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J Surg Case Rep 2022 Mar 15;2022(3):rjac074. Epub 2022 Mar 15.

Department of Microbiology, Immunology and Pharmacology School of Medicine, St. George's University, Grenada, West Indies.

A 41-year-old female presented with an 8-month history of right upper quadrant pain, exacerbated by ingestion of saturated fats. The patient was positive for antibodies to Coxsackievirus serotype B4, established by an investigation incited by an acute episode of pleurodynia 8 months before the current presentation. Imaging studies including a hepatobiliary iminodiacetic acid scan showed no gallbladder structural or functional abnormalities. Read More

J Ethnopharmacol 2021 Dec 12;281:114519. Epub 2021 Aug 12.

Department of Marine Food Science and Technology, Gangneung-Wonju National University, 120 Gangneung, Gangwon, 210-702, Republic of Korea; East Coast Life Sciences Institute, Gangneung-Wonju National University, 120 Gangneung, Gangwon, 210-702, Republic of Korea. Electronic address:

Ethnopharmacological Relevance: Taraxacum platycarpum Dahlst. (Korean dandelion) is a medicinal herb used in traditional medicine in Korea to treat various disease such as furuncles, mammitis, hepatitis, jaundice. Moreover, a decoction prepared from T. Read More

Monaldi Arch Chest Dis 2020 Nov 2;90(4). Epub 2020 Nov 2.

Respiratory Department, Papageorgiou General Hospital, Thessaloniki.

Behcet's disease (BD) is a vasculitis of unknown etiology. It is often correlated with thrombophilic factors such as V Leiden. Pulmonary involvement is reported in 1-10% of patients. Read More

Muscle Nerve 2021 01 12;63(1):E1-E2. Epub 2020 Oct 12.

Department of Neuroscience, Imaging and Clinical Sciences, University "G. d'Annunzio", Chieti, Italy.

Intern Med 2020 Jul 16;59(14):1721-1726. Epub 2020 Apr 16.

Department of Neurology, Japanese Red Cross Medical Center, Japan.

Objective Epidemic myalgia associated with human parechovirus type 3 (EM-HPeV3) is characterized by severe muscle pain and weakness on the limbs and trunk with a fever. No outbreak of EM-HPeV3 has been reported since 2016, and its clinical characteristics have not been sufficiently clarified. We herein report a series of EM-HPeV3 cases during the summer of 2019 and clarify the clinical characteristics of EM-HPeV3. Read More

Trop Anim Health Prod 2019 Nov 10;51(8):2127-2137. Epub 2019 May 10.

Department of Molecular and Integrative Physiology, University of Illinois, Urbana-Champaign, Champaign, IL, 61801, USA.

Therapeutic management of contagious caprine pleuroneumonia (CCPP) involves mostly the use of oxytetracycline followed by enrofloxacin and rarely tylosin. In many parts of the world including India, the former antibiotics are commonly available than the latter. Therefore, prolonged use of the same leads to the development of antibiotic resistance and decreased efficacy of drug. Read More

Vet Q 2019 Dec;39(1):1-25

f Animal Health Division , Central Institute for Research on Goats (CIRG) , Mathura , India.

Contagious caprine pleuropneumonia (CCPP) is a serious disease of goats, occasionally sheep and wild ruminants, caused by Mycoplasma capricolum subspecies capripneumoniae (Mccp). The disease is characterized by severe serofibrinous pleuropneumonia, very high morbidity (∼100%), and mortality (80-100%). CCPP affects goats in more than 40 countries of the world thereby posing a serious threat to goat farming around the globe. Read More

Clin Pediatr (Phila) 2019 04 28;58(4):482-484. Epub 2019 Jan 28.

3 Children's Hospital, University of Illinois at Chicago College of Medicine, Chicago, IL, USA.

Respir Med Case Rep 2018 9;25:270-273. Epub 2018 Oct 9.

Department of Internal Medicine, 123 Summer Street, Saint Vincent Hospital, Worcester, MA, 01608, USA.

Chest pain is a common symptom culminating in hospital admissions and specialist referrals. Although cardiac work up is pursued in most of the cases, cardiac etiology is found to be the culprit in minority of the cases. Acute chest pain is a clinical syndrome that may be caused by almost any condition affecting the thorax, abdomen, or internal organs. Read More

BMC Infect Dis 2018 08 7;18(1):381. Epub 2018 Aug 7.

Department of Infection Control, Fukushima Medical University, 1 Hikarigaoka, Fukushima, 960-1295, Japan.

Background: Human parechovirus type 3 (HPeV-3) is known to cause cold-like symptoms, diarrhea, or severe infections such as sepsis in infants and children. In adults, HPeV-3 infection is rarely diagnosed because the symptoms are generally mild and self-limiting; however, this infection has been linked to epidemic myalgia, regardless of the presence of underlying diseases, immunosuppression, or sex.

Case Presentation: We describe an adult case of severe systemic myalgia and orchiodynia after infection with HPeV-3, which was transmitted from the child of the patient. Read More

Rinsho Shinkeigaku 2017 09 31;57(9):485-491. Epub 2017 Aug 31.

Department of Neurology, Yamagata Prefectural Central Hospital.

We investigated 17 adult cases (14 males and 3 females) of myalgia induced by human parechovirus type 3 (HPeV3) infection, treated during the summers of 2008, 2011, 2014, and 2016. The patients were aged between 21 and 50 years. The limbs and trunk of all patients were affected, and severe myalgia, muscle weakness, and decreased grip strength were observed. Read More

BMC Musculoskelet Disord 2016 08 4;17:323. Epub 2016 Aug 4.

Department of Internal Medicine, Hyogo Prefectural Kaibara Hospital, Tamba, Japan.

Background: Epidemic myalgia is a disease that presents with fever and extreme myalgia of the trunk due to an acute enterovirus infection. The trunk pain is mainly in the chest or in the epigastrium. We aimed to highlight a case of epidemic myalgia where initial diagnosis needed differentiation from acute purulent spondylitis and discitis. Read More

Epidemiol Infect 2016 Apr 20;144(6):1286-90. Epub 2015 Nov 20.

Department of Microbiology,Yamagata Prefectural Institute of Public Health,Yamagata,Japan.

We previously reported an association between human parechovirus type 3 (HPeV3) and epidemic myalgia with myositis in adults during summers in which an HPeV3 outbreak occurred in children. However, this disease association has not yet been reported elsewhere. We have since continued our surveillance to accumulate data on this disease association and to confirm whether myalgia occurs in children as well as adults. Read More

Ther Umsch 2015 Jan;72(1):62-5

Hausarzt i. R., Interlaken.

Chest pain in ambulatory setting is predominantly not heart-associated. Most patients suffer from muskuloskeletal or functional (psychogenic) chest pain. Differential diagnosis covers aortic dissection, rib-fracture, shingles, GERD, Tietze-Syndrome, pulmonary embolism, pleuritis, pneumothorax, pleurodynia and metastatic disease. Read More

BMJ Case Rep 2014 Oct 13;2014. Epub 2014 Oct 13.

St Thomas' Hospital, London, UK.

We describe a case of a 42-year-old man who presented to the emergency department with severe left-sided chest pain and chest tenderness of 1-day duration. The pain was episodic and was aggravated by any chest wall movement. His initial blood tests and ECG were suggestive of acute coronary syndrome (ACS). Read More

Handb Clin Neurol 2014 ;123:379-416

Departments of Neurology and Microbiology, University of Illinois School of Medicine, Chicago, IL, USA.

J Clin Virol 2013 Oct 12;58(2):490-3. Epub 2013 Aug 12.

Laboratory of Clinical Virology, Department of Medical Microbiology, Academic Medical Center, Amsterdam, The Netherlands. Electronic address:

A 31 year-old woman presented with acute pain on the left side of the thorax and abdomen, radiating to the back together with fever, after she had returned from traveling in Southeast Asia. Except for pleural friction rub auscultated on the left hemithorax, no physical abnormalities were detected. We diagnosed a classical course of Bornholm disease, caused by an echovirus type 1. Read More

J Clin Virol 2013 Sep 20;58(1):188-93. Epub 2013 Jun 20.

Department of Microbiology, Yamagata Prefectural Institute of Public Health, Tokamachi 1-6-6, Yamagata 990-0031, Japan.

Background: Based on our findings in Yamagata, Japan, in 2008, we reported that human parechovirus type 3 (HPeV3) could be associated with epidemic myalgia among adults, although HPeV3 is generally associated with infectious diseases in children.

Objectives: To clarify the relationship between community outbreaks among children and myalgia through the continued surveillance of HPeV3 infections.

Study Design: In the summer season (June-August) of 2011, we collected 586 specimens from children with infectious diseases, and throat swabs, and stool and serum specimens from 5 patients with myalgia. Read More

Anc Sci Life 2012 Jan;31(3):107-16

Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka, India.

Background: Standardization of a compound Ayurvedic formulation is a critical and essential issue to be considered in assuring the therapeutic efficacy and safety and to rationalize their use in the health care. Sitopaladi churna is a reputed polyherbal formulation of Ayurveda. It is prescribed for the treatment of pleurodynia, intercostal neuralgia, cold, cough associated with bronchitis, pneumonia, tuberculosis, viral respiratory infection, and in pharyngeal and chest congestion. Read More

Emerg Infect Dis 2012 Nov;18(11):1787-93

Tokyo University of Agriculture and Technology Research and Education Center for Prevention of Global Infectious Diseases of Animals, Tokyo,

Human parechovirus has rarely been shown to cause clinical disease in adults. During June-August 2008, a total of 22 adults sought treatment at Yonezawa City Hospital in Yamagata, Japan, for muscle pain and weakness of all limbs; most also had fever and sore throat. All patients received a clinical diagnosis of epidemic myalgia; clinical laboratory findings suggested an acute inflammatory process. Read More

Int J Psychophysiol 2012 Dec 14;86(3):276-82. Epub 2012 Oct 14.

Centre for Musculoskeletal Research, University of Gävle, SE-801 76 Gävle, Sweden.

The aim of the study was to investigate autonomic nervous system regulation, physical activity (PA) and perceived stress and energy during daily activities in subjects with chronic muscle pain in the neck-shoulders (trapezius myalgia) (n=23) and symptom-free controls (n=22). Subjects underwent 24-hour objective ambulatory monitoring of heart rate variability (HRV) and PA, and reported their perceived stress and energy in a diary. Standard HRV measures were extracted in time and frequency domains. Read More

J Clin Virol 2012 Feb 19;53(2):93-6. Epub 2011 Dec 19.

Division of Infectious Diseases, Department of Pediatrics, Children's Hospital of Philadelphia, PA 19104, USA.

Indian J Med Microbiol 2011 Apr-Jun;29(2):110-7

Department of Virology, King Institute of Preventive Medicine, Guindy, Chennai 600 032, India.

Background: Coxsackie B viruses (genus, Enterovirus; family, Picornaviridae) can cause aseptic meningitis, encephalitis, pleurodynia, and fatal myocarditis, and are implicated in the pathogenesis of dilated cardiomyopathy. The differentiation of the group B Coxsackieviruses into their subtypes has potential clinical and epidemiological implications.

Objective: In this study, we developed a one-step, single-tube genogroup-specific reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay for the detection of group B Coxsackie genomes targeting 5' UTR region. Read More

J Paediatr Child Health 2011 Apr;47(4):242

J Microbiol Immunol Infect 2010 Dec;43(6):515-8

Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan.

Epidemic pleurodynia is seldom reported in Southeast Asia and there has been no report from Taiwan. We conducted a retrospective chart review of children = 18 years of age in the National Taiwan University Hospital from January 1 to December 31, 2005. Epidemic pleurodynia was defined as an acute illness characterized by sharp localized pain over the chest or upper abdomen. Read More

J Child Neurol 2010 Dec 7;25(12):1504-10. Epub 2010 Sep 7.

Cleveland Clinic, Cleveland, OH, USA.

The authors describe the demographics, clinical presentation, investigation, treatment, and outcomes of pediatric patients with Guillain-Barré syndrome. They identified 35 pediatric patients with Guillain-Barré syndrome presenting to a tertiary academic center over a 20-year period. The most common presenting symptoms were paresthesias (54%), weakness (49%), and myalgias (49%). Read More

Trans R Soc Trop Med Hyg 2009 Sep 4;103(9):871-7. Epub 2009 Jun 4.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, Niaosung Shiang, Kaohsiung, Taiwan.

To compare the clinical and laboratory characteristics and disease severity between adults and children with dengue in Taiwan in 2002, we retrospectively studied 661 serologically confirmed dengue-infected patients (606 adults and 55 children) admitted between June and December 2002 to a single medical centre. The medical charts of the patients were reviewed for demographic, clinical, laboratory and imaging information. Compared with children, adult patients were found to have: higher incidences of arthralgia (P<0. Read More

Mil Med 2008 Dec;173(12):1188-93

2D BN/1st Marines, 1st Marine Division (REIN), Box 555442, Camp Pendleton, CA 92055-5442, USA.

Classic dengue fever presents with a triad of fever, headache, and rash. A "saddleback" fever pattern, morbilliform rash with islets of sparing after apyrexia, and hematological/hepatic abnormalities are common findings. As the most common arbovirus infection, dengue is a significant health threat to deployed military forces worldwide. Read More

Am J Clin Oncol 2008 Aug;31(4):384-9

Pulmonary Clinic, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Objectives: The aim of pleurodesis in malignant pleural effusions is to prevent reaccumulation of the fluid, symptoms, and avoid the need for repeated hospitalization for thoracentesis. The purpose of this study was to evaluate the efficacy and safety of erythromycin as a pleural sclerosing agent.

Methods: Over a 2-year period, 34 patients with a symptomatic, recurrent, malignant pleural effusion who referred for chest tube drainage and pleurodesis were included. Read More