34,492 results match your criteria Pneumonia Fungal


An Acinetobacter baumannii, Zinc-Regulated Peptidase Maintains Cell Wall Integrity during Immune-Mediated Nutrient Sequestration.

Cell Rep 2019 Feb;26(8):2009-2018.e6

Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address:

Acinetobacter baumannii is an important nosocomial pathogen capable of causing wound infections, pneumonia, and bacteremia. During infection, A. baumannii must acquire Zn to survive and colonize the host. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.01.089DOI Listing
February 2019

Cystatin 9 and C modulates serum biomarkers associated with inflammation and provides prophylactic as well as long-term protection against multi-drug resistant .

Antimicrob Agents Chemother 2019 Feb 19. Epub 2019 Feb 19.

Departments of Microbiology and Immunology, and Pediatrics, University of Texas Medical Branch, 301 University Blvd., Galveston, Texas 77555-1070, USA

We have identified recombinant human cystatin 9 (rCST9) and C (rCSTC) as a combination, immunotherapeutic treatment against multi-drug resistant (MDR) New Delhi metallo-beta-lactamase-1 (NDM-1) producing (). We evaluated the lasting protection of rCST9/rCSTC treatment against MDR NDM-1 pneumonia. Results showed that rCST9/rCSTC treatment modulated endogenous serum biomarkers, cystatin 9 and C and amyloid A, associated with poor patient outcomes and provided prophylactic and long-term protection in a murine model of pneumonia. Read More

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http://dx.doi.org/10.1128/AAC.02519-18DOI Listing
February 2019

CD11b Regulates Fungal Outgrowth but Not Neutrophil Recruitment in a Mouse Model of Invasive Pulmonary Aspergillosis.

Front Immunol 2019 4;10:123. Epub 2019 Feb 4.

Department of Dermatology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.

ß2 integrin receptors consist of an alpha subunit (CD11a-CD11d) and CD18 as the common beta subunit, and are differentially expressed by leukocytes. ß2 integrins are required for cell-cell interaction, transendothelial migration, uptake of opsonized pathogens, and cell signaling processes. Functional loss of CD18-termed leukocyte-adhesion deficiency type 1 (LAD1)-results in an immunocompromised state characterized by frequent occurrence of severe infections. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369709PMC
February 2019

Description of Clinical Characteristics of VAP Patients in MIMIC Database.

Front Pharmacol 2019 4;10:62. Epub 2019 Feb 4.

Clinical Research Center, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Ventilator-associated pneumonia (VAP) is a common and serious nosocomial infection of intensive-care units (ICUs). Accurate, timely diagnosis enables early VAP patients to receive appropriate therapies and reduce the occurrence of complication. However, so far clinical datas regarding the epidemiology and mortality of VAP are still limited. Read More

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http://dx.doi.org/10.3389/fphar.2019.00062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369200PMC
February 2019

Help, hinder, hide and harm: what can we learn from the interactions between and during respiratory infections?

Thorax 2019 Feb 18. Epub 2019 Feb 18.

Departments of Pediatrics and Microbiology, University of Washington, Seattle, Washington, USA.

Recent studies of human respiratory secretions using culture-independent techniques have found a surprisingly diverse array of microbes. Interactions among these community members can profoundly impact microbial survival, persistence and antibiotic susceptibility and, consequently, disease progression. Studies of polymicrobial interactions in the human microbiota have shown that the taxonomic and structural compositions, and resulting behaviours, of microbial communities differ substantially from those of the individual constituent species and in ways of clinical importance. Read More

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http://dx.doi.org/10.1136/thoraxjnl-2018-212616DOI Listing
February 2019

Acute Respiratory Failure in Renal Transplant Recipients: A Single Center Experience.

Exp Clin Transplant 2019 Jan;17(Suppl 1):172-174

From the Pulmonary Medicine, Baskent University, Adana, Turkey.

Objectives: We evaluated the frequency and cause of acute respiratory failure in renal transplant recipients.

Materials And Methods: Our single-center retrospective observational study included consecutive renal transplant recipients who were admitted to an intensive care unit for acute respiratory failure between 2011 and 2017. Acute respiratory failure was defined as oxygen saturation < 92% or partial pressure of oxygen in arterial blood < 60 mm Hg on room air and/or requirement of noninvasive or invasive mechanical ventilation. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.P49DOI Listing
January 2019

Effect of different solvent extracted samples from the leaves and fruits of Datura stramonium on the growth of bacteria and fungi.

Pak J Pharm Sci 2019 Jan;32(1):177-184

Department of Agronomy, The University of Agriculture, Peshawar, KPK, Pakistan.

Different solvent extracted samples from the leaves and fruits tissues of D. stramonium were tested against five pathogenic microorganisms by disc diffusion susceptibility method using 1, 2 and 3mg disc concentrations. Methanol and chloroform extracted fractions from both leaves and fruits measured good growth inhibition of all the tested microorganisms at all concentrations. Read More

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January 2019

[Experience of application of the PCR for identification of the causative agent of community acquired pneumonia in the military.]

Klin Lab Diagn 2018 ;63(10):641-645

«1586 Military Clinical Hospital» of the Ministry of Defense of the Russian Federation, 603105, Nizhniy Novgorod, Russian Federation.

Samples of sputum, blood, bronchoalveolar lavage, swabs from the oropharynx from 255 military personnel undergoing in-patient treatment with an x-ray confirmed diagnosis of community-acquired pneumonia (CAP) were examined by polymerase chain reaction (PCR). The comparison group was included 270 healthy recruits. The detection of S. Read More

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http://dx.doi.org/10.18821/0869-2084-2018-63-10-641-645DOI Listing
January 2018
6 Reads

Rare Earth Element (REE) Nd Doped CeO₂ Nanoparticles Using Leaf Extract: Structural, Optical and Antimicrobial Activity.

J Nanosci Nanotechnol 2019 Jul;19(7):3964-3970

P.G and Research Department of Chemistry, A. Veeriya Vandayar Memorial Sri Pushpam College, Poondi, Thanjavur 613503, Tamil Nadu, India.

Pure and Nd-doped cerium oxides (CeO₂, CeNdO and CeNdO) nanoparticles (NPs) were synthesized using leaf extract. X-ray powder diffraction studies were confirmed that synthesized pure and Nd doped CeO₂ NPs and were exhibited cubic structure. FE-SEM image exhibited pure and Nd doped CeO₂ NPs have spherical structure and Nd doped CeO2 NPs small pores were formed in the surface. Read More

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http://dx.doi.org/10.1166/jnn.2019.16307DOI Listing
July 2019
1 Read

New biomarkers of Kawasaki disease identified by urine proteomic analysis.

FEBS Open Bio 2019 Feb 20;9(2):265-275. Epub 2018 Dec 20.

Department of Cardiology Beijing Children's Hospital Capital Medical University Beijing China.

Kawasaki disease (KD) is an acute systemic vasculitis that mainly afflicts infants and young children. The symptoms of KD are similar to those of various febrile diseases. Here, we attempted to develop accurate diagnostic biomarkers of KD by performing urine proteomic analysis of samples from healthy controls, patients with KD, and patients with another febrile disease, pneumonia (two patients). Read More

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http://dx.doi.org/10.1002/2211-5463.12563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356163PMC
February 2019
1 Read

NrtR Regulates the Type III Secretion System Through cAMP/Vfr Pathway in .

Front Microbiol 2019 30;10:85. Epub 2019 Jan 30.

State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin, China.

The type III secretion system (T3SS) plays an important role in the pathogenesis of . Expression of the T3SS is controlled under a complicate regulatory network. In this study, we demonstrate that NrtR (PA4916) is involved in the T3SS expression and pathogenesis of in a mouse acute pneumonia model. Read More

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http://dx.doi.org/10.3389/fmicb.2019.00085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363681PMC
January 2019
1 Read

In vitro activities of antimicrobial peptides and ceragenins against Legionella pneumophila.

J Antibiot (Tokyo) 2019 Feb 12. Epub 2019 Feb 12.

Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Istanbul University, Beyazit, Istanbul, 34116, Turkey.

Legionella pneumophila is a waterborne intracellular pathogenic bacterium, the most frequent cause of human legionellosis and a relatively common cause of community-acquired and nosocomial pneumonia. Some legionellosis outbreaks are related to the presence of biofilms, which provide a reservoir for L. pneumophila strains. Read More

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http://dx.doi.org/10.1038/s41429-019-0148-1DOI Listing
February 2019
1 Read

High incidence of MDR and XDR Pseudomonas aeruginosa isolates obtained from patients with ventilator-associated pneumonia in Greece, Italy and Spain as part of the MagicBullet clinical trial.

J Antimicrob Chemother 2019 Feb 8. Epub 2019 Feb 8.

Microbiology Department, Biomedical Research Institute A Coruña (INIBIC), University Hospital A Coruña (CHUAC), University of A Coruña (UDC), A Coruña, Spain.

Objectives: To characterize the antimicrobial susceptibility, molecular epidemiology and carbapenem resistance mechanisms in Pseudomonas aeruginosa isolates recovered from respiratory tract samples from patients with ventilator-associated pneumonia enrolled in the MagicBullet clinical trial.

Methods: Isolates were collected from 53 patients from 12 hospitals in Spain, Italy and Greece. Susceptibility was determined using broth microdilution and Etest. Read More

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http://dx.doi.org/10.1093/jac/dkz030DOI Listing
February 2019
2 Reads

Dose Optimization of Colistin Combinations against Carbapenem-Resistant from Chinese Hospital-acquired Pneumonia Patients Using PK/PD Model.

Antimicrob Agents Chemother 2019 Feb 11. Epub 2019 Feb 11.

Institute of Antibiotics, Huashan Hospital, Fudan University & Key Laboratory of Clinical Pharmacology of Antibiotics, National Health and Family Planning Commission & National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, 200040, China

Colistin-based combination therapy has become an important strategy to combat the carbapenem-resistant (CRAB). However, the optimal dosage regimen selection for the combination with the maximum efficacy is challenging. Checkerboard assay was employed to evaluate the synergy of colistin in combination with meropenem, rifampicin, fosfomycin and minocycline against nine carbapenem-resistant (Minimum inhibitory concentration of meropenem [MIC]≥32 mg/L) isolated from Chinese hospital-acquired pneumonia (HAP) patients. Read More

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http://dx.doi.org/10.1128/AAC.01989-18DOI Listing
February 2019
1 Read

[Microbiological analysis as effective tool for optimization of empirical antibiotic therapy in the urological clinic].

Urologiia 2018 Dec(6):45-51

Federal State Budgetary Educational Institution of Higher Education Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation, Nizhny Novgorod.

Aim: to study the features of microbiota in patients of urological departments and to optimize the schemes of antibiotic therapy.

Materials And Methods: Data of microbiological studies in patients of urological departments in 2017 years were analyzed. Isolation of pathogens was carried out using standard techniques. Read More

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December 2018
1 Read

[The changes in urine microflora in patients with urinary stone disease].

Urologiia 2018 Dec(6):32-36

Urologic Clinic and Department of Urology.

Introduction: Since the results of treatment of chronic pyelonephritis (CP) depend on timely and rationally selected targeted antibiotic therapy, when choosing a treatment regimen, it is necessary to rely on the local data obtained by monitoring the state of microflora in a particular hospital.

Aim: to monitor the changes in urine microflora in patients with urinary stone disease.

Materials And Methods: A total of 598 isolated bacteria and yeast-like fungi from patients with urinary stone disease who were treated in the Department of Urology during different time periods (1997-1999, 2010-2014 and 2015-2017 yy) were analyzed. Read More

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December 2018
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Evaluation of the prevalence of Legionella pneumophila in Iranian clinical samples: A systematic review and meta-analysis.

Microb Pathog 2019 Feb 7;129:93-98. Epub 2019 Feb 7.

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical of Sciences, Mashhad, Iran; Neurogenic Inflammation Research Center, Mashhad University of Medical of Sciences, Mashhad, Iran; School of Pharmacy, Mashhad University of Medical of Sciences, Mashhad, Iran. Electronic address:

Background: Legionella pneumophila is the main cause for community-acquired pneumonia especially in hospital environments. In this systematic review and meta-analysis, we evaluated the prevalence of L. pneumophila in clinical samples obtained from Iranian patients. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.02.008DOI Listing
February 2019
2 Reads

Ten-year surveillance study of ventilator-associated pneumonia at a tertiary care center in Lebanon.

J Infect Public Health 2019 Feb 5. Epub 2019 Feb 5.

Division of Infectious Diseases, American University of Beirut Medical Center, Beirut, Lebanon; Infection Control and Prevention Program, American University of Beirut Medical Center, Beirut, Lebanon. Electronic address:

Background: Ventilator-associated pneumonia (VAP) is associated with significant adverse outcomes in critically-ill patients admitted to the Intensive Care Unit (ICU). Systematic data from Lebanon on VAP are not available and large epidemiological studies from the region are scarce.

Methods: We conducted a retrospective study over a 10-year period at the American University of Beirut Medical Center (AUBMC), a tertiary referral center in Lebanon in order to describe the incidence, microbiology, and temporal trends of VAP in the medical/surgical ICU. Read More

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http://dx.doi.org/10.1016/j.jiph.2019.01.057DOI Listing
February 2019
1 Read

Platelets inhibit apoptotic lung epithelial cell death and protect mice against infection-induced lung injury.

Blood Adv 2019 Feb;3(3):432-445

Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA.

Thrombocytopenia is associated with worse outcomes in patients with acute respiratory distress syndrome, which is most commonly caused by infection and marked by alveolar-capillary barrier disruption. However, the mechanisms by which platelets protect the lung alveolar-capillary barrier during infectious injury remain unclear. We found that natively thrombocytopenic mice deficient in the thrombopoietin receptor sustain severe lung injury marked by alveolar barrier disruption and hemorrhagic pneumonia with early mortality following acute intrapulmonary (PA) infection; barrier disruption was attenuated by platelet reconstitution. Read More

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http://dx.doi.org/10.1182/bloodadvances.2018026286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373758PMC
February 2019
2 Reads

Epidemiology of infection in mechanical circulatory support: A global analysis from the ISHLT Mechanically Assisted Circulatory Support Registry.

J Heart Lung Transplant 2019 Jan 17. Epub 2019 Jan 17.

James and John Kirklin Institute for Research in Surgical Outcomes (KIRSO), University of Alabama, Birmingham, Alabama.

Background: Despite advances in device technology and treatment strategies, infection remains a major cause of adverse events (AEs) in mechanical circulatory support (MCS) patients. To characterize the epidemiology of MCS infection, we examined the type, location, and timing of infection in the International Society for Heart and Lung Transplantation Registry (ISHLT) for Mechanically Assisted Circulatory Support (IMACS) over 3 years, 2013 to 2015.

Methods: Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) definitions were used to categorize AE infections occurring in MCS patients within IMACS. Read More

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http://dx.doi.org/10.1016/j.healun.2019.01.007DOI Listing
January 2019
1 Read

A case report of severe recurrent varicella in an ankylosing spondylitis patient treated with adalimumab - a new side effect after 15 years of usage.

BMC Infect Dis 2019 Feb 7;19(1):127. Epub 2019 Feb 7.

University Hospital for Infectious Diseases "Dr. Fran Mihaljević", Mirogojska 8, 10000, Zagreb, Croatia.

Background: Tumor necrosis factor-α (TNF-α) antagonists, most of which are monoclonal antibodies, became a widespread treatment for autoimmune diseases such as rheumatoid arthritis, ankylosing spondylitis, inflammatory bowel diseases, psoriasis, psoriatic arthritis, hidradenitis suppurativa and uveitis. Their use is based on the blockage of TNF-α, which plays an important role in granulomas formation, development of phagosomes, activation and differentiation of macrophages, immune response against viral pathogens. The multiple adverse effects of TNF-α inhibition have been identified, including a two-to four-fold increased risk of active tuberculosis and other granulomatous conditions and an increased occurrence of some other serious bacterial, fungal and certain viral infections. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
Publisher Site
http://dx.doi.org/10.1186/s12879-019-3768-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367735PMC
February 2019
2 Reads

A pilot study of the effects of Mycoplasma ovipneumoniae exposure on domestic lamb growth and performance.

PLoS One 2019 7;14(2):e0207420. Epub 2019 Feb 7.

Department of Animal Sciences, Washington State University College of Agricultural, Human, and Natural Resource Sciences, Pullman WA, United States of America.

Mycoplasma ovipneumoniae is a globally distributed pathogen that has been associated with pneumonia in both domestic and wild Caprinae. It is closely related to M. hyopneumoniae, a respiratory pathogen of swine that is associated with decreased growth rates of pigs as well as clinical respiratory disease. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207420PLOS
February 2019
1 Read

A year of terror and a century of reflection: perspectives on the great influenza pandemic of 1918-1919.

BMC Infect Dis 2019 Feb 6;19(1):117. Epub 2019 Feb 6.

Laboratory of Emerging and Re-Emerging Viruses, Department of Medical Microbiology, University of Manitoba, 523-745 Bannatyne Avenue, Winnipeg, MB, R3E 0J9, Canada.

Background: In the spring of 1918, the "War to End All Wars", which would ultimately claim more than 37 million lives, had entered into its final year and would change the global political and economic landscape forever. At the same time, a new global threat was emerging and would become one of the most devastating global health crises in recorded history.

Main Text: The 1918 H1N1 pandemic virus spread across Europe, North America, and Asia over a 12-month period resulting in an estimated 500 million infections and 50-100 million deaths worldwide, of which ~ 50% of these occurred within the fall of 1918 (Emerg Infect Dis 12:15-22, 2006, Bull Hist Med 76:105-115, 2002). Read More

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http://dx.doi.org/10.1186/s12879-019-3750-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364422PMC
February 2019
1 Read

Elaboration of consensus clinical endpoints to evaluate antimicrobial treatment efficacy in future HABP/VABP clinical trials.

Clin Infect Dis 2019 Feb 4. Epub 2019 Feb 4.

Jean-François Timsit, APHP Medical and Infectious Diseases ICU, Bichat Hospital, Paris, France UMR 1137 IAME Inserm/Université Paris Diderot, Paris, France.

Background: Randomized Clinical Trials (RCTs) in Hospital-Acquired (HABP) and Ventilator-Associated Bacterial Pneumonia (VABP) are important for the evaluation of new antimicrobials. However, the heterogeneity in endpoints used in RCTs evaluating treatment of HABP/VABP may puzzle clinicians. The aim of this work was to reach a consensus on clinical endpoints to consider in future clinical trials evaluating antimicrobial treatment efficacy for HABP/VABP. Read More

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http://dx.doi.org/10.1093/cid/ciz093DOI Listing
February 2019
1 Read

Enhancement of lung levels of antibiotics by ambroxol and bromhexine.

Expert Opin Drug Metab Toxicol 2019 Mar 7;15(3):213-218. Epub 2019 Feb 7.

b Department of Pharmaceutical Sciences, College of Pharmacy , University of New Mexico Health Sciences Center , Albuquerque , NM , USA.

Introduction: Major unmet needs remain for improved antibiotic treatment in lung infections. While development of new antibiotics is needed to overcome resistance, other approaches to optimize therapy using existing agents are also attractive. Ambroxol induces lung autophagy at human-relevant doses and improves lung levels of several approved antibiotics. Read More

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http://dx.doi.org/10.1080/17425255.2019.1578748DOI Listing
March 2019
4 Reads

Genetic polymorphisms associated with treatment failure and mortality in pediatric Pneumocystosis.

Sci Rep 2019 Feb 4;9(1):1192. Epub 2019 Feb 4.

All India Institute of Medical Sciences, Department of Nephrology, New Delhi, 110029, India.

Data on the genetic diversity of Pneumocystis jirovecii causing Pneumocystis pneumonia (PCP) among children are still limited, and there are no available data from the Indian subcontinent, particularly associations between genotypes and clinical characteristics. A total of 37 children (62 days-12 years [median 5.5 years]) were included in this study. Read More

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http://dx.doi.org/10.1038/s41598-018-38052-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361943PMC
February 2019
2 Reads
5.078 Impact Factor

Cefiderocol: A Siderophore Cephalosporin with Activity Against Carbapenem-Resistant and Multidrug-Resistant Gram-Negative Bacilli.

Drugs 2019 Feb 2. Epub 2019 Feb 2.

Department of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.

Cefiderocol is an injectable siderophore cephalosporin discovered and being developed by Shionogi & Co., Ltd., Japan. Read More

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http://dx.doi.org/10.1007/s40265-019-1055-2DOI Listing
February 2019
2 Reads

[Analysis on distribution and drug resistance of pathogen caused community-onset bloodstream infection].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2019 Jan;31(1):67-72

Department of Emergency-Critical Care Medicine, Huashan North Hospital, Fudan University, Shanghai 201907, China. Corresponding author: Xia Zhijie, Email:

Objective: To investigate the distribution and drug resistance of pathogen caused community-onset bloodstream infection (COBSI) in patients of affiliated hospital of university, and to provide evidence for the clinical therapy.

Methods: The clinical data of patients with COBSI in emergency department admitted to Huashan North Hospital Affiliated to Fudan University from January 2014 to December 2017 were collected, and the distribution and drug resistance of pathogen were retrospectively analyzed. The patients were divided into community-acquired bloodstream infection (CABSI) group and health care-associated bloodstream infection (HCABSI) group according to clinical diagnosis. Read More

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http://dx.doi.org/10.3760/cma.j.issn.2095-4352.2019.01.014DOI Listing
January 2019
2 Reads

Loop-mediated isothermal amplification-lateral-flow dipstick (LAMP-LFD) to detect Mycoplasma ovipneumoniae.

World J Microbiol Biotechnol 2019 Jan 30;35(2):31. Epub 2019 Jan 30.

College of Life Sciences, Shihezi University, Xin Jiang, Shihezi, 832000, China.

In order to establish a rapid detection method for Mycoplasma ovipneumoniae, this study used the loop-mediated isothermal amplification (LAMP) technique to carry out nucleic acid amplification and chromatographic visualization via a lateral flow dipstick (LFD) assay. The M. ovipneumoniae elongation factor TU gene (EF-TU) was detected using a set of specific primers designed for the EF-TU gene, and the EF-TU FIP was detected by biotin labeling, which was used in the LAMP amplification reaction. Read More

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http://dx.doi.org/10.1007/s11274-019-2601-5DOI Listing
January 2019
1 Read

The activity of commercial antimicrobials, and essential oils and ethanolic extracts of Olea europaea on Streptococcus agalactiae isolated from pregnant women.

BMC Complement Altern Med 2019 Jan 30;19(1):34. Epub 2019 Jan 30.

SAMRC Microbial Water Quality Monitoring Centre, University of Fort Hare, Private Bag X1314, Alice, Eastern Cape Province, 5700, South Africa.

Background: Streptococcus agalactiae also known as Group B Streptococcus (GBS) is a major cause of disease in pregnant women and new born babies where it causes early and late onset disease characterised by sepsis, pneumonia and meningitis. Ten to 37 % of pregnant women in the world are colonised with GBS while intrapartum antibiotic prophylaxis has led to significant reduction in early onset disease. The increase in drug resistant microorganisms has become a major threat. Read More

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http://dx.doi.org/10.1186/s12906-019-2445-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354339PMC
January 2019
3 Reads

The Role of the CopA Copper Efflux System in Virulence.

Int J Mol Sci 2019 Jan 29;20(3). Epub 2019 Jan 29.

Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide 5005, South Australia, Australia.

has emerged as one of the leading causative agents of nosocomial infections. Due to its high level of intrinsic and adapted antibiotic resistance, treatment failure rates are high, which allows this opportunistic pathogen to thrive during infection in immune-compromised patients. can cause infections within a broad range of host niches, with pneumonia and bacteraemia being associated with the greatest levels of morbidity and mortality. Read More

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http://dx.doi.org/10.3390/ijms20030575DOI Listing
January 2019
1 Read

A novel fusion gene involving PDGFRB and GCC2 in a chronic eosinophilic leukemia patient harboring t(2;5)(q37;q31).

Mol Genet Genomic Med 2019 Jan 29:e591. Epub 2019 Jan 29.

Division of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan.

Background: Platelet-derived growth factor receptor beta (PDGFRB) rearrangement has been reported in a number of patients with chronic eosinophilic leukemia (CEL), B-acute lymphoblastic leukemia, myeloproliferative neoplasms, and juvenile myelomonocytic leukemia. Here, we report a case of CEL carrying a novel fusion gene involving PDGFRB and GRIP and coiled-coil domain containing 2 (GCC2).

Patient And Methods: A 54-year-old man presenting with a cough and dyspnea was diagnosed with acute eosinophilic pneumonia. Read More

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http://doi.wiley.com/10.1002/mgg3.591
Publisher Site
http://dx.doi.org/10.1002/mgg3.591DOI Listing
January 2019
9 Reads

Esophageal intramural pseudodiverticulosis complicated with severe stricture requiring surgical resection.

Clin J Gastroenterol 2019 Jan 29. Epub 2019 Jan 29.

Department of Gastroenterology, Faculty of Medicine, Yamagata University, 2-2-2 Iida-Nishi, Yamagata, 990-9585, Japan.

Esophageal intramural pseudodiverticulosis (EIPD) is an uncommon benign disorder leading to esophageal strictures. The etiology remains unknown; however, anti-fungal treatments or endoscopic balloon dilation can improve early esophageal strictures and these rarely require surgical treatment. We report a case of a 46-year-old male with a 6 cm-long esophageal stricture due to EIPD, which did not improve following treatment with an anti-fungal agent, eventually causing aspiration pneumonia. Read More

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http://dx.doi.org/10.1007/s12328-019-00940-8DOI Listing
January 2019
1 Read

Diagnostic accuracy of chest ultrasound in patients with pneumonia in the intensive care unit: A single-hospital study.

Health Sci Rep 2019 Jan 26;2(1):e102. Epub 2018 Nov 26.

Respiratory Unit Ahmadi Hospital Ahmadi Kuwait.

Background And Aims: Chest radiography (CXR) and computerized tomography (CT) scan are the preferred methods for lung imaging in diagnosing pneumonia in the intensive care unit, in spite of their limitations. The aim of this study was to assess the performance of bedside lung ultrasound examination by a critical care physician, compared with CXR and chest CT, in the diagnosis of acute pneumonia in the ICU.

Materials And Methods: This was an observational, prospective, single-center study conducted in the intensive care unit of Ahmadi General Hospital. Read More

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http://dx.doi.org/10.1002/hsr2.102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346984PMC
January 2019
1 Read

Colonization of Pneumocystis jirovecii in Patients Who Received and not Received Corticosteroids Admitted to the Intensive Care Unit: Airborne Transmission Approach.

Iran J Pathol 2018 17;13(2):136-143. Epub 2018 Jul 17.

Dept. of Microbiology and Medical Parasitology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.

Background & Objective: pneumonia (PCP) is responsible for pulmonary infection in immunocompromised patients. The current study aimed at investigating the frequency of colonization in patients hospitalized in the intensive care unit (ICU) and evaluating the relationship between PCP and colonization.

Methods: The current cross sectional study was conducted on bronchoalveolar lavage (BAL) fluids of 100patients collected from surgery and neurosurgery ICUs with different underlying corticosteroid therapy conditions. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339491PMC
July 2018
3 Reads

Short-course versus long-course antibiotic treatment for community-acquired pneumonia: a literature review.

Basic Clin Pharmacol Toxicol 2019 Jan 29. Epub 2019 Jan 29.

Section of General Practice and Research Unit for General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.

Background: It is well known that antibiotic use is the main driver for the increasing problems with resistant bacteria. Consequently, some countries have recommended shortening the duration of antibiotic treatment of community-acquired pneumonia (CAP). The aim of this study was to investigate if the effectiveness of a short-course antibiotic is comparable to a longer course of antibiotics in adults with CAP and to assess if the duration of an antibiotic course influences the development of resistant bacteria. Read More

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http://dx.doi.org/10.1111/bcpt.13205DOI Listing
January 2019
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Analysis of the Pulmonary Microbiome Composition of Legionella pneumophila-Infected Patients.

Methods Mol Biol 2019 ;1921:429-443

Institut Pasteur, Biologie des Bactéries Intracellulaires, Paris, France.

The analysis of the lung microbiome composition is a field of research that recently emerged. It gained great interest in pulmonary diseases such as pneumonia since the microbiome seems to be involved in host immune responses, inflammation, and protection against pathogens. Thus, it is possible that the microbial communities living in the lungs play a role in the outcome and severity of lung infections such as Legionella-caused pneumonia and in the response to antibiotic therapy. Read More

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http://dx.doi.org/10.1007/978-1-4939-9048-1_27DOI Listing
January 2019
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The Mouse as a Model for Pulmonary Legionella Infection.

Methods Mol Biol 2019 ;1921:399-417

Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, Australia.

Infection of C57BL/6 mice with wild-type Legionella pneumophila typically results in very mild disease. However, in mice where the cytosolic recognition of flagellin is impaired by mutation, L. pneumophila infection results in more severe lung inflammation that is reminiscent of Legionnaires' disease. Read More

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http://dx.doi.org/10.1007/978-1-4939-9048-1_25DOI Listing
January 2019
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Migration of Acanthamoeba castellanii Through Legionella Biofilms.

Methods Mol Biol 2019 ;1921:79-89

Institute of Medical Microbiology, University of Zürich, Zürich, Switzerland.

The amoeba-resistant bacterium Legionella pneumophila infects humans through aerosols and thereby can cause a life-threatening pneumonia termed Legionnaires' disease. In the environment L. pneumophila forms and colonizes biofilms, which usually comprise complex multispecies communities. Read More

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http://dx.doi.org/10.1007/978-1-4939-9048-1_5DOI Listing
January 2019
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Staphylococcus pseudintermedius septicemia in puppies after elective cesarean section: confirmed transmission via dam's milk.

BMC Vet Res 2019 Jan 28;15(1):41. Epub 2019 Jan 28.

Clinic for Reproduction and Large Animals, Veterinary Faculty, University of Ljubljana, Gerbičeva 60, 1000, Ljubljana, Slovenia.

Background: In humans, transmission of bacteria causing fatal sepsis in the neonates through mother's milk has been reported. In dogs, it is believed that bacteria from canine milk are not the primary cause of neonatal infections. Staphylococcus pseudintermedius is colonizing the skin and mucocutaneous junctions in adult dogs and can act as an opportunistic pathogen. Read More

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http://dx.doi.org/10.1186/s12917-019-1795-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348621PMC
January 2019
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Effect of experimental Ornithobacterium rhinotracheale infection along with live infectious bronchitis vaccination in broiler chickens.

Poult Sci 2019 Jan;98(1):105-111

Department of Animal Production, College of Food and Agriculture Sciences, King Saud University, P.O. Box 2460, Riyadh 11451, Saudi Arabia.

Ornithobacterium rhinotracheale (ORT), a bacterium causing respiratory tract infection, has led to a significant problem in the intensive poultry production in Egypt. Polymerase chain reaction-amplified 784-bp specific ORT DNA fragments were found in 7 ORT isolates from lungs, air sacs, and tracheas of commercial broilers or layers in Egypt in 2015. The objective of this study was to investigate the role of the live variant IBV 4/91 with ORT infection. Read More

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http://dx.doi.org/10.3382/ps/pey324DOI Listing
January 2019
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A review of innate and adaptive immunity to coccidioidomycosis.

Med Mycol 2019 Feb;57(Supplement_1):S85-S92

Infectious Diseases Section, VA Healthcare San Diego, California, USA.

Coccidioidomycosis is a human fungal disease cause by inhalation of aerosol spores produced by Coccidioides posadasii or Coccidioides immitis. This disease is a common cause of community-acquired pneumonia in the endemic areas of the Southwestern United States. It also can present as a life-threatening disease as the fungal cells disseminate to skin, bone, and central nervous system. Read More

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http://dx.doi.org/10.1093/mmy/myy146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347076PMC
February 2019
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M. pneumoniae and C. pneumoniae are no relevant pathogens in critically ill patients with hospital-acquired respiratory tract infections.

Infection 2019 Jan 28. Epub 2019 Jan 28.

Institute for Infectious Diseases and Infection Control, Jena University Hospital, Am Klinikum 1, 07747, Jena, Germany.

Purpose: To assess the incidence of Mycoplasma pneumoniae and Chlamydia pneumoniae in the pathogenesis of hospital-acquired respiratory tract infections (RTIs) in critically ill patients.

Methods: This is a retrospective cohort study of all ICU-patients ≥ 18 years with RTI who underwent conventional culture techniques and PCR testing for both M. pneumoniae and C. Read More

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http://dx.doi.org/10.1007/s15010-019-01273-xDOI Listing
January 2019
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Agmatine accumulation by Pseudomonas aeruginosa clinical isolates confers antibiotic tolerance and dampens host inflammation.

J Med Microbiol 2019 Jan 28. Epub 2019 Jan 28.

1​Department of Microbiology & Immunology, University of Minnesota, Minneapolis, MN 55455, USA.

Purpose: In the cystic fibrosis (CF) airways, Pseudomonas aeruginosa undergoes diverse physiological changes in response to inflammation, antibiotic pressure, oxidative stress and a dynamic bioavailable nutrient pool. These include loss-of-function mutations that result in reduced virulence, altered metabolism and other phenotypes that are thought to confer a selective advantage for long-term persistence. Recently, clinical isolates of P. Read More

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http://dx.doi.org/10.1099/jmm.0.000928DOI Listing
January 2019
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Prevalence of extended-spectrum-β-lactamase-producing Klebsiella pneumonia: first systematic review and meta-analysis from Iran.

J Glob Antimicrob Resist 2019 Jan 24. Epub 2019 Jan 24.

Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Objectives: Extended-spectrum β-lactamases- producing Klebsiella pneumonia (ESBL-KP) have emerged as an important pathogen causing severe infection thought the world. Infections due to ESBL-KP are associated with high morbidity and mortality, especially in developing countries such as Iran. The aim of current study was to assess the pooled prevalence of ESBL-KP with different gene variants in Iran. Read More

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http://dx.doi.org/10.1016/j.jgar.2019.01.020DOI Listing
January 2019
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DNA-based bioassay of legionella pneumonia pathogen using gold nanostructure: A new platform for diagnosis of legionellosis.

Int J Biol Macromol 2019 Jan 24;128:692-699. Epub 2019 Jan 24.

Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

The specific diagnosis of hard-growing bacteria is one of the most important concerns of medical bacteriology. Legionella pneumophila is one of the most important bacteria in hard growth. In spite remarkable trends in bacteriology, now day, culture is the gold standard for detection of L. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.01.125DOI Listing
January 2019
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Avian H5N1 influenza virus infection causes severe pneumonia in the Northern tree shrew (Tupaia belangeri).

Virology 2019 Mar 19;529:101-110. Epub 2019 Jan 19.

Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Science, 2-1-6, Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan. Electronic address:

Avian-origin influenza viruses like H5N1 and H7N9 often cause severe symptoms with high mortality in humans. Animal models are useful for clarification of the mechanisms of pathogenicity of these infections. In this study, to expand the potential utility of the Northern tree shrew (Tupaia belangeri) for influenza virus infection, we assessed the pathogenicity of H5N1 and H7N9 avian influenza viruses in tupaia. Read More

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http://dx.doi.org/10.1016/j.virol.2019.01.015DOI Listing
March 2019
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Population-based estimates of the burden of pneumonia hospitalizations in Hong Kong, 2011-2015.

Eur J Clin Microbiol Infect Dis 2019 Mar 25;38(3):553-561. Epub 2019 Jan 25.

Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, Laboratory Block, University of Hong Kong, 2/F, 21 Sassoon Road, Hong Kong Special Administrative Region, China.

Up-to-date data on the burden of disease are important to identify patients with unmet needs and to optimize healthcare resources. We aimed to characterize the burden of pneumonia hospitalizations in Hong Kong and inform targeted healthcare policies for pneumonia control in the era of global aging. This was a population-based study using a territory-wide administrative electronic health record system that covers all public hospitals of Hong Kong. Read More

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http://dx.doi.org/10.1007/s10096-018-03459-xDOI Listing
March 2019
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Infectious complications following heart transplantation in the era of high-priority allocation and extracorporeal membrane oxygenation.

Ann Intensive Care 2019 Jan 25;9(1):17. Epub 2019 Jan 25.

Medical and Infectious Diseases Intensive Care Unit, AP-HP, Bichat-Claude Bernard University Hospital, 46 rue Henri Huchard, 75877, Paris Cedex, France.

Background: Infectious complications are a major cause of morbidity and mortality after heart transplantation (HT). However, the epidemiology and outcomes of these infections in the recent population of adult heart transplant recipients have not been investigated.

Methods: We conducted a single-center retrospective study on infectious complications occurring within 180 days following HT on consecutive heart transplant recipients, from January 2011 to June 2015 at Bichat University Hospital in Paris, France. Read More

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http://dx.doi.org/10.1186/s13613-019-0490-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347647PMC
January 2019
2 Reads