12,770 results match your criteria Pneumonia Community-Acquired


Burden of pneumococcal disease: 8-year retrospective analysis from a single centre in Hong Kong.

Hong Kong Med J 2020 Jul 9. Epub 2020 Jul 9.

Department of Intensive Care, Pamela Youde Nethersole Eastern Hospital, Hong Kong.

Purpose: is a common pathogen involved in community-acquired pneumonia. Invasive pneumococcal disease is often associated with higher co-morbidity rates, but mortality-related findings have been inconclusive. This study investigated predictors of 30-day mortality and invasive pneumococcal disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12809/hkmj208373DOI Listing

Management of Community-Acquired Pneumonia in Pediatrics: Adherence to Clinical Guidelines.

Front Pediatr 2020 19;8:302. Epub 2020 Jun 19.

Division of Pediatric Pulmonology, Department of Pediatrics, Hotel Dieu de France University Medical Center, Saint Joseph University, Beirut, Lebanon.

To evaluate adherence to guidelines for inpatient care of pediatric patients with community-acquired pneumonia (CAP). Pediatric CAP is one of the most common acute infections requiring hospital admission. Discrepancies between recommended care and effective management are reported, raising the necessity to evaluate our local clinical practices. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fped.2020.00302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316885PMC

Clinical characteristics and outcomes of patients with H1N1 influenza pneumonia admitted at a tertiary care hospital in Karachi, Pakistan.

Pneumonia (Nathan) 2020 5;12. Epub 2020 Jul 5.

Department of Pathology and Laboratory Medicine, Section of Molecular Pathology, Aga Khan University, Karachi, Pakistan.

Introduction: Influenza viruses specifically, A and B mainly contribute to seasonal outbreaks that occur globally. However, due to limited diagnostics for influenza there is little data regarding clinical outcomes of patients with H1N1 pneumonia in our region. Our objective was to determine the clinical characteristics and outcomes of patients hospitalized with H1N1 pneumonia at a tertiary care facility in Karachi, Pakistan. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s41479-020-00070-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335362PMC

Pathophysiology of Hyperkalemia Presenting as Brugada Pattern on Electrocardiogram (ECG).

Am J Case Rep 2020 Jul 8;21:e923464. Epub 2020 Jul 8.

Department of Emergency Medicine, University of Kentucky Hospital, Lexington, KY, USA.

BACKGROUND Brugada phenocopies (BrP) are clinical and electrocardiographic (ECG) entities elicited by reversible medical conditions speculated to have pathogenesis rooted in ion current imbalances or conduction delays within the myocardial wall. During an inciting pathologic condition, it produces ECG patterns identical to those of congenitally-acquired Brugada syndrome and subsequently returns to normal ECG patterns upon resolution of the medical condition. This case report describes a 26-year-old man presenting to the Emergency Department (ED) for suspected heroin overdose with a rare ECG consistent with BrP secondary to acute hyperkalemia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/AJCR.923464DOI Listing

Current Concepts in Community and Ventilator Associated Lower Respiratory Tract Infections in ICU Patients.

Antibiotics (Basel) 2020 Jul 5;9(7). Epub 2020 Jul 5.

Department of Anaesthesia and Critical Care Medicine, St James's Hospital, D08 X4RX Dublin, Ireland.

It is widely known that pneumonia (either community acquired or hospital acquired, as like ventilator associated pneumonia (VAP)), is the most frequent type of severe infection and continues to pose a significant burden on healthcare services worldwide. Despite new diagnostic developments, most pneumonia cases continue to be difficult to diagnose clinically, partly due to acquired antibiotic resistance and the lack of a 'gold standard' method of diagnosis. In other words, the lack of a rapid, accurate diagnostic test, as well as the uncertainty of the initial etiologic diagnosis and the risk stratification, results in empirical antibiotic treatments. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/antibiotics9070380DOI Listing

Lactate dehydrogenase, an independent risk factor of severe COVID-19 patients: a retrospective and observational study.

Aging (Albany NY) 2020 06 24;12(12):11245-11258. Epub 2020 Jun 24.

Emergency Department, Zhongshan Hospital, Fudan University, Shanghai 20032, China.

Background: The World Health Organization has declared coronavirus disease 2019 (COVID-19) a public health emergency of global concern. Updated analysis of cases might help identify the risk factors of illness severity.

Results: The median age was 63 years, and 44. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103372DOI Listing

Dynamics of the lung microbiome in intensive care patients with chronic obstructive pulmonary disease and community-acquired pneumonia.

Sci Rep 2020 Jul 6;10(1):11046. Epub 2020 Jul 6.

Department of Life Sciences, National Chung Hsing University, 145 Xingda Rd., South Dist., Taichung, 402, Taiwan.

Little is known about the composition and clinical implications of lung microbiome in patients with chronic obstructive pulmonary disease (COPD) and community-acquired pneumonia requiring invasive mechanical ventilation and intensive care unit admission. Therefore, this study aimed to explore the longitudinal changes in microbial airway composition and its variations between COPD patients with different weaning outcomes. Fifty-one endotracheal aspirate samples from 21 participants and 5 saline samples were collected as the patient and control group, respectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-020-68100-4DOI Listing

Incidence, mortality, and lethality of hospitalizations for community-acquired pneumonia with comorbid cardiovascular disease in Spain (1997-2015).

BMC Infect Dis 2020 Jul 6;20(1):477. Epub 2020 Jul 6.

Area of Preventive Medicine & Public Health, Rey Juan Carlos University, Avda. Atenas s s/n, 28922, Alcorcón (Madrid), Spain.

Background: The probability of hospitalization in patients suffering from community-acquired pneumonia (CAP) with an underlying comorbidity, such as a cardiac pathology, is 73-fold higher than that in CAP patients without a comorbidity. Although previous studies have investigated patients with cardiac events and pneumonia, they have not studied the burden of disease in depth at the population level. The objective of this study is to provide population-level data on patients ≥60 years old who were hospitalized with pneumonia with comorbid cardiovascular disease (CVD) in Spain over a period of 19 years (1997-2015). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12879-020-05208-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336298PMC

[Severe community-acquired pneumonia caused by Legionella pneumophila with acute respiratory failure: clinical characteristics and prognosis of 34 cases].

Zhonghua Jie He He Hu Xi Za Zhi 2020 Jul;43(7):557-563

Department of Respiratory and Critical Care Medicine, Beijing Chaoyang Hospital, Capital Medical University; Beijing Institute of Respiratory Medicine; Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders; Beijing Engineering Research Center for Diagnosis and Treatment of Respiratory and Critical Care Medicine (Beijing Chaoyang Hospital), Beijing 100020, China.

To describe the clinical characteristics and treatment of severe community-acquired pneumonia(SCAP) caused by Legionella pneumophila with acute respiratory failure and to analyze the risk factors for mortality. From October 2011 to October 2019, 34 patients were diagnosed with SCAP caused by Legionella pneumophila with acute respiratory failure.There were 25 males and 9 females, aged from 17 to 82 years, with a median age of 61 (48, 69) years. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.cn112147-20200114-00023DOI Listing

Other Respiratory Viruses as a Cause of Community-Acquired Pneumonia.

Authors:
James M Walter

Semin Respir Crit Care Med 2020 Aug 6;41(4):579-591. Epub 2020 Jul 6.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Community-acquired pneumonia (CAP) is a major cause of morbidity and mortality worldwide. There is growing appreciation of the burden of noninfluenza viral pathogens in CAP. Due to multiple factors including pneumococcal vaccination programs, declining rates of cigarette smoking, an aging population, and increasingly sensitive diagnostic tests, respiratory viruses are now the most common pathogens detected in CAP, outpacing . Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0040-1710537DOI Listing

Nocardia spp.: A Rare Cause of Pneumonia Globally.

Semin Respir Crit Care Med 2020 Aug 6;41(4):538-554. Epub 2020 Jul 6.

Division of Infectious Diseases, Loyola University Medical Center, Maywood, Illinois.

Members of the genus are ubiquitous in the environment. These aerobic, gram-positive organisms can lead to life-threatening infection, typically in immunocompromised hosts such as solid organ transplant recipients or those receiving immunosuppressive medications for other reasons. This current review discusses the microbiology of nocardiosis, risk factors for infection, clinical manifestations, methods for diagnosis, and treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0040-1708816DOI Listing

Endemic Fungi Presenting as Community-Acquired Pneumonia: A Review.

Semin Respir Crit Care Med 2020 Aug 6;41(4):522-537. Epub 2020 Jul 6.

Indiana University, School of Medicine, Pulmonary Critical Care Medicine, Thoracic Transplantation Program, Indianapolis, Indiana.

In endemic areas, dimorphic fungal infections due to , and account for up to 30% of cases of community-acquired pneumonia. Because respiratory manifestations are often indistinguishable from common bacterial causes of pneumonia, the diagnosis of pulmonary histoplasmosis, blastomycosis, and coccidioidomycosis is often delayed and associated with antibiotics overuse. In addition to being highly endemic to certain regions of North America, dimorphic fungi have global significance due to established areas of endemicity in all six inhabited continents, an increasingly interconnected world of travelers and transported goods, and a changing epidemiology as a result of global heating and anthropomorphic land utilization. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0040-1702194DOI Listing

Melioidosis: A Neglected Cause of Community-Acquired Pneumonia.

Semin Respir Crit Care Med 2020 Aug 6;41(4):496-508. Epub 2020 Jul 6.

Center for Experimental and Molecular Medicine, Amsterdam Infection & Immunity Institute, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

Melioidosis, caused by the facultative intracellular gram-negative pathogen , is an emerging cause of community-acquired pneumonia across the tropics. The majority of patients present with pneumonia with or without sepsis, but localized and asymptomatic infection is also well recognized. Recent modeling and epidemiological studies have demonstrated the widespread presence of in otherwise unrecognized regions with a predicted mortality of 90,000 deaths worldwide. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0040-1710570DOI Listing

Emerging Resistance of Gram Negative Pathogens in Community-Acquired Pneumonia.

Semin Respir Crit Care Med 2020 Aug 6;41(4):480-495. Epub 2020 Jul 6.

Division of Pulmonary Diseases and Critical Care Medicine, University of Texas Health, San Antonio, San Antonio, Texas.

In recent decades, there has been a growing interest about the role of gram negative bacteria in community-acquired pneumonia (CAP), especially , , and . The prevalence of these pathogens differs largely according to the local ecology and the geographical location. Identifying gram negative bacteria, and in particular resistant gram negative bacteria, is of paramount importance in patients with CAP because these pathogens are associated with higher clinical severity and unfavorable outcomes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0040-1709137DOI Listing

The Role of Streptococcus pneumoniae in Community-Acquired Pneumonia.

Semin Respir Crit Care Med 2020 Aug 13;41(4):455-469. Epub 2020 Jun 13.

Department of Immunology and Institute of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.

With the notable exceptions of the United States and Canada in particular, the global burden of disease in adults due to invasive infection with the dangerous respiratory, bacterial pathogen, (pneumococcus) remains. This situation prevails despite the major successes of inclusion of polysaccharide conjugate vaccines (PCVs) in many national childhood immunization programs and associated herd protection in adults, as well as the availability of effective antimicrobial agents. Accurate assessment of the geographic variations in the prevalence of invasive pneumococcal disease (IPD) has, however, been somewhat impeded by the limitations imposed on the acquisition of reliable epidemiological data due to reliance on often insensitive, laboratory-based, pathogen identification procedures. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0040-1702193DOI Listing

Community-Acquired Pneumonia: A Global Perspective.

Semin Respir Crit Care Med 2020 Aug 6;41(4):453-454. Epub 2020 Jul 6.

Faculty of Health Sciences, University of the Witwatersrand Medical School, Johannesburg, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0040-1713003DOI Listing

Comparison of Venous Thromboembolism Risks Between COVID-19 Pneumonia and Community-Acquired Pneumonia Patients.

Arterioscler Thromb Vasc Biol 2020 Jul 6:ATVBAHA120314779. Epub 2020 Jul 6.

Division of Vascular and Endovascular Surgery, Department of Surgery, University of Washington and Puget Sound VA Health Care System, Seattle (W.W.Z.).

Objective: The objectives were to investigate and compare the risks and incidences of venous thromboembolism (VTE) between the 2 groups of patients with coronavirus disease 2019 (COVID-19) pneumonia and community-acquired pneumonia (CAP). Approach and Results: Medical records of 616 pneumonia patients who were admitted to the Yichang Central People's Hospital in Hubei, China, from January 1 to March 23, 2020, were retrospectively reviewed. The patients with COVID-19 pneumonia were treated in the dedicated COVID-19 units, and the patients with CAP were admitted to regular hospital campus. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/ATVBAHA.120.314779DOI Listing

[Meta-analysis and trial sequential analysis of Qingjin Huatan Decoction for treating community-acquired pneumonia in elderly].

Zhongguo Zhong Yao Za Zhi 2020 Jun;45(11):2658-2667

the First Affiliated Hospital, Guangzhou University of Chinese Medicine Guangzhou 510405, China.

To systematically evaluate the clinical efficacy and safety of modified Qingjin Huatan Decoction in the treatment of community-acquired pneumonia in the elderly, and provide evidence-based reference for the clinical application of this prescription. Randomized controlled trials of Qingjin Huatan Decoction in the treatment of community-acquired pneumonia in the elderly were collected by searching PubMed, EMbase, Cochrane Library, CNKI, China Biomedical Literature database, VIP database and WanFang database. Outcome indicators included clinical effective rate, inflammation index, symptom improvement time, chest radiograph improvement time, hospitalization time and adverse reactions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.19540/j.cnki.cjcmm.20191226.501DOI Listing

Use of Lung Ultrasound to Differentiate Coronavirus Disease 2019 (COVID-19) Pneumonia From Community-Acquired Pneumonia.

Ultrasound Med Biol 2020 Jun 5. Epub 2020 Jun 5.

Collaborative Innovation Center for Maternal and Infant Health Service Application Technology of Education Ministry, Quanzhou Medical College, Fujian, China; Department of Ultrasound Medicine, Second Affiliated Hospital of Fujian Medical University, Fujian, China; Department of Ultrasound Medicine, Zhangzhou Municipal Hospital, Fujian, China; Affiliated Hospital of Quanzhou Medical College, Quanzhou, China; Jinjiang Municipal Hospital, Fujian, China. Electronic address:

To investigate the feasibility of lung ultrasound in evaluating coronavirus disease 2019 (COVID-19) and distinguish the sonographic features between COVID-19 and community-acquired pneumonia (CAP), a total of 12 COVID-19 patients and 20 CAP patients were selected and underwent lung ultrasound. The modified Buda scoring system for interstitial lung disease was used to evaluate the severity and treatment effect of COVID-19 on ultrasonography. The differences between modified lung ultrasound (MLUS) score and high-resolution computed tomography (HRCT) Warrick score were analyzed to evaluate their correlation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ultrasmedbio.2020.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274602PMC

No SARS-CoV-2 detection in the German CAPNETZ cohort of community acquired pneumonia before COVID-19 peak in March 2020.

Infection 2020 Jul 3. Epub 2020 Jul 3.

Department of Internal Medicine II, School of Medicine, Technical University Munich, University Hospital rechts der Isar, Munich, Germany.

Purpose: The first SARS-CoV-2 cases in Europe were reported in January 2020. Recently, concern arose on unrecognized infections before this date. For a better understanding of the pandemic, we retrospectively analyzed patient samples for SARS-CoV-2 from the prospective CAPNETZ study cohort. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s15010-020-01471-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332473PMC

Community-Acquired Pneumonia: Treatment Options for Adults.

Authors:

J Infus Nurs 2020 Jul/Aug;43(4):191-192

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/NAN.0000000000000383DOI Listing

Community-Acquired Pneumonia: Treatment Options for Adults.

Authors:
Susan Kleppin

J Infus Nurs 2020 Jul/Aug;43(4):187-190

Chartwell Midwest Wisconsin, Middleton, Wisconsin. Susan Kleppin, RPh, FASHP, is director of pharmacy at Chartwell Midwest Wisconsin.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/NAN.0000000000000378DOI Listing

Venous Thromboembolism Events Following Venovenous Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Syndrome Coronavirus 2 Based on CT Scans.

Crit Care Med 2020 Jun 26. Epub 2020 Jun 26.

1Médecine Intensive Réanimation Détresses Respiratoires et Infection Sévères, AP-HM, CHU Nord, Marseille, France. 2CEReSS - Center for Studies and Research on Health Services and Quality of Life EA3279, Aix-Marseille University, Marseille, France. 3Service d'Imagerie Médicale, AP-HM, CHU Nord, Marseille, France. 4Département de Chirurgie Cardiaque, AP-HM, CHU Timone, Marseille, France.

Objectives: The main objective of the study was to determine the prevalence of venous thromboembolism events in patients infected with severe acute respiratory syndrome coronavirus 2 requiring venovenous extracorporeal membrane oxygenation. The secondary objective was to compare venous thromboembolism events and coagulation variables in patients requiring venovenous extracorporeal membrane oxygenation according to the pathogen.

Design: Retrospective observational analysis at a single center. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/CCM.0000000000004504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328443PMC

Late atrioventricular groove disruption presenting 7 years after mitral valve replacement: a case report.

Eur Heart J Case Rep 2020 Jun 1;4(3):1-5. Epub 2020 May 1.

Department of Cardiovascular Surgery, Hospital das Clínicas, Universidade Federal de Minas Gerais, Avenida Professor Alfredo Balena n 110, Belo Horizonte MG 30.130-100, Brazil.

Background: Left ventricular rupture is the most feared complication in mitral valve surgery. Despite its low incidence, mortality rates can reach up to 75%. It usually presents on the operating room with a dissecting haematoma followed by massive bleeding after discontinuing cardiopulmomary bypass. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ehjcr/ytaa091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319809PMC

Health-Related Quality of Life as Measured by the 12-Item Short-Form Survey Among Adults With Community-Acquired Bacterial Pneumonia who Received Either Lefamulin or Moxifloxacin in 2 Phase III Randomized, Double-Blind, Double-Dummy Clinical Trials.

Open Forum Infect Dis 2020 Jun 3;7(6):ofaa209. Epub 2020 Jun 3.

Nabriva Therapeutics US, Inc., King of Prussia, Pennsylvania, USA.

Background: Interest in patient-reported outcomes (PROs) as part of benefit-risk assessment for new drug approvals is increasing. Lefamulin is the first intravenous (IV) and oral pleuromutilin antibiotic for treatment of adults with community-acquired bacterial pneumonia (CABP). Assessment of health-related quality of life (HRQoL) was prospectively incorporated in its CABP trials (Lefamulin Evaluation Against Pneumonia [LEAP] 1 and 2) via the 12-Item Short-Form Survey (SF-12), a widely used PRO that measures general health status in 8 domains. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ofid/ofaa209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314585PMC

Hospital admissions for community-acquired, ventilator-associated and nonventilator hospital-acquired pneumonia in COPD patients in Spain (2016-2017).

Eur J Intern Med 2020 Jun 29. Epub 2020 Jun 29.

Preventive Medicine and Public Health Teaching and Research Unit. Health Sciences Faculty. Rey Juan Carlos University. Alcorcón. Madrid, 28922, Spain.

Background: To examine the incidence, characteristics and outcomes of community-acquired pneumonia (CAP), ventilator-associated pneumonia (VAP) and nonventilator hospital-acquired pneumonia (NV-HAP) in patients with or without COPD; compare in-hospital outcomes; and identify factors associated with in-hospital mortality (IHM) for pneumonia.

Methods: We carried out a retrospective observational study using the hospital discharge records from 2016-17 of the Spanish National Health System. Propensity score matching was used for data analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejim.2020.06.028DOI Listing

COVID-19 Is Distinct From SARS-CoV-2-Negative Community-Acquired Pneumonia.

Front Cell Infect Microbiol 2020 16;10:322. Epub 2020 Jun 16.

The Geriatric Respiratory Department of Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.

Corona virus disease (COVID-19) is an infectious respiratory disease that has spread rapidly across the world. Many studies have already evaluated the clinical features of COVID-19, but how it compares with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-negative community-acquired pneumonia (SN-CAP) is still unclear. Moreover, COVID-19 mortality is correlated with disease severity, but indicators for severity grading have not been specified. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fcimb.2020.00322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309449PMC

Detection of several carbapenems resistant and virulence genes in classical and hyper-virulent strains of Klebsiella pneumoniae isolated from hospitalized neonates and adults in Khartoum.

BMC Res Notes 2020 Jul 1;13(1):312. Epub 2020 Jul 1.

Biochemistry Department, Faculty of Sciences, King Abdulaziz University, Jeddah, 21452, Saudi Arabia.

Objective: Klebsiella pneumoniae (K. pneumoniae) involves both community-acquired and nosocomial infections. It is responsible for a wide variety of infections, including infections of the urinary tract, pneumonia, bacteremia, meningitis, wound infection and purulent abscesses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13104-020-05157-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328261PMC

Clinical Profile of Covid-19 Infected Patients Admitted in a Tertiary Care Hospital in North India.

J Assoc Physicians India 2020 May;68(5):13-17

SMS Medical College and Attached Group of Hospital, Jaipur, Rajasthan.

Background: The novel coronavirus (Covid-19) continues to wreck havoc across China, European countries, USA and now seems to gain a strong foothold in India. The aim of this report is to describe the clinical profiles of these Covid-19 infected patients admitted in Sawai Mansingh Hospital(S.M. Read More

View Article

Download full-text PDF

Source

Etiology of Community-Acquired Pneumonia Requiring Hospital Admission in Adults with and Without Cancers: A Single-Center Retrospective Study in China.

Infect Drug Resist 2020 8;13:1607-1617. Epub 2020 Jun 8.

Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Air Force Medical University, Xi'an, People's Republic of China.

Background: The etiology and distribution of community-acquired pneumonia (CAP) vary periodically and geographically. The clinical evaluation of CAP among patients with cancers remains unknown.

Patients And Methods: This retrospective hospital-based study on adult CAP was conducted in Tang Du Hospital, China, from September 2018 to August 2019. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/IDR.S251564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294101PMC

Incidence and Risk Factors for Severe Pneumonia in Children Hospitalized with Pneumonia in Ujjain, India.

Int J Environ Res Public Health 2020 Jun 27;17(13). Epub 2020 Jun 27.

Department of Pediatrics, Ruxmaniben Deepchand Gardi Medical College, Ujjain 456006, Madhya Pradesh, India.

Childhood pneumonia is a major public health problem. The aim of this prospective hospital-based study is to determine the incidence and risk factors for community-acquired severe pneumonia in children in Ujjain, India. The study includes 270 children, 161 (60%) boys and 109 (40%) girls, aged between 2 months and 5 years with World Health Organization defined and radiologically confirmed severe pneumonia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijerph17134637DOI Listing

Bacterial and fungal coinfection among hospitalised patients with COVID-19: A retrospective cohort study in a UK secondary care setting.

Clin Microbiol Infect 2020 Jun 27. Epub 2020 Jun 27.

Chelsea and Westminster NHS Foundation Trust, 369 Fulham Road, London, SW10 9NH. UK; North West London Pathology, Imperial College Healthcare NHS Trust, Fulham Palace Road. London. W6 8RF. UK; National Institute for Health Research Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Imperial College London, Hammersmith Campus, Du Cane Road, London. W12 0NN. UK.

Objectives: We investigate the incidence of bacterial and fungal co-infection of hospitalised patients with confirmed SARS-CoV-2 in this retrospective observational study across two London hospitals during the first UK wave of COVID-19.

Methods: A retrospective case-series of hospitalised patients with confirmed SARS-CoV-2 by PCR was analysed across two acute NHS hospitals (February 20-April 20; each isolate reviewed independently in parallel). This was contrasted to a control group of influenza positive patients admitted during 2019/20 flu season. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cmi.2020.06.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320692PMC

Stress ulcer prophylaxis versus placebo-a blinded randomized control trial to evaluate the safety of two strategies in critically ill infants with congenital heart disease (SUPPRESS-CHD).

Trials 2020 Jun 29;21(1):590. Epub 2020 Jun 29.

Harvard Medical School, Boston, MA, USA.

Background: Critically ill infants with congenital heart disease (CHD) are often prescribed stress ulcer prophylaxis (SUP) to prevent upper gastrointestinal bleeding, despite the low incidence of stress ulcers and limited data on the safety and efficacy of SUP in infants. Recently, SUP has been associated with an increased incidence of hospital-acquired infections, community-acquired pneumonia, and necrotizing enterocolitis. The objective of this pilot study is to investigate the feasibility of performing a randomized controlled trial to assess the safety and efficacy of withholding SUP in infants with congenital heart disease admitted to the cardiac intensive care unit. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13063-020-04513-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322718PMC

Alterations in Fecal Fungal Microbiome of Patients With COVID-19 During Time of Hospitalization until Discharge.

Gastroenterology 2020 Jun 24. Epub 2020 Jun 24.

Center for Gut Microbiota Research, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China; State Key Laboratory for digestive disease, Institute of Digestive Disease, Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Shatin, Hong Kong, China; Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China. Electronic address:

Backgroud & Aims: SARS-CoV-2 infects intestinal cells, and might affect the intestinal microbiota. We investigated changes in the fecal fungal microbiomes (mycobiome) of patients with SARS-CoV-2 infection during hospitalization and upon recovery.

Methods: We performed deep shotgun metagenomic sequencing analysis of fecal samples from 30 patients with COVID-19 in Hong Kong, from February 5 through May 12, 2020. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.gastro.2020.06.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318920PMC

[Surfactant proteins A and D: role in the pathogenesis of community-acquired pneumonia and possible predictive perspectives].

Ter Arkh 2020 Apr 27;92(3):109-115. Epub 2020 Apr 27.

Research Institute of Therapy and Preventive Medicine - branch of the Federal Research Center Institute of Cytology and Genetics.

Community-acquired pneumonia is one of the most common infectious diseases and remains one of the leading causes of death in this group of diseases. Studies of community-acquired pneumonia are extremely relevant for modern clinical practice. One of the important role in the pathogenesis of bacterial, viral, fungal invasion in the system of a human lung system belongs to the pulmonary surfactant, in particular, its proteins SP-A and SP-D. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.26442/00403660.2020.03.000275DOI Listing

[Fatal severe community-acquired pneumonia: risk factors, clinical characteristics and medical errors of hospital patients].

Ter Arkh 2020 Apr 27;92(3):42-49. Epub 2020 Apr 27.

Kazan (Volga Region) Federal University.

Community-acquired pneumonia (CAP) is the most common disease and potentially life-threatening infection in the worldwide. In the Nizhny Novgorod region, no analysis of the causes of mortality and medical errors of severe CAP patients.

Aim: To analyze the patients structure who died severe CAP in hospitals of the Nizhny Novgorod region, to identify the leading risk factors, to assess the clinical characteristics of fatal severe CAP and medical errors according to medical records of patients from 20152016. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.26442/00403660.2020.03.000538DOI Listing

[Comparative analysis of the strength of the respiratory muscles in community-acquired pneumonia with different severity of endogenous intoxication].

Ter Arkh 2020 Apr 27;92(3):19-24. Epub 2020 Apr 27.

Far Eastern Federal University.

Aim: To assess the strength of the respiratory muscles in patients with community-acquired pneumonia (CAP) with varying severity of endogenous intoxication.

Materials And Methods: In the hospital, 78 men aged 1826 years with CAP were examined. СAP was diagnosed in 56 (72%) patients, severe CAP in 22 (28%). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.26442/00403660.2020.03.000372DOI Listing

[Etiology of severe community - acquired pneumonia in adults: results of the first Russian multicenter study].

Ter Arkh 2020 Jan 15;92(1):36-42. Epub 2020 Jan 15.

M.K. Ammosov Federal North-Eastern University.

Aim: to study the etiology of severe community - acquired pneumonia (SCAP) in adults in Russian Federation. SCAP is distinguished by high mortality and socio - economic burden. Both etiology and antimicrobial resistance are essential for appropriate antibiotic choice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.26442/00403660.2020.01.000491DOI Listing
January 2020

[Features of central hemodynamics in patients with community - acquired pneumonia depending on the course of the disease and cardiovascular comorbidity].

Ter Arkh 2019 Dec 15;91(12):29-34. Epub 2019 Dec 15.

Vvedenskaya City Clinical Hospital.

Aim: The study of intracardiac hemodynamics and blood flow in the pulmonary circuit in patients with community - acquired pneumonia, depending on the presence of concomitant pathology of the cardiovascular system and the severity of the pathological process.

Materials And Methods: In 43 patients with community - acquired pneumonia (22 men, 21 women, mean age 67±17 years), the functional state of pulmonary - cardiac hemodynamics was assessed by echodoplerography. All subjects were divided into 2 groups: 1st group - 25 patients with community - acquired pneumonia (mean age 49±18 years) without concomitant pathology of the cardiovascular system and 2nd group - 18 patients with community - acquired pneumonia (mean age 70. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.26442/00403660.2019.12.000441DOI Listing
December 2019

Dual Antibiotic Therapy for Outpatient Management of Community-acquired Pneumonia?

Arch Bronconeumol 2020 Jun 23. Epub 2020 Jun 23.

University Institute in Primary Care Research Jordi Gol, Via Roma Health Centre, Barcelona, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arbres.2020.05.016DOI Listing

Community-acquired pneumonia caused by methicillin-resistant Staphylococcus aureus in a Chinese adult: A case report.

Medicine (Baltimore) 2020 Jun;99(26):e20914

Department of Respiratory Medicine.

Rationale: Methicillin-resistant Staphylococcus aureus (MRSA) has been established as an important cause of severe community-acquired pneumonia (CAP) with very high mortality. Panton-Valentine leukocidin (PVL) producing MRSA has been reported to be associated with necrotizing pneumonia and worse outcome. The incidence of community-acquired MRSA (CA-MRSA) pneumonia is very low, as only a few CA-MRSA pneumonia cases were reported in the last few years. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000020914DOI Listing

Primary pulmonary extranodal natural killer/T-cell lymphoma (ENKTL), nasal type: Two case reports and literature review.

Medicine (Baltimore) 2020 Jun;99(26):e20822

Department of Cardio-Thoracic Surgery, Shenzhen University General Hospital.

Introduction: Extranodal natural killer/T-cell lymphoma (ENKTL) - nasal type is an aggressive form of malignant non-Hodgkin lymphoma with a very poor prognosis. Especially primary pulmonary ENKTL is a relatively rare form of non-Hodgkin lymphoma. Until now, the prevalence of primary pulmonary ENKTL is unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000020822DOI Listing

miR-146a is a pivotal regulator of neutrophil extracellular trap formation promoting thrombosis.

Haematologica 2020 Jun 25. Epub 2020 Jun 25.

Centro regional de Hemodonación;

Neutrophil extracellular traps (NETs) induce a procoagulant response linking inflammation and thrombosis. Low levels of miR-146a, a brake of inflammatory response, are involved in higher risk for cardiovascular events, but the mechanisms explaining how miR-146a exerts its function remain largely undefined. The aim of this study was to explore the impact of miR-146a deficiency in NETosis both, in sterile and non-sterile models in vivo, and to inquire into the underlying mechanism. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3324/haematol.2019.240226DOI Listing

Clinical spectrum, etiology and outcome of infectious disease emergencies in adult diabetic patients in northern India.

Diabetes Metab Syndr 2020 Jun 12;14(5):921-925. Epub 2020 Jun 12.

Department of Medical Microbiology, PGIMER, Chandigarh, India. Electronic address:

Background And Aims: The patients with diabetes mellitus (DM) have an increased incidence of both common and unusual infections. Despite an increasing prevalence of DM in India, local data on the epidemiology and clinical spectrum of associated infections are lacking. We aimed to investigate the spectrum, etiology, and outcome of infectious disorders in adult patients with DM admitted in a medical emergency. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.dsx.2020.06.004DOI Listing

Concordance of early and late endpoints for community-acquired bacterial pneumonia trials.

Clin Infect Dis 2020 Jun 25. Epub 2020 Jun 25.

Office of Infectious Diseases, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD.

Background: While there are ongoing regulatory convergence efforts, differences remain in primary endpoints recommended for community-acquired bacterial pneumonia (CABP) trials. The US Food and Drug Administration recommends assessing CABP symptom resolution at an early time point (3-5 days after randomization). Other regulatory agencies recommend assessing overall clinical response at a later time point (5-10 days after therapy ends). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/cid/ciaa860DOI Listing

Understanding Early and Late Endpoints in Registrational Trials of Community-acquired Bacterial Pneumonia.

Authors:
George H Talbot

Clin Infect Dis 2020 Jun 25. Epub 2020 Jun 25.

Talbot Advisors LLC, Anna Maria, FL USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/cid/ciaa853DOI Listing

Characterization of the Inflammatory Response to Severe COVID-19 Illness.

Am J Respir Crit Care Med 2020 Jun 25. Epub 2020 Jun 25.

RCSI, Dublin, Ireland.

Rationale: Coronavirus disease 2019 (COVID-19) is a global threat to health. Its inflammatory characteristics are incompletely understood.

Objectives: To define the cytokine profile of COVID-19, and to identify evidence of immunometabolic alterations in those with severe illness. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1164/rccm.202005-1583OCDOI Listing

Population pharmacokinetics and dose optimization of ceftriaxone for children with community-acquired pneumonia.

Eur J Clin Pharmacol 2020 Jun 25. Epub 2020 Jun 25.

Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, No. 44, Wenhua West Road, Jinan, Shandong Province, China.

Purpose: To assess ceftriaxone population pharmacokinetics in a large pediatric population and describe the proper dose for establishing an optimized antibiotic regimen.

Methods: From pediatric patients using ceftriaxone, blood samples were obtained and the concentration was measured using high-performance liquid chromatography ultraviolet detection. The NONMEM software program was used for population pharmacokinetic analysis, for which data from 99 pediatric patients (2 to 12 years old) was collected and 175 blood concentrations were obtained. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00228-020-02939-4DOI Listing

Value of Blood Cultures in the Management of Children Hospitalized with Community-Acquired Pneumonia.

Cureus 2020 May 21;12(5):e8222. Epub 2020 May 21.

Pediatrics, State University of New York Downstate Medical Center, New York, USA.

Background and objectives Current guidelines for the management of community-acquired pneumonia (CAP) in children recommend obtaining a blood culture for children with moderate to severe pneumonia; yet, there is no guidance to assess the severity of the disease. Thus, a blood culture is obtained for the majority of children admitted with CAP, regardless of the severity of their symptoms. The study was designed to investigate and identify the prevalence of bacteremia in pediatric patients hospitalized with CAP and to evaluate the clinical and laboratory variables associated with bacteremia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.8222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306671PMC

Prevalence and clinical significance of common respiratory pathogens in the upper respiratory tract of children with community-acquired pneumonia in Zunyi, China.

Pediatr Pulmonol 2020 Jun 24. Epub 2020 Jun 24.

Department of Laboratory Medicine, The Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi City), Zunyi, Guizhou, P. R. China.

Purpose: To estimate the prevalence of common respiratory pathogens among children with community acquired pneumonia (CAP) in Zunyi City, Guizhou, China, and to assess whether the presence of common respiratory pathogens in patients is associated with disease severity.

Patients And Methods: This retrospective study assessed the prevalence of common respiratory viruses and bacteria in the upper respiratory tract of among infants and children aged 1 month to 5 years hospitalized with radiologically confirmed CAP between April 2017 and March 2018. Direct immunofluorescence assay and bacterial culture were used to identify viruses and bacteria in the upper airway specimens, respectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ppul.24922DOI Listing