15,616 results match your criteria Pleomorphic Parotid Adenoma Imaging


Histological Subtypes and Clinical Behavior Evaluation of Salivary Gland Tumors.

Acta Med Port 2018 Nov 30;31(11):641-647. Epub 2018 Nov 30.

Department of Pathology. Centro Hospitalar São João. Porto. Unit of Pathology and Oncology. Department of Pathology. Faculdade de Medicina. Universidade do Porto. Porto. Portugal.

Introduction: Salivary gland tumors include a wide spectrum of histological subtypes and clinical behavior, which we aim to evaluate.

Material And Methods: We performed a retrospective study of all salivary gland tumors diagnosed and treated at the Centro Hospitalar São João, Porto, between 2005 and 2015. Histological re- evaluation was performed in all cases and patient files were reviewed and both clinical and follow-up data were collected. Read More

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November 2018
3 Reads

ERBB2 mutation frequency in lobular breast cancer with pleomorphic histology or high-risk characteristics by molecular expression profiling.

Genes Chromosomes Cancer 2018 Dec 5. Epub 2018 Dec 5.

Institute of Pathology, Hannover Medical School, Hannover, Germany.

HER2-positive breast cancer is defined by amplification or overexpression of the HER2/ERBB2 oncogene and accounts for about 15% of breast cancer (BC) cases. Somatic mutation of ERBB2 is an alternative mechanism, by which activation of HER2 signaling can occur. ERBB2 mutation has been associated with invasive lobular breast cancer (ILBC). Read More

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December 2018
1 Read

Intraparotid Facial Nerve Schwannoma in a Nine-Year-Old Patient: Diagnosis, Classification, and Surgical Approach Stages.

J Craniofac Surg 2018 Nov 30. Epub 2018 Nov 30.

Department of Pathology, The Ministry of Health Izmir Tepecik Training and Research Hospital, Izmir, Turkey.

Intraparotid facial nerve schwannoma (IFNS) is rarely observed in children compared with adults. Only a few cases have been reported in the literature. After radiological imaging and fine needle aspiration biopsy, an IFNS diagnosis may be skipped and confused with pleomorphic adenoma, which has a high prevalence among patients who have a mass in the parotid gland. Read More

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November 2018

Primary cutaneous CD4+ small/medium pleomorphic T-cell lymphoproliferative disorder: Where do we stand? A systematic review.

Authors:
Eman Salah

J Dtsch Dermatol Ges 2018 Dec 3. Epub 2018 Dec 3.

Department of Dermatology, Venereology & Andrology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Primary cutaneous CD4+ small/medium pleomorphic T-cell lymphoproliferative disorder (PCSMP-TLPD) is a provisional entity with uncertain malignant potential according to the latest revision of the WHO classification for lymphoid neoplasms. We conducted a systematic literature review of all previously reported cases of PCSMP-TLPD to highlight their typical and atypical features. The main features of PCSMP-TLPD and its possible clinicopathologic overlap with similar disorders are also discussed. Read More

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December 2018
1 Read

Deciduoid type malignant pleural mesothelioma: a case report.

AME Case Rep 2018 4;2:43. Epub 2018 Oct 4.

Department of General Thoracic Surgery, Kawasaki Medical School, Kurashiki, Japan.

Here, we report a patient with deciduoid type malignant pleural mesothelioma (MPM), which rapidly progressed. A 55-year-old man who might have been exposed to asbestos a few decades ago had severe back pain. The chest X-ray scanning and computed tomography (CT) revealed pleural thickness on his right thoracic space, without the presence of a lung mass. Read More

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October 2018

Neuroimmune and Inflammatory Signals in Complex Disorders of the Central Nervous System.

Neuroimmunomodulation 2018 Dec 5:1-25. Epub 2018 Dec 5.

Neuroscience Program, Federal Fluminense University, Niterói, Brazil.

An extensive microglial-astrocyte-monocyte-neuronal cross talk seems to be crucial for normal brain function, development, and recovery. However, under certain conditions neuroinflammatory interactions between brain cells and neuroimmune cells influence disease outcome and brain pathology. Microglial cells express a range of functional states with dynamically pleomorphic profiles from a surveilling status of synaptic transmission to an active player in major events of development such as synaptic elimination, regeneration, and repair. Read More

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December 2018
3 Reads

Spinal Pleomorphic Xanthoastrocytoma With a QKI-RAF1 Fusion.

J Neuropathol Exp Neurol 2018 Dec 5. Epub 2018 Dec 5.

Department of Pathology.

Pleomorphic xanthoastrocytoma (PXA) is a slow-growing neoplasm that predominantly affects the pediatric and young adult population. This neoplasm has a good prognosis, with a median 10-year survival rate of 70%. The majority of tumors are supratentorial and arise in the temporal lobe, while spinal tumors are extremely rare, with only 8 reported cases. Read More

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December 2018
5 Reads

A rare ectopic localization of pleomorphic adenoma.

J Stomatol Oral Maxillofac Surg 2018 Dec 1. Epub 2018 Dec 1.

Department of Oral & ENT Pathology, Pitié-Salpêtrière Hospital, Department of Dermatology, Cochin-Port Royal Hospital, Paris France.

Introduction: Pleomorphic adenoma (PA) is the most common benign salivary gland tumor, frequently affecting the major salivary glands but also the palatal or labial minor salivary glands. Pleomorphic adenomas affecting the retromolar trigone have seldom been reported with only few cases described in the literature.

Observation: We present the case of a young female patient who presented with this rare localization of pleomorphic adenoma and its subsequent management. Read More

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December 2018
1 Read

Diagnosis of an extremely rare pleomorphic adenoma of the breast with core needle biopsy: A case report.

Ann Med Surg (Lond) 2018 Dec 5;36:242-245. Epub 2018 Nov 5.

Takahashi Breast and Gastroenterology Clinic, Yamazaki Seiren Bldg. 2F, 6-2-22, Uehonmachi, Tennoji-Ku, 543-0001, Osaka, Japan.

Introduction: Pleomorphic adenoma (PA) rarely originates in the mammary gland. This tumor is a benign mixed tumor and is commonly found in the salivary glands, but rarely shows findings similar to those of breast cancer. The tumor is misdiagnosed in 30-50% of the patients, including overdiagnosis of malignancy preoperatively, leading to unnecessary surgery for breast cancer. Read More

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December 2018

Parotid Lymphoepithelial Cyst in a HIV-Negative Individual: A Case Report.

Iran J Med Sci 2018 Nov;43(6):668-670

Department of General Surgery, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India.

Benign lymphoepithelial cysts of the parotid are common in retropositive patients, but extremely rare in HIV-negative individuals. We present a 28-year-old man who presented with a painless, gradually increasing swelling in the left parotid region and was clinically diagnosed to have a pleomorphic adenoma of the left parotid gland. Preoperative blood investigations revealed that the patient was seronegative. Read More

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November 2018

A comparison of conventional and diffusion-weighted magnetic resonance imaging in the diagnosis of sialadenitis and pleomorphic adenoma.

Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Oct 18. Epub 2018 Oct 18.

Department of Stomatology, School of Dentistry, University of Sao Paulo, Sao Paulo, Brazil.

Objectives: The aim of this study was to compare the efficacy of conventional magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI) in correctly identifying the presence of disease in the major salivary glands and correctly distinguish sialadenitis from pleomorphic adenoma.

Study Design: Twenty-one patients diagnosed with unilateral sialadenitis or pleomorphic adenoma were selected. The nonaffected contralateral glands were also analyzed. Read More

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October 2018

Outcomes of pleomorphic lobular carcinoma versus invasive lobular carcinoma.

Breast 2018 Nov 21;43:67-73. Epub 2018 Nov 21.

Department of Radiation Oncology, Houston Methodist Hospital, Houston, TX, USA. Electronic address:

Purpose: Pleomorphic lobular carcinoma (PLC) is a rare histologic variant of invasive lobular carcinoma (ILC) that has been associated with worse clinical outcomes than classic ILC. Owing to its rarity, high-volume studies of its clinical characteristics and prognosis are lacking. The purpose of this study was to use a large, contemporary cancer database to investigate the clinical characteristics and survival outcomes for patients with PLC. Read More

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November 2018
1 Read

Molecular features of pleomorphic xanthoastrocytoma.

Hum Pathol 2018 Nov 26. Epub 2018 Nov 26.

Department of Pathology, Xiangya Hospital, Central South University, Changsha, China; Department of Pathology, Xiangya Medical School, Central South University, Changsha; Department of Pathology, Institute of Basic Medicine, Xinjiang Medical University, Urumqi, China. Electronic address:

Pleomorphic xanthoastrocytoma (PXA) is a rare central nervous system tumor occurring mostly in children and young adults. Next-generation sequencing of 295 cancer-related genes was used to investigate the molecular profiles of 13 cases of PXA. We found that BRAF V600E (5/13; 38%), FANCA/D2/I/M (5/13; 38%), PRKDC (4/13; 31%), NF1 (3/13; 23%), and NOTCH2/3/4 (3/13; 23%) alterations were the most frequent somatic gene mutations. Read More

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November 2018
2 Reads

Pleomorphic and Florid Lobular Carcinoma in Situ Variants of the Breast: A Clinicopathologic Study of 85 Cases With and Without Invasive Carcinoma From a Single Academic Center.

Am J Surg Pathol 2018 Nov 27. Epub 2018 Nov 27.

Department of Pathology, University of California San Francisco, San Francisco, CA.

The natural history and optimal treatment of pleomorphic (PLCIS) and florid (FLCIS) lobular carcinoma in situ variants remains uncertain. We reviewed the clinicopathologic features and management of LCIS variants at our institution over a 20-year period. Of 85 cases (61 PLCIS, 24 FLCIS), 77% were associated with invasive carcinoma (84% lobular, 13% ductal/lobular, 3% ductal) and only 17% (9 PLCIS, 5 FLCIS) were pure. Read More

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November 2018

Fractionated radiotherapy might induce epithelial-mesenchymal transition and radioresistance in a cellular context manner.

J Cell Biochem 2018 Nov 28. Epub 2018 Nov 28.

Department of Medical Physics, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Despite the fact that radiotherapy is a main therapeutic modality in cancer treatment, recent evidence suggests that fractionated radiotherapy (FR) might confer radioresistance through epithelial-mesenchymal transition (EMT). Nevertheless, the effects of FR on EMT phenotype and the potential link between EMT induction and radioresistance development yet to be clarified. The aim of this study was to assess whether FR could promote EMT, and to elucidate if induction of EMT contributes to the acquisition of radioresistance. Read More

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November 2018

Non-contrast computed tomography and magnetic resonance imaging features of mucoepidermoid carcinoma in the salivary glands.

Oral Radiol 2018 Jan 27;34(1):24-30. Epub 2017 Mar 27.

Department of Oral Radiology, Osaka Dental University, 1-5-17, Otemae, Chuo-ku, Osaka, 540-0008, Japan.

Background: Use of contrast-enhanced cross-sectional imaging is considered standard practice for investigating mucoepidermoid carcinoma (MEC) in the salivary glands. The purpose of this study was to present the common features of MEC on computed tomography (CT) and magnetic resonance imaging (MRI) without contrast enhancements, and to investigate the possibility of discriminating between MEC and pleomorphic adenoma based on the features observed on both modalities.

Methods: Twenty cases of biopsy-confirmed MEC originating in the salivary glands were reviewed and characterized by two oral and maxillofacial radiologists with regard to the following aspects: detectability, margin, border, encapsulation, content, contrast between lesion and masticator muscle, and bone changes. Read More

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January 2018

Acantholytic Squamous Cell Carcinoma and Salivary Duct Carcinoma Ex-pleomorphic Adenoma of the Submandibular Gland: A Report of Two Extremely Rare Cases with an Immunohistochemical Analysis.

Head Neck Pathol 2018 Nov 27. Epub 2018 Nov 27.

Pathology Division, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka, 411-8777, Japan.

Carcinoma ex pleomorphic adenoma (CXPA) is a malignant tumor of the salivary gland that arises from pleomorphic adenoma (PA). Squamous cell carcinoma (SCC) is extremely rare in the salivary glands. We report two cases of acantholytic SCC (ASCC) ex PA. Read More

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November 2018
1 Read

Diffusion-weighted magnetic resonance imaging in oral and maxillofacial lesions: preliminary study on diagnostic ability of apparent diffusion coefficient maps.

Oral Radiol 2018 Sep 4;34(3):224-228. Epub 2017 Sep 4.

Department of Radiology, The Nippon Dental University Niigata Hospital, 1-8 Hamaura-cho, Chuo-ku, Niigata, Niigata, 951-8580, Japan.

Objectives: The aim of this study was to investigate the usefulness of diffusion-weighted magnetic resonance imaging (DWI) in oral and maxillofacial lesions, especially the utility of apparent diffusion coefficient (ADC) maps for differential diagnosis of these lesions.

Methods: Fifty-seven patients who underwent magnetic resonance imaging for diagnosis of oral and maxillofacial lesions were included in this prospective study. DWI was performed on a 1. Read More

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September 2018

Roseovarius ponticola sp. nov., a novel lipolytic bacterium of the family Rhodobacteraceae isolated from seawater.

Arch Microbiol 2018 Nov 27. Epub 2018 Nov 27.

Department of Food Science and Biotechnology, Sungkyunkwan University, Jangan-gu, Suwon, South Korea.

A lipolytic, Gram-negative, aerobic, non-motile and pleomorphic bacterial strain, designated W-SW3, was isolated from seawater around Wando, an island of South Korea, and its taxonomic position was determined using a polyphasic approach. Its optimal growth occurred at 30 °C, pH 7.0-8. Read More

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November 2018

Spread Through Air Spaces (STAS): A New Pathologic Morphology in Lung Cancer.

Clin Lung Cancer 2018 Oct 26. Epub 2018 Oct 26.

Department of Thoracic Surgery, Zhongshan Hospital of Fudan University, Shanghai, China.

In 2015, the World Health Organization classification of lung cancer proposed the concept of spread through air spaces (STAS) as a new pattern of invasion in lung adenocarcinoma. The definition of STAS included one or more pathologic micropapillary clusters, solid nests or single cells beyond the edge of the tumor into air spaces in the surrounding lung parenchyma, and separation from the main tumor other than tumor islands. The roles of STAS has been investigated in many studies. Read More

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October 2018
2 Reads

Comparison of p63/p40 Expression With Myoepithelial Markers in Minor Salivary Gland Tumors.

Int J Surg Pathol 2018 Nov 27:1066896918813678. Epub 2018 Nov 27.

1 São Leopoldo Mandic Institute and Research Center, Campinas, São Paulo, Brazil.

The present study aimed to compare the expression of p63/p40 with smooth muscle actin (SMA) and vimentin (VIM) by myoepithelial cells in minor salivary gland tumors. Fifty-two formalin-fixed paraffin-embedded samples of minor salivary gland tumors derived from intercalated duct (pleomorphic adenoma [PA], adenoid cystic carcinoma [ACC], epithelial-myoepithelial carcinoma [EMC], polymorphous adenocarcinoma [PAC], and secretory carcinoma [SC]) and 3 samples of minor salivary gland tumors derived from excretory duct (mucoepidermoid carcinoma [MEC]) were evaluated by means of immunohistochemistry. The data were analyzed qualitatively. Read More

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November 2018

Giant Parotid Carcinosarcoma Arising in a Pleomorphic Adenoma: Facial Nerve Preservation by Retrograde Dissection.

OTO Open 2017 Jul-Sep;1(3):2473974X17719416. Epub 2017 Jul 3.

Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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July 2017
2 Reads

New species and records of Coryneum from China.

Mycologia 2018 Nov 27:1-17. Epub 2018 Nov 27.

a The Key Laboratory for Silviculture and Conservation of Ministry of Education , Beijing Forestry University , Beijing 100083 , China.

Following the abandonment of dual nomenclature and the implementation of single-name nomenclature for pleomorphic fungi, Coryneum was considered to have priority over Pseudovalsa and was recommended for use. Currently, Coryneum is the only genus in the family Coryneaceae (Diaporthales). However, DNA sequence data are lacking for most Coryneum species, and no detailed phylogenetic analyses of the genus are yet available. Read More

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November 2018
2 Reads

Common Variable Immunodeficiency-Associated Inflammatory Enteropathy: The New Era of Biological Therapy.

GE Port J Gastroenterol 2018 Nov 13;25(6):322-326. Epub 2018 Feb 13.

Gastroenterology Department, Hospital da Senhora da Oliveira, Guimarães, Portugal.

Common variable immunodeficiency (CVID) is the most frequent form of immunodeficiency in adults. Clinical manifestations are heterogeneous with an increased susceptibility to infections and inflammatory conditions, namely autoimmune diseases, such as inflammatory bowel disease. We present the clinical case of a Caucasian female patient, 21 years old, with a past medical history of CVID, with multiple visits to the emergency department due to abdominal pain in the lower quadrants and diarrhea. Read More

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November 2018
2 Reads

Epidemiology of salivary gland tumours in an Eastern Caribbean nation: A retrospective study.

Ann Med Surg (Lond) 2018 Dec 8;36:148-151. Epub 2018 Nov 8.

Department of Clinical Surgical Science, University of the West Indies, St. Augustine, Trinidad and Tobago.

Objective: The epidemiology of the salivary glands tumour is not well documented in the Caribbean countries. Therefore, the aim of this study is to determine the local trend of salivary gland tumours with a review of current diagnostic techniques.

Design & Methods: Retrospective data was collected from the electronic database at the Pathology department of the San Fernando Teaching Hospital between the periods January 2005 to June 2015. Read More

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December 2018
1 Read

Primary cutaneous peripheral T-cell lymphoma with a late relapse solely in the ileum mimicking monomorphic epitheliotropic intestinal T-cell lymphoma.

Pathol Res Pract 2018 Dec 21;214(12):2106-2109. Epub 2018 Oct 21.

Department of Pathology, Chi-Mei Medical Center, Tainan, Taiwan; Department of Pathology, School of Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Pathology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address:

Background: Primary cutaneous peripheral T-cell lymphomas (PC-PTCLs) are classified into mycosis fungoides (MF) and other rare specific types; and those do not fit into any specific entities are designated as PTCL, not otherwise specified (NOS), an aggressive neoplasm. Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is an aggressive primary intestinal T-cell lymphoma with enteropathy in the non-neoplastic mucosa. We report a rare case of PC-PTCL-NOS with a late relapse solely in the ileum after complete remission. Read More

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December 2018
4 Reads

Solitary fibrous tumor of the stomach with high-grade sarcomatous dedifferentiation.

J Surg Case Rep 2018 Nov 19;2018(11):rjy307. Epub 2018 Nov 19.

Department of Surgery, Creighton University Medical Center, Omaha, NE, USA.

Solitary fibrous tumors (SFT) are uncommon fibroblastic mesenchymal neoplasms that display a wide range of histologic behaviors. These tumors, which are estimated to account for 2% of all soft tissue neoplasms, typically follow a benign clinical course. However, it is estimated that 10-30% of SFTs are malignant and demonstrate aggressive behavior with local recurrence and metastasis up to several years after surgical resection. Read More

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November 2018
4 Reads

Genetic Profiles for Systemic Lupus Erythematosus in Han Chinese Population: From Genome-Wide Association Study to Exome-Wide Association Study.

J Investig Dermatol Symp Proc 2018 Dec;19(2):S95-S97

Department of Dermatology, China-Japan Friendship Hospital, Beijing, China; Graduate School of Peking Union Medical College, Beijing, China. Electronic address:

Systemic lupus erythematosus (SLE) is a chronic heterogeneous autoimmune disease characterized by loss of tolerance to self-antigens, complement activation, dysregulated type 1 IFN responses, and immune-mediated tissue damage. The clinical features of SLE are pleomorphic, affecting virtually any organ system, such as skin, joints, central nervous system, or kidneys. Currently, the etiology and pathogenesis of SLE are not fully understood. Read More

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December 2018
2 Reads

Spindle cell lipoma mimicking pleomorphic adenoma: A diagnostic challenge on cytology.

Diagn Cytopathol 2018 Nov 23. Epub 2018 Nov 23.

Department of Otorhinolaryngology, Government Medical College and Hospital, Chandigarh, India.

Spindle cell lipoma (SCL) is a benign neoplasm of mature adipose tissue mostly located in the neck, back, and shoulder region. It is composed of a variable admixture of adipocytes, benign spindle cells, and collagen fibres. While the histopathologic features of SCL are quite characteristic and well described, a cytologic diagnosis of SCL might be challenging. Read More

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November 2018
2 Reads

Clinical Utility of In Situ Hybridization Assays in Head and Neck Neoplasms.

Head Neck Pathol 2018 Nov 22. Epub 2018 Nov 22.

Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, Australia.

Head and neck pathology present a unique set of challenges including the morphological diversity of the neoplasms and presentation of metastases of unknown primary origin. The detection of human papillomavirus and Epstein-Barr virus associated with squamous cell carcinoma and newer entities like HPV-related carcinoma with adenoid cystic like features have critical prognostic and management implications. In salivary gland neoplasms, differential diagnoses can be broad and include non-neoplastic conditions as well as benign and malignant neoplasms. Read More

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November 2018
3 Reads

Chronic cavitary pneumonia by Rhodococcus equi in a highly prevalent tuberculosis country: a diagnosis challenge.

Rev Inst Med Trop Sao Paulo 2018 Nov 14;60:e74. Epub 2018 Nov 14.

Universidade Federal do Rio Grande do Norte, Departamento de Infectologia, Natal, Rio Grande do Norte, Brazil.

Rhodococcus equi is a facultative aerobic, intracellular, non-motile, non-spore-forming, Gram-positive, weakly acid-fast coccobacillus belonging to the group of nocardioform actinomycetes. R. equi infections are rare opportunistic illnesses in patients with Acquired Immunodeficiency Syndrome (AIDS), associated with a high mortality rate. Read More

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November 2018
3 Reads

Accuracy of diagnosing mantle cell lymphoma and identifying its variants on fine-needle aspiration biopsy.

Cancer Cytopathol 2018 Nov 19. Epub 2018 Nov 19.

Department of Anatomic Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: Mantle cell lymphoma (MCL) is an incurable B-cell lymphoma portending an aggressive clinical course; the blastoid and pleomorphic morphological variants have an even worse prognosis. In addition, patients with classic morphology and a high proliferation index (HPI), also have reduced survival. Although variants have been defined, to the authors' knowledge the ability to detect these subtypes by fine-needle aspiration biopsy (FNAB) has not been described. Read More

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November 2018
1 Read

The role of monogenic genes in idiopathic Parkinson's disease.

Neurobiol Dis 2018 Nov 15;124:230-239. Epub 2018 Nov 15.

Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA. Electronic address:

In the past two decades, mutations in multiple genes have been linked to autosomal dominant or recessive forms of monogenic Parkinson's disease (PD). Collectively, these monogenic (often familial) cases account for less than 5% of all PD, the majority being apparently sporadic cases. More recently, large-scale genome-wide association studies have identified over 40 loci that increase risk of PD. Read More

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November 2018
1 Read

Utility of JAK2 V617F allelic burden in distinguishing chronic Myelomonocytic leukemia from primary myelofibrosis with Monocytosis.

Hum Pathol 2018 Nov 15. Epub 2018 Nov 15.

Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address:

The concurrent presence of JAK2 V617F, monocytosis and bone marrow fibrosis can be observed in both chronic myelomonocytic leukemia (CMML) and primary myelofibrosis (PMF). It can be challenging to distinguish CMML with JAK2 mutation and fibrosis from other myeloid neoplasms, particularly PMF. To identify key features that may help distinguish these two entities, we retrospectively studied 21 cases diagnosed as "CMML" with JAK2 V617F and bone marrow fibrosis that were identified from a cohort of 610 cases of CMML diagnosed during 2006-2016. Read More

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November 2018
1 Read

Pleomorphic adenoma of the head and neck in children: presentation and management.

Laryngoscope 2018 Nov 15. Epub 2018 Nov 15.

Department of Otolaryngology and Communication Enhancement, Boston, Massachusetts, U.S.A.

Objective: Pleomorphic adenoma is the most common benign salivary gland neoplasm in children. Recurrence and malignant transformation are concerns necessitating proper treatment. The goal of this research was to discuss the presentation, evaluation, and management of pediatric pleomorphic adenoma of the head and neck. Read More

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November 2018
10 Reads

The role of adjuvant radiotherapy in management of recurrent pleomorphic adenoma of the parotid gland: a systematic review.

Eur Arch Otorhinolaryngol 2018 Nov 13. Epub 2018 Nov 13.

Department of Otorhinolaryngology, Galway University Hospital, Galway, Ireland.

Purpose: Recurrent pleomorphic adenoma poses a significant treatment challenge, considering its propensity for further recurrence and potential for malignant transformation. The role of adjuvant radiotherapy in its management is widely debated. The aim of this study was to determine whether adjuvant radiotherapy is more effective than surgical resection alone in patients with recurrent pleomorphic adenoma of the parotid gland, in terms of further recurrence, malignant transformation and treatment-related complications. Read More

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November 2018
4 Reads

Wolbachia Population in Vectors and Non-vectors: A Sustainable Approach Towards Dengue Control.

Curr Microbiol 2018 Nov 13. Epub 2018 Nov 13.

Division of Medical Entomology, Regional Medical Research Centre, Indian Council of Medical Research, Nalco Square, Chandrasekharpur, Bhubaneswar, 751023, India.

Wolbachia is gram negative obligate endosymbiont known for reproductive manipulation in the host. It is important to study the presence of natural Wolbachia in mosquitoes which can later help in understanding the effect of transfected strain on indigenous strain. With this view, the present study is undertaken to focus on the prevalence, diversity, infection frequencies, phylogeny and density of indigenous Wolbachia strains in wild mosquito species of Odisha. Read More

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November 2018
1.420 Impact Factor

PLAG1, SOX10, and Myb Expression in Benign and Malignant Salivary Gland Neoplasms.

J Pathol Transl Med 2018 Nov 14. Epub 2018 Nov 14.

Department of Pathology, National Cancer Center, Goyang, Korea.

Background: Recent findings in molecular pathology suggest that genetic translocation and/or overexpression of oncoproteins is important in salivary gland tumorigenesis and diagnosis. We investigated PLAG1, SOX10, and Myb protein expression in various salivary gland neoplasm tissues.

Materials And Methods: A total of 113 cases of surgically resected salivary gland neoplasms at the National Cancer Center from January 2007 to March 2017 were identified. Read More

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November 2018
4 Reads

Influence of age and subtype in outcome of operable liposarcoma.

Radiol Med 2018 Nov 12. Epub 2018 Nov 12.

Department of Radiation Oncology, Azienda Ospedaliero Universitaria Careggi, University of Florence, Largo Brambilla 3, 50141, Florence, Italy.

Aim: Liposarcoma (LPS) is rare tumor deriving from adipocytes. LPS is classified into histological subtypes: well-differentiated (WDLPS), dedifferentiated (DDLPS), myxoid (MLPS) and pleomorphic (PLPS). A tailored approach taking into account the specificity of disease subtype and age at presentation could be helpful in delineating therapeutic management of liposarcoma. Read More

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November 2018
2 Reads

Atypical mitoses are present in otherwise classical pleomorphic lipomas.

Hum Pathol 2018 Nov 3;81:299-300. Epub 2018 Jul 3.

Department of Pathology, Hacettepe University Faculty of Medicine, 06100 Ankara, Turkey. Electronic address:

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November 2018
1 Read

Technique of The Buccal Fat Pad Flap as an Alternative for the Surgical Defect of Pleomorphic Adenoma.

J Craniofac Surg 2018 Nov 9. Epub 2018 Nov 9.

Batista Memorial Hospital, Fortaleza, Brazil.

Pleomorphic adenoma (PA) is the most common benign salivary gland neoplasm, and its malignant transformation rarely occurs. Diagnosis is based on clinical features of local or regional malignancy or distant metastasis, and histological identification of invasion and cellular atypia. Buccal fat pad, also called Bichat fat pad, is an excellent option to create tissue coverage over surgically treated areas, providing great blood supply. Read More

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November 2018
5 Reads

"Integrated diagnosis" of pilocytic astrocytoma: Molecular diagnostic procedure for an unusual case.

Pathol Int 2018 Nov 12. Epub 2018 Nov 12.

Department of Cancer Pathology, Faculty of Medicine, Hokkaido University, Sapporo, Japan.

A 24 year-old female presented with a mass lesion in the right temporal lobe. This case was difficult to diagnose using histological and immunological methods and therefore molecular analyses were applied to provide a definitive diagnosis. The tumor was well-demarcated, partially cystic, and irregularly-enhanced on gadolinium-enhanced T1-weighted magnetic resonance images. Read More

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November 2018
5 Reads

The impact of histology and ground-glass opacity component on volume doubling time in primary lung cancer.

J Thorac Dis 2018 Sep;10(9):5428-5434

Division of General Thoracic Surgery, Integrative Center of General Surgery, Gunma University Hospital, Maebashi, Gunma, Japan.

Background: Correlations between volume doubling time (VDT) of primary lung cancer (PLC), histology, and ground glass opacity (GGO) components remain unclear. The purpose of this study was to evaluate and compare VDT of PLC in terms of histology and presence or absence of GGO components.

Methods: A total of 371 surgically resected PLCs from 2003 to 2015 in our institute were retrospectively reviewed. Read More

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September 2018
2 Reads

Pleomorphic carcinoma of the lung mimicking synchronous pulmonary adenocarcinoma and small bowel sarcoma.

Ann Thorac Med 2018 Oct-Dec;13(4):251-253

Department of Pathology, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, Seoul, Korea.

Pulmonary pleomorphic carcinoma is defined as a nonsmall cell lung carcinoma (NSCLC) that contains at least 10% sarcomatoid components. We report a case of pulmonary pleomorphic carcinoma of which only the sarcomatoid component metastasized to the small bowel and adenocarcinoma was identified on percutaneous transthoracic needle biopsy (PTNB). We suggest that if an NSCLC is diagnosed by PTNB and a sarcoma is found at another site, or vice versa, pulmonary pleomorphic carcinoma with a single metastasis should be considered as a differential diagnosis to establish the best effective treatment plan. Read More

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November 2018
3 Reads

Prognostic Factors, Treatment, and Survival in Cutaneous Pleomorphic Sarcoma.

J Am Acad Dermatol 2018 Nov 8. Epub 2018 Nov 8.

Case Western Reserve University, School of Medicine, Cleveland, OH; Cleveland Clinic Foundation, Department of Dermatology, Cleveland, OH. Electronic address:

Background: Limited information exists on the influence of demographics, tumor characteristics, and treatment on survival in cutaneous pleomorphic sarcoma (CPS).

Objective: To describe incidence rates and prognostic factors affecting survival in CPS.

Methods: National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) data (1972-2013) was analyzed for 2423 patients diagnosed with CPS. Read More

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November 2018
4 Reads

Parapharyngeal Space Venous Malformation: An Imaging Mimic of Pleomorphic Adenoma.

AJNR Am J Neuroradiol 2018 Nov 8. Epub 2018 Nov 8.

From the Departments of Radiology (C.M.T., G.P.F., J.M.H.)

Venous malformations in the parapharyngeal space are rare and may be challenging to diagnose with imaging secondary to multiple overlapping features with pleomorphic adenoma, which is much more commonly found in this region. While both lesions are T1 isointense and T2 hyperintense relative to skeletal muscle and demonstrate contrast enhancement, more uniform T2 hyperintensity and progressive contrast pooling on delayed postcontrast T1WI may allow the radiologist to include venous malformation in the differential diagnosis. This is important because it has the potential to alter management from surgical resection to observation. Read More

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November 2018
3 Reads

Leiomyosarcoma and Pleomorphic Dermal Sarcoma: Guidelines for Diagnosis and Treatment.

Actas Dermosifiliogr 2018 Nov 5. Epub 2018 Nov 5.

Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, España.

There are 3 types of leiomyosarcoma of the skin: dermal, subcutaneous, and metastatic cutaneous. Dermal leiomyosarcoma arises from smooth muscle fibers in arrector pili muscles, genital dartos muscles, and the nipple-areola complex. It is an intermediate-grade tumor associated with a tendency for local recurrence (24%) and low metastatic potential (4%). Read More

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November 2018
3 Reads

A case of primary cutaneous peripheral T-cell lymphoma, not otherwise specified with cytotoxic phenotype showing multiple ulcers on the entire body.

J Cutan Pathol 2018 Nov 8. Epub 2018 Nov 8.

Department of Dermatology, Kitasato University School of Medicine, Kanagawa, Japan.

Primary cutaneous peripheral T cell lymphoma, not otherwise specified (pcPTCL-NOS) is a rare, aggressive, fatal type of cutaneous T-cell lymphoma. The clinical presentation of pcPTCL-NOS is characterized by generalized plaques, nodules or tumours but ulcers are uncommon. We report an atypical case of pcPTCL-NOS with cytotoxic protein expression, presenting as multiple ulcers on the entire body. Read More

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November 2018
10 Reads

Status of programmed death-ligand 1 expression in sarcomas.

J Transl Med 2018 Nov 6;16(1):303. Epub 2018 Nov 6.

Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, South Korea.

Background: Sarcomas are challenging to study because of their rarity and histomorphological complexity. PD1 and PD-L1 inhibitors showed a promising anti-tumor effect in solid tumors, where a relationship between PD-L1 expression and the objective response has been evidenced.

Methods: In this study, we examined PD-L1 expression in 16 bone and soft tissue sarcoma cell lines of 11 different subtypes by means of western blot, flow cytometry and immunocytochemistry, and in 230 FFPE patient-derived tumor tissues by means of immunohistochemistry using three different antibody clones. Read More

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November 2018
5 Reads

Atypical lipomatous tumor in the ligamentum teres of liver: A case report and review of the literature.

World J Clin Cases 2018 Oct;6(12):548-553

Department of Gastroenterology, Kanazawa Medical University Himi Municipal Hospital, Himi-shi, Toyama-ken 935-8531, Japan.

A 61-year-old male was referred to our hospital with a three-month history of persistent epigastralgia and right hypochondralgia. Initial examination revealed a fist-size mass at the epigastric fossa. Ultrasonography showed a hemangioma and a mosaic echoic lesion in the ventromedian with poor blood-flow signal and linear hyperechoic part inside, and a clear border to the surroundings. Read More

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October 2018
7 Reads