13,692 results match your criteria Pneumonia Community-Acquired


Efficacy of Omadacycline Versus Moxifloxacin in the Treatment of Community-Acquired Bacterial Pneumonia by Disease Severity: Results From the OPTIC Study.

Open Forum Infect Dis 2021 Jun 18;8(6):ofab135. Epub 2021 Jun 18.

Paratek Pharmaceuticals, Inc., King of Prussia, Pennsylvania, USA.

Background: Severity/mortality risk scores and disease characteristics may assist in deciding whether patients with community-acquired bacterial pneumonia (CABP) require outpatient treatment or hospitalization. The phase 3 OPTIC (Omadacycline for Pneumonia Treatment In the Community) study enrolled patients with Pneumonia Outcomes Research Team (PORT) risk class II-IV. Omadacycline demonstrated noninferiority to moxifloxacin in adults with CABP, at early clinical response (ECR) and posttreatment evaluation (PTE). Read More

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Clinical Efficacy of Patients With Secondary Bacteremia Treated With Omadacycline: Results From Phase 3 Acute Bacterial Skin and Skin Structure Infections and Community-Acquired Bacterial Pneumonia Studies.

Open Forum Infect Dis 2021 Jun 18;8(6):ofab136. Epub 2021 Jun 18.

Paratek Pharmaceuticals Inc., King of Prussia, Philadelphia, USA.

In this post hoc analysis of the 63 patients with secondary bacteremia enrolled in the 3 omadacycline phase 3 studies of acute bacterial skin/skin structure infections (ABSSSI) and community-acquired bacterial pneumonia (CABP), we determined that omadacycline is a viable therapeutic option for appropriate patients with secondary bacteremia. Read More

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[COMMUNITY ACQUIRED KLEBSIELLA PNEUMONIAE LIVER ABSCESS - REPORT FROM ISRAEL].

Harefuah 2021 Jun;160(6):355-357

Internal Medicine Department F, Soroka Medical Center, Beer Sheva, Israel.

Background: Klebsiella pneumoniae is facultative anaerobic bacilli gram-negative bacteria. Klebsiella pneumoniae, often causes urinary tract infections and sometimes causes community acquired pneumonia. During the past two decades, a distinct syndrome of Klebsiella pneumoniae with a pyogenic liver abscess was noted. Read More

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Necrotizing pneumonia with bronchopleural fistula as an uncommon complication of pneumonia in children: a case report.

Radiol Case Rep 2021 Aug 8;16(8):2077-2080. Epub 2021 Jun 8.

Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.

Necrotizing pneumonia is an uncommon but severe complication of community acquired pneumonia characterized by the development of necrosis, liquefaction, and cavitation of the lung parenchyma. It occurs infrequently in children, ranging from 0.8% to 7% of community acquired pneumonia cases. Read More

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Bacterial and viral respiratory tract microbiota and host characteristics in adults with lower respiratory tract infections: a case-control study.

Clin Infect Dis 2021 Jun 22. Epub 2021 Jun 22.

Center for Experimental and Molecular Medicine (CEMM), Amsterdam University Medical Centers - Location AMC, University of Amsterdam, Amsterdam, The Netherlands.

Background: Viruses and bacteria from the nasopharynx are capable of causing community-acquired pneumonia (CAP), which can be difficult to diagnose. We aimed to investigate whether shifts in the composition of these nasopharyngeal microbial communities can be used as diagnostic biomarkers for CAP in adults.

Methods: We collected nasopharyngeal swabs from adult CAP patients and controls without infection in a prospective multicenter case-control study design. Read More

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A analysis of two Phase III trials showing efficacy and tolerability of ceftobiprole in East Asian patients.

Future Microbiol 2021 Jun 22. Epub 2021 Jun 22.

Basilea Pharmaceutica International Ltd., Basel, Switzerland.

To evaluate the efficacy and safety of ceftobiprole in patients from East Asia. A analysis was conducted of two randomized, double-blind, Phase III studies in patients with community- or hospital-acquired pneumonia. Findings for East Asian patients were consistent with the overall study populations. Read More

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The Role of Macrolides for the Management of Community-Acquired Pneumonia and Pneumonia by the Novel Coronavirus SARS-CoV-2 (COVID-19): A Position Paper by Four Medical Societies from Greece.

Infect Dis Ther 2021 Jun 16:1-15. Epub 2021 Jun 16.

1st Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

In light of the accumulating evidence for survival benefit coming from the use of macrolides for community-acquired pneumonia (CAP), a group of experts from the field of internal medicine and infectious diseases frame a position statement on the use of macrolides for the management of bacterial CAP and for infection by the novel coronavirus (COVID-19). The statement is framed taking into consideration existing publications and own research experience. The main content of this statement is that the combination of one β-lactam and a macrolide should be the first treatment of choice for patients with severe bacterial CAP. Read More

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Leveraging Physiologically-Based Pharmacokinetic (PBPK) Modeling and Experimental Data to Guide Dosing Modification of CYP3A-Mediated Drug-Drug Interactions (DDIs) in the Pediatric Population.

Drug Metab Dispos 2021 Jun 21. Epub 2021 Jun 21.

UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, United States

Solithromycin is a novel fluoroketolide antibiotic that is both a substrate and time-dependent inhibitor of cytochrome P450 (CYP) 3A. Solithromycin has demonstrated efficacy in adults with community-acquired bacterial pneumonia (CABP) and has also been investigated in pediatric patients. The objective of this study was to develop a framework for leveraging physiologically-based pharmacokinetic (PBPK) modeling to predict CYP3A-mediated drug-drug interaction (DDI) potential in the pediatric population using solithromycin as a case study. Read More

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In Vitro Activity of Nafithromycin (WCK 4873) against .

Antimicrob Agents Chemother 2021 Jun 21:AAC0058521. Epub 2021 Jun 21.

Department of Pediatrics, Division of Infectious Diseases, SUNY Downstate Medical Center, Brooklyn, New York, 11203, USA.

Nafithromycin (13 WCK 4873) is a novel lactone ketolide under clinical development as an orally administrated antibiotic for treatment of community acquired pneumonia (CAP) caused by , and methicillin susceptible .…. Read More

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co-infection with SARS-CoV-2: A case report.

Access Microbiol 2021 Mar 10;3(3):000212. Epub 2021 Mar 10.

Department of Onco-Anaesthesia and Palliative Medicine, All India Institute of Medical Sciences, New Delhi, India.

We report co-infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and in a patient with pneumonia in India. Atypical bacterial pathogens causing community-acquired pneumonia may share similar clinical presentations and radiographic features with SARS-CoV-2 making a thorough differential diagnosis essential. The co-infection of SARS-CoV-2 and is infrequently reported in the literature. Read More

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Analysis of Lymphocyte Subpopulations and Cytokines in COVID-19-Associated Pneumonia and Community-Acquired Pneumonia.

J Immunol Res 2021 9;2021:6657894. Epub 2021 Jun 9.

Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, Hubei, China.

Background: The 2019 novel coronavirus SARS-CoV-2 caused large outbreaks of COVID-19 worldwide. COVID-19 resembles community-acquired pneumonia (CAP). Our aim was to identify lymphocyte subpopulations to distinguish between COVID-19 and CAP. Read More

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Usefulness of β-lactam and macrolide combination therapy for treating community-acquired pneumonia patients hospitalized in the intensive care unit: Propensity score analysis of a prospective cohort study.

J Infect Chemother 2021 Jun 17. Epub 2021 Jun 17.

Department of Intensive Care, Ohara Healthcare Foundation, Kurashiki Central Hospital, Kurashiki, Okayama 710-8602, Japan. Electronic address:

Introduction: Whether β-lactam and macrolide combination therapy reduces mortality in severe community-acquired pneumonia (SCAP) patients hospitalized in the intensive care unit (ICU) is controversial. The aim of the present study was to evaluate the usefulness of β-lactam and macrolide combination therapy for SCAP patients hospitalized in the ICU.

Methods: A prospective, observational, cohort study of hospitalized pneumonia patients was performed. Read More

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Metagenomic Next-Generation Sequencing for Pathogenic Diagnosis and Antibiotic Management of Severe Community-Acquired Pneumonia in Immunocompromised Adults.

Front Cell Infect Microbiol 2021 1;11:661589. Epub 2021 Jun 1.

Capital Medical University China-Japan Friendship School of Clinical Medicine, Beijing, China.

Background: Metagenomic next-generation sequencing (mNGS) is a promising technique for pathogens diagnosis. However, application of mNGS in immunocompromised adults with severe community-acquired pneumonia (SCAP) is relatively limited.

Methods: We retrospectively reviewed 23 immunocompromised and 21 immunocompetent SCAP patients with mNGS detection from April 2019 to December 2019. Read More

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[SARS-COV-2 infection in patients with hematological malignancies and transplants].

Medicina (B Aires) 2021 ;81(3):396-400

Sección Infectología, Departamento de Medicina Interna, Centro de Educación Médica e Investigaciones Clínicas (CEMIC), Buenos Aires, Argentina.

SARS-CoV-2 infection in patients with hematological malignancies and hematopoietic stem cell transplants (HSCT) can be severe and with significant mortality. We carried out a prospective and observational study to describe the clinical and epidemiological characteristics and outcome of SARS-CoV-2 infection in patients with hematological malignancies and HSCT. Twenty adult patients were included with a median age of 58 years and a median Charlson score of 3. Read More

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The Role of Macrolides for the Management of Community-Acquired Pneumonia and Pneumonia by the Novel Coronavirus SARS-CoV-2 (COVID-19): A Position Paper by Four Medical Societies from Greece.

Infect Dis Ther 2021 Jun 16. Epub 2021 Jun 16.

1st Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

In light of the accumulating evidence for survival benefit coming from the use of macrolides for community-acquired pneumonia (CAP), a group of experts from the field of internal medicine and infectious diseases frame a position statement on the use of macrolides for the management of bacterial CAP and for infection by the novel coronavirus (COVID-19). The statement is framed taking into consideration existing publications and own research experience. The main content of this statement is that the combination of one β-lactam and a macrolide should be the first treatment of choice for patients with severe bacterial CAP. Read More

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Combined influence of practice guidelines and prospective audit and feedback stewardship on antimicrobial treatment of community-acquired pneumonia and empyema in children: 2012 to 2016.

Paediatr Child Health 2021 Jul 30;26(4):234-241. Epub 2020 Jun 30.

Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario.

Background: Aminopenicillins are recommended empiric therapy for community-acquired pneumonia (CAP). The aim of the study was to assess treatment over a 5-year period after CAP guideline publication and introduction of an antimicrobial stewardship program (ASP).

Methods: Using ICD-10 discharge codes for pneumonia, children less than 18 years admitted to the Children's Hospital of Eastern Ontario January 1, 2012 and December 31, 2016 were identified. Read More

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Diffuse alveolar haemorrhage secondary to in a vaping patient.

BMJ Case Rep 2021 Jun 15;14(6). Epub 2021 Jun 15.

Department of Cardiothoracic Surgery, Aspirus Wausau Hospital, Wausau, Wisconsin, USA.

Diffuse alveolar haemorrhage (DAH) is known to occur from several infectious and non-infectious aetiologies. Among the infectious aetiologies, , an organism known to cause community-acquired pneumonia, has not been reported in association with DAH prior to this case. On the other hand, vaping, an evolving epidemic concern, has been linked to various types of lung injury, including DAH. Read More

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Clinical characteristics and outcomes of community-acquired pneumonia in western Saudi Arabia: A four-year retrospective analysis of medical records.

J Infect Public Health 2021 May 27;14(7):960-966. Epub 2021 May 27.

Infection Prevention and Control, King Abdulaziz Medical City, Ministry of National Guard - Health Affairs, Riyadh, Saudi Arabia; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia; King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.

Background: Community-acquired pneumonia (CAP) is a significant cause of morbidity and mortality, especially for the elderly and people who suffer from chronic conditions. This study was conducted to assess the clinical and microbiological characteristics and disease outcomes associated with the occurrence of CAP.

Methods: This retrospective chart review was conducted at King Abdulaziz Medical City, Jeddah, Saudi Arabia. Read More

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Population-based incidence and mortality of community-acquired pneumonia in Germany.

PLoS One 2021 15;16(6):e0253118. Epub 2021 Jun 15.

Pfizer Deutschland GmbH, Berlin, Germany.

Background: Little information on the current burden of community-acquired pneumonia (CAP) in adults in Germany is available.

Methods: We conducted a retrospective cohort study using a representative healthcare claims database of approx. 4 million adults to estimate the incidence rates (IR) and associated mortality of CAP in 2015. Read More

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Approach to Identifying Causative Pathogens of Community-Acquired Pneumonia in Children Using Culture, Molecular, and Serology Tests.

Front Pediatr 2021 28;9:629318. Epub 2021 May 28.

National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.

Determining the causative pathogen(s) of community-acquired pneumonia (CAP) in children remains a challenge despite advances in diagnostic methods. Currently available guidelines generally recommend empiric antimicrobial therapy when the specific etiology is unknown. However, shifts in epidemiology, emergence of new pathogens, and increasing antimicrobial resistance underscore the importance of identifying causative pathogen(s). Read More

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BioFire FilmArray Pneumonia Panel for Severe Lower Respiratory Tract Infections: Subgroup Analysis of a Randomized Clinical Trial.

Infect Dis Ther 2021 Jun 13. Epub 2021 Jun 13.

4th Department of Internal Medicine, Medical School, ATTIKON University Hospital, National and Kapodistrian University of Athens, 1 Rimini Street, 124 62, Athens, Greece.

Introduction: The epidemiology of severe lower respiratory tract infections (LRTI) is constantly changing. We aimed to describe it using the BioFire FilmArray Pneumonia plus (PNplus) Panel.

Methods: In a sub-study of the PROGRESS trial, sputum samples of 90 patients with sepsis and LRTI were retrospectively studied. Read More

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Clinico-microbiological description and evaluation of rapid lateral flow immunoassay and PCR for detection of Burkholderia pseudomallei from patients hospitalized with sepsis and pneumonia: A twenty-one months study from Odisha, India.

Acta Trop 2021 Jun 9;221:105994. Epub 2021 Jun 9.

Department of Community and Family Medicine, AIIMS, Bhubaneswar, Odisha, India. Electronic address:

Establishing a diagnosis of melioidosis based on clinical grounds is difficult in hospitalized patients with sepsis or community acquired pneumonia (CAP). We aimed to ascertain the prevalence, clinico-epidemiological and laboratory profile of melioidosis in hospitalized patients with sepsis or CAP, and to evaluate the diagnostic utility of rapid lateral flow immunoassay (LFI) and PCR in comparison with culture. In all patients with sepsis or CAP, blood, sputum/throat swab, and urine sample were subjected to culture along with other samples based on clinical presentation. Read More

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Improvement of pneumococcal pneumonia diagnosis using quantitative real-time PCR targeting lytA in adult patients: A prospective cohort study.

Clin Microbiol Infect 2021 Jun 8. Epub 2021 Jun 8.

Infectious Diseases Unit, Hospital Universitari Mútua de Terrassa, Barcelona; Universitat Internacional de Catalunya. Electronic address:

Objectives: The aim of the study was to assess the performance of real-time polymerase chain reaction (PCR) targeting the lytA gene (rtPCR-lytA) in plasma, urine and nasopharyngeal (NP) samples for the diagnosis of pneumococcal community-acquired pneumonia (P-CAP).

Methods: Prospective observational study including all consecutive adult CAP patients from November 2015 to May 2017. P-CAP was defined if pneumococcus was identified using conventional methods (CM) and/or a positive rtPCR-lytA was detected in blood, urine or NP samples (NP cut-off ≥8000 copies/mL). Read More

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COVID-FACT: A Fully-Automated Capsule Network-Based Framework for Identification of COVID-19 Cases from Chest CT Scans.

Front Artif Intell 2021 25;4:598932. Epub 2021 May 25.

Concordia Institute for Information Systems Engineering (CIISE), Concordia University, Montreal, QC, Canada.

The newly discovered Coronavirus Disease 2019 (COVID-19) has been globally spreading and causing hundreds of thousands of deaths around the world as of its first emergence in late 2019. The rapid outbreak of this disease has overwhelmed health care infrastructures and arises the need to allocate medical equipment and resources more efficiently. The early diagnosis of this disease will lead to the rapid separation of COVID-19 and non-COVID cases, which will be helpful for health care authorities to optimize resource allocation plans and early prevention of the disease. Read More

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Cost-Effectiveness Analysis of 23-Valent Pneumococcal Polysaccharide Vaccine Program for the Elderly Aged 60 Years or Older in Shanghai, China.

Front Public Health 2021 24;9:647725. Epub 2021 May 24.

School of Public Health, Fudan University, Shanghai, China.

The pneumococcal vaccine has been considered as the most effective measure to prevent pneumococcal diseases. In 2013, Shanghai launched a major public health program to vaccinate people aged 60 years or older with 23-Valent Pneumococcal Polysaccharide Vaccine (PPSV-23) free of charge. By the end of June 2020, a total of 1. Read More

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Association between angiotensin-converting enzyme inhibitors or angiotensin receptor blockers and community acquired pneumonia: a nationwide population propensity-score matching study.

Int J Clin Pract 2021 Jun 9:e14476. Epub 2021 Jun 9.

Graduate Institute of Biomedical Sciences and School of Medicine, China Medical University, Taichung, Taiwan.

Background: Few large-scale cohort studies have investigated the association between community acquired pneumonia and the use of angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs). We aimed to study whether using ACEIs or ARBs had protective effects for community acquired pneumonia.

Methods: This database cohort study was conducted retrospectively in Taiwan. Read More

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Hemorrhage and venous thromboembolism in critically ill patients with COVID-19.

SAGE Open Med 2021 31;9:20503121211020167. Epub 2021 May 31.

Department of Vascular Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Objective: The majority of patients with COVID-19 showed mild symptoms. However, approximately 5% of them were critically ill and require intensive care unit admission for advanced life supports. Patients in the intensive care unit were high risk for venous thromboembolism and hemorrhage due to the immobility and anticoagulants used during advanced life supports. Read More

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[A preliminary investigation of the clinical characteristics of community acquired pneumonia with concomitant pulmonary embolism].

Zhonghua Jie He He Hu Xi Za Zhi 2021 Jun;44(6):525-530

Department of Respiratory and Critical Care Medicine, Peking University People's Hospital,Beijing 100044, China.

To understanding the clinical characteristics of the patients of pneumonia concomitant with acute pulmonary embolism, and the early identification of high-risk patients. Retrospective analysis of hospitalized patients with confirmed diagnosis of community acquired pneumonia (CAP) with concomitant pulmonary embolism (PE) within a period of 5 years. Patients hospitalized with CAP alone in the same period were included in the control group in a ratio of 1∶2 according to the principle of gender and age. Read More

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A Self-criticism of Diagnostic and Therapeutic Decision Making in Children Admitted With Acute Lower Respiratory Infection at a Single Pediatric Emergency Department.

Pediatr Emerg Care 2021 Jun 7. Epub 2021 Jun 7.

From the Division of Pediatric Emergency, Ankara City Hospital Division of Pediatrics, Ankara City Hospital, University of Health Sciences Division of Pediatric Radiology, Ankara City Hospital Division of Pediatric Allergy and Immunology, Ankara City Hospital, University of Health Sciences, Ankara, Turkey.

Objectives: Acute bronchiolitis and community-acquired pneumonia are the most common acute lower respiratory infections (LRIs) leading to emergency admission and hospitalization in children. The aim of this study is to investigate clinical, laboratory, and radiology findings; diagnostic and therapeutic decisions; and the relationships between them in patients younger than 2 years of age, hospitalized for LRI.

Methods: Patients hospitalized for acute LRI (aged 28 days to 24 months) between November 1, 2017, and March 31, 2018, at a referral hospital were included. Read More

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