11,650 results match your criteria Pneumonia Community-Acquired


[Experience of application of the PCR for identification of the causative agent of community acquired pneumonia in the military.]

Klin Lab Diagn 2018 ;63(10):641-645

«1586 Military Clinical Hospital» of the Ministry of Defense of the Russian Federation, 603105, Nizhniy Novgorod, Russian Federation.

Samples of sputum, blood, bronchoalveolar lavage, swabs from the oropharynx from 255 military personnel undergoing in-patient treatment with an x-ray confirmed diagnosis of community-acquired pneumonia (CAP) were examined by polymerase chain reaction (PCR). The comparison group was included 270 healthy recruits. The detection of S. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18821/0869-2084-2018-63-10-641-645DOI Listing
January 2018
4 Reads

Association of the Swiss Diagnosis-Related Group Reimbursement System With Length of Stay, Mortality, and Readmission Rates in Hospitalized Adult Patients.

JAMA Netw Open 2019 Feb 1;2(2):e188332. Epub 2019 Feb 1.

Division of General Internal and Emergency Medicine, University Department of Medicine, Kantonsspital Aarau, Aarau, Switzerland.

Importance: In 2012, hospital reimbursement in Switzerland changed from a fee-for-service per diem system to a diagnosis-related group (SwissDRG) system. Whether this change in reimbursement is associated with harmful implications for quality of care and patient outcomes remains unclear.

Objective: To examine the association of the SwissDRG implementation with length of hospital stay (LOS), in-hospital mortality, and 30-day readmission rates in the overall adult inpatient population and stratified by 5 individual diagnoses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamanetworkopen.2018.8332DOI Listing
February 2019

Pharmaceutical Approval Update.

P T 2019 Jan;44(2):42-44

Arikayce (amikacin liposome inhalation suspension) for complex lung disease; Xofluza (baloxavir marboxil) for acute uncomplicated influenza; and Nuzyra (omadacycline) for community-acquired bacterial pneumonia and/or acute bacterial skin and skin structure infections. Read More

View Article

Download full-text PDF

Source
January 2019

Retrospective study of pneumonia due to Panton-Valentine leukocidin-producing Staphylococcus aureus in Reunion.

Med Mal Infect 2019 Feb 11. Epub 2019 Feb 11.

Centre René Labusquière, (Institut de Médecine tropicale), Université Victor Segalen, 33000 Bordeaux, France; Service de réanimation polyvalente, centre hospitalier universitaire, site Felix Guyon, allée des Topazes, CS11021, 97400 Saint-Denis, Reunion.

Objective: Panton-Valentine leukocidin-producing Staphylococcus aureus necrotizing pneumonia is an unusual cause of community-acquired pneumonia, although associated with a high case fatality. This infection mainly affects young individuals, without any history, and is most often preceded by flu-like symptoms.

Method: We focused on patients presenting with Staphylococcus aureus necrotizing pneumonia in Reunion (Indian Ocean) admitted to the emergency department. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.medmal.2019.01.010DOI Listing
February 2019

PES Pathogens in Severe Community-Acquired Pneumonia.

Microorganisms 2019 Feb 12;7(2). Epub 2019 Feb 12.

Department of Pneumology, Hospital Clinic of Barcelona-Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona (UB)-SGR 911-Ciber de Enfermedades Respiratorias (Ciberes), 08036 Barcelona, Spain.

Worldwide, there is growing concern about the burden of pneumonia. Severe community-acquired pneumonia (CAP) is frequently complicated by pulmonary and extra-pulmonary complications, including sepsis, septic shock, acute respiratory distress syndrome, and acute cardiac events, resulting in significantly increased intensive care admission rates and mortality rates. (Pneumococcus) remains the most common causative pathogen in CAP. Read More

View Article

Download full-text PDF

Source
http://www.mdpi.com/2076-2607/7/2/49
Publisher Site
http://dx.doi.org/10.3390/microorganisms7020049DOI Listing
February 2019
1 Read

Boerhaave Syndrome in an Elderly Man.

Eur J Case Rep Intern Med 2018 24;5(10):000944. Epub 2018 Oct 24.

Internal Medicine Department, Centro Hospitalar de São João, Porto, Portugal.

Boerhaave syndrome is rare, has an non-specific clinical presentation and most commonly develops after persistent vomiting. Septic shock dominates the clinical picture as a result of extensive infection of the mediastinum and pleural and abdominal cavities. The current management of Boerhaave syndrome includes conservative, endoscopic and surgical treatments. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12890/2018_000944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346888PMC
October 2018

In vitro activities of antimicrobial peptides and ceragenins against Legionella pneumophila.

J Antibiot (Tokyo) 2019 Feb 12. Epub 2019 Feb 12.

Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Istanbul University, Beyazit, Istanbul, 34116, Turkey.

Legionella pneumophila is a waterborne intracellular pathogenic bacterium, the most frequent cause of human legionellosis and a relatively common cause of community-acquired and nosocomial pneumonia. Some legionellosis outbreaks are related to the presence of biofilms, which provide a reservoir for L. pneumophila strains. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41429-019-0148-1DOI Listing
February 2019

Chlamydia pneumoniae enhances Interleukin 8 (IL-8) production with reduced azithromycin sensitivity under hypoxia.

APMIS 2019 Mar;127(3):131-138

Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University, Sapporo, Japan.

Obligate intracellular bacterium Chlamydia pneumoniae causes respiratory tract infections such as community-acquired pneumonia. During infection, C. pneumoniae induces inflammatory responses in host cells and the oxygen concentration at the infection sites subsequently decreases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apm.12924DOI Listing
March 2019
1 Read

Erratum to rhinovirus is associated with severe adult community-acquired pneumonia in China.

J Thorac Dis 2018 Dec;10(12):E861

Department of Respiratory and Critical Care Medicine, Peking University People's Hospital, Beijing 100044, China.

[This corrects the article DOI: 10.21037/jtd.2017. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/jtd.2018.11.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344775PMC
December 2018
1 Read

Outpatient Antimicrobial Stewardship: Targets for Community-Acquired Pneumonia.

Clin Ther 2019 Feb 7. Epub 2019 Feb 7.

Department of Pharmacy, Veteran Affairs Western New York Healthcare System, Buffalo, NY, USA. Electronic address:

Purpose: Community-acquired pneumonia (CAP) is one of the leading causes of death in the United States. The primary objective of this study was to determine the prevalence of appropriate diagnosis and treatment of outpatients treated for CAP. Knowledge of problems with CAP treatment can be helpful in developing stewardship initiatives to improve care of outpatients with CAP. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clinthera.2019.01.007DOI Listing
February 2019
1 Read

Risk of community-acquired pneumonia in older adults with sarcopenia of a hospital from Callao, Peru 2010-2015.

Arch Gerontol Geriatr 2019 Jan 29;82:100-105. Epub 2019 Jan 29.

Universidad de San Martin de Porres, Facultad de Medicina Humana, Centro de investigación del evejecimiento (CIEN), Lima, Peru; Universidad Científica del Sur, Lima, Peru.

Introduction: Sarcopenia is a geriatric syndrome characterized by loss of muscle mass and strength. The prevalence in people between 60-70 years is about 5-13% and in adults over 80 years, between 11-50% in the USA. Sarcopenia increases the risk of mortality and nosocomial infections. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01674943193000
Publisher Site
http://dx.doi.org/10.1016/j.archger.2019.01.008DOI Listing
January 2019
8 Reads

Evaluation of the prevalence of Legionella pneumophila in Iranian clinical samples: A systematic review and meta-analysis.

Microb Pathog 2019 Feb 7;129:93-98. Epub 2019 Feb 7.

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical of Sciences, Mashhad, Iran; Neurogenic Inflammation Research Center, Mashhad University of Medical of Sciences, Mashhad, Iran; School of Pharmacy, Mashhad University of Medical of Sciences, Mashhad, Iran. Electronic address:

Background: Legionella pneumophila is the main cause for community-acquired pneumonia especially in hospital environments. In this systematic review and meta-analysis, we evaluated the prevalence of L. pneumophila in clinical samples obtained from Iranian patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.micpath.2019.02.008DOI Listing
February 2019
2 Reads

A case report of community-acquired Pseudomonas aeruginosa pneumonia complicated with MODS in a previously healthy patient and related literature review.

BMC Infect Dis 2019 Feb 8;19(1):130. Epub 2019 Feb 8.

Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, Republic of China.

Background: Pseudomonas aeruginosa is an unusual pathogen in community-acquired pneumonia, especially in previously healthy adults, but often indicates poor prognosis.

Case Presentation: We report a previously healthy patient who developed severe community-acquired pneumonia (CAP) caused by P. aeruginosa. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12879-019-3765-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368713PMC
February 2019
2 Reads

Clinical prognostic significance of serum high mobility group box-1 protein in patients with community-acquired pneumonia.

J Int Med Res 2019 Feb 7:300060518819381. Epub 2019 Feb 7.

1 Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.

Objective: To investigate the relationship between serum high mobility group box-1 protein (HMGB-1) levels and prognosis in patients with community-acquired pneumonia (CAP).

Methods: This prospective study included 35 patients who attended our hospital from January 2016 to December 2016. Pneumonia severity was defined by pneumonia severity index (PSI). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0300060518819381DOI Listing
February 2019
1 Read

Computed tomography scan contribution to the diagnosis of community-acquired pneumonia.

Curr Opin Pulm Med 2019 Feb 5. Epub 2019 Feb 5.

Department of Internal Medicine, Rehabilitation and Geriatrics, Internal Medicine and Rehabilitation Unit, Geneva University Hospitals and University of Geneva, Geneva, Switzerland.

Purpose Of Review: Pneumonia is a frequent disease mainly affecting older and multimorbid patients. Symptoms and signs lack sensitivity and specificity, and chest X-ray has poor accuracy. Hence, an initial diagnosis of pneumonia has limited predictive value for the presence of pneumonia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MCP.0000000000000567DOI Listing
February 2019
1 Read

[Successful extracorporeal membrane oxygenation (ECMO) treatment in Legionella pneumonia].

Orv Hetil 2019 Feb;160(6):235-240

Központi Aneszteziológiai és Intenzív Betegellátó Osztály, Dél-pesti Centrumkórház - Országos Hematológiai és Infektológiai Intézet Budapest.

The mortality of severe ARDS is almost 60%. Ventilation-associated lung-injury can be avoided by low-pressure, low-volume ventilation. Potential use of ECMO in case of refractory hypoxemia beside modern ventilatory therapy can be considered. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1556/650.2019.31285DOI Listing
February 2019
1 Read

Radiologic Diagnosis and Hospitalization among Children with Severe Community Acquired Pneumonia: A Prospective Cohort Study.

Biomed Res Int 2019 9;2019:6202405. Epub 2019 Jan 9.

Hawassa University, College of Medicine and Health Sciences, Department of Pediatrics and Child health, Hawassa, P.O. Box 1560, Ethiopia.

Objectives: This study was designed to assess the role of chest radiography for the diagnosis of pneumonia and assess the association of clinical characteristics with radiologic findings and predictors of hospitalization among children with severe community acquired pneumonia.

Methods: A prospective study was conducted on 122 children between ages of 3 month and 14 years admitted to pediatric emergency unit with diagnosis of severe pneumonia from September 1 to November 30, 2017. Eligible children were subjected to chest radiography which was read by two senior radiologists independently ( and ). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2019/6202405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343177PMC
January 2019
1 Read

Unilateral hearing loss in a 94-year-old patient.

Age Ageing 2019 Feb 6. Epub 2019 Feb 6.

Department of Geratology, John Radcliffe Hospital Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

A case report of a 94-year-old, previously well male patient who presented with fever thought to be caused by community acquired pneumonia, new unilateral hearing loss and reduced consciousness. Despite antibiotic treatment he continued to deteriorate. Brain imaging with computer tomography and magnetic resonance imaging revealed a left otomastoiditis with osteomyelitis of the skull base, associated with an adjacent subdural empyema. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ageing/afz003DOI Listing
February 2019
2 Reads

Omadacycline for Community-Acquired Bacterial Pneumonia.

N Engl J Med 2019 02;380(6):517-527

From City Clinical Hospital #6, Zaporizhzhia, Ukraine (R.S.); Sf. Pantelimon Clinical Emergency Hospital, Bucharest, Romania (M.P.); Lung Center of the Philippines, Manila (J.R.G.); Lakeview Hospital, Benoni, South Africa (I.M.); EMMS, Nazareth Hospital, Nazareth, and Faculty of Medicine in the Galilee, Bar-Ilan University, Safed - both in Israel (W.N.); the Department of Internal Medicine and Pharmacology, Andrzej Frycz Modrzewski Krakow University, Krakow, Poland (A. Madej); AD Stats Consulting, Guerneville, CA (A.F.D.); and Paratek Pharmaceuticals, King of Prussia, PA (C.K., L.G.-R., J.N.S., A. Manley, P.B.E., E.T., P.C.M., E.L.).

Background: Omadacycline, a new once-daily aminomethylcycline antibiotic agent that can be administered intravenously or orally, reaches high concentrations in pulmonary tissues and is active against common pathogens that cause community-acquired bacterial pneumonia.

Methods: In a double-blind trial, we randomly assigned (in a 1:1 ratio) adults with community-acquired bacterial pneumonia (Pneumonia Severity Index risk class II, III, or IV) to receive omadacycline (100 mg intravenously every 12 hours for two doses, then 100 mg intravenously every 24 hours), or moxifloxacin (400 mg intravenously every 24 hours). A transition to oral omadacycline (300 mg every 24 hours) or moxifloxacin (400 mg every 24 hours), respectively, was allowed after 3 days; the total treatment duration was 7 to 14 days. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMoa1800201DOI Listing
February 2019
3 Reads

[New cephalosporins].

Rev Chilena Infectol 2018 ;35(5):465-475

Departamento de Medicina Interna, Facultad de Medicina, Universidad Nacional de Colombia, Bogotá, Colombia.

Bacterial resistance has increased in Latin America and the world, making research and creation of new antimicrobials capable of eradicating resistant microorganisms essential. A review of new cephalosporins and their combinations with a beta-lactamase inhibitor was conducted, collecting data on the spectrum, pharmacokinetic and pharmacodynamic profile and clinical studies of the current indications for ceftaroline, and the combinations ceftazidime with avibactam and ceftolozane with tazobactam. The first one has activity against methicillin-resistant Staphylococcus aureus and coagulase negative Staphylococcus (SCoN) and against penicillin-resistant Streptococcus pneumoniae, therefore approved for use in community-acquired pneumonia and acute bacterial skin and skin structure infections. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4067/s0716-10182018000500465DOI Listing
January 2018
1 Read

Efficacy and Safety of IV-to-Oral Lefamulin, a Pleuromutilin Antibiotic, for Treatment of Community-Acquired Bacterial Pneumonia: The Phase 3 LEAP 1 Trial.

Clin Infect Dis 2019 Feb 4. Epub 2019 Feb 4.

Nabriva Therapeutics US, Inc., King of Prussia, PA, USA.

Background: Lefamulin, a pleuromutilin antibiotic, is active against pathogens commonly causing community-acquired bacterial pneumonia (CABP). The Lefamulin Evaluation Against Pneumonia (LEAP 1) study (NCT02559310) was a global noninferiority trial to evaluate the efficacy and safety of lefamulin for the treatment of CABP.

Methods: In this double-blind study, adults with CABP of Pneumonia Outcomes Research Team risk class ≥III were randomized 1:1 to receive lefamulin 150 mg intravenously (IV) q12h or moxifloxacin 400 mg IV q24h. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/cid/ciz090DOI Listing
February 2019
2 Reads

[Clinical application evaluation and revision suggestions of clinical practice guideline on traditional Chinese medicine therapy alone or combined with antibiotics for community acquired pneumonia].

Zhongguo Zhong Yao Za Zhi 2018 Dec;43(24):4759-4764

Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.

To clarify the clinical application of the group standard (T/CACM 1035-2017) of the Chinese Society of Traditional Chinese Medicine (TCM), the clinical practice guideline on traditional chinese medicine therapy alone or combined with community acquired pneumonia, and to understand the clinical applicability of the Guideline. The clinical workers trained in terms of the Guideline in hospitals at all levels in China were selected as the research objects. A total of 494 questionnaires on application evaluation and 511 questionnaires on applicability evaluation were collected to construct the database of the post-effect evaluation of the Guideline. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.19540/j.cnki.cjcmm.20181009.006DOI Listing
December 2018
1 Read

Long-term Association of 13-Valent Pneumococcal Conjugate Vaccine Implementation With Rates of Community-Acquired Pneumonia in Children.

JAMA Pediatr 2019 Feb 4. Epub 2019 Feb 4.

Association Clinique et Thérapeutique Infantile du Val-de-Marne, St Maur-des-Fossés, France.

Importance: In several countries, 5 years after 13-valent pneumococcal conjugate vaccine (PCV13) implementation, serotype replacement has been reported for invasive pneumococcal disease, which raises concerns about the long-term outcome of PCV13 implementation. The long-term effect of vaccination on community-acquired pneumonia (CAP) remains unknown.

Objective: To assess the long-term outcome of PCV13 implementation on CAP in children. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamapediatrics.2018.5273DOI Listing
February 2019
1 Read

The use of multiplex PCR for the detection of atypical pathogens in Egyptian children with CAP: a high rate of in early infancy.

J Egypt Public Health Assoc 2019 18;94(1). Epub 2019 Jan 18.

2Department of Clinical Pathology, Faculty of Medicine, Cairo University, 2 Atteia Abd El Hadi St., El Maadi, Cairo, 11562 Egypt.

Background: Atypical pathogen infections played an important role in community-acquired pneumonia (CAP) in children. Pathogen-specific clinical symptoms are often lacking, and it is difficult to detect atypical pathogens by culture methods. The use of multiplex polymerase chain reaction (PCR) methods enables testing for many pathogens simultaneously in a single analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s42506-018-0003-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338716PMC
January 2019
6 Reads

The prevalence of complications of pneumonia among adults admitted to a tertiary care center in Riyadh from 2010-2017.

Ann Saudi Med 2019 Jan-Feb;39(1):29-36

Sara Ibrahim Alshahwan, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia,, College of of Medicine, King Saud bin Abdulaziz University for Health Sciences,, PO Box 102729 Riyadh 11685, Saudi Arabia, T: +966-55-235-6533, Alshahwan258@ ksau-hs.edu.sa, ORCID: http://orcid. org/0000-0002-3789-1682.

Background: Pneumonia, the commonest lower respiratory tract infection, can result in respiratory and non-respiratory complications. Few studies have reported on the prevalence of many complications.

Objectives: Identify the prevalence of 18 complications of pneumonia and compare complication rates by age group and type of pneu. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5144/0256-4947.2019.29DOI Listing
February 2019
2 Reads

Bacteriologic Profile and Susceptibility Pattern of Mechanically - Ventilated Pediatric Patients with Pneumonia.

J Glob Antimicrob Resist 2019 Jan 30. Epub 2019 Jan 30.

Department of Pediatrics, Alexandria University, Faculty of Medicine, El-Shatby Hospital, Alexandria, Egypt. Electronic address:

Purpose: Therapy of severe pneumonia is very challenging in view of the current widespread bacterial resistance to many antibiotics especially extended spectrum ß-lactams, carbapenems, and anti-pseudomonal drugs. The current study aimed at assessing antimicrobial sensitivity pattern and optimization of the antibiotic stewardship program applied in a university affiliated pediatric intensive care unit (PICU).

Subjects And Methods: This prospective cohort study included all patients aged 1 month to 12 years, admitted to the PICU with severe pneumonia episodes indicated for mechanical ventilation, and were followed up and investigated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jgar.2019.01.028DOI Listing
January 2019
1 Read

[Analysis on distribution and drug resistance of pathogen caused community-onset bloodstream infection].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2019 Jan;31(1):67-72

Department of Emergency-Critical Care Medicine, Huashan North Hospital, Fudan University, Shanghai 201907, China. Corresponding author: Xia Zhijie, Email:

Objective: To investigate the distribution and drug resistance of pathogen caused community-onset bloodstream infection (COBSI) in patients of affiliated hospital of university, and to provide evidence for the clinical therapy.

Methods: The clinical data of patients with COBSI in emergency department admitted to Huashan North Hospital Affiliated to Fudan University from January 2014 to December 2017 were collected, and the distribution and drug resistance of pathogen were retrospectively analyzed. The patients were divided into community-acquired bloodstream infection (CABSI) group and health care-associated bloodstream infection (HCABSI) group according to clinical diagnosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.issn.2095-4352.2019.01.014DOI Listing
January 2019
2 Reads

Challenges in severe community-acquired pneumonia: a point-of-view review.

Intensive Care Med 2019 Feb 31;45(2):159-171. Epub 2019 Jan 31.

Pulmonary and Critical Care Division, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Purpose: Severe community-acquired pneumonia (SCAP) is still associated with substantial morbidity and mortality. In this point-of-view review paper, a group of experts discuss the main controversies in SCAP: the role of severity scores to guide patient settings of care and empiric antibiotic therapy; the emergence of pathogens outside the core microorganisms of CAP; viral SCAP; the best empirical treatment; septic shock as the most lethal complication; and the need for new antibiotics.

Methods: For all topics, the authors describe current controversies and evidence and provide recommendations and suggestions for future research. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00134-019-05519-yDOI Listing
February 2019

Scored minor criteria for severe community-acquired pneumonia predicted better.

Respir Res 2019 Jan 31;20(1):22. Epub 2019 Jan 31.

Guangzhou Institute of Respiratory Diseases (State Key Laboratory of Respiratory Diseases), First Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510120, Guangdong, China.

Background: Infectious Disease Society of America/American Thoracic Society (IDSA/ATS) minor criteria for severe community-acquired pneumonia (CAP) are of unequal weight in predicting mortality, but the major problem associated with IDSA/ATS minor criteria might be a lack of consideration of weight in prediction in clinical practice. Would awarding different points to the presences of the minor criteria improve the accuracy of the scoring system? It is warranted to explore this intriguing hypothesis.

Methods: A total of 1230 CAP patients were recruited to a retrospective cohort study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12931-019-0991-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357403PMC
January 2019
1 Read

Modifiable risk factors for community-acquired pneumonia in children under five years of age in resource-poor settings: a case-control study.

Trop Med Int Health 2019 Jan 31. Epub 2019 Jan 31.

Kilimanjaro Clinical Research Institute, Moshi, Tanzania.

Objective: Despite the availability of vaccines and antibiotics, pneumonia remains the leading cause of mortality among children under five years of age. The objective of this study was to identify modifiable risk factors for community-acquired pneumonia (CAP) in children under five years of age in a vaccinated population.

Methods: A case-control study was conducted between January and December 2017. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/tmi.13211
Publisher Site
http://dx.doi.org/10.1111/tmi.13211DOI Listing
January 2019
4 Reads

Predictors of community-acquired pneumonia in patients with acute decompensated heart failure: the results of the analysis of the hospital sample EPOHA-D-CHF.

Ter Arkh 2018 Apr;90(4):35-41

Nizhny Novgorod State Medical Academy, Ministry of Health of Russia, Nizhny Novgorod, Russia.

Aim: Identify the most significant predictors of community-acquired pneumonia and their im-pact on the risk of this disease in patients with ADHF.

Materials And Methods: The analysis of the hospital sample of patients (n=852) with ADHF. In 16. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.26442/terarkh201890435-41DOI Listing
April 2018
1 Read

Complete Genome Sequence of the Methicillin-Resistant Staphylococcus aureus Strain JMUB3031, Isolated from a Patient with Fatal Community-Acquired Pneumonia.

Microbiol Resour Announc 2019 Jan 24;8(4). Epub 2019 Jan 24.

Division of Bacteriology, Department of Infection and Immunity, School of Medicine, Jichi Medical University, Shimotsuke, Japan.

Severe community-acquired pneumonia (CAP) caused by methicillin-resistant Staphylococcus aureus (MRSA) is relatively rare and is usually associated with rapid progression to death. Here, we report the complete genome sequence of the MRSA strain JMUB3031, which was isolated from a patient with fatal CAP. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/MRA.01652-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346209PMC
January 2019
2 Reads

Diagnostic accuracy of chest ultrasound in patients with pneumonia in the intensive care unit: A single-hospital study.

Health Sci Rep 2019 Jan 26;2(1):e102. Epub 2018 Nov 26.

Respiratory Unit Ahmadi Hospital Ahmadi Kuwait.

Background And Aims: Chest radiography (CXR) and computerized tomography (CT) scan are the preferred methods for lung imaging in diagnosing pneumonia in the intensive care unit, in spite of their limitations. The aim of this study was to assess the performance of bedside lung ultrasound examination by a critical care physician, compared with CXR and chest CT, in the diagnosis of acute pneumonia in the ICU.

Materials And Methods: This was an observational, prospective, single-center study conducted in the intensive care unit of Ahmadi General Hospital. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hsr2.102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346984PMC
January 2019
1 Read

Impact of a smartphone app on prescriber adherence to antibiotic guidelines in adult patients with community acquired pneumonia or urinary tract infections.

PLoS One 2019 29;14(1):e0211157. Epub 2019 Jan 29.

National Institute for Health Innovation, University of Auckland, Glen Innes, Auckland, New Zealand.

Background: Mobile phone apps have been shown to enhance guideline adherence by prescribers, but have not been widely evaluated for their impact on guideline adherence by prescribers caring for inpatients with infections.

Objectives: To determine whether providing the Auckland City Hospital (ACH) antibiotic guidelines in a mobile phone app increased guideline adherence by prescribers caring for inpatients with community acquired pneumonia (CAP) or urinary tract infections (UTIs).

Methods: We audited antibiotic prescribing during the first 24 hours after hospital admission in adults admitted during a baseline and an intervention period to determine whether provision of the app increased the level of guideline adherence. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211157PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350960PMC
January 2019
1 Read

Short-course versus long-course antibiotic treatment for community-acquired pneumonia: a literature review.

Basic Clin Pharmacol Toxicol 2019 Jan 29. Epub 2019 Jan 29.

Section of General Practice and Research Unit for General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.

Background: It is well known that antibiotic use is the main driver for the increasing problems with resistant bacteria. Consequently, some countries have recommended shortening the duration of antibiotic treatment of community-acquired pneumonia (CAP). The aim of this study was to investigate if the effectiveness of a short-course antibiotic is comparable to a longer course of antibiotics in adults with CAP and to assess if the duration of an antibiotic course influences the development of resistant bacteria. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bcpt.13205DOI Listing
January 2019
2 Reads

Performance of the CHADS-VASc score in predicting new onset atrial fibrillation during hospitalization for community-acquired pneumonia.

Eur J Intern Med 2019 Jan 25. Epub 2019 Jan 25.

Cardiomyopathy Unit, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.

Background: Cardiovascular events are common during hospitalization for community-acquired pneumonia (CAP), with new onset atrial fibrillation (NOAF) being the second most relevant complication. In this study, we aimed to investigate the role of CHADS-VASc score in predicting NOAF during hospitalization for CAP.

Methods: Patients admitted for CAP were prospectively assessed using CHADS-VASc. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejim.2019.01.012DOI Listing
January 2019
1 Read

A review of innate and adaptive immunity to coccidioidomycosis.

Med Mycol 2019 Feb;57(Supplement_1):S85-S92

Infectious Diseases Section, VA Healthcare San Diego, California, USA.

Coccidioidomycosis is a human fungal disease cause by inhalation of aerosol spores produced by Coccidioides posadasii or Coccidioides immitis. This disease is a common cause of community-acquired pneumonia in the endemic areas of the Southwestern United States. It also can present as a life-threatening disease as the fungal cells disseminate to skin, bone, and central nervous system. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/mmy/myy146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347076PMC
February 2019
3 Reads

Macrolides in Critically Ill Patients with Middle East Respiratory Syndrome.

Int J Infect Dis 2019 Jan 25. Epub 2019 Jan 25.

International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia. Electronic address:

Objectives: Macrolides have been reported to be associated with improved outcomes in patients with viral pneumonia related to influenza and other viruses, possibly because of their immune-modulatory effects. Macrolides have frequently been used in patients with Middle East Respiratory Syndrome (MERS). This study investigated the association of macrolides with 90-day mortality and MERS coronavirus (CoV) RNA clearance in critically ill patients with MERS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijid.2019.01.041DOI Listing
January 2019
4 Reads
2.330 Impact Factor

Principles and Practice of Antibiotic Stewardship in the ICU.

Chest 2019 Jan 25. Epub 2019 Jan 25.

Pulmonary and Critical Care, Northwestern University Feinberg School of Medicine, 240 E. Huron Street, McGaw M-300, Chicago, IL 60611.

In the face of emerging drug resistant pathogens and a decrease in the development of new antimicrobial agents, antibiotic stewardship should be practiced in all critical care units. Antibiotic stewardship should be a core competency of all critical care practitioners in conjunction with a formal Antibiotic Stewardship Program (ASP). Prospective audit and feedback, and antibiotic time outs are effective components of an ASP in the ICU. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00123692193006
Publisher Site
http://dx.doi.org/10.1016/j.chest.2019.01.013DOI Listing
January 2019
3 Reads

Role of Probiotics in Pneumonia in Children: A Short-Term Pilot Project.

Front Microbiol 2018 9;9:3261. Epub 2019 Jan 9.

Department of Gastroenterology, Affiliated Beijing Children's Hospital, Capital Medical University, Beijing, China.

is one of the most common pathogens causing community-acquired pneumonia in children. pneumonia (MPP) can be successfully treated with azithromycin; however, antibiotic-associated diarrhea (AAD) is a common adverse effect. Increasing evidence suggests that some probiotics may prevent the development of AAD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmicb.2018.03261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334620PMC
January 2019
2 Reads

Prognostic significance of malnutrition for long-term mortality in community-acquired pneumonia: a propensity score matched analysis.

Korean J Intern Med 2019 Jan 29. Epub 2019 Jan 29.

Department of Pulmonology and Critical Care Medicine, Pusan National University Yangsan Hospital, Yangsan, Korea.

Background/aims: The impact of malnutrition on the outcome of hospitalized adults with community-acquired pneumonia (CAP) has not been fully investigated. This study evaluated the prevalence and prognostic significance of malnutrition in a Korean population with CAP.

Methods: In total, 198 patients with CAP from November 2014 to September 2015 were analyzed retrospectively. Read More

View Article

Download full-text PDF

Source
http://kjim.org/journal/view.php?doi=10.3904/kjim.2018.037
Publisher Site
http://dx.doi.org/10.3904/kjim.2018.037DOI Listing
January 2019
4 Reads

Macrolide prescription in Dutch children: compliance with guidelines.

Eur J Clin Microbiol Infect Dis 2019 Jan 24. Epub 2019 Jan 24.

Department of Clinical Pharmacy, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands.

For reasons of antibiotic resistance and side effects, macrolides should be prescribed with care in the pediatric population. We evaluated the adherence to Dutch guidelines of macrolide prescription in children and estimated the risk of Mycoplasma pneumoniae-associated pneumonia based on Fischer's decision tree. In this retrospective study, we included children aged 0-18 years who were treated with azithromycin or clarithromycin for pulmonary disease in four settings from general practice to hospital ward for (1) the prescriptions not in accordance with the guideline of the Dutch Association of Pediatrics and (2) the risk of M. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10096-019-03473-7DOI Listing
January 2019
1 Read

Positively interacting strains that co-circulate within a network structured population induce cycling epidemics of Mycoplasma pneumoniae.

Sci Rep 2019 Jan 24;9(1):541. Epub 2019 Jan 24.

Centre for Infectious Disease Surveillance and Control, Public Health England, London, UK.

Mycoplasma pneumoniae (MP) is considered a common cause of pneumonia, causing about 15-20% of adult community-acquired pneumonia (CAP) and up to 40% of cases in children. It has often been observed that MP epidemics last approximately 1-2 years and occur every 3-7 years, with the dominant strains alternating between epidemics. However, the underlying mechanism by which these cycles and changes in the dominant strains occur remains unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-018-36325-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345813PMC
January 2019
2 Reads

[Epidemiological and clinical analysis of community-acquired Mycoplasma pneumonia in children from a Spanish population, 2010-2015].

An Pediatr (Barc) 2019 Jan 21. Epub 2019 Jan 21.

Servicio de Pediatría, Hospital General Universitario, Valencia, España.

Introduction And Objectives: Mycoplasma pneumoniae (MP) is one of the most common etiological agents of community-acquired pneumonia (CAP) in children. We aimed to describe the clinical and epidemiological characteristics, treatment and outcome of children diagnosed with community-acquired MP pneumonia (CAMP) in a tertiary hospital in Valencia, Spain.

Material And Methods: Medical records of children <14 years with CAMP were retrospectively reviewed from January 2010 to December 2015. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.anpedi.2018.07.016DOI Listing
January 2019
2 Reads

Bacterial regulation of macrophage bacterial recognition receptors in COPD are differentially modified by budesonide and fluticasone propionate.

PLoS One 2019 24;14(1):e0207675. Epub 2019 Jan 24.

Veterans Health Administration, Veterans Affairs Western New York Healthcare System at Buffalo, Division of Pulmonary, Critical Care and Sleep Medicine, Buffalo, New York, United States of America.

Rationale: Patients with COPD have an increased risk for community-acquired pneumonia, which is further increased by inhaled corticosteroids.

Objective: To assess effects of the corticosteroids, budesonide and fluticasone propionate, on macrophage bacterial responses in COPD.

Methods: Monocyte-derived macrophages (MDMs) generated from blood monocytes from 10 non-smoker controls (NoS), 20 smokers without COPD (Sm), and 40 subjects with moderate to severe COPD (21 ex-smokers (COPD-ES) and 19 current smokers (COPD-S)) were pre-treated with budesonide or fluticasone (10 nM-1 μM) and challenged with live non-typeable Haemophilus influenzae (NTHI) or Streptococcus pneumoniae (SP). Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207675PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345465PMC
January 2019
3 Reads

Aspiration pneumonia and pneumonitis: a spectrum of infectious/noninfectious diseases affecting the lung.

Curr Opin Infect Dis 2019 Jan 22. Epub 2019 Jan 22.

Section of Pulmonary and Critical Care Medicine, Intermountain Medical Center, Murray.

Purpose Of Review: Our purpose is to describe aspiration pneumonia/pneumonitis as a spectrum of infectious/noninfectious diseases affecting the lung. We summarize diagnosis, risk factors, treatment, and strategies for prevention of aspiration.

Recent Findings: Aspiration is present in normal individuals, and disease manifestation depends on the chemical characteristics, frequency, and volume of inoculum. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/QCO.0000000000000524DOI Listing
January 2019
2 Reads

[Status of antibiotic use in hospitalized children with community-acquired pneumonia in multiple regions of China].

Zhongguo Dang Dai Er Ke Za Zhi 2019 Jan;21(1):11-17

First Clinical Medical Institute, Liaoning University of Traditional Chinese Medicine, Shenyang 110032, China.

Objective: To investigate the use of antibiotics in children with community-acquired pneumonia (CAP) in multiple regions of China, and to provide a reference for CAP standard treatment and rational antibiotic use in children.

Methods: The medical data of 1 383 children with CAP who were hospitalized in the department of pediatrics in 10 grade A tertiary hospitals from 9 cities between April 14, 2014 and January 1, 2016 were reviewed, to analyze the status of antibiotic use in hospitalized children in North China, Northeast China, East China, and South China.

Results: The overall rate of antibiotic use in children with CAP was 89. Read More

View Article

Download full-text PDF

Source
January 2019
3 Reads

The use of bedside echocardiography for measuring cardiac index and systemic vascular resistance in pediatric patients with septic shock.

Rev Bras Ter Intensiva 2018 Oct-Dec;30(4):460-470

Department of Pediatrics, Faculty of Medicine, Cairo University - Cairo, Egypt.

Objective: Follow-up of cardiac index and systemic vascular resistance index by bedside echocardiography until resuscitation.

Methods: A set of hemodynamic parameters was obtained, including cardiac output, stroke volume, cardiac index, systemic vascular resistance index, velocity time integral, myocardial performance index, capillary refill time, and heart rate at 0 hours after fluid boluses before the start of inotropes, and followed up after 6 hours and 24 hours.

Results: Included were 45 patients with community-acquired septic shock. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5935/0103-507X.20180067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334480PMC
April 2018
2 Reads

Lung Ultrasound Combined With Procalcitonin for a Diagnosis of Ventilator-Associated Pneumonia.

Respir Care 2019 Jan 22. Epub 2019 Jan 22.

Department of Critical Care Medicine, Ningbo Medical Center Lihuili Eastern Hospital, Ningbo, China.

Background: Lung ultrasound is a valuable imaging tool in the diagnosis of community-acquired pneumonia. However, its diagnostic accuracy in ventilator-associated pneumonia (VAP) has not been fully investigated. The aim of this study was to evaluate the diagnostic performance of the combination of a lung ultrasound with procalcitonin (PCT) in mechanically ventilated subjects with symptoms suggestive of pneumonia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4187/respcare.06377DOI Listing
January 2019
2 Reads

Antibacterial Activity of Lefamulin Against Pathogens Most Commonly Causing Community-Acquired Bacterial Pneumonia: SENTRY Antimicrobial Surveillance Program (2015-2016).

Antimicrob Agents Chemother 2019 Jan 22. Epub 2019 Jan 22.

JMI Laboratories, North Liberty, IA, USA.

Lefamulin, the first semisynthetic pleuromutilin antibacterial for intravenous and oral treatment of community-acquired bacterial pneumonia (CABP), and comparators were evaluated for activity against a global collection of pathogens commonly causing CABP (n=8595) from the 2015-2016 SENTRY Antimicrobial Surveillance Program. Lefamulin was highly active against pathogens commonly including multidrug resistant and extensively drug resistant strains (MIC for total and resistant subsets, 0.06/0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.02161-18DOI Listing
January 2019
2 Reads