14,595 results match your criteria Pneumonia Community-Acquired

Biomarkers for iron metabolism among patients hospitalized with community-acquired pneumonia caused by infection with SARS-CoV-2, bacteria, and influenza.

APMIS 2022 Jun 25. Epub 2022 Jun 25.

Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark.

Background: Ferritin, the central iron storage protein, has attracted attention as a biomarker of severe COVID-19. Few studies have investigated regulators of iron metabolism in the context of COVID-19. The aim was to evaluate biomarkers for iron metabolism in the acute phase response to community-acquired pneumonia (CAP) caused by SARS-CoV-2 compared to CAP caused by bacteria or influenza virus in hospitalized patients. Read More

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Shorter versus longer durations of antibiotic treatment for patients with community-acquired pneumonia: a protocol for a systematic review and meta-analysis.

BMJ Open 2022 Jun 24;12(6):e062428. Epub 2022 Jun 24.

Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada

Introduction: Community-acquired pneumonia (CAP), frequently encountered in both outpatient and inpatient settings, is the leading cause of infectious disease-related mortality. While equipoise regarding the optimal duration of antimicrobial therapy to treat CAP remains, recent studies suggest shorter durations of therapy may achieve optimal outcomes. We have therefore planned a systematic review and meta-analysis evaluating the impact of shorter versus longer durations of antibiotic therapy for patients with CAP. Read More

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Early differentiated CD28 CD27 T lymphocytes as a biomarker for short and long-term outcomes in older patients with pneumonia.

J Leukoc Biol 2022 Jun 23. Epub 2022 Jun 23.

Immunology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.

This study tested the hypothesis that a more senescent immune system would predict a worse outcome in older patients hospitalized for community-acquired pneumonia (CAP). CAP has long been responsible for high rates of mortality and readmissions among older people. Although immunosenescence is a key factor in the increased susceptibility to infections, there are no related biomarkers currently available in clinical practice. Read More

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Respiratory virus testing and clinical outcomes among children hospitalized with pneumonia.

J Hosp Med 2022 Jun 23. Epub 2022 Jun 23.

Division of Emergency Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.

Background: Despite the increased availability of diagnostic tests for respiratory viruses, their clinical utility for children with community-acquired pneumonia (CAP) remains uncertain.

Objective: To identify patterns of respiratory virus testing across children's hospitals prior to the COVID-19 pandemic and to determine whether hospital-level rates of viral testing were associated with clinical outcomes.

Design, Setting, And Participants: Multicenter retrospective cohort study of children hospitalized for CAP at 19 children's hospitals in the United States from 2010-2019. Read More

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Relationship between biomarkers and findings on low-dose computed tomography in hospitalised patients with acute exacerbation of COPD.

ERJ Open Res 2022 Apr 20;8(2). Epub 2022 Jun 20.

Dept Pulmonary Diseases, Northwest Hospital, Alkmaar, the Netherlands.

Background: Acute exacerbations of COPD (AECOPD) and community acquired pneumonia (CAP) often coexist. Although chest radiographs may differentiate between these diagnoses, chest radiography is known to underestimate the incidence of CAP in AECOPD. In this exploratory study, we prospectively investigated the incidence of infiltrative changes using low-dose computed tomography (LDCT). Read More

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A Case of Right Ventricular Thrombus in a Patient With Recent COVID-19 Infection.

Cureus 2022 May 19;14(5):e25150. Epub 2022 May 19.

Cardiology, Nicosia General Hospital, Nicosia, CYP.

Coronavirus disease 2019 (COVID-19) is a viral respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The respiratory system is the main target of the virus; however, apart from lung disease, a relatively large proportion of patients develop thrombosis as well. We present the case of a 19-year-old male who was admitted after contracting community-acquired right-sided pneumonia. Read More

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Magnetic Nanoclusters Increase the Sensitivity of Lateral Flow Immunoassays for Protein Detection: Application to Pneumolysin as a Biomarker for .

Nanomaterials (Basel) 2022 Jun 14;12(12). Epub 2022 Jun 14.

Department of Physics & IUTA, University of Oviedo, Campus de Viesques, 33203 Gijón, Spain.

Lateral flow immunoassays for detecting biomarkers in body fluids are simple, quick, inexpensive point-of-care tests widely used in disease surveillance, such as during the coronavirus disease 2019 (COVID-19) pandemic. Improvements in sensitivity would increase their utility in healthcare, food safety, and environmental control. Recently, biofunctional magnetic nanoclusters have been used to selectively label target proteins, which allows their detection and quantification with a magneto-inductive sensor. Read More

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Impact of establishing a respiratory high dependency unit for SCAP patients on the therapeutic effect, prognosis, and expenditure: a retrospective case-control study.

Qin Yalan Tong Jin

Sci Rep 2022 Jun 23;12(1):10703. Epub 2022 Jun 23.

Department of Respiratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, 76# Linjiang Road, Yuzhong district, Chongqing, 400010, China.

To explore the effects of establishing a high dependency unit (HDU) on the prognosis, outcome, and expenditure of patients with severe community-acquired pneumonia (SCAP). 108 SCAP patients were recruited from the respiratory intensive care unit (RICU) of the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. Of these, 87 qualified the study-selection criteria and were divided into HDU group (treated in HDU after discharge from RICU prior to transfer to normal unit) (n = 40) and normal group (not treated in the HDU) (n = 47). Read More

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A limited role for microbiological testing for childhood lower respiratory tract infections in primary care: managing diagnostic uncertainty by withholding antibiotics and watchful waiting.

Clin Microbiol Infect 2022 Jun 20. Epub 2022 Jun 20.

Division of Infectious Diseases and Hospital Epidemiology, University Children's Hospital Zurich, Steinwiesstrasse 75, CH-8032 Zurich, Switzerland. Electronic address:

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The Incidence of Venous Thromboembolism in Critically Ill Patients with SARS-CoV-2 Infection Compared with Critically Ill Influenza and Community-Acquired Pneumonia Patients: A Retrospective Chart Review.

Med Sci (Basel) 2022 Jun 8;10(2). Epub 2022 Jun 8.

Multidisciplinary Intensive Care Research Organization (MICRO), St James's Hospital, D08 NHY1 Dublin, Ireland.

The rate of venous thromboembolism in COVID-19 patients has been reported to be 30% (deep vein thrombosis 20% and pulmonary embolism 18%). This has been shown to be higher in COVID-19 patients admitted to the ICU. Prophylactic anticoagulation may be sufficient at ward level, but not in intensive care. Read More

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Alveolar-Arterial Gradient Is an Early Marker to Predict Severe Pneumonia in COVID-19 Patients.

Infect Dis Rep 2022 Jun 15;14(3):470-478. Epub 2022 Jun 15.

Infectious Disease Unit, ARNAS Civico-Di Cristina, Piazza Leotta 5, 90100 Palermo, Italy.

Background: One of the main challenges in the management of COVID-19 patients is to early assess and stratify them according to their risk of developing severe pneumonia. The alveolar-arterial oxygen gradient (D(A-a)O) is defined as the difference between the alveolar and arteriolar concentration of oxygen, an accurate index of the ventilatory function. The aim of this study is to evaluate D(A-a)O as a marker for predicting severe pneumonia in COVID-19 patients, in comparison to the PaO/FiO. Read More

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Prevalence, characteristics, and predictors of healthcare workers with COVID-19 infection in an urban district in Malaysia.

Pan Afr Med J 2022 24;41:243. Epub 2022 Mar 24.

Department of Community Health, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaakob Latif, Cheras, Kuala Lumpur, 56000, Malaysia.

Introduction: healthcare workers (HCWs) are at high risk of acquiring COVID-19 occupational transmission and subsequently, exposing patients and others. This study aimed to determine the prevalence and examine the characteristics and predictors of HCWs with COVID-19 infection in a Malaysian district.

Methods: this is a cross-sectional study of HCWs working at Cheras District Health Office, with COVID-19 infection from 1 January to 31 October 2021. Read More

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Target capture sequencing reveals a monoclonal outbreak of respiratory syncytial virus B infections among adult hematologic patients.

Antimicrob Resist Infect Control 2022 Jun 21;11(1):88. Epub 2022 Jun 21.

Institute for Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.

Background: Respiratory syncytial virus (RSV) causes community-acquired respiratory tract infections during winter. However, outbreaks in hospitals also occur repeatedly. In particular, patients with hematologic malignancies are at an increased risk for a severe and potentially fatal course of RSV infection. Read More

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Epidemiology of community-acquired pneumonia among hospitalised children in Indonesia: a multicentre, prospective study.

BMJ Open 2022 Jun 21;12(6):e057957. Epub 2022 Jun 21.

National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.

Objective: To identify aetiologies of childhood community-acquired pneumonia (CAP) based on a comprehensive diagnostic approach.

Design: 'Partnerships for Enhanced Engagement in Research-Pneumonia in Paediatrics (PEER-PePPeS)' study was an observational prospective cohort study conducted from July 2017 to September 2019.

Setting: Government referral teaching hospitals and satellite sites in three cities in Indonesia: Semarang, Yogyakarta and Tangerang. Read More

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[Comparative analysis of clinical features between severe coronavirus disease 2019 and severe community acquired pneumonia].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2022 May;34(5):485-491

Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine (originally named "Shanghai First People's Hospital"), Shanghai 201620, China.

Objective: To compare and analyze the clinical features of patients with severe coronavirus disease 2019 (sCOVID-19) and severe community acquired pneumonia (sCAP) who meet the diagnostic criteria for severe pneumonia of the Infectious Diseases Society of America/American Thoracic Society (IDSA/ATS).

Methods: A retrospective comparative analysis of the clinical records of 116 patients with sCOVID-19 admitted to the department of critical care medicine of Wuhan Third Hospital from January 1, 2020 to March 31, 2020 and 135 patients with sCAP admitted to the department of critical care medicine of Shanghai First People's Hospital from January 1, 2010 to December 31, 2017 was conducted. The basic information, diagnosis and comorbidities, laboratory data, etiology and imaging results, treatment, prognosis and outcome of the patients were collected. Read More

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Age- and sex-related differences in community-acquired pneumonia at presentation to the emergency department: a retrospective cohort study.

Eur J Emerg Med 2022 Apr 8. Epub 2022 Apr 8.

Department of Internal and Emergency Medicine, Buergerspital Solothurn, Solothurn.

Background And Importance: Because of its associated high morbidity and mortality, early identification and treatment of community-acquired pneumonia (CAP) are essential.

Objectives: To investigate age- and sex-related differences in clinical symptoms, radiologic findings and outcomes in patients presenting to the emergency department (ED) with CAP.

Design: Retrospective cohort study. Read More

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Predicting Mortality and Use of RISC Scoring System in Hospitalized Under-Five Children Due to WHO Defined Severe Community Acquired Pneumonia.

J Trop Pediatr 2022 Jun;68(4)

Department of Pediatrics, Dr. R.M.L. Institute of Medical Sciences, Lucknow, India.

Background: Pneumonia acquired in the community is a leading cause of hospitalization and death in under-five children. Predicting mortality in children remains a challenge. There is a need of consolidated scoring system to predict mortality in under-five children in developing nations. Read More

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Hey, Community-Acquired Pneumonia Is Back on the Map!

Susan E Hamblin

Crit Care Med 2022 Jul 13;50(7):1153-1155. Epub 2022 Jun 13.

Lipscomb University College of Pharmacy and Health Sciences, Nashville, TN.

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Hospitalization costs of adult community-acquired pneumonia in England.

J Med Econ 2022 Jun 21:1-22. Epub 2022 Jun 21.

Vaccines Medical Affairs, Pfizer Ltd, UK, Walton Oaks, Tadworth, Surrey, UK.

Objective: Accurate and up-to-date figures of the cost of community-acquired pneumonia (CAP) hospitalization are needed to understand the associated economic burden for public health decision makers. Recent estimates are lacking, and previously published estimates differ markedly. Our objective was to estimate the current mean cost to the NHS for adult CAP hospitalization. Read More

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Low-dose methylprednisolone treatment in critically ill patients with severe community-acquired pneumonia.

Intensive Care Med 2022 May 13. Epub 2022 May 13.

Office of Research and Development, Department of Veterans Affairs, Baltimore, USA.

Purpose: Severe community-acquired pneumonia (CAP) requiring intensive care unit admission is associated with significant acute and long-term morbidity and mortality. We hypothesized that downregulation of systemic and pulmonary inflammation with prolonged low-dose methylprednisolone treatment would accelerate pneumonia resolution and improve clinical outcomes.

Methods: This double-blind, randomized, placebo-controlled clinical trial recruited adult patients within 72-96 h of hospital presentation. Read More

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Age, Pulse, Urea, and Albumin Score: A Tool for Predicting the Short-Term and Long-Term Outcomes of Community-Acquired Pneumonia Patients With Diabetes.

Front Endocrinol (Lausanne) 2022 1;13:882977. Epub 2022 Jun 1.

Department of Endocrinology, The First Hospital of Qinhuangdao, Qinhuangdao, China.

Objective: The predictive performances of CURB-65 and pneumonia severity index (PSI) were poor in patients with diabetes. This study aimed to develop a tool for predicting the short-term and long-term outcomes of CAP in patients with diabetes.

Methods: A retrospective study was conducted on 531 CAP patients with type 2 diabetes. Read More

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Weaker Response to XueBiJing Treatment in Severe Community-Acquired Pneumonia Patients With Higher Body Mass Index or Hyperglycemia: A Analysis of a Randomized Controlled Trial.

Front Pharmacol 2022 3;13:755536. Epub 2022 Jun 3.

Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.

Overweight and hyperglycemia might result in poor prognosis in patients with severe community-acquired pneumonia (SCAP). XueBiJing treatment could significantly improve the outcomes of patients with SCAP. We investigated the efficacy of XueBiJing injection in patients with SCAP stratified by body mass index (BMI) and fasting blood glucose (FBG). Read More

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Acute Pancreatitis: An Unusual Extrapulmonary Manifestation of Mycoplasma pneumoniae.

Cureus 2022 May 16;14(5):e25052. Epub 2022 May 16.

Internal Medicine, Northwest General Hospital, Peshawar, PAK.

is a respiratory pathogen responsible for community-acquired atypical pneumonia. Apart from respiratory manifestations, other system involvement has also been reported. We present a case of interstitial pneumonia and a concurrent episode of acute pancreatitis in a young female who presented with fever, cough, vomiting, and epigastric pain. Read More

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The contribution of hospital-acquired infections to the COVID-19 epidemic in England in the first half of 2020.

BMC Infect Dis 2022 Jun 18;22(1):556. Epub 2022 Jun 18.

Healthcare Associated Infections and Antimicrobial Resistance Division, National Infection Service, Public Health England, Colindale, London, UK.

Background: SARS-CoV-2 is known to transmit in hospital settings, but the contribution of infections acquired in hospitals to the epidemic at a national scale is unknown.

Methods: We used comprehensive national English datasets to determine the number of COVID-19 patients with identified hospital-acquired infections (with symptom onset > 7 days after admission and before discharge) in acute English hospitals up to August 2020. As patients may leave the hospital prior to detection of infection or have rapid symptom onset, we combined measures of the length of stay and the incubation period distribution to estimate how many hospital-acquired infections may have been missed. Read More

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Astodrimer sodium antiviral nasal spray for reducing respiratory infections is safe and well tolerated in a randomized controlled trial.

Sci Rep 2022 Jun 17;12(1):10210. Epub 2022 Jun 17.

Starpharma Pty Ltd, 4-6 Southampton Crescent, Abbotsford, VIC, 3067, Australia.

Astodrimer sodium is a dendrimer molecule with antiviral and virucidal activity against SARS-CoV-2 and other respiratory viruses in vitro, and has previously been shown to be safe and well tolerated, and not systemically absorbed, when applied to the vaginal mucosa. To investigate its potential utility as a topical antiviral, astodrimer sodium has been reformulated for application to the nasal mucosa to help reduce viral load before or after exposure to respiratory infection. The current investigation assessed the safety, tolerability and absorption of astodrimer sodium 1% antiviral nasal spray. Read More

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Do we need blood culture stewardship programs? A quality control study and survey to assess the appropriateness of blood culture collection and the knowledge and attitudes among physicians in Swiss hospitals.

Eur J Intern Med 2022 Jun 14. Epub 2022 Jun 14.

Division of Internal Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland; Department of Clinical Research, University of Basel, Schanzenstrasse 55, 4056 Basel, Switzerland. Electronic address:

Background: Guidance for blood culture (BC) collection is limited. Inappropriate BC collection may be associated with potentially harmful consequences for the patient such as unnecessary laboratory testing, treatment and additional costs. The aim of the study was to assess the appropriateness of BC collection and related knowledge and attitude of precribers. Read More

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Delafloxacin: A Review in Community-Acquired Pneumonia.

Drugs 2022 Jun 16;82(8):913-923. Epub 2022 Jun 16.

Springer Nature, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand.

Delafloxacin (BAXDELA in the USA; Quofenix in the EU) is an anionic fluoroquinolone antibacterial that is approved for the treatment of community-acquired pneumonia (CAP) and acute bacterial skin and skin structure infections in adults. Delafloxacin demonstrated in vitro activity against Gram-positive and Gram-negative pathogens, including drug-resistant isolates. In a phase III trial in adults with CAP, delafloxacin was noninferior to moxifloxacin when assessed against FDA- and EMA-defined primary endpoints, with both fluoroquinolones achieving high treatment success rates. Read More

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Prevalence of Empiric Antibacterial Therapy, Community-Acquired Bacterial Superinfection, and Antibiotic-associated Adverse Reactions among Patients with COVID-19 Pneumonia Admitted in Makati Medical Center from March 2020 to March 2021.

Infect Chemother 2022 Jun 10. Epub 2022 Jun 10.

Section of Infectious Diseases, Department of Medicine, Makati Medical Center, Makati, Philippines.

Introduction: Coronavirus disease 2019 (COVID-19) is caused by the novel coronavirus which was first discovered in Wuhan, China. Being a viral illness, antibacterial agents theoretically have no role in patients with pure COVID-19 infection. However, like any viral illness, concomitant bacterial infection may occur. Read More

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Unmasking Myocardial Dysfunction in Patients Hospitalized for Community-Acquired Pneumonia Using a 4-Chamber 3-Dimensional Volume/Strain Analysis.

J Digit Imaging 2022 Jun 15. Epub 2022 Jun 15.

The Lydia and Carol Kittner, Lea and Benjamin Davidai Division of Cardiovascular Medicine and Surgery, Padeh Poriya Medical Center, Lower Galilee, Tiberias, Israel.

Lower respiratory infection was reported as the most common fatal infectious disease. Community-acquired pneumonia (CAP) and myocardial injury are associated; yet, true prevalence of myocardial injury is probably underestimated. We assessed the rate and severity of myocardial dysfunction in patients with CAP. Read More

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Clin-Star corner: What's new at the interface of geriatrics, infectious diseases, and antimicrobial stewardship.

J Am Geriatr Soc 2022 Jun 15. Epub 2022 Jun 15.

Division of Geriatric and Palliative Care Medicine, Department of Internal Medicine, Michigan Medicine, Ann Arbor, Michigan, USA.

Antibiotics are among the leading causes of adverse drug events in older adults. Short-course antibiotic therapy has been shown to work as well as the traditional longer durations for many types of infections. Antibiotic stewardship interventions including deprescribing strategies have shown a reduction in patient readmissions and mortality among older adults. Read More

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