11,216 results match your criteria Pneumonia Aspiration


Repeated Aspiration Pneumonia in a 7-Year-Old Girl With Undiagnosed Congenital Tracheoesophageal Fistula.

Arch Bronconeumol 2020 Jul 1. Epub 2020 Jul 1.

Unidad de Neumología y Fibrosis Quística, Servicio de Pediatría, Hospital Clínico Universitario de Valencia, Valencia, España.

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http://dx.doi.org/10.1016/j.arbres.2020.05.033DOI Listing

Effect of Oral Glucose Water Administration 1 Hour Preoperatively in Children with Cyanotic Congenital Heart Disease: A Randomized Controlled Trial.

Med Sci Monit 2020 Jul 4;26:e922642. Epub 2020 Jul 4.

Department of Nursing, Fujian Medical University, Fuzhou, Fujian, China (mainland).

BACKGROUND Guidelines recommend a clear liquid fasting time of 2 h before surgery, which is often exceeded, leading to adverse reactions (ARs) such as discomfort, thirst, and dehydration. We assessed the gastric contents and ARs after oral glucose water administration 1 h prior to surgery in children with cyanotic congenital heart disease (CCHD). MATERIAL AND METHODS This was a non-inferiority randomized controlled trial of children with CCHD enrolled at the Fujian Medical University Union Hospital from 09/2014 to 05/2017 and randomized to receive oral glucose water (10 g of glucose in 100 ml of warm water, 5 ml/kg) 2 h (2-h group, n=174) or 1 h (1-h group, n=170) before surgery. Read More

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http://dx.doi.org/10.12659/MSM.922642DOI Listing

Nasogastric versus Orogastric Bolus Tube Feeding in Preterm Infants: Pilot Randomized Clinical Trial.

Am J Perinatol 2020 Jul 3. Epub 2020 Jul 3.

Neonatal Intensive Care Unit, Mansoura University Children's Hospital, Mansoura, Egypt.

Objective:  According to the most recent metanalysis, the best way to establish safe enteral feeding in preterm babies using nasogastric or orogastric tubes is still not well understood. This study aimed to determine the effects of bolus nasal tubes versus bolus orogastric tubes on the time required to reach full enteral feeding in preterm infants, as well as to compare the incidence rates of adverse events including nonintentional removal or displacement of the feeding tube, aspiration pneumonia/pneumonitis, apnea, necrotizing enterocolitis, gastric residual, and growth parameters between the studied cohort of preterm infants.

Study Design:  We conducted an unblinded pilot randomized clinical trial on hemodynamically stable preterm infants (>28 weeks) recruited from level 2 neonatal intensive care unit at Mansoura University Children's Hospital from June 2015 to May 2017. Read More

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http://dx.doi.org/10.1055/s-0040-1713865DOI Listing

Impact of Oral Care and Antisepsis on the Prevalence of Ventilator-Associated Pneumonia.

Oral Health Prev Dent 2020 Apr 1;18(2):331-336. Epub 2020 Apr 1.

Purpose: This study aimed to evaluate the impact of oral care and use of chlorhexidine gluconate on the prevention of ventilator-associated pneumonia (VAP) in patients admitted to an intensive care unit (ICU).

Materials And Methods: An evaluation was performed on 229 patients admitted to ICU in 2012 (before implementation of oral care protocol) and 329 in 2013 (after the protocol). Oral care was based on the removal of secretions from the oral cavity with 0. Read More

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http://dx.doi.org/10.3290/j.ohpd.a44443DOI Listing

Brugada Pattern Type 2 Diagnosis Unmasked by Aspiration Pneumonia.

Cureus 2020 May 28;12(5):e8331. Epub 2020 May 28.

Cardiology, Detroit Medical Center, Detroit, USA.

Brugada syndrome (BrS) is a rare autosomal dominant mutation affecting sodium channels. Electrocardiography can show two Brugada patterns (BrP). Type 1 BrP usually causes sudden cardiac arrest (SCA). Read More

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http://dx.doi.org/10.7759/cureus.8331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325341PMC

PROPHETIC: Prospective Identification of Pneumonia in Hospitalized Patients in the Intensive Care Unit.

Chest 2020 Jun 29. Epub 2020 Jun 29.

Duke University, Durham, NC, USA; Duke Clinical Research Institute, Durham, NC, USA.

Background: Pneumonia is the leading infection-related cause of death. Using simple clinical criteria and contemporary epidemiology to identify patients at high risk of nosocomial pneumonia should enhance prevention efforts and facilitate development of new treatments in clinical trials.

Research Question: What are the clinical criteria and contemporary epidemiology trends helpful in identifying patients at high risk of nosocomial pneumonia?

Study Design And Methods: Within the intensive care units of 28 United States hospitals, we conducted a prospective cohort study among adults hospitalized more than 48 hours and considered high risk for pneumonia (defined as treatment with invasive or noninvasive ventilatory support or high levels of supplemental oxygen). Read More

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http://dx.doi.org/10.1016/j.chest.2020.06.034DOI Listing

Nutritional Status and Feeding Practice among Dysphagic Older Adult Inpatients in Vietnam.

J Nutr Sci Vitaminol (Tokyo) 2020 ;66(3):224-228

Jumonji University.

The Vietnamese older adult population has increased rapidly on an annual basis and dysphagia has become a common issue. The nutritional status of older adults in general and of dysphagic older adults in particular has not received adequate attention. The automatic solution for cases of serious choking/aspiration is still a prescription for tube feeding. Read More

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http://dx.doi.org/10.3177/jnsv.66.224DOI Listing
January 2020

Dysphagia in Parkinsonism: Prevalence, Predictors and Correlation with Severity of Illness Fasting).

J Assoc Physicians India 2020 May;68(5):22-25

Associate Professor, Department of Medicine, LTMMC and GH, Mumbai, Maharashtra.

Introduction: Dysphagia is frequently present in Parkinsonian syndromes and is associated with increased morbidity and mortality. Early identification of swallowing dysfunction is critical to minimize complications like aspiration pneumonia and malnutrition. Published prevalence rates for dysphagia in Parkinsonian syndromes vary widely with a very few studies from India. Read More

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[Acute respiratory distress in a frail older patient: spontaneous tooth aspiration].

Ned Tijdschr Tandheelkd 2020 May;127(5):282-285

A 68-year-old man presented at the emergency room with acute difficulty breathing. On account of recent subarachnoidal haemorrhage the patient was a resident of a care facility, and was also being treated for acute bronchitis there. Radiographic imaging of the lungs revealed a tooth with crown and pontic to have been inhaled. Read More

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http://dx.doi.org/10.5177/ntvt.2020.05.19132DOI Listing

Safety and Effectiveness of Early Oral Hydration in Patients After Cardiothoracic Surgery.

Am J Crit Care 2020 Jul;29(4):292-300

About the Authors: Catherine Ford and Donna McCormick are clinical nurses; Katrien Derycke-Chapman, Judith Marshall, Jessica Mancarella, and Anne Chepulis are former clinical nurses in the cardiothoracic intensive care unit, Heart and Vascular Center, Yale New Haven Hospital, New Haven, Connecticut.

Background: Patients fast after cardiothoracic surgery because of concerns for nausea, vomiting, dysphagia, and aspiration pneumonia; fasting, however, causes thirst, a distressing symptom. To our knowledge, no studies exist to guide hydration practices in this population.

Objective: To determine the effect of early oral hydration on adverse events and thirst in patients after cardiothoracic surgery. Read More

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http://dx.doi.org/10.4037/ajcc2020841DOI Listing

An unusual presentation of developmental anomalies of the cardiovascular system including tetralogy of fallot, double outlet right ventricle, patent foramen ovale and persistent right aortic arch in a Friesian calf.

BMC Vet Res 2020 Jun 30;16(1):224. Epub 2020 Jun 30.

Section of Herd Health and Animal Husbandry, School of Veterinary Medicine, Veterinary Sciences Centre, University College Dublin, Belfield, Dublin 4, Ireland.

Background: Congenital heart diseases are occasionally encountered in the bovine species. Ventricular septal defects (VSD) and atrial septal defects (ASD) are reported to be the most common; however, a vast collection have been reported [1, 2]. Congenital heart diseases is thought to represent less than 3% of all congenital abnormalities in calves [3]. Read More

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http://dx.doi.org/10.1186/s12917-020-02439-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325375PMC

Not Just for Kids: A Rare Case of Congenital Laryngeal Cleft in an Adult.

J Voice 2020 Jun 24. Epub 2020 Jun 24.

Department of Head and Neck Surgery, Kaiser Permanente Medical Center at Oakland, Oakland, California.

Objective: This case report aims to increase awareness of the diagnosis of laryngeal cleft in adult patients and discuss treatment options.

Methods: Case report and review of the literature.

Results: We present a case of a 56-year-old male referred for hoarseness and chronic cough that was discovered to have a type 2 laryngeal cleft. Read More

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http://dx.doi.org/10.1016/j.jvoice.2020.05.017DOI Listing

Coronavirus disease 2019 (COVID-19): challenges and management of aerosol-generating procedures in dentistry.

Evid Based Dent 2020 Jun;21(2):44-45

Oral Microbiologist, University of Health Sciences, Lahore, Pakistan.

Data sources Experimental investigation.Study design A retrospective review to evaluate the use of a negative-pressure otolaryngology viral isolation drape (NOVID) system to reduce cross-infection through aerosol. The apparatus consists of a plastic drape suspended over the surgical field in the head and neck region with a smoke evacuator suction placed inside the chamber with an ultra-low penetrating air (ULPA) efficiency rating and a fluid suction high-efficiency particulate air (HEPA) filter compartment. Read More

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http://dx.doi.org/10.1038/s41432-020-0088-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317264PMC

NRF2 pathway activation by KEAP1 inhibition attenuates the manifestation of aging phenotypes in salivary glands.

Redox Biol 2020 Jun 12;36:101603. Epub 2020 Jun 12.

Department of Gene Expression Regulation, Institute of Development, Aging and Cancer, Tohoku University, Japan. Electronic address:

Saliva plays an essential role in the maintenance of oral health. The oral cavity environment changes during aging mainly due to alterations in the secretion and composition of saliva. In particular, unstimulated basal salivary flow decreases with age. Read More

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http://dx.doi.org/10.1016/j.redox.2020.101603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322188PMC

Should nasogastric tube insertion during the COVID-19 pandemic be considered as an aerosol-generating procedure?

Br J Hosp Med (Lond) 2020 Jun 23;81(6):1-6. Epub 2020 Jun 23.

Department of General and Upper GI Surgery, Digestive Disease Centre, Royal Sussex County Hospital, Brighton, UK.

Nasogastric tubes are used frequently in surgical patients for bowel decompression, provision of enteral nutritional support and preventing aspiration of gastric contents. There is no conclusive research into the risk of COVID-19 transmission associated with nasogastric tube insertion, although evidence from the severe acute respiratory syndrome outbreak appears to suggest that there is no increased risk of transmission. However, close contact with a COVID-19 patient, especially those displaying respiratory symptoms, is likely to increase the risk of transmission. Read More

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http://dx.doi.org/10.12968/hmed.2020.0307DOI Listing
June 2020
0.366 Impact Factor

Diagnosis and treatments for oropharyngeal dysphagia: effects of capsaicin evaluated by newly developed ultrasonographic method.

J Smooth Muscle Res 2020 ;56(0):46-57

Department of General Internal Medicine 2, Kawasaki Medical School, Kurashiki, Japan.

Oropharyngeal dysphagia (OD) is a common symptom in the older people, and may cause fatal complications such as aspiration pneumonia. However, there is no established treatment for OD. The relationship between the transient receptor potential vanilloid 1 (TRPV1) and substance P released by activated TRPV1 was recently demonstrated. Read More

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http://dx.doi.org/10.1540/jsmr.56.46DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324726PMC
January 2020

A 95-year-old patient with unexpected coronavirus disease 2019 masked by aspiration pneumonia: a case report.

J Med Case Rep 2020 Jun 23;14(1):82. Epub 2020 Jun 23.

Internal Medicine and Geriatrics, "Hypertension Excellence Centre" of the European Society of Hypertension, Italian National Research Centre on Aging, Hospital "U. Sestilli", IRCCS INRCA, via della Montagnola n. 81, 60127, Ancona, Italy.

Background: Severe acute respiratory syndrome coronavirus-2 infection has become a pandemic disease (coronavirus disease 2019). The infection has moved from China to the rest of the world and Italy represents one of the most affected countries. Older adults are more susceptible to develop complications with the consequent highest mortality rates. Read More

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http://dx.doi.org/10.1186/s13256-020-02432-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309209PMC

Pulmonary complications in dogs with acute presentation of pancreatitis.

BMC Vet Res 2020 Jun 22;16(1):209. Epub 2020 Jun 22.

Department of Veterinary Sciences, Veterinary Teaching Hospital "Mario Modenato", University of Pisa, Via Livornese Lato monte, San Piero a Grado, 56122, Pisa, Italy.

Background: In humans, respiratory complications in patients with acute pancreatitis (AP) are a common life-threatening comorbidity. Since possible lung impairment has not been individually evaluated in canine AP, the aims of the present study were to: (1) describe the prevalence, types and severity of pulmonary complications in dogs with acute presentation of AP, and (2) evaluate their association with mortality. AP diagnosis was based on compatible clinical and laboratory parameters, abnormal canine pancreatic-lipase test, and positive abdominal ultrasound within 48 h from admission. Read More

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http://dx.doi.org/10.1186/s12917-020-02427-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310026PMC

Detection of SARS-CoV-2 by bronchoscopy after negative nasopharyngeal testing: Stay vigilant for COVID-19.

Respir Med Case Rep 2020 8;30:101120. Epub 2020 Jun 8.

Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, WA, USA.

Purpose: Real-time polymerase chain reaction (RT-PCR) detection of severe acute respiratory syndrome coronavirus (SARS-CoV-2) is required for diagnosis of coronavirus disease 2019 (COVID-19). Sensitivity of RT-PCR nasopharyngeal (NP) testing is presumed to be high, but there is no gold standard against which this has been determined. The objective was to determine whether lower respiratory tract infection (LRTI), detected in bronchoalveolar lavage fluid (BALF), occurs in the absence of upper respiratory tract infection with clinical testing of both specimen types. Read More

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http://dx.doi.org/10.1016/j.rmcr.2020.101120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298516PMC

Characterization of Dysphagia and Longitudinal Changes in Swallowing Function in Adults with Niemann-Pick Disease Type C Treated with Miglustat.

Dysphagia 2020 Jun 19. Epub 2020 Jun 19.

Centre for Neuroscience of Speech, The University of Melbourne, 550 Swanston Street, Parkville, Melbourne, VIC, 3010, Australia.

Niemann-Pick disease type C (NPC) is a rare, autosomal recessive neurodegenerative disease, characterized by progressive psychiatric and neurological deficits. Neurological symptoms include cognitive decline and dysphagia. Aspiration pneumonia secondary to dysphagia is a leading cause of death in NPC. Read More

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http://dx.doi.org/10.1007/s00455-020-10145-8DOI Listing

Outcomes of endotracheal suctioning in non-vigorous neonates born through meconium-stained amniotic fluid: a systematic review and meta-analysis.

Arch Dis Child Fetal Neonatal Ed 2020 Jun 19. Epub 2020 Jun 19.

Faculty of Medicine and Public Health, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, Thailand.

Objective: We aimed to systematically review and analyse the outcomes of non-endotracheal suctioning (non-ETS) versus ETS in non-vigorous meconium-stained neonates.

Design: We conducted a systematic review of non-ETS and ETS in non-vigorous infants born through meconium-stained amniotic fluid (MSAF). We searched PubMed/Medline, Scopus, Clinical Trials. Read More

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http://dx.doi.org/10.1136/archdischild-2020-318941DOI Listing
June 2020
3.120 Impact Factor

The cost-effectiveness of food consistency modification with xanthan gum-based Nutilis Clear® in patients with post-stroke dysphagia in Poland.

BMC Health Serv Res 2020 Jun 17;20(1):552. Epub 2020 Jun 17.

HealthQuest, Warsaw, Poland.

Background: Dysphagia is a well-known stroke complication characterised by difficulty in swallowing. It may affect the majority of stroke patients and increases mortality and morbidity, due to aspiration pneumonia and malnutrition. Food thickening may help patients to feed themselves, and its effectiveness was demonstrated. Read More

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http://dx.doi.org/10.1186/s12913-020-05411-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302358PMC

Humidifier Use and Prone Positioning in a Patient with Severe COVID-19 Pneumonia and Endotracheal Tube Impaction Due to Highly Viscous Sputum.

Cureus 2020 Jun 15;12(6):e8626. Epub 2020 Jun 15.

Department of Internal Medicine, Hyogo Prefectural Tamba Medical Center, Tanba, JPN.

COVID-19 can lead to severe pneumonia, requiring mechanical ventilation. While increased sputum secretion could cause airway obstruction during mechanical ventilation, there are few reported cases in the literature. We report a case of a 65-year-old man with diabetes and severe COVID-19 pneumonia requiring mechanical ventilation and treated with hydroxychloroquine, azithromycin, nafamostat, and prone positioning. Read More

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http://dx.doi.org/10.7759/cureus.8626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296879PMC

Oropharyngeal Dysphagia and Aspiration Pneumonia Following Coronavirus Disease 2019: A Case Report.

Dysphagia 2020 Jun 12. Epub 2020 Jun 12.

Department of Rehabilitation Medicine I, School of Medicine, Fujita Health University, 1-98 Dengakugakubo, Kutsukake, Toyoake, Aichi, 470-1192, Japan.

Cranial nerve involvement is a finding often observed in patients infected with severe acute respiratory syndrome coronavirus 2 during the pandemic outbreak of coronavirus disease 2019 (COVID-19). To our knowledge, this is the first report of oropharyngeal dysphagia associated with COVID-19. A 70-year-old male developed dysphagia and consequent aspiration pneumonia during recovery from severe COVID-19. Read More

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http://dx.doi.org/10.1007/s00455-020-10140-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290133PMC

Comparing the Safety and Cost of Image-Guided Percutaneous Gastrostomy Tube Placement in the Outpatient Versus Overnight Observation Setting in a Single-Center Retrospective Study.

Acad Radiol 2020 Jun 8. Epub 2020 Jun 8.

Emory University Department of Radiology, Emory University Hospital, 1364 Clifton Road NE, Suite D112, Atlanta, GA 30322.

Rationale And Objectives: Historically, patients undergoing image-guided percutaneous gastrostomy tube placement have been admitted overnight with feeds commencing 12-24 hours postprocedure. With new expedited feeding protocols starting 3-4 hours postprocedure, same-day discharge is now possible. The purpose of this study was to evaluate the safety and cost of image-guided percutaneous gastrostomy tube placement as an outpatient procedure. Read More

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http://dx.doi.org/10.1016/j.acra.2020.04.044DOI Listing

Ascending Paralysis in a 36-Year-Old Woman With Bipolar Disorder and Recent Aspiration Pneumonia.

J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620931649

Louisiana State University Health Sciences Center, New Orleans, LA, USA.

Guillain-Barré syndrome (GBS) is an acute inflammatory demyelinating polyneuropathy affecting both motor and sensory peripheral nerves. Typically presenting after a gastrointestinal or a respiratory tract infection, it manifests as ascending paralysis with concomitant areflexia in patients. Cytoalbuminologic dissociation is a supportive finding on cerebrospinal fluid (CSF) analysis. Read More

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http://dx.doi.org/10.1177/2324709620931649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290259PMC

T4 cervical esophageal cancer cured with modern chemoradiotherapy: A case report.

World J Clin Cases 2020 May;8(10):1950-1957

Department of Radiation Oncology, National University Cancer Institute, National University Hospital, Tan Tock Seng Hospital, Singapore 119228, Singapore.

Background: T4 esophageal cancer portends a poor prognosis, particularly when it is complicated by a tracheoesophageal fistula (TEF) either resulting from disease or occurring as a complication of treatment. Patients with TEF that occurs during treatment are commonly treated with palliative intent because fistula-associated treatment complications such as aspiration pneumonia and mediastinitis are associated with high morbidity and mortality. To date, there is no clear evidence on the optimal treatment of T4 esophageal cancer, particularly when a TEF formation occurs. Read More

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http://dx.doi.org/10.12998/wjcc.v8.i10.1950DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262722PMC

Interventions for oropharyngeal dysphagia in acute and critical care: a systematic review and meta-analysis.

Intensive Care Med 2020 Jul 8;46(7):1326-1338. Epub 2020 Jun 8.

Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK.

Purpose: To determine the effectiveness of dysphagia interventions compared to standard care in improving oral intake and reducing aspiration for adults in acute and critical care.

Methods: We searched electronic literature for randomised and quasi-randomised trials and bibliography lists of included studies to March 2020. Study screening, data extraction, risk of bias and quality assessments were conducted independently by two reviewers. Read More

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http://dx.doi.org/10.1007/s00134-020-06126-yDOI Listing
July 2020
7.214 Impact Factor

Improvement of a delayed swallowing reflex following treatment for advanced head and neck cancer.

Cancers Head Neck 2020 2;5. Epub 2020 Jun 2.

Department of Otorhinolaryngology, Head and Neck Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-cho, Aoba-ku, Sendai, 980-8575 Japan.

Background: The latency of the swallowing reflex is an important factor causing dysphagia in head and neck cancer patients. Although there are many reports comparing voluntary swallowing function before and after treatment, few studies have focused on the latency of the swallowing reflex, which is a risk factor for pneumonia due to silent aspiration. The aim of this retrospective study was to clarify the changes in the latency of the swallowing reflex before and after treatment. Read More

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http://dx.doi.org/10.1186/s41199-020-00055-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265250PMC

Myopathies featuring early or prominent dysphagia.

Muscle Nerve 2020 Jun 8. Epub 2020 Jun 8.

Division of Neuromuscular Medicine, Department of Neurology, Mayo Clinic, Rochester, Minnesota.

Background: Limited data exist regarding myopathies with early or prominent dysphagia.

Methods: A retrospective study was performed (January 2003 to August 2019) to identify myopathy patients in whom dysphagia was the initial symptom or was disproportionately severe compared with limb weakness.

Results: Thirty-two patients were identified. Read More

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http://dx.doi.org/10.1002/mus.26996DOI Listing

Texture-Modified Diet for Improving the Management of Oropharyngeal Dysphagia in Nursing Home Residents: An Expert Review.

J Nutr Health Aging 2020 ;24(6):576-581

María Ballesteros-Pomar, Department of Endocrinology and Nutrition, Complejo Asistencial Universitario de León, León, Spain,

Objectives: This paper provides evidence-based and, when appropriate, expert reviewed recommendations for long-stay residents who are prescribed texture-modified diets (TMDs), with the consideration that these residents are at high risk of worsening oropharyngeal dysphagia (OD), malnutrition, dehydration, aspiration pneumonia, and OD-associated mortality, poorer quality of life and high costs.

Design: Nestlé Health Science funded an initial virtual meeting attended by all authors, in which the unmet needs and subsequent recommendations for OD management were discussed. The opinions, results, and recommendations detailed in this paper are those of the authors, and are independent of funding sources. Read More

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http://dx.doi.org/10.1007/s12603-020-1377-5DOI Listing
January 2020

Effects of Diluents, Saliva and Other Organics on the Microbicidal Activity of Cetylpyridinium Chloride and Povidone-iodine.

Biocontrol Sci 2020 ;25(2):45-53

Sunstar Shizuoka Innovation Center, Sunstar Inc.

Povidone-iodine (PVP-I) is used for infection control and preoperative sterilization of the oral and pharyngeal regions. Marketed preparations containing cetylpyridinium chloride (CPC) are used to inhibit growth of oral bacteria. We conducted an in vitro study of the sterilizing effects of these microbicides on 10 oral bacterial strains and fungi related to pneumonia and periodontal disease, after dilution with phosphate-buffered saline (PBS), saliva, and components in saliva. Read More

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http://dx.doi.org/10.4265/bio.25.45DOI Listing
January 2020

Cardiothoracic Patients with Unilateral Vocal Fold Paralysis: Pneumonia Rates Following Injection Laryngoplasty.

Ann Otol Rhinol Laryngol 2020 Jun 8:3489420933650. Epub 2020 Jun 8.

Department of Otorhinolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, MN, USA.

Objective: Recurrent laryngeal nerve injury is a potential complication of cardiothoracic surgery and cause of unilateral vocal fold paralysis (UVFP). Injection laryngoplasty (IL) is an intervention offered to patients with UVFP to alleviate symptoms including dysphagia, dysphonia and weak cough. There is no definitive evidence that IL prevents pneumonia. Read More

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http://dx.doi.org/10.1177/0003489420933650DOI Listing

Long-term intubation and high rate of tracheostomy in COVID-19 patients might determine an unprecedented increase of airway stenoses: a call to action from the European Laryngological Society.

Eur Arch Otorhinolaryngol 2020 Jun 6. Epub 2020 Jun 6.

Department of Otorhinolaryngology, Head and Neck Surgery, IRCCS Ospedale Policlinico San Martino, Largo R. Benzi 10, 16132, Genoa, Italy.

Introduction: The novel Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2, may need intensive care unit (ICU) admission in up to 12% of all positive cases for massive interstitial pneumonia, with possible long-term endotracheal intubation for mechanical ventilation and subsequent tracheostomy. The most common airway-related complications of such ICU maneuvers are laryngotracheal granulomas, webs, stenosis, malacia and, less commonly, tracheal necrosis with tracheo-esophageal or tracheo-arterial fistulae.

Materials And Methods: This paper gathers the opinions of experts of the Laryngotracheal Stenosis Committee of the European Laryngological Society, with the aim of alerting the medical community about the possible rise in number of COVID-19-related laryngotracheal stenosis (LTS), and the aspiration of paving the way to a more rationale concentration of these cases within referral specialist airway centers. Read More

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http://dx.doi.org/10.1007/s00405-020-06112-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275663PMC

Management of Pneumonia Syndromes in the Hospital: Make Pneumonia Your Best Friend.

Med Clin North Am 2020 Jul 7;104(4):587-599. Epub 2020 May 7.

Division of Hospital Medicine, Department of Medicine, University of California San Francisco (UCSF), Box 0131, San Francisco, CA 94143, USA. Electronic address: https://twitter.com/AbelsonJesse.

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http://dx.doi.org/10.1016/j.mcna.2020.02.006DOI Listing

Use of an Ultra-slim Gastroscope to Accomplish Endoscopist-Facilitated Rescue Intubation During ERCP: A Novel Approach to Enhance Patient and Staff Safety.

Dig Dis Sci 2020 Jun 5. Epub 2020 Jun 5.

Division of Gastroenterology and Hepatology, Stanford University School of Medicine, 300 Pasteur Drive, MC 5244, Stanford, CA, 94305, USA.

Background: ERCP is often performed under monitored anesthesia care (MAC) rather than general anesthesia (GA), with patients positioned semi-prone on the fluoroscopy table. Rarely, a MAC ERCP must be converted to GA due to hypoxia or retained food in the stomach. In these circumstances, standard intubation is associated with a significant delay and potential for patient/staff injury during repositioning. Read More

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http://dx.doi.org/10.1007/s10620-020-06360-wDOI Listing

Point-of-care lung ultrasound in three neonates with COVID-19.

Eur J Pediatr 2020 Jun 5. Epub 2020 Jun 5.

Pediatrics Department, Virgen de la Salud Hospital, Toledo, Spain.

Since March 2020, the world is involved in the COVID-19 pandemic, a disease caused by a novel virus called SARS-CoV-2. Some authors have described the ultrasonographic findings of COVID-19 pneumonia in adults and children, but data on neonates are lacking. Our objective was to describe the ultrasonographic lung pattern on newborns with SARS-CoV-2 infection during the COVID-19 pandemic. Read More

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http://dx.doi.org/10.1007/s00431-020-03706-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274567PMC

Comparison of ceftriaxone plus macrolide and ampicillin/sulbactam plus macrolide in treatment for patients with community-acquired pneumonia without risk factors for aspiration: an open-label, quasi-randomized, controlled trial.

BMC Pulm Med 2020 Jun 5;20(1):160. Epub 2020 Jun 5.

Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, 54 Shogoin-kawaracho, Sakyo, Kyoto, 606-8507, Japan.

Background: Ceftriaxone (CTRX) and ampicillin/sulbactam (ABPC/SBT) are recommended by various guidelines as the first-line antibiotics for community-acquired pneumonia (CAP). However, which of these antibiotics is more effective for treating non-aspiration CAP remains unclear.

Methods: This study was a prospective, single-center, open-label, quasi-randomized controlled trial. Read More

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http://dx.doi.org/10.1186/s12890-020-01198-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275365PMC

Cryptococcal osteomyelitis of the Zygomatic bone: a case report.

BMC Infect Dis 2020 Jun 5;20(1):399. Epub 2020 Jun 5.

Department of Otorhinolaryngology, Head and Neck Surgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.

Background: Disseminated cryptococcosis is a well-characterized complication in immunocompromised patients with cryptococcal pneumonia or meningitis; however, isolated cryptococcal osteomyelitis is a rare entity that occurs in approximately 5% of patients with cryptococcosis. Cryptococcal osteomyelitis in the head and neck region is extremely rare. To the best of our knowledge, no cases of cryptococcal osteomyelitis affecting only the zygomatic bone have been reported to date. Read More

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http://dx.doi.org/10.1186/s12879-020-05123-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275450PMC

Indications for non-invasive ventilation in respiratory failure.

Rev Recent Clin Trials 2020 Jun 3. Epub 2020 Jun 3.

Department of Anesthesiology and Intensive Care, Fondazione Policlinico Universitario "A Gemelli" IRCCS - Università Cattolica del Sacro Cuore, Rome. Italy.

Background: Non-invasive ventilation (NIV) is increasingly being used to treat episodes of acute respiratory failure not only in critical care and respiratory wards, but also in emergency departments. The aim of this review is to summarize the current indications for the management of NIV for respiratory failure.

Methods: Current literature about the topic was reviewed and critically reported to describe the rationale and physiologic advantages of NIV in various situations of respiratory failure. Read More

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http://dx.doi.org/10.2174/1574887115666200603151838DOI Listing

Mechanism of dysphagia after acute traumatic cervical spinal cord injury.

J Neurotrauma 2020 Jun 3. Epub 2020 Jun 3.

Spinal Injuries Center, 73491, Department of Orthopedic Surgery, Iizuka, Fukuoka, Japan;

Introduction: Swallowing dysfunction, which may cause aspiration pneumonia, is one of the most important complications of treatment of traumatic cervical spinal cord injury (CSCI); however, the mechanism of dysphagia is not well understood. No previous studies have reported the association between morphological changes of the soft tissue and dysphagia. We aimed to determine the factors associated with severity of dysphagia following CSCI and elucidate its mechanism. Read More

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http://dx.doi.org/10.1089/neu.2020.6983DOI Listing

Impact of Key Nicotinic AChR Subunits on Post-Stroke Pneumococcal Pneumonia.

Vaccines (Basel) 2020 May 28;8(2). Epub 2020 May 28.

Institute for Medical Immunology, Charité-Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, 13353 Berlin, Germany.

Pneumonia is the most frequent severe medical complication after stroke. An overactivation of the cholinergic signaling after stroke contributes to immunosuppression and the development of spontaneous pneumonia caused by Gram-negative pathogens. The α7 nicotinic acetylcholine receptor (α7nAChR) has already been identified as an important mediator of the anti-inflammatory pathway after stroke. Read More

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http://dx.doi.org/10.3390/vaccines8020253DOI Listing

Tracheobronchial foreign body aspiration in children: A retrospective single-center cross-sectional study.

Medicine (Baltimore) 2020 May;99(22):e20480

Department of Respiratory Medicine, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, China.

Foreign body (FB) aspiration is a common and serious problem in childhood as it requires early recognition and treatment to avoid potentially lethal consequences. This study aimed to characterize the clinical and epidemiological features of airway FBs in a pediatric Chinese population.A retrospective review of medical records of children aged 0 to 14 years who attended with a diagnosis of FB aspiration the Shanghai Children's Hospital between January 2013 and December 2017 was carried out. Read More

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http://dx.doi.org/10.1097/MD.0000000000020480DOI Listing

Exploratory study of clinical effectiveness and safety of TJ-116 bukuryoingohangekobokuto for anxiety and postoperative water brash in esophageal cancer patients (TJ116E).

Medicine (Baltimore) 2020 May;99(22):e20317

Department of Kampo Medicine.

Background: Patients with esophageal cancer suffer from anxiety in the perioperative period surrounding esophagectomy; this may increase the risk of postoperative complications. In particular, postoperative aspiration pneumonia carries a high risk of hospital mortality. Bukuryoingohangekobokuto (BRIHK) is a traditional Japanese medicine formula used to treat anxiety, the feeling of a foreign body in the esophagus, and water brash. Read More

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http://dx.doi.org/10.1097/MD.0000000000020317DOI Listing

The prevalence and findings of fibre-optic endoscopic evaluation of swallowing in hospitalised patients with dysphagia.

J Oral Rehabil 2020 Jun 1. Epub 2020 Jun 1.

Department of Rehabilitation Medicine I, School of Medicine, Fujita Health University, Toyoake, Japan.

Swallowing disorder or dysphagia is quite common in hospitalised patients. Using fibre-optic endoscopic evaluation of swallowing (FEES) is one of the clinical standards for evaluating swallowing disorder to prevent serious consequences such as aspiration pneumonia. This study aimed to determine the prevalence and the associated risk of dysphagia in hospitalised patients by using FEES finding. Read More

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http://dx.doi.org/10.1111/joor.13026DOI Listing

Risk factors associated with the development of aspiration pneumonia in patients receiving radiotherapy for head and neck cancer: retrospective study.

Head Neck 2020 Jun 1. Epub 2020 Jun 1.

Department of Clinical Oral Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

Background: Patients with head and neck cancer who are receiving radiotherapy can develop aspiration pneumonia. Determination of the incidence of aspiration pneumonia and the associated risk factors could facilitate the identification of high-risk patients.

Methods: In this retrospective study, we determined the incidence of aspiration pneumonia in 357 patients receiving radiotherapy along with oral care for head and neck cancer. Read More

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http://dx.doi.org/10.1002/hed.26314DOI Listing

Bilateral Vocal Cord Immobility After Chemoradiotherapy For Nasopharyngeal Carcinoma.

Gulf J Oncolog 2020 May;1(33):80-83

Department of Otorhinolaryngology-Head and Neck Surgery, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, Malaysia.

Post chemoradiation vocal cord immobility is a rare complication and this maybe life threatening when patients present with severe aspiration and recurrent pneumonia or even worse if they have an upper airway obstruction. We report a case of nasopharyngeal carcinoma patient whom after receiving curative concurrent chemoradiotherapy, presented with episodes of shortness of breath and aspiration pneumonia finally diagnosed with bilateral vocal cord immobility. She had no evidence of tumour recurrence. Read More

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[Progress Report on Cases of Peripherally Inserted Central Catheter (PICC) Management in Our Hospital, Including Elderly Patients].

Nihon Ronen Igakkai Zasshi 2020 ;57(2):173-181

Sanno Hospital.

Aim: In our hospital, the number of cases in which peripherally inserted central catheters (PICCs) are used has increased; these patients include elderly people who cannot take medications orally, patients with low levels of awareness, and patients with dysphagia. We report the situation at this time mainly with regard to the number of days on which PICCs were used.

Methods: Fifteen elderly patients (male, n=7; female, n=8; average age, 89. Read More

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http://dx.doi.org/10.3143/geriatrics.57.173DOI Listing
January 2020

A case of simultaneous superficial hypopharyngeal and superficial esophageal cancers treated by endoscopic resection.

J Nippon Med Sch 2020 May 30. Epub 2020 May 30.

Tokyo Women's Medical University Medical Center East, Department of Surgery.

In recent times, the diagnosis and treatment of superficial laryngopharyngeal cancers has been receiving a lot of attention. Here, we present a case of superficial hypopharyngeal cancer and superficial esophageal cancer for which endoscopic laryngo-pharyngeal surgery (ELPS) and endoscopic submucosal dissection (ESD) were performed simultaneously. The patient was a 67-year-old male. Read More

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http://dx.doi.org/10.1272/jnms.JNMS.2020_87-509DOI Listing

Postintubation Dysphagia During COVID-19 Outbreak-Contemporary Review.

Dysphagia 2020 May 28. Epub 2020 May 28.

Department of Otorhinolaryngology and Phoniatrics-Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

The COVID-19 is a global pandemic. Its rapid dissemination and serious course require a novel approach to healthcare practices. Severe disease progression is often associated with the development of the Acute Respiratory Distress Syndrome and may require some form of respiratory support, including endotracheal intubation, mechanical ventilation, and enteral nutrition through a nasogastric tube. Read More

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http://dx.doi.org/10.1007/s00455-020-10139-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255443PMC