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Respir Med Case Rep 2018 9;25:270-273. Epub 2018 Oct 9.

Department of Internal Medicine, 123 Summer Street, Saint Vincent Hospital, Worcester, MA, 01608, USA.

Chest pain is a common symptom culminating in hospital admissions and specialist referrals. Although cardiac work up is pursued in most of the cases, cardiac etiology is found to be the culprit in minority of the cases. Acute chest pain is a clinical syndrome that may be caused by almost any condition affecting the thorax, abdomen, or internal organs. Read More

Rinsho Shinkeigaku 2017 09 31;57(9):485-491. Epub 2017 Aug 31.

Department of Neurology, Yamagata Prefectural Central Hospital.

We investigated 17 adult cases (14 males and 3 females) of myalgia induced by human parechovirus type 3 (HPeV3) infection, treated during the summers of 2008, 2011, 2014, and 2016. The patients were aged between 21 and 50 years. The limbs and trunk of all patients were affected, and severe myalgia, muscle weakness, and decreased grip strength were observed. Read More

BMC Musculoskelet Disord 2016 08 4;17:323. Epub 2016 Aug 4.

Department of Internal Medicine, Hyogo Prefectural Kaibara Hospital, Tamba, Japan.

Background: Epidemic myalgia is a disease that presents with fever and extreme myalgia of the trunk due to an acute enterovirus infection. The trunk pain is mainly in the chest or in the epigastrium. We aimed to highlight a case of epidemic myalgia where initial diagnosis needed differentiation from acute purulent spondylitis and discitis. Read More

Epidemiol Infect 2016 Apr 20;144(6):1286-90. Epub 2015 Nov 20.

Department of Microbiology,Yamagata Prefectural Institute of Public Health,Yamagata,Japan.

We previously reported an association between human parechovirus type 3 (HPeV3) and epidemic myalgia with myositis in adults during summers in which an HPeV3 outbreak occurred in children. However, this disease association has not yet been reported elsewhere. We have since continued our surveillance to accumulate data on this disease association and to confirm whether myalgia occurs in children as well as adults. Read More

Ther Umsch 2015 Jan;72(1):62-5

Hausarzt i. R., Interlaken.

Chest pain in ambulatory setting is predominantly not heart-associated. Most patients suffer from muskuloskeletal or functional (psychogenic) chest pain. Differential diagnosis covers aortic dissection, rib-fracture, shingles, GERD, Tietze-Syndrome, pulmonary embolism, pleuritis, pneumothorax, pleurodynia and metastatic disease. Read More

BMJ Case Rep 2014 Oct 13;2014. Epub 2014 Oct 13.

St Thomas' Hospital, London, UK.

We describe a case of a 42-year-old man who presented to the emergency department with severe left-sided chest pain and chest tenderness of 1-day duration. The pain was episodic and was aggravated by any chest wall movement. His initial blood tests and ECG were suggestive of acute coronary syndrome (ACS). Read More

Handb Clin Neurol 2014 ;123:379-416

Departments of Neurology and Microbiology, University of Illinois School of Medicine, Chicago, IL, USA.

J Clin Virol 2013 Oct 12;58(2):490-3. Epub 2013 Aug 12.

Laboratory of Clinical Virology, Department of Medical Microbiology, Academic Medical Center, Amsterdam, The Netherlands. Electronic address:

A 31 year-old woman presented with acute pain on the left side of the thorax and abdomen, radiating to the back together with fever, after she had returned from traveling in Southeast Asia. Except for pleural friction rub auscultated on the left hemithorax, no physical abnormalities were detected. We diagnosed a classical course of Bornholm disease, caused by an echovirus type 1. Read More

J Clin Virol 2013 Sep 20;58(1):188-93. Epub 2013 Jun 20.

Department of Microbiology, Yamagata Prefectural Institute of Public Health, Tokamachi 1-6-6, Yamagata 990-0031, Japan.

Background: Based on our findings in Yamagata, Japan, in 2008, we reported that human parechovirus type 3 (HPeV3) could be associated with epidemic myalgia among adults, although HPeV3 is generally associated with infectious diseases in children.

Objectives: To clarify the relationship between community outbreaks among children and myalgia through the continued surveillance of HPeV3 infections.

Study Design: In the summer season (June-August) of 2011, we collected 586 specimens from children with infectious diseases, and throat swabs, and stool and serum specimens from 5 patients with myalgia. Read More

Anc Sci Life 2012 Jan;31(3):107-16

Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka, India.

Background: Standardization of a compound Ayurvedic formulation is a critical and essential issue to be considered in assuring the therapeutic efficacy and safety and to rationalize their use in the health care. Sitopaladi churna is a reputed polyherbal formulation of Ayurveda. It is prescribed for the treatment of pleurodynia, intercostal neuralgia, cold, cough associated with bronchitis, pneumonia, tuberculosis, viral respiratory infection, and in pharyngeal and chest congestion. Read More

Emerg Infect Dis 2012 Nov;18(11):1787-93

Tokyo University of Agriculture and Technology Research and Education Center for Prevention of Global Infectious Diseases of Animals, Tokyo,

Human parechovirus has rarely been shown to cause clinical disease in adults. During June-August 2008, a total of 22 adults sought treatment at Yonezawa City Hospital in Yamagata, Japan, for muscle pain and weakness of all limbs; most also had fever and sore throat. All patients received a clinical diagnosis of epidemic myalgia; clinical laboratory findings suggested an acute inflammatory process. Read More

Int J Psychophysiol 2012 Dec 14;86(3):276-82. Epub 2012 Oct 14.

Centre for Musculoskeletal Research, University of Gävle, SE-801 76 Gävle, Sweden.

The aim of the study was to investigate autonomic nervous system regulation, physical activity (PA) and perceived stress and energy during daily activities in subjects with chronic muscle pain in the neck-shoulders (trapezius myalgia) (n=23) and symptom-free controls (n=22). Subjects underwent 24-hour objective ambulatory monitoring of heart rate variability (HRV) and PA, and reported their perceived stress and energy in a diary. Standard HRV measures were extracted in time and frequency domains. Read More

J Clin Virol 2012 Feb 19;53(2):93-6. Epub 2011 Dec 19.

Division of Infectious Diseases, Department of Pediatrics, Children's Hospital of Philadelphia, PA 19104, USA.

Indian J Med Microbiol 2011 Apr-Jun;29(2):110-7

Department of Virology, King Institute of Preventive Medicine, Guindy, Chennai 600 032, India.

Background: Coxsackie B viruses (genus, Enterovirus; family, Picornaviridae) can cause aseptic meningitis, encephalitis, pleurodynia, and fatal myocarditis, and are implicated in the pathogenesis of dilated cardiomyopathy. The differentiation of the group B Coxsackieviruses into their subtypes has potential clinical and epidemiological implications.

Objective: In this study, we developed a one-step, single-tube genogroup-specific reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay for the detection of group B Coxsackie genomes targeting 5' UTR region. Read More

J Paediatr Child Health 2011 Apr;47(4):242

J Microbiol Immunol Infect 2010 Dec;43(6):515-8

Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan.

Epidemic pleurodynia is seldom reported in Southeast Asia and there has been no report from Taiwan. We conducted a retrospective chart review of children = 18 years of age in the National Taiwan University Hospital from January 1 to December 31, 2005. Epidemic pleurodynia was defined as an acute illness characterized by sharp localized pain over the chest or upper abdomen. Read More

J Child Neurol 2010 Dec 7;25(12):1504-10. Epub 2010 Sep 7.

Cleveland Clinic, Cleveland, OH, USA.

The authors describe the demographics, clinical presentation, investigation, treatment, and outcomes of pediatric patients with Guillain-Barré syndrome. They identified 35 pediatric patients with Guillain-Barré syndrome presenting to a tertiary academic center over a 20-year period. The most common presenting symptoms were paresthesias (54%), weakness (49%), and myalgias (49%). Read More

Trans R Soc Trop Med Hyg 2009 Sep 4;103(9):871-7. Epub 2009 Jun 4.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, Niaosung Shiang, Kaohsiung, Taiwan.

To compare the clinical and laboratory characteristics and disease severity between adults and children with dengue in Taiwan in 2002, we retrospectively studied 661 serologically confirmed dengue-infected patients (606 adults and 55 children) admitted between June and December 2002 to a single medical centre. The medical charts of the patients were reviewed for demographic, clinical, laboratory and imaging information. Compared with children, adult patients were found to have: higher incidences of arthralgia (P<0. Read More

Mil Med 2008 Dec;173(12):1188-93

2D BN/1st Marines, 1st Marine Division (REIN), Box 555442, Camp Pendleton, CA 92055-5442, USA.

Classic dengue fever presents with a triad of fever, headache, and rash. A "saddleback" fever pattern, morbilliform rash with islets of sparing after apyrexia, and hematological/hepatic abnormalities are common findings. As the most common arbovirus infection, dengue is a significant health threat to deployed military forces worldwide. Read More

Am J Clin Oncol 2008 Aug;31(4):384-9

Pulmonary Clinic, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Objectives: The aim of pleurodesis in malignant pleural effusions is to prevent reaccumulation of the fluid, symptoms, and avoid the need for repeated hospitalization for thoracentesis. The purpose of this study was to evaluate the efficacy and safety of erythromycin as a pleural sclerosing agent.

Methods: Over a 2-year period, 34 patients with a symptomatic, recurrent, malignant pleural effusion who referred for chest tube drainage and pleurodesis were included. Read More

Praxis (Bern 1994) 2008 Jul;97(14):765-9

Coxsackieviruses are responsible for numerable diseases in man. This is also the reason for the high prevalence of endemic infection rates in the population. Our analysis (working hypothesis) will focus on the participation of Coxsackieviruses in chronic decompensated, complex tinnitus. Read More

Clin Microbiol Rev 2008 Jul;21(3):473-94

Infectious Diseases Division, Naval Medical Center, San Diego, California 92134-1005, USA.

Infectious myositis may be caused by a broad range of bacterial, fungal, parasitic, and viral agents. Infectious myositis is overall uncommon given the relative resistance of the musculature to infection. For example, inciting events, including trauma, surgery, or the presence of foreign bodies or devitalized tissue, are often present in cases of bacterial myositis. Read More

Southeast Asian J Trop Med Public Health 2007 Nov;38(6):1084-7

Department of Emergency Medicine, School of Medical Sciences, University Science of Malaysia, Health Campus, Kubang Kerian, Kelantan, Malaysia.

We describe a 5-year-old girl who had sudden onset difficulty in walking after 3 days of febrile illness. In the emergency department her creatine kinase level was elevated but urine myoglobin was normal. She was diagnosed as having benign acute childhood myositis. Read More

Orthopedics 2007 Mar;30(3):237-8

Department of Orthopedic Surgery and Sports Medicine, Temple University Hospital, 3401 N Broad St, 6th Fl OPB, Philadelphia, PA 19140, USA.

Dtsch Med Wochenschr 2006 Sep;131(39):2143-6

Klinik für Innere Medizin-Schwerpunkt Kardiologie der Universitätsklinikums GmbH Gissen und Marburg, Standort Marburg.

History: A 36 year-old man suffered from fever, fatigue, pleurodynia and precordial discomfort. His family physician suspected febrile tracheobronchitis and treated it with ampicillin for 5 days. Because symptoms persisted an ECG was done which suggested acute myocardial infarction. Read More

MMW Fortschr Med 2005 Oct;147(40):45-6

FriedrichBaur-Institut, Neurologische Klinik der LMU München.

Eur J Neurol 2005 Aug;12(8):660

Ann Pharmacother 2005 Apr 1;39(4):757-60. Epub 2005 Mar 1.

Section of Internal Medicine, Department of Internal Medicine and Public Medicine, University Medical School of Bari, Bari, Italy.

Objective: To report a case of central fever associated with severe myalgia following esomeprazole.

Case Summary: A 64-year-old man presented with intense cephalalgia; severe, diffuse myalgia; and fever (>40 degrees C) after esomeprazole initiation for treatment of gastritis. Five hours after ingestion of the first esomeprazole pill (40 mg), the patient developed fever associated with cephalalgia and myalgia. Read More

Clin J Pain 2004 Nov-Dec;20(6):440-6

Department of Occupational and Environmental Medicine, University Hospital, Lund, Sweden.

Objectives: Pathomechanisms of work-related myalgia are poorly understood. Myalgia is thought to be caused by excitation of nociceptors present in the muscular tissue but not in the muscle fiber itself. Muscle contraction in combination with hypoxia is known to excite nociceptors. Read More

J Virol Methods 2004 Sep;120(2):167-72

Department of Microbiology, Sanjay Gandhi Post Graduate Institute of Medical sciences (S.G.P.G.I.M.S.), Lucknow 226 014, India.

Coxsackie B viruses (genus, Enterovirus; family, Picornaviridae) can cause aseptic meningitis, encephalitis, pleurodynia, myocarditis and are implicated in the pathogenesis of dilated cardiomyopathy. The differentiation of the group B coxsackieviruses into their subtypes has potential clinical and epidemiological implications. In the present study, a simple restriction fragment length polymorphism (RFLP) assay was developed for typing of group B coxsackieviruses into subtypes 1-6. Read More

Nihon Naika Gakkai Zasshi 2004 Jun;93(6):1180-2

Department of Internal Medicine, Sakuma Hospital, Shizuoka.

Med Lett Drugs Ther 2003 Dec;45(1171):97-8

Med Lett Drugs Ther 2003 Oct;45(1167):81-3

Kansenshogaku Zasshi 2003 Jul;77(7):505-9

First Department of Internal Medicine, Ehime University, School of Medicine.

A 45-year-old man visited the first hospital complained of high fever on January 2003. He was diagnosed as having Influenza virus type A infection and prescribed of Oseltamivir. He was afebrile next day, but severe myalgia of neck, shoulder, lumbar region and right femoral region was appeared. Read More

Expert Opin Drug Saf 2002 May;1(1):65-70

Department of Rheumatology, Groupe Hospitalier Pellegrin, 33076 Bordeaux Cedex, France.

Drug-induced muscle disorders represent a broad clinical spectrum, from asymptomatic elevated serum creatine kinase levels to life-threatening myopathies. An increasing number of drugs have been suspected or identified as myotoxic. It would be unrealistic to attempt to list them. Read More

Oncology (Williston Park) 2003 Feb;17(2):271-7; discussion 281-2, 286-8

Department of Pharmacy, University of Washington, Seattle Cancer Care Alliance, Seattle, Washington, USA.

Paclitaxel-induced myalgias and arthralgias occur in a significant fraction of patients receiving therapy with this taxane, potentially impairing physical function and quality of life. Paclitaxel-induced myalgias and arthralgias are related to individual doses; associations with the cumulative dose and infusion duration are less clear. Identification of risk factors for myalgias and arthralgias could distinguish a group of patients at greater risk, leading to minimization of myalgias and arthralgias through the use of preventive therapies. Read More

Int J Clin Oncol 2003 Feb;8(1):45-8

Department of Obstetrics and Gynecology, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan.

Background: The aim of this study was to evaluate the toxicity and efficacy of weekly paclitaxel in patients with recurrent endometrial cancer.

Methods: Nine patients with recurrent endometrial cancer who had previously received chemotherapy or radiotherapy participated in the study, between May 1999 and August 2001. Paclitaxel was given at a dose of 70 mg/m(2) as a 1-h infusion every week for at least 20 consecutive weeks unless lesions became progressive. Read More

Semin Pediatr Infect Dis 2002 Jan;13(1):55-63

Department of Pediatrics, Baylor College of Medicine, Houston, TX 77023, USA.

In 1954, the Nobel Prize for Medicine was awarded to Drs John Enders, Thomas Weller, and Frederick Robbins for their watershed discovery that growth of poliomyelitis virus occurred in cultures of cells of extraneural origin, first reported in 1949. Their demonstration in 1949 that the Lansing type II strain of poliomyelitis could be grown in cultures of human embryonic tissue set into motion a race to develop a vaccine for the disease that had crippled countless thousands of individuals. The discovery and subsequent recognition were only the beginning of a prolific career for Thomas Huckle Weller, who made numerous contributions to the field of virology, including isolating the varicella-zoster virus (VZV) from cases of chickenpox and zoster, providing suggestive evidence that the same virus is responsible for both diseases; isolating the human cytomegalovirus (CMV) for the first time in tissue culture and suggesting the descriptive name now used for it; establishing Coxsackie viruses as the cause of epidemic pleurodynia: and first isolating rubella virus, the cause of German measles. Read More

Ryoikibetsu Shokogun Shirizu 2001 (36):467-72

Nishino Clinic of Pediatric & Allergic Diseases.

J R Soc Med 2001 Oct;94(10):536-40

University of Western Australia, Department of General Practice, 328 Stirling Way, Claremont 6010, Australia.

Aust Fam Physician 2000 Jan;29(1):51-2

Kintore Clinic, Katherine, Northern Territory.

Ryoikibetsu Shokogun Shirizu 1999 (24 Pt 2):147-8

Department of Neurology, Kurume University Medical Center.

Ann Pharmacother 1998 Nov;32(11):1165-7

Department of Pharmaceutical Care, University of Iowa Hospitals and Clinics, College of Pharmacy, University of Iowa, Iowa City, USA.

Objective: To document a case of severe, progressive myopathy, myalgias, arthralgias, and weakness possibly caused by amlodipine in a patient with benign essential hypertension.

Case Summary: A 52-year-old white woman with asthma and newly diagnosed hypertension was initiated on zafirlukast therapy for asthma and amlodipine therapy for hypertension. Two months later, the patient reported severe, generalized muscle and joint pain, muscle stiffness, and weakness. Read More

Pediatrics 1998 Nov;102(5):1126-34

University of Rochester Medical Center, Rochester, New York, USA.

Objective: To characterize the acute clinical course and economic burden of nonpolio enteroviral (NPEV) illness in the summer/fall season as seen in private pediatric practice.

Methods: We prospectively studied 380 children aged 4 to 18 years with systemic NPEV syndromes presenting to private suburban pediatric practices. Seventy-three asymptomatic controls were concurrently enrolled. Read More

J Rheumatol 1998 Aug;25(8):1653-4

Rev Rhum Engl Ed 1998 Apr;65(4):288-90

Pediatr Neurol 1998 Mar;18(3):272-4

Division of Pediatric Surgery, University of Vienna Medical School, Austria.

This study reports an 8-year-old boy with chronic recurring thoracic pain. Magnetic resonance imaging of the spine revealed an intradural cyst at T1-T2. Despite severe compression of the spinal cord, there was no neurologic deficit. Read More

J Ark Med Soc 1997 Sep;94(4):167-8

Department of Internal Medicine, UAMS, USA.

Schweiz Med Wochenschr 1995 Sep;125(38):1793-8

Minerva Chir 1994 Nov;49(11):1077-82

Cattedra e Scuola di Specializzazione di Chirurgia Toracica, Università degli Studi, Pisa.

From June 1989 to December 1991, 93 patients affected by malignant pleural effusion (MPE) were treated as out patients using a ultrasound (US) guided catheter drainage (10F Percuflex pig-tail catheter-Medi-tech@(PTC) and chemical pleurodesis. The PTC was positioned when the MPE had been diagnosed by X-ray and all the patients had undergone some thoracentesis (mean 3.2, range 2-6). Read More