6,663 results match your criteria Pleomorphic Adenoma


Heterogeneity of Genetic Landscapes in Salivary Gland Tumors and Their Critical Roles in Current Management.

Medeni Med J 2022 Jun;37(2):194-202

Department of Otorhinolaryngology-Head & Neck Surgery, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, Malaysia.

Salivary gland neoplasms (SGNs) are rare and heterogeneous tumors in the head and neck region. Although progress has been recently made in revealing the molecular landscape of salivary glands tumors, it is limited and appears to be the tip of the iceberg. Some genetic aberrations include chromosomal translocations, such as CRTC1/3-MAML2 in mucoepidermoid carcinoma, g MYB-NFIB gene fusions in adenoid cystic carcinoma, and PLAG1-HMGA2 gene changes in pleomorphic adenoma and carcinoma ex pleomorphic adenoma. Read More

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Pediatric fibromyxoid tumor with PLAG1 fusion: An emerging entity with a novel intracranial location.

Neuropathology 2022 Jun 20. Epub 2022 Jun 20.

Chulalongkorn GenePRO Center, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Translocations involving PLAG1 occur in several tumors, most commonly pleomorphic adenoma and lipoblastoma. Recently, a distinctive soft tissue tumor with a PLAG1 fusion has been reported in the pediatric age group. These are low grade tumors with a fibroblastic or mixed fibroblastic and myxoid morphology but no other lines of differentiation. Read More

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A retrospective study of parotid gland tumors at a single institution.

Oncol Lett 2022 Jul 13;24(1):207. Epub 2022 May 13.

Department of Otolaryngology-Head and Neck Surgery, Hokuto Hospital, Obihiro, Hokkaido 080-0833, Japan.

The aim of the present study was to analyze the clinical characteristics, surgical treatments and clinical outcome of patients with parotid gland tumors and to compare the results with those cited in the literature. A retrospective study was conducted in 140 patients (male, n=77; female, n=63) with parotid gland tumors who underwent parotidectomy at Hokuto Hospital Department of Otolaryngology-Head and Neck Surgery (Obihiro, Japan) between April 2007 and December 2021. Of the 140 patients enrolled, 118 (84. Read More

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Head and Neck Cystic Lesions: A Cytology Review of Common and Uncommon Entities.

Acta Cytol 2022 Jun 17:1-12. Epub 2022 Jun 17.

Department of Pathology, The Johns Hopkins University School of Medicine and The Johns Hopkins Hospital, Baltimore, Maryland, USA.

Background: Cystic lesions of the head and neck are a diagnostic challenge since they are seen in the clinical presentation of a wide variety of conditions. Herein, common and uncommon entities that present as cystic lesions in the head and neck are reviewed.

Summary: In this study, peer-reviewed articles were selected using the database PubMed, Google, Google Scholar, and Scopus. Read More

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Pleomorphic Adenoma of the Palate: A Rare Case in an Adolescent With Cleft lip and Palate.

Cleft Palate Craniofac J 2022 Jun 14:10556656221102038. Epub 2022 Jun 14.

Division of Plastic and Craniofacial Surgery, Children's Mercy Hospital, Kansas City, MO, USA.

Benign salivary gland tumors are rarely found in children and adolescents compared with adults. Pleomorphic adenomas (PAs), the most common benign salivary gland tumor, account for only 1% of all head and neck lesions and fewer than 5% of all salivary gland tumors in individuals under the age of 16 years. The data on palatal PA in the first 2 decades of life is confined to published case reports and case series. Read More

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[Tyrosine crystals in pleomorphic adenoma of parotid gland].

Ann Pathol 2022 Jun 10. Epub 2022 Jun 10.

Laboratoire de Pathologie, Grand Hôpital de l'Est Francilien, 2-4, cours de la Gondoire, 77600 Jossigny, France. Electronic address:

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Global DNA Methylation Profiling Reveals Differentially Methylated CpGs between Salivary Gland Pleomorphic Adenomas with Distinct Clinical Course.

Int J Mol Sci 2022 May 25;23(11). Epub 2022 May 25.

Institute of Human Genetics, Polish Academy of Sciences, Strzeszynska 32, 60-479 Poznan, Poland.

Pleomorphic adenomas (PAs) are the most frequently diagnosed benign salivary gland tumors. Although the majority of PAs are characterized by slow growth, some develop very fast and are more prone to recur. The reason for such differences remains unidentified. Read More

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Multifocal recurrence of pleomorphic adenoma of the lacrimal gland.

Am J Ophthalmol Case Rep 2022 Sep 27;27:101600. Epub 2022 May 27.

Orbital Oncology & Ophthalmic Plastic Surgery, Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA.

Purpose: To report two cases of multifocal recurrent pleomorphic adenoma of the lacrimal gland, and to highlight the clinical and magnetic resonance imaging findings.

Observations: The authors present two patients with recurrent pleomorphic adenoma of the lacrimal gland. During their previous primary surgical resection at outside institutions, one patient reportedly had a macroscopically complete excision, while the second patient had violation of the pseudocapsule. Read More

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September 2022

Proteomics Study of Mesenchymal Stem Cell-Like Cells Obtained from Tumor Microenvironment of Patients with Malignant and Benign Salivary Gland Tumors.

Cell J 2022 Apr 27;24(4):196-203. Epub 2022 Apr 27.

Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Email:

Objective: Salivary gland tumors (SGTs) show some aggressive and peculiar clinicopathological behaviors that might be related to the components of the tumor microenvironment, especially mesenchymal stem cells (MSCs)-associated proteins. However, the role of MSCs-related proteins in SGTs tumorigenesis is poorly understood. This study aimed to isolate and characterize MSCs from malignant and benign tumor tissues and to identify differentially expressed proteins between these two types of MSCs. Read More

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Diagnosis of an extremely rare case of malignant adenomyoepithelioma in pleomorphic adenoma: A case report.

World J Clin Cases 2022 May;10(14):4648-4653

Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 23000, Anhui Province, China.

Background: Pleomorphic adenoma (PA) is the most common type of salivary gland tumor, and its common sites are parotid gland, sinus, nasal septum and cleft palate. PA is an uncommon benign type of tumor occurring in the breast, and there are few reports of cases in Asia.

Case Summary: An 84-year-old woman found a mass in the upper outer quadrant of the right breast > 1 year ago. Read More

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Pre-styloid parapharyngeal space masses-Tumor margins as a predictor of benign versus malignant histology on pre-operative CT or MRI.

Neuroradiol J 2022 May 31:19714009221089027. Epub 2022 May 31.

Department of Radiology, Section of Neuroradiology, 70083University of California Davis Medical Center, Sacramento, CA, USA.

Purpose: Evaluate the frequency of benign versus malignant masses within the prestyloid parapharyngeal space (PPS) and determine if tumor margins on preoperative cross-sectional imaging can predict malignancy status.

Materials And Methods: The electronic health record at UC Davis Medical Center was searched for PPS masses surgically resected between 2015 and 2021. Cases located centrally within the prestyloid PPS with confirmed histologic diagnosis were included and separated into either benign or malignant groups. Read More

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Endoscopic management of huge pleomorphic adenoma of the nasal septum; a case report.

Ann Med Surg (Lond) 2022 May 29;77:103697. Epub 2022 Apr 29.

Medical Officer, Metrocity Hospital, Pokhara, Nepal.

Introduction: and Importance: Pleomorphic adenoma (PA) is one of the most common benign tumors of the salivary glands. They can develop in all the salivary glands, but it most commonly occurs in the parotid gland, followed minor salivary gland. It may occurs at the hard and soft palate, lips, cheeks, gingiva, and nasal septum. Read More

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Increased MIB-1 expression in salivary gland pleomorphic adenoma that recurs and undergoes malignant transformation.

Sci Rep 2022 May 30;12(1):9029. Epub 2022 May 30.

Department of Pathology, HUSLAB, Helsinki University Hospital and University of Helsinki, PO Box 21, 00014, Helsinki, Finland.

The objective of this retrospective study was to explore possible changes in histopathological features and expression of cyclin D1 and MIB-1 in salivary gland pleomorphic adenoma (PA) that recur or undergo malignant transformation. Knowledge of these characteristics might help to guide the management of these rare tumors. The histopathology and immunohistochemical staining characteristics of such tumors were analyzed in a cohort of 65 patients constituting three different groups of tumors: PA, recurrent pleomorphic adenoma (RPA) and carcinoma ex PA (CxPA). Read More

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Diagnostic Challenges and Pitfalls of Mammary Pleomorphic Adenoma Illustrated by a Case Report.

Int J Surg Pathol 2022 May 29:10668969221102552. Epub 2022 May 29.

Department of Pathology, 46657Gustave Roussy, Villejuif, France.

Mammary pleomorphic adenoma is a biphasic tumor, characterized by epithelial-myoepithelial components with myxochondroid stroma, resembling the prototypic pleomorphic adenoma of the salivary glands. We report the multiple diagnostic pitfalls raised by a mammary pleomorphic adenoma, initially diagnosed as mucinous carcinoma on fine-needle aspiration (FNA) cytology and invasive carcinoma on needle core biopsy. The final diagnosis was made on the surgical specimen. Read More

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Response to Miles Kiernan Re: a rare case of mucoepidermoid carcinoma ex pleomorphic adenoma of the lacrimal gland.

Orbit 2022 May 29. Epub 2022 May 29.

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA.

Our goal is to contribute to the medical literature with our case of CEPA and hope to better help fellow clinicians diagnose and treat these rare tumors. Read More

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Pleomorphic Adenoma of Minor Salivary Gland.

J Coll Physicians Surg Pak 2022 Apr;32(4):S70-S72

Department of Oral and Maxillofacial Surgery, Abbasi Shaheed Hospital; and Karachi Medical and Dental College (KMDC), Karachi, Pakistan.

Pleomorphic adenoma is a benign tumor of salivary glands, arising from minor salivary glands, is very rare and presents with a minor female predilection; and the highest occurrence is between the fourth and sixth decades of life. It is of glandular origin, usually presenting as a slowly growing, painless, firm swelling that does not cause ulceration of the overlying mucosa. In this case, a 27-year male presented with swelling on buccal mucosa for three years. Read More

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Clinical outcomes and cost-effectiveness of superficial parotidectomy versus extracapsular dissection of the parotid gland: a single-centre retrospective study of 161 patients.

Int J Oral Maxillofac Surg 2022 May 24. Epub 2022 May 24.

Department of Oral Health Sciences, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium; Department of Oral and Maxillofacial Surgery, Sint-Elisabeth Hospital, Tilburg, the Netherlands.

Improvements in preoperative diagnostics and intraoperative techniques have made the surgical excision of benign parotid gland tumours less invasive. Extracapsular dissection (ECD) has become more popular in comparison to superficial parotidectomy (SP), the gold standard. Although clinical outcomes have been reported, reports on cost-effectiveness are limited. Read More

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Distribution and Frequency of Salivary Gland Tumours: An International Multicenter Study.

Head Neck Pathol 2022 May 27. Epub 2022 May 27.

Unit of Oral and Maxillofacial Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield, S10 2TA, UK.

Background: Salivary gland tumours (SGT) are a relatively rare group of neoplasms with a wide range of histopathological appearance and clinical features. To date, most of the epidemiological studies on salivary gland tumours are limited for a variety of reason including being out of date, extrapolated from either a single centre or country studies, or investigating either major or minor glands only.

Methods: This study aimed to mitigate these shortcomings by analysing epidemiological data including demographic, anatomical location and histological diagnoses of SGT from multiple centres across the world. Read More

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Pleomorphic Adenoma of the Nasal Septum: A Case Report.

Cureus 2022 Apr 22;14(4):e24400. Epub 2022 Apr 22.

Otolaryngology - Head and Neck Surgery, Hospital Miri, Miri, MYS.

Pleomorphic adenoma is the most common benign tumor of major and minor salivary glands. It rarely originates from the nasal cavity. It is important to identify the symptoms and characteristics of the disease so that early diagnosis can be made and appropriate treatment can be offered as it has a risk of malignant transformation. Read More

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First comprehensive report on distribution of histologically confirmed oral and maxillofacial pathologies; a nine-year retrospective study.

J Pak Med Assoc 2022 Apr;72(4):685-690

Department of General Pathology, Rehman Medical Institute, Peshawar, Pakistan.

Objective: To report the distribution of oral and maxillofacial pathologies diagnosed histologically in laboratory.

Methods: The retrospective descriptive cross-sectional study was conducted at Rehman Medical Institute, Peshawar, Pakistan, and comprised biopsied lesions submitted to the institutional laboratory from 2010 to 2019. Data on gender, age, site of the lesion and histopathological diagnosis was retrieved from the records. Read More

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A highly specific recurrent pleomorphic adenoma of the nasal septum.

Auris Nasus Larynx 2022 May 22. Epub 2022 May 22.

Department of Otolaryngology, Faculty of Medicine, Kagawa University, Kita-gun, Miki-cho, Ikenobe 1750-1, Kagawa 761-0793, Japan.

A 90-year-old woman presented with the sudden onset of visual loss. She previously underwent surgery to treat a right septal pleomorphic adenoma (PA) at 77 years old. She initially presented to our hospital with severe nasal obstruction at 83 years old. Read More

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Deep learning model developed by multiparametric MRI in differential diagnosis of parotid gland tumors.

Eur Arch Otorhinolaryngol 2022 May 21. Epub 2022 May 21.

Department of Radiology, Inonu University Faculty of Medicine, Malatya, Turkey.

Purpose: To create a new artificial intelligence approach based on deep learning (DL) from multiparametric MRI in the differential diagnosis of common parotid tumors.

Methods: Parotid tumors were classified using the InceptionResNetV2 DL model and majority voting approach with MRI images of 123 patients. The study was conducted in three stages. Read More

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Pleomorphic adenoma of the left lacrimal gland recurred and transformed into myoepithelial carcinoma after multiple operations: A case report.

World J Clin Cases 2022 Apr;10(11):3630-3638

Department of Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.

Background: Myoepithelial carcinoma (MC) is a clinically rare malignancy, there is controversy regarding its etiology and its biological behavior is not fully elucidated. Extensive surgical resection is the main treatment method. We describe a case of pleomorphic adenoma (PA) with multiple postoperative recurrences after malignant transformation, and the history of the disease in this patient was more than 20 years. Read More

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Polarized Microscopic Analysis of Picrosirius Red Stained Salivary Gland Pathologies: An Observational Study.

Eur J Dent 2022 May 17. Epub 2022 May 17.

Department of Anatomy, Faculty of Dentistry, Mahidol University, Bangkok, Thailand.

Objective:  Salivary gland diseases and their pathologies may affect the glandular structure including collagen, a major stromal component, in response to tissue damage or diseases. This study aimed to examine the changes in collagens in different salivary gland diseases using polarized picrosirius red staining.

Materials And Methods:  The submandibular gland samples diagnosed as sialadenitis, chronic sclerosing sialadenitis, pleomorphic adenoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma were stained with picrosirius red, Masson's trichrome, and anticollagen I staining. Read More

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A Deep Learning Model for Classification of Parotid Neoplasms Based on Multimodal Magnetic Resonance Image Sequences.

Laryngoscope 2022 May 16. Epub 2022 May 16.

ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.

Objective: To design a deep learning model based on multimodal magnetic resonance image (MRI) sequences for automatic parotid neoplasm classification, and to improve the diagnostic decision-making in clinical settings.

Methods: First, multimodal MRI sequences were collected from 266 patients with parotid neoplasms, and an artificial intelligence (AI)-based deep learning model was designed from scratch, combining the image classification network of Resnet and the Transformer network of Natural language processing. Second, the effectiveness of the deep learning model was improved through the multi-modality fusion of MRI sequences, and the fusion strategy of various MRI sequences was optimized. Read More

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Evaluation of immunohistochemical expression of E-cadherin in pleomorphic adenoma and adenoid cystic carcinoma.

J Oral Maxillofac Pathol 2022 Jan-Mar;26(1):65-71. Epub 2022 Mar 31.

Department of Dentistry, Gayathri Medical College and Hospital, Marikivalasa, Vishakapatnam, Andhra Pradesh, India.

Background: Pleomorphic adenoma (PA) and adenoid cystic carcinoma (ADCC) are benign and malignant salivary gland tumors, respectively, with distinct behavior. They have similar origins and cell components. E-cadherins are the main homophilic cell adhesion molecules, which play a central role in maintaining epithelial integrity, functioning in intercellular adhesion and differentiation. Read More

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Role of HER2 in Prognosis of Salivary Duct Carcinoma: A Systematic Review and Meta-Analysis.

Laryngoscope 2022 May 14. Epub 2022 May 14.

Department of Otolaryngology, Head and Neck Surgery, Southern Illinois University, Springfield, Illinois, U.S.A.

Objectives: Salivary duct carcinoma (SDC) is a rare, aggressive malignancy with a poor prognosis. These tumors frequently stain positive for HER2/ErbB2, but data on the prognostic significance of HER2 status in SDC are mixed. We sought to determine whether HER2 status affects survival outcomes in SDC. Read More

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Risk and Lag-time for Development of Lacrimal Gland Carcinoma Expleomorphic Adenoma: Observations and Conjectural Study.

Ophthalmic Plast Reconstr Surg 2022 May 13. Epub 2022 May 13.

Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.

Aims: To estimate the proportion of de novo lacrimal gland pleomorphic adenomas (PAs) and carcinomas expleomorphic adenomas (CEPAs), together with age at presentation and first symptom. Conjectural models of tumor growth are considered.

Methods: Retrospective review of patients with orbital lobe PA or CEPA. Read More

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Recurrent lacrimal gland pleomorphic adenoma.

Orbit 2022 May 12:1-6. Epub 2022 May 12.

National Ophthalmic Pathology Laboratory, Royal Eye and Ear Hospital, Dublin, Ireland.

Pleomorphic adenoma is the most common tumour of the lacrimal gland. Correct preoperative diagnosis is essential as the tumour should be removed en bloc. Incisional biopsy is contraindicated due to risk of recurrence and subsequent risk of malignancy. Read More

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