5,973 results match your criteria Pleomorphic Adenoma


CD73 a novel marker for the diagnosis of benign and malignant salivary gland tumors.

J Clin Exp Dent 2019 Mar 1;11(3):e213-e218. Epub 2019 Mar 1.

Undergraduate Student, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Ecto-5'-nucleotidase (CD73) plays an important role in the development of several types of cancer; however, its prognostic significance in salivary gland tumors remains unknown. The current study was conducted to investigate the expression of CD73 in such tumors.

Material And Methods: In this retrospective study, immunohistochemical expression of CD73 was evaluated in 25 pleomorphic adenomas, 20 mucoepidermoid carcinomas and 20 adenoid cystic carcinomas using the Envision technique. Read More

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http://dx.doi.org/10.4317/jced.54918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461735PMC

[Benign Neoplasms of the Orbit].

Klin Monbl Augenheilkd 2019 Apr 18. Epub 2019 Apr 18.

Benign orbital neoplasms comprise a wide spectrum of different entities. The origin of the tumours can be epithelial or mesenchymal. Epithelial neoplasms of the orbit originate from the lacrimal gland. Read More

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http://dx.doi.org/10.1055/a-0885-2402DOI Listing

Diagnostic Significance of HRAS Mutations in Epithelial-Myoepithelial Carcinomas Exhibiting a Broad Histopathologic Spectrum.

Am J Surg Pathol 2019 Apr 15. Epub 2019 Apr 15.

Departments of.

Epithelial-myoepithelial carcinoma (EMC) is a rare salivary gland tumor that is histologically characterized by biphasic tubular structures composed of inner ductal and outer clear myoepithelial cells. Because of its histologic variety, it is sometimes challenging to make an accurate diagnosis, and useful ancillary tests are essential for this purpose. We investigated 87 cases of EMC arising in the major and minor salivary glands and seromucinous glands in the nasal cavity or bronchus to describe the histologic features and mutation status of selected key oncogenes. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001258DOI Listing
April 2019
1 Read

Feasibility of Transoral Approach to Accessory Parotid Tumors.

Cureus 2019 Feb 4;11(2):e4003. Epub 2019 Feb 4.

Otolaryngology, Christian Medical College Hospital, Vellore, IND.

Tumors of the accessory parotid gland are very rare. Surgical removal of an accessory parotid tumor is usually accomplished by superficial parotidectomy through an external neck incision. However, this procedure inevitably results in a neck scar. Read More

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https://www.cureus.com/articles/17141-feasibility-of-transor
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http://dx.doi.org/10.7759/cureus.4003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447140PMC
February 2019
2 Reads

Pleomorphic Adenoma of the Trachea.

Ear Nose Throat J 2019 Apr 15:145561319840189. Epub 2019 Apr 15.

2 Department of Otolaryngology-Head and Neck Surgery, University of Virginia Health System, Charlottesville, VA, USA.

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http://dx.doi.org/10.1177/0145561319840189DOI Listing
April 2019
1 Read

Anti-N-Methyl-D-Aspartate Receptor Encephalitis in a Patient With Antithyroid Peroxidase Antibodies and a Parotid Pleomorphic Adenoma.

Ochsner J 2019 ;19(1):59-62

The University of Queensland Faculty of Medicine, Ochsner Clinical School, New Orleans, LA.

Anti-N-methyl-D-aspartate receptor (NMDA-R) encephalitis is an autoimmune disorder first described in 2007. It can cause severe neurologic and psychiatric symptoms, and patients often are misdiagnosed with a primary psychiatric disorder. Anti-NMDA-R encephalitis is an important differential diagnosis of psychosis, as the condition can be treated with the appropriate therapy. Read More

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http://www.ochsnerjournal.org/lookup/doi/10.31486/toj.18.011
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http://dx.doi.org/10.31486/toj.18.0115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447211PMC
January 2019
6 Reads

Schwannoma-Like Pleomorphic Adenoma: Two Cases and a Review of the Literature.

Head Neck Pathol 2019 Apr 9. Epub 2019 Apr 9.

Department of Pathology and Laboratory Medicine, North Shore University Hospital and Long Island Jewish Medical Center, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Health, New Hyde Park, NY, USA.

Schwannoma-like pleomorphic adenoma is a rare variant of the common benign salivary neoplasm, pleomorphic adenoma. This entity's cytomorphology closely mimics a schwannoma, potentially making a diagnosis of cytologic preparations or of surgical specimens a challenge. To the best of our knowledge, there are only six previous reports of schwannoma-like pleomorphic adenoma with eight total cases in the English language literature prior to the addition of the two cases detailed in this report. Read More

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http://dx.doi.org/10.1007/s12105-019-01036-yDOI Listing
April 2019
3 Reads

Effective chemotherapy for submandibular gland carcinoma ex pleomorphic adenoma with lung metastasis after radiotherapy: A case report.

World J Clin Cases 2019 Mar;7(6):792-797

Department of Head & Neck Cancer, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.

Background: Only a few cases of carcinoma ex pleomorphic adenoma arising in the submandibular gland have ever been reported, all with a poor prognosis. The standard treatment for salivary gland carcinoma ex pleomorphic adenoma is surgical resection combined with postoperative radiotherapy, but the necessity of chemotherapy as well as the most appropriate treatment regimen for patients with distant metastasis after radiotherapy remains controversial.

Case Summary: This report presents the case of a 73-year-old woman who suffered submandibular gland carcinoma ex pleomorphic adenoma. Read More

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http://dx.doi.org/10.12998/wjcc.v7.i6.792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448082PMC
March 2019
1 Read

The repertoire of genetic alterations in salivary duct carcinoma including a novel HNRNPH3-ALK rearrangement.

Hum Pathol 2019 Apr 1. Epub 2019 Apr 1.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Salivary duct carcinoma (SDC) is a rare, aggressive malignancy with limited treatment options and poor outcome. Twenty-nine primary resected SDC, including 15 SDC de novo (SDCDN), and 14 SDC ex pleomorphic adenoma (SDCXPA) were subjected to the massive parallel sequencing assay (MSK-IMPACT™) targeting 287-468 cancer-related genes. TP53 was the most frequently altered gene (69%). Read More

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http://dx.doi.org/10.1016/j.humpath.2019.03.004DOI Listing
April 2019
3 Reads

Coblator-Assisted Endoscopic Transnasal Resection of a Large Nasopharyngeal Pleomorphic Adenoma.

Case Rep Otolaryngol 2019 27;2019:4654357. Epub 2019 Feb 27.

Royal Blackburn Teaching Hospital, Blackburn, UK.

Background: Pleomorphic adenomas occurring in the adult nasopharynx are rare, with our literature search identifying only 11 previous English-language reports. We document the unusual case of a large nasopharyngeal pleomorphic adenoma that was resected using radiofrequency coblation via an endoscopic transnasal approach.

Methods: A 39-year-old male presented with worsening nasal congestion, intermittent otalgia, and a progressive change in voice. Read More

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http://dx.doi.org/10.1155/2019/4654357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415314PMC
February 2019
3 Reads

Genome-wide association study identifies the PLAG1-OXR1 region on BTA14 for carcass meat yield in cattle.

Physiol Genomics 2019 Mar 29. Epub 2019 Mar 29.

Laboratory of Molecular Biology and Bovine Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, China, China.

Carcass meat yield is an important carcass trait that contributes to the production efficiency and economic benefits in beef cattle. It is therefore critical to identify QTLs associated with carcass traits to enable selection. Our previous studies have identified several causal variants within the pleomorphic adenoma gene 1 ( PLAG1) and coiled-coil-helix-coiled-coil-helix domain containing 7 ( CHCHD7) genes on BTA14 for carcass traits in Chinese Simmental. Read More

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http://dx.doi.org/10.1152/physiolgenomics.00112.2018DOI Listing
March 2019
5 Reads

Diagnostic Accuracy of Multiparametric Magnetic Resonance Imaging for Differentiation Between Parotid Neoplasms.

Can Assoc Radiol J 2019 Mar 25. Epub 2019 Mar 25.

Departments of Diagnostic and Interventional Radiology, Mansoura University, Dakahlia, Egypt.

Purpose: This study was designed to evaluate the role of multiparametric magnetic resonance imaging (MRI) for differentiation of parotid gland neoplasms.

Methods: Prospective study was conducted upon 52 consecutive patients (30 men, 22 women; aged 24-78 years; mean, 51 years) with parotid tumours that underwent multiparametric MRI using combined static MRI, dynamic contrast enhanced (DCE) MRI, and diffusion-weighted imaging (DWI). The static MRI parameter, time signal intensity curves (TIC) derived from DCE-MRI, and apparent diffusion coefficient (ADC) values of parotid tumours were correlated with histopathological findings. Read More

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http://dx.doi.org/10.1016/j.carj.2018.10.010DOI Listing
March 2019
1 Read

Recurrent benign pleomorphic adenoma of the parotid gland: Facial nerve identification and risk factors for facial nerve paralysis at re-operation.

Auris Nasus Larynx 2019 Mar 25. Epub 2019 Mar 25.

Department of Pathology, Osaka Medical College, Takatsuki, Osaka, Japan.

Objective: Surgery for recurrent pleomorphic adenoma of the parotid gland is challenging since there is a considerable risk of facial nerve injury and a high re-recurrence rate. We investigated surgery for recurrent pleomorphic adenoma, focusing on management of the facial nerve.

Methods: We reviewed 29 patients who underwent surgery for recurrent benign pleomorphic adenoma of the parotid gland at our department between 1999 and 2018. Read More

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http://dx.doi.org/10.1016/j.anl.2019.02.010DOI Listing
March 2019
1 Read

Involvement of PLAGL1/ZAC1 in hypocretin/orexin transcription.

Int J Mol Med 2019 May 20;43(5):2164-2176. Epub 2019 Mar 20.

Department of Anatomy and Cell Science, Kansai Medical University, Hirakata, Osaka 573‑1010, Japan.

The hypocretin/orexin neuropeptide system coordinates the regulation of various physiological processes. Our previous study reported that a reduction in the expression of pleomorphic adenoma gene‑like 1 (Plagl1), which encodes a C2H2 zinc‑finger transcription factor, occurs in hypocretin neuron‑ablated transgenic mice, suggesting that PLAGL1 is co‑expressed in hypocretin neurons and regulates hypocretin transcription. The present study examined whether canonical prepro‑hypocretin transcription is functionally modulated by PLAGL1. Read More

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http://dx.doi.org/10.3892/ijmm.2019.4143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445593PMC
May 2019
1 Read

Heterotopic pleomorphic adenoma in the postauricular area.

J Dent Sci 2018 Sep 14;13(3):289-291. Epub 2012 Dec 14.

Department of Oral and Maxillofacial Surgery, Tri-Service General Hospital, Taipei, Taiwan.

Heterotopic salivary gland tissue is salivary tissue located outside the sites generally known to accommodate major and minor salivary glands. Although heterotopic salivary tumors were reported in various regions of the head and neck, they are seldom found in the superio-posterior neck region and can be confused with other neck masses. Herein, we present a rare case of a heterotopic pleomorphic adenoma in the postauricular area and remind clinicians that heterotopic salivary tumors should be in the differential diagnosis of neck masses. Read More

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http://dx.doi.org/10.1016/j.jds.2012.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388807PMC
September 2018
1 Read

Challenges in Minor Salivary Gland Biopsies: A Practical Approach to Problematic Histologic Patterns.

Authors:
Lisa M Rooper

Head Neck Pathol 2019 Mar 18. Epub 2019 Mar 18.

Departments of Pathology and Oncology, The Johns Hopkins Hospital, 401 N. Broadway, Weinberg 2242, Baltimore, MD, 21231-2410, USA.

Evaluation of minor salivary gland biopsy can be fraught with a wide range of problems, including technical limitations due to the small size and distorted nature of tissue received and interpretive difficulties navigating the considerable morphologic and immunohistochemical overlap between widely disparate entities. As such, common pathologic findings can evoke a perplexing differential diagnosis that encompasses malignant, benign, and non-neoplastic processes. This review will present the diagnostic considerations that arise from four histologic patterns that are frequently encountered on minor salivary gland biopsies: squamous differentiation, tubular and cribriform growth, mucin production, and myxoid stroma. Read More

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http://dx.doi.org/10.1007/s12105-019-01010-8DOI Listing
March 2019
2 Reads

Management of accessory parotid gland tumours: 32-year experience from a single institution and review of the literature.

Int J Oral Maxillofac Surg 2019 Mar 9. Epub 2019 Mar 9.

University Hospital Centre 'Sisters of Mercy', University Hospital for Tumors, Department of Radiotherapy and Medical Oncology, Ilica, Zagreb, Croatia.

Accessory parotid gland tumours (APGTs) are very rare. Regarding their anatomical location, an adequate surgical approach is necessary to provide safe resection and satisfactory postoperative results. The aims of this study were to present our tertiary centre experience in surgical treatment and management of APGTs and to review the literature regarding their treatment, particularly in terms of surgical modalities. Read More

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http://dx.doi.org/10.1016/j.ijom.2019.02.014DOI Listing
March 2019
1 Read

Ossified Carcinoma Ex Pleomorphic Adenoma in accessory lobe of parotid gland: Complexity in clinical, imaging and histologic diagnosis and minimally invasive surgery.

Oral Oncol 2019 Mar 7. Epub 2019 Mar 7.

Maxillofacial Surgery Unit, Department of Maxillo-Facial Surgery, University of Naples "Federico II", Naples, Italy. Electronic address:

Carcinoma ex pleomorphic adenoma is not common among malignant salivary tumors and an accessory lobe of parotid gland tumor with a carcinoma ex pleomorphic adenoma histology is even rarer. Management of these tumors include a high index of suspicion, good understanding of the anatomy and a meticulous surgical access. The exceptional localization of an ossified Carcinoma ex Pleomorphic Adenoma in the accessory lobe of the parotid gland, never reported to date in the literature, has prompted us to report this case to stress the challenging difficulties related to clinical and histologic diagnosis and to analyze a minimally invasive intraoral approach. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.03.003DOI Listing
March 2019
1 Read

Prognostic value of programed death ligand-1 and ligand-2 co-expression in salivary gland carcinomas.

Oral Oncol 2019 Mar 1;90:30-37. Epub 2019 Feb 1.

Department of Head and Neck Surgery, National Kyushu Cancer Center, Notame 3-1-1, Minami-ku, Fukuoka 811-1395, Japan. Electronic address:

Objectives: The aim of the present study was to investigate the molecular basis for the use of immune checkpoint inhibitors to treat salivary gland carcinomas (SGC).

Materials And Methods: We examined the clinical and prognostic significance of programed death ligands 1 and 2 (PD-L1 and -L2) expression using immunohistochemistry and in situ hybridization, as well as microsatellite instability (MSI) status using polymerase chain reaction, along with tumor-infiltrating lymphocytes (TILs) in 30 cases of SGC.

Results: The SGC cases studied included adenoid cystic carcinoma (AdCC, 36. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.01.015DOI Listing
March 2019
2 Reads

Serum Levels of Zinc, Copper and Ferritin in Patients with Salivary Gland Tumors

Asian Pac J Cancer Prev 2019 Feb 26;20(2):545-548. Epub 2019 Feb 26.

Oral and Dental Disease Research Center, Department of Oral and Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran. Email:

Background: Variation in serum levels of trace elements including zinc, copper and ferritin has been reported in cancer patients. The aim of this study was to evaluate these trace elements in the patients’ sera with benign and malignant salivary gland tumors (SGTs) and compare them with normal individuals. Methods: In this cross-sectional study, 60 patients with SGTs including 16 pleomorphic adenoma and 44 malignant SGTs, as well as 28 healthy controls, were enrolled. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.2.545DOI Listing
February 2019
3 Reads
1.500 Impact Factor

Misinterpreted Myoepithelial Carcinoma of Salivary Gland: A Challenging and Potentially Significant Pitfall.

Am J Surg Pathol 2019 May;43(5):601-609

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY.

Myoepithelial carcinoma (MECA) is an underrecognized challenging entity with a broad morphologic spectrum. Misinterpreting MECA is not uncommon as distinguishing it from its mimics, especially cellular myoepithelial-rich pleomorphic adenoma (PA), can be difficult. We described 21 histologically challenging cases of MECAs (16 MECA ex-PA and 5 MECA de novo). Read More

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http://dx.doi.org/10.1097/PAS.0000000000001218DOI Listing
May 2019
1 Read

Pleomorphic Adenoma of the Upper Lip: A Case Report.

Saudi J Med Med Sci 2018 Jan-Apr;6(1):32-35. Epub 2017 Dec 14.

Department of Dental and Maxillofacial Surgery, Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria.

Pleomorphic adenoma is the most frequently encountered benign mixed tumor of the minor salivary gland and usually presents in the parotid; however, in the minor salivary gland, it is more common in the palate. Tumors of the minor salivary glands are uncommon, with the most common intraoral site reported being the hard and soft palate owing to the preponderance of minor salivary glands in this region followed by the lips. Pleomorphic adenoma arising from minor salivary glands of the lips tends to occur at an earlier age than it does at other sites. Read More

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http://dx.doi.org/10.4103/sjmms.sjmms_109_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196673PMC
December 2017
1 Read

Necrotizing sialometaplasia can hide the presence of salivary gland tumors: A case series.

Oral Dis 2019 May 5;25(4):1084-1090. Epub 2019 Mar 5.

Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.

Objective: Necrotizing sialometaplasia (NS) is an uncommon benign process which affects minor and, more rarely, major salivary glands. While self-limiting, the condition might be clinically and histologically mistaken for malignancy. Furthermore, NS may accompany neoplasms. Read More

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http://doi.wiley.com/10.1111/odi.13066
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http://dx.doi.org/10.1111/odi.13066DOI Listing
May 2019
16 Reads

Two case reports of synchronous unilateral pleomorphic adenoma and cystadenolymphoma of the parotid gland with literature review.

J Ultrason 2018 ;18(75):369-373

Department of Otorhinolaryngology, Head and Neck Surgery , Klinikum Augsburg, Augsburg , Germany.

Synchronous unilateral tumors in the parotid glands account for less than 5-10% of all salivary gland neoplasms. Mostly these are cystadenolymphomas, but tumors of different histological types can be found as well. In these cases it is often pleomorphic adenoma in combination with cystadenolymphoma. Read More

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http://dx.doi.org/10.15557/JoU.2018.0055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444322PMC
January 2018
1 Read

Transoral robotic surgery for the parapharyngeal space: expanding the transoral corridor.

J Robot Surg 2019 Feb 14. Epub 2019 Feb 14.

Department of Otolaryngology and Head and Neck Surgery, All India Institute of Medical Sciences, Teaching Block, 4th, Floor, New Delhi, 110029, India.

To analyze the feasibility, surgical outcomes and possible risks and complications encountered during transoral robotic surgery (TORS) for approaching parapharyngeal space (PPS) tumours, a retrospective cohort study was conducted. Out of 108 TORS procedures performed, 5 PPS tumours were identified from May 2011- November 2017. This study included 2 retrostyloid (benign nerve sheath tumour) and 3 prestyloid tumours (pleomorphic adenoma), of which one patient had previously undergone a transcervical approach for deep lobe of parotid pleomorphic adenoma. Read More

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http://link.springer.com/10.1007/s11701-019-00932-3
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http://dx.doi.org/10.1007/s11701-019-00932-3DOI Listing
February 2019
5 Reads

Collagenous crystalloids in pleomorphic adenoma of the parotid gland.

Diagn Cytopathol 2019 Feb 12. Epub 2019 Feb 12.

Department of Pathology and Laboratory Medicine, Kansai Medical University, Osaka, Japan.

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http://dx.doi.org/10.1002/dc.24149DOI Listing
February 2019
1 Read

Extracapsular invasion: A potential prognostic marker for Carcinoma ex-pleomorphic adenoma of the salivary glands? A Systematic Review.

J Oral Pathol Med 2019 Feb 13. Epub 2019 Feb 13.

Department of Oral Pathology, Federal University of Rio Grande do Norte, Natal, Brazil.

Background: The aim of the present study was to integrate available data published in the literature on extracapsular invasion in cases of CXPA that correlated findings with the prognosis of analysed patients.

Methods: An electronic search was carried out at the MEDLINE/PubMed, EMBASE and Cochrane Collaboration Library databases. Articles that assessed the relationship between extracapsular invasion and survival of patients diagnosed with CXPA were selected for the systematic review. Read More

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http://dx.doi.org/10.1111/jop.12841DOI Listing
February 2019
1 Read

[Epithelial tumors of salivary glands. Review of 286 pathology reports].

Rev Med Chil 2018 Dec;146(10):1159-1166

Departamento de Anatomía Patológica, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

Background: Epithelial tumors of the salivary glands, including benign tumors and aggressive malignancies with different prognoses, are uncommon.

Aim: To describe the frequency and distribution of salivary gland tumors according to age, gender and anatomical location.

Material And Methods: Review of pathological reports of salivary gland tumors of a Pathology laboratory at a clinical hospital from 2006 to 2016. Read More

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http://dx.doi.org/10.4067/S0034-98872018001001159DOI Listing
December 2018
3 Reads

A case of minor salivary gland sialolithiasis of the upper lip.

Oral Maxillofac Surg 2019 Mar 5;23(1):91-94. Epub 2019 Feb 5.

Department of Oral and Maxillofacial Surgery, Nagoya Ekisaikai Hospital, 4-66 Syounen-cho, Nakagawa-ku, Nagoya, 454-8502, Japan.

Background: Sialolithiasis is the most common disease of the salivary glands. Sialolithiasis usually develops in the major salivary glands, and rarely in the minor salivary glands, with only 2% of all cases of sialolithiasis occurring in the minor salivary glands and sublingual glands. Sialoliths in the minor salivary glands result in few or no clinical symptoms and are seldom identified on imaging. Read More

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http://dx.doi.org/10.1007/s10006-019-00745-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394701PMC
March 2019
2 Reads

Intraductal pseudopodia in pleomorphic adenoma of parotid gland.

Indian J Pathol Microbiol 2019 Jan-Mar;62(1):117-118

Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.

Pleomorphic adenoma is the most common salivary gland tumor. Pseudopodia are finger-like projections extending beyond the tumor capsule, seen in pleomorphic adenoma. If not resected completely, these pseudopodia may increase the risk of recurrence after excision of pleomorphic adenoma. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_307_17DOI Listing
February 2019
3 Reads

Immunohistochemical evaluation of salivary gland tumors differentiation and proliferation by using calponin and telomerase.

Saudi Dent J 2019 Jan 29;31(1):105-114. Epub 2018 Nov 29.

Technical College of Health-Sulaimani Polytechnic University, Iraq.

Background: Salivary gland tumors are a heterogeneous group of lesions with diverse histological features. Hence they are considered as a diagnostic challenge for the pathologist. Myoepithelial cells are considered as a key in the morphogenetic process, with diverse differentiation in various salivary gland tumors. Read More

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http://dx.doi.org/10.1016/j.sdentj.2018.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349947PMC
January 2019
3 Reads

Intraparotid facial nerve schwannomas.

Arch Craniofac Surg 2019 Feb 1;20(1):71-74. Epub 2019 Feb 1.

Department of Plastic and Reconstructive Surgery, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu, Korea.

Schwannoma is a benign tumor rarely found in the head and neck and much less commonly found in the intraparotid facial nerve. It is a slow-growing encapsulated tumor originating from the Schwann cells or axonal nerve sheath. It can occur anywhere along the course of the facial nerve. Read More

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http://dx.doi.org/10.7181/acfs.2018.02250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411519PMC
February 2019
3 Reads

Ectopic pleomorphic adenoma on subcutaneous plane of the cheek.

Arch Craniofac Surg 2019 Feb 1;20(1):55-57. Epub 2019 Feb 1.

Department of Plastic and Reconstructive Surgery, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju, Korea.

Pleomorphic adenoma is the most common benign tumor of the salivary gland. Pleomorphic adenoma occurs most commonly in the parotid gland but it may involve other salivary gland such as submandible or lingual. We report an ectopic pleomorphic adenoma in the subcutaneous layer of the face. Read More

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http://e-acfs.org/journal/view.php?doi=10.7181/acfs.2018.019
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http://dx.doi.org/10.7181/acfs.2018.01949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411524PMC
February 2019
13 Reads

[Clinical analysis and surgical treatment evaluation of 23 cases with primary parapharyngeal space tumors].

Zhonghua Kou Qiang Yi Xue Za Zhi 2019 Feb;54(2):107-111

Department of Oral and Maxillofacial Surgery, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing 210008, China.

To analyze the clinical characters and surgical treatment of primary parapharyngeal space (PPS) tumors. A total of 23 cases of primary PPS tumors which were treated from November 2011 to December 2017 were included for the retrospective analysis in this study. Twenty-three cases of patients with primary PPS tumors were analyzed in this study. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1002-0098.2019.02.006DOI Listing
February 2019
5 Reads

[Hepatic metastasis of a pleomorphic adenoma].

Medicina (B Aires) 2019 ;79(1):64-66

Servicio de Cirugía General, Hospital Alemán, Buenos Aires, Argentina.

Pleomorphic adenoma is the most benign tumor of the salivary glands. It can undergo a malignant transformation to carcinoma and metastasize to distant organs, sometimes it can metastasize as a benign tumor. We present the case of an 82 years old male with hepatic lesion detected by ultrasound in routine urologic follow-up. Read More

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January 2019
12 Reads

Oncocytoma Parotid Gland.

Ann Maxillofac Surg 2018 Jul-Dec;8(2):330-332

Department of ENT, Base Hospital Delhi Cantt, New Delhi, India.

Very few cases of parotid oncocytoma have been reported in literature. Because of its rarity (<1% of salivary gland tumors) and clinical presentation of the tumor, there is a tendency among the clinicians to misdiagnose it as pleomorphic adenoma, hemangioma, or other forms of oncocytosis. Only a histopathological examination can confirm it. Read More

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http://dx.doi.org/10.4103/ams.ams_154_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327801PMC
January 2019
7 Reads

Nasopharyngeal Pleomorphic Adenoma: A Rare Case Report and Review of the Literature.

Case Rep Otolaryngol 2018 31;2018:2481370. Epub 2018 Dec 31.

Istanbul Medeniyet University, Faculty of Medicine, Department of Otorhinolaryngology, Goztepe Training and Research Hospital, Istanbul, Turkey.

Salivary gland tumors are rare among all head and neck tumors. Pleomorphic adenoma (PA) is the most commonly seen subtype, and 85% of the cases are located in the parotid gland. PA may very rarely be seen in minor salivary glands. Read More

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http://dx.doi.org/10.1155/2018/2481370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332957PMC
December 2018
3 Reads

[Surgery of primary tracheal tumours of the salivary gland type].

Rev Mal Respir 2019 Jan 25. Epub 2019 Jan 25.

Service de chirurgie thoracique, CHU Hassan II, BP. 1893, Km 2.200, route de Sidi Harazem, 30000 Fès, Maroc; Faculté de médecine et de pharmacie, université Sidi Mohamed Ben Abdellah, Fès, Maroc.

Introduction: Primary tumours of the trachea are very rare and may develop from the tracheal salivary glands.

Case Reports: We describe four patients operated on in our service between 2010 and 2017 of whom two had an adenocystic carcinoma, one a mucoepidermoid carcinoma and one a pleomorphic adenoma of the trachea. All were treated by resection and tracheal anastomosis with clear margins in three cases. Read More

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http://dx.doi.org/10.1016/j.rmr.2019.01.001DOI Listing
January 2019
2 Reads

Trastuzumab-Based Combination Chemotherapy in Patients with Human Epidermal Growth Factor Receptor-2-Positive Metastatic Carcinoma ex Pleomorphic Adenoma.

Case Rep Oncol 2018 Sep-Dec;11(3):835-841. Epub 2018 Dec 11.

Department of Medical Oncology, Sapporo Medical University, Sapporo, Japan.

Background: Carcinoma ex pleomorphic adenoma (CXPA) is a rare histologic subtype of lacrimal gland and submandibular gland cancer. Currently, there is no standard treatment for metastatic CXPA, although some case reports have explored the role of targeted agents in chemotherapy. A few histopathologic analyses have shown that some of these tumors overexpress human epidermal growth factor receptor-2 (HER2), suggesting a potential role for HER2-based therapy. Read More

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http://dx.doi.org/10.1159/000495344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341428PMC
December 2018
10 Reads

An Unusual Variant of a Common Palatal Salivary Gland Tumor: Case Report of a Pleomorphic Adenoma with Significant Lipomatous Metaplasia.

Case Rep Dent 2018 25;2018:2052347. Epub 2018 Dec 25.

New York University College of Dentistry, 345 E 24th St, Room 837, NY, New York 10010, USA.

Introduction: Salivary gland tumors are relatively common in the junction of the hard and soft palate area of the oral cavity. Pleomorphic adenoma is considered the most common benign salivary gland tumor in this location. Some of the rarer subtypes of this tumor may have a misleading clinical presentation. Read More

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http://dx.doi.org/10.1155/2018/2052347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323424PMC
December 2018
4 Reads

[First bite syndrome after parapharyngeal space tumor surgery:two cases report].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Jan;33(1):81-84

Ten patients with parapharyngeal space tumor, all underwent surgery, which of two cases concurrent FBS,analyze its clinical characteristics and review the related literatures. Two cases complicated with FBS, both with primary healing of incision, the pathological diagnosis are pleomorphic adenoma and schwannoglioma respectively, both give non-steroidal anti-inflammatory drugs, paregoric and anticonvulsants, followed up for nine months and 16 months respectively, both two cases partial relief. FBS is one of surgical complications of parapharyngeal space,which should not be neglected by physicians. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2019.01.018DOI Listing
January 2019
2 Reads

Potential immmunohistochemical markers to characterize epithelial-mesenchymal transition in pleomorphic adenoma.

J Exp Ther Oncol 2019 Jan;13(1):1-7

Department of Oral Surgery, Pt. B. D Sharma University of Health Sciences, Post Graduate Institute of Dental Sciences, Rohtak, Haryana, India.

Backgound: The histogenesis process of pleomorphic adenoma (PA) of salivary gland continues to remain a controversial subject. In this neoplasm, transition occurs from an epithelial or myoepithelial cell to a stromal element and is called an epithelial-mesenchymal transition (EMT) resulting in heterogeneity. The present research was aimed to study the morphological characteristics of varied components and epithelial-mesenchymal transitions in PA using histopathological and immunohistochemical (IHC) analysis. Read More

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January 2019
4 Reads

[Clinical pathologic analysis on 3 724 cases of salivary gland tumors].

Zhonghua Kou Qiang Yi Xue Za Zhi 2019 Jan;54(1):10-16

Department of Pathology, Hospital of Stomatology, Jilin University, Changchun 130021, China.

To investigate the incidence and proportion of salivary gland tumors in order to provide new thinking for clinical diagnosis and treatment. Collected 3 724 cases salivary gland tumors diagnosed by Pathology Department of Hospital of Stomatology, Jilin University from January 1961 to December 2016. The pathological diagnosis referred to the fourth edition of head and neck-salivary gland tumor histopathological classification standard of WHO. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1002-0098.2019.01.003DOI Listing
January 2019
3 Reads

Lacrimal gland pleomorphic adenoma: a review of 52 cases, 15-year experience.

Acta Otolaryngol 2019 Jan 10;139(1):100-104. Epub 2019 Jan 10.

a Department of Otolaryngology - Orbital Surgery , Clinica Clarós , Barcelona , Spain.

Background: Lacrimal gland (LG) tumours are rare neoplasms. Pleomorphic adenoma (PA) is the most common histologic variant, representing ∼20% of all LG tumours. PA tends to recur leading to great morbidity. Read More

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http://dx.doi.org/10.1080/00016489.2018.1541362DOI Listing
January 2019
5 Reads

Classification of tumors by imaging diagnosis and preoperative fine-needle aspiration cytology in 120 patients with tumors in the parapharyngeal space.

Head Neck 2019 May 8;41(5):1277-1281. Epub 2019 Jan 8.

Otorhinolaryngology and Head and Neck Surgery, Kitasato University, Kanagawa, Japan.

Background: Tumors in the parapharyngeal space are rare, and preoperative diagnosis is difficult because of anatomical and histological complexity.

Methods: To evaluate the usefulness of preoperative diagnosis, we compared the classification of tumor localization in the prestyloid and retrostyloid compartments by imaging and preoperative cytological diagnosis by fine-needle aspiration cytology with the postoperative histopathological diagnosis in 120 patients with tumors in the parapharyngeal space.

Results: Tumors were located in the prestyloid and retrostyloid compartments in 68 and 52 patients, respectively. Read More

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http://doi.wiley.com/10.1002/hed.25552
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http://dx.doi.org/10.1002/hed.25552DOI Listing
May 2019
12 Reads

'Pleomorphic adenoma of the tongue: A common entity at the uncommon location'.

Ann Med Surg (Lond) 2019 Feb 23;38:34-36. Epub 2018 Dec 23.

Deptt. of Pathology, PGIMS Rohtak, Haryana, India.

The salivary gland tumors comprise of 3% of head and neck tumors. Pleomorphic adenoma, also known as mixed tumor, is the most common benign neoplasm of the major and minor salivary glands. The occurrence of pleomorphic adenoma of the tongue is very rare, and very few cases have been reported in the literature. Read More

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http://dx.doi.org/10.1016/j.amsu.2018.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312764PMC
February 2019
3 Reads

Comparative Role of Matrixins in Diagnostics of Parotid Gland Tumors.

Authors:
E V Kochurova

Bull Exp Biol Med 2019 Jan 8;166(3):383-385. Epub 2019 Jan 8.

I. M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the Russian Federation, Moscow, Russia.

The benign and malignant neoplasms in parotid gland have similar clinical presentations despite different tumor growth rates. The study compared the clinical and morphological data as well as the results of ELISA for MMP-2, MMP-8, MMP-9, TIMP-1, and TIMP-2 in salivary fluid yielded during primary examination of the patients with pleomorphic adenoma and adenocarcinoma of parotid gland. The examined biomarkers detected in salivary fluid in patients with various cancer types differed significantly (p≤0. Read More

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http://dx.doi.org/10.1007/s10517-019-04355-wDOI Listing
January 2019
2 Reads

Primary Pleomorphic Lipoma of the Parotid Gland with Prominent Myxoid Change: Report of a Rare Case Mimicking Carcinoma Ex Pleomorphic Adenoma on Fine Needle Aspiration Cytology.

Head Neck Pathol 2019 Jan 4. Epub 2019 Jan 4.

Department of Pathology, National University Hospital, Singapore, Singapore.

We present a case of a primary 2.5 cm pleomorphic lipoma of the right parotid gland with prominent myxoid change which on FNA displayed features that mimicked a carcinoma or sarcoma ex pleomorphic adenoma. The patient was a 79 year old man with no oncological history or tumor elsewhere. Read More

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http://link.springer.com/10.1007/s12105-018-00998-9
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http://dx.doi.org/10.1007/s12105-018-00998-9DOI Listing
January 2019
4 Reads

Salivary gland anlage tumor: molecular profiling sheds light on a morphologic question.

Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Dec 3. Epub 2018 Dec 3.

Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, USA.

Objective: Salivary gland anlage tumor (SGAT), previously described as a squamous proliferative lesion or "congenital pleomorphic adenoma," is a rare, benign entity that presents within the first months of life. It occurs almost exclusively in the nasopharynx or posterior nasal cavity and demonstrates a biphasic composition of epithelial and mesenchymal elements. Although the clinical and histologic features of SGAT are well described, its etiology remains poorly understood. Read More

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http://dx.doi.org/10.1016/j.oooo.2018.11.010DOI Listing
December 2018
2 Reads