37,429 results match your criteria Pneumonia Fungal


Chemical composition and antimicrobial activity of cuticular and internal lipids of the insect Rhynchophorus palmarum.

Arch Insect Biochem Physiol 2020 Jul 5:e21723. Epub 2020 Jul 5.

Institute of Pharmaceutical Sciences, Federal University of Alagoas, Maceió, Alagoas, Brazil.

Insect cuticle lipids are involved in various types of chemical communication between species, and reduce the penetration of insecticides, chemicals, and toxins, as well as provide protection against the attack of microorganisms, parasitic insects, and predators. Ecological studies related to the insect Rhynchophorus palmarum are well-known; however, very little is known about its resistance mechanisms, which includes its lipid composition and its importance, specifically the cuticle layer. This study aimed to characterize the cuticle and internal lipid compounds of the male and female R. Read More

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http://dx.doi.org/10.1002/arch.21723DOI Listing

Update on invasive fungal infections in the Middle Eastern and North African region.

Braz J Microbiol 2020 Jul 5. Epub 2020 Jul 5.

Laboratoire Microbiologie Santé et Environnement (LMSE), Doctoral School of Science and Technology, Faculty of Public Health, Lebanese University, Tripoli, Lebanon.

In the recent years, the epidemiology of invasive fungal infections (IFIs) has changed worldwide. This is remarkably noticed with the significant increase in high-risk populations. Although surveillance of such infections is essential, data in the Middle Eastern and North African (MENA) region remain scarce. Read More

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http://dx.doi.org/10.1007/s42770-020-00325-xDOI Listing

No SARS-CoV-2 detection in the German CAPNETZ cohort of community acquired pneumonia before COVID-19 peak in March 2020.

Infection 2020 Jul 3. Epub 2020 Jul 3.

Department of Internal Medicine II, School of Medicine, Technical University Munich, University Hospital rechts der Isar, Munich, Germany.

Purpose: The first SARS-CoV-2 cases in Europe were reported in January 2020. Recently, concern arose on unrecognized infections before this date. For a better understanding of the pandemic, we retrospectively analyzed patient samples for SARS-CoV-2 from the prospective CAPNETZ study cohort. Read More

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http://dx.doi.org/10.1007/s15010-020-01471-yDOI Listing

Pediatric Hypersensitivity Pneumonitis: Clinicopathologic Characteristics of Two Cases with Fungal Triggers.

Fetal Pediatr Pathol 2020 Jul 3:1-8. Epub 2020 Jul 3.

Department of Pathology, University of Florida College of Medicine, Gainesville, FL, USA.

Hypersensitivity pneumonitis (HP) infrequently presents in childhood. Asthma or a pneumonia-like clinical presentation may lead to diagnostic delay, especially in children. We present two cases of HP, a 6-year-old (Case 1) male and a 5-year-old (Case 2) female. Read More

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http://dx.doi.org/10.1080/15513815.2020.1786201DOI Listing

COVID-19 and the Digestive System.

Am J Gastroenterol 2020 Jul;115(7):1003-1006

Department of Gastroenterology, West China Hospital and State Key Lab of Biotherapy, Sichuan University, Chengdu, China.

The outbreak of novel coronavirus pneumonia in 2019 (Coronavirus disease 2019 [COVID-19]) is now threatening global public health. Although COVID-19 is principally defined by its respiratory symptoms, it is now clear that the virus can also affect the digestive system. In this review, we elaborate on the close relationship between COVID-19 and the digestive system, focusing on both the clinical findings and potential underlying mechanisms of COVID-19 gastrointestinal pathogenesis. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000691DOI Listing

Phylogenetic Analysis and Structural Perspectives of RNA-Dependent RNA-Polymerase Inhibition from SARs-CoV-2 with Natural Products.

Interdiscip Sci 2020 Jul 3. Epub 2020 Jul 3.

State Key Lab of Microbial Metabolism, Department of Bioinformatics and Biological Statistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China.

Most recently, an outbreak of severe pneumonia caused by the infection of SARS-CoV-2, a novel coronavirus first identified in Wuhan, China, imposes serious threats to public health. Upon infecting host cells, coronaviruses assemble a multi-subunit RNA-synthesis complex of viral non-structural proteins (nsp) responsible for the replication and transcription of the viral genome. Therefore, the role and inhibition of nsp12 are indispensable. Read More

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http://dx.doi.org/10.1007/s12539-020-00381-9DOI Listing

First report of paracoccidioidomycosis reactivation as a complication of immunosuppressive therapy for acute severe colitis in a caving enthusiast.

BMJ Case Rep 2020 Jul 2;13(7). Epub 2020 Jul 2.

Department of Gastroenterology, Weston Area Health NHS Trust, Weston-super-Mare, England, UK.

Treatment for ulcerative colitis often requires the administration of immunosuppressive therapy. Shortly after rescue therapy with infliximab for acute severe colitis, a patient who was also taking corticosteroids, azathioprine and adalimumab became rapidly unwell with atypical pneumonia, which did not respond to conventional antimicrobials. Re-examining the travel history revealed a prior caving trip to Costa Rica. Read More

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http://dx.doi.org/10.1136/bcr-2019-234125DOI Listing

Clinical characteristics of four cancer patients with SARS-CoV-2 infection in Wuhan, China.

Infect Dis Poverty 2020 Jul 2;9(1):82. Epub 2020 Jul 2.

Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Donghu road 169, Wuhan, 430071, China.

Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to the outbreak of pneumonia in Wuhan. The virus is highly infectious. Patients with cancer might be susceptible to the viral infection because of the immunosuppressive state cause by therapies on tumors. Read More

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http://dx.doi.org/10.1186/s40249-020-00707-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330531PMC

First report of pneumonia and septic shock caused by in Vietnam.

New Microbes New Infect 2020 Jul 23;36:100698. Epub 2020 May 23.

108 Military Central Hospital, Ha Noi, Vietnam.

is rarely known to cause infections in humans. We report the first case of pneumonia and septic shock caused by in a 38-year-old man in Vietnam. may be an emerging infectious agent in humans. Read More

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http://dx.doi.org/10.1016/j.nmni.2020.100698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322337PMC

Determination of Antimicrobial Prescribing Practices in an Integrated Health System Emergency Department.

Kans J Med 2020 25;13:131-133. Epub 2020 Jun 25.

University of Kansas School of Medicine, Kansas City, KS.

Introduction: Antibiotic stewardship utilizes interprofessional collaborative practices, including professionals from medicine, pharmacy, nursing, social services, and clinical laboratory science, to identify potential problems proactively. A tertiary care integrated health system's Emergency Department (ED) aimed to identify antimicrobials prescribed to the outpatient community as part of a proactive antimicrobial stewardship project.

Methods: A pilot, prospective, snapshot of a tertiary community hospital's outpatient antimicrobial prescribing habits was conducted. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324061PMC

Detection of several carbapenems resistant and virulence genes in classical and hyper-virulent strains of Klebsiella pneumoniae isolated from hospitalized neonates and adults in Khartoum.

BMC Res Notes 2020 Jul 1;13(1):312. Epub 2020 Jul 1.

Biochemistry Department, Faculty of Sciences, King Abdulaziz University, Jeddah, 21452, Saudi Arabia.

Objective: Klebsiella pneumoniae (K. pneumoniae) involves both community-acquired and nosocomial infections. It is responsible for a wide variety of infections, including infections of the urinary tract, pneumonia, bacteremia, meningitis, wound infection and purulent abscesses. Read More

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http://dx.doi.org/10.1186/s13104-020-05157-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328261PMC

Association of Nonsteroidal Anti-inflammatory Drug Use and Adverse Outcomes Among Patients Hospitalized With Influenza.

JAMA Netw Open 2020 Jul 1;3(7):e2013880. Epub 2020 Jul 1.

Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark.

Importance: During the ongoing coronavirus disease 2019 pandemic, case reports have suggested that the use of nonsteroidal anti-inflammatory drugs (NSAIDs) may lead to adverse outcomes.

Objective: To study the association of NSAID use with adverse outcomes in patients hospitalized with influenza or influenza pneumonia.

Design, Setting, And Participants: This cohort study used propensity score matching among 7747 individuals aged 40 years or older who were hospitalized with influenza, confirmed by polymerase chain reaction or antigen testing, between 2010 and 2018. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2020.13880DOI Listing

Pneumocystis Jirovecii Pneumonia and SARS-CoV-2 Co-Infection in newly diagnosed HIV-1 infection.

Clin Infect Dis 2020 Jul 1. Epub 2020 Jul 1.

Department of Pneumology, Allergology and Critical Care Medicine, Saarland University, Homburg/Saar, Germany.

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http://dx.doi.org/10.1093/cid/ciaa906DOI Listing

The emergence of novel coronavirus disease (COVID-19) in Bangladesh: Present status, challenges, and future management.

J Adv Vet Anim Res 2020 Jun 22;7(2):198-208. Epub 2020 Mar 22.

Department of Plant Pathology, Bangabandhu Sheikh Mujibur Rahman Agricultural University, Gazipur, Bangladesh.

Immediate after the official declaration of COVID-19 in Bangladesh on 8 March 2020, it has created public panic which results in price plummeting of the capital market and price hike of many essential commodities. Worldwide, the outbreak of COVID-19 has declared a pandemic. In response, the Government of Bangladesh has initiated some strict measures such as stopping the entry of passengers from Europe, stopping on-arrival visas and self-quarantine for 2 weeks for all passengers return from abroad. Read More

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http://dx.doi.org/10.5455/javar.2020.g410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320814PMC

Etiology of Community-Acquired Pneumonia Requiring Hospital Admission in Adults with and Without Cancers: A Single-Center Retrospective Study in China.

Infect Drug Resist 2020 8;13:1607-1617. Epub 2020 Jun 8.

Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Air Force Medical University, Xi'an, People's Republic of China.

Background: The etiology and distribution of community-acquired pneumonia (CAP) vary periodically and geographically. The clinical evaluation of CAP among patients with cancers remains unknown.

Patients And Methods: This retrospective hospital-based study on adult CAP was conducted in Tang Du Hospital, China, from September 2018 to August 2019. Read More

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http://dx.doi.org/10.2147/IDR.S251564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294101PMC

Endoribonuclease YbeY Is Essential for RNA Processing and Virulence in Pseudomonas aeruginosa.

mBio 2020 Jun 30;11(3). Epub 2020 Jun 30.

State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin, China

Posttranscriptional regulation plays an essential role in the quick adaptation of pathogenic bacteria to host environments, and RNases play key roles in this process by modifying small RNAs and mRNAs. We find that the endonuclease YbeY is required for rRNA processing and the bacterial virulence in a murine acute pneumonia model. Transcriptomic analyses reveal that knocking out the gene results in downregulation of oxidative stress response genes, including the catalase genes and Consistently, the mutant is more susceptible to HO and neutrophil-mediated killing. Read More

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http://dx.doi.org/10.1128/mBio.00659-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327168PMC

COVID-19 autopsy in people who died in community settings: the first series.

J Clin Pathol 2020 Jun 30. Epub 2020 Jun 30.

Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK

Here, we report the pathological findings of nine complete autopsies of individuals who died in community settings in the UK, three of which were positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), three tested negative for SARS-CoV-2 but are likely false negatives, and three died of other respiratory infections. Autopsy revealed firm, consolidated lungs or lobar pneumonia. Histology of the lungs showed changes of diffuse alveolar damage with fibrin membrane formation, thickened alveolar walls and interstitium with lymphocytic infiltrate, and type 2 pneumocyte hyperplasia with shedding into the alveolar space. Read More

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http://dx.doi.org/10.1136/jclinpath-2020-206710DOI Listing

Bacterial and fungal coinfection among hospitalised patients with COVID-19: A retrospective cohort study in a UK secondary care setting.

Clin Microbiol Infect 2020 Jun 27. Epub 2020 Jun 27.

Chelsea and Westminster NHS Foundation Trust, 369 Fulham Road, London, SW10 9NH. UK; North West London Pathology, Imperial College Healthcare NHS Trust, Fulham Palace Road. London. W6 8RF. UK; National Institute for Health Research Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Imperial College London, Hammersmith Campus, Du Cane Road, London. W12 0NN. UK.

Objectives: We investigate the incidence of bacterial and fungal co-infection of hospitalised patients with confirmed SARS-CoV-2 in this retrospective observational study across two London hospitals during the first UK wave of COVID-19.

Methods: A retrospective case-series of hospitalised patients with confirmed SARS-CoV-2 by PCR was analysed across two acute NHS hospitals (February 20-April 20; each isolate reviewed independently in parallel). This was contrasted to a control group of influenza positive patients admitted during 2019/20 flu season. Read More

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http://dx.doi.org/10.1016/j.cmi.2020.06.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320692PMC

Methylprednisolone added to tocilizumab reduces mortality in SARS-CoV-2 pneumonia: An observational study.

J Intern Med 2020 Jun 30. Epub 2020 Jun 30.

Infectious Diseases Department, Consorci Hospital General Universitari, València, Spain.

Although there are few randomized controlled trials (RCTs) evaluating the efficacy of drugs to treat COVID-19, different molecules have been used empirically and with great interest in those intended to control the excessive inflammatory response produced by SARS-CoV-2. By blocking the IL-6 receptor, tocilizumab has a role in controlling the inflammatory response. Clinical improvement of respiratory parameters and hospital stay have been described in small series in a series of patients without a control group [1]. Read More

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http://dx.doi.org/10.1111/joim.13145DOI Listing

In-Silico Analysis and Protective Efficacy of the PcrV Recombinant Vaccine against Pseudomonas Aeruginosa in the Burned and PA-Infected BALB/c Mouse Model.

Iran J Immunol 2020 Jun;17(2):121-136

Department of Microbiology, Karaj Branch, Islamic Azad University, Karaj, Iran.

Background: Pseudomonas aeruginosa is considered as the most severe cause of infections in burn patients and pneumonia infections.

Objective: To study the protective effects of recombinant protein vaccine harboring the PcrV of P. aeruginosa in the mouse model of burn and respiratory infections. Read More

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http://dx.doi.org/10.22034/iji.2020.85590.1718DOI Listing

A Structure-Function-Inhibition Analysis of the Type III Secretion Needle Protein PscF.

J Bacteriol 2020 Jun 29. Epub 2020 Jun 29.

Microbiotix, Inc., Worcester, MA, USA 01605.

The type III secretion system (T3SS) needle comprised of multiple PscF subunits is essential for the translocation of effector toxins into human cells, facilitating the establishment and dissemination of infection. Mutations in the gene provide resistance to the phenoxyacetamide (PhA) series of T3SS inhibitory chemical probes. To better understand PscF functions and interactions with PhA, alleles of with 71 single mutations altering 49 of the 85 residues of the encoded protein were evaluated for their effects on T3SS phenotypes. Read More

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http://dx.doi.org/10.1128/JB.00055-20DOI Listing

S1-Domain RNA-Binding Protein (CvfD) Is a New Post-Transcriptional Regulator That Mediates Cold Sensitivity, Phosphate Transport, and Virulence in D39.

J Bacteriol 2020 Jun 29. Epub 2020 Jun 29.

Department of Biology, Indiana University Bloomington, Jordan Hall; 1001 East Third Street; Bloomington, Indiana 47405

Post-transcriptional gene regulation often involves RNA-binding proteins that modulate mRNA translation and/or stability either directly through protein-RNA interactions or indirectly by facilitating the annealing of small regulatory RNAs (sRNAs). The human pathogen D39 (pneumococcus) does not encode homologs to RNA-binding proteins known to be involved in promoting sRNA stability and function, such as Hfq or ProQ, even though it contains genes for at least 112 sRNAs. However, the pneumococcal genome contains genes for other RNA-binding proteins, including at least six S1-domain proteins; ribosomal protein S1 (), polynucleotide phosphorylase (), RNase R (), and three proteins of unknown functions. Read More

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http://dx.doi.org/10.1128/JB.00245-20DOI Listing

Dysregulation of angiopoietin-Tie-2 axis in ugandan children hospitalized with pneumonia.

Cytokine 2020 Jun 26;133:155175. Epub 2020 Jun 26.

Department of Pediatrics, University of Alberta, Canada; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Canada; School of Public Health, University of Alberta, Edmonton, Canada; Distinguished Researcher, Stollery Science Lab, Canada; Member, Women and Children's Health Research Institute, Canada. Electronic address:

Objective: Pneumonia is the leading cause of death in children under 5, with the highest burden in resource-limited countries. Endothelial activation occurs in pneumonia and can be assessed using quantitative levels of biomarkers angiopoietin (Ang)-1 and Ang-2. We examined admission levels of Ang-1 and Ang-2 in pediatric pneumonia and their association with disease severity and outcome. Read More

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http://dx.doi.org/10.1016/j.cyto.2020.155175DOI Listing

Green synthesis, characterization, antimicrobial and cytotoxic effect of silver nanoparticles using arabinoxylan isolated from Kalmegh.

Int J Biol Macromol 2020 Jun 26. Epub 2020 Jun 26.

Department of Chemistry, Panskura Banamali College, Panskura, Purba Midnapore Pin-721152, West Bengal, India. Electronic address:

A green synthesis of silver nanoparticles was synthesized by AgNO with arabinoxylan, isolated from green stem of Andrographis paniculata (Kalmegh). The synthesized Ag NPs-arabinoxylan conjugates were characterized by UV-vis spectroscopy, FE-SEM, TEM, XRD, TGA, EDX, and Zeta potential experiments. The Ag NPs formation was established by the surface plasmon resonance band ~410. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2020.06.215DOI Listing

Drug treatment of coronavirus disease 2019 (COVID-19) in China.

Eur J Pharmacol 2020 Jun 26:173326. Epub 2020 Jun 26.

National Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University, Chongqing, 400038, PR China. Electronic address:

Since December 2019, the coronavirus disease 2019 (COVID-19) caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has spread throughout China as well as other countries. More than 8,700,000 confirmed COVID-19 cases have been recorded worldwide so far, with much more cases popping up overseas than those inside. As the initial epicenter in the world, China has been combating the epidemic for a relatively longer period and accumulated valuable experience in prevention and control of COVID-19. Read More

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http://dx.doi.org/10.1016/j.ejphar.2020.173326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319927PMC

Alterations in Fecal Fungal Microbiome of Patients With COVID-19 During Time of Hospitalization until Discharge.

Gastroenterology 2020 Jun 24. Epub 2020 Jun 24.

Center for Gut Microbiota Research, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China; State Key Laboratory for digestive disease, Institute of Digestive Disease, Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Shatin, Hong Kong, China; Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China. Electronic address:

Backgroud & Aims: SARS-CoV-2 infects intestinal cells, and might affect the intestinal microbiota. We investigated changes in the fecal fungal microbiomes (mycobiome) of patients with SARS-CoV-2 infection during hospitalization and upon recovery.

Methods: We performed deep shotgun metagenomic sequencing analysis of fecal samples from 30 patients with COVID-19 in Hong Kong, from February 5 through May 12, 2020. Read More

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http://dx.doi.org/10.1053/j.gastro.2020.06.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318920PMC

[Surfactant proteins A and D: role in the pathogenesis of community-acquired pneumonia and possible predictive perspectives].

Ter Arkh 2020 Apr 27;92(3):109-115. Epub 2020 Apr 27.

Research Institute of Therapy and Preventive Medicine - branch of the Federal Research Center Institute of Cytology and Genetics.

Community-acquired pneumonia is one of the most common infectious diseases and remains one of the leading causes of death in this group of diseases. Studies of community-acquired pneumonia are extremely relevant for modern clinical practice. One of the important role in the pathogenesis of bacterial, viral, fungal invasion in the system of a human lung system belongs to the pulmonary surfactant, in particular, its proteins SP-A and SP-D. Read More

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http://dx.doi.org/10.26442/00403660.2020.03.000275DOI Listing

[Etiology of severe community - acquired pneumonia in adults: results of the first Russian multicenter study].

Ter Arkh 2020 Jan 15;92(1):36-42. Epub 2020 Jan 15.

M.K. Ammosov Federal North-Eastern University.

Aim: to study the etiology of severe community - acquired pneumonia (SCAP) in adults in Russian Federation. SCAP is distinguished by high mortality and socio - economic burden. Both etiology and antimicrobial resistance are essential for appropriate antibiotic choice. Read More

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http://dx.doi.org/10.26442/00403660.2020.01.000491DOI Listing
January 2020

New intrigant possibility for prevention of coronavirus pneumonitis: natural purified polyphenols.

Oral Dis 2020 Jun 29. Epub 2020 Jun 29.

Microbiology Ca' Foscari University, Venice, Italy.

COVID-19 is an infectious disease characterized by several important systemic problems such as severe pneumonia. One of mechanisms responsible of these systemic problems is the release of pro-inflammatory cytokines, such as interleukin (IL)-1beta and IL-6(Conti et al., 2020). Read More

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http://dx.doi.org/10.1111/odi.13518DOI Listing

Hospital care in Departments defined as COVID-free: A proposal for a safe hospitalization protecting healthcare professionals and patients not affected by COVID-19.

Arch Ital Urol Androl 2020 Apr 24;92(2). Epub 2020 Apr 24.

Musumeci GECAS Clinic, Gravina di Catania, Catania.

The COVID-19 pandemic influenced the normal course of clinical practice leading to significant delays in the delivery of healthcare services for patients non affected by COVID-19. In the near future, it will be crucial to identify facilities capable of providing health care in compliance with the safety of healthcare professionals, administrative staff and patients. All the staff involved in the project of a Covid-free hospital should be subjected to a diagnostic swab for COVID-19 before the beginning of healthcare activity and then periodically in order to avoid the risk of contamination of patients during the process of care. Read More

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http://dx.doi.org/10.4081/aiua.2020.2.67DOI Listing

In Vitro Activity of Ceftazidime/Avibactam Alone and in Combination With Fosfomycin and Carbapenems Against KPC-producing Klebsiella Pneumoniae.

New Microbiol 2020 Jun 29;43(3). Epub 2020 Jun 29.

Section of Microbiology, Interdisciplinary Department of Medicine (DIM), School of Medicine, University of Bari, Italy.

KPC-producing Klebsiella pneumonia (KPC-Kp) represents a major therapeutic challenge in critically ill patients. Ceftazidime-avibactam (CAZ-AVI) is a new effective drug against KPC-Kp but, due to emerging resistant strains during monotherapy, the association with a second antibiotic has been advocated. Therefore, intravenous fosfomycin may be a possible choice for combination therapy. Read More

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Detection of Extended-Spectrum -Lactamases (ESBL) Producing Enterobacteriaceae from Fish Trapped in the Lagoon Area of Bizerte, Tunisia.

Biomed Res Int 2020 9;2020:7132812. Epub 2020 Jun 9.

Laboratory of Epidemiology and Veterinary Microbiology, Group of Bacteriology and Biotechnology Development, Institute Pasteur of Tunis, University of Tunis El Manar, Tunisia.

Extended-spectrum -lactamase and their molecular mechanism in were analyzed in 126 fish samples of 9 various wild species, living in the lagoon of Bizerte in Tunisia. Fifty-nine (59) Gram-negative strains were isolated and identified as ( = 24), ( = 21), ( = 8), and ( = 6). Forty-seven ESBL producers were identified using the synergic test. Read More

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http://dx.doi.org/10.1155/2020/7132812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303757PMC

Economic evaluation alongside the Probiotics to Prevent Severe Pneumonia and Endotracheal Colonization Trial (E-PROSPECT): study protocol.

BMJ Open 2020 Jun 28;10(6):e036047. Epub 2020 Jun 28.

Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.

Introduction: Ventilator-associated pneumonia (VAP) is a common healthcare-associated infection in the intensive care unit (ICU). Probiotics are defined as live microorganisms that may confer health benefits when ingested. Prior randomised trials suggest that probiotics may prevent infections such as VAP and -associated diarrhoea (CDAD). Read More

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http://dx.doi.org/10.1136/bmjopen-2019-036047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322334PMC

Influenza and respiratory syncytial virus infections in the oldest-old continent.

Eur J Clin Microbiol Infect Dis 2020 Jun 27. Epub 2020 Jun 27.

Microbiology and Virology Unit, University Hospital Città della Salute e della Scienza di Torino, Turin, Italy.

SARS-CoV-2 dramatically revealed the sudden impact of respiratory viruses in our lives. Influenza and respiratory syncytial virus (RSV) infections are associated with high rates of morbidity, mortality, and an important burden on healthcare systems worldwide, especially in elderly patients. The aim of this study was to identify severity predictors in the oldest-old admitted with influenza and/or RSV infections. Read More

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http://dx.doi.org/10.1007/s10096-020-03959-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320245PMC

Effects of 1, 25-dihydroxy vitamin D3 on clinical symptoms, pro-inflammatory and inflammatory cytokines in calves with experimental pneumonia.

Res Vet Sci 2020 May 17;132:186-193. Epub 2020 May 17.

Department of Microbiology, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran.

1, 25-dihydroxycholecalciferol is recognized as a potent immune-modulator which can fight against the pathogens via the activation of vitamin D3 receptors (VDRs), as well as stimulating various cytokines in infectious diseases. In the present study, because of the vitamin D3 has an appropriate immunomodulatory, the effects of this vitamin on the levels of pre-inflammatory and anti-inflammatory cytokines have been investigated in calves with experimental pasteurellosis. This study was experimentally carried out on 10 Holstein crossbred male calves (2-4 months) that were divided into two groups. Read More

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http://dx.doi.org/10.1016/j.rvsc.2020.04.018DOI Listing

Favorable COVID-19 course despite significant comorbidities in a ruxolitinib-treated patient with primary myelofibrosis.

Eur J Haematol 2020 Jun 27. Epub 2020 Jun 27.

Department of Pneumology and Intensive Care Medicine, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.

COVID-19 carries a high risk of severe disease course, particularly in patients with comorbidities. Therapy of severe COVID-19 infection has relied on supportive intensive care measures. More specific approaches including drugs that limit the detrimental "cytokine storm", such as Janus-activated kinase (JAK) inhibitors, are being discussed. Read More

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http://dx.doi.org/10.1111/ejh.13480DOI Listing

Elevated body-mass index is associated with an increased risk of infectious disease admissions and mortality: a mendelian randomization study.

Clin Microbiol Infect 2020 Jun 24. Epub 2020 Jun 24.

Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, Québec, Canada; Department of Human Genetics, McGill University, Montréal, Québec, Canada; Department of Twin Research, King's College London, London, UK. Electronic address:

Objective: The effect of body-mass index (BMI) on the risk of infectious diseases admissions and mortality is unclear and is difficult to study given risks of confounding variables.

Methods: We used genome-wide association studies (GWAS) with mendelian randomisation (MR) to obtain causal inference of BMI on the following infectious diseases outcomes: hospital admissions for pneumonia, sepsis, urinary tract infections, skin and soft tissue infections (SSTI) or all-cause infections. For patients with pneumonia and sepsis, we also analyzed their 28-day and 90-day mortality. Read More

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http://dx.doi.org/10.1016/j.cmi.2020.06.014DOI Listing

Ventilator-associated pneumonia in neonates: the role of point of care lung ultrasound.

Eur J Pediatr 2020 Jun 26. Epub 2020 Jun 26.

Neonatal Intensive Care Unit, Evelina London Children's Hospital, Guy's and St Thomas' NHS Foundation Trust, St Thomas' Hospital, North Wing 6th floor, Westminster Bridge Road, London, SE1 0EH, UK.

No consensus exists regarding the definition of ventilator-associated pneumonia (VAP) in neonates and reliability of chest X-ray (CXR) is low. Lung ultrasound (LU) is a potential alternative diagnostic tool. The aim was to define characteristics of VAP in our patient population and propose a multiparameter score, incorporating LU, for VAP diagnosis. Read More

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http://dx.doi.org/10.1007/s00431-020-03710-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317892PMC

The ORF6, ORF8 and nucleocapsid proteins of SARS-CoV-2 inhibit type I interferon signaling pathway.

Virus Res 2020 Jun 23;286:198074. Epub 2020 Jun 23.

Institute of Pathogen Biology and Immunology, College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan University, Changsha 410082, Hunan, China. Electronic address:

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel human coronavirus causing the pandemic of severe pneumonia (Coronavirus Disease 2019, COVID-19). SARS-CoV-2 is highly pathogenic in human, having posed immeasurable public health challenges to the world. Innate immune response is critical for the host defense against viral infection and the dysregulation of the host innate immune responses probably aggravates SARS-CoV-2 infection, contributing to the high morbidity and lethality of COVID-19. Read More

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http://dx.doi.org/10.1016/j.virusres.2020.198074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309931PMC

Postmortem swabs in the Sars-CoV-2 Pandemic: Report on 12 complete clinical autopsy cases.

Arch Pathol Lab Med 2020 Jun 26. Epub 2020 Jun 26.

Department of Woman and Child Health and Public Health, Area of Pathology, Catholic University of Sacred Heart, Fondazione Policlinico Universitario A. Gemelli IRCCS, U.O.S.D. Coordinamento attività di Settorato; Rome, Italy (Dr. Dell'Aquila, Mr. Stigliano, Dr. Carbone, Dr. Arena); Department of Basic Biotechnological Sciences, Intensivological and Perioperative Clinics, Fondazione Policlinico A. Gemelli IRCCS, Catholic University of Sacred Heart, Rome, Italy (Dr. Cattani); Department of laboratory and infectivological sciences, Fondazione Policlinico A. Gemelli IRCCS, Catholic University of Sacred Heart, Rome, Italy (Dr. Fantoni); Department of Safety and Bioethics, Section of Infectious Diseases, Catholic University of Sacred Heart; Columbus Covid 2 Hospital, Fondazione Policlinico A Gemelli IRCCS, Roma, Italy Università Cattolica S. Cuore, (Dr. Marchetti); Institute of Legal Medicine and Department of Surgical and Medical Sciences at the University "Magna Graecia" of Catanzaro, Italy (Dr. Aquila); Department of Safety and Bioethics, Section of Legal Medicine, Fondazione Policlinico A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy (Dr. Oliva).

Clinical autopsies have historically provided a fundamental contribution in the definition of the clinico-pathological basis of infectious diseases. Even though we are witnessing the decline of the clinical autopsy, its importance remains unchanged as it is the most exhaustive way to investigate diseases. The identification of the virus in postmortem tissues is a fundamental step in the definition of its clinical features. Read More

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http://dx.doi.org/10.5858/arpa.2020-0362-SADOI Listing
June 2020
2.838 Impact Factor

Rhabdomyolysis as an initial presentation in a patient diagnosed with COVID-19.

BMJ Case Rep 2020 Jun 24;13(6). Epub 2020 Jun 24.

Pulmonary Medicine, Centro Medico ABC, Mexico City, Mexico.

The presence of rhabdomyolysis secondary to multiple infections has been reported, predominantly viral, but also bacterial and fungal. It is well known that COVID-19 can present a wide variety of complications during the course of infection; however, the presence of rhabdomyolysis as an initial condition has not been reported so far. We report a case of rhabdomyolysis as an initial presentation in a patient diagnosed with SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) infection. Read More

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http://dx.doi.org/10.1136/bcr-2020-236719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319710PMC

Clinical spectrum, etiology and outcome of infectious disease emergencies in adult diabetic patients in northern India.

Diabetes Metab Syndr 2020 Jun 12;14(5):921-925. Epub 2020 Jun 12.

Department of Medical Microbiology, PGIMER, Chandigarh, India. Electronic address:

Background And Aims: The patients with diabetes mellitus (DM) have an increased incidence of both common and unusual infections. Despite an increasing prevalence of DM in India, local data on the epidemiology and clinical spectrum of associated infections are lacking. We aimed to investigate the spectrum, etiology, and outcome of infectious disorders in adult patients with DM admitted in a medical emergency. Read More

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http://dx.doi.org/10.1016/j.dsx.2020.06.004DOI Listing

COVID-19 associated pulmonary aspergillosis (CAPA) in patients admitted with severe COVID-19 pneumonia: An observational study from Pakistan.

Mycoses 2020 Jun 25. Epub 2020 Jun 25.

Department of Pathology and Laboratory Medicine, Aga Khan University Karachi, Karachi, Pakistan.

Background: Invasive aspergillosis is a well-known complication of severe influenza pneumonia with acute respiratory distress syndrome (ARDS). However, recent studies are reporting emergence of aspergillosis in severe COVID-19 pneumonia, named as COVID-19 associated aspergillosis (CAPA).

Methods: A retrospective observational study was conducted in patients with severe COVID-19 pneumonia from February 2020- April 2020. Read More

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http://dx.doi.org/10.1111/myc.13135DOI Listing

UNIVERSAL MASKING DURING COVID-19 PANDEMIC - CURRENT EVIDENCE AND CONTROVERSIES.

Rev Invest Clin 2020 ;72(3):144-150

Metabolic Diseases Research Unit, Nutrition Directorate, and Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.

The emergence of coronavirus disease 19 pandemic and novel research on the high transmissibility of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has raised controversies over the use of face masks to prevent community transmission. Specific regulations need to be fulfilled to use a face mask as part of the personal protective equipment and high quality of evidence supporting its use to prevent respiratory viral infections, including SARS-CoV-2, is lacking. However, its widespread use is becoming a standard practice in some countries and discrepancies between health authorities on their policy have led to controversy. Read More

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http://dx.doi.org/10.24875/RIC.20000196DOI Listing

Prevalence of SARS-CoV-2 specific neutralising antibodies in blood donors from the Lodi Red Zone in Lombardy, Italy, as at 06 April 2020.

Euro Surveill 2020 06;25(24)

Department of Clinical Surgical Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.

We evaluated SARS-CoV-2 RNA and neutralising antibodies in blood donors (BD) residing in the Lodi Red Zone, Italy. Of 390 BDs recruited after 20 February 2020 - when the first COVID-19 case in Lombardy was identified, 91 (23%) aged 19-70 years were antibody positive. Viral RNA was detected in an additional 17 (4. Read More

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http://dx.doi.org/10.2807/1560-7917.ES.2020.25.24.2001031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315724PMC

Multicentre comparison of quantitative PCR-based assays to detect SARS-CoV-2, Germany, March 2020.

Euro Surveill 2020 06;25(24)

German Center for Infection Research, Partner Site Munich and Associated Partner Site Charité, Berlin and Associated Partner Site Frankfurt, Germany.

Containment strategies and clinical management of coronavirus disease (COVID-19) patients during the current pandemic depend on reliable diagnostic PCR assays for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we compare 11 different RT-PCR test systems used in seven diagnostic laboratories in Germany in March 2020. While most assays performed well, we identified detection problems in a commonly used assay that may have resulted in false-negative test results during the first weeks of the pandemic. Read More

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http://dx.doi.org/10.2807/1560-7917.ES.2020.25.24.2001057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315722PMC

Challenges to testing COVID-19 in conflict zones: Yemen as an example.

J Glob Health 2020 Jun;10(1):010375

Oral Microbiome Research Laboratory, Department of Oral Health Sciences, Kornberg School of Dentistry, Temple University, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.7189/jogh.10.010375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307803PMC

Molecular Insights Into SARS COV-2 Interaction With Cardiovascular Disease: Role of RAAS and MAPK Signaling.

Front Pharmacol 2020 3;11:836. Epub 2020 Jun 3.

Department of Pharmacology and Toxicology, American University of Beirut, Beirut, Lebanon.

In December 2019, reports of viral pneumonia came out of Wuhan city in Hubei province in China. In early 2020, the causative agent was identified as a novel coronavirus (CoV) sharing some sequence similarity with SARS-CoV that caused the severe acute respiratory syndrome outbreak in 2002. The new virus, named SARS-CoV-2, is highly contagious and spread rapidly across the globe causing a pandemic of what became known as coronavirus infectious disease 2019 (COVID-19). Read More

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http://dx.doi.org/10.3389/fphar.2020.00836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283382PMC

Streptococcus suis in Swedish grower pigs: occurrence, serotypes, and antimicrobial susceptibility.

Acta Vet Scand 2020 Jun 24;62(1):36. Epub 2020 Jun 24.

Department of Clinical Sciences, Swedish University of Agricultural Sciences (SLU), Box 7054, 750 07, Uppsala, Sweden.

Background: Streptococcus suis is a major cause of meningitis, arthritis, and pneumonia in pigs worldwide, and an emerging pathogen in humans. In Sweden, S. suis has previously received little attention but has in recent years become increasingly recognized as affecting the pig production. Read More

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http://dx.doi.org/10.1186/s13028-020-00533-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315512PMC