1,519 results match your criteria Pneumonia Atypical Bacterial


Multi-organ failure induced by Nivolumab in the context of allo-stem cell transplantation.

Exp Hematol Oncol 2019 28;8. Epub 2019 Mar 28.

1Institute for Advanced Biosciences, Université Grenoble Alpes, INSERM 1209, UMR CNRS 5309, Grenoble, France.

Background: Immune checkpoint inhibitors have radically changed the landscape of anti-tumor therapies in several malignancies. However the adverse events associated with immune checkpoint blockade in combination with other treatments remains to be thoroughly documented. Here we report the case of a 33-year-old male with classical Hodgkin lymphoma who was successfully treated for lymphoma but experienced serious and eventually fatal multisystem organ failure following nivolumab administration and allogeneic stem cell transplantation. Read More

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http://dx.doi.org/10.1186/s40164-019-0132-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437980PMC
March 2019
1 Read

Omadacycline: A New Tetracycline Antibiotic.

Ann Pharmacother 2019 May 7;53(5):486-500. Epub 2018 Dec 7.

3 Denver Health Medical Center, Denver, CO, USA.

Objective: To review the chemistry, pharmacology, microbiology, pharmacokinetics, pharmacodynamics, clinical efficacy, tolerability, dosage, and administration of omadacycline, a new tetracycline antibiotic.

Data Sources: A literature search through PubMed, Google Scholar, and clinicaltrials.gov was conducted (2008 to October 2018) using the search terms omadacycline and PTK-0796. Read More

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http://dx.doi.org/10.1177/1060028018818094DOI Listing
May 2019
1 Read

Computational screening of potential drug targets for pathogens causing bacterial pneumonia.

Microb Pathog 2019 May 23;130:271-282. Epub 2019 Mar 23.

Department of Biotechnology, Thapar Institute of Engineering & Technology, Patiala, Punjab 147004, India. Electronic address:

Streptococcus pneumoniae is widely recognized as the main cause of bacterial pneumonia among all age groups. Other important gram-positive, gram-negative and atypical bacteria causing pneumonia majorly infect children and infants. Despite abundant occurrence of bacterial pneumonia, there is no specific antibiotic therapy available. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.03.024DOI Listing
May 2019
1 Read
2.000 Impact Factor

[Human Psittacosis: A Case Report].

Acta Med Port 2019 Feb 28;32(2):161-164. Epub 2019 Feb 28.

Serviço de Doenças Infeciosas. Centro Hospitalar do Porto. Porto. Portugal.

Psittacosis is a rare disease caused by Chlamydophila psittaci, an intracellular bacteria transmitted by contaminated birds. The clinical and radiological presentations are nonspecific. We describe a case of a 42-year-old woman, with known exposure to birds, who presented to the emergency department with one-week evolution of myalgia, polyarthritis, and respiratory symptoms. Read More

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http://dx.doi.org/10.20344/amp.10079DOI Listing
February 2019
1 Read

[Features of community-acquired pneumonia in immunocompetent hospitalized adults according to the causal agent].

Rev Med Chil 2018 Dec;146(12):1371-1383

Departamento de Enfermedades Respiratorias, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

Background: Molecular biological techniques allow the identification of more pathogens associated with community-acquired pneumonia (CAP).

Aim: To compare clinical and laboratory parameters of patients with CAP caused by different groups of pathogens.

Material And Methods: In a prospective study, immunocompetent adult patients hospitalized with CAP were tested for the presence of a broad range of possible respiratory pathogens using bacterial cultures, polymerase chain reaction, urinary antigen testing and serology. Read More

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http://dx.doi.org/10.4067/s0034-98872018001201371DOI Listing
December 2018
5 Reads

Guideline Adherence in Diagnostic Testing and Treatment of Community-Acquired Pneumonia in Children.

Pediatr Emerg Care 2019 Feb 14. Epub 2019 Feb 14.

Ann and Robert H Lurie Children's Hospital, Feinberg School of Medicine, Northwestern University, Chicago, IL.

Objectives: The objective of this study was to determine emergency department (ED) physician adherence with the 2011 Pediatric Infectious Diseases Society (PIDS) and Infectious Diseases Society of America (IDSA) guidelines for outpatient management of children with mild-to-moderate community-acquired pneumonia (CAP).

Methods: A cross-sectional survey of physicians on the American Academy of Pediatrics Section on Emergency Medicine Survey listserv was conducted. We evaluated ED physicians' reported adherence with the PIDS/IDSA guidelines through presentation of 4 clinical vignettes representing mild-to-moderate CAP of presumed viral (preschool-aged child), bacterial (preschool and school-aged child), and atypical bacterial (school-aged child) etiology. Read More

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http://dx.doi.org/10.1097/PEC.0000000000001745DOI Listing
February 2019
2 Reads

The use of multiplex PCR for the detection of atypical pathogens in Egyptian children with CAP: a high rate of in early infancy.

J Egypt Public Health Assoc 2019 18;94(1). Epub 2019 Jan 18.

2Department of Clinical Pathology, Faculty of Medicine, Cairo University, 2 Atteia Abd El Hadi St., El Maadi, Cairo, 11562 Egypt.

Background: Atypical pathogen infections played an important role in community-acquired pneumonia (CAP) in children. Pathogen-specific clinical symptoms are often lacking, and it is difficult to detect atypical pathogens by culture methods. The use of multiplex polymerase chain reaction (PCR) methods enables testing for many pathogens simultaneously in a single analysis. Read More

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http://dx.doi.org/10.1186/s42506-018-0003-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338716PMC
April 2019
9 Reads

Persistence: A Survival Strategy to Evade Antimicrobial Effects and .

Front Microbiol 2018 12;9:3101. Epub 2018 Dec 12.

CIBICI-CONICET, Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina.

The comprise a group of highly adapted bacterial pathogens sharing a unique intracellular lifestyle. Three species are pathogenic to humans: , and . is the leading bacterial cause of sexually-transmitted infections and infectious blindness worldwide. Read More

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http://dx.doi.org/10.3389/fmicb.2018.03101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299033PMC
December 2018
3 Reads

Implementation of Point-of-Care Molecular Diagnostics for Mycoplasma pneumoniae Ensures the Correct Antimicrobial Prescription for Pediatric Pneumonia Patients.

Tohoku J Exp Med 2018 12;246(4):225-231

Department of Pediatrics, Tsukuba Medical Center Hospital.

Mycoplasma pneumoniae is a leading causative pathogen of pneumonia among pediatric patients, and its accurate diagnosis may aid in the selection of appropriate antimicrobial agents. We established a rapid reporting system of a polymerase chain reaction (PCR) examination for M. pneumoniae that enables physicians to obtain test results approximately 90 minutes after ordering the test. Read More

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http://dx.doi.org/10.1620/tjem.246.225DOI Listing
December 2018

[Epidemiological investigation and analysis of an outbreak of mycoplasma pneumoniae pneumonia in adult].

Zhonghua Yi Xue Za Zhi 2018 Dec;98(46):3784-3788

Graduate College of Fujian Medical University, Fuzhou 350108, China.

To conduct an epidemiological investigation and analysis of an outbreak of mycoplasma pneumonia in adults. The first case was a 23-year-old male came from the Third Military Medical University, who served as an intern in the Fuzhou General Hospital of PLA and presented on July 16, 2015 with a history of low-grade fever, dizziness, fatigue and chest tightness. Chest CT revealed pulmonary nodules shadow. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2018.46.012DOI Listing
December 2018

Clinical management of community-acquired pneumonia in young children.

Expert Opin Pharmacother 2019 03 3;20(4):435-442. Epub 2018 Dec 3.

b Department of Pediatrics , Federal University of Bahia School of Medicine , Salvador , Brazil.

Introduction: Community-acquired pneumonia (CAP) is the leading cause of mortality among children under 5 years worldwide. However, the choices of chemical therapy for the empirical treatment of CAP are frequently debated.

Areas Covered: The authors provide an update on the chemical management recommendations for childhood CAP. Read More

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https://www.tandfonline.com/doi/full/10.1080/14656566.2018.1
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http://dx.doi.org/10.1080/14656566.2018.1552257DOI Listing
March 2019
28 Reads

Community acquired pneumonia among adult patients at an Egyptian university hospital: bacterial etiology, susceptibility profile and evaluation of the response to initial empiric antibiotic therapy.

Infect Drug Resist 2018 2;11:2141-2150. Epub 2018 Nov 2.

Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Background: Effective empirical antibiotic therapy for community acquired pneumonia (CAP), based on frequently updated data about the pattern of bacterial distribution and their antimicrobial susceptibilities, is mandatory.

Aim: To identify the bacterial etiology of CAP in adults and their antibiotic susceptibility patterns and to evaluate the response to initial empirical antibiotic therapy in an Egyptian university hospital.

Settings And Design: A cross-sectional hospital-based study. Read More

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http://dx.doi.org/10.2147/IDR.S182777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223388PMC
November 2018
37 Reads

Omadacycline Enters the Ring: A New Antimicrobial Contender.

Pharmacotherapy 2018 Dec 15;38(12):1194-1204. Epub 2018 Nov 15.

Department of Pharmacy Practice, University of Mississippi School of Pharmacy, Jackson, Mississippi.

Omadacycline is a novel aminomethylcycline approved for the treatment of community-acquired bacterial pneumonia and acute bacterial skin and skin structure infections. This article reviews existing data pertaining to the biochemistry, mechanism of action, pharmacokinetics/pharmacodynamics, in vitro activity, and current progress with omadacycline in clinical trials. Omadacycline inhibits protein synthesis by binding to the 30S subunit of the bacterial ribosome at the tetracycline-binding site with an affinity similar to glycylcyclines. Read More

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http://dx.doi.org/10.1002/phar.2185DOI Listing
December 2018
5 Reads

Transcriptional regulation of galF by RcsAB affects capsular polysaccharide formation in Klebsiella pneumoniae NTUH-K2044.

Microbiol Res 2018 Nov 25;216:70-78. Epub 2018 Aug 25.

School of Public Health and Management, Chongqing Medical University, Chongqing, China. Electronic address:

RcsAB is an atypical two-component regulatory system that can regulate exopolysaccharide biosynthesis and is involved in the virulence of K. pneumoniae. The gene galF is well known as a gene involved in the biosynthesis of capsular polysaccharide (CPS). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09445013183024
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http://dx.doi.org/10.1016/j.micres.2018.08.010DOI Listing
November 2018
4 Reads

Bronchopneumonia in Swedish lambs: a study of pathological changes and bacteriological agents.

Acta Vet Scand 2018 Sep 17;60(1):54. Epub 2018 Sep 17.

Department of Biomedical Sciences and Veterinary Public Health, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences (Ulls väg 26), 757 56, Uppsala, Sweden.

Background: One of the most common post-mortem inspection finding of sheep and lambs in Sweden, following routine slaughter is pneumonia and its prevalence is increasing. To our knowledge, the aetiology of pneumonia in lambs is not well-known for Swedish conditions. Chronic bronchopneumonia, also known as "atypical" or chronic non-progressive pneumonia, is a common disease worldwide, affecting lambs up to 12 months old. Read More

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http://dx.doi.org/10.1186/s13028-018-0409-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142326PMC
September 2018
7 Reads

A patient full of surprises: a body packer with cocaine intoxication, pneumococcal pneumonia and HIV infection.

BMC Emerg Med 2018 09 4;18(1):29. Epub 2018 Sep 4.

Emergency Department, University Hospital Zurich, Rämistrasse 100, 8091, Zurich, Switzerland.

Background: Smuggling of illegal drugs by hiding them inside one's own body, also called body packing, is a worldwide phenomenon. Cocaine is the most frequently transported drug. Body packing is a potentially lethal practice. Read More

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http://dx.doi.org/10.1186/s12873-018-0180-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123965PMC
September 2018
9 Reads

Icelandic ovine Mycoplasma ovipneumoniae are variable bacteria that induce limited immune responses in vitro and in vivo.

J Med Microbiol 2018 Oct 16;67(10):1480-1490. Epub 2018 Aug 16.

1​Institute for Experimental Pathology, University of Iceland, Keldur, Keldnavegur 3, 112 Reykjavik, Iceland.

Purpose: Mycoplasma ovipneumoniae is a pathogen that causes atypical pneumoniae in sheep and goats. While infection of lambs can induce strong immune responses, typically measured as serum antibodies, experimental vaccines appear to induce lower antibody titres. The purpose of this study was to better understand the bacterium and its interaction with the host, in order to improve the vaccination strategy. Read More

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http://dx.doi.org/10.1099/jmm.0.000818DOI Listing
October 2018
1 Read

Severe atypical pneumonia in critically ill patients: a retrospective multicenter study.

Ann Intensive Care 2018 Aug 13;8(1):81. Epub 2018 Aug 13.

AP-HP, Medical ICU, Hôpital Saint-Louis, 1 Avenue Claude Vellefaux, 75010, Paris, France.

Background: Chlamydophila pneumoniae (CP) and Mycoplasma pneumoniae (MP) patients could require intensive care unit (ICU) admission for acute respiratory failure.

Methods: Adults admitted between 2000 and 2015 to 20 French ICUs with proven atypical pneumonia were retrospectively described. Patients with MP were compared to Streptococcus pneumoniae (SP) pneumonia patients admitted to ICUs. Read More

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http://dx.doi.org/10.1186/s13613-018-0429-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089852PMC
August 2018
4 Reads

Mycoplasma pneumoniae DNA detection and specific antibody class response in patients from two tertiary care hospitals in tropical Sri Lanka.

J Med Microbiol 2018 Sep 3;67(9):1232-1242. Epub 2018 Aug 3.

1​Department of Medical Microbiology, Faculty of Medicine, University of Kelaniya, Sri Lanka.

Purpose: Respiratory tract infections are a major cause of global morbidity and mortality. Pneumonia is the ninth leading cause of mortality in Sri Lanka. Atypical pathogens cause about one-fifth of community-acquired pneumonia, while Mycoplasma pneumoniae accounts for about 50 %. Read More

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http://dx.doi.org/10.1099/jmm.0.000813DOI Listing
September 2018
16 Reads

Rapid Detection of Respiratory Pathogens for Community-Acquired Pneumonia by Capillary Electrophoresis-Based Multiplex PCR.

SLAS Technol 2019 02 26;24(1):105-116. Epub 2018 Jul 26.

1 Department of Laboratory Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Community-acquired pneumonia (CAP) is a common infectious disease linked to high rates of morbidity and mortality. Fast and accurate identification of the pathogens responsible for CAP will aid in diagnosis. We established a capillary electrophoresis-based multiplex PCR (CEMP) panel to enable the detection of viral and bacterial pathogens associated with CAP. Read More

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http://journals.sagepub.com/doi/10.1177/2472630318787452
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http://dx.doi.org/10.1177/2472630318787452DOI Listing
February 2019
7 Reads

Lefamulin: Review of a Promising Novel Pleuromutilin Antibiotic.

Pharmacotherapy 2018 Sep 20;38(9):935-946. Epub 2018 Aug 20.

Department of Pharmacy Practice, University of Mississippi, Jackson, Mississippi.

The emergence and spread of antimicrobial resistance have led to a global public health emergency requiring development of new antimicrobial classes. Lefamulin (formally BC-3781) is a novel pleuromutilin antibiotic currently undergoing Food and Drug Administration review for community-acquired bacterial pneumonia (CABP) as intravenous (IV) and oral (PO) formulations. Although pleuromutilin antibiotics were first developed in the 1950s, lefamulin is the first to be used for systemic treatment of bacterial infections in humans. Read More

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http://dx.doi.org/10.1002/phar.2166DOI Listing
September 2018
49 Reads

An atypical case of atypical pneumonia.

J Gen Fam Med 2018 Jul 3;19(4):133-135. Epub 2018 Jun 3.

Department of Emergency Medicine Osaka Medical College Takatsuki Japan.

Atypical pneumonia has been thought to account for 7%-20% of community-acquired pneumonia (CAP). The treatment for the pathogens that cause atypical pneumonia is different from that of other bacterial pneumonia. Therefore, identification of the causative pathogen in a primary care situation is crucial for adequate treatment of CAP. Read More

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http://dx.doi.org/10.1002/jgf2.179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030032PMC
July 2018
3 Reads

Community-acquired bacterial pneumonia in adult HIV-infected patients.

Expert Rev Anti Infect Ther 2018 07 12;16(7):579-588. Epub 2018 Jul 12.

a Department of Pulmonary Medicine Institut Clinic del Tórax, Hospital Clinic of Barcelona - Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) , University of Barcelona (UB) - SGR 911- Ciber de Enfermedades Respiratorias (Ciberes) , Barcelona , Spain.

Introduction: Despite active antiretroviral therapy (ART), community-acquired pneumonia (CAP) remains a major cause of morbidity and mortality among human immunodeficiency virus (HIV)-infected patients and incurs high health costs. Areas covered: This article reviews the most recent publications on bacterial CAP in the HIV-infected population, focusing on epidemiology, prognostic factors, microbial etiology, therapy, and prevention. The data discussed here were mainly obtained from a non-systematic review using Medline, and references from relevant articles. Read More

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http://dx.doi.org/10.1080/14787210.2018.1495560DOI Listing
July 2018
3 Reads

Chronic Granulomatous Disease First Diagnosed in Adulthood Presenting With Spinal Cord Infection.

Front Immunol 2018 4;9:1258. Epub 2018 Jun 4.

Department of Neurology, Hannover Medical School, Hannover, Germany.

Chronic granulomatous disease (CGD) is a rare genetic immunodeficiency, which is characterized by recurrent severe bacterial and fungal infections caused by a defect in phagocytic cells due to loss of superoxide production. The disease usually manifests within the first years of life. Early diagnosis allows therapeutic intervention to improve the limited life expectancy. Read More

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http://dx.doi.org/10.3389/fimmu.2018.01258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994559PMC
June 2018
22 Reads

Sialylated Receptor Setting Influences Mycoplasma pneumoniae Attachment and Gliding Motility.

Mol Microbiol 2018 09 30;109(6):735-744. Epub 2018 Sep 30.

Department of Microbiology, University of Georgia, Athens, Georgia, USA.

Mycoplasma pneumoniae is a common cause of human respiratory tract infections, including bronchitis and atypical pneumonia. M. pneumoniae binds glycoprotein receptors having terminal sialic acid residues via the P1 adhesin protein. Read More

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http://dx.doi.org/10.1111/mmi.13997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185809PMC
September 2018
27 Reads

Macrolide Resistance in Cases of Community-Acquired Bacterial Pneumonia in the Emergency Department.

J Emerg Med 2018 09 19;55(3):347-353. Epub 2018 May 19.

Department of Emergency Medicine, University of Massachusetts Medical School, UMass Memorial Medical Group, Worcester, Massachusetts.

Background: Emergency physicians are under pressure to prescribe an antibiotic early in the treatment course of a patient with community-acquired pneumonia (CAP). Macrolides are recommended first-line empirical therapy for the outpatient treatment of CAP in patients without associated comorbidities; however, resistance rates to macrolides in the United States are on the rise.

Objective: This review considers macrolide use for CAP in the emergency department by reviewing the microbiologic environment in the United States and whether macrolides can overcome in vitro resistance during actual clinical use. Read More

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http://dx.doi.org/10.1016/j.jemermed.2018.04.031DOI Listing
September 2018
2 Reads

High flux isothermal assays on the pathogenic features of Mycoplasma pneumoniae.

Microb Pathog 2018 Jul 4;120:219-222. Epub 2018 May 4.

Department of Laboratory Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou 510120, China. Electronic address:

As one of the most important pathogens, M. pneumoniae is a causative agent responsible for atypical and other respiratory tract infections, even its extra-pulmonary complications. This study aims to use the high and rapid flux sequencing assays on the M. Read More

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http://dx.doi.org/10.1016/j.micpath.2018.05.004DOI Listing
July 2018
2 Reads

An unusual presentation of a case of human psittacosis.

Respir Med Case Rep 2018 2;23:138-142. Epub 2018 Feb 2.

Dept. of Respiratory Medicine, Ghent University Hospital, Corneel Heymanslaan 10, B-9000, Ghent, Belgium.

Background: is a gram-negative, obligate intracellular organism. Birds are the main reservoir, but also non-avian domestic animals and humans can be infected. In humans it mostly causes respiratory infections due to occupational exposure with varying severity. Read More

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http://dx.doi.org/10.1016/j.rmcr.2018.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926501PMC
February 2018
11 Reads

A recombinase polymerase amplification assay for the diagnosis of atypical pneumonia.

Anal Biochem 2018 06 18;550:54-60. Epub 2018 Apr 18.

Fraunhofer Institute for Cell Therapy and Immunology, Branch Bioanalytics and Bioprocesses (Fraunhofer IZI-BB), Germany.

Pneumonia is one of the most common and potentially lethal infectious conditions worldwide. Streptococcus pneumoniae is the pathogen most frequently associated with bacterial community-acquired pneumonia, while Legionella pneumophila is the major cause for local outbreaks of legionellosis. Both pathogens can be difficult to diagnose since signs and symptoms are nonspecific and do not differ from other causes of pneumonia. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00032697183040
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http://dx.doi.org/10.1016/j.ab.2018.04.014DOI Listing
June 2018
3 Reads

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome associated with cefotaxime and clindamycin use in a 6 year-old boy: a case report.

Pan Afr Med J 2017 9;28:218. Epub 2017 Nov 9.

Healthy Sciences University, Umraniye Training and Research Hospital, Department of Pediatrics, Istanbul, Turkey.

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare and potentially life-threatening idiosyncratic drug reaction. It presents with extensive rash, fever, lymphadenopathy, hematologic abnormalities (eosinophilia and/or atypical lymphocytosis) and internal organ involvement. It has been described in association with more than 50 drugs. Read More

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http://dx.doi.org/10.11604/pamj.2017.28.218.10828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881561PMC
May 2018
10 Reads

The unprecedented 2014 Legionnaires' disease outbreak in Portugal: atmospheric driving mechanisms.

Int J Biometeorol 2018 Jul 23;62(7):1167-1179. Epub 2018 Mar 23.

Instituto Dom Luiz, Faculdade de Ciências da Universidade de Lisboa, Campo Grande, Edifício C1, Piso 1, 1749-016, Lisbon, Portugal.

A large outbreak of Legionnaires' disease occurred in November 2014 nearby Lisbon, Portugal. This epidemic infected 377 individuals by the Legionella pneumophila bacteria, resulting in 14 deaths. The primary source of transmission was contaminated aerosolized water which, when inhaled, lead to atypical pneumonia. Read More

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http://dx.doi.org/10.1007/s00484-018-1520-8DOI Listing
July 2018
5 Reads

Early predictors of unresponsiveness to high-flow nasal cannula therapy in a pediatric emergency department.

Pediatr Pulmonol 2018 Jun 12;53(6):809-815. Epub 2018 Mar 12.

Division of Pediatric Emergency Medicine, Dokuz Eylul University, School of Medicine, Izmir, Turkey.

Aim: High-flow nasal cannula (HFNC) is a new treatment option for pediatric respiratory distress and we aimed to assess early predictive factors of unresponsiveness to HFNC therapy in a pediatric emergency department (ED).

Method: Patients who presented with respiratory distress and were treated by HFNC, were included. The age, gender, weight, medical history, diagnosis, vital signs, oxygen saturation/fraction of inspired oxygen (SpO /FiO ) ratio, modified Respiratory Distress Assessment Instrument (mRDAI) scores, medical interventions, duration of HFNC therapy, time to escalation, adverse effects, and laboratory test results were obtained from medical and nursing records. Read More

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http://dx.doi.org/10.1002/ppul.23981DOI Listing
June 2018
9 Reads

A Comparison of the Efficacy and Safety of Intravenous Followed by Oral Delafloxacin With Vancomycin Plus Aztreonam for the Treatment of Acute Bacterial Skin and Skin Structure Infections: A Phase 3, Multinational, Double-Blind, Randomized Study.

Clin Infect Dis 2018 Aug;67(5):657-666

Melinta Therapeutics, Lincolnshire, Illinois.

Background: Delafloxacin is an intravenous (IV)/oral anionic fluoroquinolone with activity against gram-positive (including methicillin-resistant Staphylococcus aureus [MRSA]), gram-negative, atypical, and anaerobic organisms. It is approved in the United States for acute bacterial skin and skin structure infections (ABSSSIs) caused by designated susceptible gram-positive and gram-negative organisms, and is in development for the treatment of community-acquired bacterial pneumonia.

Methods: A multicenter, randomized, double-blind trial of 850 adults with ABSSSI compared delafloxacin 300 mg IV every 12 hours for 3 days with a switch to 450 mg oral delafloxacin, to vancomycin 15 mg/kg IV with aztreonam for 5-14 days. Read More

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http://dx.doi.org/10.1093/cid/ciy165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093995PMC
August 2018
6 Reads

Aetiology of lower respiratory tract infection in adults in primary care: a prospective study in 11 European countries.

Clin Microbiol Infect 2018 Nov 12;24(11):1158-1163. Epub 2018 Feb 12.

Department of Medical Microbiology, Antwerp University Hospital, Antwerp, Belgium; Vaccine & Infectious Disease Institute (VAXINFECTIO), University of Antwerp, Antwerp, Belgium.

Objectives: To describe the role of bacteria (including bacterial resistance), viruses (including those recently described) and mixed bacterial-viral infections in adults presenting to primary care with lower respiratory tract infection (LRTI).

Methods: In all, 3104 adults with LRTI were enrolled, of whom 141 (4.5%) had community-acquired pneumonia (CAP), and 2985 matched controls in a prospective study in 16 primary care networks in Europe, and followed patients up at 28-35 days. Read More

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http://dx.doi.org/10.1016/j.cmi.2018.02.004DOI Listing
November 2018
6 Reads

Bacterial Pneumonia in Elderly Japanese Populations.

Jpn Clin Med 2018 3;9:1179670717751433. Epub 2018 Jan 3.

Department of Respiratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Bacterial pneumonia is one of the most important infectious diseases in terms of incidence, effect on quality of life, mortality, and impact on society. Pneumonia was the third leading cause of death in Japan in 2011. In 2016, 119 650 Japanese people died of pneumonia, 96% of whom were aged 65 years and above. Read More

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http://dx.doi.org/10.1177/1179670717751433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5804998PMC
January 2018
1 Read

Detection of respiratory bacterial pathogens causing atypical pneumonia by multiplex Lightmix RT-PCR.

Int J Med Microbiol 2018 Apr 31;308(3):317-323. Epub 2018 Jan 31.

Institute of Medical Microbiology, University of Zurich, Switzerland. Electronic address:

Pneumonia is a severe infectious disease. In addition to common viruses and bacterial pathogens (e.g. Read More

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http://dx.doi.org/10.1016/j.ijmm.2018.01.010DOI Listing
April 2018
5 Reads

A Case of Macrolide-Refractory Pneumonia in Pregnancy Treated with Garenoxacin.

Case Rep Obstet Gynecol 2017 10;2017:3520192. Epub 2017 Dec 10.

Department of Gynecology and Obstetrics, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan.

Pneumonia in pregnancy is associated with adverse maternal and foetal outcomes, and intensive treatment with appropriate antibiotics is essential. However, cases caused by pathogens that are resistant to antibiotics suitable for the developing foetus are challenging. We herein report a case of macrolide-refractory pneumonia in pregnancy. Read More

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http://dx.doi.org/10.1155/2017/3520192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742429PMC
December 2017
22 Reads

Community-Acquired Respiratory Distress Syndrome Toxin Uses a Novel KELED Sequence for Retrograde Transport and Subsequent Cytotoxicity.

MBio 2018 01 23;9(1). Epub 2018 Jan 23.

Department of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA

is an atypical bacterium that causes respiratory illnesses in humans, including pharyngitis, tracheobronchitis, and community-acquired pneumonia (CAP). It has also been directly linked to reactive airway disease, asthma, and extrapulmonary pathologies. During its colonization, expresses a unique ADP-ribosylating and vacuolating cytotoxin designated ommunity-cquired espiratory istress yndrome (CARDS) toxin. Read More

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http://dx.doi.org/10.1128/mBio.01663-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784248PMC
January 2018
7 Reads

The First Serological Study of Q Fever in Humans in Lebanon.

Vector Borne Zoonotic Dis 2018 03 16;18(3):138-143. Epub 2018 Jan 16.

2 Doctoral School of Sciences and Technology, Lebanese University , Beirut, Lebanon .

Objective: The aim of this study was to estimate, for the first time, the human seroprevalence of Q fever in Lebanon, by assessing the presence of antibodies against the causative agent, Coxiella burnetii. A total number of 421 serum samples (226 females and 196 males) were collected in February 2015 from hospitals and laboratories dispersed in five Lebanese provinces: Akkar, Bekaa, Mount Lebanon, Nabatieh, and South Lebanon.

Methods: Serial testing approach was used. Read More

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http://dx.doi.org/10.1089/vbz.2016.2102DOI Listing
March 2018
35 Reads

Epidemiology of Respiratory Pathogens in Children with Lower Respiratory Tract Infections in Shanghai, China, from 2013 to 2015.

Jpn J Infect Dis 2018 Jan 26;71(1):39-44. Epub 2017 Dec 26.

Department of Clinical Laboratory, Children's Hospital of Fudan University.

This study aimed to explore the epidemiology of pathogens in children who were hospitalized with lower respiratory tract infections (LRTIs) at the Children's Hospital of Fudan University, Shanghai, China. Children aged less than 18 years who were hospitalized with LRTIs were enrolled from January 2013 to December 2015. Respiratory specimens were collected for the detection of common respiratory viruses, atypical bacteria, and other bacteria using current laboratory diagnostic tests. Read More

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http://dx.doi.org/10.7883/yoken.JJID.2017.323DOI Listing
January 2018
14 Reads
1.204 Impact Factor

Spotlight on solithromycin in the treatment of community-acquired bacterial pneumonia: design, development, and potential place in therapy.

Drug Des Devel Ther 2017 13;11:3559-3566. Epub 2017 Dec 13.

Department of Pharmacy, Corpus Christi Medical Center, Corpus Christi, TX.

Community-acquired bacterial pneumonia (CABP) is a leading cause of death worldwide. However, antibacterial agents used to treat common pathogens in CABP are marked by adverse drug events and increasing antimicrobial resistance. Solithromycin is a new ketolide antibiotic, based on the macrolide antibiotic structure, being studied for use in CABP. Read More

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http://dx.doi.org/10.2147/DDDT.S119545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732564PMC
August 2018
11 Reads

Recovery from childhood community-acquired pneumonia in a developing country: Prognostic value of serum procalcitonin.

Clin Chim Acta 2019 Feb 16;489:212-218. Epub 2017 Dec 16.

Postgraduate Program in Health Sciences, Federal University of Bahia School of Medicine, Salvador, Brazil; Department of Pediatrics, Federal University of Bahia School of Medicine, Salvador, Brazil.

Background: Childhood community-acquired pneumonia is a common and potentially life-threatening illness in developing countries. We assessed the prognostic value of serum procalcitonin level upon admission on clinical response to antibiotic treatment.

Methods: Out of 89 patients, the median (IQR) age was 19(12-29) months and 60% were boys. Read More

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http://dx.doi.org/10.1016/j.cca.2017.12.021DOI Listing
February 2019
14 Reads

Serological study of Bordetella Pertussis, Mycoplasma Pneumonia and Chlamydia Pneumonia in Iranian hajj pilgrims with prolonged cough illnesses: A follow-up study.

Respir Med 2017 Nov 13;132:122-131. Epub 2017 Oct 13.

Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Electronic address:

Introduction: Hajj pilgrimage is the biggest and longest mass gathering in the Muslim world. Annually, about 50% of more than 2.5 million pilgrims participating in this ritual get involved in severe devastating coughs. Read More

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http://dx.doi.org/10.1016/j.rmed.2017.10.009DOI Listing
November 2017
8 Reads

[Etiological analysis and establishment of a discriminant model for lower respiratory tract infections in hospitalized patients].

Zhonghua Jie He He Hu Xi Za Zhi 2017 Dec;40(12):909-914

The Department of Respiratory and Critical Care Medicine, Fujian Province Hospital, Fuzhou 350001, China.

To analyze the pathogens of lower respiratory tract infection(LRTI) including bacterial, viral and mixed infection, and to establish a discriminant model based on clinical features in order to predict the pathogens. A total of 243 hospitalized patients with lower respiratory tract infections were enrolled in Fujian Provincial Hospital from April 2012 to September 2015. The clinical data and airway (sputum and/or bronchoalveolar lavage) samples were collected. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1001-0939.2017.12.009DOI Listing
December 2017
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From genomes to genotypes: molecular epidemiological analysis of Chlamydia gallinacea reveals a high level of genetic diversity for this newly emerging chlamydial pathogen.

BMC Genomics 2017 Dec 6;18(1):949. Epub 2017 Dec 6.

Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University College of Veterinary Medicine, Yangzhou, Jiangsu, 225009, People's Republic of China.

Background: Chlamydia (C.) gallinacea is a recently identified bacterium that mainly infects domestic chickens. Demonstration of C. Read More

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http://dx.doi.org/10.1186/s12864-017-4343-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717833PMC
December 2017
22 Reads

Molecular etiological profile of atypical bacterial pathogens, viruses and coinfections among infants and children with community acquired pneumonia admitted to a national hospital in Lima, Peru.

BMC Res Notes 2017 Dec 6;10(1):688. Epub 2017 Dec 6.

Barcelona Research Center for Multiscale Science and Engineering, Departament d'Enginyeria Quıímica, EEBE, Universitat Politècnica de Catalunya (UPC), Barcelona Tech, C/Eduard Maristany, 10-14, Ed. I2, 08019, Barcelona, Spain.

Objective: The main objective of this study was to detect the presence of 14 respiratory viruses and atypical bacteria (Mycoplasma pneumoniae, Chlamydia pneumoniae), via polymerase chain reaction in patients under 18 years old hospitalized due to community-acquired pneumonia (CAP) from Lima, Peru.

Results: Atypical pathogens were detected in 40% (58/146); viral etiologies in 36% (52/146) and coinfections in 19% (27/146). The most common etiological agent was M. Read More

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http://dx.doi.org/10.1186/s13104-017-3000-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718007PMC
December 2017
48 Reads

Acute disseminated melioidosis giving rise to pneumonia and renal abscesses complicated with thrombotic thrombocytopenic purpura in a post partum woman: a case report.

BMC Res Notes 2017 Nov 29;10(1):653. Epub 2017 Nov 29.

Teaching Hospital Karapitiya, Galle, Sri Lanka.

Background: Melioidosis is an established endemic infection in Sri Lanka, caused by Burkholderia pseudomallei, a gram negative bacterium distributed in saprophytes in soil and surface water. Main mode of transmission is via percutaneous inoculation. Pneumonia is the most common presentation in acute disease. Read More

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https://bmcresnotes.biomedcentral.com/articles/10.1186/s1310
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http://dx.doi.org/10.1186/s13104-017-2997-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708086PMC
November 2017
10 Reads

Systemic cytokines and chemokines on admission of children hospitalized with community-acquired pneumonia.

Cytokine 2018 07 20;107:1-8. Epub 2017 Nov 20.

Postgraduate Program in Health Sciences, Federal University of Bahia School of Medicine, Salvador, Brazil; Department of Pediatrics, Federal University of Bahia School of Medicine, Salvador, Brazil. Electronic address:

Community-acquired pneumonia (CAP) is the main cause of death in children under-5 years worldwide and Streptococcus pneumoniae is the most common bacterial agent. However, it is difficult to identify pneumococcal infection among children with CAP. We aimed to assess association between any cytokine/chemokine and pneumococcal infection in childhood CAP. Read More

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http://dx.doi.org/10.1016/j.cyto.2017.11.005DOI Listing
July 2018
12 Reads