6,412 results match your criteria Pleomorphic Adenoma


Degenerative nuclear atypia in pleomorphic adenoma of salivary glands: Histological and immunohistochemical observations.

Pathol Res Pract 2021 May 13;224:153482. Epub 2021 May 13.

School of Dentistry, Institute of Life Course and Medical Sciences | Faculty of Health & Life Sciences, University of Liverpool, Liverpool, United Kingdom; Department of Pathology, Liverpool Clinical Laboratories, Liverpool, United Kingdom. Electronic address:

The occurrence and topographical distribution of nuclear changes regarded as degenerative were examined in 84 salivary pleomorphic adenomas (PAs). Haematoxylin and eosin-stained sections from them were light-microscopically studied for unusual variations in size, shape and chromatin pattern of tumour-cell nuclei. Selected cases were further examined by immunohistochemical techniques valuable in characterising cell phenotypes in PA, and cell cycle antigens. Read More

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Myoepithelial Carcinoma Ex-Pleomorphic Adenoma: A Rare Pathology Misdiagnosed as Pleomorphic Adenoma; With a Novel TERT Promoter Mutation and High PD-L1 Expression.

Head Neck Pathol 2021 Jun 14. Epub 2021 Jun 14.

Department of Pathology, University of New Mexico School of Medicine, University of New Mexico, MSC08 4640, Albuquerque, NM, 87131, USA.

Myoepithelial carcinoma (MECA) is a rare salivary gland (SG) neoplasm (0.1-0.45% of all SG tumors) that often presents with bland cytomorphology and can be misclassified as cellular pleomorphic adenoma (PA) or myoepithelioma. Read More

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Partial superficial parotidectomy for pleomorphic adenoma of the parotid gland.

BMJ Case Rep 2021 Jun 14;14(6). Epub 2021 Jun 14.

Department of Conservative Dentistry and Endodontics, Melaka Manipal Medical College, Bukit Baru, Melaka, Malaysia.

Pleomorphic adenoma, otherwise called as benign mixed tumour, is the most common salivary gland tumour which accounts for 60% of all benign salivary gland tumours. The clinical, radiological and histopathological presentations are varied. The tumour occurs in diverse anatomical sites and can consist of epithelial and mesenchymal components. Read More

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Expressions of CXCL12, CXCL10 and CCL18 in Warthin tumors characterized pathologically by having a lymphoid stroma with germinal centers.

Histol Histopathol 2021 Jun 14:18352. Epub 2021 Jun 14.

Department of Pathology, University of Yamanashi, Chuo, Japan.

The Warthin tumor is a benign neoplasm of the salivary glands, histologically, the tumor has an oncocytic epithelial component forming uniform rows of cells surrounded by cystic spaces associated with a lymphoid stroma often showing the presence of germinal centers. The lymphoid stroma is a representative microscopic finding. If this lymphocytic accumulation is active, some sort of transmitter should exist between the Warthin tumor cells and lymphocytes. Read More

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Nasopharyngeal carcinoma ex-pleomorphic adenoma (noninvasive): A report of a rare case.

J Oral Maxillofac Pathol 2021 Mar 19;25(Suppl 1):S58-S60. Epub 2021 Mar 19.

Department of ENT, Institute of Medical Sciences and SUM Hospital, Bhubaneswar, Odisha, India.

Pleomorphic adenoma (PA) is the most common type of benign tumors of minor salivary glands. A carcinoma ex-pleomorphic adenoma (CXPA) is a malignant epithelial neoplasm originating from either a primary or recurrent benign PA. The nasopharynx is an extremely uncommon location for this tumor. Read More

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Solitary extramedullary plasmacytoma of the parotid gland in a patient with mixed connective tissue disease.

J Oral Maxillofac Pathol 2021 Mar 19;25(Suppl 1):S18-S21. Epub 2021 Mar 19.

Department of Oral and Maxillofacial Surgery, General Hospital George Papanikolaou, Thessaloniki, Greece.

Solitary extramedullary plasmacytomas of the head and neck region are rare entities. Very few have been described in the parotid gland. They can clinically and radiologically mimic the rather common benign tumors of the parotid gland (pleomorphic adenoma and Wharthin's tumor), and subsequently the need careful consideration by the involving surgeon and pathologist is needed for a proper diagnosis. Read More

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Parapharyngeal space pleomorphic adenoma with extensive lipometaplasia - A rare unique pathological entity.

J Oral Maxillofac Pathol 2021 Mar 19;25(Suppl 1):S4-S6. Epub 2021 Mar 19.

Department of Pathology, Christian Medical College, Vellore, Tamil Nadu, India.

Pleomorphic adenoma (PA) is the most common neoplasm of the salivary gland. Fat-containing tumors encountered in salivary glands are very rare. We had a case of PA of parapharyngeal space and surprisingly the final histopathology showed an unusual finding of lipometapasia. Read More

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Differentiation of lacrimal gland tumors using the multi-model MRI: classification and regression tree (CART)-based analysis.

Acta Radiol 2021 May 31:2841851211021039. Epub 2021 May 31.

Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, PR China.

Background: Little is known about the value of dynamic contrast-enhanced (DCE) in combination with diffusion-weighted imaging (DWI) for the differentiation of lacrimal gland tumors.

Purpose: To evaluate the ability of DCE and DWI in differentiating lacrimal gland tumors.

Material And Methods: DCE and DWI were performed in 72 patients with lacrimal gland tumors. Read More

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Sarcomatoid urothelial carcinoma arising in the female urethral diverticulum.

Authors:
Heae Surng Park

J Pathol Transl Med 2021 Jun 1. Epub 2021 Jun 1.

Department of Pathology, Ewha Womans University Seoul Hospital, Seoul, Korea.

A sarcomatoid variant of urothelial carcinoma in the female urethral diverticulum has not been reported previously. A 66-year-old woman suffering from dysuria presented with a huge urethral mass invading the urinary bladder and vagina. Histopathological examination of the resected specimen revealed predominantly undifferentiated pleomorphic sarcoma with sclerosis. Read More

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Endoscopic Resection of a Massive Pleomorphic Adenoma of the Nasal Septum.

Ear Nose Throat J 2021 May 31:1455613211020972. Epub 2021 May 31.

Department of Otolaryngology-Head and Neck Surgery, Asahikawa Medical University, Asahikawa, Japan.

Pleomorphic adenoma is a benign tumor that commonly arises from the major salivary glands, such as the parotid and submandibular glands. However, they rarely originate from the nasal cavity. Herein, we describe the case of a 49-year-old woman who presented with nasal obstruction. Read More

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Transnasal Endoscopic Resection of Torus Tubarius Pleomorphic Adenoma.

Ear Nose Throat J 2021 May 31:1455613211014113. Epub 2021 May 31.

2nd Academic ORL, Head and Neck Surgery Department, Aristotle University of Thessaloniki, Papageorgiou Hospital, Thessaloniki, Greece.

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Pediatric Pleomorphic Adenoma of the Palate.

Case Rep Dent 2021 17;2021:9938672. Epub 2021 May 17.

Department of Oral and Maxillofacial Surgery, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam and Department of Head and Neck Surgery, Antoni van Leeuwenhoek Hospital, Amsterdam, Netherlands.

Pleomorphic adenoma is the most common salivary gland tumor but is extremely rare in pediatric patients. The parotid gland is the most affected salivary gland, and the minor salivary glands are rarely affected. Here, we report a case of a 12-year-old boy with a pleomorphic adenoma of the palate. Read More

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Cytopathology of solitary fibrous tumor: a series of 34 cases.

J Am Soc Cytopathol 2021 May 6. Epub 2021 May 6.

Department of Pathology, Tata Memorial Hospital, Homi Bhabha National Institute University, Mumbai, Maharashtra, India.

Introduction: Solitary fibrous tumor (SFT), a fibroblastic neoplasm characterized by a specific genetic alteration (NAB2-STAT6 fusion) and relatively specific immunohistochemical profile (STAT6/CD34 positivity), is seldom the subject of cytopathology data. We report our experience with scrape smears and fine-needle aspiration (FNA) biopsies of SFT in a large patient cohort.

Materials And Methods: A search was made of our cytopathology and surgical pathology databases for cases diagnosed as solitary fibrous tumor (SFT). Read More

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2-Methoxyestradiol synergizes with Erlotinib to suppress hepatocellular carcinoma by disrupting the PLAGL2-EGFR-HIF-1/2α signaling loop.

Pharmacol Res 2021 Jul 20;169:105685. Epub 2021 May 20.

Center for New Drug Safety Evaluation and Research, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, China. Electronic address:

Erlotinib, an EGFR tyrosine kinase inhibitor has been introduced into cancer chemotherapy. However, the therapeutic effects of erlotinib in hepatocellular carcinoma (HCC) remain vaguely understood. Our previous study found that a hypoxia-mediated PLAGL2-EGFR-HIF-1/2α signaling loop in HCC decreased response to erlotinib. Read More

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Synchronous pleomorphic adenoma in the infratemporal fossa and contralateral submandibular gland and endoscopic removal.

BMJ Case Rep 2021 May 21;14(5). Epub 2021 May 21.

Department of ENT and Head and Neck Surgery, Apollo Specialty Cancer Hospital, Chennai, Tamil Nadu, India.

The objective of this article is to elucidate on our experience with the first case reported in the literature of a synchronous presentation of pleomorphic adenoma (PA) in infratemporal fossa as well as the contralateral submandibular gland. PA most commonly arises from the major salivary glands but has also been reported to arise from minor salivary glands in unusual sites such as the nasal septum, main stem bronchus, trachea, lacrimal gland, external auditory canal, etc. However, it seldom involves the infratemporal fossa and extremely few cases are reported in the literature and coexistent contralateral synchronous PA is nowhere reported in literature. Read More

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Colossal Parotid Tumors: A Diagnostic and Surgical Challenge.

Cureus 2021 Apr 18;13(4):e14539. Epub 2021 Apr 18.

Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, IND.

Tumors of the salivary glands constitute 3% of all head and neck tumors. The parotid gland (PG) is the most common site involved in 85% of cases. PG tumors' size varies from a few millimeters to several centimeters and is about 2-6 cm on average. Read More

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Conventional, diffusion, and dynamic contrast-enhanced MRI findings for differentiating metaplastic Warthin's tumor of the parotid gland.

Sci Prog 2021 Apr-Jun;104(2):368504211018583

Department of Radiology, The Affiliated Changshu Hospital of Xuzhou Medical University, Changshu, Jiangsu, China.

The purpose of this study was to explore conventional, diffusion, and dynamic contrast-enhanced MRI (DCE-MRI) characteristics for differentiating metaplastic Warthin's tumor (MWT) from other tumor types of the parotid gland, including non-metaplastic Warthin's tumor (non-MWT), pleomorphic adenoma (PA), and malignant tumor (MT). A total of 178 patients with histologically proven tumors of the parotid gland, including 21 MWTs, 49 non-MWTs, 66 PAs, and 42 MTs, were enrolled in the study. Conventional MRI was performed in all patients. Read More

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Risk Factors of Postoperative Facial Palsy for Benign Parotid Tumors: Outcome of 1,018 Patients.

Laryngoscope 2021 May 18. Epub 2021 May 18.

Institutional Research Office, Osaka Medical College, Takatsuki, Osaka, Japan.

Objective: The aim of this study was to evaluate the rate of postoperative facial palsy in benign parotid tumors, as well as its risk factors, pathology, and clinical results.

Study Design: Retrospective analysis.

Methods: We performed a retrospective analysis of data from patients whose initial operation for a benign parotid tumor had been performed in our department between 1999 and 2020. Read More

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Intraductal carcinoma of the salivary gland with NCOA4-RET: expanding the morphologic spectrum and an algorithmic diagnostic approach.

Hum Pathol 2021 May 12;114:74-89. Epub 2021 May 12.

Pathology Service, Massachusetts General Hospital, 02114 USA; Department of Otolaryngology, Massachusetts Eye and Ear, 02114 USA; Department of Pathology, Harvard Medical School, Boston, MA, 02115 USA. Electronic address:

After the publication of the 2017 World Health Organization Classification of Head and Neck Tumours, there has been increasing interest in the classification of newly categorized intraductal carcinomas. Intraductal carcinoma (IC) is an indolent tumor, typically arising in the parotid gland, with an intact myoepithelial layer and a cystic, papillary, often cribriform architecture. Early studies of IC identified a heterogeneous group of molecular alterations driving neoplasia, and recent studies have defined three primary morphological/immunohistochemical variants, subsequently linking these morphologic variants with defined molecular signatures. Read More

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Role of positron emission tomography in primary carcinoma ex pleomorphic adenoma of the bronchus: A case report.

World J Clin Cases 2021 Apr;9(12):2811-2815

Division of Thoracic Surgery, Department of Surgery, Tri-Service General Hospital, Taipei 114, Taiwan.

Background: Primary carcinoma ex pleomorphic adenoma arising from the tracheobronchial system is rarely reported.

Case Summary: We present a patient with primary carcinoma ex pleomorphic adenoma of the bronchus and review the associated literature for further comparison, including age, clinical manifestations, and diagnostic process. This patient had no history of neoplasms of the salivary gland. Read More

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Immunohistochemical expression of podoplanin as a myoepithelial cell marker in pleomorphic adenoma.

J Oral Maxillofac Pathol 2020 Sep-Dec;24(3):579. Epub 2021 Jan 9.

Department of Oral Pathology and Microbiology and Dr. D. Y. Patil Dental College and Hospital, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India.

Purpose: Pleomorphic adenoma (PA) is the most common benign salivary gland tumor with salivary gland excision as the treatment of choice; however, recurrences after parotidectomy have been reported. The current study is aimed at evaluating podoplanin expression in PA as a myoepithelial (ME) cell marker and its role in estimating the prognosis and outcome of the tumors by correlating it with various clinical and histological parameters.

Materials And Methods: A total of 10 paraffin-embedded specimens of histologically diagnosed PA with clinical records of the patients were retrieved and the slides were then stained using hematoxylin and eosin staining and were then immunohistochemically stained with podoplanin. Read More

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January 2021

Rare histologic presentation of pleomorphic adenoma: A diagnostic dilemma.

J Oral Maxillofac Pathol 2020 Sep-Dec;24(3):563-567. Epub 2021 Jan 9.

Department of Oral and Maxillofacial Pathology and Oral Microbiology, Thai Moogambigai Dental College and Hospital, Dr. MGR Educational and Research Institute University, Chennai, Tamil Nadu, India.

Pleomorphic adenoma is the most common benign salivary gland tumor deriving its name from varied morphological patterns in histopathology. The presence of chondromyxoid stroma in histopathology is characteristic of pleomorphic adenoma. Cellular variants without characteristic chondromyxoid stroma are rare and often pose a diagnostic challenge. Read More

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January 2021

Development and validation of an MRI-based radiomics nomogram for distinguishing Warthin's tumour from pleomorphic adenomas of the parotid gland.

Dentomaxillofac Radiol 2021 May 5:20210023. Epub 2021 May 5.

Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, China.

Objective:: Preoperative differentiation between parotid Warthin's tumor (WT) and pleomorphic adenoma (PMA) is crucial for treatment decisions. The purpose of this study was to establish and validate an MRI-based radiomics nomogram for preoperative differentiation between WT and PMA.

Methods And Materials: A total of 127 patients with histological diagnosis of WT or PMA from two clinical centres were enrolled in training set ( = 75; WT = 34, PMA = 41) and external test set ( = 52; WT = 24, PMA = 28). Read More

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Expression of p16 protein in pleomorphic adenoma and carcinoma ex pleomorphic adenoma proves diversity of tumour biology and predicts clinical course.

J Clin Pathol 2021 May 3. Epub 2021 May 3.

Department of Otolaryngology and Laryngological Oncology, Poznan University of Medical Sciences, Poznan, Poland.

Aims: The aim of the study is to correlate p16 expression with the clinical courses of pleomorphic adenoma (PA), its malignant transformation (CaexPA) and treatment outcomes.

Methods: Retrospective analysis (1998-2019) of 47 CaexPA, 148 PA and 22 normal salivary gland samples was performed. PAs were divided into two subsets: clinically 'slow' tumours characterised by stable size or slow growth; and 'fast' tumours with rapid growth rate. Read More

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Free flap transfer, a safe and efficient method for reconstruction of composite skull base defects after salvage resection of advanced intra- and extracranial communicating tumors: Short title Free flap transfer for reconstruction of composite skull base defects.

World Neurosurg 2021 Apr 30. Epub 2021 Apr 30.

Department of Neurosurgery, National Cancer Center/ National Clinical Research Center for Cancer/ Cancer Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100021, China. Electronic address:

Object: Surgical treatment of advanced intra- and extracranial communicating skull base tumors is challenging, especially for the reconstruction of the large composite defect left by tumor resection. The aim of the study is to evaluate the utility of the free flap reconstruction of the defects resulting from radical resection of these tumors in a single institution.

Methods: The clinical data of 17 consecutive patients who underwent free flap reconstruction for defect left by salvage resection of advanced intra- and extracranial communicating tumors from 2013 to 2019 were retrospectively collected and analyzed. Read More

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Identification and characterization of primary cilia-positive salivary gland tumours exhibiting basaloid/myoepithelial differentiation.

J Pathol 2021 Apr 30. Epub 2021 Apr 30.

Department of Tumor Pathology, Hamamatsu University School of Medicine, Hamamatsu, Japan.

Primary cilia (PC) are non-motile, antenna-like structures on the cell surface. Many types of neoplasms exhibit PC loss, whereas in some neoplasms PC are retained and involved in tumourigenesis. To elucidate the PC status and characteristics of major salivary gland tumours (SGTs), we examined 100 major SGTs encompassing eight histopathological types by immunohistochemical analysis. Read More

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Complete resection of a huge parapharyngeal lesion without neurovascular injuries poses a big challenge.

J Surg Case Rep 2021 Apr 22;2021(4):rjab134. Epub 2021 Apr 22.

Faculty of Medicine, Tishreen University, Lattakia, Syria.

Pleomorphic adenoma is the most common salivary gland neoplasm, accounting for 63% of all parotid gland tumors. Most tumors originate in the superficial lobe but, more rarely, these tumors may involve the deep lobe of the parotid gland, growing medially and occupying the parapharyngeal space (PPS). Our case presents a 48-year-old man with an extremely huge recurrent parapharyngeal lesion that bulging in the nasopharynx and the oropharynx and significantly comprised the airways. Read More

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Epidemiology of Primary Epithelial Salivary Gland Tumors in Southern Poland-A 26-Year, Clinicopathologic, Retrospective Analysis.

J Clin Med 2021 Apr 13;10(8). Epub 2021 Apr 13.

Department of Cranio-Maxillofacial Surgery, Jagiellonian University Medical College, 31-008 Cracow, Poland.

(1) Background: Epidemiological studies of epithelial salivary gland neoplasms are difficult to conduct effectively due to tumor rarity, histological heterogeneity, tumor location diversity, and a lack of national registries collecting data. This study presents 26 years of epidemiological data from a single institution in southern Poland that estimates incidence rates of primary epithelial salivary gland tumors. (2) Methods: The charts of 805 patients with epithelial salivary gland tumors were retrospectively reviewed. Read More

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Pleomorphic adenoma of hard palate: a case report.

Pan Afr Med J 2021 9;38:146. Epub 2021 Feb 9.

Département d´Odontologie Chirurgicale, Faculté de Médecine Dentaire de Rabat, Université Mohammed V, Rabat, Maroc.

Pleomorphic adenoma is a benign mixed tumor, which is composed of myoepithelial and epithelial cells. A fibrous capsule separates these cells from the surrounding tissues. Pleomorphic adenoma is the most common salivary gland tumour accounting for 40-70% of all major and minor salivary gland tumours. Read More

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Pan-TRK Immunohistochemistry Is Highly Correlated With NTRK3 Gene Rearrangements in Salivary Gland Tumors.

Am J Surg Pathol 2021 Apr 23. Epub 2021 Apr 23.

Department of Pathology, Centre Henri Becquerel INSERM 1245, Rouen Normandy Uniiversity Department of Pathology, Rouen University Hospital, Rouen Platform of Experimental Pathology, Department of Diagnostic and Theranostic Medicine, Curie Institute Department of Pathology, Lariboisière Hospital, Paris, France.

Aims: Secretory carcinoma (SC) is characterized by ETV6 rearrangements, most often ETV6-NTRK3 fusion. Given its histologic overlap with other salivary gland tumors (SGTs), SCs can be difficult to diagnose without genetic confirmation. A recently developed pan-TRK (tropomyosin receptor kinase) antibody shows promise for identifying tumors with NTRK (neurotrophic tyrosine kinase receptor 3) fusions. Read More

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