34,790 results match your criteria Pneumonia Fungal


Staphylococcus aureus versus neutrophil: Scrutiny of ancient combat.

Microb Pathog 2019 Apr 16. Epub 2019 Apr 16.

Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Staphylococcus aureus (S.aureus) is a Gram-positive bacterium that causes many infections and diseases. This pathogen can cause many types of infections such as impetigo, toxic shock syndrome toxin (TSST1), pneumonia, endocarditis, and autoimmune diseases like lupus erythematosus and can infect other healthy individuals. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08824010193037
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http://dx.doi.org/10.1016/j.micpath.2019.04.026DOI Listing
April 2019
1 Read

Prevalence of health care-associated infections and antimicrobial resistance of the responsible pathogens in Ukraine: Results of a multicenter study (2014-2016).

Am J Infect Control 2019 Apr 15. Epub 2019 Apr 15.

Department of Anatomy, Topographical Anatomy, and Operative Surgery, Private Higher Educational Establishment "Kyiv Medical University," Kyiv, Ukraine.

Background: The aim of this study was to obtain the first national estimates of the current prevalence and incidence and death of health care-associated infections (HAIs) of all types in acute care hospitals in Ukraine.

Methods: Prospective surveillance was conducted from January 2014 to December 2016 in 17 hospitals. Surveillance case definitions were derived from the Centers for Disease Control and Prevention's National Healthcare Safety Network HAI case definitions. Read More

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http://dx.doi.org/10.1016/j.ajic.2019.03.007DOI Listing

Co-infection with bacterial and fungal endocarditis at scar tissue in an immunocompromised patient.

J Cardiol Cases 2019 Apr 17;19(4):117-120. Epub 2018 Dec 17.

Antimicrobial Resistance Research Center, Iran University of Medical Sciences, Tehran, Iran.

We present the case of a 65-year-old immunocompromised male with a history of kidney transplantation, diabetes, coronary artery bypass, and cardiac resynchronization therapy device implantation who was finally diagnosed with an unusual form of infective endocarditis due to co-infection of fungal and bacterial pathogens. He was afebrile at the time of admission and presented with decompensated heart failure and pneumonia. A spleen abscess was discovered incidentally and prompted us to search for a cardiac source of emboli. Read More

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http://dx.doi.org/10.1016/j.jccase.2018.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451046PMC

[Exogenous lipoid pneumonia induced by long-term usage of compound menthol nasal drops: a case report].

Authors:
M Lu W Yan X Zhu H Zhu

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):359-361

Department of Respiratory Medicine, Peking University Third Hospital, Beijing 100191, China.

Here we reported a case of exogenous lipoid pneumonia from Peking University Third Hospital. A 62-year-old male presented with chronic cough and expectoration for 8 years, without chest pain, hemoptysis or short of breath. He was an ex-smoker. Read More

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-specific hyperimmune plasma administration decreases faecal shedding of pathogenic in foals.

Vet Rec 2019 Apr 17. Epub 2019 Apr 17.

Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington, USA.

is the most common cause of pneumonia in young foals. Pneumonic foals are an important source of environmental contamination as they shed higher amounts of in their faeces than unaffected foals. As -specific hyperimmune plasma (HIP) lessens clinical pneumonia, we hypothesise that its use would result in decreased faecal shedding of by foals. Read More

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http://veterinaryrecord.bmj.com/lookup/doi/10.1136/vr.105327
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http://dx.doi.org/10.1136/vr.105327DOI Listing
April 2019
1 Read

Antimicrobial agent susceptibilities of Legionella pneumophila MLVA-8 genotypes.

Sci Rep 2019 Apr 16;9(1):6138. Epub 2019 Apr 16.

Department of Evolutionary and Environmental Biology, Faculty of Natural Sciences, University of Haifa, Haifa, Israel.

Legionella pneumophila causes human lung infections resulting in severe pneumonia. High-resolution genotyping of L. pneumophila isolates can be achieved by multiple-locus variable-number tandem-repeat analysis (MLVA-8). Read More

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http://dx.doi.org/10.1038/s41598-019-42425-1DOI Listing

Micafungin prophylaxis for acute leukemia patients undergoing induction chemotherapy.

BMC Cancer 2019 Apr 16;19(1):358. Epub 2019 Apr 16.

Department of Internal Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 03080, South Korea.

Background: Micafungin is a well-tolerated and effective prophylactic antifungal agent used in hematologic diseases. In this prospective trial, we evaluated the efficacy and safety of prophylactic micafungin during first induction chemotherapy in patients with acute leukemia. We also compared outcomes of prophylactic micafungin with those of prophylactic posaconazole in acute myeloid leukemia (AML). Read More

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http://dx.doi.org/10.1186/s12885-019-5557-9DOI Listing
April 2019
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Respiratory tract virus infections in the elderly with pneumonia.

BMC Geriatr 2019 Apr 16;19(1):111. Epub 2019 Apr 16.

Department of Pediatrics and Adolescent Medicine, University of Turku and Turku University Hospital, PO Box 52, 20520, Turku, Finland.

Background: In children suffering from severe lower airway illnesses, respiratory virus detection has given good prognostic information, but such reports in the elderly are scarce. Therefore, our aim was to study whether the detection of nasopharyngeal viral pathogens and conventional inflammatory markers in the frail elderly correlate to the presence, signs and symptoms or prognosis of radiographically-verified pneumonia.

Methods: Consecutive episodes of hospital care of patients 65 years and older with respiratory symptoms (N = 382) were prospectively studied as a cohort. Read More

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https://bmcgeriatr.biomedcentral.com/articles/10.1186/s12877
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http://dx.doi.org/10.1186/s12877-019-1125-zDOI Listing
April 2019
5 Reads

The role of infection acquisition site and inappropriate empirical treatment on the outcome of extended-beta-lactamase producing Enterobacteriaceae infections.

Int J Antimicrob Agents 2019 Apr 12. Epub 2019 Apr 12.

Experimental and Clinical Medicine Department, Università degli Studi di Firenze, Florence, Italy; USC Microbiologia e Virologia, AOSP Papa Giovanni XXIII, Piazza OMS 1, Bergamo, Italy; Institute of Infectious Diseases, Catholic University of Rome, Rome, Italy; Clinical Microbiology and Virology Unit, Alessandro Manzoni Hospital, Lecco, Italy; Infectious Diseases Department, Azienda Socio Sanitaria Territoriale di Cremona, Cremona, Italy; Emergency Department, Azienda Socio Sanitaria Territoriale di Cremona, Cremona, Italy; Microbiology and Virology Unit, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.

Objectives: The impact of inappropriate empirical antibiotic therapy (IEAT) on the outcome of severe infections due to extended spectrum beta-lactamases producers Enterobacteriaceae (ESBL-Ent) remains under debate. Current evidence is limited by study design and lacking confounder control. The main objective of this study was to define the outcome of severe infections due to ESBL-Ent according to clinical parameters and place of acquisition. Read More

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http://dx.doi.org/10.1016/j.ijantimicag.2019.04.007DOI Listing

The Clinical Presentation of Pediatric Mycoplasma pneumoniae Infections-A Single Center Cohort.

Pediatr Infect Dis J 2019 Apr 10. Epub 2019 Apr 10.

From the Department of Clinical Microbiology and Infectious Diseases, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

Background: Mycoplasma pneumoniae (MP) is a major cause of community-acquired upper and lower respiratory infections in school-age children; however, there is increasing recognition that younger children are also affected. Clinical manifestations vary from asymptomatic, to severe complicated pneumonia sometimes with extrapulmonary manifestations.

Methods: We reviewed the medical records of all MP positive pediatric patients admitted to the Hadassah-Hebrew University Medical Center. Read More

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http://dx.doi.org/10.1097/INF.0000000000002291DOI Listing
April 2019
3 Reads

Yap/Taz regulate alveolar regeneration and resolution of lung inflammation.

J Clin Invest 2019 Apr 15;130. Epub 2019 Apr 15.

Department of Pharmacology, Center for Translational Medicine, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania, USA.

Alveolar epithelium plays a pivotal role in protecting the lungs from inhaled infectious agents. Therefore, the regenerative capacity of the alveolar epithelium is critical for recovery from these insults in order to rebuild the epithelial barrier and restore pulmonary functions. Here, we show that sublethal infection of mice with Streptococcus pneumoniae, the most common pathogen of community-acquired pneumonia, led to exclusive damage in lung alveoli, followed by alveolar epithelial regeneration and resolution of lung inflammation. Read More

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http://dx.doi.org/10.1172/JCI125014DOI Listing
April 2019
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[Infectious complications after kidney transplantation].

Nephrol Ther 2019 Apr;15 Suppl 1:S37-S42

Service de néphrologie et transplantation adulte, hôpital Necker Enfants Malades, Assistance publique-Hôpitaux de Paris, 149, rue de Sèvres, 75015 Paris, France; Université Paris Descartes Sorbonne Paris Cité, 12, rue de l'École-de-Médecine, 75006 Paris, France.

Infectious complications are one of the leading causes of hospitalization and mortality in kidney transplant recipients. They are more frequent during the year following transplantation, and in the elderly. Community infections, such as pyelonephritis and pneumonia, are from far the most common infections. Read More

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http://dx.doi.org/10.1016/j.nephro.2019.03.010DOI Listing

AMPs as Anti-biofilm Agents for Human Therapy and Prophylaxis.

Adv Exp Med Biol 2019 ;1117:257-279

Department of Microbiology and Parasitology, University of Navarra, Pamplona, Spain.

Microbial cells show a strong natural tendency to adhere to surfaces and to colonize them by forming complex communities called biofilms. In this growth mode, biofilm-forming cells encase themselves inside a dense matrix which efficiently protects them against antimicrobial agents and effectors of the immune system. Moreover, at the physiological level, biofilms contain a very heterogeneous cell population including metabolically inactive organisms and persisters, which are highly tolerant to antibiotics. Read More

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http://link.springer.com/10.1007/978-981-13-3588-4_14
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http://dx.doi.org/10.1007/978-981-13-3588-4_14DOI Listing
January 2019
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Disulfide bond of Mycoplasma pneumoniae community acquired respiratory distress syndrome toxin is essential to maintain the ADP-ribosylating and vacuolating activities.

Cell Microbiol 2019 Apr 11:e13032. Epub 2019 Apr 11.

Department of Microbiology, Immunology and Molecular Genetics, The University of Texas Health Science Center at San Antonio, TX.

Mycoplasma pneumoniae is the leading cause of bacterial community acquired pneumonia among hospitalized children in United States and worldwide. Community acquired respiratory distress syndrome (CARDS) toxin is a key virulence determinant of M. pneumoniae. Read More

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http://dx.doi.org/10.1111/cmi.13032DOI Listing
April 2019
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Pneumocystosis as a Complication of H1N1 Influenza A Infection in an HIV-Positive Patient on Effective cART.

Open Forum Infect Dis 2019 Apr 7;6(4):ofz105. Epub 2019 Mar 7.

Infectious Diseases Unit, University of Modena and Reggio Emilia, Modena, Italy.

H1N1 influenza A virus can affect the immune system, causing lymphopenia. This might be of great concern for HIV individuals undergoing effective antireroviral therapy (cART). We report the first confirmed case of H1N1-induced AIDS and pneumonia in an HIV-positive woman on effective cART since 2006. Read More

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http://dx.doi.org/10.1093/ofid/ofz105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453522PMC
April 2019
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Von Willebrand Factor Mediates Pneumococcal Aggregation and Adhesion in Blood Flow.

Front Microbiol 2019 26;10:511. Epub 2019 Mar 26.

Institute of Microbiology, Technische Universität Braunschweig, Braunschweig, Germany.

is a major cause of community acquired pneumonia and septicaemia in humans. These diseases are frequently associated with thromboembolic cardiovascular complications. Pneumococci induce the exocytosis of endothelial Weibel-Palade Bodies and thereby actively stimulate the release of von Willebrand factor (VWF), which is an essential glycoprotein of the vascular hemostasis. Read More

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http://dx.doi.org/10.3389/fmicb.2019.00511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443961PMC
March 2019
1 Read

causing pulmonary endobronchial - A case report.

Indian J Pathol Microbiol 2019 Apr-Jun;62(2):326-328

Department of Pulmonary Medicine, St. John's National Academy of Health Sciences, Koramangala, Bangalore, Karnataka, India.

Actinomyces naeslundii is a commensal flora of the oral cavity and is generally considered as an avirulent saprophytic bacterium in immunocompetent patients. It can become an opportunistic anaerobic pathogen in oral cavity in patients with poor oral hygiene or tooth extraction and can cause periodontal disease. Pulmonary Actinomycosis is a rare manifestation and may be suspected in middle-aged male patients with cough and hemoptysis showing radiological findings of a peripheral mass or chronic consolidation in whom repeated aerobic cultures have yielded negative results. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_706_17DOI Listing
April 2019
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Regenerative therapy based on miRNA-302 mimics for enhancing host recovery from pneumonia caused by .

Proc Natl Acad Sci U S A 2019 Apr 10. Epub 2019 Apr 10.

Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104;

Bacterial pneumonia remains a leading cause of morbidity and mortality worldwide. A defining feature of pneumonia is lung injury, leading to protracted suffering and vulnerability long after bacterial clearance. Little is known about which cells are damaged during bacterial pneumonia and if the regenerative process can be harnessed to promote tissue repair and host recovery. Read More

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http://dx.doi.org/10.1073/pnas.1818522116DOI Listing
April 2019
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Adenovirus type 5 community-acquired pneumonia in an immunocompetent patient.

BMJ Case Rep 2019 Apr 8;12(4). Epub 2019 Apr 8.

Department of Microbiology, Tokyo Medical University, Tokyo, Japan.

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http://dx.doi.org/10.1136/bcr-2018-228914DOI Listing
April 2019
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φSa3mw Prophage as a Molecular Regulatory Switch of β-toxin Production.

J Bacteriol 2019 Apr 8. Epub 2019 Apr 8.

Department of Microbiology and Immunology, University of Iowa, Roy J. and Lucille A. Carver College of Medicine, Iowa City, Iowa, USA

Phage regulatory switches (phage-RSs) are a newly described form of active lysogeny where prophages function as regulatory mechanisms for expression of chromosomally-encoded, bacterial genes. In φSa3int is a widely-distributed family of prophages that integrate into the β-toxin structural gene effectively inactivating it. However, β-toxin producing strains often arise during infections and are more virulent in experimental infective endocarditis and pneumonia infections. Read More

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http://jb.asm.org/lookup/doi/10.1128/JB.00766-18
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http://dx.doi.org/10.1128/JB.00766-18DOI Listing
April 2019
5 Reads

Community-acquired Pneumonia and Hospital-acquired Pneumonia.

Med Clin North Am 2019 May 7;103(3):487-501. Epub 2019 Mar 7.

Division of Respiratory and Critical Care Physiology and Medicine, Harbor-UCLA Medical Center, 1000 West Carson Street, Box 402, Torrance, CA 90509, USA.

Pneumonia is among the leading causes of morbidity and mortality worldwide. Although Streptococcus pneumoniae is the most likely cause in most cases, the variety of potential pathogens can make choosing a management strategy a complex endeavor. The setting in which pneumonia is acquired heavily influences diagnostic and therapeutic choices. Read More

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http://dx.doi.org/10.1016/j.mcna.2018.12.008DOI Listing
May 2019
1 Read

Persistent hematogenous dissemination in pulmonary P. jiroveci infection.

Mycopathologia 2019 Apr 6. Epub 2019 Apr 6.

Infectious Diseases Division, Santa Maria della Misericordia University Hospital, Udine, Italy.

Pneumocystis jiroveci pneumonia in non-HIV patients is infrequent and characterized by atypical presentations and increased severity. Although hematogenous dissemination from the lungs can lead to extrapulmonary infections, isolation of oocysts from blood in human subjects has not been documented. We report a case of P. Read More

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http://dx.doi.org/10.1007/s11046-019-00332-zDOI Listing

: escape room world champion.

Pneumonia (Nathan) 2019 24;11. Epub 2019 Mar 24.

1Department of Sciences, University College Roosevelt, P.O. Box 94, 4330 Middelburg, AB Netherlands.

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http://dx.doi.org/10.1186/s41479-019-0060-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431426PMC
March 2019
1 Read

Impact of angiotensin-converting enzyme inhibitors and statins on viral pneumonia.

Proc (Bayl Univ Med Cent) 2018 Oct 26;31(4):419-423. Epub 2018 Oct 26.

Division of Pulmonary, Critical Care, and Sleep Medicine, Baylor Scott & White HealthTempleTexas.

Angiotensin-converting enzyme (ACE) inhibitors and statins may potentially benefit patients with viral infections and pneumonia. Our study aimed to evaluate the impact of ACE inhibitors and statins on the rates of intubation and death in viral pneumonia. We retrospectively studied 1055 adult patients admitted to a tertiary care center in central Texas with a positive respiratory viral polymerase chain reaction test. Read More

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http://dx.doi.org/10.1080/08998280.2018.1499293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414001PMC
October 2018
2 Reads

Human bocaviruses and paediatric infections.

Lancet Child Adolesc Health 2019 Apr 1. Epub 2019 Apr 1.

Department of Paediatrics, Turku University Hospital and University of Turku, Turku, Finland.

Human bocavirus 1 (HBoV1), belonging to the Parvoviridae family, was discovered in 2005, in nasopharyngeal samples from children with respiratory tract infections. Three additional bocaviruses, HBoV2-4, were discovered in 2009-10. These viruses have mainly been found in faecal samples and their role in human diseases is still uncertain. Read More

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http://dx.doi.org/10.1016/S2352-4642(19)30057-4DOI Listing
April 2019
2 Reads

Epidemiology of invasive and non-invasive pneumococcal infections in hospitalised adult patients in a Lebanese medical centre, 2006-2015.

J Infect Public Health 2019 Apr 1. Epub 2019 Apr 1.

Centre for Infectious Diseases Research, American University of Beirut, Riad El-Solh, Beirut, Lebanon; Department of Paediatrics and Adolescent Medicine, Division of Paediatric Infectious Diseases, American University of Beirut, Riad El-Solh, Beirut, Lebanon; Department of Biochemistry and Molecular Genetics, American University of Beirut, Riad El-Solh, Beirut, Lebanon. Electronic address:

This is a retrospective medical file review of adult inpatients with Streptococcus pneumoniae infections admitted to a Lebanese hospital between 2006 and 2015. We revisited the clinical scenarios of these infections in view of increasing antibiotic resistance in Lebanon. One hundred and three patients were included; 92% were eligible for pneumococcal vaccination, yet none were vaccinated. Read More

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http://dx.doi.org/10.1016/j.jiph.2019.03.003DOI Listing

Sequential organ failure assessment score is an excellent operationalization of disease severity of adult patients with hospitalized community acquired pneumonia - results from the prospective observational PROGRESS study.

Crit Care 2019 Apr 4;23(1):110. Epub 2019 Apr 4.

University of Leipzig, Institute for Medical Informatics, Statistics and Epidemiology (IMISE), Härtelstr. 16-18, 04107, Leipzig, Germany.

Background: CAP (Community acquired pneumonia) is frequent, with a high mortality rate and a high burden on health care systems. Development of predictive biomarkers, new therapeutic concepts, and epidemiologic research require a valid, reproducible, and quantitative measure describing CAP severity.

Methods: Using time series data of 1532 patients enrolled in the PROGRESS study, we compared putative measures of CAP severity for their utility as an operationalization. Read More

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http://dx.doi.org/10.1186/s13054-019-2316-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450002PMC
April 2019
2 Reads

Insertion sequences drive the emergence of a highly adapted human pathogen.

Microb Genom 2019 Apr 4. Epub 2019 Apr 4.

1​Université Grenoble Alpes, CNRS ERL5261, INSERM U1036, CEA, Laboratory Biology of Cancer and Infection, Bacterial Pathogenesis and Cellular Responses, Biosciences and Biotechnology Institute of Grenoble, 38000 Grenoble, France.

Pseudomonas aeruginosa is a highly adaptive opportunistic pathogen that can have serious health consequences in patients with lung disorders. Taxonomic outliers of P. aeruginosa of environmental origin have recently emerged as infectious for humans. Read More

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http://dx.doi.org/10.1099/mgen.0.000265DOI Listing
April 2019
5 Reads

Changes in Serotype of After the Introduction of the 13-Valent Pneumococcal Vaccine in a Homogenous Population on Jeju Island.

Infect Chemother 2019 Mar;51(1):67-72

Department of Microbiology and Immunology, Jeju National University School of Medicine, Jeju, Korea.

We compared the serotypes of between the pre-pneumococcal conjugate vaccine (PCV)13 era and post-PCV13 era among homogenous inhabitants of an isolated South Korean island. A total of 325 strains were isolated. In the pre-PCV13 era, 19A/F, 15A/F, 19B, and 23A serotypes were identified. Read More

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http://dx.doi.org/10.3947/ic.2019.51.1.67DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446012PMC
March 2019
1 Read

Complications of Stem Cell Transplantation that Affect Infections in Stem Cell Transplant Recipients, with Analogies to Patients with Hematologic Malignancies.

Infect Dis Clin North Am 2019 Mar 30. Epub 2019 Mar 30.

Section of Bone Marrow Transplant and Cellular Therapy, Division of Hematology, Oncology and Cell Therapy, Rush University Medical Center, 1725 West Harrison Street, Suite 809, Chicago, IL 60612, USA. Electronic address:

This article discusses the complications of hematopoietic stem cell transplantion (HSCT) that affect infections in HSCT recipients, with analogies to patients with hematologic malignancies. Mucositis, with mucosal barrier disruption, is common and increases the risk of gram-positive and anaerobic bacterial, and fungal infections, and can evolve to typhlitis. Engraftment syndrome; graft-versus-host disease, hepatic sinusoidal obstruction syndrome; and posterior reversible encephalopathy syndrome can affect the infectious potential either directly from organ dysfunction or indirectly from specific treatment. Read More

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http://dx.doi.org/10.1016/j.idc.2019.01.002DOI Listing
March 2019
3 Reads

Combination of clinical symptoms and blood biomarkers can improve discrimination between bacterial or viral community-acquired pneumonia in children.

BMC Pulm Med 2019 Apr 2;19(1):71. Epub 2019 Apr 2.

Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, Perth, Australia.

Background: Differentiating bacterial from viral pneumonia is important for guiding targeted management and judicious use of antibiotics. We assessed if clinical characteristics and blood inflammatory biomarkers could be used to distinguish bacterial from viral pneumonia.

Methods: Western Australian children (≤17 years) hospitalized with radiologically-confirmed community-acquired pneumonia were recruited and clinical symptoms and management data were collected. Read More

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http://dx.doi.org/10.1186/s12890-019-0835-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444754PMC

A Genomic Approach to Identify and Strains with Enhanced Competitive Fitness in the Lungs During Multi-Strain Pneumonia.

Infect Immun 2019 Apr 1. Epub 2019 Apr 1.

Department of Microbiology and Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA

Microbial competition is most often studied at the genus or species level, but interstrain competition has been less thoroughly examined. is an important pathogen in the context of hospital-acquired pneumonia, and a better understanding of strain competition in the lungs could explain why some strains of this bacterium are more frequently isolated from pneumonia patients than others. We developed a barcode-free method called "StrainSeq" to simultaneously track the abundance of ten strains in a murine pneumonia model. Read More

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http://dx.doi.org/10.1128/IAI.00871-18DOI Listing
April 2019
3 Reads

Validation of a diagnostic score model for the prediction of Legionella pneumophila pneumonia.

J Infect Chemother 2019 Mar 29. Epub 2019 Mar 29.

Development of Anti-Infective Agents, Faculty of Medical Science and Welfare, Tohoku Bunka Gakuen University, Japan.

Background: Community-acquired pneumonia (CAP) due to Legionella has a high mortality rate in patients who do not receive adequate antibiotic therapy. In a previous study, we developed a simple Legionella Score to distinguish patients with Legionella and non-Legionella pneumonia based on clinical information at diagnosis. In the present study, we validated this Legionella Score for the presumptive diagnosis of Legionella CAP. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1341321X193007
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http://dx.doi.org/10.1016/j.jiac.2019.03.009DOI Listing
March 2019
13 Reads

Quantitative microbial risk assessment of Legionella pneumophila in a drinking water supply system in Israel.

Sci Total Environ 2019 Mar 20;671:404-410. Epub 2019 Mar 20.

Department of Evolutionary and Environmental Biology, Faculty of Natural Sciences, University of Haifa, Haifa, Israel; Department of Biology and Environment, Faculty of Natural Sciences, University of Haifa, Oranim, Tivon, Israel.

Legionella pneumophila cause human infections via inhalation of contaminated water aerosols, resulting in severe pneumonia. Legionella spp. prevalence was monitored in a drinking-water distribution system (DWDS) in Northern Israel. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.03.287DOI Listing

A Case of Pulmonary Mycetoma Caused by .

Eur J Case Rep Intern Med 2019 20;6(2):001040. Epub 2019 Feb 20.

Internal Medicine Department, Hospital de Egas Moniz, Lisbon, Portugal.

Fungal infections caused by species are rare. Although most cases of human infection occur in immunocompromised patients, this species is also being increasingly recognized as a pathogen in immunocompetent individuals. and are the most common pathogens in humans. Read More

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http://dx.doi.org/10.12890/2019_001040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432827PMC
February 2019
5 Reads

Contagious caprine pleuropneumonia - a comprehensive review.

Vet Q 2019 Dec;39(1):1-25

f Animal Health Division , Central Institute for Research on Goats (CIRG) , Mathura , India.

Contagious caprine pleuropneumonia (CCPP) is a serious disease of goats, occasionally sheep and wild ruminants, caused by Mycoplasma capricolum subspecies capripneumoniae (Mccp). The disease is characterized by severe serofibrinous pleuropneumonia, very high morbidity (∼100%), and mortality (80-100%). CCPP affects goats in more than 40 countries of the world thereby posing a serious threat to goat farming around the globe. Read More

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http://dx.doi.org/10.1080/01652176.2019.1580826DOI Listing
December 2019
1 Read

Rhenium and Yttrium ions as antimicrobial agents against multidrug resistant Klebsiella pneumonia and Acinetobacter baumanii biofilms.

Lett Appl Microbiol 2019 Mar 31. Epub 2019 Mar 31.

Microbiology at Interfaces Research Group, Manchester Metropolitan University, Chester Street, Manchester, M1 5GD, UK.

Antimicrobial resistance (AMR) presents major global concerns to patient health. In this study, metal ions of Molybdenum, Rhenium, Yttrium and Thallium were tested against bacteria in planktonic and biofilm form using one strain of each of Klebsiella pneumoniae and Acinetobacter baumannii. The antimicrobial efficacy of the metal ions was evaluated against the planktonic bacterial strains using minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs), whilst the efficacy of the metal ions against biofilms was tested using a crystal violet biofilm assay. Read More

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http://dx.doi.org/10.1111/lam.13154DOI Listing
March 2019
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In Vivo Mouse Models to Study Pneumococcal Host Interaction and Invasive Pneumococcal Disease.

Methods Mol Biol 2019 ;1968:173-181

Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Bioclinicum, Stockholm, SE-17164, Sweden.

Animal models are fundamental tools to study the biology of physiological processes and disease pathogenesis. To study invasive pneumococcal disease (IPD), many models using mice in particular have been established and developed during recent years. Thanks to the advances of the research in the pneumococcal field, nowadays, there is the possibility to use defined mouse models to study each disease caused by the pneumococcus. Read More

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http://dx.doi.org/10.1007/978-1-4939-9199-0_14DOI Listing
January 2019
1 Read

Molecular characterization and analysis of Mycoplasma pneumoniae among patients of all age with community-acquired pneumonia during an epidemic in China.

Int J Infect Dis 2019 Mar 26. Epub 2019 Mar 26.

Department of Respiratory and Critical Care Medicine, Clinical Microbiology and Infectious Disease Lab, China-Japan Friendship Hospital, Beijing, China.

Background: Analysis of the molecular characteristics of isolates is very important for clinical and epidemiological study of community-acquired pneumonia (CAP) caused by M. pneumoniae.

Methods: Between 2010 and 2012, an epidemic period, M. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.03.028DOI Listing
March 2019
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Chryseobacterium Indologenes as a Novel Cause of Bacteremia in a Neonate.

J Coll Physicians Surg Pak 2019 Apr;29(4):375-378

Department of Microbiology, Combined Military Hospital Lahore Medical College and Institute of Dentistry, NUMS, Lahore, Pakistan.

Chryseobacterium indologenes is a rare human pathogen. It is an emerging species, least frequently reported from pediatric age group and known to cause pneumonia, bacteremia, and meningitis. The inherent resistant of one of the species to commonly prescribed broad-spectrum antibiotics makes it formidable challenge in the hospital settings. Read More

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http://dx.doi.org/10.29271/jcpsp.2019.04.375DOI Listing
April 2019
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The Rise of Valley Fever: Prevalence and Cost Burden of Coccidioidomycosis Infection in California.

Int J Environ Res Public Health 2019 Mar 28;16(7). Epub 2019 Mar 28.

Department of Social Sciences, Humanities and Arts, University of California, Merced, CA 95343, USA.

Coccidioidomycosis (CM) is a fungal infection endemic in the southwestern United States (US). In California, CM incidence increased more than 213% (from 6.0/100,000 (2014) to 18. Read More

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https://www.mdpi.com/1660-4601/16/7/1113
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http://dx.doi.org/10.3390/ijerph16071113DOI Listing
March 2019
3 Reads

Lower Respiratory Tract Infections in Children in a Well-vaccinated South African Birth Cohort: Spectrum of Disease and Risk Factors.

Clin Infect Dis 2019 Mar 29. Epub 2019 Mar 29.

Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital and Medical Research Council Unit on Child and Adolescent Health, University of Cape Town, Cape Town, South Africa.

Background: Childhood lower respiratory tract infections (LRTIs) cause substantial morbidity and under-5 child mortality. The epidemiology of LRTI is changing in low- and middle-income countries with expanding access to conjugate vaccines, yet there are few data on the incidence and risk factors for LRTI in these settings.

Methods: A prospective birth cohort enrolled mother-infant pairs in 2 communities near Cape Town, South Africa. Read More

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https://academic.oup.com/cid/advance-article/doi/10.1093/cid
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http://dx.doi.org/10.1093/cid/ciz017DOI Listing
March 2019
4 Reads

Cefquinome-Loaded Microsphere Formulations in Protection against Pneumonia with Klebsiella pneumonia Infection and Inflammatory Response in Rats.

Pharm Res 2019 Mar 28;36(5):74. Epub 2019 Mar 28.

College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao, 266109, China.

Purpose: This study aimed to compare in vivo activity between cefquinome (CEQ)-loaded poly lactic-co-glycolic acid (PLGA) microspheres (CEQ-PLGA-MS) and CEQ injection (CEQ-INJ) against Klebsiella pneumonia in a rat lung infection model.

Methods: Forty-eight rats were divided into control group (sham operated without infection and drug treatment), Klebsiella pneumonia model group (KPD + Saline), CEQ-PLGA-MS and CEQ-INJ therapy groups (KPD + CEQ-PLGA-MS and KPD + INJ, respectively). In the KPD + Saline group, rats were infected with Klebsiella pneumonia ATCC 10031. Read More

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http://dx.doi.org/10.1007/s11095-019-2614-7DOI Listing
March 2019
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Rapid resolution of reversible bronchiectasis after Mycoplasma pneumoniae pneumonia in an adult: A case report.

Authors:
Qi Guo Hai-Yan Li

Medicine (Baltimore) 2019 Mar;98(13):e15048

Medical Department, The Eighth Affiliated Hospital (Shenzhen Futian), Sun Yat-sen University, Shenzhen, Guangdong, China.

Rationale: Bronchiectasis results when inflammatory and infectious damage to the bronchial and bronchiolar walls leads to a vicious cycle of airway injury. On the basis of the classic characteristic, that is, permanent bronchial dilatation, bronchiectasis is generally considered irreversible in the adult population.

Patient Concerns: A 21-year-old woman presented to our hospital with a 9-day history of productive cough and fever. Read More

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http://dx.doi.org/10.1097/MD.0000000000015048DOI Listing
March 2019
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Risk factors analysis of nosocomial pneumonia in elderly patients with acute cerebral infraction.

Medicine (Baltimore) 2019 Mar;98(13):e15045

Department of Clinical laboratory, TianJin First Hospital, China.

To investigate the risk factors of nosocomial pneumonia (NP) in elderly patients with acute cerebral infarction (ACI).In this study, 324 aged 70 years and over patients with ACI who were admitted to the inpatient department of TianJin First Hospital (China) from January 2012 to February 2018 were retrospectively analyzed. The patients were divided into NP group (80 patients) and non-NP group (244 patients) according to whether NP was occurred 48 hours after hospitalization. Read More

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http://dx.doi.org/10.1097/MD.0000000000015045DOI Listing
March 2019
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Risk factors for acquisition and mortality of multidrug-resistant Acinetobacter baumannii bacteremia: A retrospective study from a Chinese hospital.

Medicine (Baltimore) 2019 Mar;98(13):e14937

Department of Respiratory Diseases, First Affiliated Hospital, School of Medicine, Zhejiang University.

Bloodstream infection caused by Acinetobacter baumannii has become a major clinical concern, especially multidrug-resistant A baumannii (MDRAB). The aim of this study was to identify the risk factors of nosocomial acquired MDRAB bacteremia and to determine the risk factors related to the mortality of patients with MDRAB bacteremia. Patients with nosocomial acquired A baumannii bacteremia were enrolled between January, 2013 and December, 2017 at the First Affiliated Hospital, School of Medicine, Zhejiang University. Read More

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http://dx.doi.org/10.1097/MD.0000000000014937DOI Listing
March 2019
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Genetics in community-acquired pneumonia.

Curr Opin Pulm Med 2019 May;25(3):323-329

Department of Sciences, University College Roosevelt, Middelburg.

Purpose Of Review: Host defense against community-acquired pneumonia depends on an intact innate and acquired immune system. This review analyses the correlation between specific defects and polymorphisms of immunity genes with susceptibility for pneumonia.

Recent Findings: Mutations in BTK, Bruton's tyrosine kinase, lead to X-linked agammaglobulinemia, a disease characterized by recurrent respiratory tract infections, including pneumonia. Read More

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http://dx.doi.org/10.1097/MCP.0000000000000580DOI Listing
May 2019
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Antibiotics susceptibility pattern of Streptococcus pneumoniae isolated from sputum cultures of human immunodeficiency virus infected patients in Yaoundé, Cameroon.

Pan Afr Med J 2018 5;31:16. Epub 2018 Oct 5.

Yaoundé Central Hospital, Cameroon.

Introduction: The susceptibility of Streptococcus pneumoniae to commonly used antibiotics is threatened by the emergence of resistance of S. pneumonia strains. So, to improve the management of lower respiratory tract infections (LRTIs) in human immunodeficiency virus infected patients, we assessed the antibiotic susceptibility of Streptococcus pneumoniae which is the most common bacterial cause of LRTIs in patients. Read More

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http://dx.doi.org/10.11604/pamj.2018.31.16.11195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430946PMC
April 2019
10 Reads

High Genetic Diversity among Isolates from Single Hospital: Nosocomial Outbreaks or Genotypic Profile Changes during Subcultures.

Malays J Med Sci 2018 Mar 27;25(2):40-49. Epub 2018 Apr 27.

Near East University, Department of Clinical Microbiology and Infections Diseases, Nicosia, Cyprus.

Background: is a non-fermentative gram-negative bacillus which is widely recognised as an important nosocomial pathogen causing pneumonia, blood-stream, wound and urinary tract infections, particularly in immunosuppressed patients. The aim of this study was to evaluate a nosocomial outbreak of by in an intensive care unit of a tertiary hospital and evaluate unexpected multiclonality.

Methods: A total of 11 isolates from respiratory cultures in intensive care unit of a 24 bed tertiary hospital obtained over a one months period and one isolate obtained from the nebuliser during environmental screening were investigated. Read More

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http://dx.doi.org/10.21315/mjms2018.25.2.5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422583PMC
March 2018
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Molecular typing of strains in Sweden, 1996-2017, and the emergence of a new P1 cytadhesin gene, Variant 2e.

J Clin Microbiol 2019 Mar 27. Epub 2019 Mar 27.

Department of Medical Sciences, Section of Clinical Microbiology and Infectious Diseases, Uppsala University, Uppsala, Sweden.

causes respiratory infections, such as community-acquired pneumonia (CAP), with epidemics recurring every 3-7 years. In 2010-2011, many countries experienced an extraordinary epidemic peak. The cause of these recurring epidemics is not understood, but decreasing herd immunity and shifts in the strains' antigenic properties have been suggested as contributing factors. Read More

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http://dx.doi.org/10.1128/JCM.00049-19DOI Listing
March 2019
3 Reads