1,584 results match your criteria Pneumonia Atypical Bacterial


[Etiology of severe community - acquired pneumonia in adults: results of the first Russian multicenter study].

Ter Arkh 2020 Jan 15;92(1):36-42. Epub 2020 Jan 15.

M.K. Ammosov Federal North-Eastern University.

Aim: to study the etiology of severe community - acquired pneumonia (SCAP) in adults in Russian Federation. SCAP is distinguished by high mortality and socio - economic burden. Both etiology and antimicrobial resistance are essential for appropriate antibiotic choice. Read More

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http://dx.doi.org/10.26442/00403660.2020.01.000491DOI Listing
January 2020

Evaluating the use of a 22-pathogen TaqMan array card for rapid diagnosis of respiratory pathogens in intensive care.

J Med Microbiol 2020 Jun 18. Epub 2020 Jun 18.

NHS GGC, Glasgow Royal Infirmary, Department of Clinical Microbiology, New Lister Building, Alexandra Parade, Glasgow, UK.

Pneumonia is highly prevalent in intensive care units (ICUs), with high associated mortality. Empirical treatment prioritizes breadth of coverage while awaiting laboratory diagnosis, often at the expense of antimicrobial stewardship. Microarrays use multiple parallel polymerase chain reactions to enable a rapid syndromic approach to laboratory diagnosis. Read More

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http://dx.doi.org/10.1099/jmm.0.001218DOI Listing

Efficacy of delafloxacin versus moxifloxacin against atypical bacterial respiratory pathogens in adults with community-acquired bacterial pneumonia (CABP): data from the delafloxacin phase 3 CABP trial.

Int J Infect Dis 2020 Jun 10. Epub 2020 Jun 10.

Melinta Therapeutics Morristown, New Jersey. Electronic address:

Objectives: To report atypical pathogen clinical trial data comparing delafloxacin to moxifloxacin in treatment of adults with community-acquired bacterial pneumonia (CABP).

Methods: Multiple diagnostic methods were employed to diagnose atypical infections including culture, serology, and urinary antigen.

Results: The microbiological intent-to-treat (MITT) population included 520 patients; 30% had an atypical bacterial pathogen identified (156/520). Read More

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http://dx.doi.org/10.1016/j.ijid.2020.06.018DOI Listing

Comparative pathogenesis of bovine and porcine respiratory coronaviruses in the animal host species and SARS-CoV-2 in humans.

J Clin Microbiol 2020 Jun 10. Epub 2020 Jun 10.

Food Animal Health Research Program, Ohio Agricultural Research and Development Center, College of Food, Agricultural, and Environmental Sciences, Department of Veterinary Preventive Medicine, The Ohio State University, Wooster, Ohio, USA

Discovery of bats with severe acute respiratory syndrome (SARS)-related coronaviruses (CoVs) raised the spector of potential future outbreaks of zoonotic SARS-CoV-like disease in humans, which largely went unheeded. Nevertheless, the novel SARS-CoV-2 of bat ancestoral origin emerged to infect humans in Wuhan, China in late 2019 and then became a global pandemic. Less than 5 months after its emergence, millions of people worldwide have been infected asymptomatically or symptomatically and at least 360,000 have died. Read More

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http://dx.doi.org/10.1128/JCM.01355-20DOI Listing

Lefamulin: The First Systemic Pleuromutilin Antibiotic.

Ann Pharmacother 2020 Jun 4:1060028020932521. Epub 2020 Jun 4.

Regis University School of Pharmacy, Denver, CO, USA.

To review the pharmacology, microbiology, efficacy, and safety of lefamulin. A literature search was performed using PubMed and Google Scholar (2010 to end-April 2020) with the search terms and . Other resources included abstracts presented at recent conferences, prescribing information, and the manufacturer's and Food and Drug Administration websites. Read More

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http://dx.doi.org/10.1177/1060028020932521DOI Listing

Acute eosinophilic pneumonia with sepsis-like symptoms of arthralgia, joint stiffness and lymph node enlargement: A case report.

Respir Med Case Rep 2020 29;30:101072. Epub 2020 Apr 29.

Department of Respiratory and Critical Care Medicine, Guizhou Provincial People's Hospital, Guiyang City, Guizhou Province, China.

Background: Acute eosinophilic pneumonia (AEP) is an acute febrile disease with good prognosis. It is often manifested as cough, dyspnea and fever, and sometimes may also as myalgia. However, there are no reports of AEP with sepsis-like symptoms of arthralgia, joint stiffness, lymph node enlargement, transient rashes and abnormal liver function in the literature. Read More

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http://dx.doi.org/10.1016/j.rmcr.2020.101072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251375PMC

Adherence to Treatment Guideline Improves Patient Outcomes in a Prospective Cohort of Adults Hospitalized for Community-Acquired Pneumonia.

Open Forum Infect Dis 2020 May 24;7(5):ofaa146. Epub 2020 Apr 24.

Department of Microbiology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.

Background: Understanding local epidemiology and etiologies of community-acquired pneumonia in hospitalized patients is crucial for determining the appropriateness of treatment guidelines. We aim to determine the etiologies, severity, and outcomes in adults hospitalized for community-acquired pneumonia and to study the impact of empirical antibiotic therapy on patient outcomes.

Methods: We performed a prospective observational cohort study involving adults hospitalized for community-acquired pneumonia in Hong Kong. Read More

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http://dx.doi.org/10.1093/ofid/ofaa146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243378PMC

Delayed diagnosis of fatal pneumonic canine plague: clinical and pathologic features in two naturally infected Colorado dogs.

BMC Vet Res 2020 May 25;16(1):160. Epub 2020 May 25.

Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.

Background: Plague caused by Yersinia pestis is a highly infectious and potentially fatal zoonotic disease that can be spread by wild and domestic animals. In endemic areas of the northern hemisphere plague typically cycles from March to October, when flea vectors are active. Clinical forms of disease include bubonic, septicemic, and pneumonic plague. Read More

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http://dx.doi.org/10.1186/s12917-020-02361-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249295PMC

Presenting characteristics, comorbidities, and outcomes of patients coinfected with COVID-19 and Mycoplasma pneumoniae in the USA.

J Med Virol 2020 May 25. Epub 2020 May 25.

Division of Nephrology, Department of Internal Medicine, Adventist Medical Center, Hanford, California.

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) is spreading at a rapid pace, and the World Health Organization declared it as pandemic on 11 March 2020. Mycoplasma pneumoniae is an "atypical" bacterial pathogen commonly known to cause respiratory illness in humans. The coinfection from SARS-CoV-2 and mycoplasma pneumonia is rarely reported in the literature to the best of our knowledge. Read More

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http://dx.doi.org/10.1002/jmv.26026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280653PMC
May 2020
2.347 Impact Factor

biofilms grown : traits associated with persistence and cytotoxicity.

Microbiology 2020 May 18. Epub 2020 May 18.

Department of Microbiology, Miami University, 212 Pearson Hall, Oxford, OH 45056, USA.

The atypical bacterial pathogen is a leading etiological agent of community-acquired pneumonia in humans; infections are often recalcitrant, recurrent and resistant to antibiotic treatment. These characteristics suggest a mechanism that facilitates long-term colonization in hosts. In an setting, forms biofilms that are unusual in that motility plays no more than a very limited role in their formation and development. Read More

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http://dx.doi.org/10.1099/mic.0.000928DOI Listing

Assessment and treatment of older individuals with COVID 19 multi-system disease: Clinical and ethical implications.

Acta Biomed 2020 May 11;91(2):150-168. Epub 2020 May 11.

Geriatric Clinic Unit, Parma University Hospital of Parma, Italy Postgraduate School of Geriatric Medicine, Department of Medicine and Surgery, University of Parma, Italy.

Covid-19 infection is a multisystem disease more frequent in older individuals, especially in those with multiple chronic diseases. This multimorbid and frail population requires attention and a personalized comprehensive assessment in order to avoid the occurrence of adverse outcomes. As other diseases, the COVID-19 presentation in older patients is often atypical with less severe and unspecific symptoms. Read More

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http://dx.doi.org/10.23750/abm.v91i2.9629DOI Listing

[COVID-19 associated pneumonia despite repeatedly negative PCR-analysis from oropharyngeal swabs].

Dtsch Med Wochenschr 2020 06 13;145(12):844-849. Epub 2020 May 13.

Klinik für Innere Medizin II, Gastroenterologie, Hepatologie, Endokrinologie und Infektiologie, Universitätsklinikum Freiburg.

Patient History And Clinical Findings: A 46-year old construction worker presented at the emergency department with two orthostatic syncopes. The patient complained of prolonged fever and coughs for 7 days which had not improved after oral treatment with sultamicillin for 5 days, prescribed by the patient's general practitioner. Physical examination showed high blood pressure due to previously known hypertension. Read More

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http://dx.doi.org/10.1055/a-1170-6061DOI Listing

Multicenter Evaluation of the BioFire FilmArray Pneumonia/Pneumonia Plus Panel for Detection and Quantification of Agents of Lower Respiratory Tract Infection.

J Clin Microbiol 2020 Jun 24;58(7). Epub 2020 Jun 24.

BioFire Diagnostics LLC, Salt Lake City, Utah, USA.

The ability to provide timely identification of the causative agents of lower respiratory tract infections can promote better patient outcomes and support antimicrobial stewardship efforts. Current diagnostic testing options include culture, molecular testing, and antigen detection. These methods may require collection of various specimens, involve extensive sample treatment, and can suffer from low sensitivity and long turnaround times. Read More

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http://dx.doi.org/10.1128/JCM.00128-20DOI Listing

Case Report: The First Case of COVID-19 in Bhutan.

Am J Trop Med Hyg 2020 06;102(6):1205-1207

Jigme Dorji Wangchuck National Referral Hospital (JDWNRH), Khesar Gyalpo University of Medical Sciences of Bhutan (KGUMSB), Thimphu, Bhutan.

The initial cases of novel coronavirus disease-19 (COVID-19) in a country are of utmost importance given their impact on healthcare providers, the country's preparedness response, and the initial molding of the public perception toward this pandemic. In Bhutan, the index case was a 76-year-old immunocompromised man who had traveled from the United States and entered Bhutan as a tourist. He presented initially with vague gastrointerestinal symptoms and later a cough. Read More

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http://dx.doi.org/10.4269/ajtmh.20-0259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253094PMC

Lefamulin: A Novel Semisynthetic Pleuromutilin Antibiotic for Community-Acquired Bacterial Pneumonia.

Clin Infect Dis 2020 Mar 28. Epub 2020 Mar 28.

Department of Medicine, Northeast Ohio Medical University, Rootstown, OH.

Community-acquired bacterial pneumonia (CABP) remains a significant cause of morbidity and mortality worldwide. Antimicrobial resistance, including in pathogens that cause CABP, continues to spread at an alarming rate. Because of these factors, the development of new antibiotic classes is urgently needed. Read More

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http://dx.doi.org/10.1093/cid/ciaa336DOI Listing

[MORAXELLA OSLOENSIS BACTEREMIA WITH PNEUMONIA: FIRST REPORTED CASE IN ISRAEL].

Harefuah 2020 Mar;159(3):163-165

Galilee Medical Center, Department of Internal Medicine "D", Nahariya.

Introduction: Community acquired pneumonia (CAP), an acute infection of the pulmonary parenchyma acquired in the community, is generally treated in an outpatient setting and involves different etiological agents. In the adult community, the most common pathogen in the disease is Streptococcus pneumonia, though other multiple etiological agents (atypical) have been involved, including Mycoplasma pneumoniae, Chlamydophila pneumoniae, and Legionella pneumophila. The genus Moraxella consists of aerobic, oxidase-positive gram-negative coccobacilli. Read More

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Clinical Features of Human Metapneumovirus-Associated Community-Acquired Pneumonia Hospitalizations.

Clin Infect Dis 2020 Feb 3. Epub 2020 Feb 3.

Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN.

Background: Human metapneumovirus (HMPV) is a leading cause of respiratory tract infections. Few studies have compared the clinical characteristics and severity of HMPV-associated pneumonia with other pathogens.

Methods: Active population-based surveillance was previously conducted for radiographically-confirmed community-acquired pneumonia hospitalizations among children and adults in eight United States hospitals. Read More

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http://dx.doi.org/10.1093/cid/ciaa088DOI Listing
February 2020

Clinical Pharmacokinetics and Pharmacodynamics of Imipenem-Cilastatin/Relebactam Combination Therapy.

Clin Pharmacokinet 2020 May;59(5):567-573

Weill Cornell Medical College, New York, USA.

On 16 July, 2019, the US Food and Drug Administration approved imipenem-cilastatin/relebactam (Recarbrio™) for the treatment of adults with complicated urinary tract infections and complicated intra-abdominal infections. This decision was based on substantial clinical and pre-clinical data, including rigorous pharmacokinetic and pharmacodynamic work, and is an important step forward in the management of these debilitating conditions. This article provides an overview of the body of research associated with imipenem-cilastatin/relebactam, beginning with an examination of the fundamental underpinnings of the pharmacokinetic/pharmacodynamic index. Read More

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http://dx.doi.org/10.1007/s40262-020-00865-3DOI Listing

A Phase 3 Study to Compare Delafloxacin With Moxifloxacin for the Treatment of Adults With Community-Acquired Bacterial Pneumonia (DEFINE-CABP).

Open Forum Infect Dis 2020 Jan 5;7(1):ofz514. Epub 2019 Dec 5.

Melinta Therapeutics, Lincolnshire, Illinois, USA.

Background: The clinical and economic burden of community-acquired bacterial pneumonia (CABP) is significant and is anticipated to increase as the population ages and pathogens become more resistant. Delafloxacin is a fluoroquinolone antibiotic approved in the United States for the treatment of adults with acute bacterial skin and skin structure infections. Delafloxacin's shape and charge profile uniquely impact its spectrum of activity and side effect profile. Read More

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http://dx.doi.org/10.1093/ofid/ofz514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6975251PMC
January 2020

Omadacycline: A Novel Oral and Intravenous Aminomethylcycline Antibiotic Agent.

Drugs 2020 Feb;80(3):285-313

Department of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.

Omadacycline is a novel aminomethylcycline antibiotic developed as a once-daily, intravenous and oral treatment for acute bacterial skin and skin structure infection (ABSSSI) and community-acquired bacterial pneumonia (CABP). Omadacycline, a derivative of minocycline, has a chemical structure similar to tigecycline with an alkylaminomethyl group replacing the glycylamido group at the C-9 position of the D-ring of the tetracycline core. Similar to other tetracyclines, omadacycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. Read More

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http://dx.doi.org/10.1007/s40265-020-01257-4DOI Listing
February 2020

An overview of lefamulin for the treatment of community acquired bacterial pneumonia.

Expert Opin Pharmacother 2020 Apr 20;21(6):629-636. Epub 2020 Jan 20.

Infectious Diseases Department, University Hospital Vall d'Hebron, Autonomous University of Barcelona , Barcelona, Spain.

Introduction: Lefamulin is a novel antibiotic that belongs to the pleuromutilin class with excellent activity against all microorganisms, including atypical pathogens, that cause community-acquired pneumonia (CAP).

Areas Covered: This article reviews the spectrum of activity, the main pharmacokinetic and pharmacodynamic characteristics of lefamulin as well as its clinical efficacy and safety in the treatment of CAP in adult patients.

Expert Opinion: The clinical efficacy of lefamulin in patients with non severe CAP has been demonstrated in 2 randomized clinical trials. Read More

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http://dx.doi.org/10.1080/14656566.2020.1714592DOI Listing

Infective myositis, an uncommon presentation of melioidosis: a case report and review of the literature.

J Med Case Rep 2019 Dec 31;13(1):388. Epub 2019 Dec 31.

Teaching Hospital Peradeniya, Peradeniya, Sri Lanka.

Background: Melioidosis is considered endemic in certain areas of the world. Musculoskeletal and soft tissue involvement are relatively uncommon presentations in melioidosis. We present a case of infective myositis in a patient with melioidosis in Sri Lanka, which is not considered an endemic country. Read More

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http://dx.doi.org/10.1186/s13256-019-2321-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937802PMC
December 2019

Efficacy of Delafloxacin versus Moxifloxacin against Bacterial Respiratory Pathogens in Adults with Community-Acquired Bacterial Pneumonia (CABP): Microbiology Results from the Delafloxacin Phase 3 CABP Trial.

Antimicrob Agents Chemother 2020 02 21;64(3). Epub 2020 Feb 21.

Melinta Therapeutics, Morristown, New Jersey, USA.

Delafloxacin is a novel fluoroquinolone with activity against Gram-positive, Gram-negative, and atypical pathogens, including fluoroquinolone-nonsusceptible methicillin-resistant (MRSA). The microbiological results of a phase 3 clinical trial in adults with community-acquired pneumonia (CAP) comparing delafloxacin (300 mg intravenously [i.v. Read More

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http://dx.doi.org/10.1128/AAC.01949-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038307PMC
February 2020

Primary pyogenic ventriculitis caused by Streptococcal pneumoniae in adults.

J Family Med Prim Care 2019 Nov 15;8(11):3745-3747. Epub 2019 Nov 15.

Department of Medicine- Endocrinology, Pondicherry Institute of Medical Sciences, Puducherry, India.

Primary pyogenic ventriculitis is more commonly manifested in children. Its presentation in adults due to is rarely reported. It is mainly due to adequate vaccination cover and initiation of appropriate antibiotics. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_688_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881931PMC
November 2019

The Usefulness of Lung Ultrasound for the Aetiological Diagnosis of Community-Acquired Pneumonia in Children.

Sci Rep 2019 11 29;9(1):17957. Epub 2019 Nov 29.

University Medical Centre Maribor, Division of Pediatrics, Ljubljanska ulica 5, 2000, Maribor, Slovenia.

The aetiology of community-acquired pneumonia (CAP) is not easy to establish. As lung ultrasound (LUS) has already proved to be an excellent diagnostic tool for CAP, we analysed its usefulness for discriminating between the aetiologically different types of CAP in children. We included 147 children hospitalized because of CAP. Read More

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http://dx.doi.org/10.1038/s41598-019-54499-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884636PMC
November 2019

Pleural effusion as an atypical presentation of Kawasaki disease: a case report and review of the literature.

J Med Case Rep 2019 Nov 25;13(1):344. Epub 2019 Nov 25.

Department of Pediatric Rheumatology, Hacettepe University Faculty of Medicine, 06100, Ankara, Turkey.

Background: Kawasaki disease is an acute, febrile vasculitis of childhood that affects medium-sized arteries, predominantly the coronary arteries. It is a multisystem disease; therefore, it may present with non-cardiac findings of disease.

Case Presentation: Here, we report the case of 7-year-old Turkish girl who presented with symptoms of fever, chest pain, and vomiting, who was diagnosed as having Kawasaki disease. Read More

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http://dx.doi.org/10.1186/s13256-019-2284-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876070PMC
November 2019

Management of community-acquired bacterial pneumonia in adults: Limitations of current antibiotics and future therapies.

Lung India 2019 Nov-Dec;36(6):525-533

Department of Medical Affairs, Wockhardt Ltd., BKC, Mumbai, Maharashtra, India.

Community-acquired bacterial pneumonia (CABP) is one of the leading causes of morbidity and mortality in India and worldwide. Evidence indicates that Gram-positive, Gram-negative, and atypical bacteria are encountered with near-equal frequency. Despite guideline recommendations and antibiotic options for the management of CABP, burden of morbidity and mortality is high, which is attributable to a variety of factors. Read More

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http://dx.doi.org/10.4103/lungindia.lungindia_38_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852216PMC
November 2019

Atypical presentation of Lemierre's syndrome: case report and literature review.

BMC Infect Dis 2019 Oct 21;19(1):868. Epub 2019 Oct 21.

Service of Infectious Diseases, Department of Medicine, Geneva University Hospitals and the University of Geneva, 4 Rue Gabrielle-Perret-Gentil, 1211, Geneva 14, Switzerland.

Background: The classic Lemierre's syndrome refers to a septic thrombosis of the internal jugular vein, usually caused by a Fusobacterium necrophorum infection starting in the oral cavity, and typically complicated by pulmonary emboli. However, unusual forms of the disorder have been rarely reported.

Case Presentation: We describe an unusual case of a previously healthy 58-year-old male with Lemierre's syndrome, manifesting with lumbar pain and fever. Read More

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http://dx.doi.org/10.1186/s12879-019-4538-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805316PMC
October 2019
2 Reads

The Clinical Picture and Severity of Invasive Meningococcal Disease Serogroup W Compared With Other Serogroups in the Netherlands, 2015-2018.

Clin Infect Dis 2020 May;70(10):2036-2044

Centre for Infectious Disease Control Netherlands (Cib), National Institute for Public Health and the Environment (RIVM), Bilthoven.

Background: An increase in invasive meningococcal disease (IMD) serogroup W (IMD-W) cases caused by sequence type-11 clonal complex (cc11) was observed from October 2015 in the Netherlands. We compared the clinical picture and disease outcome of IMD-W cases with other serogroups, adjusting for host characteristics.

Methods: We included IMD cases reported from January 2015 to June 2018 in the Netherlands and assessed clinical manifestation and symptoms at disease onset and calculated case fatality rates (CFRs). Read More

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http://dx.doi.org/10.1093/cid/ciz578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201410PMC
May 2020
4 Reads

Coxiella burnetii Intratracheal Aerosol Infection Model in Mice, Guinea Pigs, and Nonhuman Primates.

Infect Immun 2019 12 18;87(12). Epub 2019 Nov 18.

Department of Microbial Pathogenesis and Immunology, College of Medicine, Texas A&M University, Bryan, Texas, USA

, the etiological agent of Q fever, is a Gram-negative bacterium transmitted to humans by inhalation of contaminated aerosols. Acute Q fever is often self-limiting, presenting as a febrile illness that can result in atypical pneumonia. In some cases, Q fever becomes chronic, leading to endocarditis that can be life threatening. Read More

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http://dx.doi.org/10.1128/IAI.00178-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6867829PMC
December 2019
1 Read

An atypical sternoclavicular septic arthritis that was treated conservatively.

G Chir 2019 May-Jun;40(3):243-247

Sternoclavicular joint infection is rare. While it is usually treated surgically, we wish to report a case of non-operative treatment of such infection caused by an atypical organism. A 51-year-old woman, known case of diabetes mellitus, hypertension, dyslipidaemia and hyperthyroidism presented with pain over the left upper chest for two weeks associated with redness and fever for one week. Read More

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February 2020
2 Reads

The prevalence of respiratory pathogens in adults with community-acquired pneumonia in an outpatient cohort.

Infect Drug Resist 2019 30;12:2335-2341. Epub 2019 Jul 30.

Department of Infectious Disease, Peking University Third Hospital, Beijing, People's Republic of China.

Purpose: Community-acquired pneumonia is a common illness worldwide. In adults, community-acquired bacterial pneumonia has been well studied, but viral pneumonia is less well understood. We designed this study to identify respiratory pathogens, including common pneumonia-causing bacteria, viruses and atypical pneumonia pathogens, using reverse transcription-polymerase chain reaction. Read More

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http://dx.doi.org/10.2147/IDR.S213296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679678PMC
July 2019
3 Reads

Ulcerative, granulomatous glossitis and enteritis caused by in a heifer.

J Vet Diagn Invest 2019 Sep 26;31(5):783-787. Epub 2019 Jul 26.

Veterinary Diagnostic Laboratory, Department of Veterinary Sciences, College of Agriculture Food & Environment, University of Kentucky, Lexington KY (Saied, Bolin).

infection in horses is common and is characterized by pyogranulomatous pneumonia and ulcerative enterocolitis. clinical disease in cattle, however, is rare and typically manifests as granulomatous lymphadenitis discovered in the abattoir. A 19-mo-old female Santa Gertrudis had a history of intermittent inappetence and weight loss for a 3-mo period before euthanasia. Read More

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http://dx.doi.org/10.1177/1040638719867120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727123PMC
September 2019
4 Reads

Therapeutic potential of lefamulin in the treatment of community-acquired pneumonia.

Future Microbiol 2019 07 23;14:927-939. Epub 2019 Jul 23.

Division of Geographic Medicine and Infectious Diseases, Tufts Medical Center, Boston, MA 02111, USA.

Despite the increasing availability of antibiotics with activity against pathogens that cause community-acquired pneumonia (CAP), CAP remains a major cause of morbidity, hospital admissions and re-admissions, and mortality. Lefamulin is a novel pleuromutilin antibiotic with potent activity against both typical and atypical CAP pathogens. In this review of the medical literature, we summarize the available information, including mounting clinical evidence, about lefamulin and its potential value in CAP. Read More

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http://dx.doi.org/10.2217/fmb-2019-0027DOI Listing
July 2019
3 Reads

Lung Microbiota and Pulmonary Inflammatory Cytokines Expression Vary in Children With Tracheomalacia and Adenoviral or Pneumonia.

Front Pediatr 2019 26;7:265. Epub 2019 Jun 26.

Department of Respiratory Diseases, Shenzhen Children's Hospital, Shenzhen, China.

Community-acquired pneumonia (CAP) is a worldwide infectious disease caused by bacteria, viruses, or a combination of these infectious agents. is an atypical pneumonia pathogen that causes high morbidity and mortality in children, and adenovirus can lead to severe pneumonia. However, the etiology of different types of pneumonia is still unclear. Read More

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http://dx.doi.org/10.3389/fped.2019.00265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611399PMC
June 2019
3 Reads

Etiology of Pulmonary Infections in Human Immunodeficiency Virus-infected Inpatients Using Sputum Multiplex Real-time Polymerase Chain Reaction.

Clin Infect Dis 2020 Mar;70(6):1147-1152

Division of Infectious Diseases and Human Immunodeficiency Virus Medicine, Department of Medicine, University of Cape Town, South Africa.

Background: There are limited data on the etiology of respiratory infections in human immunodeficiency virus (HIV)-infected patients in resource-limited settings.

Methods: We performed quantitative multiplex real-time polymerase chain reaction (PCR) for Pneumocystis jirovecii and common bacterial and viral respiratory pathogens on sputum samples (spontaneous or induced) from a prospective cohort study of HIV-infected inpatients with World Health Organization danger signs and cough. Mycobacterial culture was done on 2 sputum samples, blood cultures, and relevant extrapulmonary samples. Read More

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http://dx.doi.org/10.1093/cid/ciz332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108142PMC
March 2020
6 Reads

Evaluation of a molecular point-of-care testing for viral and atypical pathogens on intravenous antibiotic duration in hospitalized adults with lower respiratory tract infection: a randomized clinical trial.

Clin Microbiol Infect 2019 Nov 20;25(11):1415-1421. Epub 2019 Jun 20.

Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing, China; Institute of Respiratory Medicine, Chinese Academy of Medical Science, Beijing, China; National Clinical Research Centre of Respiratory Diseases, Beijing, China; Laboratory of Clinical Microbiology and Infectious Diseases, China-Japan Friendship Hospital, Beijing, China; Clinical Centre for Pulmonary Infections, Capital Medical University, Beijing, China; Tsinghua University-Peking University Joint Centre for Life Sciences, Beijing, China. Electronic address:

Objectives: The primary objective was to evaluate whether a molecular point-of-care test (POCT) for viral and atypical pathogens added to routine real-time PCR could reduce duration of intravenous antibiotics in hospitalized patients with lower respiratory tract infection (LRTI) compared with routine real-time PCR.

Methods: In this single-centre, open-label, randomized controlled study, we enrolled hospitalized adults diagnosed with LRTI. Patients were randomized to an intervention group (POCT FilmArray Panel for 20 viruses, atypical pathogens and bacteria plus routine real-time PCR) or a control group (routine real-time PCR for ten pathogens). Read More

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http://dx.doi.org/10.1016/j.cmi.2019.06.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173318PMC
November 2019
18 Reads

Pharmacokinetic/Pharmacodynamic Evaluation of Solithromycin against Streptococcus pneumoniae Using Data from a Neutropenic Murine Lung Infection Model.

Antimicrob Agents Chemother 2019 08 25;63(8). Epub 2019 Jul 25.

Department of Medicine, Section of Infectious Diseases, University of Wisconsin School of Medicine, Madison, Wisconsin, USA.

Solithromycin (CEM-101) is a novel fluoroketolide antimicrobial agent with activity against typical and atypical pathogens associated with community-acquired bacterial pneumonia. Using a neutropenic murine lung infection model, the objectives of this study were to identify the pharmacokinetic/pharmacodynamic (PK/PD) index most closely associated with efficacy and the magnitude of such indices associated with solithromycin efficacy against Plasma and epithelial lining fluid (ELF) samples for pharmacokinetics (PK) were collected serially over 24 hours from healthy mice administered single doses of solithromycin (0.625 to 40 mg/kg). Read More

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http://dx.doi.org/10.1128/AAC.02606-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658793PMC
August 2019
5 Reads

The Influence of National Guidelines on the Management of Community-Acquired Pneumonia in Children. Do Pediatricians Follow the Recommendations?

Adv Exp Med Biol 2019 ;1211:103-110

Department of Pediatric Pneumology and Allergy, Medical University of Warsaw, Warsaw, Poland.

This is a retrospective study whose main objective was to analyze the influence of the Polish Guidelines for the Management of Respiratory Tract Infections of 2010 (PGMRTI) on in-hospital treatment of children with community-acquired pneumonia (CAP). Files from four Warsaw hospitals were reviewed to identify children with uncomplicated CAP, treated before (2008-2009) (pre-PGMRTI) and after (2011-2012) (post-PGMRTI) publication of the guidelines. Predefined data on the management were compared. Read More

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http://dx.doi.org/10.1007/5584_2019_392DOI Listing
November 2019
2 Reads

Acquired acrodermatitis enteropathica due to zinc-depleted parenteral nutrition.

Pediatr Dermatol 2019 Jul 24;36(4):520-523. Epub 2019 May 24.

The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York.

Well-known causes of zinc deficiency, also referred to as acrodermatitis enteropathica (AE), include defects in intestinal zinc transporters and inadequate intake, but a rare cause of acquired zinc deficiency discussed here is an iatrogenic nutritional deficiency caused by parenteral nutrition administered without trace elements. While zinc-depleted parenteral nutrition causing dermatosis of acquired zinc deficiency was first reported in the 1990s, it is now again relevant due to a national vitamin and trace element shortage. A high index of suspicion may be necessary to diagnose zinc deficiency, particularly because early clinical findings are nonspecific. Read More

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http://dx.doi.org/10.1111/pde.13865DOI Listing
July 2019
8 Reads

What is the role of Ewingella americana in humans? A case report in a healthy 4-year-old girl.

BMC Infect Dis 2019 May 6;19(1):386. Epub 2019 May 6.

Università degli Studi di Milano, Milan, Italy.

Background: Ewingella americana (Ea) is a Gram-negative, lactose-fermenting, oxidase-negative and catalase-positive bacterium that was first described in 1983 as a new genus and species in the family Enterobacteriaceae. It is not known whether Ea is a true pathogen or simply an opportunistic infectious agent, as most of the cases have been described in patients at risk.

Case Presentation: A 4-year-old girl described here was hospitalized due to a productive cough over the previous 3 weeks and a fever > 38 °C associated with tachypnea over the previous 2 days. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-019-4021-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501419PMC
May 2019
20 Reads
2.613 Impact Factor

[Clinical features and reasons for missed diagnosis of allergic bronchopulmonary aspergillosis].

Zhonghua Yi Xue Za Zhi 2019 Apr;99(16):1221-1225

Department of Respiratory and Critical Care Medicine, Qilu Hospital of Shandong University, Jinan 250012, China.

To summarize the clinical features of allergic bronchopulmonary aspergillosis (ABPA) and analyze the common causes of missed diagnosis. The clinical data of patients with ABPA who were admitted into Qilu Hospital of Shandong University from October 2014 to November 2017 were retrospectively analyzed, including baseline data, eosinophil count in peripheral blood, serum total IgE, -specific antibody (sIgE, sIgG and sIgM), pulmonary function tests and chest CT, etc. Then the correlations between serum total IgE, sIgE and forced expiratory volume in one second (FEV) as percentage of predicted value (FEV%pred) was conducted, as well as that between serum total IgE, sIgE and FEV/forced vital capacity (FEV/FVC). Read More

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http://www.chinadoi.cn/portal/mr.action?doi=10.3760/cma.j.is
Publisher Site
http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.16.006DOI Listing
April 2019
9 Reads

Profiling of cellular immune responses to Mycoplasma pulmonis infection in C57BL/6 and DBA/2 mice.

Infect Genet Evol 2019 09 23;73:55-65. Epub 2019 Apr 23.

Laboratory of Laboratory Animal Science and Medicine, Department of Applied Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan. Electronic address:

Mycoplasma infections cause respiratory tract damages and atypical pneumonia, resulting in serious problems in humans and animals worldwide. It is well known that laboratory inbred mouse strains show various susceptibility to Mycoplasma pulmonis (M. pulmonis) infection, which causes murine respiratory mycoplasmosis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15671348193005
Publisher Site
http://dx.doi.org/10.1016/j.meegid.2019.04.019DOI Listing
September 2019
9 Reads

The extent of microbiological testing is associated with alteration of antibiotic therapy in adults with community-acquired pneumonia.

Eur J Clin Microbiol Infect Dis 2019 Jul 25;38(7):1359-1366. Epub 2019 Apr 25.

Department of Medical Microbiology and Immunology, St. Antonius Hospital, Nieuwegein, the Netherlands.

The aim of this study was to explore the relationship between the extent of microbiological testing and the frequency of antibiotic alteration in adults hospitalised with community-acquired pneumonia (CAP). We retrospectively studied 283 immunocompetent patients hospitalised with CAP. Information on microbiological testing and prescribed antibiotics was obtained. Read More

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http://dx.doi.org/10.1007/s10096-019-03561-8DOI Listing
July 2019
6 Reads

Atypical and Typical Bacteria in Children with Community Acquired Pneumonia.

Adv Exp Med Biol 2019 ;1160:65-71

Department of Basic Sciences, Wroclaw Medical University, Wroclaw, Poland.

This study seeks to determine the pathogens in respiratory specimens and blood serum obtained from children who present with community acquired pneumonia (CAP) diagnosed on the basis of clinical and radiological evidence. The study group consisted of 46 hospitalized children aged 1-11 years. The material for research consisted of pharyngeal swabs and samples of blood serum. Read More

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http://link.springer.com/10.1007/5584_2019_377
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http://dx.doi.org/10.1007/5584_2019_377DOI Listing
September 2019
16 Reads

Antibiotic Use and Respiratory Pathogens in Adults With Sickle Cell Disease and Acute Chest Syndrome.

Ann Pharmacother 2019 10 23;53(10):991-996. Epub 2019 Apr 23.

4 Medical University of South Carolina College of Pharmacy, Charleston, SC, USA.

Acute chest syndrome (ACS) is an acute complication of sickle cell disease (SCD). Historically, the most common pathogens were , and respiratory syncytial virus. Pediatric patients receiving guideline-adherent therapy experienced fewer ACS-related and all-cause 30-day readmissions compared with those receiving nonadherent therapy. Read More

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http://dx.doi.org/10.1177/1060028019846118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7207009PMC
October 2019
9 Reads
2.059 Impact Factor

Multi-organ failure induced by Nivolumab in the context of allo-stem cell transplantation.

Exp Hematol Oncol 2019 28;8. Epub 2019 Mar 28.

1Institute for Advanced Biosciences, Université Grenoble Alpes, INSERM 1209, UMR CNRS 5309, Grenoble, France.

Background: Immune checkpoint inhibitors have radically changed the landscape of anti-tumor therapies in several malignancies. However the adverse events associated with immune checkpoint blockade in combination with other treatments remains to be thoroughly documented. Here we report the case of a 33-year-old male with classical Hodgkin lymphoma who was successfully treated for lymphoma but experienced serious and eventually fatal multisystem organ failure following nivolumab administration and allogeneic stem cell transplantation. Read More

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http://dx.doi.org/10.1186/s40164-019-0132-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437980PMC
March 2019
17 Reads

Omadacycline: A New Tetracycline Antibiotic.

Ann Pharmacother 2019 05 7;53(5):486-500. Epub 2018 Dec 7.

3 Denver Health Medical Center, Denver, CO, USA.

Objective: To review the chemistry, pharmacology, microbiology, pharmacokinetics, pharmacodynamics, clinical efficacy, tolerability, dosage, and administration of omadacycline, a new tetracycline antibiotic.

Data Sources: A literature search through PubMed, Google Scholar, and clinicaltrials.gov was conducted (2008 to October 2018) using the search terms omadacycline and PTK-0796. Read More

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http://dx.doi.org/10.1177/1060028018818094DOI Listing
May 2019
7 Reads