13,124 results match your criteria Pneumocystis carinii jiroveci Pneumonia


Is sex necessary for the proliferation and transmission of Pneumocystis?

PLoS Pathog 2018 Dec 6;14(12):e1007409. Epub 2018 Dec 6.

Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America.

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December 2018

[Opportunistic infections: What's new?]

Dtsch Med Wochenschr 2018 Dec 3;143(24):1755-1758. Epub 2018 Dec 3.

Klinische Arbeitsgemeinschaft AIDS Deutschland (KAAD), Sektion der Deutschen AIDS-Gesellschaft (DAIG).

Guidelines from 3 clinical societies and peer-reviewed publications have been reviewed for recent changes in the management of opportunistic infections. Trimethoprim and sulfamethoxazol administered intravenously is an option to treat cerebral toxoplasmosis if oral therapy is not feasible. CD4 T cell cut-off for starting prophylaxis with trimethoprim and sulfamethoxazole is now 200/µl. Read More

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December 2018

Cytomegaloviral or Pneumonia Increases Mortality in Systemic Lupus Erythematosus Patients with Pulmonary Hemorrhage: Evidence from Bronchoalveolar Lavage Fluid.

J Rheumatol 2018 Dec 1. Epub 2018 Dec 1.

From the Division of Allergy, Immunology, and Rheumatology, Department of Medicine, Taipei Veterans General Hospital, Taipei City; Faculty of Medicine, National Yang-Ming University, Taiwan and Institute of Clinical Medicine, National Yang-Ming University, Taipei City, Taiwan. The study was funded partially by grants from Taipei Veterans General Hospital (V107A-005 and V107B-018). The funder has no role in study design, data collection, analysis, and interpretation of data, writing the manuscript, and the decision to submit this work for publication. Y.S. Sun, MD, Division of Allergy, Immunology, and Rheumatology, Department of Medicine, Taipei Veterans General Hospital, and Faculty of Medicine, National Yang-Ming University; D.F. Huang, MD, Division of Allergy, Immunology, and Rheumatology, Department of Medicine, Taipei Veterans General Hospital, and Faculty of Medicine, National Yang-Ming University; F.C. Lin, MD, PhD, Department of Chest Medicine, Taipei Veterans General Hospital, and Faculty of Medicine, National Yang-Ming University; C.K. Hsu, MD, Department of Chest Medicine, Taipei Veterans General Hospital Yuli Branch; I.T. Sun, MD, Department of Ophthalmology, E-Da Hospital, I-Shou University; S.C. Chang, MD, PhD, Professor, Department of Chest Medicine, Taipei Veterans General Hospital, and Institute of Emergency and Critical Care Medicine, National Yang-Ming University; C.Y. Tsai, MD, PhD, Professor, Division of Allergy, Immunology, and Rheumatology, Department of Medicine, Taipei Veterans General Hospital, and Faculty of Medicine, National Yang-Ming University; C.C. Lai, MD, Division of Allergy, Immunology, and Rheumatology, Department of Medicine, Taipei Veterans General Hospital, and Faculty of Medicine, and Institute of Clinical Medicine, National Yang-Ming University. Address correspondence to Dr. C.C. Lai, Division of Allergy, Immunology, and Rheumatology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Beitou District, Taipei City, Taiwan 11217 (R.O.C.). E-mail: Accepted for publication August 10, 2018.

Objective: To evaluate the role of cytomegaloviral or pneumonia (CMV/PJP) in systemic lupus erythematosus (SLE) patients with pulmonary hemorrhage (PH).

Methods: We retrospectively examined hospital records for 27 SLE patients with PH who received bronchoalveolar lavage fluid (BALF) analyses. Clinical profile and mortality rates were compared between groups with and without CMV/PJP. Read More

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December 2018

The clinical impact of pneumocystis and viral PCR testing on bronchoalveolar lavage in immunosuppressed patients.

Respir Med 2018 Dec 22;145:35-40. Epub 2018 Oct 22.

Division of Pulmonary and Critical Care Medicine, University of Rochester Medical Center/Strong Memorial Hospital, Rochester, NY, USA.

Introduction: Pulmonary infiltrates in immunosuppressed patients are common. Yields from bronchoscopy with bronchoalveolar lavage (BAL) has been reported to be between 31 and 65%. The clinical impact of pneumocystis and viral Polymerase chain reaction (PCR) testing on BAL has not been extensively evaluated in a mixed immunosuppressed patient population. Read More

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December 2018
3 Reads

Predictive factors of pneumocystis pneumonia in patients with rheumatic diseases exposed to prolonged high-dose glucocorticoids.

Ann Rheum Dis 2018 Nov 28. Epub 2018 Nov 28.

Department of Medicine, Beaujon University Hospital, Clichy, France.

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November 2018

Coinfection of pneumocystis jiroveci pneumonia and pulmonary aspergillosis in a non-HIV-infected patient.

J Microbiol Immunol Infect 2018 Dec 12;51(6):860-861. Epub 2018 Nov 12.

Department of Critical Care Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; College of Human Science and Social Innovation, Hungkuang University, Taichung, 43302, Taiwan; School of Chinese Medicine, China Medical University, Taichung, 40447, Taiwan. Electronic address:

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December 2018
1 Read

Therapy and Management of Infection.

J Fungi (Basel) 2018 Nov 22;4(4). Epub 2018 Nov 22.

Public Health Wales Microbiology Cardiff, UHW, Heath Park, Cardiff CF14 4XW, UK.

The rates of pneumonia (PcP) are increasing in the HIV-negative susceptible population. Guidance for the prophylaxis and treatment of PcP in HIV, haematology, and solid-organ transplant (SOT) recipients is available, although for many other populations (e.g. Read More

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November 2018
4 Reads

[Epidemiology of invasive mycoses: A landscape in continuous change].

Rev Iberoam Micol 2018 Nov 19. Epub 2018 Nov 19.

Departamento de Inmunología, Microbiología y Parasitología, Facultad de Medicina y Enfermería, Universidad del País Vasco/Euskal Herriko Unibertsitatea (UPV/EHU), Bilbao, España. Electronic address:

The landscape of invasive mycoses is in a continuous evolution with important implications for their diagnosis and treatment. The overall burden remains high, particularly in neonates and the elderly, patients admitted to intensive care units, using prostheses, catheters or other intravenous devices, those receiving different immunosuppressant treatments or antineoplastic chemotherapy, or transplant recipients. In addition, opportunistic mycoses can be associated with HIV infection. Read More

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November 2018
2 Reads

Pneumocystis jiroveci pneumonia in kidney and simultaneous pancreas kidney transplant recipients in the present era of routine post-transplant prophylaxis: risk factors and outcomes.

BMC Nephrol 2018 Nov 21;19(1):332. Epub 2018 Nov 21.

Division of Nephrology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, 1685 Highland Ave, 4177 Medical Foundation Centennial Building, Madison, WI, 53705, USA.

Background: The goal of this study was to identify predictors for development of Pneumocystis jirovecii pneumonia (PJP) in kidney and simultaneous kidney and pancreas transplant recipients in the present era of universal primary prophylaxis.

Methods: We reviewed adult recipients of kidney transplant or simultaneous pancreas and kidney transplant at the University of Wisconsin between January 1, 1994 and December 31, 2016. Patients diagnosed with PJP during this time frame were included. Read More

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November 2018
3 Reads

Clinical course, treatment and outcome of Pneumocystis pneumonia in immunocompromised adults: a retrospective analysis over 17 years.

Crit Care 2018 Nov 19;22(1):307. Epub 2018 Nov 19.

Department of Nephrology and Hypertension, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625, Hannover, Germany.

Background: Despite modern intensive care with standardized strategies against acute respiratory distress syndrome (ARDS), Pneumocystis pneumonia (PcP) remains a life-threatening disease with a high mortality rate. Here, we analyzed a large mixed cohort of immunocompromised patients with PcP, with regard to clinical course and treatment, and aimed at identifying predictors of outcome.

Methods: This was a single-center retrospective analysis in a tertiary care institution across 17 years. Read More

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November 2018
3 Reads

Paediatric deaths in a tertiary government hospital setting, Malawi.

Paediatr Int Child Health 2018 Nov 19:1-9. Epub 2018 Nov 19.

g Centre for Medical Education , Queen's University , Belfast , UK.

Background: Malawisuccessfully achieved Millennium Development Goal (MDG) four by decreasing the under-5 mortality rate by two-thirds in 2012. Despite this progress child mortality is still high and in 2013, the leading causes of death in under-5s were malaria, acute respiratory infections and HIV/AIDS.

Aims: To determine the causes of inpatient child death including microbiological aetiologies in Malawi. Read More

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November 2018
5 Reads

The Phenotype and Treatment of WIP Deficiency: Literature Synopsis and Review of a Patient With Pre-transplant Serial Donor Lymphocyte Infusions to Eliminate CMV.

Front Immunol 2018 2;9:2554. Epub 2018 Nov 2.

Division of Pediatric Hematology-Oncology, Department of Pediatrics and Adolescent Medicine, Medical University Graz, Graz, Austria.

Early diagnosis of primary immunodeficiency disorders (PID) is vital and allows directed treatment, especially in syndromes with severe or profound combined immunodeficiency. In PID patients with perinatal CMV or other opportunistic, invasive infections (e.g. Read More

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November 2018
8 Reads

Pneumocystis jirovecii pneumonia (PJP) prophylaxis patterns among patients with rheumatic diseases receiving high-risk immunosuppressant drugs.

Semin Arthritis Rheum 2018 Nov 3. Epub 2018 Nov 3.

Division of Rheumatology, University of California San Francisco, United States.

Introduction/objectives: Pneumocystis jirovecii pneumonia (PJP) is a rare but potentially fatal opportunistic infection; however, consensus varies around which conditions or medications confer a level of risk sufficient to justify antibiotic prophylaxis for PJP. We used electronic health record (EHR) data to assess the current patterns of PJP prophylaxis, PJP outcomes, and prophylaxis-related adverse events among patients with rheumatic diseases who were receiving high-risk immunosuppressant drugs.

Methods: Data derive from the EHR of a large health system. Read More

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November 2018
3 Reads

Pneumocystis jirovecii pneumonia infection in pemphigus patients treated with rituximab: an observational nationwide epidemiological study in Taiwan.

Eur J Dermatol 2018 Nov 13. Epub 2018 Nov 13.

Center for Big Data Analytics and Statistics, Chang Gung Memorial Hospital, Linkou, China, Department of Medical Research, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Taiwan.

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November 2018
1 Read

Comparative Evaluation Between the RealStar PCR Kit and the AmpliSens ()-FRT PCR Kit for Detecting in Non-HIV Immunocompromised Patients.

Ann Lab Med 2019 Mar;39(2):176-182

Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background: Real-time PCR is more sensitive than microscopic examination for detecting . We compared the performance of two assays for detecting DNA: the RealStar PCR Kit 1.0 CE (Altona Diagnostics, Hamburg, Germany) and the AmpliSens ()-FRT PCR kit (InterLabService Ltd. Read More

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March 2019
3 Reads

Holobiont suture zones: Parasite evidence across the European house mouse hybrid zone.

Mol Ecol 2018 Nov 14. Epub 2018 Nov 14.

The Czech Academy of Sciences, Institute of Vertebrate Biology, Květná 8, 603 65, Brno, Czech Republic.

Parasite hybrid zones resulting from host secondary contact have never been described in nature although parasite hybridization is well known and secondary contact should affect them similarly to free-living organisms. When host populations are isolated, diverge, and re-contact, intimate parasites (host specific, direct life cycle) carried during isolation will also meet and so may form parasite hybrid zones. If so, we hypothesize these should be narrower than the host's hybrid zone as shorter parasite generation time allows potentially higher divergence. Read More

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November 2018
1 Read

Collaborative Physician-Pharmacist-Managed Multiple Myeloma Clinic Improves Guideline Adherence and Prevents Treatment Delays.

J Oncol Pract 2018 Nov;14(11):e674-e682

University of Illinois at Chicago, Chicago, IL.

Purpose:: We hypothesized that a multidisciplinary collaborative physician-pharmacist multiple myeloma clinic would improve adherence to treatment and supportive care guidelines as well as reduce delays in receiving oral antimyeloma therapy.

Methods:: From March 2014 to February 2015, an oncology pharmacist provided consultation for all patients in a specialist myeloma clinic. This included reviewing medications, ensuring physician adherence to supportive care guidelines, managing treatment-related adverse effects, and navigating issues involving access to oral specialty medications (collaborative clinic). Read More

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November 2018
4 Reads

Reactivation of dormant/latent fungal infection.

J Infect 2018 Jul 6. Epub 2018 Jul 6.

INSERM U1070, Université de Poitiers, Poitiers, France; Faculté de médecine et pharmacie, Université de Poitiers, Poitiers, France; Service de maladies infectieuses et tropicales, CHU de Poitiers, Poitiers, France.

Objectives: Latent infections are well-known for bacteria such as Mycobacterium tuberculosis and for viruses such as Herpesviridae and parasites like Leishmania spp. or Toxoplasma gondii. However, invasive fungi may also be latent and come to reactivate. Read More

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Pneumocystis jirovecii pneumonia prophylaxis in allogeneic hematopoietic cell transplant recipients: can we always follow the guidelines?

Bone Marrow Transplant 2018 Nov 9. Epub 2018 Nov 9.

Department of Hematology and Cellular Therapy, Assistance Publique-Hôpitaux de Paris; Henri Mondor Hospital, 94000, Créteil, France.

Pneumocystis jirovecii pneumonia (PCP) is a life-threatening disease in allogeneic hematopoietic cell transplantation (HCT) recipients. Trimethoprim-sulfamethoxazole (TMP-SMX) is the preferred prophylaxis but has significant toxicity. We assessed 139 consecutive HCT patients for PCP prophylaxis in our center. Read More

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November 2018
3 Reads

Further Lessons in Pneumocystis Pneumonia Prophylaxis-Reply.

JAMA Intern Med 2018 Nov;178(11):1566-1567

Sidney Kimmel Comprehensive Cancer Center, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Baltimore, Maryland.

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November 2018

Further Lessons in Pneumocystis Pneumonia Prophylaxis.

JAMA Intern Med 2018 Nov;178(11):1565-1566

Division of Rheumatology, Department of Medicine, University of California, San Francisco, San Francisco.

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November 2018

Prevalence and genotyping of Pneumocystis jirovecii in renal transplant recipients-preliminary report.

Parasitol Res 2018 Nov 3. Epub 2018 Nov 3.

Department of Biology and Medical Parasitology, Wroclaw Medical University, ul. J. Mikulicza-Radeckiego 9, 50-345, Wroclaw, Poland.

Pneumocystis jirovecii is an opportunistic fungus occurring in human lungs. The group at highest risk consists of HIV-infected and non-HIV-infected immunosuppressed individuals. In these patients, P. Read More

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November 2018
7 Reads

The presence of Pneumocystis jirovecii DNA in plasma is associated with a higher mortality rate in patients with AIDS-associated Pneumocystis pneumonia.

Med Mycol 2018 Oct 31. Epub 2018 Oct 31.

The Department of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

To examine the relationship between Pneumocystis jirovecii DNA (PJ-DNA) levels in blood from AIDS-associated Pneumocystis pneumonia (AIDS-PCP) and mortality, and to correlate mitochondrial large subunit rRNA (mtLSUrRNA) gene polymorphism with mortality, we performed a retrospective study including AIDS-PCP patients between 2014 and 2016 from one hospital in China. PJ-DNA in plasma was measured by nested polymerase chain reaction (PCR) of the mtLSUrRNA gene and in positive specimens we further detected the level of PJ-DNA using qPCR. Polymorphisms were observed at two positions (85 and 248) of the mtLSUrRNA gene by sequencing. Read More

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October 2018

Extracorporeal Membrane Oxygenation in a 29-Year-Old Man with Respiratory Failure and AIDS.

Tex Heart Inst J 2018 08 1;45(4):254-259. Epub 2018 Aug 1.

The use of extracorporeal membrane oxygenation (ECMO) in patients who have acute respiratory distress syndrome has been generally beneficial. However, because of various concerns, ECMO has rarely been used in patients who have human immunodeficiency virus infection with or without acquired immune deficiency syndrome. We report our successful use of venovenous ECMO in a 29-year-old man who presented with severe respiratory distress secondary to Pneumocystis jirovecii pneumonia associated with undiagnosed infection with the human immunodeficiency virus and acquired immune deficiency syndrome. Read More

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August 2018
4 Reads
0.630 Impact Factor

Pneumocystis jirovecii pneumonia (PCP) PCR-negative conversion predicts prognosis of HIV-negative patients with PCP and acute respiratory failure.

PLoS One 2018 25;13(10):e0206231. Epub 2018 Oct 25.

Division of Pulmonology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.

Background: Pneumocystis jirovecii pneumonia (PCP) is often fatal in human immunodeficiency (HIV)-negative patients and typically presents with respiratory insufficiency. Predicting treatment failure is challenging. This study aimed to identify prognostic factors and examine PCP polymerase chain reaction (PCR)-negative conversion in non-HIV PCP patients with respiratory failure. Read More

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October 2018
2 Reads

Independent losses and duplications of autophagy-related genes in fungal tree of life.

Environ Microbiol 2018 Oct 22. Epub 2018 Oct 22.

State Key Laboratory of Crop Stress Biology for Arid Areas and College of Plant Protection, Northwest A&F University, Yangling, Shaanxi, 712100, China.

Autophagy is important for growth, development and pathogenesis in fungi. Although autophagic process is generally considered to be conserved, the conservation and evolution of ATG genes at kingdom-wide remains to be conducted. Here we systematically identified 41 known ATG genes in 331 species and analyzed their distribution across the fungal kingdom. Read More

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October 2018

Clinical Profile of Pneumocystis jirovecii Infection - A Comparative Study.

J Assoc Physicians India 2018 Jan;66(1):28-31

Professor and Head, Department of Microbiology, Christian Medical College, Ludhiana, Punjab.

Objectives: Pneumocystis jirovecii pneumonia (PCP) can differ in HIV and non HIV population due to degree of immunity. This study was undertaken with an aim to highlight the differences between the two groups.

Methods: It was an observational study conducted in the department of Medicine of a tertiary care institution in North India. Read More

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January 2018
3 Reads

Severe acute respiratory distress syndrome in a patient with AIDS successfully treated with veno-venous extracorporeal membrane oxygenation: a case report and literature review.

Acute Med Surg 2018 Oct 19;5(4):384-389. Epub 2018 Aug 19.

Department of Emergency and Critical Care Medicine Tokyo Medical University Shinjuku Japan.

Case: Several successful uses of extracorporeal membrane oxygenation (ECMO) for acute respiratory distress syndrome in patients with novel HIV/AIDS infection have been reported; however, the therapeutic keys have not always been discussed.A 47-year-old man was admitted with progressive shortness of breath. He was in respiratory failure with a PaO/FO ratio of 110. Read More

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October 2018
4 Reads

[Risk factors and prophylaxis of Pneumocystis jirovecii pneumonia in HIV-negative patients].

Rev Med Suisse 2018 Oct;14(623):1829-1833

Service de médecine interne générale, HUG, 1211 Genève 14.

Pneumocystis jirovecii (formely carinii) pneumonia (PcP) affects immunosuppressed patients. Cotrimoxazole prophylaxis has proven to be effective and its indications in HIV patients are well established. In non-HIV patients, the prognosis is poorer and diagnostic tests are of lower sensitivity. Read More

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October 2018
1 Read

Binding of Pneumocystis carinii to the lung epithelial cell receptor HSPA5 (GRP78).

J Med Microbiol 2018 Dec 17;67(12):1772-1777. Epub 2018 Oct 17.

From the Thoracic Diseases Research Unit, Departments of Medicine and Biochemistry, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.

The importance of lung macrophages in Pneumocystis-host interaction is well known, but little is known about the initial binding/colonization of the airway epithelium. Our prior studies have documented cell-signalling events that occur following binding of the organisms to lung epithelial cells; however, the receptors that mediate Pneumocystis attachment to lung surfaces have not yet been fully defined. Using affinity chromatography, we identified heat shock protein 5 (HSPA5), also known as GRP78, as a potential host receptor that may have relevance in Pneumocystis lung colonization. Read More

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December 2018

Hospitalization Outcomes in Pneumocystis Pneumonia Inpatient Population: A Comparison between HIV and Non-HIV Patients.

Cureus 2018 Aug 1;10(8):e3082. Epub 2018 Aug 1.

Department of Psychiatry, Windsor University School of Medicine, Philadelphia, USA.

Objective To evaluate the difference in hospitalization outcomes, including morbidity and mortality among patients admitted for Pneumocystis pneumonia (PCP) with human immunodeficiency virus (HIV) and non-HIV condition. Methods A case-control study was done using the Healthcare Cost and Utilization Project (HCUP) Nationwide Inpatient Sample (NIS) data. We identified PCP and HIV as the primary and secondary diagnosis using ICD-9--CM diagnosis codes. Read More

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August 2018
1 Read

Idiopathic CD4 Lymphocytopenia with Fulminant Pneumocystis Jiroveci Pneumonia.

Am J Respir Crit Care Med 2018 Oct 15. Epub 2018 Oct 15.

Mayo Clinic Minnesota Department of Radiology, 198511, Radiology, Rochester, Minnesota, United States.

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October 2018

Importance of Timed and Detailed Evaluation of Kidney Transplantation Candidates.

Transplant Proc 2018 Oct 15;50(8):2350-2353. Epub 2018 Mar 15.

Department of Internal Medicine, Pusan National University Hospital, Busan, Republic of Korea; Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea. Electronic address:

Kidney transplant recipients are at increased risk of cardiovascular morbidity and malignant neoplasm, and meticulous evaluation of potential recipients is needed to minimize risks of complications after transplantation. The purpose of this study was to analyze the results of preoperative assessments and document the importance of timed and detailed examinations.

Methods: Medical records of patients evaluated as kidney transplant candidates from January 2015 to September 2017 were retrospectively collected and analyzed. Read More

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October 2018
6 Reads

Invasive fungal disease and cytomegalovirus infection: is there an association?

Curr Opin Infect Dis 2018 Dec;31(6):481-489

Department of Medicine, MD Anderson Cancer Center, University of Texas, Houston, USA.

Purpose Of Review: Invasive fungal disease (IFD) and cytomegalovirus (CMV) infections occur frequently, either concomitantly or sequentially in immune-compromised hosts. Although there is extensive knowledge of the risk factors for these infections as single entities, the inter-relationship between opportunistic fungii and CMV has not been comprehensively explored.

Recent Findings: Both solid organ and stem cell transplant recipients who develop CMV invasive organ disease are at an increased risk of developing IFD, particularly aspergillosis and Pneumocystis pneumonia (PCP). Read More

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December 2018
6 Reads

Airborne acquisition of Pneumocystis in bronchoscopy units: a hidden danger to healthcare workers.

Med Mycol 2018 Oct 4. Epub 2018 Oct 4.

Universidad de Sevilla, Spain.

The possible presence of Pneumocystis in a bronchoscopy unit of a tertiary-hospital was examined by detecting Pneumocystis-specific DNA by polymerase chain reaction in prospectively obtained samples of oropharyngeal wash from seven healthcare workers (HCWs) and air from three areas of the unit at different time points (baseline, days +15,+30,+60,+90 after initiation of the study). Positive samples were genotyped at two genetic loci: the mitochondrial large subunit ribosomal RNA (mtLSUrRNA) fragment by direct sequencing and the gene for dihydropteroate synthase (DHPS) by restriction fragment-length polymorphism. Pneumocystis DNA was identified in 13/24 samples from HCWs, in 4/14 air samples and also in two patients with Pneumocystis pneumonia (PcP) and another with a Pneumocystis-associated disease subjected to bronchoscopy on days +15 and +60 after initiation of the study. Read More

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October 2018
5 Reads

Correction: Development of highly active anti- bisbenzamidines: insight into the influence of selected substituents on the activity.

Medchemcomm 2017 Nov 7;8(11):2164. Epub 2017 Nov 7.

Division of Infectious Diseases , Department of Internal Medicine , University of Cincinnati College of Medicine , 231 Albert Sabin Way , Cincinnati , OH 45267 , USA . Email:

[This corrects the article DOI: 10.1039/C7MD00445A.]. Read More

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November 2017

Round opacity as a presentation of pneumocystis jirovecii pneumonia in an HIV-infected patient.

Am J Emerg Med 2018 Sep 30. Epub 2018 Sep 30.

Department of Internal Medicine, "Dr. José E. González" University Hospital of the School of Medicine of the Nuevo León Autonomous University, Monterrey, Mexico.

We present the case of a human immunodeficiency virus (HIV)-infected patient who arrived at our emergency department with fever, headache and exertional dyspnea. Throughout their stay, a chest x-ray was taken and a rounded opacity in his left lung was observed. CT images showed same abnormality and also ground glass opacities were seen. Read More

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September 2018
2 Reads

IL-10 Producing B Cells Regulate Th1/Th17 Cell Immune Responses in Pneumocystis Pneumonia.

Am J Physiol Lung Cell Mol Physiol 2018 Oct 4. Epub 2018 Oct 4.

Beijing Chao-Yang Hospital, China.

Pneumocystis pneumonia (PCP) is a common opportunistic infectious disease that is prevalent in immunosuppressed hosts. Accumulating evidence shows that B cells play an important role in infectious diseases. In the present study, the immune regulatory role of mature B cells in host defense to Pneumocystis was evaluated. Read More

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October 2018
2 Reads
4.080 Impact Factor

A Good Case of Recurrent Pneumonia.

J Investig Med High Impact Case Rep 2018 Jan-Dec;6:2324709618802869. Epub 2018 Sep 29.

Emory University School of Medicine, Atlanta, GA, USA.

infection is a common cause of pneumonia in animals but rarely causes disease in humans. Additionally, coinfection with is very uncommon and is occasionally seen in patients with acquired immunodeficiency syndrome (AIDS). We report a case of a 61-year-old HIV-negative man, who presented with hypoxic respiratory failure 2 days after completion of systemic intravenous antibiotic treatment for His past medical history was significant for a benign thymoma. Read More

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September 2018
2 Reads

Intrinsic Programming of Alveolar Macrophages for Protective Antifungal Innate Immunity Against Infection.

Front Immunol 2018 19;9:2131. Epub 2018 Sep 19.

Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY, United States.

Invasive fungal infections, including Pneumonia (PcP), remain frequent life-threatening conditions of patients with adaptive immune defects. While innate immunity helps control pathogen growth early during infection, it is typically not sufficient for complete protection against and other human fungal pathogens. Alveolar macrophages (AM) possess pattern recognition molecules capable of recognizing antigenic and structural determinants of . Read More

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September 2018
2 Reads

Correspondence Regarding the Article Titled "Low Lymphocyte Proportion in Bronchoalveolar Lavage Fluid as a Risk Factor Associated with the Change from Trimethoprim/sulfamethoxazole Used as First-Line Treatment for Pneumonia".

Authors:
Chang Hoon Lee

Infect Chemother 2018 Sep;50(3):263-265

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.

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September 2018

Therapeutic effect of ascorbic acid on dapsone-induced methemoglobinemia in rats.

Clin Exp Emerg Med 2018 Sep 30;5(3):192-198. Epub 2018 Sep 30.

Institute of Health Sciences, Gyeongsang National University, Jinju, Korea.

Objective: Dapsone (diaminodiphenyl sulfone, DDS) is currently used to treat leprosy, malaria, dermatitis herpetiformis, and other diseases. It is also used to treat pneumocystis pneumonia and Toxoplasma gondii infection in HIV-positive patients. The most common adverse effect of DDS is methemoglobinemia from oxidative stress. Read More

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September 2018
3 Reads

Echinocandins for pneumonia in non-HIV patients: A case report.

Exp Ther Med 2018 Oct 7;16(4):3227-3232. Epub 2018 Aug 7.

Medical Intensive Care Unit, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, P.R. China.

For the past two decades, echinocandins have shown prophylactic and therapeutic efficacy in patients with pneumonia (PJP), due to their ability to inhibit the synthesis of β-1, 3-glucan, a major component of the cell wall of . The present study reported two cases of human immunodeficiency virus (HIV)-negative patients who received echinocandins as a salvage therapy at Peking Union Medical College Hospital (Beijing, China), both of whom exhibited good responses to treatment. In both cases, polymerase chain reaction of sputum or bronchoalveolar lavage specimens became negative following treatment. Read More

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October 2018

Site-Directed Mutagenesis of the 1,3-β-Glucan Synthase Catalytic Subunit of and Susceptibility Assays Suggest Its Sensitivity to Caspofungin.

Antimicrob Agents Chemother 2018 Dec 26;62(12). Epub 2018 Nov 26.

Institute of Microbiology, Lausanne University Hospital, Lausanne, Switzerland

The echinocandin caspofungin inhibits the catalytic subunit Gsc1 of the enzymatic complex synthesizing 1,3-β-glucan, an essential compound of the fungal wall. Studies with rodents showed that caspofungin is effective against asci. However, its efficacy against asci of , the species infecting exclusively humans, remains controversial. Read More

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December 2018

Successful prevention of perinatal HIV transmission utilizing direct observation therapy in the setting of Acquired Immunodeficiency Syndrome (AIDS) and progressive multifocal leukoencephalopathy.

IDCases 2018 5;14:e00454. Epub 2018 Sep 5.

Hahnemann University Hospital, Drexel University College of Medicine, Philadelphia, PA, United States.

We report a case of a 22-year-old G1P0010 African-American female with poorly controlled perinatally acquired HIV/AIDS and recent diagnosis of progressive multifocal leukoencephalopathy (PML) by magnetic resonance imaging (MRI). She presented to a tertiary care facility for prenatal care and direct observation therapy after poor medication adherence during pregnancy. After multiple attempts at outpatient ART management, the patient was admitted at 35 weeks' gestation for direct observation therapy for both antiretroviral therapy and anti-seizure medication. Read More

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September 2018
11 Reads

The association between Cytomegalovirus co-infection with Pneumocystis pneumonia and mortality in immunocompromised non-HIV patients.

Clin Respir J 2018 Nov;12(11):2590-2597

Department of Medical Microbiology, Ege University Medical School, Izmir, Turkey.

Introduction: Impact of Cytomegalovirus (CMV) co-infection pneumonia in non-HIV patients with Pneumocystis jirovecii pneumonia (PCP) is unclear.

Objectives: The aim of our study was to determine whether CMV co-infection is associated with an increased risk of mortality.

Methods: Our study was conducted at Ege University Hospital, Turkey. Read More

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November 2018
2 Reads