6,188 results match your criteria Pleomorphic Adenoma


Clinicopathologic Features and Prognostic Factors of Widely Invasive Carcinoma Ex Pleomorphic Adenoma of Parotid Gland: A Clinicopathologic Analysis of 126 Cases in a Chinese Population.

J Oral Maxillofac Surg 2020 Jun 13. Epub 2020 Jun 13.

Professor and Department Head, Department of Oral Pathology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine National Clinical Research Center for Oral Disease and Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, Shanghai, China. Electronic address:

Purpose: Salivary intracapsular carcinoma ex pleomorphic adenoma (ICCXPA) and minimally invasive CXPA (MICXPA) generally have favorable outcomes. In contrast, widely invasive CXPA (WICXPA) frequently results in disease-related death. The aims of the present study were to analyze the differences in the clinicopathologic features between parotid gland ICCXPA or MICXPA and WICXPA and the prognostic factors for WICXPA. Read More

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http://dx.doi.org/10.1016/j.joms.2020.06.013DOI Listing

Differentiation of salivary gland tumor using diffusion-weighted imaging with a fractional order calculus model.

Br J Radiol 2020 Jul 10:20200052. Epub 2020 Jul 10.

Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Objective: To evaluate the feasibility of using imaging parameters (D, β and μ) obtained from fractional order calculus (FROC) diffusion model to differentiate salivary gland tumors.

Methods: 15 b-value (0-2000 s/mm) diffusion-weighted imaging (DWI) was scanned in 62 patients with salivary gland tumors (47 benign and 15 malignant). Diffusion coefficient D, fractional order parameter β (which correlates with tissue heterogeneity) and a microstructural quantity μ of the solid portion within the tumor were calculated, and compared between benign and malignant groups, or among pleomorphic adenoma (PA), Warthin's tumor (WT), and malignant tumor (MT) groups. Read More

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http://dx.doi.org/10.1259/bjr.20200052DOI Listing

Nanoscale infrared probing of amyloid formation within the pleomorphic adenoma tissue.

Biochim Biophys Acta Gen Subj 2020 Jul 4:129677. Epub 2020 Jul 4.

Institute of Nuclear Physics Polish Academy of Sciences, PL-31342 Krakow, Poland.

Background: The process of malignant transformations of many tumour cases is still unclear and more specific experimental approaches are necessary. The detailed identification of the pathological changes may help in the therapy progression through the development of drugs with more selective action.

Methods: In this study, the AFM-IR nanospectroscopy was applied for the first time to the pleomorphic adenoma (TM) and the marginal tissue characterizations. Read More

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http://dx.doi.org/10.1016/j.bbagen.2020.129677DOI Listing

Differentiation of salivary gland tumors through tumor heterogeneity: a comparison between pleomorphic adenoma and Warthin tumor using CT texture analysis.

Neuroradiology 2020 Jul 3. Epub 2020 Jul 3.

Department of Radiology, Ajou University School of Medicine, Ajou University Medical Center, 164, World Cup-ro, Yeongtong-gu, Suwon, Republic of Korea, 16499.

Purpose: We compared the diagnostic performance of CT texture analysis in single-phase CT scan with that of conventional enhancement pattern analysis in a two-phase CT scan for discrimination of salivary gland tumors, Warthin tumor (WT) from pleomorphic adenoma (PA).

Methods: One hundred seventy-eight patients with PA and 84 patients with WT were selected and CT texture analysis was separately performed on early (40s) and delayed (180s) phases, after injection of the contrast agent, using commercially available software. The attenuation changes and enhancement patterns were visually and quantitatively assessed with Hounsfield units (HU). Read More

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http://dx.doi.org/10.1007/s00234-020-02485-xDOI Listing

Trends in parotidectomy over 30 years in an Australian tertiary care center.

Head Neck 2020 Jul 3. Epub 2020 Jul 3.

Head and Neck Oncology, Sydney Head and Neck Cancer Institute, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.

Background: Nomenclature, classification, and management of parotid tumors are constantly evolving; this study was performed to identify temporal trends in histology and facial nerve sacrifice in parotidectomy during a 30-year period (1987-2018).

Methods: Retrospective analysis of patients treated in a single tertiary-care institution during this time period was performed with analysis of temporal trends.

Results: Two thousand eight hundred and fifty-seven parotidectomies were performed; pleomorphic adenoma was the most common histology (34. Read More

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http://dx.doi.org/10.1002/hed.26335DOI Listing

Pleomorphic Adenoma of the Parotid Gland and Ipsilateral Thyroid Incidentaloma: Report of A Rare Case With Review of Literature.

Transl Med UniSa 2020 May 31;22:15-18. Epub 2020 May 31.

Department of Sense Organs, University Sapienza of Rome, Italy.

Background: Pleomorphic adenomas are benign tumors of the salivary glands that mainly affect the lower pole of the superficial lobe of the parotid gland. The term "pleomorphic" refers to the epithelial and connective origin of the mass. The clinical presentation is typically that of asymptomatic swelling which increases in volume. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265912PMC

Diagnostic Value of Superb Microvascular Imaging in Parotid Tumors.

Med Sci Monit 2020 Jun 8;26:e921813. Epub 2020 Jun 8.

Department of Ultrasound Diagnosis and Treatment, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China (mainland).

BACKGROUND The aim of this study was to evaluate the clinical diagnostic value of superb microvascular imaging (SMI) in assessing vascular distribution, vascularity, and vessel morphology of parotid tumors (PTs). MATERIAL AND METHODS PT patients confirmed by postoperative histopathological detection and who underwent color Doppler flow imaging (CDFI), microvascular imaging (MVI), and SMI examination were recruited. PTs were classified into 3 groups: pleomorphic adenoma (PA), Warthin tumor (WT), and malignant PT (MT). Read More

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http://dx.doi.org/10.12659/MSM.921813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297036PMC

Retrospective Study of Buccal Mucosal Salivary Neoplasms.

Head Neck Pathol 2020 Jun 6. Epub 2020 Jun 6.

Department of Oral and Maxillofacial Diagnostic Sciences, University of Florida College of Dentistry, 1395 Center Drive, Gainesville, FL, 32610, USA.

Salivary gland neoplasms of the buccal mucosa are relatively rare and often present with an unusual histopathologic profile when compared with other intraoral locations. We present a series of minor salivary gland neoplasms of the buccal mucosa and discuss demographics, clinical presentation, and histologic findings. An IRB approved retrospective search of University of Florida Oral Pathology Biopsy Service archive from 1994 to 2018 for all salivary gland neoplasms of the buccal mucosa was undertaken. Read More

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http://dx.doi.org/10.1007/s12105-020-01190-8DOI Listing

A Modified Technique in Submandubular Salivary Gland Excision: Preservation of Facial Artery.

Mymensingh Med J 2020 Apr;29(2):361-365

Professor Dr Sheikh Hasanur Rahman, Professor, Department of Otolaryngology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh; E-mail:

Cutting and ligation of facial artery is the conventional practice for excision of submandibular gland. Facial artery is the main arterial supply to the lower face. Its preservation results in preservation of large proportion of vascularity to the lower face, preserves vascularity of platysma myocutaneous flap, allows repair of lower lip using Bernard's technique; facial artery is one of the most important recipient artery for microvascular free flap in modern reconstructive surgery in head and neck oncology. Read More

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Signet Ring Cell Differentiation in Salivary Duct Carcinoma with Rhabdoid Features: Report of Three Cases and Literature Review.

Head Neck Pathol 2020 Jun 2. Epub 2020 Jun 2.

Section of Oncopathology and Regenerative Biology, Department of Pathology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.

Salivary duct carcinoma with rhabdoid features (SDCRF) is a rare salivary tumor with poor prognosis and is proposed as a salivary counterpart of pleomorphic lobular carcinoma of the breast (PLCB). Here, we report three cases of SDC with rhabdoid features (SDCRF) mimicking PLCB. Pleomorphic adenoma (PA) component was accompanied in all the cases confirming carcinoma ex PA. Read More

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http://dx.doi.org/10.1007/s12105-020-01186-4DOI Listing

Comparison of Surgical Outcomes of Robotic and Conventional Approaches in Patients with Pre- and Poststyloid Parapharyngeal Space Tumors.

Ann Surg Oncol 2020 May 30. Epub 2020 May 30.

Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Republic of Korea.

Background: Benefits and drawbacks of robotic surgical approaches for parapharyngeal space (PPS) tumors remain undetermined. The purpose of this study is to compare surgical outcomes of PPS tumor patients who underwent robotic surgery with those of patients who received conventional surgical treatment.

Patients And Methods: We retrospectively analyzed clinicopathologic data from 136 patients who underwent surgical removal of PPS tumors via conventional or robotic approaches. Read More

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http://dx.doi.org/10.1245/s10434-020-08536-0DOI Listing

Amide proton transfer (APT) imaging of parotid tumors: Differentiation of malignant and benign tumors.

Eur J Radiol 2020 May 21;129:109047. Epub 2020 May 21.

Department of Health Sciences, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

Purpose: To assess the usefulness of amide proton transfer (APT) imaging in differentiating parotid tumors.

Material And Methods: We retrospectively analyzed 43 histopathologically proven parotid solid tumors with diameters ≥2 cm. Twenty-one tumors were benign and 12 tumors were malignant. Read More

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http://dx.doi.org/10.1016/j.ejrad.2020.109047DOI Listing

Microvesicles derived from squamous cell carcinoma induce cell death, autophagy, and invasion of benign myoepithelial cells.

J Oral Pathol Med 2020 May 26. Epub 2020 May 26.

Cell Biology and Oral Pathology Division, Faculdade São Leopoldo Mandic, Campinas, SP, Brazil.

Background: There has been great interest recently in the mechanisms of cell-to-cell communication through microvesicles (MV). These structures are produced by many different cell types and can modulate cellular activity by induction of epigenetic alterations. These vesicles may promote tumor mass increase either by stimulating cell proliferation via growth factors or by inhibiting apoptosis, which reinforces the role of such vesicles as important modulators of tumor progression. Read More

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http://dx.doi.org/10.1111/jop.13037DOI Listing

Sublingual Gland Tumors Worldwide: A Descriptive Retrospective Study of 839 Cases.

J Oral Maxillofac Surg 2020 Apr 25. Epub 2020 Apr 25.

Associate Professor, Department of Oral and Maxillofacial Surgery, Stomatological Hospital of Chongqing Medical University, Chongqing, People's Republic of China; and Research Fellow, Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Boston, MA. Electronic address:

Purpose: Sublingual gland tumors are rare. We sought to define the general features of sublingual gland tumors for clinical reference. In addition, we evaluated whether it would be safe to speculate that ∼90% sublingual gland tumors will be malignant and that ∼90% of those malignant tumors will be adenoid cystic carcinoma. Read More

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http://dx.doi.org/10.1016/j.joms.2020.04.023DOI Listing

Pleomorphic Adenoma of External Auditory Canal: Case Report of First Endoscopic Resection and Literature Review.

Medicina (Kaunas) 2020 May 20;56(5). Epub 2020 May 20.

Department of Otorhinolaryngology, Head and Neck Surgery, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.

Ceruminous pleomorphic adenoma is a very rare, mostly benign tumor originating from the ceruminal glands in the external auditory canal. Histologically, it is a mixed tumor with epithelial and stromal parts of different proportions, and is recognized today by the World Health Organization (WHO) as a ceruminous adenoma. Similar to the pleomorphic adenoma of salivary glands, recurrence or malignant degeneration with cellular atypia and metastasis can occur on rare occasions. Read More

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http://dx.doi.org/10.3390/medicina56050248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279297PMC

Evaluation of VEGF expression correlates with COX-2 expression in pleomorphic adenoma, mucoepidermoid carcinoma and adenoid cystic carcinoma.

Dent Res J (Isfahan) 2020 Mar-Apr;17(2):100-106. Epub 2020 Mar 17.

Department of Endodontics, School of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.

Background: Pleomorphic adenoma (PA), mucoepidermoid carcinoma (MEC), and adenoid cystic carcinoma (AdCC) are the most common benign and malignant salivary gland tumors. Cyclooxygenase-2 (COX-2) is a key regulatory enzyme that its overexpression in various tumors is correlated with progression, metastasis, and apoptosis inhibition. Vascular endothelial growth factor (VEGF) is a potent angiogenic mediator that has an important role in neoplastic angiogenesis. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224257PMC

Value of quantitative multiparametric MRI in differentiating pleomorphic adenomas from malignant epithelial tumors in lacrimal gland.

Neuroradiology 2020 May 19. Epub 2020 May 19.

Department of Radiology, Beijing Tongren Hospital, Capital Medical University, No. 1, Dongjiaominxiang, Dongcheng District, Beijing, 100730, China.

Purpose: To evaluate the diagnostic performance of the quantitative parameters derived from diffusion-weighted imaging (DWI) and dynamic contrast-enhanced (DCE) MRI in differentiating lacrimal gland pleomorphic adenomas (LGPAs) from lacrimal gland malignant epithelial tumors (LGMETs).

Methods: Seventy-seven cases with LG epithelial tumors confirmed by histopathology (47 LGPAs and 30 LGMETs) underwent DWI and DCE-MRI. The quantitative parameters including the apparent diffusion coefficient (ADC), the volume transfer constant (K), the efflux rate constant from the extravascular extracellular space (EES) to blood plasma (K), and the extravascular extracellular volume fraction (V) were used to differentiate LGPAs from LGMETs. Read More

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http://dx.doi.org/10.1007/s00234-020-02455-3DOI Listing

Fine needle aspiration cytology of polymorphous adenocarcinoma of the salivary glands: A report of 11 patients and review of the literature.

Diagn Cytopathol 2020 May 18. Epub 2020 May 18.

Department of Pathology, University Hospital La Paz, Madrid, Spain.

Background: Polymorphous adenocarcinoma (PAC) is a rare malignant tumor of the minor salivary glands. It has an infiltrative growth, variable architectural patterns, neurotropism and cellular monomorphism. Approximately 75% of the cases show a specific mutation in the protein kinase D1 (PRKD1) gene. Read More

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http://dx.doi.org/10.1002/dc.24473DOI Listing

Multifocal Parotid Oncocytic Cystadenomatosis: A Rare Process that Can Mimic Malignancy.

Head Neck Pathol 2020 May 14. Epub 2020 May 14.

THANC (Thyroid, Head and Neck Cancer) Foundation, 10 Union Square East, Suite 5B, New York, NY, 10003, USA.

Multifocal cystic oncocytosis (MCO) is a rare, benign process accounting for approximately 0.1% of salivary gland lesions. Salivary oncocytosis is characterized by multiple unencapsulated solid nodules of oncocytic cells derived from transformed striated ducts. Read More

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http://dx.doi.org/10.1007/s12105-020-01170-yDOI Listing

Extracapsular Dissection in Pleomorphic Adenomas of the Parotid Gland: Results After 13 Years of Follow-up.

Laryngoscope 2020 May 12. Epub 2020 May 12.

Department of Otorhinolaryngology-Head and Neck Surgery, Friedrich-Alexander University Medical School, University of Erlangen-Nuremberg, Erlangen, Germany.

Objectives/hypothesis: To assess long-term results after the treatment of parotid pleomorphic adenomas (PPAs) using different surgical techniques and focusing on recurrence rates and the risk of adverse effects.

Study Design: Retrospective analysis.

Methods: Retrospective analysis of 182 patients treated exclusively for PPAs at a tertiary referral center between 2000 and 2004. Read More

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http://dx.doi.org/10.1002/lary.28696DOI Listing

Radiographic surveillance of abdominal free fat graft in complex parotid pleomorphic adenomas: A case series.

Heliyon 2020 May 4;6(5):e03894. Epub 2020 May 4.

Department of Otolaryngology - Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.

Background: Free abdominal fat transfer is commonly used to restore facial volume and improve cosmesis after parotidectomy for pleomorphic adenomas. We describe the radiographic characteristics of these grafts on follow-up imaging.

Methods: Medical records of four patients who underwent parotidectomy with abdominal fat graft in 2016 and had follow up imaging available were retrospectively analyzed. Read More

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http://dx.doi.org/10.1016/j.heliyon.2020.e03894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210407PMC

Epidemiologic analysis of salivary gland tumors over a 10-years period diagnosed in a northeast Brazilian population.

Med Oral Patol Oral Cir Bucal 2020 Jul 1;25(4):e516-e522. Epub 2020 Jul 1.

Laboratory of Morphology and Experimental Pathology Institute of Technology and Research, Tiradentes University Av. Murilo Dantas, 300, Farolândia, Aracaju, SE 49032-490, Brazil

Background: Salivary gland tumors (SGT) correspond to a heterogeneous group of lesions with variable biological behavior. The present study aimed to determine the distribution and demographic findings of salivary gland neoplasms in a northeast Brazilian population.

Material And Methods: A retrospective descriptive cross-sectional study was performed. Read More

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http://dx.doi.org/10.4317/medoral.23532DOI Listing

Revisiting the distinct histomorphologic features of inflammatory bowel disease-associated neoplastic precursor lesions in the SCENIC and post-DALM Era.

Hum Pathol 2020 Jun 5;100:24-37. Epub 2020 May 5.

Division of Gastroenterology, University of Washington School of Medicine, Seattle, 98195, USA.

Distinct histomorphologic features of colitis-associated dysplasia (CAD) or neoplastic precursors in inflammatory bowel disease (IBD) have never been clearly identified. In this study, we tried to further explore the differentiating morphologic features of CAD by retrospectively reviewing the lesions that were clearly associated with carcinomas (carcinoma-related lesions) and by comparing between endoscopically nonpolypoid (non-adenoma-like) lesions and polypoid (adenoma-like) lesions and sporadic conventional adenomas found in the noncolitic mucosa and in patients without IBD. Our study results have revealed that (1) precursor lesions related to IBD-associated colorectal carcinomas were almost always nonpolypoid in macroscopic/endoscopic appearance; (2) nearly half of the carcinoma-related lesions and nonpolypoid lesions were similarly nonadenomatous (nonconventional) lesions, largely serrated type, with no or only mild/focal adenomatous dysplasia, and commonly had mixed adenomatous and nonadenomatous features; (3) carcinoma-related and nonpolypoid adenomatous dysplastic lesions frequently showed some peculiar histocytologic features that we observed and described for the first time, including mixed features of inflammatory pseudopolyps or granulation tissue, pleomorphic and disarrayed nuclei, micropapillary or hobnailing surface epithelial cells, and microvesicular or bubbling cytoplasm of dysplastic cells; and (4) polypoid lesions in the colitic mucosa were identical to sporadic adenomas in the noninflamed mucosa and in patients without IBD, and they lacked the aforementioned features. Read More

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http://dx.doi.org/10.1016/j.humpath.2020.04.010DOI Listing

Palpebral Pleomorphic Adenomas of the Lacrimal Gland.

Ophthalmic Plast Reconstr Surg 2020 May 4. Epub 2020 May 4.

Adnexal Service, Moorfields Eye Hospital, London, United Kingdom.

Aims: To report the characteristics and management for patients with palpebral pleomorphic adenoma of the lacrimal gland.

Methods: The records for patients with palpebral pleomorphic adenoma seen at Moorfields Eye Hospital between 1978 and 2019 were reviewed for demographics, presentation, imaging, histopathology, management, and outcome.

Results: Forty-three patients (25 male; 58%) with palpebral pleomorphic adenoma were identified, presenting at a mean age of 46 years (median 46. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001682DOI Listing

A Preliminary Study of CT Texture Analysis for Characterizing Epithelial Tumors of the Parotid Gland.

Cancer Manag Res 2020 21;12:2665-2674. Epub 2020 Apr 21.

Department of Radiology, Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing 400014, People's Republic of China.

Objective: The aim of this study was to explore and validate the diagnostic performance of whole-volume CT texture features in differentiating the common benign and malignant epithelial tumors of the parotid gland.

Materials And Methods: Contrast-enhanced CT images of 83 patients with common benign and malignant epithelial tumors of the parotid gland confirmed by histopathology were retrospectively analyzed, including 50 patients with pleomorphic adenoma (PA) and 33 patients with malignant epithelial tumors. Quantitative texture features of tumors were extracted from CT images of arterial phase. Read More

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http://dx.doi.org/10.2147/CMAR.S245344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183330PMC

Expression of TdT in Myoepithelial Cells: Investigation in Breasts, Sweat Glands, and Salivary Lesions Emphasizing the Never-Documented Immunohistochemical Findings.

Int J Surg Pathol 2020 May 4:1066896920916792. Epub 2020 May 4.

Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

. The expression of terminal deoxynucleotidyl transferase (TdT) in myoepithelial cells (MECs) within the breast was recently incidentally observed in our routine practice. This study aimed to elucidate the expression of TdT in MECs. Read More

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http://dx.doi.org/10.1177/1066896920916792DOI Listing

and Fusion Genes in Chondroid Syringoma.

Cancer Genomics Proteomics 2020 May-Jun;17(3):237-248

Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.

Background/aim: Chondroid syringoma is a rare benign tumor emanating from sweat glands. Although rearrangements of the pleomorphic adenoma gene 1 (PLAG1) have been reported in such tumors, information on PLAG1 fusion genes is very limited.

Materials And Methods: Cytogenetic, fluorescence in situ hybridization, RNA sequencing, array comparative genomic hybridization, reverse transcription polymerase chain reaction, and Sanger sequencing analyses were performed on two chondroid syringoma cases. Read More

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http://dx.doi.org/10.21873/cgp.20184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259886PMC
January 2020

PLAGL2-EGFR-HIF-1/2α signaling loop promotes HCC progression and Erlotinib insensitivity.

Hepatology 2020 Apr 25. Epub 2020 Apr 25.

Center for New Drug Safety Evaluation and Research, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 211198, China.

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide hence a major public health threat. Pleomorphic adenoma gene like-2 (PLAGL2) has been reported to play a role in tumorigenesis. However, its precise function in HCC remains poorly understood. Read More

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http://dx.doi.org/10.1002/hep.31293DOI Listing

Prominent oncocytic metaplasia in pleomorphic adenoma: A potential diagnostic pitfall.

Diagn Cytopathol 2020 Aug 25;48(8):765-768. Epub 2020 Apr 25.

Department of Pathology and Laboratory Medicine, Kansai Medical University, Osaka, Japan.

Pleomorphic adenoma (PA) is the most common salivary gland tumor. The cytological features of PA are well recognized, and its diagnosis is straightforward in most cases. Some metaplastic changes in PA are well known; however, occurrence of oncocytic metaplasia in PA is very rare. Read More

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http://dx.doi.org/10.1002/dc.24443DOI Listing

Epithelial-Myoepithelial Carcinoma of the Lacrimal Gland: Case Report of Youngest Patient.

Ophthalmic Plast Reconstr Surg 2020 Apr 17. Epub 2020 Apr 17.

Ophthalmology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences.

The authors report a case of extremely uncommon malignancy of lacrimal gland epithelial-myoepithelial carcinoma. This carcinoma is more commonly encountered in salivary glands and comprises 1% of all salivary gland tumors. Its occurrence in the orbit is very rare with only 6 cases reported in the literature, most of which arose in a pleomorphic adenoma. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001663DOI Listing

Concurrent presence of secretory carcinoma and Warthin's tumor in ipsilateral parotid gland.

Oral Oncol 2020 Apr 21:104691. Epub 2020 Apr 21.

DeWitt Daughtry Family Department of Surgery, Division of Oral and Maxillofacial Surgery, Section of Head and Neck Surgical Oncology/, Microvascular Reconstructive Surgery, University of Miami, Miller School of Medicine/Jackson Health System, Deering Medical Plaza, 9380 SW 150(th) St #170, Miami, FL 33176, United States. Electronic address:

Background: The presence of synchronous benign and malignant salivary gland neoplasms is very rare. The authors present a previously unreported combination of Secretory Carcinoma (SC) and Warthin's Tumor (WT) within the same parotid gland.

Methods: The patient presented with increasingly painful enlargement of the left parotid gland. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2020.104691DOI Listing

Added value of susceptibility-weighted imaging to diffusion-weighted imaging in the characterization of parotid gland tumors.

Eur Arch Otorhinolaryngol 2020 Apr 23. Epub 2020 Apr 23.

Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, No. 300, Guangzhou Rd., Nanjing, People's Republic of China.

Purpose: To assess the added value of susceptibility-weighted imaging (SWI) to diffusion-weighted imaging (DWI) in the characterization of parotid gland tumors.

Methods: Seventy-eight patients with pathologically confirmed parotid gland tumors, who underwent DWI and SWI for pre-surgery evaluation, were enrolled. Apparent diffusion coefficient (ADC) and degree of intratumoral susceptibility signal intensity (ITSS) were measured and compared between benign and malignant groups, and among pleomorphic adenoma (PA), Warthin tumor (WT) and malignant tumor (MT). Read More

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http://dx.doi.org/10.1007/s00405-020-05985-xDOI Listing

Management of Parapharyngeal Space Tumor Using Transoral Robotic Surgery: The Tonsillar Fossa Battlefield.

J Craniofac Surg 2020 Apr 16. Epub 2020 Apr 16.

Unit of Otolaryngology, University of Foggia, Foggia.

Introduction: The management of parapharyngeal space (PPS) tumors is surgical, but the approach remains a challenge. Attention should be paid to avoid intra-operative bleeding, cranial nerves damage, and external scars.

Presentation Of Case: The authors report a case of a 23-year-old female, with complaint of progressive, painless swelling just below the right angle of the mandible of 6-month's duration. Read More

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http://dx.doi.org/10.1097/SCS.0000000000006453DOI Listing

Identification of CTNNB1-PLAG1 gene rearrangement in a patient with pulmonary pleomorphic adenoma.

Virchows Arch 2020 Apr 19. Epub 2020 Apr 19.

Department of Human Pathology, Juntendo University Graduate School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.

Pulmonary pleomorphic adenoma (PA) is a rare salivary gland-type neoplasm, which predominantly occurs in the proximal airway. Rearrangement of the pleomorphic adenoma gene 1 (PLAG1) is the most frequent genetic event in PAs of salivary glands. However, whether pulmonary PA also harbors PLAG1 rearrangement has not been elucidated. Read More

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http://dx.doi.org/10.1007/s00428-020-02810-yDOI Listing

Surgical approach to parotid pleomorphic adenoma: a 15-year retrospective cohort study.

Br J Oral Maxillofac Surg 2020 Apr 16. Epub 2020 Apr 16.

Department of Experimental and Clinical Medicine, Unit of Oral and Maxillofacial Surgery (Chairman: Prof.ssa M.G. Cristofaro) - "Magna Graecia" University, Viale Europa, 88100 Catanzaro, Italy. Electronic address:

Our aim was to investigate the clinical outcomes (recurrences, duration of follow-up, and effectiveness) after extracapsular dissection and superficial parotidectomy for pleomorphic adenoma of the parotid gland. We retrospectively studied 261 patients whose adenomas were treated at the Maxillofacial Unit of Magna Graecia University of Catanzaro between January 2003 and December 2015 and had been followed up for at least three years after either extracapsular dissection or superficial parotidectomy. The difference in recurrences and complications between the two techniques were measured by univariate analysis (Fisher's exact test). Read More

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http://dx.doi.org/10.1016/j.bjoms.2020.03.020DOI Listing

Improving the diagnosis of common parotid tumors via the combination of CT image biomarkers and clinical parameters.

BMC Med Imaging 2020 Apr 15;20(1):38. Epub 2020 Apr 15.

Department of Radiology, Chongqing General Hospital, University of Chinese Academy of Sciences, No.104 Pipashan Main St, Yuzhong District, Chongqing, 400014, China.

Background: Our study aims to develop and validate diagnostic models of the common parotid tumors based on whole-volume CT textural image biomarkers (IBMs) in combination with clinical parameters at a single institution.

Methods: The study cohort was composed of 51 pleomorphic adenoma (PA) patients and 42 Warthin tumor (WT) patients. Clinical parameters and conventional image features were scored retrospectively and textural IBMs were extracted from CT images of arterial phase. Read More

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http://dx.doi.org/10.1186/s12880-020-00442-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7161241PMC

Malignant Mixed Tumor (Carcinoma Ex Pleomorphic Adenoma) of the Lacrimal Gland.

Ophthalmic Plast Reconstr Surg 2020 Apr 8. Epub 2020 Apr 8.

Orbital Oncology & Ophthalmic Plastic Surgery, Department of Plastic Surgery.

Purpose: To review the clinical presentation, treatment, and prognosis of patients with malignant mixed tumor (carcinoma ex pleomorphic adenoma) of the lacrimal gland.

Methods: Clinical records and radiographic images were reviewed for patients with malignant mixed tumor of the lacrimal gland treated at the center during 2008-2019.

Results: The study included 9 patients (6 men, 3 women) aged 17-66 years (median age, 56 years). Read More

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http://dx.doi.org/10.1097/IOP.0000000000001625DOI Listing

Prognostic Impact of PD-L1 Expression in Malignant Salivary Gland Tumors as Assessed by Established Scoring Criteria: Tumor Proportion Score (TPS), Combined Positivity Score (CPS), and Immune Cell (IC) Infiltrate.

Cancers (Basel) 2020 Apr 3;12(4). Epub 2020 Apr 3.

Institute of Pathology and Molecular Pathology, Bundeswehrkrankenhaus Ulm, Oberer Eselsberg 40, 89081 Ulm, Germany.

Background: Malignant neoplasms of the salivary glands are rare, and therapeutic options are limited. Results from recently published studies indicate a possible use for checkpoint inhibition in a subset of patients, but there are no established criteria for programme cell death ligand 1 (PD-L1) scoring in salivary gland carcinomas (SGCs).

Methods: In this retrospective study, we present a cohort of 94 SGC patients with full clinical follow-up. Read More

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http://dx.doi.org/10.3390/cancers12040873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226358PMC

Secondary Hyperthyroidism due to an Ectopic Thyrotropin-Secreting Neuroendocrine Pituitary Tumor: A Case Report.

Eur Thyroid J 2020 Feb 21;9(2):106-112. Epub 2020 Jan 21.

Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.

Introduction: The main differential diagnoses of secondary hyperthyroidism include thyrotropin-secreting neuroendocrine pituitary tumors (TSH-PitNETs) and resistance to thyroid hormone. As a rare cause of secondary hyperthyroidism, ectopic thyrotropin-producing neuroendocrine pituitary tumors must also be considered.

Case Presentation: A 48-year-old female patient with overt hyperthyroidism and elevated thyrotropin was admitted to the endocrine outpatient clinic of a secondary care hospital in March 2018. Read More

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http://dx.doi.org/10.1159/000505020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109380PMC
February 2020

Perfusion Computed Tomography Scan Imaging in Differentiation of Benign from Malignant Parotid Lesions.

Int Arch Otorhinolaryngol 2020 Apr 4;24(2):e160-e169. Epub 2019 Nov 4.

Department of Otorhinolaryngology, Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran.

 The most common site of salivary gland tumors is the parotid gland. Computed tomography (CT), magnetic resonance imaging (MRI), and sonography are imaging modalities to differentiate benign from malignant parotid tumors.  The aim of this study is the evaluation of the diagnostic value of perfusion CT for differentiating histological categorization of benign and malignant parotid tumors. Read More

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http://dx.doi.org/10.1055/s-0039-1697005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828566PMC

Quantification of heterogeneity to classify benign parotid tumors: a feasibility study on most frequent histotypes.

Future Oncol 2020 Apr 6;16(12):763-778. Epub 2020 Apr 6.

Diagnostic & Interventional Radiology Service, San Paolo Hospital, Milan, Italy.

To differentiate Warthin tumors (WTs) and pleomorphic adenomas (PAs) measuring heterogeneity of intravoxel incoherent motion (IVIM) and dynamic-contrast enhanced-magnetic resonance imaging biomarkers. Volumes of interest were traced on 18 WT and 18 PA in 25 patients. For each IVIM and dynamic-contrast enhanced biomarker, histogram parameters were calculated and then compared using the Wilcoxon-signed-rank test. Read More

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http://dx.doi.org/10.2217/fon-2019-0736DOI Listing

Roles of Proteoglycans in the Tumourigenesis and Development of Adenoid Cystic Carcinoma and Pleomorphic Adenoma of the Salivary Gland: A Systematic Review.

Chin J Dent Res 2020 ;23(1):11-25

Salivary adenoid cystic carcinoma (ACC) and pleomorphic adenoma (PA) are the most common types of salivary gland tumours; the former is malignant and the latter is benign but with features of a border tumour. Proteoglycans (PGs) produced by neoplastic myoepithelial cells are ubiquitous in both types of tumours. However, normal myoepithelial cells of salivary glands do not have the ability to secrete PGs. Read More

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http://dx.doi.org/10.3290/j.cjdr.a44332DOI Listing

Ectopic Lacrimal Gland Tissue: A Systematic Review.

Ophthalmic Plast Reconstr Surg 2020 Mar 19. Epub 2020 Mar 19.

Queen Victoria Hospital, East Grinstead, United Kingdom.

Purpose: To review the clinical and histopathological findings associated with ectopic lacrimal gland tissue.

Methods: A systematic review of the literature on ectopic lacrimal gland tissue was performed. Studies which met clinical and histolopathological criteria for ectopic lacrimal gland tissue written in English and published in peer-reviewed journals were included. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001621DOI Listing

[Role of overexpression of myeloid cell leukemia-1-long in prognosis of malignant pleomorphic adenoma].

Zhonghua Kou Qiang Yi Xue Za Zhi 2020 Mar;55(3):153-158

Department of Oral and Maxillofacial Surgery, College of Stomatology, North China University of Science and Technology, Tangshan 063000, China.

To evaluate the clinicopathological significance of the expression of the two myeloid cell leukemia-1 isoforms, myeloid cell leukemia-1-long (Mcl-1L) and myeloid cell leukemia-1-short (Mcl-1S) in malignant pleomorphic adenoma (MPA). A total of 56 patients with MPA treated with surgery, the expression of Mcl-1L and Mcl-1S were detected by quantitative real-time PCR (qPCR) in mRNA level, and by Western blotting in protein level, respectively. The correlation between clinicopathological parameters (gender, age, site, habits, size, node, metastasis, recurrence) was done using the -square test. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1002-0098.2020.03.002DOI Listing

A miscellany of cribriform pattern, squamous metaplasia and clear cells in pleomorphic adenoma of upper lip: A diagnostic paradox.

J Oral Maxillofac Pathol 2020 Feb 28;24(Suppl 1):S46-S50. Epub 2020 Feb 28.

Department of Oral and Maxillofacial Pathology, Guru Nanak Institute of Dental Sciences and Research, Kolkata, West Bengal, India.

Pleomorphic Adenoma (PA), a benign neoplasm of glandular origin most commonly involves major salivary glands. It is rare in minor salivary glands such as hard palate, upper lip and buccal mucosa, frequently affecting middle aged females. PA comprises diverse histopathologic features of epithelial, myoepithelial and mesenchymal components. Read More

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http://dx.doi.org/10.4103/jomfp.JOMFP_354_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069151PMC
February 2020

Warthin's tumour seems to be the most common benign neoplasm of the parotid gland in Germany.

Eur Arch Otorhinolaryngol 2020 Jul 18;277(7):2081-2084. Epub 2020 Mar 18.

Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Augsburg, Sauerbruchstraße 6, 86179, Augsburg, Germany.

Purpose: Recent reports indicate an increase in the prevalence of Warthin's tumours (adenolymphoma) with percentages which exceed that of pleomorphic adenomas (PA) in the same registries. The purpose of this study is to analyse a large cohort of benign parotid tumours in relation to various demographic and other patients' characteristics that might affect their incidence.

Methods: A retrospective review of prospective collected data was performed on all patients who have been operated for a parotid mass in the last 5 years. Read More

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http://dx.doi.org/10.1007/s00405-020-05894-zDOI Listing

Natural history of recurrent pleomorphic adenoma: implications on management.

Head Neck 2020 Mar 18. Epub 2020 Mar 18.

Department of Head and Neck Surgery, University College Hospitals, London, UK.

Background: Treating recurrent pleomorphic adenoma (RPA) aims to reduce risk of malignant transformation (MT) while avoiding facial nerve injury. Our objective was to systematically investigate this natural history of RPA and address the current rational for its treatment.

Methods: The follow-up data of two nationwide series of PA was pooled with a focus on risk of MT and analyzed against the literature. Read More

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http://dx.doi.org/10.1002/hed.26137DOI Listing
March 2020
2.641 Impact Factor

Gene and immunohistochemical expression of HIF-1α, GLUT-1, FASN, and adipophilin in carcinoma ex pleomorphic adenoma development.

Oral Dis 2020 Mar 16. Epub 2020 Mar 16.

Pathology Department, Faculty of Medical Sciences/UNICAMP, Campinas, Brazil.

Objective: To analyze the gene and immunohistochemical expression of HIF-1α, GLUT-1, FASN, and adipophilin in normal salivary gland (NSG), pleomorphic adenoma (PA), and carcinoma ex pleomorphic adenoma (CXPA) samples.

Material And Methods: The gene expression was investigated by the real-time PCR (qRT-PCR) method in 9 samples of frozen tissues of normal salivary gland, 13 PA, and 10 CXPA. We validated the reactions by immunohistochemistry on 20 samples from NSG, 85 PA, and 44 CXPA. Read More

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http://dx.doi.org/10.1111/odi.13332DOI Listing

Pleomorphic Adenoma of Tongue: A Case Report.

Indian J Otolaryngol Head Neck Surg 2020 Mar 4;72(1):145-147. Epub 2019 Nov 4.

ENT Department, ESIC Model Hospital, Beltola, Guwahati, Assam India.

Pleomorphic adenoma (PA) of minor salivary glands accounts for less than 3% of all head and neck tumors. It is a benign tumor. Palate is the most common site followed by upper lips. Read More

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http://dx.doi.org/10.1007/s12070-019-01747-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040158PMC

A Rare De Novo Myoepithelial Carcinoma Ex Pleomorphic Adenoma in a Young Woman.

Case Rep Otolaryngol 2020 26;2020:8325374. Epub 2020 Feb 26.

Division of Otolaryngology/Head & Neck Surgery, Howard University College of Medicine, Washington, DC, USA.

Carcinoma ex pleomorphic adenoma, an uncommon neoplasm of the parotid gland, accounts for less than 4% of salivary gland tumors. It arises from a benign pleomorphic adenoma presenting in the sixth to eighth decades of life. We present this as a unique account of a primary parotid gland carcinoma, arising from myoepithelial cells, without a known precursor lesion, in a 28-year-old woman. Read More

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http://dx.doi.org/10.1155/2020/8325374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061126PMC
February 2020