43,606 results match your criteria Pneumonia Fungal

Clinico-microbiological description and evaluation of rapid lateral flow immunoassay and PCR for detection of Burkholderia pseudomallei from patients hospitalized with sepsis and pneumonia: A twenty-one months study from Odisha, India.

Acta Trop 2021 Jun 9:105994. Epub 2021 Jun 9.

Department of Community and Family Medicine, AIIMS, Bhubaneswar. Electronic address:

Establishing a diagnosis of melioidosis based on clinical grounds is difficult in hospitalized patients with sepsis or community acquired pneumonia (CAP). We aimed to ascertain the prevalence, clinico-epidemiological and laboratory profile of melioidosis in hospitalized patients with sepsis or CAP, and to evaluate the diagnostic utility of rapid lateral flow immunoassay (LFI) and PCR in comparison with culture. In all patients with sepsis or CAP, blood, sputum/throat swab, and urine sample were subjected to culture along with other samples based on clinical presentation. Read More

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COVID-19-associated cavitating pneumonia.

BMJ Case Rep 2021 Jun 11;14(6). Epub 2021 Jun 11.

Microbiology and Infectious Diseases, The Royal London Hospital, London, UK.

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Improvement of pneumococcal pneumonia diagnosis using quantitative real-time PCR targeting lytA in adult patients: A prospective cohort study.

Clin Microbiol Infect 2021 Jun 8. Epub 2021 Jun 8.

Infectious Diseases Unit, Hospital Universitari Mútua de Terrassa, Barcelona; Universitat Internacional de Catalunya. Electronic address:

Objectives: The aim of the study was to assess the performance of real-time polymerase chain reaction (PCR) targeting the lytA gene (rtPCR-lytA) in plasma, urine and nasopharyngeal (NP) samples for the diagnosis of pneumococcal community-acquired pneumonia (P-CAP).

Methods: Prospective observational study including all consecutive adult CAP patients from November 2015 to May 2017. P-CAP was defined if pneumococcus was identified using conventional methods (CM) and/or a positive rtPCR-lytA was detected in blood, urine or NP samples (NP cut-off ≥8000 copies/mL). Read More

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The presence of SARS-CoV-2 virus in semen samples of patients with COVID-19 pneumonia.

Andrologia 2021 Jun 11:e14145. Epub 2021 Jun 11.

Department of Urology, University of Mersin School of Medicine, Mersin, Turkey.

The SARS-CoV-2 set off a pandemic involving millions of people around the world. The topic of discussion is the possible viral detection in different body fluids than respiratory droplets. Therefore, we evaluated the possible presence of SARS-CoV-2 in semen and urine samples. Read More

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Prophylaxis and treatment of influenza: options, antiviral susceptibility, and existing recommendations.

GMS Infect Dis 2021 30;9:Doc02. Epub 2021 Apr 30.

Section Experimental Virology, Department of Medical Microbiology, Jena University Hospital, Germany.

Influenza viruses of types A and B attack 5-10% of adults and 20-30% of children, thereby causing millions of acute respiratory infections in Germany annually. A significant number of these infections are associated with complications such as pneumonia and bacterial superinfections that need hospitalization and might lead to death. In addition to vaccines, drugs were developed that might support influenza prevention and that can be used to treat influenza patients. Read More

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SARS-CoV-2 Nonstructural Protein 1 Inhibits the Interferon Response by Causing Depletion of Key Host Signaling Factors.

J Virol 2021 06 10;95(13):e0026621. Epub 2021 Jun 10.

Department of Cell Biology, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Canada.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the ongoing coronavirus disease 2019 (COVID-19) pandemic. While previous studies have shown that several SARS-CoV-2 proteins can antagonize the interferon (IFN) response, some of the mechanisms by which they do so are not well understood. In this study, we describe two novel mechanisms by which SARS-CoV-2 blocks the IFN pathway. Read More

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Baicalin relieves infection‑induced lung injury through regulating microRNA‑221 to inhibit the TLR4/NF‑κB signaling pathway.

Mol Med Rep 2021 Aug 10;24(2). Epub 2021 Jun 10.

Department of Microbiology and Parasitology, China Medical University, Shenyang, Liaoning 110001, P.R. China.

(MP) is a common pathogen that can cause respiratory infections. MP pneumonia (MPP) leads to numerous complications, including lung injury and even death. The present study aimed to investigate the protective effects of Baicalin treatment on MP infection‑induced lung injury and the molecular mechanism underlying these effects. Read More

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Impact of intermediate to high-doses of methylprednisolone on mortality rate in patients with COVID-19 pneumonia-induced severe systemic inflammation.

Int J Clin Pract 2021 Jun 9:e14479. Epub 2021 Jun 9.

Medical Director, Doctor Peset University Hospital, Valencia, Spain.

Introduction: In addition to respiratory support needs, patients´ characteristics to guide indication or timing of corticosteroid treatment in COVID-19 patients are not completely established. This study aimed to evaluate the impact of methylprednisolone on mortality rate in patients with COVID-19 pneumonia-induced severe systemic inflammation (PI-SSI).

Methods: Between March 9 and May 5, 2020 (final follow-up July 2, 2020), a retrospective cohort study was conducted in hospitalized patients with COVID-19 PI-SSI (≥2 inflammatory biomarkers (IB): temperature ≥38ºC, lymphocyte ≤800cell/microL, C-reactive protein ≥100mg/L, lactate dehydrogenase ≥300units/L, ferritin ≥1000mcg/L, D-dimer ≥500ng/mL). Read More

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Relationship Between Chest Computed Tomography Findings and Clinical Conditions of Coronavirus Disease (COVID-19): A Multicentre Experience.

Int J Clin Pract 2021 Jun 9:e14459. Epub 2021 Jun 9.

Gazi University, Medical Faculty Department of Medical Microbiology, Division of Medical Virology Ankara, Turkey.

Aims: This study aimed to investigate the clinical and chest computed tomography (CT) features associated with clinical parameters for coronavirus disease (COVID-19) in the capital of Turkey, Ankara.

Materials And Methods: Epidemiological, clinical features, laboratory findings and radiological characteristics of 1,563 hospitalised patients with COVID-19 in Ankara were collected, reviewed and analysed in this study. The risk factors associated with disease severity were investigated. Read More

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The management of postoperative COVID-19 pneumonia in a case with right pneumonectomy.

Turk Gogus Kalp Damar Cerrahisi Derg 2021 Apr 26;29(2):275-278. Epub 2021 Apr 26.

Department of Thoracic Surgery, Ankara University School of Medicine, Ankara, Turkey.

A 61-year-old male patient was hospitalized for the evaluation of a lung mass. The patient underwent right pneumonectomy. Although reverse-transcription polymerase chain reaction tests were negative for COVID-19, the diagnosis was supported by thoracic computed tomography. Read More

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Seroprevalence study of SARS-CoV-2 antibodies in healthcare workers following the first wave of the COVID-19 pandemic in a tertiary-level hospital in the south of Ireland.

BMJ Open 2021 06 8;11(6):e051415. Epub 2021 Jun 8.

Department of Infectious Disease, Cork University Hospital, Cork, Ireland.

Objective: This study investigated seroprevalence of SARS-CoV-2-specific IgG antibodies, using the Abbott antinucleocapsid IgG chemiluminescent microparticle immunoassay (CMIA) assay, in five prespecified healthcare worker (HCW) subgroups following the first wave of the COVID-19 pandemic.

Setting: An 800-bed tertiary-level teaching hospital in the south of Ireland.

Participants: Serum was collected for anti-SARS-CoV-2 nucleocapsid IgG using the Abbott ARCHITECT SARS-CoV-2 IgG CMIA qualitative assay, as per the manufacturer's specifications. Read More

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Heparin-binding protein in lower airway samples as a biomarker for pneumonia.

Respir Res 2021 Jun 8;22(1):174. Epub 2021 Jun 8.

Department of Infectious Diseases, Skåne University Hospital, Lund, Sweden.

Objectives: Ventilator-associated pneumonia (VAP) is difficult to diagnose using clinical criteria and no biomarkers have yet been proved to be sufficiently accurate. The use of the neutrophil-derived Heparin-binding protein (HBP) as a biomarker for pneumonia was investigated in this exploratory case-control study in two intensive care units at a tertiary referral hospital.

Methods: Patients with clinical signs of pneumonia were recruited and bronchoalveolar lavage fluid (BALF) or bronchial wash (BW) samples were collected. Read More

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Growth and Stress Tolerance Comprise Independent Metabolic Strategies Critical for Staphylococcus aureus Infection.

mBio 2021 Jun 8:e0081421. Epub 2021 Jun 8.

Department of Pathology, Immunology and Laboratory Medicine, Rutgers New Jersey Medical School, Newark, New Jersey, USA.

Staphylococcus aureus is an important pathogen that leads to high morbidity and mortality. Although S. aureus produces many factors important for pathogenesis, few have been validated as playing a role in the pathogenesis of S. Read More

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Invasive Group A Streptococcus Infection in Children in Central Israel in 2012-2019.

Pediatr Infect Dis J 2021 Jul;40(7):612-616

From the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: Group A Streptococcus can cause serious and sometimes life-threatening disease in children. The past few years have witnessed a rise in invasive group A Streptococcus infection (iGASi) for unclear reasons. This study attempted to describe the epidemiology, the clinical and demographic characteristics and the outcomes associated with iGASi in hospitalized children in central Israel. Read More

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Can We Protect Those We Care for in A Pandemic? - Prevalence of Neutralizing Antibodies against SARS-CoV-2 in Nursing Homes.

Aging Dis 2021 Jun 1;12(3):710-717. Epub 2021 Jun 1.

10Paracelsus Medical University of Salzburg, Salzburg, Austria.

In December 2019, the People's Republic of China and the World Health Organization first reported on a cluster of pneumonia with an unknown cause. Nine months later more than 1.4 million people have died from COVID 19. Read More

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Can Resveratrol-Inhaled Formulations Be Considered Potential Adjunct Treatments for COVID-19?

Front Immunol 2021;12:670955. Epub 2021 May 19.

Department of Public Health and Infectious Diseases, Microbiology Section, University of Rome "Sapienza", Rome, Italy.

The pandemic caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) has led to an extraordinary threat to the global healthcare system. This infection disease, named COVID-19, is characterized by a wide clinical spectrum, ranging from asymptomatic or mild upper respiratory tract illness to severe viral pneumonia with fulminant cytokine storm, which leads to respiratory failure. To improve patient outcomes, both the inhibition of viral replication and of the unwarranted excessive inflammatory response are crucial. Read More

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The Persistent Challenge of Pneumocystis Growth Outside the Mammalian Lung: Past and Future Approaches.

Front Microbiol 2021 20;12:681474. Epub 2021 May 20.

Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States.

The pathogenic fungi in the genus, Pneumocystis, have eluded attempts to continuously grow them in an cultivation system. New data from transcriptomic and genomic sequencing studies have identified a myriad of absent metabolic pathways, helping to define their host obligate nature. These nutrients, factors, and co-factors are acquired from their mammalian host and provide clues to further supplementation of existing media formulations. Read More

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Incidence of Device Associated-Healthcare Associated Infections from a Neurosurgical Intensive Care Unit of a Tertiary Care Center: A Retrospective Analysis.

Anesth Essays Res 2020 Jul-Sep;14(3):454-460. Epub 2021 Mar 22.

Department of Neurosurgery, Amrita school of Medicine, AIMS, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India.

Background: Deviceassociated infections (DAIs) increase the morbidity and mortality in the intensive care unit (ICU). Studies from the neurosurgical ICU in developing countries are sparse.

Aims: The aim of this study was to assess the incidence of device-associated healthcare associated infections, pathogens isolated, antibiotic resistance, and mortality in neurosurgical ICU. Read More

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Comparative Evaluation of the Role of Nonbronchoscopic and Bronchoscopic Techniques of Distal Airway Sampling for the Diagnosis of Ventilator-Associated Pneumonia.

Anesth Essays Res 2020 Jul-Sep;14(3):434-440. Epub 2021 Mar 22.

Department of Anaesthesiology and Critical Care, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Background: The diagnosis of ventilator-associated pneumonia (VAP) remains a challenge, with clinicians mainly relying on clinical, radiological, and bacteriologic strategies to manage patients with VAP.

Aims: To compare the results of non-bronchoscopic and bronchoscopic techniques of distal airway sampling for the diagnosis of VAP.

Settings And Design: This was a single-center prospective diagnostic accuracy study done in the 14-bedded intensive care unit of a tertiary care referral hospital. Read More

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Effect of the Photocatalyst under Visible Light Irradiation in SARS-CoV-2 Stability on an Abiotic Surface.

Biocontrol Sci 2021 ;26(2):119-125

Division of Biomedical Food Research, National Institute of Health Sciences.

There is a worldwide attempt to develop prevention strategies against SARS-CoV-2 transmission. Here we examined the effectiveness of tungsten trioxide (WO)-based visible light-responsive photocatalyst on the inactivation of SARS-CoV-2 under different temperatures and exposure durations. The viral titer on the photocatalyst-coated glass slides decreased from 5. Read More

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Legionnaires' disease arising with hirsutism: case report of an extremely confusing event.

BMC Infect Dis 2021 Jun 6;21(1):532. Epub 2021 Jun 6.

Department of Interdisciplinary Medicine, Occupational Health Division, University of Bari, Bari, Italy.

Background: Legionella bacteria is a common cause of pneumonia, but the infection may affect several organs in the most serious cases. A systemic involvement ab initio could be non-specific, leading to a diagnostic misinterpretation.

Case Presentation: A 33-year-old woman had been complaining of mental confusion, restlessness, aggressiveness, and, subsequently, hirsutism. Read More

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Pediatric Staphylococcus aureus bacteremia: clinical spectrum and predictors of poor outcome.

Clin Infect Dis 2021 Jun 5. Epub 2021 Jun 5.

Department of Infectious Diseases, Perth Children's Hospital, Nedlands.

Background: Staphylococcus aureus is a common cause of bacteremia, yet the epidemiology, and predictors of poor outcome remain inadequately defined in childhood.

Methods: ISAIAH is a prospective, cross-sectional study of S. aureus bacteremia (SAB), in children hospitalized in Australia and New Zealand, over 24-months (2017-2018). Read More

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Atypical Inflammatory Syndrome Triggered by SARS-CoV-2 in Infants with Down Syndrome.

J Clin Immunol 2021 Jun 5. Epub 2021 Jun 5.

Center for Inborn Errors of Immunity, Icahn School of Medicine At Mount Sinai, New York, NY, USA.

While adults with Down syndrome (DS) are at increased risk of severe COVID-19 pneumonia, little is known about COVID-19 in children with DS. In children without DS, SARS-CoV-2 can rarely cause severe COVID-19 pneumonia, or an even rarer and more typically pediatric condition, multisystem inflammatory syndrome in children (MIS-C). Although the underlying mechanisms are still unknown, MIS-C is thought to be primarily immune-mediated. Read More

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Modified Lung Ultrasound Score in Evaluating the Severity of Covid-19 Pneumonia.

Ultrasound Med Biol 2021 Apr 30. Epub 2021 Apr 30.

Department of Public Health, Faculty of Medicine, KahramanmarasSutcu Imam University, Kahramanmaras, Turkey. Electronic address:

Severe acute respiratory syndrome coronavirus 2 causes coronavirus disease 2019 (Covid-19), which has been declared as a pandemic by the World Health Organization. The aim of the study described here was to determine the severity of pneumonia and the clinical parameters related to a modified lung ultrasound score (mLUS) in patients with COVID-19 pneumonia. The study included 44 patients with proven COVID-19 pneumonia. Read More

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rcent agreement; NPA: negative percent agreeRapid identification of bacteria from respiratory samples of patients hospitalized in intensive care units, with FilmArray Pneumonia Panel Plus.

Int J Infect Dis 2021 Jun 1. Epub 2021 Jun 1.

Department of Microbiology, Saint-Louis-Lariboisière Hospital Group, Assistance Publique - Hôpitaux de Paris, Paris, France; University of Paris, INSERM 1137, IAME, Paris, France. Electronic address:

Objectives: We evaluated the performance of FilmArray Pneumonia Panel Plus (FA-PP) for detecting typical bacterial pathogens in respiratory specimens from patients hospitalized in the ICU.

Methods: We implemented FA-PP for clinical use in the microbiology laboratory in March 2020. We performed a retrospective analysis on a consecutive cohort of adult patient hospitalized in ICUs between March 2020 and May 2020. Read More

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Metabolomic profiling of microbial disease etiology in community-acquired pneumonia.

PLoS One 2021 4;16(6):e0252378. Epub 2021 Jun 4.

Division of Systems Biomedicine & Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.

Diagnosis of microbial disease etiology in community-acquired pneumonia (CAP) remains challenging. We undertook a large-scale metabolomics study of serum samples in hospitalized CAP patients to determine if host-response associated metabolites can enable diagnosis of microbial etiology, with a specific focus on discrimination between the major CAP pathogen groups S. pneumoniae, atypical bacteria, and respiratory viruses. Read More

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Surgical Complications After Deceased Donor Renal Transplant.

Exp Clin Transplant 2021 Jun 3. Epub 2021 Jun 3.

From the Department of General Surgery, Faculty of Medicine, Gazi University, Ankara, Turkey.

Objectives: Deceased donor renal transplant is an accepted treatment for patients with end-stage renal disease. We retrospectively analyzed urological and surgical complications and outcomes in our series.

Material And Methods: Since 2016, we have performed 263 renal transplants at the Gazi University Transplantation Center, Ankara, and 92 of these were from deceased donors. Read More

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Influence of microbiological culture results on antibiotic choices for veterans with hospital-acquired pneumonia and ventilator-associated pneumonia.

Infect Control Hosp Epidemiol 2021 Jun 4:1-8. Epub 2021 Jun 4.

Geriatric Research Education and Clinical Center (GRECC), the VA Northeast Ohio Healthcare System, Cleveland, Ohio.

Objective: We examined the impact of microbiological results from respiratory samples on choice of antibiotic therapy in patients treated for hospital-acquired pneumonia (HAP) or ventilator-associated pneumonia (VAP).

Design: Four-year retrospective study.

Setting: Veterans' Health Administration (VHA). Read More

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Angiotensin-converting enzyme-1 gene insertion/deletion polymorphism may be associated with COVID-19 clinical severity: a prospective cohort study.

Ann Saudi Med 2021 May-Jun;41(3):141-146. Epub 2021 Jun 1.

From the Department of Internal Medicine, Section of Rheumatology, Samsun Education and Research Hospital, Samsun, Turkey.

Background: Angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism may play a role in the pathogenesis of coronavirus-19 disease (COVID-19).

Objectives: Investigate the relationship between ACE I/D polymorphism and the clinical severity of COVID-19.

Design: Prospective cohort study. Read More

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Pathogens and drug-resistance of hospital-acquired pneumonia in an EICU in Tianjin, China.

Int J Biochem Mol Biol 2021 15;12(2):49-54. Epub 2021 Apr 15.

Deputy Director of ED of Tianjin Medical University General Hospital Tianjin, China.

Objective: Observing the pathogens and drug-resistance within hospital-acquired pneumonia (HAP) in an emergency intensive care unit (EICU) to provide a reference for clinically reasonable use of antibiotics.

Methods: Sixty-two patients with HAP in Tianjin Medical University General Hospital from January 2017 to May 2019 were analyzed retrospectively. Bacterial identification and susceptibility were reviewed. Read More

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