2,370 results match your criteria Platelets[Journal]


Platelet-lymphocyte ratio (PLR) and all-cause mortality in general population: insights from national health and nutrition education survey.

Platelets 2019 Feb 13:1-6. Epub 2019 Feb 13.

a Division of Hospital Medicine , Virginia Commonwealth University , Richmond , VA , USA.

Platelet lymphocyte ratio (PLR) is a novel marker of inflammation that has gained popularity, especially in prognostication of cardiac diseases and malignant conditions. Several studies have examined the relationship between PLR and disease-specific mortality but none has examined this relationship with all-cause mortality in general population. Therefore, we examined the relationship between PLR and all-cause mortality using data from the National Health and Nutrition Examination Survey (NHANES) from the year 1999 to 2010. Read More

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http://dx.doi.org/10.1080/09537104.2019.1571188DOI Listing
February 2019

Plasma thrombopoietin levels as additional tool in clinical management of thrombocytopenic neonates.

Platelets 2019 Feb 13:1-6. Epub 2019 Feb 13.

a Department of Immunohematology Diagnostic Services Amsterdam , Sanquin Diagnostic Services , Amsterdam , The Netherlands.

Plasma thrombopoietin (Tpo) levels distinguish thrombocytopenia resulting from increased platelet destruction or decreased platelet production. We investigated whether measuring plasma Tpo levels in thrombocytopenic newborns is of diagnostic value to establish the underlying mechanism of thrombocytopenia. Tpo levels were measured with in-house developed ELISA in samples referred to our center because of thrombocytopenia noticed in the first 10 days of life. Read More

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http://dx.doi.org/10.1080/09537104.2019.1572877DOI Listing
February 2019

Platelet count correlates with stage and predicts survival in melanoma.

Platelets 2019 Feb 13:1-5. Epub 2019 Feb 13.

d Department of Microbiology and Immunology , Medical University of South Carolina , Charleston , SC , USA.

Cancer is a chronic inflammatory state which is often associated with increased platelet counts. Cancer cells induce thrombopoiesis and activate platelets, which in turn facilitate cancer invasion and metastasis. In this study, we investigate the correlation between platelet counts with each of stage and overall survival in melanoma. Read More

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http://dx.doi.org/10.1080/09537104.2019.1572879DOI Listing
February 2019
1 Read

Very-low-dose twice-daily aspirin maintains platelet inhibition and improves haemostasis during dual-antiplatelet therapy for acute coronary syndrome.

Platelets 2019 Feb 13:1-10. Epub 2019 Feb 13.

a Department of Infection, Immunity and Cardiovascular Disease , University of Sheffield , Sheffield , United Kingdom.

Higher aspirin doses may be inferior in ticagrelor-treated acute coronary syndrome (ACS) patients and reducing bleeding risk whilst maintaining antithrombotic benefits could improve outcomes. We characterized the pharmacodynamics of a novel dual-antiplatelet-therapy regimen consisting of very-low-dose twice-daily (BD) aspirin with standard-dose ticagrelor. A total of 20 ticagrelor-treated ACS patients entered a randomized crossover to take aspirin 20 mg BD (12-hourly) during one 14-day period and 75 mg once-daily (OD) in the other. Read More

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http://dx.doi.org/10.1080/09537104.2019.1572880DOI Listing
February 2019

De-escalation versus standard dual antiplatelet therapy in patients undergoing percutaneous coronary intervention: a systematic review and meta-analysis.

Platelets 2019 Feb 13:1-11. Epub 2019 Feb 13.

b Department of Cardiology , The First Hospital of Lanzhou University , Lanzhou , Gansu , China.

Switching from a potent P2Y blocker to clopidogrel is not uncommon for antiplatelet therapy in patients undergoing percutaneous coronary intervention. This meta-analysis aimed to investigate the efficacy and safety of this de-escalation strategy. Medical literature databases were searched for analysis comparing continued potent antiplatelet therapy and switching to clopidogrel with no language restrictions from inception to 07/May/2018. Read More

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http://dx.doi.org/10.1080/09537104.2019.1574969DOI Listing
February 2019

The effect of smoking on residual platelet reactivity to clopidogrel: a systematic review and meta-analysis.

Platelets 2019 Feb 11:1-12. Epub 2019 Feb 11.

a Department of Pharmacy , Peking University First Hospital , Beijing , China.

Cigarette smoking is an important cardiovascular risk factor, causing morbidity and mortality. There are many original studies on the impact of smoking, but its influence on platelet ADP-P2Y12 receptor inhibitors lack consistency. Thus, we conducted a systematic review and meta-analysis of already existing data/studies to further explore this issue. Read More

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http://dx.doi.org/10.1080/09537104.2019.1572878DOI Listing
February 2019
1 Read

First line treatment of adult patients with primary immune thrombocytopenia: a real-world study.

Platelets 2019 Feb 11:1-7. Epub 2019 Feb 11.

a Department of Hematology , Qilu Hospital, Shandong University , Jinan , China.

Immune thrombocytopenia (ITP) is an autoimmune disease with a mild to severe risk of bleeding complications. First line treatment includes corticosteroids, immunoglobulins, or other. In this large cohort study, first-line strategies for treatment-naive adult primary ITP was studied in a real-world setting. Read More

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http://dx.doi.org/10.1080/09537104.2019.1572875DOI Listing
February 2019
1 Read

Preoperative platelet counts and postoperative outcomes in cancer surgery: a multicenter, retrospective cohort study.

Platelets 2019 Feb 11:1-9. Epub 2019 Feb 11.

e Department of Radiation Oncology , Indiana University Health , Indianapolis , IN , USA.

Platelets play roles in malignancy, wound healing, and immunity. Nevertheless, their significance in postoperative outcomes is not established. This is a retrospective cohort study of 100,795 patients undergoing cancer surgery in 2010 and 2014 in >500 hospitals. Read More

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http://dx.doi.org/10.1080/09537104.2019.1573977DOI Listing
February 2019

The human platelet transcriptome and proteome is altered and pro-thrombotic functional responses are increased during prolonged hypoxia exposure at high altitude.

Platelets 2019 Feb 5:1-10. Epub 2019 Feb 5.

a Research Center for High Altitude Medicine , Qinghai University , Xining , Qinghai , China.

Exposure to hypoxia, through ascension to high altitudes (HAs), air travel, or human disease, is associated with an increased incidence of thrombosis in some settings. Mechanisms underpinning this increased thrombosis risk remain incompletely understood, and the effects of more sustained hypoxia on the human platelet molecular signature and associated functional responses have never been examined. We examined the effects of prolonged (≥2 months continuously) hypobaric hypoxia on platelets isolated from subjects residing at HA (3,700 meters) and, for comparison, matched subjects residing under normoxia conditions at sea level (50 meters). Read More

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https://www.tandfonline.com/doi/full/10.1080/09537104.2019.1
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http://dx.doi.org/10.1080/09537104.2019.1572876DOI Listing
February 2019
1 Read

A platelet viability assay (PVA) for the diagnosis of heparin-induced thrombocytopenia.

Platelets 2019 Jan 29:1-5. Epub 2019 Jan 29.

b Department of Medicine, Michael G. DeGroote School of Medicine , McMaster University , Hamilton , Ontario , Canada.

Diagnosing heparin-induced thrombocytopenia (HIT) requires functional assays measuring platelet activation as they are highly specific and sensitive. A useful functional test for diagnosing HIT is the serotonin release assay (SRA), but this assay is technically demanding and requires a radioactive marker. We describe an alternate functional HIT assay, the platelet viability assay (PVA), that overcomes the need for a radioactive marker by using a viability dye endpoint to measure platelet activation. Read More

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http://dx.doi.org/10.1080/09537104.2018.1562169DOI Listing
January 2019

Coexpression network analysis of platelet genes in sickle cell disease.

Platelets 2019 Jan 20:1-8. Epub 2019 Jan 20.

b Department of Blood Transfusion , Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , P. R. China.

Platelets play important roles in vascular health. Activation of platelet may contribute to coagulation and inflammation. Evidence suggests circulating platelets are chronically activated in sickle cell disease (SCD) patients with steady state and further activated in vaso-occlusive crisis. Read More

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http://dx.doi.org/10.1080/09537104.2018.1562170DOI Listing
January 2019
4 Reads

Small GTPases in megakaryocyte and platelet biology.

Platelets 2019 Jan 20:1-2. Epub 2019 Jan 20.

b Department of Biochemistry and Biophysics , University of North Carolina , Chapel Hill , NC , USA.

Review series that provides a state-of-the-art overview of the role of small GTPases in megakaryocyte and platelet biology. While the focus of the reviews is on recent advances in the area of basic science, the clinical relevance of alterations in small GTPase signaling for platelet count and function is also discussed. Read More

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http://dx.doi.org/10.1080/09537104.2018.1560938DOI Listing
January 2019
2 Reads

Favorable effect of glycoprotein IIbIIIa inhibitors among STEMI patients treated with primary PCI and incomplete ST resolution.

Platelets 2019 Jan 20:1-7. Epub 2019 Jan 20.

d Division of Cardiology , IRCCS Multimedica , Sesto San Giovanni (MI) , Italy.

Incomplete ST resolution after primary percutaneous coronary interventions (pPCI) in STEMI patients is a well known prognostic marker, associated with the occurrence of microvascular obstruction and increased mortality. The effects of the use of glycoprotein IIbIIIa inhibitors (GPIs) in this peculiar subset of high- risk patients is still unknown. The aim of the present study was to assess whether the GPIs administration would result in improved outcome in ST elevation myocardial infarction (STEMI) patients with incomplete ST resolution (ISTR). Read More

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http://dx.doi.org/10.1080/09537104.2018.1562171DOI Listing
January 2019
2 Reads

Circulating antiplatelet antibodies in pregnant women with immune thrombocytopenic purpura as predictors of thrombocytopenia in the newborns.

Platelets 2019 Jan 7:1-5. Epub 2019 Jan 7.

a National Medical Research Center for Cardiology , Ministry of Health , Moscow , Russian Federation.

Newborns from mothers with immune thrombocytopenic purpura (ITP) have a risk of thrombocytopenia due to passage of maternal antiplatelet antibodies into fetal/neonatal circulation. We looked for predictors of neonatal thrombocytopenia (nTP) in pregnant women with ITP. One hundred pregnant women with platelet count <100 × 10/l, no non-immune causes of thrombocytopenia and increased platelet associated IgG (PA-IgG) were included in the study. Read More

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https://www.tandfonline.com/doi/full/10.1080/09537104.2018.1
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http://dx.doi.org/10.1080/09537104.2018.1557615DOI Listing
January 2019
6 Reads

Impact of platelet reactivity on long-term prognosis in Korean patients receiving percutaneous coronary intervention.

Platelets 2019 Jan 2:1-6. Epub 2019 Jan 2.

a Department of Internal Medicine , St. Vincent's Hospital, The Catholic University of Korea , Suwon , South Korea.

Both high and low platelet responses to clopidogrel are highly associated with mortality. A therapeutic window for platelet reactivity was recently determined to be an important factor for improving clinical outcomes after percutaneous coronary intervention (PCI). We evaluated the impact of the antiplatelet activity of clopidogrel on long-term clinical outcomes in Korean patients receiving PCI. Read More

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http://dx.doi.org/10.1080/09537104.2018.1562172DOI Listing
January 2019
1 Read

Rapid testing of red blood cells, white blood cells and platelets in intensive care patients using the HemoScreen™ point-of-care analyzer.

Platelets 2018 Dec 28:1-4. Epub 2018 Dec 28.

c CIRRUS, Hedenstierna laboratory, Anaesthesiology and Intensive care, Department of Surgical Sciences, Anesthesiology , Uppsala University , Uppsala , Sweden.

Acute major bleeding is a condition that can be encountered in critically ill patients and may require rapid transfusions. To evaluate the need for packed red blood cells (RBCs) and platelets (PLTs), it is important to have rapid test results for RBC/hemoglobin and PLTs. Recently, PixCell Medical (Yokneam Ilit, Israel) introduced the HemoScreen™, an automated hematology analyzer. Read More

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https://www.tandfonline.com/doi/full/10.1080/09537104.2018.1
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http://dx.doi.org/10.1080/09537104.2018.1557619DOI Listing
December 2018
5 Reads

Randomized controlled trial protocol to investigate the antiplatelet therapy effect on extracellular vesicles (AFFECT EV) in acute myocardial infarction.

Platelets 2018 Dec 26:1-7. Epub 2018 Dec 26.

a 1st Chair and Department of Cardiology , Medical University of Warsaw , Warsaw , Poland.

Activated platelets contribute to thrombosis and inflammation by the release of extracellular vesicles (EVs) exposing P-selectin, phosphatidylserine (PS) and fibrinogen. P2Y12 receptor antagonists are routinely administered to inhibit platelet activation in patients after acute myocardial infarction (AMI), being a combined antithrombotic and anti-inflammatory therapy. The more potent P2Y12 antagonist ticagrelor improves cardiovascular outcome in patients after AMI compared to the less potent clopidogrel, suggesting that greater inhibition of platelet aggregation is associated with better prognosis. Read More

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http://dx.doi.org/10.1080/09537104.2018.1557616DOI Listing
December 2018
1 Read

The influence of hypoxia on platelet function and plasmatic coagulation during systemic inflammation in humans in vivo.

Platelets 2018 Dec 25:1-4. Epub 2018 Dec 25.

a Department of Intensive Care Medicine , Radboud University Medical Center , Nijmegen , The Netherlands.

Systemic inflammation and hypoxia frequently occur simultaneously in critically ill patients, and are both associated with platelet activation and coagulopathy. However, human in vivo data on the effects of hypoxia on platelet function and plasmatic coagulation under systemic inflammatory conditions are lacking. In the present study, 20 healthy male volunteers were randomized to either 3. Read More

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http://dx.doi.org/10.1080/09537104.2018.1557617DOI Listing
December 2018
3 Reads

Arachidonic acid causes lysis of blood cells and ADP-dependent platelet activation responses in platelet function tests.

Authors:
Sofia Ramström

Platelets 2018 Dec 24:1-7. Epub 2018 Dec 24.

a Department of Clinical Chemistry and Department of Clinical and Experimental Medicine , Linköping University , Linköping , Sweden.

The use of arachidonic acid (AA) to stimulate platelets is considered as a specific approach to study aspirin treatment efficacy. However, very high concentrations of AA are used, and it has been previously reported that AA can induce cell lysis in other settings. Several clinical studies have reported decreased responses to AA in whole blood tests in the presence of clopidogrel. Read More

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https://www.tandfonline.com/doi/full/10.1080/09537104.2018.1
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http://dx.doi.org/10.1080/09537104.2018.1557614DOI Listing
December 2018
7 Reads

A novel recombinant human thrombopoietin for treating prolonged isolated thrombocytopenia after allogeneic stem cell transplantation.

Platelets 2018 Dec 20:1-7. Epub 2018 Dec 20.

a Peking University People's Hospital, Peking University Institute of Haematology, Beijing Key Laboratory of Haematopoietic Stem Cell Transplantation for the Treatment of Haematological Diseases , Beijing , P.R. China.

Patients with prolonged isolated thrombocytopenia (PT) after allogeneic stem cell transplantation (allo-SCT) are known to have a poor prognosis. However, there is no standard treatment for PT. The present study aimed to investigate the potential effect of a novel recombinant human thrombopoietin (rhTPO) in a cohort of patients with PT following allo-SCT. Read More

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https://www.tandfonline.com/doi/full/10.1080/09537104.2018.1
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http://dx.doi.org/10.1080/09537104.2018.1557613DOI Listing
December 2018
5 Reads

The impact of rivaroxaban on primary hemostasis in patients with venous thrombosis.

Platelets 2018 Dec 20:1-5. Epub 2018 Dec 20.

b Department of Hematology , Oslo University Hospital , Oslo , Norway.

Factor Xa inhibitors are safe and effective alternatives to warfarin, but several studies indicate that rivaroxaban may cause a different risk profile for bleeding. For instance, while the risk of major bleeding in general may be lower with rivaroxaban than for warfarin, the risk of gastrointestinal bleeding or abnormal uterine bleeding may be higher. The underlying mechanisms for these differences are not known, and the effect of rivaroxaban on primary hemostasis is poorly understood. Read More

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http://dx.doi.org/10.1080/09537104.2018.1557618DOI Listing
December 2018
2 Reads

Protease-activated receptor 4 activity promotes platelet granule release and platelet-leukocyte interactions.

Platelets 2018 Dec 18:1-10. Epub 2018 Dec 18.

a Department of Biomedical Engineering , School of Medicine, Oregon Health & Science University , Portland , OR , USA.

Human platelets express two protease-activated receptors (PARs), PAR1 (F2R) and PAR4 (F2RL3), which are activated by a number of serine proteases that are generated during pathological events and cause platelet activation. Recent interest has focused on PAR4 as a therapeutic target, given PAR4 seems to promote experimental thrombosis and procoagulant microparticle formation, without a broadly apparent role in hemostasis. However, it is not yet known whether PAR4 activity plays a role in platelet-leukocyte interactions, which are thought to contribute to both thrombosis and acute or chronic thrombo-inflammatory processes. Read More

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https://www.tandfonline.com/doi/full/10.1080/09537104.2017.1
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http://dx.doi.org/10.1080/09537104.2017.1406076DOI Listing
December 2018
8 Reads

Investigation of the contribution of an underlying platelet defect in women with unexplained heavy menstrual bleeding.

Platelets 2018 Dec 6:1-9. Epub 2018 Dec 6.

b Institute of Cardiovascular Sciences, College of Medical and Dental Sciences , University of Birmingham , Birmingham , UK.

Heavy menstrual bleeding (HMB) is often undiagnosed in women and can cause discomfort and distress. A haemostatic cause for excessive bleeding is often not routinely investigated and can lead to hysterectomy at an early age. A prospective cohort study was carried out to determine whether certain patients with unexplained HMB have an underlying platelet function defect (PFD). Read More

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https://www.tandfonline.com/doi/full/10.1080/09537104.2018.1
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http://dx.doi.org/10.1080/09537104.2018.1543865DOI Listing
December 2018
12 Reads

Platelet reactivity in patients with chronic kidney disease undergoing percutaneous coronary intervention.

Platelets 2018 Dec 5:1-7. Epub 2018 Dec 5.

a Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases , The Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China.

This study aimed to evaluate the platelet reactivity in real-world patients with different chronic kidney disease (CKD) stages after percutaneous coronary intervention (PCI), and to examine whether high residual platelet reactivity (HRPR) is associated with higher incidence of adverse cardiovascular events in a 2-year follow up. A total of 10 724 consecutive patients receiving DAPT with aspirin and clopidogrel after PCI throughout 2013 were enrolled. We applied modified thromboelastography (mTEG) in 6745 patients. Read More

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http://dx.doi.org/10.1080/09537104.2018.1549319DOI Listing
December 2018
2 Reads

Comparison of treatments for persistent/chronic immune thrombocytopenia: a systematic review and network meta-analysis.

Platelets 2018 Dec 3:1-11. Epub 2018 Dec 3.

a Department of Hematology and Oncology , Graduate School of Medicine, Kyoto University , Kyoto , Japan.

Recent studies have indicated that medical options without splenectomy, such as rituximab (RTX) or thrombopoietin receptor agonists (TPO-RAs), can be effective to treat persistent or chronic primary immune thrombocytopenia (ITP). However, it remains to be determined which of these strategies should be the first choice after the first-line treatment for newly diagnosed ITP. We performed a systematic review and network meta-analysis to establish a clinically meaningful hierarchy of the efficacy and safety of medical treatments for persistent or chronic ITP in adults. Read More

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https://www.tandfonline.com/doi/full/10.1080/09537104.2018.1
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http://dx.doi.org/10.1080/09537104.2018.1543864DOI Listing
December 2018
9 Reads

Platelets - the second growth cycle.

Platelets 2018 Dec 4. Epub 2018 Dec 4.

c University of Birmingham , UK.

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http://dx.doi.org/10.1080/09537104.2019.1549810DOI Listing
December 2018
1 Read

Does plateletpheresis induce a hypercoagulable state? A global assessment of donor's hemostatic system by ROTEM.

Platelets 2018 Nov 29:1-5. Epub 2018 Nov 29.

c Department of Biostatistics , Eskişehir Osmangazi University Medical School , Eskisehir , Turkey.

Since there is still debate on the effects of plateletpheresis on coagulation system, we aimed to perform a global assessment of donor's hemostatic function undergoing plateletpheresis by rotation thromboelastometry (ROTEM) analysis and to clarify if plateletpheresis procedure induces a hypercoagulable state. Thirty male plateletpheresis donors were included in the study. Four blood samples were drawn at different time intervals: before the beginning of the apheresis procedure; immediately after the completion of the apheresis procedure; 24 h and 7 days after the apheresis procedure. Read More

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http://dx.doi.org/10.1080/09537104.2018.1542126DOI Listing
November 2018
3 Reads

Clinical value of the quantitation of average daily platelet increase during the recovery period in childhood acute lymphoblastic leukaemia.

Platelets 2018 Nov 29:1-4. Epub 2018 Nov 29.

b Pediatric department of Hematology, Key Laboratory of Birth Defects and Related Diseases of Women and Children , Sichuan University , Chengdu , Sichuan , P.R. China.

The time to platelet recovery (TPR) is becoming a predicting factor during the treatment of childhood acute leukaemia. However, the initial pre-treatment platelet count (PPC) could interfere with TPR. Here, we integrated both TPR and PPC as the average daily platelet amount increase (Ap) to predict the prognosis in childhood B-ALL during the recovery period. Read More

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http://dx.doi.org/10.1080/09537104.2018.1548011DOI Listing
November 2018
1 Read
2.627 Impact Factor

ABO antigen levels on platelets of normal and variant ABO blood group individuals.

Platelets 2018 Nov 26:1-7. Epub 2018 Nov 26.

a Blood Center of Zhejiang Province , Hangzhou , China.

Although differential expression of ABO antigens on platelets is related to recipients' platelet recovery and neonatal alloimmune thrombocytopenia in ABO-incompatible transfusion and pregnancy, the expression of ABO antigens on platelets in normal and variant ABO blood group individuals is rarely reported. Here, we analyzed the expression of ABO antigens on platelets in a cohort of 515 individuals with normal and variant ABO. The variants were also genotyped for ABO and/or FUT1 loci to distinguish inherited or acquired ABO variants. Read More

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http://dx.doi.org/10.1080/09537104.2018.1543863DOI Listing
November 2018
5 Reads

Of platelets and aggregometers: personal reminiscences of Gus Born (1921-2018).

Authors:
Rod J Flower

Platelets 2018 Dec 26;29(8):749-755. Epub 2018 Nov 26.

a The William Harvey Research Institute , Queen Mary University of London , London , UK.

This paper recounts the author's personal reminiscences of the late Gustav Born and details some of his major influences on the field of platelet biology and mechanisms of hemostasis. In particular, it focuses on his development of the 'Born aggregometer' and the differences that are seen in the aggregation response to certain stimuli when aggregation is recorded using other techniques such as the impedance method. Read More

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http://dx.doi.org/10.1080/09537104.2018.1533740DOI Listing
December 2018
1 Read

CYCS gene variants associated with thrombocytopenia.

Platelets 2018 Nov 19:1-3. Epub 2018 Nov 19.

b Department of Pathology, Dunedin School of Medicine , University of Otago , Dunedin , New Zealand.

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http://dx.doi.org/10.1080/09537104.2018.1543866DOI Listing
November 2018
1 Read

Impact of immature platelet fraction on platelet reactivity during prasugrel maintenance treatment.

Platelets 2018 Nov 13:1-8. Epub 2018 Nov 13.

a Division of Cardiology , Azienda Ospedaliera-Universitaria "Maggiore della Carità", Eastern Piedmont University, Novara, Italy.

Residual high on-treatment platelet reactivity (HTPR) despite dual antiplatelet therapy (DAPT) has emerged as a predictor of major ischemic events in patients undergoing percutaneous coronary interventions (PCIs), especially after an acute cardiovascular event. However, its determinants are still poorly defined. Therefore, the aim of the present study was to evaluate the role of the percentage of reticulated platelets on HTPR in patients on DAPT with ASA (100-160 mg) and prasugrel (10 mg). Read More

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https://www.tandfonline.com/doi/full/10.1080/09537104.2018.1
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http://dx.doi.org/10.1080/09537104.2018.1535707DOI Listing
November 2018
9 Reads

Chronic liver disease, thrombocytopenia and procedural bleeding risk; are novel thrombopoietin mimetics the solution?

Platelets 2018 Nov 13:1-3. Epub 2018 Nov 13.

a Division of Hematology and Medical Oncology , Oregon Health and Science University, Knight Cancer Institute , Portland , OR , USA.

Chronic liver disease (CLD) alters normal hemostatic and thrombotic systems via multiple mechanisms including reduced platelet function and number, leading to challenging peri-operative planning. Hepatic thrombopoietin (TPO) synthesis is reduced in CLD, leading to several recent randomized, placebo-controlled trials examining the utility of TPO-mimetics to increase platelet counts prior to surgery. While these trials do suggest that TPO-mimetics are efficacious at increasing platelet counts in patients with CLD and have led to several recent drug approvals in this space by the U. Read More

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https://www.tandfonline.com/doi/full/10.1080/09537104.2018.1
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http://dx.doi.org/10.1080/09537104.2018.1542125DOI Listing
November 2018
31 Reads

Increased platelet reactivity and platelet-leukocyte aggregation after elective coronary bypass surgery.

Platelets 2018 Nov 13:1-7. Epub 2018 Nov 13.

b Department of Clinical Pharmacology, Karolinska University Hospital and Department of Medicine Solna , Karolinska Institutet , Stockholm , Sweden.

Inflammatory mechanisms are activated, and thrombotic complications occur during the initial months after coronary artery bypass grafting (CABG). Therefore, changes over time of platelet activation and platelet-leukocyte interactions after CABG are of interest. Whole-blood flow cytometry was performed before, and 4-6 days, one month, and three months after elective CABG in 54 men with stable coronary artery disease treated with acetylsalicylic acid (ASA). Read More

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https://www.tandfonline.com/doi/full/10.1080/09537104.2018.1
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http://dx.doi.org/10.1080/09537104.2018.1542122DOI Listing
November 2018
8 Reads

Perioperative point of care platelet function testing and postoperative blood loss in high-risk cardiac surgery patients.

Platelets 2018 Nov 9:1-7. Epub 2018 Nov 9.

a Department of Anaesthesia, Intensive Care and Pain Medicine , St Antonius Hospital , Nieuwegein , The Netherlands.

Postoperative coagulopathic bleeding is common in cardiac surgery and associated with increased morbidity and mortality. Platelet function is affected by multiple factors, including patient and procedural characteristics. Point-of-care (POC) multiple electrode aggregometry (MEA) can rapidly detect and quantify platelet dysfunction and could contribute to optimal patient blood management. Read More

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https://www.tandfonline.com/doi/full/10.1080/09537104.2018.1
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http://dx.doi.org/10.1080/09537104.2018.1542123DOI Listing
November 2018
15 Reads

Gustav Born: pioneer in imaging platelet and leukocyte biology.

Platelets 2018 Dec 9;29(8):766-770. Epub 2018 Nov 9.

a Sackler Institute of Pulmonary Pharmacology, Institute of Pharmaceutical Science , King's College London , London , UK.

Gustav Born achieved scientific fame for his application of light transmission aggregometry to the study of platelet function, but also led interdisciplinary research teams in pioneering quantitative in vivo imaging studies of platelet aggregation and leukocyte adhesion, and in conducting the first research into the biomechanical factors underlying atherosclerotic plaque rupture. Gus Born also communicated both current research findings and an integrated understanding of cardiovascular biology to a wide audience through acting as scientific advisor on several television productions. Using footage from two of these films, we discuss Gustav Born's scientific achievements and legacy. Read More

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https://www.tandfonline.com/doi/full/10.1080/09537104.2018.1
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http://dx.doi.org/10.1080/09537104.2018.1535001DOI Listing
December 2018
10 Reads

Anagrelide is an anti-megakaryocytic and not an anti-platelet agent.

Platelets 2018 Nov 7:1-2. Epub 2018 Nov 7.

a IBR: Level 1, Institute of Cardiovascular Sciences, College of Medical and Dental Sciences , University of Birmingham , Birmingham , United Kingdom.

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http://dx.doi.org/10.1080/09537104.2018.1542124DOI Listing
November 2018
1 Read

SerpinB2 deficiency in mice reduces bleeding times via dysregulated platelet activation.

Platelets 2018 Nov 2:1-6. Epub 2018 Nov 2.

a QIMR Berghofer Medical Research Institute , Brisbane , Australia.

SerpinB2, also known as plasminogen activation inhibitor type 2 (PAI-2), is classically viewed as an inhibitor of fibrinolysis. However, we show herein a distinct, hitherto unrecognized role for SerpinB2 in hemostasis. Mice deficient in SerpinB2 expression and mice with an active site mutation in SerpinB2, both showed significant reductions in tail bleeding times. Read More

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http://dx.doi.org/10.1080/09537104.2018.1535702DOI Listing
November 2018
3 Reads

Severe obesity and bariatric surgery alter the platelet mRNA profile.

Platelets 2018 Nov 2:1-8. Epub 2018 Nov 2.

a Department of Medicine, Leon H. Charney Division of Cardiology and the Center for the Prevention of Cardiovascular Disease , New York University School of Medicine , New York , NY , USA.

Mechanisms explaining the relationship between obesity and cardiovascular disease (CVD) are needed. Despite growing recognition of the importance of the anucleate platelet transcriptome, low levels of RNA in platelets make assessment difficult. We sought to perform unbiased platelet RNA profiling in obesity by performing a prospective study of severe obesity and weight loss via bariatric surgery on platelet characteristics and mRNA profile in 26 pre-menopausal, non-diabetic women (31. Read More

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https://www.tandfonline.com/doi/full/10.1080/09537104.2018.1
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http://dx.doi.org/10.1080/09537104.2018.1536261DOI Listing
November 2018
9 Reads

Gus Born: Scientific Reflections of Later Years, Inspiring the Next Generation of Blood Researchers.

Platelets 2018 Dec 30;29(8):763-765. Epub 2018 Oct 30.

a Systems Immunity Research Institute, School of Medicine, Cardiff University , Cardiff , Wales , UK.

I am delighted to have been be asked by Steve Watson to write a short piece for this series in Platelets, on my friendship with Prof Gus Born which began in 2011, when he came to Cardiff to present at our UK Platelets meeting. Gus was an insipiration, his story resonates today and it is an honour to have the opportunity to record a summary of our meetings here. Read More

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December 2018
2 Reads

Gustav Born and life as "a series of ripples widening out from an original centre".

Authors:
Carlo Patrono

Platelets 2018 12 30;29(8):761-762. Epub 2018 Oct 30.

a Department of Pharmacology , Catholic University School of Medicine , Rome , Italy.

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http://dx.doi.org/10.1080/09537104.2018.1535289DOI Listing
December 2018
8 Reads

Multifocal avascular necrosis in a patient with refractory immune thrombocytopenia and antiphospholipid antibodies; case report and review of literature.

Platelets 2018 Oct 29:1-8. Epub 2018 Oct 29.

a Rheumatology & Clinical Immunology Unit, Internal Medicine Department, Faculty of Medicine , Cairo University , Cairo , Egypt.

Avascular necrosis (AVN) is a devastating condition that is rarely reported in patients with immune thrombocytopenia (ITP). Treatment with steroids remains a major risk factor for developing AVN. However, the incidence of AVN in patients with ITP requiring corticosteroid therapy is much less than that observed with other clinical conditions requiring corticosteroids. Read More

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October 2018
4 Reads
2.627 Impact Factor

Small GTPases in platelet membrane trafficking.

Platelets 2018 Oct 26:1-10. Epub 2018 Oct 26.

a From the School of Physiology, Pharmacology and Neuroscience, Biomedical Sciences Building , University of Bristol , Bristol , UK.

Our understanding of fundamental biological processes within platelets is continually evolving. A critical feature of platelet biology relates to the intricate uptake, packaging and release of bioactive cargo from storage vesicles, essential in mediating a range of classical (haemostasis/thrombosis) and non-classical (regeneration/inflammation/metastasis) roles platelets assume. Pivotal to the molecular control of these vesicle trafficking events are the small GTPases of the Ras superfamily, which function as spatially distinct, molecular switches controlling essential cellular processes. Read More

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http://dx.doi.org/10.1080/09537104.2018.1535703DOI Listing
October 2018
11 Reads

Evaluation of the Total Thrombus-Formation System (T-TAS): application to human and mouse blood analysis.

Platelets 2018 Oct 26:1-8. Epub 2018 Oct 26.

a Institute of Inflammation and Ageing , University of Birmingham , Birmingham , UK.

The Total Thrombus-formation Analyser System (T-TAS) is a whole blood flow chamber system for the measurement of in vitro thrombus formation under variable shear stress conditions. Our current study sought to evaluate the potential utility of the T-TAS for the measurement of thrombus formation within human and mouse whole blood. T-TAS microchips (collagen, PL chip; collagen/tissue thromboplastin, AR chip) were used to analyze platelet (PL) or fibrin-rich thrombus formation, respectively. Read More

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http://dx.doi.org/10.1080/09537104.2018.1535704DOI Listing
October 2018
7 Reads

An interview with Professor Gus Born.

Platelets 2018 Dec 26;29(8):744-748. Epub 2018 Oct 26.

b Faculté de pharmacie , Université de Montréal , Montréal , Québec , Canada.

This article is taken from an interview with Professor Gustav Victor Rudolf Born (known as Gus), and focuses on his personal reflections and his distinguished career. Professor Born's innovative research led to the development of a pioneering device, the aggregometer, which opened up the field of platelet research. In this article, Professor Born gives his modest insight into the early stages of his career and the impact Hiroshima had on his decision to work on thrombosis and hemostasis. Read More

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December 2018
1 Read

Platelet function after cardiac surgery and its association with severe postoperative bleeding: the PLATFORM study.

Platelets 2018 Oct 26:1-7. Epub 2018 Oct 26.

a Department of Cardiothoracic, Vascular Anaesthesia and Intensive Care , IRCCS Policlinico San Donato , Milan , Italy.

Platelet dysfunction after cardiac surgery is a determinant of postoperative bleeding. The existing guidelines suggest the use of desmopressin and/or platelet concentrate transfusions in case of platelet dysfunction in bleeding patients, but no cut-off values for platelet activity exist in the literature. The Platelet Function in the Operating Room (PLATFORM) study aims to identify the relationship between platelet function after cardiopulmonary bypass and severe bleeding, finding adequate predictive values of platelet function for severe bleeding. Read More

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http://dx.doi.org/10.1080/09537104.2018.1535706DOI Listing
October 2018
5 Reads

Agreement between blood draw techniques for assessing platelet activation by flow cytometry.

Platelets 2018 Oct 26:1-5. Epub 2018 Oct 26.

a Respiratory Research Group, Hull York Medical School, Castle Hill Hospital , Cottingham , UK.

It is widely believed that assays of platelet activation are susceptible to preanalytical variables related to blood draw technique. We assessed platelet activation by whole blood flow cytometry and investigated the effects of: (1) drawing blood into vacuum tubes or manually aspirated syringes, and (2) discarding the first drawn blood sample (discard tube). Platelet P-selectin expression and platelet-monocyte complexes were measured by flow cytometry under both basal conditions and following stimulation with 0. Read More

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http://dx.doi.org/10.1080/09537104.2018.1535705DOI Listing
October 2018
10 Reads

Influence of concentration and preparation of platelet rich fibrin on human bone marrow mononuclear cells (in vitro).

Platelets 2018 Oct 25:1-10. Epub 2018 Oct 25.

b Clinic for Maxillofacial and Plastic Surgery , FORM, Frankfurt Oral Regenerative Medicine, Johann Wolfgang Goethe University , Frankfurt Am Main , Germany.

Large bone defects have always been a big challenge. The use of bone marrow mononuclear cells (BMCs) combined with an osteoconductive scaffold has been proved a good alternative for the treatment of large bone defects. Another autologous source for tissue engineering is platelet rich fibrin (PRF). Read More

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http://dx.doi.org/10.1080/09537104.2018.1530346DOI Listing
October 2018
2 Reads

MicroRNA function in megakaryocytes.

Platelets 2018 Oct 25:1-8. Epub 2018 Oct 25.

a Stem Cells and Haematological Disorders Laboratory, Department of Biochemistry , School of Life Sciences, University of Hyderabad , Hyderabad , TS , India.

Megakaryocytes (MKs), the largest cells in the bone marrow, are generated from hematopoietic stem cells (HSCs) in a sequential process called megakaryocytopoiesis in which HSCs undergo MK-progenitor (MP) commitment and maturation to terminally differentiated MK. Megakaryocytopoiesis is controlled by a complex network of bone marrow niche factors. Traditionally, the studies on megakaryocytopoiesis were focused on different cytokines, growth factors and transcription factors as the regulators of megakaryocytopoiesis. Read More

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http://dx.doi.org/10.1080/09537104.2018.1528343DOI Listing
October 2018
9 Reads
2.630 Impact Factor

High-intensity intermittent exercise increases adenosine hydrolysis in platelets and lymphocytes and promotes platelet aggregation in futsal athletes.

Platelets 2018 Oct 22:1-8. Epub 2018 Oct 22.

d Academic Coordination, Medicine, Campus Chapecó , Federal University of Fronteira Sul , Chapecó , SC , Brazil.

Acute bouts of high-intensity intermittent exercise (HIIE) or sports are associated with changes in lymphocytes and platelet functions and we hypothesized that the purinergic system is involved with these alterations. We investigated the activity of ectonucleotidases in platelets and lymphocytes as well as the platelet aggregation of futsal players in response to an acute protocol of HIIE. Thus, 19 male semi-professional futsal players were submitted to 40 min of HIIE on a treadmill. Read More

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https://www.tandfonline.com/doi/full/10.1080/09537104.2018.1
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http://dx.doi.org/10.1080/09537104.2018.1529299DOI Listing
October 2018
4 Reads