2,388 results match your criteria Platelets[Journal]


A major interspecies difference in the ionic selectivity of megakaryocyte Ca-activated channels sensitive to the TMEM16F inhibitor CaCCinh-A01.

Platelets 2019 Apr 22:1-5. Epub 2019 Apr 22.

a Department of Molecular and Cell Biology , University of Leicester , Leicester , UK.

TMEM16F is a surface membrane protein critical for platelet procoagulant activity, which exhibits both phospholipid scramblase and ion channel activities following sustained elevation of cytosolic Ca. The extent to which the ionic permeability of TMEM16F is important for platelet scramblase responses remains controversial. To date, only one study has reported the electrophysiological properties of TMEM16F in cells of platelet/megakaryocyte lineage, which observed cation-selectivity within excised patch recordings from murine marrow-derived megakaryocytes. Read More

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https://www.tandfonline.com/doi/full/10.1080/09537104.2019.1
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http://dx.doi.org/10.1080/09537104.2019.1595560DOI Listing
April 2019
1 Read

Platelet function in preeclampsia - a systematic review and meta-analysis.

Platelets 2019 Apr 14:1-14. Epub 2019 Apr 14.

a Centre for Haemophilia and Thrombosis, Department of Clinical Biochemistry , Aarhus University Hospital , Aarhus , Denmark.

Preeclampsia is a serious pregnancy-related complication. Platelets are potentially important in the pathogenesis of preeclampsia, and platelet function analyses may prove as sensitive preeclampsia biomarkers. This study aimed to systematically review and summarise the literature on platelet function markers in preeclampsia. Read More

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http://dx.doi.org/10.1080/09537104.2019.1595561DOI Listing
April 2019
1 Read

Application of high-sensitivity flow cytometry in combination with low-voltage scanning electron microscopy for characterization of nanosized objects during platelet concentrate storage.

Platelets 2019 Apr 12:1-10. Epub 2019 Apr 12.

a Institute of molecular biology and genetics , Almazov National Medical Research Centre , St. Petersburg , Russia.

Platelet concentrates are used in clinic for therapy and prophylaxis of conditions associated with platelet deficiency or malfunction. The characteristics of platelet concentrates gradually change during pretransfusion storage, affecting their clinical effectiveness and the risk of adverse transfusion reactions. The presence of platelet-derived membrane vesicles is an important characteristic of platelet concentrates. Read More

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http://dx.doi.org/10.1080/09537104.2019.1599337DOI Listing
April 2019
1 Read

Evaluation of an in vitro coronary stent thrombosis model for preclinical assessment.

Platelets 2019 Apr 11:1-7. Epub 2019 Apr 11.

a CAPITAL Research Group , University of Ottawa Heart Institute , Ottawa , Ontario , Canada.

Stent thrombosis remains an infrequent but significant complication following percutaneous coronary intervention. Preclinical models to rapidly screen and validate therapeutic compounds for efficacy are lacking. Herein, we describe a reproducible, high throughput and cost-effective method to evaluate candidate therapeutics and devices for either treatment or propensity to develop stent thrombosis in an in vitro bench-top model. Read More

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http://dx.doi.org/10.1080/09537104.2019.1595564DOI Listing

Whole blood platelet aggregation determined by the ROTEM platelet equipment; reference intervals and stability.

Platelets 2019 Apr 1:1-6. Epub 2019 Apr 1.

a Department of Clinical Biochemistry , Aarhus University Hospital , Aarhus , Denmark.

Point of care testing of residual effect of antiplatelet therapy in trauma patients or during major surgery may result in improved clinical management of significant bleeding. We included 121 healthy individuals (57 females and 64 males, aged 22-65 years) in order to establish reference intervals for platelet aggregation induced by adenosine diphosphate (ADPTEM, 10 µM), arachidonic acid (ARATEM, 0.42 mM) and thrombin activating peptide (TRAPTEM, 36 µM) employing the ROTEM platelet module. Read More

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http://dx.doi.org/10.1080/09537104.2019.1595562DOI Listing
April 2019
1 Read

Platelet-rich plasma (PRP) and tendon healing: comparison between fresh and frozen-thawed PRP.

Platelets 2019 Mar 27:1-5. Epub 2019 Mar 27.

h Experimental Surgery, GIGA-R & Credec , University of Liège , Liège , Belgium.

Platelet-rich plasma (PRP) is increasingly used in the treatment of musculoskeletal diseases. Its preservation by freezing it for the realization of multiple injections in clinical use has never been discussed. Calcaneal tendons of rats were surgically sectioned. Read More

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http://dx.doi.org/10.1080/09537104.2019.1595563DOI Listing

Effect of acetylsalicylic acid intake on platelet derived microvesicles in healthy subjects.

Platelets 2019 Mar 21:1-9. Epub 2019 Mar 21.

b Laboratory of Flow Cytometry and Vascular Biology, Department of Neurology , Poznan University of Medical Sciences , Poznan , Poland.

Platelet-derived microvesicles (pMVs) are released from platelets in physiological and pathological conditions and exhibit a wide range of prothrombotic, antithrombotic, proatherogenic, and pro-inflammatory properties. Antiplatelet agents, such as acetylsalicylic acid (ASA), are widely used for the prevention and treatment of vascular diseases, but their impact on pMV release remains poorly understood and contradictory mainly because of discrepancies in the methodology and lack of well-standardized MV assessment protocols. The present study investigated the effects of ASA not only on total pMV release but also on their phenotypes defined using the surface expression of pro-inflammatory (CD40L, CD62P, CD31) and procoagulant (PS, PAC-1) markers in healthy subjects. Read More

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http://dx.doi.org/10.1080/09537104.2019.1588242DOI Listing
March 2019
6 Reads

Evaluation of platelet function in essential thrombocythemia under different analytical conditions.

Platelets 2019 Mar 20:1-8. Epub 2019 Mar 20.

a Medicina II, ASST Santi Paolo e Carlo - Dipartimento di Scienze della Salute , Università degli Studi di Milano , Milano Italy.

Background: Studies of platelet aggregation (PA) in essential thrombocythemia (ET) reported contrasting results, likely due to differences in analytical conditions.

Objective: We investigated platelet aggregation using different techniques and analytical conditions.

Patients And Methods: PA was studied by light-transmission aggregometry (LTA) in platelet-rich plasma (PRP) and impedance aggregometry in PRP and whole blood (WB). Read More

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http://dx.doi.org/10.1080/09537104.2019.1584668DOI Listing
March 2019
1 Read

Circulating microRNAs in patients with immune thrombocytopenia before and after treatment with thrombopoietin-receptor agonists.

Platelets 2019 Mar 18:1-8. Epub 2019 Mar 18.

b Center for Laboratory Medicine , Østfold Hospital Trust , Grålum , Norway.

MicroRNAs (miRNAs) are small non-coding RNAs involved in the regulation of gene expression. Dysregulated expression of several miRNAs has been found in primary immune thrombocytopenia (ITP) suggesting that miRNAs are likely involved in the pathogenesis of ITP. We aimed to explore the differential expression of miRNAs in patients with ITP before and after starting treatment with thrombopoietin-receptor agonists (TPO-RAs) to clarify their roles in the pathophysiology of ITP, and as potential diagnostic and prognostic markers of this disorder. Read More

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http://dx.doi.org/10.1080/09537104.2019.1585527DOI Listing

Acknowledgements: the Levin/Kile rule.

Platelets 2019 ;30(2):280

b Developmental Biology, Monash Biomedicine Discovery Institute , Monash University , VIC , Australia.

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http://dx.doi.org/10.1080/09537104.2019.1565938DOI Listing

Rac1 regulates platelet microparticles formation and rheumatoid arthritis deterioration.

Authors:
Xue Chen

Platelets 2019 Mar 17:1-8. Epub 2019 Mar 17.

a Department of Biochemistry and Molecular Cell Biology , Shanghai Key Laboratory of Tumor Microenvironment and Inflammation , Shanghai , China.

Platelets play important roles in blood clotting, hemostasis and wound repair, while more and more research show that platelets also have significant contributions in the process of inflammation. Rheumatoid arthritis is a chronic systemic inflammatory autoimmune disease. Platelet microparticles, which are membrane vesicles shed by activated platelets, are reported to amplify inflammation in Rheumatoid arthritis. Read More

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http://dx.doi.org/10.1080/09537104.2019.1584669DOI Listing
March 2019
1 Read

RASGRP2 gene variations associated with platelet dysfunction and bleeding.

Platelets 2019 8;30(4):535-539. Epub 2019 Mar 8.

a Servicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonación , Universidad de Murcia , Murcia , Spain.

This manuscript reviews pathogenic variants in RASGRP2, which are the cause of a relatively new autosomal recessive and nonsyndromic inherited platelet function disorder, referred to as platelet-type bleeding disorder-18 (BDPLT18)(OMIM:615888). To date, 18 unrelated BDPLT18 pedigrees have been reported, harboring 19 different homozygous or compound heterozygous RASGRP2 variants. Patients with this disease present with lifelong moderate to severe bleeding, with epistaxis as the most common and relevant bleeding symptom. Read More

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http://dx.doi.org/10.1080/09537104.2019.1585528DOI Listing
March 2019
2 Reads

Comparison of the GPVI inhibitors losartan and honokiol.

Platelets 2019 Mar 8:1-11. Epub 2019 Mar 8.

a Institute of Cardiovascular Sciences, IBR Building , College of Medical and Dental Sciences, University of Birmingham , Birmingham , UK.

Losartan and honokiol are small molecules which have been described to inhibit aggregation of platelets by collagen. Losartan has been proposed to block clustering of GPVI but not to affect binding of collagen. Honokiol has been reported to bind directly to GPVI but only at a concentration that is three orders of magnitude higher than that needed for inhibition of aggregation. Read More

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http://dx.doi.org/10.1080/09537104.2019.1585526DOI Listing
March 2019
1 Read

Platelets compensate for poor thrombin generation in type 3 von Willebrand disease.

Platelets 2019 Mar 5:1-9. Epub 2019 Mar 5.

b Faculty of Medicine , University of Helsinki , Helsinki , Finland.

In type 3 von Willebrand disease (VWD3), the most severe form with absent von Willebrand factor (VWF), the bleeding phenotype is variable. Platelet contribution to the hemostatic defect in VWD3 calls upon further studies. We investigated the contribution of platelets to in vitro thrombin generation (TG) and platelet procoagulant activity in VWD3. Read More

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http://dx.doi.org/10.1080/09537104.2019.1581922DOI Listing
March 2019
2 Reads

Platelet Contribution to Clot Strength in Thromboelastometry: Count, Function, or Both?

Platelets 2019 Mar 4:1-6. Epub 2019 Mar 4.

a Department Of Cardiovascular Anaesthesia and Intensive Care Unit , IRCCS Policlinico San Donato , San Donato Milanese , Milan , Italy.

In thromboelastometry (ROTEM) the difference in amplitude between the EXTEM and the FIBTEM is considered an index of platelet contribution to clot strength (PCS). The difference in elasticity (PCS) is rarely used. We investigated the ability of PCS and PCS in reflecting platelet count and function in 103 patients undergoing cardiac surgery, simultaneously measuring ROTEM and platelet function tests (multiple electrode aggregometry ADPtest and TRAPtest, Multiplate). Read More

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http://dx.doi.org/10.1080/09537104.2019.1581920DOI Listing
March 2019
2 Reads

Efficacy and safety of thrombopoietin receptor agonists in children with chronic immune thrombocytopenic purpura: meta-analysis.

Platelets 2019 Feb 27:1-8. Epub 2019 Feb 27.

a Department of Pediatrics , Fujian Medical University Union Hospital , Fuzhou , Fujian Province , China.

Immune thrombocytopenic purpura (ITP) is an autoimmune disorder presenting with low platelet count <100 × 10/L. The condition affects both adults and children. Thrombopoietin receptor agonists (TPO-RAs) are second-line of therapy that includes Romiplostim and Eltrombopag, which stimulate the production of normally functioning platelets. Read More

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http://dx.doi.org/10.1080/09537104.2019.1572873DOI Listing
February 2019
1 Read

Platelet count as a new biomarker for acute kidney injury induced by hemorrhagic shock.

Platelets 2019 Feb 27:1-9. Epub 2019 Feb 27.

a Department of Critical Care Medicine , The Second People's Hospital of Shenzhen & First Affiliated Hospital of Shenzhen University, Health Science Center , Shenzhen , China.

The aim of this study was to investigate the association between nadir platelet count and acute kidney injury (AKI) or 28-day all-cause mortality induced by hemorrhagic shock (HS), and to determine the cutoff value of nadir platelet count in HS clinical practice. This retrospective study included hospitalized patients enrolled in a tertiary-care teaching hospital from January 1, 2010 to December 31, 2015. Clinical data from HS admitted to the intensive care unit (ICU) were evaluated. Read More

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http://dx.doi.org/10.1080/09537104.2019.1581921DOI Listing
February 2019
1 Read

Assessment of neonatal, cord, and adult platelet granule trafficking and secretion.

Platelets 2019 Feb 27:1-11. Epub 2019 Feb 27.

e The Hemophilia Center , Oregon Health & Science University , Portland , OR , USA.

Despite the transient hyporeactivity of neonatal platelets, full-term neonates do not display a bleeding tendency, suggesting potential compensatory mechanisms which allow for balanced and efficient neonatal hemostasis. This study aimed to utilize small-volume, whole blood platelet functional assays to assess the neonatal platelet response downstream of the hemostatic platelet agonists thrombin and adenosine diphosphate (ADP). Thrombin activates platelets via the protease-activated receptors (PARs) 1 and 4, whereas ADP signals via the receptors P2Y and P2Y as a positive feedback mediator of platelet activation. Read More

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https://www.tandfonline.com/doi/full/10.1080/09537104.2019.1
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http://dx.doi.org/10.1080/09537104.2019.1573314DOI Listing
February 2019
11 Reads

Platelet-lymphocyte ratio (PLR) and all-cause mortality in general population: insights from national health and nutrition education survey.

Platelets 2019 Feb 13:1-6. Epub 2019 Feb 13.

a Division of Hospital Medicine , Virginia Commonwealth University , Richmond , VA , USA.

Platelet lymphocyte ratio (PLR) is a novel marker of inflammation that has gained popularity, especially in prognostication of cardiac diseases and malignant conditions. Several studies have examined the relationship between PLR and disease-specific mortality but none has examined this relationship with all-cause mortality in general population. Therefore, we examined the relationship between PLR and all-cause mortality using data from the National Health and Nutrition Examination Survey (NHANES) from the year 1999 to 2010. Read More

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http://dx.doi.org/10.1080/09537104.2019.1571188DOI Listing
February 2019
5 Reads

Plasma thrombopoietin levels as additional tool in clinical management of thrombocytopenic neonates.

Platelets 2019 Feb 13:1-6. Epub 2019 Feb 13.

a Department of Immunohematology Diagnostic Services Amsterdam , Sanquin Diagnostic Services , Amsterdam , The Netherlands.

Plasma thrombopoietin (Tpo) levels distinguish thrombocytopenia resulting from increased platelet destruction or decreased platelet production. We investigated whether measuring plasma Tpo levels in thrombocytopenic newborns is of diagnostic value to establish the underlying mechanism of thrombocytopenia. Tpo levels were measured with in-house developed ELISA in samples referred to our center because of thrombocytopenia noticed in the first 10 days of life. Read More

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https://www.tandfonline.com/doi/full/10.1080/09537104.2019.1
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http://dx.doi.org/10.1080/09537104.2019.1572877DOI Listing
February 2019
3 Reads

Platelet count correlates with stage and predicts survival in melanoma.

Platelets 2019 02 13:1-5. Epub 2019 Feb 13.

d Department of Microbiology and Immunology , Medical University of South Carolina , Charleston , SC , USA.

Cancer is a chronic inflammatory state which is often associated with increased platelet counts. Cancer cells induce thrombopoiesis and activate platelets, which in turn facilitate cancer invasion and metastasis. In this study, we investigate the correlation between platelet counts with each of stage and overall survival in melanoma. Read More

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http://dx.doi.org/10.1080/09537104.2019.1572879DOI Listing
February 2019
10 Reads

Very-low-dose twice-daily aspirin maintains platelet inhibition and improves haemostasis during dual-antiplatelet therapy for acute coronary syndrome.

Platelets 2019 13;30(2):148-157. Epub 2019 Feb 13.

a Department of Infection, Immunity and Cardiovascular Disease , University of Sheffield , Sheffield , United Kingdom.

Higher aspirin doses may be inferior in ticagrelor-treated acute coronary syndrome (ACS) patients and reducing bleeding risk whilst maintaining antithrombotic benefits could improve outcomes. We characterized the pharmacodynamics of a novel dual-antiplatelet-therapy regimen consisting of very-low-dose twice-daily (BD) aspirin with standard-dose ticagrelor. A total of 20 ticagrelor-treated ACS patients entered a randomized crossover to take aspirin 20 mg BD (12-hourly) during one 14-day period and 75 mg once-daily (OD) in the other. Read More

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http://dx.doi.org/10.1080/09537104.2019.1572880DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425913PMC
April 2019
2 Reads

De-escalation versus standard dual antiplatelet therapy in patients undergoing percutaneous coronary intervention: a systematic review and meta-analysis.

Platelets 2019 Feb 13:1-11. Epub 2019 Feb 13.

b Department of Cardiology , The First Hospital of Lanzhou University , Lanzhou , Gansu , China.

Switching from a potent P2Y blocker to clopidogrel is not uncommon for antiplatelet therapy in patients undergoing percutaneous coronary intervention. This meta-analysis aimed to investigate the efficacy and safety of this de-escalation strategy. Medical literature databases were searched for analysis comparing continued potent antiplatelet therapy and switching to clopidogrel with no language restrictions from inception to 07/May/2018. Read More

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http://dx.doi.org/10.1080/09537104.2019.1574969DOI Listing
February 2019
1 Read

The effect of smoking on residual platelet reactivity to clopidogrel: a systematic review and meta-analysis.

Platelets 2019 Feb 11:1-12. Epub 2019 Feb 11.

a Department of Pharmacy , Peking University First Hospital , Beijing , China.

Cigarette smoking is an important cardiovascular risk factor, causing morbidity and mortality. There are many original studies on the impact of smoking, but its influence on platelet ADP-P2Y12 receptor inhibitors lack consistency. Thus, we conducted a systematic review and meta-analysis of already existing data/studies to further explore this issue. Read More

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http://dx.doi.org/10.1080/09537104.2019.1572878DOI Listing
February 2019
7 Reads
2.627 Impact Factor

First line treatment of adult patients with primary immune thrombocytopenia: a real-world study.

Platelets 2019 Feb 11:1-7. Epub 2019 Feb 11.

a Department of Hematology , Qilu Hospital, Shandong University , Jinan , China.

Immune thrombocytopenia (ITP) is an autoimmune disease with a mild to severe risk of bleeding complications. First line treatment includes corticosteroids, immunoglobulins, or other. In this large cohort study, first-line strategies for treatment-naive adult primary ITP was studied in a real-world setting. Read More

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http://dx.doi.org/10.1080/09537104.2019.1572875DOI Listing
February 2019
3 Reads

Preoperative platelet counts and postoperative outcomes in cancer surgery: a multicenter, retrospective cohort study.

Platelets 2019 Feb 11:1-9. Epub 2019 Feb 11.

e Department of Radiation Oncology , Indiana University Health , Indianapolis , IN , USA.

Platelets play roles in malignancy, wound healing, and immunity. Nevertheless, their significance in postoperative outcomes is not established. This is a retrospective cohort study of 100,795 patients undergoing cancer surgery in 2010 and 2014 in >500 hospitals. Read More

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https://www.tandfonline.com/doi/full/10.1080/09537104.2019.1
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http://dx.doi.org/10.1080/09537104.2019.1573977DOI Listing
February 2019
6 Reads

The human platelet transcriptome and proteome is altered and pro-thrombotic functional responses are increased during prolonged hypoxia exposure at high altitude.

Platelets 2019 Feb 5:1-10. Epub 2019 Feb 5.

a Research Center for High Altitude Medicine , Qinghai University , Xining , Qinghai , China.

Exposure to hypoxia, through ascension to high altitudes (HAs), air travel, or human disease, is associated with an increased incidence of thrombosis in some settings. Mechanisms underpinning this increased thrombosis risk remain incompletely understood, and the effects of more sustained hypoxia on the human platelet molecular signature and associated functional responses have never been examined. We examined the effects of prolonged (≥2 months continuously) hypobaric hypoxia on platelets isolated from subjects residing at HA (3,700 meters) and, for comparison, matched subjects residing under normoxia conditions at sea level (50 meters). Read More

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https://www.tandfonline.com/doi/full/10.1080/09537104.2019.1
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http://dx.doi.org/10.1080/09537104.2019.1572876DOI Listing
February 2019
12 Reads

A platelet viability assay (PVA) for the diagnosis of heparin-induced thrombocytopenia.

Platelets 2019 Jan 29:1-5. Epub 2019 Jan 29.

b Department of Medicine, Michael G. DeGroote School of Medicine , McMaster University , Hamilton , Ontario , Canada.

Diagnosing heparin-induced thrombocytopenia (HIT) requires functional assays measuring platelet activation as they are highly specific and sensitive. A useful functional test for diagnosing HIT is the serotonin release assay (SRA), but this assay is technically demanding and requires a radioactive marker. We describe an alternate functional HIT assay, the platelet viability assay (PVA), that overcomes the need for a radioactive marker by using a viability dye endpoint to measure platelet activation. Read More

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http://dx.doi.org/10.1080/09537104.2018.1562169DOI Listing
January 2019
3 Reads

Coexpression network analysis of platelet genes in sickle cell disease.

Platelets 2019 Jan 20:1-8. Epub 2019 Jan 20.

b Department of Blood Transfusion , Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , P. R. China.

Platelets play important roles in vascular health. Activation of platelet may contribute to coagulation and inflammation. Evidence suggests circulating platelets are chronically activated in sickle cell disease (SCD) patients with steady state and further activated in vaso-occlusive crisis. Read More

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http://dx.doi.org/10.1080/09537104.2018.1562170DOI Listing
January 2019
8 Reads

Small GTPases in megakaryocyte and platelet biology.

Platelets 2019 20;30(1):7-8. Epub 2019 Jan 20.

b Department of Biochemistry and Biophysics , University of North Carolina , Chapel Hill , NC , USA.

Review series that provides a state-of-the-art overview of the role of small GTPases in megakaryocyte and platelet biology. While the focus of the reviews is on recent advances in the area of basic science, the clinical relevance of alterations in small GTPase signaling for platelet count and function is also discussed. Read More

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http://dx.doi.org/10.1080/09537104.2018.1560938DOI Listing
March 2019
2 Reads

Favorable effect of glycoprotein IIbIIIa inhibitors among STEMI patients treated with primary PCI and incomplete ST resolution.

Platelets 2019 Jan 20:1-7. Epub 2019 Jan 20.

d Division of Cardiology , IRCCS Multimedica , Sesto San Giovanni (MI) , Italy.

Incomplete ST resolution after primary percutaneous coronary interventions (pPCI) in STEMI patients is a well known prognostic marker, associated with the occurrence of microvascular obstruction and increased mortality. The effects of the use of glycoprotein IIbIIIa inhibitors (GPIs) in this peculiar subset of high- risk patients is still unknown. The aim of the present study was to assess whether the GPIs administration would result in improved outcome in ST elevation myocardial infarction (STEMI) patients with incomplete ST resolution (ISTR). Read More

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http://dx.doi.org/10.1080/09537104.2018.1562171DOI Listing
January 2019
4 Reads

Circulating antiplatelet antibodies in pregnant women with immune thrombocytopenic purpura as predictors of thrombocytopenia in the newborns.

Platelets 2019 Jan 7:1-5. Epub 2019 Jan 7.

a National Medical Research Center for Cardiology , Ministry of Health , Moscow , Russian Federation.

Newborns from mothers with immune thrombocytopenic purpura (ITP) have a risk of thrombocytopenia due to passage of maternal antiplatelet antibodies into fetal/neonatal circulation. We looked for predictors of neonatal thrombocytopenia (nTP) in pregnant women with ITP. One hundred pregnant women with platelet count <100 × 10/l, no non-immune causes of thrombocytopenia and increased platelet associated IgG (PA-IgG) were included in the study. Read More

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https://www.tandfonline.com/doi/full/10.1080/09537104.2018.1
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http://dx.doi.org/10.1080/09537104.2018.1557615DOI Listing
January 2019
14 Reads

Impact of platelet reactivity on long-term prognosis in Korean patients receiving percutaneous coronary intervention.

Platelets 2019 Jan 2:1-6. Epub 2019 Jan 2.

a Department of Internal Medicine , St. Vincent's Hospital, The Catholic University of Korea , Suwon , South Korea.

Both high and low platelet responses to clopidogrel are highly associated with mortality. A therapeutic window for platelet reactivity was recently determined to be an important factor for improving clinical outcomes after percutaneous coronary intervention (PCI). We evaluated the impact of the antiplatelet activity of clopidogrel on long-term clinical outcomes in Korean patients receiving PCI. Read More

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http://dx.doi.org/10.1080/09537104.2018.1562172DOI Listing
January 2019
2 Reads

Rapid testing of red blood cells, white blood cells and platelets in intensive care patients using the HemoScreen™ point-of-care analyzer.

Platelets 2018 Dec 28:1-4. Epub 2018 Dec 28.

c CIRRUS, Hedenstierna laboratory, Anaesthesiology and Intensive care, Department of Surgical Sciences, Anesthesiology , Uppsala University , Uppsala , Sweden.

Acute major bleeding is a condition that can be encountered in critically ill patients and may require rapid transfusions. To evaluate the need for packed red blood cells (RBCs) and platelets (PLTs), it is important to have rapid test results for RBC/hemoglobin and PLTs. Recently, PixCell Medical (Yokneam Ilit, Israel) introduced the HemoScreen™, an automated hematology analyzer. Read More

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https://www.tandfonline.com/doi/full/10.1080/09537104.2018.1
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http://dx.doi.org/10.1080/09537104.2018.1557619DOI Listing
December 2018
6 Reads

Randomized controlled trial protocol to investigate the antiplatelet therapy effect on extracellular vesicles (AFFECT EV) in acute myocardial infarction.

Platelets 2018 Dec 26:1-7. Epub 2018 Dec 26.

a 1st Chair and Department of Cardiology , Medical University of Warsaw , Warsaw , Poland.

Activated platelets contribute to thrombosis and inflammation by the release of extracellular vesicles (EVs) exposing P-selectin, phosphatidylserine (PS) and fibrinogen. P2Y12 receptor antagonists are routinely administered to inhibit platelet activation in patients after acute myocardial infarction (AMI), being a combined antithrombotic and anti-inflammatory therapy. The more potent P2Y12 antagonist ticagrelor improves cardiovascular outcome in patients after AMI compared to the less potent clopidogrel, suggesting that greater inhibition of platelet aggregation is associated with better prognosis. Read More

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http://dx.doi.org/10.1080/09537104.2018.1557616DOI Listing
December 2018
3 Reads

The influence of hypoxia on platelet function and plasmatic coagulation during systemic inflammation in humans in vivo.

Platelets 2018 Dec 25:1-4. Epub 2018 Dec 25.

a Department of Intensive Care Medicine , Radboud University Medical Center , Nijmegen , The Netherlands.

Systemic inflammation and hypoxia frequently occur simultaneously in critically ill patients, and are both associated with platelet activation and coagulopathy. However, human in vivo data on the effects of hypoxia on platelet function and plasmatic coagulation under systemic inflammatory conditions are lacking. In the present study, 20 healthy male volunteers were randomized to either 3. Read More

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http://dx.doi.org/10.1080/09537104.2018.1557617DOI Listing
December 2018
5 Reads

Arachidonic acid causes lysis of blood cells and ADP-dependent platelet activation responses in platelet function tests.

Authors:
Sofia Ramström

Platelets 2018 Dec 24:1-7. Epub 2018 Dec 24.

a Department of Clinical Chemistry and Department of Clinical and Experimental Medicine , Linköping University , Linköping , Sweden.

The use of arachidonic acid (AA) to stimulate platelets is considered as a specific approach to study aspirin treatment efficacy. However, very high concentrations of AA are used, and it has been previously reported that AA can induce cell lysis in other settings. Several clinical studies have reported decreased responses to AA in whole blood tests in the presence of clopidogrel. Read More

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https://www.tandfonline.com/doi/full/10.1080/09537104.2018.1
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http://dx.doi.org/10.1080/09537104.2018.1557614DOI Listing
December 2018
14 Reads

A novel recombinant human thrombopoietin for treating prolonged isolated thrombocytopenia after allogeneic stem cell transplantation.

Platelets 2018 Dec 20:1-7. Epub 2018 Dec 20.

a Peking University People's Hospital, Peking University Institute of Haematology, Beijing Key Laboratory of Haematopoietic Stem Cell Transplantation for the Treatment of Haematological Diseases , Beijing , P.R. China.

Patients with prolonged isolated thrombocytopenia (PT) after allogeneic stem cell transplantation (allo-SCT) are known to have a poor prognosis. However, there is no standard treatment for PT. The present study aimed to investigate the potential effect of a novel recombinant human thrombopoietin (rhTPO) in a cohort of patients with PT following allo-SCT. Read More

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https://www.tandfonline.com/doi/full/10.1080/09537104.2018.1
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http://dx.doi.org/10.1080/09537104.2018.1557613DOI Listing
December 2018
14 Reads

The impact of rivaroxaban on primary hemostasis in patients with venous thrombosis.

Platelets 2018 Dec 20:1-5. Epub 2018 Dec 20.

b Department of Hematology , Oslo University Hospital , Oslo , Norway.

Factor Xa inhibitors are safe and effective alternatives to warfarin, but several studies indicate that rivaroxaban may cause a different risk profile for bleeding. For instance, while the risk of major bleeding in general may be lower with rivaroxaban than for warfarin, the risk of gastrointestinal bleeding or abnormal uterine bleeding may be higher. The underlying mechanisms for these differences are not known, and the effect of rivaroxaban on primary hemostasis is poorly understood. Read More

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http://dx.doi.org/10.1080/09537104.2018.1557618DOI Listing
December 2018
3 Reads

Protease-activated receptor 4 activity promotes platelet granule release and platelet-leukocyte interactions.

Platelets 2019 18;30(1):126-135. Epub 2018 Dec 18.

a Department of Biomedical Engineering , School of Medicine, Oregon Health & Science University , Portland , OR , USA.

Human platelets express two protease-activated receptors (PARs), PAR1 (F2R) and PAR4 (F2RL3), which are activated by a number of serine proteases that are generated during pathological events and cause platelet activation. Recent interest has focused on PAR4 as a therapeutic target, given PAR4 seems to promote experimental thrombosis and procoagulant microparticle formation, without a broadly apparent role in hemostasis. However, it is not yet known whether PAR4 activity plays a role in platelet-leukocyte interactions, which are thought to contribute to both thrombosis and acute or chronic thrombo-inflammatory processes. Read More

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https://www.tandfonline.com/doi/full/10.1080/09537104.2017.1
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http://dx.doi.org/10.1080/09537104.2017.1406076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397092PMC
March 2019
15 Reads

Investigation of the contribution of an underlying platelet defect in women with unexplained heavy menstrual bleeding.

Platelets 2019 6;30(1):56-65. Epub 2018 Dec 6.

b Institute of Cardiovascular Sciences, College of Medical and Dental Sciences , University of Birmingham , Birmingham , UK.

Heavy menstrual bleeding (HMB) is often undiagnosed in women and can cause discomfort and distress. A haemostatic cause for excessive bleeding is often not routinely investigated and can lead to hysterectomy at an early age. A prospective cohort study was carried out to determine whether certain patients with unexplained HMB have an underlying platelet function defect (PFD). Read More

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https://www.tandfonline.com/doi/full/10.1080/09537104.2018.1
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http://dx.doi.org/10.1080/09537104.2018.1543865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406209PMC
March 2019
15 Reads

Platelet reactivity in patients with chronic kidney disease undergoing percutaneous coronary intervention.

Platelets 2018 Dec 5:1-7. Epub 2018 Dec 5.

a Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases , The Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China.

This study aimed to evaluate the platelet reactivity in real-world patients with different chronic kidney disease (CKD) stages after percutaneous coronary intervention (PCI), and to examine whether high residual platelet reactivity (HRPR) is associated with higher incidence of adverse cardiovascular events in a 2-year follow up. A total of 10 724 consecutive patients receiving DAPT with aspirin and clopidogrel after PCI throughout 2013 were enrolled. We applied modified thromboelastography (mTEG) in 6745 patients. Read More

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http://dx.doi.org/10.1080/09537104.2018.1549319DOI Listing
December 2018
2 Reads

Comparison of treatments for persistent/chronic immune thrombocytopenia: a systematic review and network meta-analysis.

Platelets 2018 Dec 3:1-11. Epub 2018 Dec 3.

a Department of Hematology and Oncology , Graduate School of Medicine, Kyoto University , Kyoto , Japan.

Recent studies have indicated that medical options without splenectomy, such as rituximab (RTX) or thrombopoietin receptor agonists (TPO-RAs), can be effective to treat persistent or chronic primary immune thrombocytopenia (ITP). However, it remains to be determined which of these strategies should be the first choice after the first-line treatment for newly diagnosed ITP. We performed a systematic review and network meta-analysis to establish a clinically meaningful hierarchy of the efficacy and safety of medical treatments for persistent or chronic ITP in adults. Read More

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https://www.tandfonline.com/doi/full/10.1080/09537104.2018.1
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http://dx.doi.org/10.1080/09537104.2018.1543864DOI Listing
December 2018
19 Reads

Platelets - the second growth cycle.

Platelets 2019 4;30(1). Epub 2018 Dec 4.

c University of Birmingham , UK.

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http://dx.doi.org/10.1080/09537104.2019.1549810DOI Listing
March 2019
8 Reads

Does plateletpheresis induce a hypercoagulable state? A global assessment of donor's hemostatic system by ROTEM.

Platelets 2018 Nov 29:1-5. Epub 2018 Nov 29.

c Department of Biostatistics , Eskişehir Osmangazi University Medical School , Eskisehir , Turkey.

Since there is still debate on the effects of plateletpheresis on coagulation system, we aimed to perform a global assessment of donor's hemostatic function undergoing plateletpheresis by rotation thromboelastometry (ROTEM) analysis and to clarify if plateletpheresis procedure induces a hypercoagulable state. Thirty male plateletpheresis donors were included in the study. Four blood samples were drawn at different time intervals: before the beginning of the apheresis procedure; immediately after the completion of the apheresis procedure; 24 h and 7 days after the apheresis procedure. Read More

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http://dx.doi.org/10.1080/09537104.2018.1542126DOI Listing
November 2018
4 Reads

Clinical value of the quantitation of average daily platelet increase during the recovery period in childhood acute lymphoblastic leukaemia.

Platelets 2018 Nov 29:1-4. Epub 2018 Nov 29.

b Pediatric department of Hematology, Key Laboratory of Birth Defects and Related Diseases of Women and Children , Sichuan University , Chengdu , Sichuan , P.R. China.

The time to platelet recovery (TPR) is becoming a predicting factor during the treatment of childhood acute leukaemia. However, the initial pre-treatment platelet count (PPC) could interfere with TPR. Here, we integrated both TPR and PPC as the average daily platelet amount increase (Ap) to predict the prognosis in childhood B-ALL during the recovery period. Read More

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http://dx.doi.org/10.1080/09537104.2018.1548011DOI Listing
November 2018
2 Reads
2.627 Impact Factor

ABO antigen levels on platelets of normal and variant ABO blood group individuals.

Platelets 2018 Nov 26:1-7. Epub 2018 Nov 26.

a Blood Center of Zhejiang Province , Hangzhou , China.

Although differential expression of ABO antigens on platelets is related to recipients' platelet recovery and neonatal alloimmune thrombocytopenia in ABO-incompatible transfusion and pregnancy, the expression of ABO antigens on platelets in normal and variant ABO blood group individuals is rarely reported. Here, we analyzed the expression of ABO antigens on platelets in a cohort of 515 individuals with normal and variant ABO. The variants were also genotyped for ABO and/or FUT1 loci to distinguish inherited or acquired ABO variants. Read More

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http://dx.doi.org/10.1080/09537104.2018.1543863DOI Listing
November 2018
6 Reads

Of platelets and aggregometers: personal reminiscences of Gus Born (1921-2018).

Authors:
Rod J Flower

Platelets 2018 Dec 26;29(8):749-755. Epub 2018 Nov 26.

a The William Harvey Research Institute , Queen Mary University of London , London , UK.

This paper recounts the author's personal reminiscences of the late Gustav Born and details some of his major influences on the field of platelet biology and mechanisms of hemostasis. In particular, it focuses on his development of the 'Born aggregometer' and the differences that are seen in the aggregation response to certain stimuli when aggregation is recorded using other techniques such as the impedance method. Read More

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http://dx.doi.org/10.1080/09537104.2018.1533740DOI Listing
December 2018
2 Reads

CYCS gene variants associated with thrombocytopenia.

Platelets 2018 Nov 19:1-3. Epub 2018 Nov 19.

b Department of Pathology, Dunedin School of Medicine , University of Otago , Dunedin , New Zealand.

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http://dx.doi.org/10.1080/09537104.2018.1543866DOI Listing
November 2018
2 Reads

Impact of immature platelet fraction on platelet reactivity during prasugrel maintenance treatment.

Platelets 2018 Nov 13:1-8. Epub 2018 Nov 13.

a Division of Cardiology , Azienda Ospedaliera-Universitaria "Maggiore della Carità", Eastern Piedmont University, Novara, Italy.

Residual high on-treatment platelet reactivity (HTPR) despite dual antiplatelet therapy (DAPT) has emerged as a predictor of major ischemic events in patients undergoing percutaneous coronary interventions (PCIs), especially after an acute cardiovascular event. However, its determinants are still poorly defined. Therefore, the aim of the present study was to evaluate the role of the percentage of reticulated platelets on HTPR in patients on DAPT with ASA (100-160 mg) and prasugrel (10 mg). Read More

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https://www.tandfonline.com/doi/full/10.1080/09537104.2018.1
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http://dx.doi.org/10.1080/09537104.2018.1535707DOI Listing
November 2018
15 Reads