71,170 results match your criteria Pleural Effusion


Efficacy and safety of partial splenic embolization for hypersplenism in pre- and post-liver transplant patients: A 16-year comparative analysis.

Clin Imaging 2018 Nov 27;54:71-77. Epub 2018 Nov 27.

Department of Radiology, Division of Vascular and Interventional Radiology, Columbia University Medical Center, 177 Fort Washington Ave, Milstein Hospital - 4 Hudson North, New York, NY 10032, United States of America.

Purpose: To report the effect of partial splenic embolization (PSE) on hematological indices and the procedure's safety in pre- and post-liver transplant (LT) patients.

Materials And Methods: A single-center retrospective study evaluating all patients who underwent PSE over a 16-year period was performed. Inclusion criteria were splenomegaly confirmed by imaging and at least one of the following cytopenias: hemoglobin ≤10 g/dL, WBC count ≤1500 μL, or platelet count ≤100,000 μL. Read More

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November 2018
1 Read

One-stage transmediastinal surgical approach for extensive aortic pathology.

Multimed Man Cardiothorac Surg 2018 Dec 4;2018. Epub 2018 Dec 4.

SS. Antonio e Biagio e Cesare Arrigo Hospital of Alessandria Piedmont Italy.

"One-stage" transmediastinal replacement of the thoracic aorta provides an alternative treatment to single or multiple stage hybrid procedures for patients with ascending, arch, and descending thoracic aorta aneurysm. The patient is placed on bypass and cooled. During circulatory arrest, after surgical treatment of the aortic valve and root where appropriate, the entire ascending aorta is excised and the transverse arch is opened longitudinally. Read More

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December 2018

Veterinary-focused assessment with sonography for trauma-airway, breathing, circulation, disability and exposure: a prospective observational study in 64 canine trauma patients.

J Small Anim Pract 2018 Dec 13. Epub 2018 Dec 13.

Lodi's ICU and Sub ICU Head, ASST Lodi 26900, Italy.

Objective: To describe the technique and findings of the 'veterinary focused assessment with sonography for trauma-airway, breathing, circulation, disability and exposure' protocol in dogs suffering from trauma.

Materials And Methods: Prospective observational study on a new point-of-care ultrasound protocol on 64 dogs suffering from trauma and comparison of findings with radiology.

Results: Comparison of the results of this new ultrasound protocol for trauma patients with radiography findings for pneumothorax, pleural effusion, alveolar-interstitial syndrome and abdominal effusion revealed positive agreement of 89, 83, 100 and 87% and negative agreement of 76, 83, 76 and 92%, respectively. Read More

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December 2018
1 Read

High- and Ultra-High definition of IR spectral histopathology gives an insight into chemical environment of lung metastases in breast cancer.

J Biophotonics 2018 Dec 12:e201800345. Epub 2018 Dec 12.

Faculty of Chemistry, Jagiellonian University, Poland.

Using high- (HD) and ultra-high-definition (UHD) of Fourier Transform Infrared (FTIR) spectroscopic imaging, we characterised spectrally pulmonary metastases in a murine model of breast cancer comparing them with histopathological results (H&E staining). This comparison showed excellent agreement between the methods in case of localisation of metastases with size below 1 mm and revealed that label-free HD and UHD IR spectral histopathology distinguish the type of neoplastic cells. We primary focused on differentiation between metastatic foci in the pleural cavity from cancer cells present in lung parenchyma and inflamed cells present in extracellular matrix of lungs due to growing of advanced metastases. Read More

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December 2018

The bacteriology in adult patients with pneumonia and parapneumonic effusions: increased yield with DNA sequencing method.

Eur J Clin Microbiol Infect Dis 2018 Dec 13. Epub 2018 Dec 13.

Department of Medicine, Solna, Infectious Diseases Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.

The aim of this study was to use a 16S rDNA sequencing method in combination with conventional culture in patients with parapneumonic effusions (PPE) to evaluate the methods, study the microbiological spectrum, and examine the presence of bacteria within the different stages of PPE. Adults with community-acquired pneumonia (CAP) and PPE (n = 197) admitted to the Departments of Infectious Diseases at four hospitals in Stockholm County during 2011-2014 were prospectively studied. All patients underwent thoracentesis. Read More

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December 2018

Chordoma of the mobile spine and sacrum: clinical management and prognosis.

J Spine Surg 2018 Sep;4(3):546-552

Department of Orthopaedic Surgery, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.

Background: Chordomas are rare malignant tumors of the spinal column often afflicting the upper cervical spine and sacrum. There are few large single center series on chordomas due to its rarity. The purpose of this study is to report a single center's experience with the operative and non-operative management of chordomas. Read More

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September 2018
2 Reads

What's hot that the other lot got.

Authors:
Andrew C Kidd

Thorax 2019 Jan;74(1):100

Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK.

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January 2019

Vascular Injury Is a Major Cause of Lung Injury After Balloon Pulmonary Angioplasty in Patients With Chronic Thromboembolic Pulmonary Hypertension.

Circ Cardiovasc Interv 2018 Dec;11(12):e005884

Department of Cardiology (K.E., S.F., H.M.), National Hospital Organization Okayama Medical Center, Japan.

Background: Balloon pulmonary angioplasty (BPA) has become an alternative treatment for inoperable patients with chronic thromboembolic pulmonary hypertension. Lung injury (LI) is a major complication of BPA and may attenuate the benefits of BPA. Therefore, we conducted a retrospective study to evaluate the association between patient and procedural characteristics and LI in patients with chronic thromboembolic pulmonary hypertension. Read More

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December 2018

The Role of Yes-Associated Protein (YAP) in Regulating Programmed Death-Ligand 1 (PD-L1) in Thoracic Cancer.

Biomedicines 2018 Dec 7;6(4). Epub 2018 Dec 7.

Department of Surgery, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94115, USA.

The programmed death-ligand 1(PD-L1)/PD-1 pathway is an immunological checkpoint in cancer cells. The binding of PD-L1 and PD-1 promotes T-cell tolerance and helps tumor cells escape from host immunity. Immunotherapy targeting the PD-L1/PD-1 axis has been developed as an anti-cancer therapy and used in treating advanced human non-small cell lung cancer (NSCLC) and malignant pleural mesothelioma (MPM). Read More

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December 2018

Catheter Tract Metastasis in Mesothelioma Patients with Indwelling Pleural Catheters: A Retrospective Cohort Study.

Respiration 2018 Dec 13:1-8. Epub 2018 Dec 13.

Division of Respirology, Department of Medicine, University of Ottawa, Ottawa, Ontario,

Background: Use of indwelling pleural catheters (IPCs) for the management of symptomatic pleural effusions in patients with mesothelioma has increased in popularity. An important concern with this approach is the potential for the development of catheter tract metastasis (CTM).

Objectives: To determine the incidence of IPC-related CTM in patients with malignant pleural mesothelioma (MPM). Read More

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December 2018
1 Read

Safety of Pleuroscopy Performed in Negative Pressure Bronchoscopy Rooms.

J Bronchology Interv Pulmonol 2018 Dec 12. Epub 2018 Dec 12.

Departments of Pulmonary Medicine.

Background: The use of pleuroscopy has expanded over the last decade due to its higher diagnostic yield and low complications rate. Whether the infectious complications of pleuroscopy performed in negative pressure rooms is similar to that of pleuroscopy performed in positive pressure rooms remain unclear. To assess the safety of pleuroscopy performed in negative pressure rooms, we sought to determine the rate of infectious complications in patients who underwent pleuroscopy in negative pressure bronchoscopy rooms at our institution. Read More

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December 2018

Computed tomography and pathology evaluation of lung ground-glass opacity.

Exp Ther Med 2018 Dec 22;16(6):5305-5309. Epub 2018 Oct 22.

Department of Radiology, Affiliated Hospital of Qingdao University, Qingdao, Shandong 266101, P.R. China.

The aim of this study was to investigate the pathogenesis of lung ground-glass opacity (GGO) and the diagnostic value of computed tomography scan for lung GGO. Computed tomography (CT) images of 106 lung GGO cases were analyzed retrospectively, and the type, location, size, structure, boundaries and surrounding lung fields were evaluated. There were 12 cases of GGO with a diameter <1. Read More

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December 2018

Diagnostic value of medical thoracoscopy for undiagnosed pleural effusions.

Exp Ther Med 2018 Dec 17;16(6):4590-4594. Epub 2018 Sep 17.

Department of Respiratory Medicine, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi 710068, P.R. China.

To investigate the diagnostic value of medical thoracoscopy for the diagnosis of undiagnosed pleural effusions, a retrospective study was performed on the clinical data of 86 patients with undiagnosed pleural effusions who had medical thoracoscopy at Shaanxi Provincial People's Hospital (Xi'an, China) between May 2012 and November 2013. Of the 86 patients, 79 cases of pleural effusions were confirmed by medical thoracoscopic biopsy with a diagnosis rate of 91.9%. Read More

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December 2018

Comparative study of primary pulmonary cryptococcosis with multiple nodules or masses by CT and pathology.

Exp Ther Med 2018 Dec 17;16(6):4437-4444. Epub 2018 Sep 17.

Department of Respiratory Disease, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, P.R. China.

The manifestations of pulmonary cryptococcosis with multiple nodules or masses on computed tomography (CT) are diverse and difficult to differentiate from those of lung cancer and pulmonary tuberculosis. The present study compared the multislice spiral CT signs with pathological results and used the pathological results to explain the CT signs with the aim of improving the accuracy of the diagnosis of this disease. A retrospective analysis of 20 patients with primary pulmonary cryptococcosis with multiple nodules or masses was performed. Read More

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December 2018

Pleural effusion as an initial manifestation in a patient with primary pulmonary monoclonal B-cell lymphocyte proliferative disease.

Respir Res 2018 Dec 12;19(1):247. Epub 2018 Dec 12.

Department of Neurology, West China Hospital, Sichuan University, Guo Xuexiang #37, Chengdu, 610041, China.

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December 2018

The diagnostic role of pentraxin-3 in the differential diagnosis of pleural effusions

Turk J Med Sci 2018 12 12;48(6):1167-1174. Epub 2018 Dec 12.

Department of Chest Disease, School of Medicine, Ankara University, Ankara, Turkey

Background/aim: Discrimination of pleural effusion etiology is not always easy in clinical practice. Pentraxin-3 (PTX-3) is a new acute- phase protein. The aim of this study was to investigate the role of PTX-3 in the differential diagnosis of pleural effusions. Read More

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December 2018

Low-dose cyclophosphamide depletes circulating naïve and activated regulatory T cells in malignant pleural mesothelioma patients synergistically treated with dendritic cell-based immunotherapy.

Oncoimmunology 2018 30;7(12):e1474318. Epub 2018 Jul 30.

Department of Pulmonary Medicine, Erasmus MC, Rotterdam, The Netherlands.

: Regulatory T cells (Treg) play a pivotal role in the immunosuppressive tumor micro-environment in cancer, including mesothelioma. Recently, the combination of autologous tumor lysate-pulsed dendritic cells (DC) and metronomic cyclophosphamide (mCTX) was reported as a feasible and well-tolerated treatment in malignant pleural mesothelioma patients and further as a method to reduce circulating Tregs. : The aim of this study was to establish the immunological effects of mCTX alone and in combination with DC-based immunotherapy on circulating Treg and other T cell subsets in mesothelioma patients. Read More

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July 2018
6.283 Impact Factor

A single centre phase II trial to assess the immunological activity of TroVax® plus pemetrexed/cisplatin in patients with malignant pleural mesothelioma - the SKOPOS trial.

Oncoimmunology 2018 7;7(12):e1457597. Epub 2018 Sep 7.

Wales Cancer Trials Unit, Centre for Trials Research, Cardiff University, Cardiff, UK.

Vaccines in combination with chemotherapy have been shown to be safe in different tumor types. We investigated the immunological activity of the TroVax® vaccine in combination with pemetrexed-cisplatin chemotherapy in malignant pleural mesothelioma (MPM). In this first line, open-label, single-arm, phase 2 study, patients with locally advanced or metastatic MPM were enrolled. Read More

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September 2018

Comparative evaluation of ultrasonography with clinical respiratory score in diagnosis and prognosis of respiratory diseases in weaned dairy buffalo and cattle calves.

J Anim Sci Technol 2018 3;60:29. Epub 2018 Dec 3.

2Klinik für Klauentiere, Freie Universität Berlin, 14163 Berlin, Germany.

Background: Respiratory troubles have economic impacts in countries where livestock industry is an important segment of the agricultural sector, as well as these problems may cause significant economic losses for bovine producers. Various practical methods are used to assess diseases that affect the bovine respiratory system. Ultrasonography is a noninvasive tool that has been used frequently in diagnosis of various animal diseases. Read More

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December 2018

Cytotoxic Natural Killer Subpopulations as a Prognostic Factor of Malignant Pleural Effusion.

Lung 2018 Dec 6. Epub 2018 Dec 6.

Unit of Public Health and Environmental Care, Department of Preventive Medicine, University of Valencia, Valencia, Spain.

Background: Malignant pleural effusion (MPE) is a sign of advanced disease of poor prognosis. As natural killer (NK) cells are involved in the first line of tumour defence, we aimed to validate a new diagnostic and prognostic indicator for MPE based on NK subpopulations of pleural fluid (PF) and peripheral blood (PB).

Methods: NK subpopulations were determined in PF and PB in 71 patients with malignant, paramalignant or benign pleural effusion. Read More

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December 2018
1 Read

Improving the management of spontaneous pneumothorax.

Authors:
José M Porcel

Eur Respir J 2018 Dec 6;52(6). Epub 2018 Dec 6.

Pleural Medicine Unit, Dept of Internal Medicine, Arnau de Vilanova University Hospital, IRBLleida, Lleida, Spain

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December 2018

Tunneled Pleural Catheter: Treatment for Recurrent Pleural Effusion.

AACN Adv Crit Care 2018 ;29(4):432-441

Chelsea Miller is Advanced Practice Provider Clinical Resident, Emory Healthcare, 1364 Clifton Road, Atlanta, GA 30322 Elizabeth Bridges is Professor, University of Washington School of Nursing, Seattle, Washington. Balaji Laxmanan is Director, Interventional Pulmonology, Confluence Health, Wenatchee, Washington. Paula Cox-North is Lecturer, University of Washington School of Nursing, Department of Biobehavioral Nursing and Health Informatics, Seattle, Washington. Hilaire Thompson is Joanne Montgomery Endowed Professor and Lead, Adult/Gerontology Acute Care Nurse Practitioner Program, University of Washington School of Nursing, Seattle, Washington.

Recurrent pleural effusion is a symptom of several end-stage diseases and is associated with limited life expectancy. Patients with this condition have disabling symptoms resulting in reduced quality of life and often receive inconsistent treatment due to delayed recognition of pleural effusion, repeat procedures, and lengthy hospitalizations. Placement of a tunneled pleural catheter allows the patient to manage his or her symptoms at home, yet this treatment remains underused because of provider misconceptions and unfamiliarity with the intervention. Read More

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January 2018

The clinical utility of cycle of threshold value of GeneXpert MTB/RIF (CBNAAT) and its diagnostic accuracy in pulmonary and extra-pulmonary samples at a tertiary care center in India.

Indian J Tuberc 2018 Oct 8;65(4):296-302. Epub 2018 Jun 8.

Department of Respiratory & Sleep Medicine, Medanta - The Medicity Gurgaon, India.

Background: There are knowledge gaps in the in-depth analysis of the most promising and robust diagnostic tool, GeneXpert MTB/RIF (CBNAAT). The cycle of threshold (CT) value of the CBNAAT test and its clinical implications has not been explored much.

Aims And Objectives: The study aimed at (a) estimating the diagnostic accuracy and incremental yield of Xpert MTB/RIF in various specimens (b) establishing the association between CT value category (high, medium, low, very low) and culture time-to-positivity (TTP). Read More

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October 2018

Solitary Fibrous Tumor: A Giant Pleural Mass.

Mayo Clin Proc 2018 Dec;93(12):1881-1882

Division of Pulmonary Medicine, St Agnes Hospital, Baltimore, MD. Electronic address:

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December 2018

Elevated Hsp90-beta contributes to differential diagnosis of pleural effusion caused by lung cancer and correlates with malignant biological behavior of lung cancer.

BMC Pulm Med 2018 Dec 6;18(1):188. Epub 2018 Dec 6.

Department of Respiratory Medicine, Gansu Provincial Hospital, Lanzhou, China.

Background: Hsp90-beta has been investigated to be correlated with the occurrence and development of tumor. The intention of this research was to test the level of Hsp90-beta in malignant pleural effusion (MPE) of patients with lung cancer and disclose the clinical significance of Hsp90-beta as a potential tumor marker for differential diagnosis of pleural effusion caused by lung cancer.

Methods: The level of Hsp90-beta was determined using enzyme-linked immunosorbent assay. Read More

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December 2018

[Spontaneous haemothorax - thoracic surgeon and intervention radiologist successful cooperation].

Magy Seb 2018 Dec;71(4):155-162

Mellkassebészeti Részleg, Mellkas- és Érsebészeti Osztály, Borsod-Abaúj-Zemplén Megyei Központi Kórház és Egyetemi Oktatókórház 3526, Miskolc, Szentpéteri kapu 72-76.

The definition of spontaneous haemothorax is accumulation of blood within the pleural space without trauma or iatrogenic causes. A case of a 17-year-old male patient with a history of multiple abnormal arterial fistulas between systemic circulation and pulmonary circulation as a cause of bleeding is presented. An overview of the causes, the clinical features of haemothorax and the interventional radiological methods that can solve some causes of haemothorax are presented in connection of our case report. Read More

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December 2018

Does Ipsilateral-Dependent Positioning During Percutaneous Lung Biopsy Decrease the Risk of Pneumothorax?

AJR Am J Roentgenol 2018 Dec 12:1-6. Epub 2018 Dec 12.

1 Department of Radiology, Cochin Hospital, Descartes University, 27 rue du Faubourg Saint Jacques, 75 014 Paris, France.

Objective: The purpose of this study is to determine whether placing patients in an ipsilateral-dependent position during percutaneous CT-guided transthoracic biopsy reduces the pneumothorax rate.

Materials And Methods: Between July 2013 and August 2017, a total of 516 patients (317 men and 199 women; mean age, 66.4 years) underwent core needle biopsies performed using 17- and 18-gauge needles. Read More

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December 2018

Procurement and Storage of Pleural and Peritoneal Fluids for Biobanking.

Methods Mol Biol 2019 ;1897:125-133

Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA, USA.

There is limited information regarding the biobanking of pleural and peritoneal fluids that might supplement storage of pulmonary and thoracic tissue biospecimens. Such fluids are sometimes collected for clinical analyses and may have uses that obviate or supplement tissue samples. There has been a growing interest in using liquid biopsies as they are less invasive and may be amenable to analyses that guide targeted therapies. Read More

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January 2019

The FAK inhibitor BI 853520 inhibits spheroid formation and orthotopic tumor growth in malignant pleural mesothelioma.

J Mol Med (Berl) 2018 Dec 11. Epub 2018 Dec 11.

Division of Thoracic Surgery, Department of Surgery, Comprehensive Cancer Center, Medical University of Vienna, Waehringer Guertel 18-20, A-1090, Vienna, Austria.

No tyrosine kinase inhibitors are approved for malignant pleural mesothelioma (MPM). Preclinical studies identified focal adhesion kinase (FAK) as a target in MPM. Accordingly, we assessed the novel, highly selective FAK inhibitor (BI 853520) in 2D and 3D cultures and in vivo. Read More

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December 2018

Digital pathology is a practical alternative to on-site intra-operative frozen section diagnosis in thoracic surgery.

Histopathology 2018 Dec 11. Epub 2018 Dec 11.

Thoracic Surgery, Bristol Royal Infirmary, University Hospitals Bristol NHS Foundation Trust, Bristol, United Kingdom.

Introduction: Telepathology uses digitised image transfer to allow off-site reporting of histopathology slides. This technology could facilitate the centralisation of pathology services, which may improve their quality and cost-effectiveness. The benefits may be most apparent in frozen section reporting, where turnaround times are vital. Read More

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December 2018

Empyema: A debilitating condition that warrants further research.

Authors:
Pyng Lee

Respirology 2018 Dec 11. Epub 2018 Dec 11.

Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

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December 2018

Computed tomography pulmonary angiography and venography with a low dose of contrast medium.

Radiol Phys Technol 2018 Dec 10. Epub 2018 Dec 10.

Department of Radiology, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe, Saitama, 350-8550, Japan.

The authors developed a method to ensure sufficient opacification of pulmonary vasculature for separate depiction of arteries and veins in three-dimensional form with a small dose of contrast medium utilizing a test injection to determine optimal timing of computed tomography (CT) scanning. The dose was determined by a simulation based on a pharmacokinetic model. The contrast medium was administered at a rate of 5. Read More

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December 2018

Combined modality treatment for malignant pleural mesothelioma: a single-centre long-term survival analysis using extrapleural pneumonectomy.

Eur J Cardiothorac Surg 2018 Dec 6. Epub 2018 Dec 6.

Department of Thoracic Surgery, University Hospitals KU Leuven, Leuven, Belgium.

Objectives: Combined modality treatment (CMT) for malignant pleural mesothelioma (MPM) remains a matter of debate regarding the choice of surgical procedure: extrapleural pneumonectomy (EPP) or pleurectomy/decortication.

Methods: We performed a prospective interventional cohort study between 2003 and 2014. All consecutive patients with any histological MPM subtype, ≤70 years old, World Health Organization performance status ≤1, medically fit for pneumonectomy and stage cT1-2cN0-2cM0 (TNM7) or lower were included. Read More

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December 2018

A symptomatic anterior mediastinal mass with a simultaneous infection.

Respirol Case Rep 2019 Feb 4;7(2):e00394. Epub 2018 Dec 4.

Division of Thoracic Surgery, Department of Surgery Taipei Veterans General Hospital Taipei Taiwan.

Surgical resection remains the treatment of choice for mature mediastinal teratoma, and the operation itself is sometimes complicated or life-threatening, especially when it ruptures into adjacent vital structures. We describe a rare case of unanticipatedly delayed complete resection of a symptomatic teratoma with simultaneous infection, followed by extended rupture into the pleural space, lung, and bronchus. The clinical presentation and the microbiological and radiologic features may lead to the impression of a lung abscess until it can be proven otherwise pathologically after an initial thoracic aspiration. Read More

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February 2019
1 Read

Computer Aided Diagnosis System for Detection of Cancer Cells on Cytological Pleural Effusion Images.

Biomed Res Int 2018 8;2018:6456724. Epub 2018 Nov 8.

Department of Pathology, Faculty of Medicine, Srinakharinwirot University, Nakhon Nayok, Thailand.

Cytological screening plays a vital role in the diagnosis of cancer from the microscope slides of pleural effusion specimens. However, this manual screening method is subjective and time-intensive and it suffers from inter- and intra-observer variations. In this study, we propose a novel Computer Aided Diagnosis (CAD) system for the detection of cancer cells in cytological pleural effusion (CPE) images. Read More

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November 2018
1 Read

Simultaneous presence of lung adenocarcinoma and malignant pleural mesothelioma: A case report.

Respir Med Case Rep 2019 19;26:45-49. Epub 2018 Nov 19.

Department of Pathology, Kobe City Medical Center West Hospital, Japan.

The co-presence of malignant pleural mesothelioma (MPM) and lung cancer is rare. We report a 70-year-old male with exposure to asbestos. Chest computed tomography revealed a right mediastinal mass combined with an enlarged ipsilateral lymph node and left pleural effusion. Read More

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November 2018

Thoracic spine dislocation in Gorham-Stout Syndrome: Case report and literature review.

Surg Neurol Int 2018 1;9:223. Epub 2018 Nov 1.

Spanish Hospital, Mendoza, Argentina.

Background: The Gorham-Stout syndrome (GSS), also known as phantom bone disease, is a rare bone condition of unknown etiology. Involvement of the spine is described in <50 cases in the literature. Here, we report a case of thoracic spine fracture dislocation in a young female who was known to have GSS. Read More

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November 2018

[Fast-track rehabilitation after anatomical lung resection: prospective single-center non-randomized trial].

Khirurgiia (Mosk) 2018 (11):5-10

Vishnevsky Institute of Surgery of Healthcare Ministry of Russia, Moscow, Russia.

Aim: To present the results of fast track rehabilitation after anatomical lung resection.

Material And Methods: Single-center prospective non-randomized trial has included patients for the period December 2014 - December 2016. Conventional protocol was applied in 124 patients, 58 patients after atypical lung resections or pneumonectomy were excluded from the study. Read More

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January 2018

[Thrombotic microangiopathy developing subsequent to tocilizumab therapy in a patient with TAFRO syndrome].

Rinsho Ketsueki 2018 ;59(11):2432-2437

Department of Pathology, Hakodate Municipal Hospital.

We report a case of a 60-year-old male who presented with fever and anasarca as well as hepatosplenomegaly, general lymphadenopathy, and disseminated intravascular coagulation (DIC), and was, therefore, admitted to our hospital. In addition, the patient suffered from respiratory failure and renal dysfunction and had pleural effusion and ascites. The pathological diagnosis from lymph node biopsy suggested multicentric Castleman's disease of the plasma cell type; however, the presence of high IL-6 levels, myelofibrosis, thrombocytopenia, anasarca, renal dysfunction, and hepatosplenomegaly led to a definitive diagnosis of TAFRO syndrome. Read More

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January 2018

The association between computed tomography scan findings of pulmonary infection caused by atypical mycobacteria and bacillus count in sputum samples.

Int J Mycobacteriol 2018 Oct-Dec;7(4):355-357

Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Disease, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: The use of imaging techniques is important for prompt diagnosis and treatment of atypical mycobacterial infections; it also reduces the burden of these infections. The purpose of the present study was to determine the association between computed tomography (CT) scan findings of pulmonary infection caused by atypical mycobacteria and bacillus count in sputum samples.

Methods: This cross-sectional, observational, comparative study included 50 consecutive patients with pulmonary infection caused by atypical mycobacteria, who were hospitalized in Masih-Daneshvari Hospital of Tehran, Iran during 2012-2017. Read More

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December 2018

Clustering of malignant pleural mesothelioma in asbestos factories: a subgroup analysis in a 29-year follow-up study to identify high-risk industries in Taiwan.

BMJ Open 2018 Dec 9;8(12):e021063. Epub 2018 Dec 9.

Department of Public Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Objective: Exposure to asbestos is the major cause for malignant pleural mesothelioma (MPM), but the causal link of individual cases is difficult to establish for lack of exposure information and long disease latency.

Methods: We established a retrospective cohort of workers employed in asbestos industries during the period of 1950-1989 and the occurrence of MPM during the period of 1980-2009 was examined with the Taiwan Cancer Registry. Estimated rate ratios (eRRs) were computed for each factory where any case of MPM was diagnosed by assuming Poisson distribution with a minimal latency of 20 years. Read More

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December 2018
1 Read

Minimally Invasive Surgery for Resection of Diaphragm Metastases in Ovarian Cancer.

J Minim Invasive Gynecol 2018 Dec 7. Epub 2018 Dec 7.

Department of Surgical Gynecology, Mayo Clinic Hospital, Phoenix, Arizona.

Study Objective: To estimate pulmonary complications and diaphragm recurrence after resection of diaphragm metastases by minimally invasive surgery (MIS) for epithelial ovarian cancer (EOC).

Design: Retrospective analysis.

Design Classification: III. Read More

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December 2018
1 Read

Should thoracentesis be performed to diagnose pleural effusion of cardiac origin?

Arch Bronconeumol 2018 Dec 7. Epub 2018 Dec 7.

Servicio de Neumología, Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, La Coruña, España; Grupo Interdisciplinar de Investigación en Neumología, Instituto de Investigaciones Sanitarias de Santiago (IDIS), Santiago de Compostela, La Coruña, España.

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December 2018

To slay a dragon: Timing of chemotherapy in resectable pleural mesothelioma.

J Thorac Cardiovasc Surg 2018 Nov 2. Epub 2018 Nov 2.

Division of General Thoracic Surgery, The Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Tex.

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November 2018

CT-guided Transthoracic Core-Needle Biopsies of Mediastinal and Lung Lesions in 235 Consecutive Patients: Factors Affecting the Risks of Complications and Occurrence of a Final Diagnosis of Malignancy.

Arch Bronconeumol 2018 Dec 4. Epub 2018 Dec 4.

Hospital de Base, Faculdade de Medicina de São José do Rio Preto, São Paulo, Brazil.

Objective: To assess the impact of patient-, lesion- and procedure-related factors on the risks of complications and final diagnosis of malignancy in PCNB of mediastinal and lung lesions.

Material And Methods: We studied a large single-center cohort of 235 consecutive patients (66.8% men; 58. Read More

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December 2018

Should thoracentesis be performed to diagnose pleural effusion of cardiac origin?

Arch Bronconeumol 2018 Dec 4. Epub 2018 Dec 4.

Servicio de Neumología, Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, La Coruña, España; Grupo Interdisciplinar de Investigación en Neumología, Instituto de Investigaciones Sanitarias de Santiago (IDIS), Santiago de Compostela, La Coruña, España.

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December 2018

Radiomics Signature: A Biomarker for the Preoperative Distant Metastatic Prediction of Stage I Nonsmall Cell Lung Cancer.

Acad Radiol 2018 Dec 5. Epub 2018 Dec 5.

Department of Radiology, Changzheng Hospital, Second Military Medical University, No. 415 Fengyang Road, Shanghai 200233, China. Electronic address:

Objectives: To evaluate the predictive value of radiomics features on the distant metastasis (DM) of stage I nonsmall cell lung cancer (NSCLC) preoperatively, by comparing with clinical characteristics and CT morphological features, and to screen the important prognostic predictors.

Methods: One hundred ninety-four stage I NSCLC patients were retrospectively enrolled, DM free survival (DMFS) was evaluated. The consensus clustering analysis was used to build the radiomics signatures in the primary cohort and validated in the validation cohort. Read More

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December 2018

Assessment of signaling pathway inhibitors and identification of predictive biomarkers in malignant pleural mesothelioma.

Lung Cancer 2018 Dec 16;126:15-24. Epub 2018 Oct 16.

Inserm, UMR-1162, Génomique fonctionnelle des tumeurs solides, F-75010, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Labex Immuno-oncology, F-75000, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, Paris, F-75010, France; Université Paris 13, Sorbonne Paris Cité, F-93206, Saint-Denis, France. Electronic address:

Objectives: Malignant pleural mesothelioma (MPM) is an aggressive tumor with limited therapeutic options, requiring the development of efficient targeted therapies based on molecular phenotype of the tumor and to identify predictive biomarkers of the response.

Materials And Methods: The effect of inhibitors was investigated by cell viability assessment on primary MPM cell lines established in our laboratory from patient tumors, well characterized at the molecular level. Effects on apoptosis, cell proliferation and viability on MPM growing in multicellular spheroid were also assessed for verteporfin. Read More

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December 2018
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New insights into the impact of primary lung adenocarcinoma location on metastatic sites and sequence: A multicenter cohort study.

Lung Cancer 2018 Dec 5;126:139-148. Epub 2018 Nov 5.

National Korányi Institute of Pulmonology, Budapest, Hungary. Electronic address:

Introduction: The presence of organ metastases is a major factor for unfavorable prognosis in lung adenocarcinoma (LADC). However, the influence of primary tumor location on metastatic sites and sequence has not been extensively analyzed.

Methods: We performed a multicenter cohort study, evaluating clinicopathological data of 1126 Caucasian LADC patients, focusing on the distinct location of primary tumors and metastatic sites during disease progression. Read More

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December 2018

Liquid biopsy using the supernatant of a pleural effusion for EGFR genotyping in pulmonary adenocarcinoma patients: a comparison between cell-free DNA and extracellular vesicle-derived DNA.

BMC Cancer 2018 Dec 10;18(1):1236. Epub 2018 Dec 10.

Department of Pulmonary, Lung Cancer Center, Konkuk University Medical Center and Medicine, Konkuk University School of Medicine, 120-1 Hwayang-dong, Gwangjin-Gu, Seoul, 05030, Republic of Korea.

Background: EGFR genotyping in pulmonary adenocarcinoma patients who develop pleural effusions is mostly performed using cytology or cell block slides with low sensitivity. Liquid biopsy using the supernatant of pleural effusions may be more effective because they contain many components released by cancer cells. Extracellular vesicles (EVs) are known to carry oncogenic double-stranded DNA that is considered a notable biomarker. Read More

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December 2018