698 results match your criteria Pneumocystis Carinii Imaging

Characteristics and outcomes of patients admitted to a tertiary academic hospital in Pretoria with HIV and severe pneumonia: a retrospective cohort study.

BMC Infect Dis 2022 Jun 15;22(1):548. Epub 2022 Jun 15.

Department of Medical Microbiology, University of Pretoria, Pretoria, South Africa.

Background: Human immunodeficiency virus (HIV) contributes significantly to morbidity and mortality in South Africa. Pneumonia and opportunistic infections remain a major cause for hospital admission among those living with HIV, even in the era of the widespread availability of antiretroviral therapy.

Methods: In this retrospective cohort study, the records of patients admitted with HIV and severe pneumonia, requiring high care/intensive care admission, during a period of 12 months (February 2018 to January 2019) were reviewed. Read More

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Severe pulmonary co-infection with varicella-zoster virus, : a case report.

J Int Med Res 2022 Jan;50(1):3000605211070759

Department of Critical Care Medicine, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, Shandong Province, China.

, and varicella-zoster virus are all opportunistically infective pathogens, but pulmonary co-infection with these pathogens is rare. Herein, this case report describes a patient with autoimmune haemolytic anaemia treated with methylprednisolone and cyclosporine that presented with rapidly progressive severe respiratory failure. Analysis of microbial nucleic acid sequences in both blood and sputum using next-generation sequencing revealed pulmonary co-infection with , varicella-zoster virus, and possibly . Read More

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January 2022

Super-resolution reconstruction of pneumocystis carinii pneumonia images based on generative confrontation network.

Comput Methods Programs Biomed 2022 Mar 8;215:106578. Epub 2021 Dec 8.

Fujian Provincial Key Laboratory of Data Intensive Computing, Quanzhou Normal University, Quanzhou 362000, China; Key Laboratory of Intelligent Computing and Information Processing, Quanzhou Normal University, Fujian Province University, Quanzhou 362000, China; Faculty of Mathematics and Computer Science, Quanzhou Normal University, Quanzhou 362000, China. Electronic address:

Objective: Pneumocystis carinii pneumonia, also known as pneumocystis carinii pneumonia (PCP), is an interstitial plasma cell pneumonia caused by pneumocystis spp. It is a conditional lung infectious disease. Because the early and correct diagnosis of PCP has a great influence on the prognosis of patients, the image processing of PCP's high-resolution CT (HRCT) is extremely important. Read More

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Detection of Pneumocystis jirovecii and Toxoplasma gondii in patients with lung infections by a duplex qPCR assay.

PLoS Negl Trop Dis 2021 12 17;15(12):e0010025. Epub 2021 Dec 17.

Beijing Institute of Tropical Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Pneumocystis pneumonia (PCP) and pulmonary toxoplasmosis (PT) are caused by Pneumocystis jirovecii and Toxoplasma gondii. The clinical symptoms and imaging of PCP and PT are indistinguishable. A duplex qPCR was developed to differentiate between these two pathogens. Read More

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December 2021

Case 35-2021: A 50-Year-Old Woman with Pain in the Left Upper Quadrant and Hypoxemia.

N Engl J Med 2021 Nov;385(21):1995-2001

From the Departments of Medicine (M.M.C., J.E.M.), Radiology (V.V.M.), and Pathology (M.N.A.), Massachusetts General Hospital, and the Departments of Medicine (M.M.C., J.E.M.), Radiology (V.V.M.), and Pathology (M.N.A.), Harvard Medical School - both in Boston.

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November 2021

Super-resolution of Pneumocystis carinii pneumonia CT via self-attention GAN.

Comput Methods Programs Biomed 2021 Nov 13;212:106467. Epub 2021 Oct 13.

Department of Laboratory Medicine, Zibo Central Hospital, No.54 West Gongqingtuan Road, Zhangdian District, Zibo City, Shandong Province, China. Electronic address:

Background And Objective: Computed tomography (CT) examination plays an important role in screening suspected and confirmed patients in pneumocystis carinii pneumonia (PCP), and the efficient acquisition of high-quality medical CT images is essential for the clinical application of computer-aided diagnosis technology. Therefore, improving the resolution of CT images of pneumonia is a very important task.

Methods: Aiming at the problem of how to recover the texture details of the reconstructed PCP CT super-resolution image, we propose the image super-resolution reconstruction model based on self-attention generation adversarial network (SAGAN). Read More

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November 2021

An Atypical (and Beautiful) Chest Computed Tomography of Pneumocystis jiroveci Pneumonia.

Gregory Wigger

Am J Med Sci 2022 01 30;363(1):e5. Epub 2021 Aug 30.

Division of Pulmonary, Allergy, Critical Care & Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA, United States. Electronic address:

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January 2022

Lung Ultrasound Effectively Detects HIV-Associated Interstitial Pulmonary Disease.

Int J Infect Dis 2021 Oct 15;111:204-210. Epub 2021 Aug 15.

Internal Medicine II, Department of Infectious Diseases, University Hospital Frankfurt, Germany.

Objectives To prospectively evaluate lung ultrasound in comparison with radiography and computed tomography (CT) for detecting HIV-related lung diseases. Methods Ultrasound examinations in HIV-positive patients were evaluated by three raters; available conventional imaging was evaluated by another rater. Results were compared with each other and the definite diagnosis. Read More

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October 2021

Semiquantitative Real-Time PCR to Distinguish Pneumocystis Pneumonia from Colonization in a Heterogeneous Population of HIV-Negative Immunocompromised Patients.

Microbiol Spectr 2021 09 4;9(1):e0002621. Epub 2021 Aug 4.

Department of Clinical and Molecular Medicine, NTNU, Trondheim, Norway.

Pneumocystis jirovecii is a threat to iatrogenically immunosuppressed individuals, a heterogeneous population at rapid growth. We assessed the ability of an in-house semiquantitative real-time PCR assay to discriminate Pneumocystis pneumonia (PCP) from colonization and identified risk factors for infection in these patients. Retrospectively, 242 PCR-positive patients were compared according to PCP status, including strata by immunosuppressive conditions, human immunodeficiency virus (HIV) infection excluded. Read More

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September 2021

Pneumocystis Pneumonia in a Patient with Ovarian Cancer Receiving Olaparib Therapy.

Intern Med 2022 Jan 10;61(2):217-221. Epub 2021 Jul 10.

Department of Anatomic Pathology, Miyazaki Prefectural Miyazaki Hospital, Japan.

We herein report a case of pneumocystis pneumonia (PCP) in a 77-year-old woman with ovarian cancer who was receiving olaparib therapy. After the patient's second relapse of ovarian cancer, she was administered olaparib as maintenance therapy following successful completion of docetaxel and carboplatin therapy. On receiving olaparib, she showed symptoms of a fever and malaise. Read More

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January 2022

Epidemiological and clinical characteristics of immunocompromised patients infected with Pneumocystis jirovecii in a twelve-year retrospective study from Norway.

BMC Infect Dis 2021 Jul 7;21(1):659. Epub 2021 Jul 7.

Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU - Norwegian University of Science and Technology, NO-7491, Trondheim, Norway.

Background: Pneumocystis pneumonia (PCP) severely menaces modern chemotherapy and immunosuppression. Detailed description of the epidemiology of Pneumocystis jirovecii today is needed to identify candidates for PCP-prophylaxis.

Methods: We performed a 12-year retrospective study of patients with P. Read More

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Radiological CT Patterns and Distribution of Invasive Pulmonary Aspergillus, Non-Aspergillus, Cryptococcus and Pneumocystis Jirovecii Mold Infections - A Multicenter Study.

Rofo 2021 Nov 25;193(11):1304-1314. Epub 2021 May 25.

Department of Interventional, Pediatric and Diagnostic Radiology, Inselspital, University of Bern, Switzerland.

Purpose:  Clinical signs and symptoms related to invasive fungal disease are nonspecific and need to be followed up by appropriate diagnostic procedures. The goal of this study was to analyze CT imaging patterns in invasive fungal infections and their correlation with the immune status and clinical outcome.

Materials And Methods:  We performed a retrospective multicenter study including 85 consecutive patients with invasive pulmonary fungal infection (2011-2014). Read More

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November 2021

Cavitary Pneumocystis jirovecii pneumonia.

QJM 2021 Nov;114(8):607-608

Department of Infectious Diseases, St Vincent's University Hospital, Dublin 4, Ireland.

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November 2021

Pneumocystis pneumonia causing cavitating lung nodules in an immunocompetent individual.

BMJ Case Rep 2021 Apr 27;14(4). Epub 2021 Apr 27.

Respiratory Medicine, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK.

Pneumocystis jirovecii pneumonia (PCP) is a potential life-threatening pulmonary infection which commonly manifests in immunosuppressed patients especially with HIV, with underlying malignancies, severe malnutrition as well as those on immunosuppressive treatments. There have been case reports of symptomatic PCP in individuals with a normally functioning immune system with typical clinical features and radiologic findings of bilateral and diffuse interstitial opacities. However, PCP in immunocompetent individuals presenting with lung nodules had been rarely reported. Read More

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Clinical descriptive analysis of severe pneumonia in renal transplantation recipients.

Bioengineered 2021 12;12(1):1264-1272

Department of General Intensive Care Unit, Lingnan Hospital, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China.

pneumonia (PJP) is an opportunistic fungal infection after renal transplantation, which is always severe, difficult to diagnose, combined with multiple complications and have poor prognosis. We retrospectively analyzed clinical data, including risk factors, diagnosis, treatment and complications of seven clinical cases suffered with severe PJP after renal transplantation in our department in 2019. All the seven recipients were routinely prescribed with PJP prophylaxis after renal transplantation, and six of them suffered acute graft rejection before the infection. Read More

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December 2021

Acute fibrinous and organizing pneumonia with myelodysplastic syndrome and pneumocystis jiroveci pneumonia: a case report.

Ann Palliat Med 2021 Jul 15;10(7):8396-8402. Epub 2021 Apr 15.

Department of Pulmonary and Critical Care Medicine, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing, China.

Acute fibrinous and organizing pneumonia (AFOP) is an unusual pathological pattern which is characterized by intra-alveolar deposition of fibrin (fibrin ball) and organizing pneumonia in a scattered distribution, and the pathological diagnosis plays an irreplaceable role in the diagnosis. Most Patients cannot confirm etiology, till now, known etiology included connective tissue disease, infection, environmental and occupational exposure, drugs, organ transplant, and tumor. It can be divided into acute and subacute subtype according to the extent of progress. Read More

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Unusual aetiology of respiratory compromise in a patient with AIDS.

BMJ Case Rep 2021 Mar 23;14(3). Epub 2021 Mar 23.

Internal Medicine, University of Florida College of Medicine-Jacksonville, Jacksonville, Florida, USA.

A 36-year-old African American man with no medical history presented with a recent history of cough and dyspnoea. Initial chest imaging revealed diffuse bilateral lung infiltrates. A subsequent HIV test resulted positive, and he was presumptively diagnosed with AIDS, later confirmed by a CD4 of 88 cells/mm Empiric therapy with trimethoprim-sulfamethoxazole was initiated for presumed pneumonia. Read More

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COVID-19 and Pneumocystis jirovecii pneumonia: Back to the basics.

Respir Med Res 2021 05 5;79:100814. Epub 2021 Feb 5.

Hôpital Foch, service de pneumologie, Suresnes, France; UPRES EA 220, université Paris-Saclay, Kremlin-Bicêtre, France.

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Increased mRNA expression of key cytokines among suspected cases of Pneumocystis jirovecii infection.

BMC Infect Dis 2021 Jan 7;21(1):28. Epub 2021 Jan 7.

Department of Microbiology and Clinical Parasitology, College of Medicine, King Khalid University, Abha, Saudi Arabia.

Background: Pneumocystis pneumonia (PCP) is a fatal infectious disease caused by Pneumocystis jirovecii (PJP). The major factor relevant to morbidity and mortality seems to be the host inflammatory reaction. The objective of this study was to evaluate the role of IL-2, IL-4, IL-10, and IL-13 cytokine mRNA expression among suspected P. Read More

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January 2021

Panniculitis in a Woman With Opportunistic Pulmonary Coinfection by Pneumocystis jirovecii and Cryptococcus neoformans: 18F-FDG PET/CT Revealing the Infection and Assessing Treatment Response.

Clin Nucl Med 2021 Apr;46(4):e210-e211

Pneumology, Rouen University Hospital.

Abstract: A 56-year-old woman, with history of psoriasis well controlled on ustekinumab, underwent 18F-FDG PET/CT to explore first onset of histologically proven skin panniculitis of unknown origin. PET/CT showed high uptake in panniculitis lesions in limbs and in a lung opacity suggestive of pneumonia. Based on PET/CT findings, a bronchoalveolar lavage revealed pulmonary coinfection by Pneumocystis jirovecii and Cryptococcus neoformans. Read More

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Clinical features and treatment outcomes of human immunodeficiency virus-associated cryptococcal meningitis: a 2-year retrospective analysis.

Chin Med J (Engl) 2020 Dec;133(23):2787-2795

Department of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.

Background: Cryptococcal meningitis (CM) is one of the most common opportunistic infections caused by Cryptococcus neoformans in human immunodeficiency virus (HIV)-infected patients, and is complicated with significant morbidity and mortality. This study retrospectively analyzed the clinical features, characteristics, treatment, and outcomes of first-diagnosed HIV-associated CM after 2-years of follow-up.

Methods: Data from all patients (n = 101) of HIV-associated CM hospitalized in Shanghai Public Health Clinical Center from September 2013 to December 2016 were collected and analyzed using logistic regression to identify clinical and microbiological factors associated with mortality. Read More

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December 2020

pneumonia, a COVID-19 mimic, reminds us of the importance of HIV testing in COVID-19.

Clin Med (Lond) 2020 11;20(6):590-592

University of Liverpool, Liverpool, UK and Royal Liverpool Hospital, Liverpool, UK

While clinical environments are highly focused on COVID-19, reports of missed or delayed treatment for conditions that imitate COVID-19, such as pneumonia caused by the fungus , are emerging. Given the uncertain spectrum of COVID-19 presentations and variable sensitivity of laboratory tests for SARS-CoV-2, there is a risk that, without a high index of suspicion, alternative aetiologies may be overlooked while pursuing a diagnosis of COVID-19. The British HIV Association has been calling for the inclusion of HIV testing in all patients admitted to hospital with suspected COVID-19. Read More

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November 2020

Bilateral pleural masses in an immunocompromised patient.

BMJ Case Rep 2020 Nov 4;13(11). Epub 2020 Nov 4.

Office of Faculty and Academic Affairs, University of Central Florida College of Medicine, Orlando, Florida, USA.

We present a case of persistent pleural masses with mediastinal adenopathy in an immunocompromised patient initially biopsied, diagnosed and treated for pneumonia, ultimately requiring surgical thoracoscopy to diagnose pulmonary histoplasmosis. We discuss the diagnostic approach for pleural masses in immunocompromised patients, the limitations of tissue sampling, interpretation and methodology, and pitfalls of testing in making a pathogen-specific diagnosis. Read More

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November 2020

Granulomatous Pneumocystis jirovecii mimics pulmonary metastasis in rectal cancer.

Kaohsiung J Med Sci 2021 01 15;37(1):74-75. Epub 2020 Oct 15.

Division of Thoracic Surgery, Department of Surgery, National Cheng Kung University Hospital, Tainan, Taiwan.

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January 2021

Next-generation sequencing technology for detecting pulmonary fungal infection in bronchoalveolar lavage fluid of a patient with dermatomyositis: a case report and literature review.

BMC Infect Dis 2020 Aug 17;20(1):608. Epub 2020 Aug 17.

Department of Infectious Diseases, the First Hospital, Jilin University, Changchun, 130021, Jilin, China.

Background: Invasive fungal pneumonia is a severe infectious disease with high mortality in immunocompromised patients. However, the clinical diagnosis of the pathogen(s) remains difficult since microbiological evidence is difficult to acquire.

Case Presentation: Here, we report a case of pulmonary fungal infection detected by next-generation sequencing (NGS) of bronchoalveolar lavage fluid (BALF) in a 61-year-old male with corticosteroid-treated dermatomyositis. Read More

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The many faces of interstitial pneumonia: a case of presumed SARS-CoV-2 infection.

Swiss Med Wkly 2020 06 11;150:w20312. Epub 2020 Jul 11.

Internal Medicine Department, Ospedale Regionale di Lugano, Ente Ospedaliero Cantonale, Switzerland / Pneumology Department, Ospedale Regionale di Lugano, Ente Ospedaliero Cantonale, Switzerland.

We present the case of an oncology patient admitted to our hospital during the current COVID-19 pandemic with clinical and radiological features strongly suggestive of interstitial pneumonia. Multiple laboratory tests were negative for SARS-CoV-2 (polymerase chain reaction testing of nasopharyngeal swabs, and of induced sputum and stool samples, investigation of serum immunoglobulins G and M). In the setting of an immunocompromised status due to recent chemotherapy cycles for lung adenocarcinoma and prolonged corticosteroid therapy (due to frequent exacerbations of chronic obstructive pulmonary disease in recent months), we actively searched for the pathological agent and found it to be Pneumocystis jirovecii. Read More

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A complex COVID-19 case with rheumatoid arthritis treated with tocilizumab.

Clin Rheumatol 2020 Sep 19;39(9):2797-2802. Epub 2020 Jun 19.

Department of Rheumatology and Immunology, Tongji Hospital, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan, 430030, China.

Recurrences of COVID-19 were observed in a patient with long-term usage of hydroxychloroquine, leflunomide, and glucocorticoids due to her 30-year history of rheumatoid arthritis (RA). Tocilizumab was applied and intended to target both COVID-19 and RA. However, disease of this patient aggravated after usage of tocilizumab. Read More

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September 2020

Characterization of Pneumocystis jirovecii pneumonia at three tertiary comprehensive hospitals in southern China.

Braz J Microbiol 2020 Sep 3;51(3):1061-1069. Epub 2020 May 3.

Jiangxi Provincial Key Laboratory of Medicine, Clinical Laboratory of the Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.

Due to the increasing use of immunosuppressant therapy, Pneumocystis jirovecii pneumonia (PJP) has become an emerging concern in human immunodeficiency virus (HIV)-negative patients. In this study, we conducted a retrospective study of 96 hospitalized patients with PJP from January 2015 to June 2019 at three tertiary comprehensive hospitals in Southern China. Information was collected regarding patient demographics, clinical manifestations, risk factors, laboratory analyses, radiological images, and treatment outcomes. Read More

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September 2020

Opportunistic coinfection with and associated with idelalisib treatment in a patient with chronic lymphocytic leukaemia.

BMJ Case Rep 2020 Apr 29;13(4). Epub 2020 Apr 29.

Division of Infectious Diseases, University of California San Francisco, San Francisco, California, USA.

We describe a case of opportunistic coinfections with and following treatment with idelalisib, a phosphoinositide 3-kinase inhibitor, for chronic lymphocytic leukaemia. This is the first case of pulmonary coccidioidomycosis reported in association with idelalisib. We review challenges related to diagnosis of opportunistic infections in this context. Read More

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