1,654 results match your criteria Pneumonia Atypical Bacterial

Talaromyces marneffei infection in non-HIV-infected patients in mainland China.

Mycoses 2021 Jun 10. Epub 2021 Jun 10.

Department of Dermatology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.

Background: Talaromyces marneffei, formerly known as Penicillium marneffei, is a significant emerging pathogenic fungus in Southeast Asia which can generate life-threatening systemic infections. Human Immunodeficiency Virus (HIV) infection is considered as the most underlying disease among systemic infections. However, infections due to T. Read More

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COVID-19 Infection and Acute Kidney Injury: Cause or Complication?

Blood Purif 2021 Jun 9:1-4. Epub 2021 Jun 9.

San Carlo Borromeo Hospital, ASST Santi Paolo e Carlo, Milan, Italy.

Management of COVID-19 infection is the trend topic in the scientific community and case identification is a key step to contain the pandemic. While pneumonia and acute respiratory distress syndrome represent the typical severe manifestations of the disease, atypical presentations pose significant diagnostic and therapeutic challenges for physicians, especially when diagnostic tests are repeatedly negative. Clinical picture of COVID-19 patients is often complicated by bacterial infections or thrombotic events. Read More

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An AI-based auxiliary empirical antibiotic therapy model for children with bacterial pneumonia using low-dose chest CT images.

Jpn J Radiol 2021 Jun 8. Epub 2021 Jun 8.

Guizhou University, School of Medicine, Guiyang, 550000, Guizhou Province, China.

Purpose: To construct an auxiliary empirical antibiotic therapy (EAT) multi-class classification model for children with bacterial pneumonia using radiomics features based on artificial intelligence and low-dose chest CT images.

Materials And Methods: Data were retrospectively collected from children with pathogen-confirmed bacterial pneumonia including Gram-positive bacterial pneumonia (122/389, 31%), Gram-negative bacterial pneumonia (159/389, 41%) and atypical bacterial pneumonia (108/389, 28%) from January 1 to June 30, 2019. Nine machine-learning models were separately evaluated based on radiomics features extracted from CT images; three optimal submodels were constructed and integrated to form a multi-class classification model. Read More

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Metabolomic profiling of microbial disease etiology in community-acquired pneumonia.

PLoS One 2021 4;16(6):e0252378. Epub 2021 Jun 4.

Division of Systems Biomedicine & Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.

Diagnosis of microbial disease etiology in community-acquired pneumonia (CAP) remains challenging. We undertook a large-scale metabolomics study of serum samples in hospitalized CAP patients to determine if host-response associated metabolites can enable diagnosis of microbial etiology, with a specific focus on discrimination between the major CAP pathogen groups S. pneumoniae, atypical bacteria, and respiratory viruses. Read More

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Reducing the use of empiric antibiotic therapy in COVID-19 on hospital admission.

BMC Infect Dis 2021 Jun 2;21(1):516. Epub 2021 Jun 2.

Department of Medicine, Section of Infectious Diseases and Global Health, The University of Chicago Medicine, Chicago, IL, USA.

Background: Empiric antibiotics for community acquired bacterial pneumonia (CABP) are often prescribed to patients with COVID-19, despite a low reported incidence of co-infections. Stewardship interventions targeted at facilitating appropriate antibiotic prescribing for CABP among COVID-19 patients are needed. We developed a guideline for antibiotic initiation and discontinuation for CABP in COVID-19 patients. Read More

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A patient with psittacosis from a pigeon: A reminder of the importance of detailed interviews and relative bradycardia.

IDCases 2021 18;25:e01164. Epub 2021 May 18.

Department of General Medicine, Juntendo University Faculty of Medicine, Tokyo, Japan.

A 43-year-old man was brought to our hospital with fever. The initial diagnosis was bacterial pneumonia, and ampicillin/sulbactam was administered. However, defervescence was not achieved, and relative bradycardia was observed. Read More

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Profile of co-infections & secondary infections in COVID-19 patients at a dedicated COVID-19 facility of a tertiary care Indian hospital: Implication on antimicrobial resistance.

Indian J Med Microbiol 2021 04 2;39(2):147-153. Epub 2020 Nov 2.

Department of Laboratory Medicine (Microbiology), JPN Apex Trauma Center, All India Institute of Medical Sciences, New Delhi, India. Electronic address:

Background: The COVID-19 pandemic has raised concerns over secondary infections because it has limited treatment options and empiric antimicrobial treatment poses serious risks of aggravating antimicrobial resistance (AMR). Studies have shown that COVID-19 patients are predisposed to develop secondary infections. This study was conducted to ascertain the prevalence and profiles of co- & secondary infections in patients at the COVID-19 facility in North India. Read More

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Use of antibiotics in COVID-19 ICU patients.

J Infect Dev Ctries 2021 04 30;15(4):501-505. Epub 2021 Apr 30.

University for Busines and Technology, Pristina, Kosovo.

Introduction: The role of antibiotics in the treatment in COVID-19 cases has not yet been adequately defined, and no criteria have been established for antibiotic treatment, type and duration.

Methodology: This paper reports the results of an observational study on the extent of antibiotic use in 52 randomly selected patients in the intensive care unit (ICU) at the University Hospital in Pristina, Kosovo with severe forms of COVID-19.

Results: Antibiotics were prescribed in all the cases (52; 100%). Read More

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Bacterial coinfections in coronavirus disease 2019.

Trends Microbiol 2021 Apr 8. Epub 2021 Apr 8.

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA; Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY, USA. Electronic address:

Bacterial coinfections increase the severity of respiratory viral infections and were frequent causes of mortality in influenza pandemics but have not been well characterized in patients with coronavirus disease 2019 (COVID-19). The aim of this review was to identify the frequency and microbial etiologies of bacterial coinfections that are present upon admission to the hospital and that occur during hospitalization for COVID-19. We found that bacterial coinfections were present in <4% of patients upon admission and the yield of routine diagnostic tests for pneumonia was low. Read More

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Etiology of Clinical Community-Acquired Pneumonia in Swedish Children Aged 1-59 Months with High Pneumococcal Vaccine Coverage-The TREND Study.

Vaccines (Basel) 2021 Apr 14;9(4). Epub 2021 Apr 14.

Pediatric Emergency Department, Sachs' Children and Youth Hospital, S-118 83 Stockholm, Sweden.

(1) Immunization with pneumococcal conjugate vaccines has decreased the burden of community-acquired pneumonia (CAP) in children and likely led to a shift in CAP etiology. (2) The Trial of Respiratory infections in children for ENhanced Diagnostics (TREND) enrolled children 1-59 months with clinical CAP according to the World Health Organization (WHO) criteria at Sachs' Children and Youth Hospital, Stockholm, Sweden. Children with rhonchi and indrawing underwent "bronchodilator challenge". Read More

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Hepcidin and Ferritin Predict Microbial Etiology in Community-Acquired Pneumonia.

Open Forum Infect Dis 2021 Apr 18;8(4):ofab082. Epub 2021 Feb 18.

Department of Internal Medicine, Drammen Hospital, Vestre Viken Hospital Trust, Drammen, Norway.

Background: Iron is crucial for survival and growth of microbes. Consequently, limiting iron availability is a human antimicrobial defense mechanism. We explored iron and iron-related proteins as potential biomarkers in community-acquired pneumonia and hypothesized that infection-induced changes in these potential biomarkers differ between groups of pathogens and could predict microbial etiology. Read More

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Seasonality in testing and positive respiratory bacterial infections in the Australian Capital Territory, 1997-2007.

Commun Dis Intell (2018) 2021 Mar 31;45. Epub 2021 Mar 31.

Research School of Population Health, Australian National University.

Background: Chlamydia pneumoniae (Cp) and Mycoplasma pneumoniae (Myco) bacteria are atypical pathogens that can cause pneumonia and exacerbate underlying conditions such as asthma and chronic obstructive pulmonary disease. In the Australian Capital Territory, there is limited information on how seasonal patterns for positive infections and testing may vary, a gap that has implications for control strategies.

Methods: We examined seasonal patterns of immunoassay results of patients from Canberra Hospital, Australia, who were tested for Cp and/or Myco. Read More

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Mucosal Respiratory Syndrome: A Systematic Literature Review.

Dermatology 2021 Mar 26:1-7. Epub 2021 Mar 26.

Pediatric Institute of Southern Switzerland, Ospedale San Giovanni, Bellinzona, Switzerland.

Background: Mycoplasma pneumoniae atypical pneumonia is frequently associated with erythema multiforme. Occasionally, a mycoplasma infection does not trigger any cutaneous but exclusively mucosal lesions. The term mucosal respiratory syndrome is employed to denote the latter condition. Read More

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Accuracy of Chest CT for Differentiating COVID-19 from COVID-19 Mimics.

Rofo 2021 Mar 26. Epub 2021 Mar 26.

Department of Diagnostic and Interventional Radiology, Universitätsklinikum Aachen, Germany.

Purpose:  To determine the performance of radiologists with different levels of expertise regarding the differentiation of COVID-19 from other atypical pneumonias. Chest CT to identify patients suffering from COVID-19 has been reported to be limited by its low specificity for distinguishing COVID-19 from other atypical pneumonias ("COVID-19 mimics"). Meanwhile, the understanding of the morphologic patterns of COVID-19 has improved and they appear to be fairly specific. Read More

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Retrospective review analysis of COVID-19 patients co-infected with .

Lung India 2021 Mar;38(Supplement):S22-S26

Department of Respiratory Medicine, Doncaster Royal Infirmary, UK.

Introduction: Coronavirus disease 2019 (COVID-19) is an extremely infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The outbreak of this virus has resulted in significant morbidity and mortality throughout the world. We have seen an unprecedented spread of this virus, leading to extreme pressure on health-care services. Read More

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SP-D Serum Levels Reveal Distinct Epithelial Damage in Direct Human ARDS.

J Clin Med 2021 Feb 12;10(4). Epub 2021 Feb 12.

Department of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Venusberg-Campus 1, 53127 Bonn, Germany.

Acute respiratory distress syndrome (ARDS) is a heterogeneous syndrome with multiple underlying diseases. Particularly epithelial damage results from direct (e.g. Read More

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February 2021

[Dihydropteroate Synthase (DHPS) Gene Mutations and Mitochondrial Large Subunit (mtLSU) rRNA Genotype Variations in Pneumocystis jirovecii Strains].

Mikrobiyol Bul 2021 Jan;55(1):41-52

Mersin University Faculty of Medicine, Department of Medical Microbiology, Mersin, Turkey.

Pneumocystis jirovecii is an atypical fungus that causes Pneumocystis pneumonia (PCP) in HIV/AIDS and immunocompromised patients. Antibiotics containing sulfa and sulfone groups are widely used in PCP prophylaxis and treatment. Especially, long-term use of trimethoprim sulfamethoxazole (TMP-SMX) is known to cause certain point mutations associated with drug resistance in the P. Read More

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January 2021

Half of all hospitalised children treated with antibiotics for pneumonia did not fulfil radiological, microbiological or laboratory criteria.

Acta Paediatr 2021 06 19;110(6):1924-1931. Epub 2021 Feb 19.

Department of Clinical Science, Faculty of Medicine, University of Bergen, Bergen, Norway.

Aim: Evaluating the management of paediatric pneumonia is important. We aimed to estimate the proportion of children receiving antibiotics for suspected community-acquired pneumonia (CAP) that were likely to have a bacterial infection. Furthermore, we described antibiotic use in relation to guidelines. Read More

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Aortoenteric fistula after endovascular mycotic aortic aneurysm exclusion: lessons learned during the COVID-19 era.

BMJ Case Rep 2021 Feb 5;14(2). Epub 2021 Feb 5.

Vascular Surgery, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, Lancashire, UK.

We report a case of aortoenteric fistula 2 years following endovascular aortic aneurysm repair (EVAR) for mycotic aneurysm presenting as upper gastrointestinal bleeding. Initial CT angiogram did not reveal the bleeding or connection to bowel, but endoscopy was suspicious of endograft in the duodenum. Management required a multidisciplinary approach. Read More

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February 2021

Repurposing of Tetracyclines for COVID-19 Neurological and Neuropsychiatric Manifestations: A Valid Option to Control SARS-CoV-2-Associated Neuroinflammation?

J Neuroimmune Pharmacol 2021 06 3;16(2):213-218. Epub 2021 Feb 3.

Neuropharmacology Laboratory, Drug Research and Development Center, Department of Physiology and Pharmacology, Faculty of Medicine, Universidade Federal Do Ceará, Fortaleza, CE, Brazil.

The recent outbreak of coronavirus disease 2019 (COVID-19) has gained considerable attention worldwide due to its increased potential to spread and infect the general population. COVID-19 primarily targets the human respiratory epithelium but also has neuro-invasive potential. Indeed, neuropsychiatric manifestations, such as fatigue, febrile seizures, psychiatric symptoms, and delirium, are consistently observed in COVID-19. Read More

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Treatment of Community-Acquired Pneumonia: A Focus on Lefamulin.

Infect Dis Ther 2021 Mar 2;10(1):149-163. Epub 2021 Feb 2.

Department of Pharmacy, Memorial Regional Hospital, Hollywood, FL, USA.

Objective: The goal of this article is to review the clinical pharmacology, pharmacokinetics, efficacy, and safety of lemafulin.

Data Sources: We performed a systematic literature review using the search terms of lefamulin and BC-3781 in the PubMed and EMBASE databases. We also cross-referenced the pertinent articles and searched ClinicalTrials. Read More

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Diagnostic challenge: an atypical presentation of infective endocarditis.

BMJ Case Rep 2021 Jan 25;14(1). Epub 2021 Jan 25.

Lincolnshire Heart Centre, United Lincolnshire Hospitals NHS Trust, Lincoln, Lincolnshire, UK.

It is recognised that infective endocarditis is frequently a challenging diagnosis to make, as it may present with a range of non-specific symptoms. A middle-aged man was admitted with an 8-day history of profuse non-bloody diarrhoea and vomiting. He had no medical history and no identifiable risk factors for infective endocarditis, and so this in combination with the patient's atypical symptoms presented a diagnostic challenge. Read More

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January 2021

High burden of infections in Indian patients with Idiopathic Inflammatory Myopathy: Validation of Observations from the MyoCite dataset.

Rheumatology (Oxford) 2021 Jan 25. Epub 2021 Jan 25.

Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Objective: To determine the prevalence, profile and predictors of infections in an Indian cohort of IIM.

Methods: We reviewed the records of a retrospective cohort of IIM enrolled from consecutive patients following up in the clinic as the observation cohort (OC). A newly diagnosed inception cohort of IIM were followed prospectively as the validation cohort (VC) to confirm observations and compare with the OC. Read More

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January 2021

Successful treatment of COVID-19 infection in a patient with tracheostomy.

Tuberk Toraks 2020 Dec;68(4):444-448

Department of Chest Diseases, Ankara University Faculty of Medicine, Ankara, Turkey.

Coronavirus disease 2019 (COVID-19) has been demonstrated to be the cause of emerging atypical pneumonia. In patients with tracheostomy, coronavirus hypothetically coexists with well-known bacterial agents. A 61-year-old male patient with tracheostomy was admitted to the hospital with dyspnea, fever and increased tracheal secretions. Read More

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December 2020

Recommendations on off-label use of intravenous azithromycin in children.

Int J Clin Pract 2021 Jan 9:e14010. Epub 2021 Jan 9.

Department of Pharmacy, Peking University Third Hospital, Beijing, China.

Objective: Intravenous azithromycin (AZM) has been widely used in children worldwide, but there still remains much concern regarding its off-label use, which urgently needs to be regulated. Therefore, we developed a rapid advice guideline in China to give recommendations of rational use of intravenous AZM in children.

Methods: This guideline focuses on antimicrobial therapy with intravenous AZM in children. Read More

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January 2021

pneumonia: a rare cause of infection in the multimorbid or immunocompromised.

BMJ Case Rep 2020 Dec 31;13(12). Epub 2020 Dec 31.

Respiratory Medicine, Tunbridge Wells Hospital, Tunbridge Wells, UK.

is a rare, poorly understood commensal bacterium which has, on occasion, been shown to infect humans. We present two cases. The first patient presented with a 1-week history of dyspnoea, pleurisy and a productive cough, and the second with a prodrome of fatigue and night sweats. Read More

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December 2020

Activation of the Legionella pneumophila LegK7 Effector Kinase by the Host MOB1 Protein.

J Mol Biol 2021 02 10;433(3):166746. Epub 2020 Dec 10.

Division of Biomedical Convergence, College of Biomedical Science, Kangwon National University, Chuncheon 24341, Republic of Korea; Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon 24341, Republic of Korea. Electronic address:

Legionella pneumophila infects alveolar macrophages and can cause life-threatening pneumonia in humans. Upon internalization into the host cell, L. pneumophila injects numerous effector proteins into the host cytoplasm as a part of its pathogenesis. Read More

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February 2021

Physicians' prediction for the assessment of atypical pathogens in respiratory tract infections.

J Gen Fam Med 2020 Nov 25;21(6):226-234. Epub 2020 Jun 25.

Faculty of Medicine University of Tsukuba Tsukuba Japan.

Background: Patients with acute respiratory tract infections are frequently prescribed antimicrobials despite high rates of virus detection. Physicians may overprescribe antimicrobials owing to the concern of bacterial infections, including those because of atypical pathogens. We investigated the accuracy of clinical predictions concerning atypical pathogen infections. Read More

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November 2020

Eosinophilic Leukaemia and Systemic Mycobacterium marinum Infection in an African Pygmy Hedgehog (Atelerix albiventris).

J Comp Pathol 2020 Nov 29;181:33-37. Epub 2020 Oct 29.

Kyoto Institute of Nutrition and Pathology Inc, Kyoto, Faculty of Pharmaceutical Science, Setsunan University, Japan.

A two-year-old male African pygmy hedgehog (Atelerix albiventris) presented with lethargy and anorexia. Ultrasonographic and radiographic examinations revealed splenomegaly and pneumonia, respectively. Prominent leucocytosis, consisting mainly of large atypical eosinophils, was observed in a peripheral blood smear. Read More

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November 2020

Multicentric evaluation of BioFire FilmArray Pneumonia Panel for rapid bacteriological documentation of pneumonia.

Clin Microbiol Infect 2020 Dec 1. Epub 2020 Dec 1.

Service de Bactériologie-Hygiène hospitalière, CHU de Rennes, CNR de la Résistance aux Antibiotiques (laboratoire associé 'Entérocoques), Rennes, France; Unité Inserm U1230, Université de Rennes 1, Rennes, France. Electronic address:

Objectives: To evaluate performances of the rapid multiplex PCR assay BioFire FilmArray Pneumonia Panel (FA-PP) for detection of bacterial pathogens and antibiotic resistance genes in sputum, endotracheal aspirate (ETA) and bronchoalveolar lavage (BAL) specimens.

Methods: This prospective observational study was conducted in 11 French university hospitals (July to December 2018) and assessed performance of FA-PP by comparison with routine conventional methods.

Results: A total of 515 respiratory specimens were studied, including 58 sputa, 217 ETA and 240 BAL. Read More

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December 2020