by qPCR on the palm of hands of populations in rural Senegal.

PLoS Negl Trop Dis 2018 Dec 10;12(12):e0006945. Epub 2018 Dec 10.

Aix-Marseille Univ, IRD, AP-HM, SSA, IHU-Méditerranée Infection, UMR Vecteurs-,InfectionsTropicales et Mediterranéennes (VITROME), Marseille, France.

Aside from malaria, infectious diseases are an important cause of death in sub-Saharan Africa and continue to pose major public health problems in African countries, notably pneumonia. Streptococcus pneumoniae remains the most common bacterial cause of pneumonia in all age groups. The skin is one of the main infection sites followed by the oropharynx. Read More

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December 2018

[Efectos sobre el perfil metabólico, el índice de masa corporal, la composición corporal y la comorbilidad en adolescentes con obesidad mórbida, que han fallado al manejo conservador para bajar de peso, operados de manga gástrica laparoscópica. Reporte del primer grupo de cirugía bariátrica pediátrica en México].

Gac Med Mex 2018 ;154(Supp 2):S22-S29

Departamento de Endocrinología. Hospital Infantil de México Federico Gómez, Ciudad de México, México.

Introduction: Obesity is a world pandemic; in Mexico 3 out of 10 adolescents suffer from it. Conservative management of morbid obesity is not effective and bariatric surgery is the only useful therapy. International pediatric bariatric surgery series are scarce and in Mexico there is limited experience. Read More

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January 2018

[Results of a single-centre study of open and endovascular operations of prosthetic repair of abdominal aortic aneurysms].

Angiol Sosud Khir 2018 ;24(4):126-130

National Medical Research Centre named after V.A. Almazov under the RF Ministry of Public Health, Saint Petersburg, Russia.

Objective: The purpose of the study was to assess surgical outcomes in patients suffering from an infrarenal abdominal aortic aneurysm and treated at the Department of Cardiovascular Surgery #2 of the National Medical Research Centre named after V.A. Almazov. Read More

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January 2018

Functional Status is Associated With 30-Day Potentially Preventable Readmissions Following Home Health Care.

Med Care 2018 Dec 10. Epub 2018 Dec 10.

Division of Rehabilitation Sciences.

Background: Beginning in 2019, home health agencies' rates of potentially preventable hospital readmissions over the 30 days following discharge will be publicly reported.

Objectives: Our primary objective was to determine the association between patients' functional status at discharge from home health care and 30-day potentially preventable readmissions. A secondary objective was to identify the most common conditions resulting in potentially preventable readmissions. Read More

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December 2018
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Symptomatic HIV-Infected Patients Have Poorer Outcomes Following Emergency General Surgery: A Study of the Nationwide Inpatient Sample.

J Trauma Acute Care Surg 2018 Dec 5. Epub 2018 Dec 5.

Department of Surgery, Section of General Surgery, Trauma, and Surgical Critical Care, Yale School of Medicine, New Haven, CT USA.

Background: The impact of HIV infection on outcomes following common emergency general surgery procedures has not been evaluated since the widespread introduction of highly-active antiretroviral therapy (HAART).

Methods: A retrospective cohort study was conducted using the Nationwide Inpatient Sample. Records of patients who underwent laparoscopic or open appendectomy, cholecystectomy, or colon resection after emergency admission from 2004-2011 were obtained. Read More

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December 2018

Three-legged radiographic view for evaluating cranioventral lung region in standing calves with bovine respiratory disease.

J Vet Med Sci 2018 Dec 7. Epub 2018 Dec 7.

Veterinary Medical Center, Obihiro University of Agriculture and Veterinary Medicine.

This study proposed a novel radiographic positioning in order to image the cranioventral lung region using a portable X-ray unit and digital radiography system. In the novel position, calves were restrained in a chute and a unilateral forelimb was pulled cranially with the contralateral forelimb tied to the chute; the forelimbs were then spread cranio-caudally as in a scissor position (Three-legged view: TL view). In a preliminary study, we applied the TL view for imaging of 14 clinically healthy calves. Read More

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December 2018