71,322 results match your criteria Platelet Disorders


Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction.

Nat Med 2019 Jan 14. Epub 2019 Jan 14.

Department of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Vascular contributions to cognitive impairment are increasingly recognized as shown by neuropathological, neuroimaging, and cerebrospinal fluid biomarker studies. Moreover, small vessel disease of the brain has been estimated to contribute to approximately 50% of all dementias worldwide, including those caused by Alzheimer's disease (AD). Vascular changes in AD have been typically attributed to the vasoactive and/or vasculotoxic effects of amyloid-β (Aβ), and more recently tau. Read More

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http://dx.doi.org/10.1038/s41591-018-0297-yDOI Listing
January 2019

Thromboinflammation: Challenges of Therapeutically Targeting Coagulation and other Host Defence Mechanisms.

Blood 2019 Jan 14. Epub 2019 Jan 14.

Charles Perkins Centre, The University of Sydney, Camperdown, NSW, Australia.

Thrombosis with associated inflammation (thromboinflammation) occurs commonly in a broad range of human disorders. It is well recognized clinically in the context of superficial thrombophlebitis (thrombosis and inflammation of superficial veins), however it is more dangerous when it develops in the microvasculature of injured tissues and organs. Microvascular thrombosis with associated inflammation is well recognized in the context of sepsis and ischemia-reperfusion injury, however it also occurs in organ transplant rejection, major trauma, severe burns, the antiphospholipid syndrome, preeclampsia, sickle cell disease and biomaterial-induced thromboinflammation. Read More

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http://dx.doi.org/10.1182/blood-2018-11-882993DOI Listing
January 2019

Platelet-Rich Plasma in Treatment of Temporomandibular Joint Dysfunctions: Narrative Review.

Int J Mol Sci 2019 Jan 11;20(2). Epub 2019 Jan 11.

Department of Surgery, Dentistry, Paediatric and Gynaecology, University of Verona. Policlinico G. B. Rossi. Piazzale L. Scuro n.10, 37134 Verona, Italy.

Background: The aims of this narrative review were to examine up-to-date literature in order to evaluate the effectiveness of arthrocentesis or injections with platelet-rich plasma in temporomandibular affections and to compare them to arthrocentesis alone or with hyaluronic acid (HA) or to hyaluronic acid injections.

Methods: The search of international literature was made on the PMC, PubMed and Cochrane databases, including all full-length text of studies on humans focused on osteoarthritis and disc displacements and their treatment with platelet-rich plasma arthrocentesis or injections. All design studies were included in the review and they were examined for three different outcomes: pain, joint sound and mandibular motion. Read More

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http://dx.doi.org/10.3390/ijms20020277DOI Listing
January 2019

The morphofunctional features of platelets against the background of metabolic syndrome in patients with generalized marginal periodontitis.

Diabetes Metab Syndr 2019 Jan - Feb;13(1):730-733. Epub 2018 Dec 3.

I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Department of Operative Surgery and Topographic Anatomy, Moscow, Russia.

According to modern ideas, disorders in the system of hemostasis in cardiovascular diseases are mainly due to an increase in the functional activity of platelets, namely their increased ability to adhere and aggregate. Aim of the research was to evaluate morphofunctional platelets of patients with marginal periodontitis. Material and methods of the study involved 129 men aged 28-50 years (mean age 42. Read More

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http://dx.doi.org/10.1016/j.dsx.2018.11.057DOI Listing
December 2018

A Randomized Double-Blind Placebo Controlled Trial of Autologous Platelet Rich Plasma Intradermal Injections for the Treatment of Vulvar Lichen Sclerosus.

J Am Acad Dermatol 2019 Jan 10. Epub 2019 Jan 10.

Rutgers New Jersey Medical School, Departments of Pathology and Laboratory Medicine, Department Obstetrics, Gynecology, and Women's Health.

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http://dx.doi.org/10.1016/j.jaad.2018.12.060DOI Listing
January 2019

Incidence and Outcome of Severe and Nonsevere Thrombocytopenia Associated With Zika Virus Infection-Puerto Rico, 2016.

Open Forum Infect Dis 2019 Jan 3;6(1):ofy325. Epub 2018 Dec 3.

United States Public Health Service, Silver Springs, Maryland.

Background: Zika virus (ZIKV) infection has been associated with severe thrombocytopenia. We describe the incidence, clinical manifestations, and outcomes of patients with ZIKV infection and thrombocytopenia.

Methods: We reviewed medical records of patients with ZIKV infection and thrombocytopenia (platelet count <100 ×10 cells/L) in Puerto Rico during 2016. Read More

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http://dx.doi.org/10.1093/ofid/ofy325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324556PMC
January 2019

Evaluation of Immunomodulatory and Hematologic Cell Outcome in Heroin/Opioid Addicts.

J Addict 2018 9;2018:2036145. Epub 2018 Dec 9.

Department of Psychiatry, Faculty of Medicine, Sakarya University, 54100 Sakarya, Turkey.

The long-term use of opioids leads alternations in both innate-adaptive immune systems and other diagnostic hematologic cells. The purpose of this study is to evaluate the alterations of these parameters in patients with heroin/opioid addictions. Adults, meeting the Fifth Edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria of the American Psychiatric Association regarding opioid use disorder (Heroin Group or HG, n = 51) and healthy controls (Control Group or CG, n = 50), were included in the study. Read More

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http://dx.doi.org/10.1155/2018/2036145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304569PMC
December 2018

Female pattern hair loss: A clinical, pathophysiologic, and therapeutic review.

Int J Womens Dermatol 2018 Dec 19;4(4):203-211. Epub 2018 Jun 19.

Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Napoli, Italy.

Female pattern hair loss (FPHL) is the most common form of alopecia in women. Affected women may experience psychological distress and impaired social functioning. Early diagnosis and initiation of treatment are desirable because treatments are more effective to avoid the progression of hair loss than stimulating regrowth. Read More

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http://dx.doi.org/10.1016/j.ijwd.2018.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322157PMC
December 2018

Human adenovirus type 7 infection causes a more severe disease than type 3.

BMC Infect Dis 2019 Jan 9;19(1):36. Epub 2019 Jan 9.

Department of Respiratory Medicine, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.

Background: Human adenovirus type 3 (HAdV-3) and 7 (HAdV-7) cause significant morbidity and develop severe complications and long-term pulmonary sequelae in children. However, epidemiologic reports have suggested that nearly all highly severe or fatal adenoviral diseases in children are associated with HAdV-7 rather than HAdV-3. Here, we conduct in-depth investigations to confirm and extend these findings through a comprehensive series of assays in vitro and in vivo as well as clinical correlates. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-018-3651-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327436PMC
January 2019
1 Read

Mean platelet component and mean platelet volume as useful screening markers for myelodysplastic syndrome.

Health Sci Rep 2018 May 2;1(5):e50. Epub 2018 May 2.

Department of Central Clinical Laboratory Osaka Medical College Hospital Takatsuki Osaka Japan.

Background: Hematologic disorders, including myelodysplastic syndrome (MDS), are difficult to identify in routine hematologic examinations using automated hematology analyzers. However, the practical uses of mean platelet component and mean platelet volume (MPV) measured by these analyzers as screening markers for MDS, remain unclear.

Methods: Mean platelet component and MPV values were measured in the peripheral blood of patients with MDS, aplastic anemia, idiopathic thrombocytopenic purpura, myeloproliferative neoplasms, and in healthy controls using an automated hematologic analyzer. Read More

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http://dx.doi.org/10.1002/hsr2.50DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266360PMC

Dual Anticoagulant/Antiplatelet Activity of Polyphenolic Grape Seeds Extract.

Nutrients 2019 Jan 5;11(1). Epub 2019 Jan 5.

Department of Haemostasis and Haemostatic Disorders, Medical University of Lodz, Poland, Mazowiecka 6/8, 92-215 Lodz, Poland.

Because of the side-effects of commonly used anti-platelet and anticoagulant drugs, investigations into plant substances with similar activities are very common. Based on our own studies in recent years, we estimate that it is possible to use natural compounds to both inhibit coagulation pathway enzymes and to reduce blood platelets' activation. As such, in our current study we wanted to verify the anti-platelet and anticoagulant properties of grape seed extract (GSE) using in vitro models. Read More

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http://dx.doi.org/10.3390/nu11010093DOI Listing
January 2019
2 Reads

Large Extracellular Vesicles: Have We Found the Holy Grail of Inflammation?

Front Immunol 2018 13;9:2723. Epub 2018 Dec 13.

Department of Oncology, Hematology and Rheumatology, University Hospital Bonn, Bonn, Germany.

The terms microparticles (MPs) and microvesicles (MVs) refer to large extracellular vesicles (EVs) generated from a broad spectrum of cells upon its activation or death by apoptosis. The unique surface antigens of MPs/MVs allow for the identification of their cellular origin as well as its functional characterization. Two basic aspects of MP/MV functions in physiology and pathological conditions are widely considered. Read More

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http://dx.doi.org/10.3389/fimmu.2018.02723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300519PMC
December 2018

Red blood cells: the forgotten player in hemostasis and thrombosis.

J Thromb Haemost 2019 Jan 7. Epub 2019 Jan 7.

Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

New evidence has stirred up a long-standing but undeservedly forgotten interest in the role of erythrocytes, or red blood cells (RBCs), in blood clotting and its disorders. This review summarizes the most recent research that describes the involvement of RBCs in hemostasis and thrombosis. There are both quantitative and qualitative changes in RBCs that affect bleeding and thrombosis, as well as interactions of RBCs with cellular and molecular components of the hemostatic system. Read More

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http://dx.doi.org/10.1111/jth.14360DOI Listing
January 2019

Diagnosis of hereditary platelet disorders in the era of next-generation sequencing:"primum non nocere".

J Thromb Haemost 2019 Jan 5. Epub 2019 Jan 5.

Institut für Immunologie und Transfusionsmedizin, Universitätsmedizin Greifswald, Greifswald, Germany.

Inherited platelet disorders can affect "only platelets", occur as a "syndromic phenotype", or be associated with "increased risk for hematological malignancies". Genetic testing is attractive for diagnoses of inherited platelet disorders. However, many physicians who refer patient blood for genetic testing are unaware of the association of certain inherited platelet disorders with other risks. Read More

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http://doi.wiley.com/10.1111/jth.14377
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http://dx.doi.org/10.1111/jth.14377DOI Listing
January 2019
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The use of unlicensed bone marrow-derived platelet lysate-expanded mesenchymal stromal cells in colitis: a pre-clinical study.

Cytotherapy 2019 Jan 2. Epub 2019 Jan 2.

Advanced Cell Therapy Centre, Finnish Red Cross Blood Service, Helsinki, Finland. Electronic address:

Background: Mesenchymal stromal cells (MSCs) are a promising candidate for treatment of inflammatory disorders, but their efficacy in human inflammatory bowel diseases (IBDs) has been inconsistent. Comparing the results from various pre-clinical and clinical IBD studies is also challenging due to a large variation in study designs.

Methods: In this comparative pre-clinical study, we compared two administration routes and investigated the safety and feasibility of both fresh and cryopreserved platelet-lysate-expanded human bone marrow-derived MSCs without additional licensing in a dextran sodium sulfate (DSS) colitis mouse model both in the acute and regenerative phases of colitis. Read More

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http://dx.doi.org/10.1016/j.jcyt.2018.11.011DOI Listing
January 2019

Editorial Commentary: Biologic Products for Cartilage Regeneration-Time to Redefine the Rules of the Game?

Arthroscopy 2019 Jan;35(1):260-261

Humanitas University and Humanitas Clinical and Research Center, Rozzano - Milan, Italy.

The use of biological strategies to treat cartilage disorders has become popular in the past 20 years: The real explosion occurred with the introduction of platelet-rich plasma into clinical practice, and from that moment onward, a huge number of "biologic products" invaded the market, taking advantage of a confusing regulatory environment. Such an abundance is actually not backed up by solid clinical data to support the safety and efficacy of these products. This "gold rush" for biologics could soon produce dangerous effects if neglected by physicians and competent authorities. Read More

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http://dx.doi.org/10.1016/j.arthro.2018.07.017DOI Listing
January 2019
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Editorial Commentary: Platelet-Rich Plasma Details Are Critical to Outcome…Catching Is Always Better Than Fishing.

Arthroscopy 2019 Jan;35(1):211-213

Santa Monica, California.

The use of platelet-rich plasma (PRP) and the spectrum of orthobiological interventions has been a major innovation in orthopedic surgery and medicine. Biological-based therapies for musculoskeletal disorders and injuries have gained popularity in the past decade and created significant expectation as the future of sports medicine, based on theoretical advantages including minimal invasiveness, greater healing potential, faster recovery, and a less expensive alternative to surgery. These therapies for musculoskeletal intervention include PRP, bone marrow aspirate concentrate, cellular-based therapies, and tissue engineering. Read More

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http://dx.doi.org/10.1016/j.arthro.2018.09.004DOI Listing
January 2019

Novel EZH2 mutation in a patient with secondary B-cell acute lymphocytic leukemia after deletion 5q myelodysplastic syndrome treated with lenalidomide: A case report.

Medicine (Baltimore) 2019 Jan;98(1):e14011

FUNDALEU, Buenos Aires, Argentina.

Rationale: The gene deletion (5)(q22q35) is reported in 10-20% of myelodysplastic syndrome (MDS) cases and is associated with response to lenalidomide and favorable prognosis. The authors report here a clinical case of MDS transformation to B-cell acute lymphocytic leukemia (B-ALL) with an associated accrual of an additional mutation following treatment with lenalidomide.

Patient Concerns: A 69-year-old man presented with progressive anemia, normal white blood cell count, and thrombocytopenia consistent with MDS. Read More

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http://dx.doi.org/10.1097/MD.0000000000014011DOI Listing
January 2019
1 Read
5.723 Impact Factor

Congenital internal carotid artery hypoplasia: Case report.

Medicine (Baltimore) 2019 Jan;98(1):e13986

Department of Neurology.

Rationale: Congenital internal carotid artery hypoplasia (CICAH) is rarely reported. This study aimed to discuss the epidemiological characteristics, clinical manifestation, imaging and treatment of CICAH.

Patient Concerns: The case was male who showed barylalia and limited abilities of the left limbs as their main clinical manifestation. Read More

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http://dx.doi.org/10.1097/MD.0000000000013986DOI Listing
January 2019

Agranulocytosis-Protective Olanzapine-Loaded Nanostructured Lipid Carriers Engineered for CNS Delivery: Optimization and Hematological Toxicity Studies.

AAPS PharmSciTech 2019 Jan 2;20(1):22. Epub 2019 Jan 2.

Department of Pharmaceutics, Sinhgad Institute of Pharmacy, Sinhgad Technical Education Society, Narhe, Pune, MS, 411041, India.

Potential risk of agranulocytosis is one of the drug-induced adverse effects of the second-generation antipsychotic agents. The present investigation aimed to formulate and investigate olanzapine (OLZ)-loaded nanostructured lipid carriers (OLZ-NLCs) via intranasal (i.n. Read More

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http://dx.doi.org/10.1208/s12249-018-1213-yDOI Listing
January 2019

A Case of Chronic Myelogenous Leukemia Occurring in a Patient Treated for Essential Thrombocythemia.

Am J Case Rep 2019 Jan 3;20:10-14. Epub 2019 Jan 3.

Department of Hematology and Medical Oncology, Emory University, Atlanta, GA, USA.

BACKGROUND Essential thrombocythemia (ET) is one of the BCR-ABL gene fusion negative chronic myeloproliferative disorders (MPDs), which also include polycythemia vera (PV), and myelofibrosis. Few clinical cases have reported the progression of ET to chronic myelogenous leukemia (CML) with the expression of the BCR-ABL gene. This report describes such a case and includes a review of other reported cases of CML co-occurring with BCR-ABL-negative chronic MPDs. Read More

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http://dx.doi.org/10.12659/AJCR.911854DOI Listing
January 2019
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Increased RhoA activity due to a disrupted filamin A/αβ interaction induces macrothrombocytopenia.

Blood 2019 Jan 2. Epub 2019 Jan 2.

UMR 1170, Institut National de la Sante et de la Recherche Medicale, Univ. Paris-Sud, Universite Paris-Saclay, Equipe Labellisee Ligue Nationale Contre le Cancer, Villejuif, France;

Filamin A (FLNa) links the cell membrane with the cytoskeleton and is central in several cellular processes. Heterozygous mutations in the X-linked gene are associated with a large spectrum of conditions called filaminopathies that include macrothrombocytopenia. Here we show, using an isogenic pluripotent stem cell model derived from patients, that the absence of the FLNa protein in megakaryocytes (MKs) leads to their incomplete maturation, and particularly the inability to produce proplatelets. Read More

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http://dx.doi.org/10.1182/blood-2018-07-861427DOI Listing
January 2019
1 Read

A CBC algorithm combined with immature platelet fraction is able to identify JAK2 V617F mutation-positive polycythaemia vera patients.

Int J Lab Hematol 2019 Jan 2. Epub 2019 Jan 2.

Haematology Laboratory, Medlab Central, Palmerston North Hospital, Palmerston North, New Zealand.

Introduction: The recent lowering of the World Health Organisation (WHO) haemoglobin (Hb) and haematocrit (HCT) thresholds for diagnosis of polycythaemia vera (PV) has markedly increased the proportion of complete blood counts (CBC) that could be referred for haematologist review for comment, including advice on JAK2 V617F mutation analysis. The utility of an algorithm based on CBC indices and immature platelet fraction (IPF) to select cases for haematologist review was investigated.

Methods: IPF analysis was performed on 22 patients with known JAK2 V617F mutation and 41 patients who were negative for this mutation previously tested because of suspicion of PV. Read More

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http://dx.doi.org/10.1111/ijlh.12967DOI Listing
January 2019
1 Read

Functional significance of the platelet immune receptors GPVI and CLEC-2.

J Clin Invest 2019 Jan 2;129(1):12-23. Epub 2019 Jan 2.

Institute of Experimental Biomedicine, University Hospital and Rudolf Virchow Center, University of Würzburg, Würzburg, Germany.

Although platelets are best known for their role in hemostasis, they are also crucial in development, host defense, inflammation, and tissue repair. Many of these roles are regulated by the immune-like receptors glycoprotein VI (GPVI) and C-type lectin receptor 2 (CLEC-2), which signal through an immunoreceptor tyrosine-based activation motif (ITAM). GPVI is activated by collagen in the subendothelial matrix, by fibrin and fibrinogen in the thrombus, and by a remarkable number of other ligands. Read More

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https://www.jci.org/articles/view/122955
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http://dx.doi.org/10.1172/JCI122955DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307936PMC
January 2019
6 Reads

Bone Marrow Morphology Associated With Germline RUNX1 Mutations in Patients With Familial Platelet Disorder With Associated Myeloid Malignancy.

Pediatr Dev Pathol 2019 Jan 2:1093526618822108. Epub 2019 Jan 2.

9 Division of Hematology Oncology, Boston Children's Hospital, Boston, Massachusetts.

Germline mutations in RUNX1 result in autosomal dominant familial platelet disorder with associated myeloid malignancy (FPDMM). To characterize the hematopathologic features associated with a germline RUNX1 mutation, we reviewed a total of 42 bone marrow aspirates from 14 FPDMM patients, including 24 cases with no cytogenetic clonal abnormalities, and 18 with clonal karyotypes or leukemia. We found that all aspirate smears had ≥10% atypical megakaryocytes, predominantly characterized by small forms with hypolobated and eccentric nuclei, and forms with high nuclear-to-cytoplasmic ratios. Read More

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http://dx.doi.org/10.1177/1093526618822108DOI Listing
January 2019
4 Reads

Alteration in Prooxidant-antioxidant Balance Associated with Selenium Concentration in Patients with Congenital Hypothyroidism.

J Med Biochem 2018 Jul 1;37(3):355-363. Epub 2018 Jul 1.

Food and drugs control laboratory, Vice-chancellery for food and drugs, Kurdistan University of Medical Sciences, Sanandaj, Iran.

Background: There is a paucity of studies regarding oxidative balance and selenium (Se) status in congenital hypothyroidism. Recently, more attention has been given to the use of Se supplementation as a new treatment for thyroid disorders. Oxidative stress increases in different thyroid disorders and causes many pathological outcomes. Read More

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http://dx.doi.org/10.1515/jomb-2017-0052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298467PMC

PF-04447943, a Phosphodiesterase 9A Inhibitor, in Stable Sickle Cell Disease Patients: A Phase Ib Randomized, Placebo-Controlled Study.

Clin Transl Sci 2018 Dec 31. Epub 2018 Dec 31.

Pfizer, Inc., Cambridge, Massachusetts, USA.

This phase Ib study randomized patients with stable sickle cell disease (SCD) aged 18-65 years to twice-daily PF-04447943 (a phosphodiesterase 9A inhibitor; 5 or 25 mg) or placebo, with/without hydroxyurea coadministration, for up to 29 days. Blood samples were collected at baseline and various posttreatment time points for assessments of PF-04447943 pharmacokinetics (PKs)/pharmacodynamics (PDs). Change from baseline in potential SCD-related biomarkers was evaluated. Read More

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http://dx.doi.org/10.1111/cts.12604DOI Listing
December 2018

The neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in adolescent obsessive-compulsive disorder: Does comorbid anxiety disorder affect inflammatory response?

Psychiatry Res 2018 Dec 25;272:311-315. Epub 2018 Dec 25.

Child and Adolescent Psychiatry Specialist, Child and Adolescent Psychiatry Unit, Behçet Uz Children's Hospital, İzmir, Turkey. Electronic address:

Recent adult etiologic studies indicated evidence linking increased inflammatory parameters with psychiatric disorders. The neutrophil-lymphocyte ratio and platelet-lymphocyte ratio are easily obtainable clinical markers of inflammation and have been found to be increased in various medical and mental disorders. In this study, we aimed to investigate the neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in adolescents with obsessive-compulsive disorder (OCD). Read More

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http://dx.doi.org/10.1016/j.psychres.2018.12.131DOI Listing
December 2018

3-D printing of chitosan-calcium phosphate inks: rheology, interactions and characterization.

J Mater Sci Mater Med 2018 Dec 29;30(1). Epub 2018 Dec 29.

Univ Lyon, INSA Lyon, MATEIS UMR CNRS 5510, Bât. Blaise Pascal, 7 Avenue Jean Capelle, Villeurbanne, France.

Bone substitute fabrication is of interest to meet the worldwide incidence of bone disorders. Physical chitosan hydrogels with intertwined apatite particles were chosen to meet the bio-physical and mechanical properties required by a potential bone substitute. A set up for 3-D printing by robocasting was found adequate to fabricate scaffolds. Read More

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http://dx.doi.org/10.1007/s10856-018-6201-yDOI Listing
December 2018

Thrombocytopenic purpura following envenomation by the nose-horned viper (Vipera ammodytes ammodytes): Two case reports.

Medicine (Baltimore) 2018 Dec;97(52):e13737

Department of Molecular and Biomedical Sciences, Jožef Stefan Institute, Ljubljana, Slovenia.

Rationale: Two clinical cases are reported of envenomation by the nose-horned viper (Vipera ammodytes ammodytes) venom of a 9-year-old boy and of an 84-year-old woman.

Patient Concerns: Both patients had been bitten on their extremities by such a snake in August near Split, a town in southern Croatia.

Diagnoses: Clinical manifestation of envenomation was severe in the case of the boy, being characterized by a severe coagulopathy. Read More

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http://dx.doi.org/10.1097/MD.0000000000013737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314653PMC
December 2018

Micromolar concentrations of citalopram or escitalopram inhibit glycoprotein VI-mediated and integrin αIIbβ3-mediated signaling in human platelets.

Toxicol Appl Pharmacol 2019 Feb 25;364:106-113. Epub 2018 Dec 25.

Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.

Collagen and convulxin induce platelet aggregation through glycoprotein VI (GPVI)-FcRγ-Syk signaling pathway. In addition, fibrinogen induces platelet activation through integrin αIIbβ3-FcγRIIa-Syk signaling pathway. We previously reported that high concentrations of selective serotonin reuptake inhibitors (SSRI) reduce platelet aggregation induced by collagen. Read More

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http://dx.doi.org/10.1016/j.taap.2018.12.016DOI Listing
February 2019

A new form of inherited thrombocytopenia caused by loss-of-function mutations in .

Blood 2018 Dec 27. Epub 2018 Dec 27.

Department of Internal Medicine, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy;

Inherited thrombocytopenias (ITs) are a heterogeneous group of disorders characterized by low platelet count that may result in bleeding tendency. Despite progress being made in defining the genetic causes of ITs, nearly 50% of patients with familial thrombocytopenia are affected with forms of unknown origin. Here, through exome sequencing of two siblings with autosomal recessive thrombocytopenia, we identified two biallelic loss-of-function variants in This gene encodes for a receptor-like protein tyrosine phosphatase, PTPRJ (or CD148), expressed abundantly in platelets and megakaryocytes. Read More

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http://www.bloodjournal.org/lookup/doi/10.1182/blood-2018-07
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http://dx.doi.org/10.1182/blood-2018-07-859496DOI Listing
December 2018
4 Reads

Circulating blood cells and extracellular vesicles in acute cardioprotection.

Cardiovasc Res 2018 Dec 24. Epub 2018 Dec 24.

Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary; Pharmahungary Group, Szeged, Hungary.

During an ST-elevation myocardial infarction (STEMI), the myocardium undergoes a prolonged period of ischaemia. Reperfusion therapy is essential to minimize cardiac injury but can paradoxically cause further damage. Experimental procedures to limit ischaemia and reperfusion (IR) injury have tended to focus on the cardiomyocytes since they are crucial for cardiac function. Read More

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http://dx.doi.org/10.1093/cvr/cvy314DOI Listing
December 2018
3 Reads
5.940 Impact Factor

Differential protein expression of blood platelet components associated with adverse transfusion reactions.

J Proteomics 2018 Dec 24;194:25-36. Epub 2018 Dec 24.

GIMAP-EA3064, University of Lyon, Saint-Etienne, France; French Blood Bank (EFS) Auvergne-Rhône-Alpes, Saint-Etienne, France. Electronic address:

Platelets found within platelet components (PCs) intended for transfusion release inflammatory molecules. Despite the implementation of leukoreduction, some of these PCs are occasionally associated with adverse transfusion reactions (ATRs). The aim of this study was to decipher the platelet proteome in two types of PCs, buffy-coat-derived pooled PCs (PPCs) and single-donor apheresis PCs (SDA-PCs), associated with ATRs. Read More

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http://dx.doi.org/10.1016/j.jprot.2018.12.019DOI Listing
December 2018

Reactive thrombocytosis resulting from frequent blood donations as an extremely rare cause of ST Segment Elevation Myocardial Infarction in the case of a 19-year-old male.

Ann Agric Environ Med 2018 Dec 15;25(4):602-604. Epub 2017 Jul 15.

Chair and Department of Cardiology, Medical University of Lublin.

Introduction: Thrombocytosis is a disease where the platelet count exceeds 600,000/μl. It is usually reactive in nature, less often clonal. Reactive thrombocytosis is usually a response to reactive inflammation or infection, splenectomy, iron deficiency, pregnancy, physical effort or cancer. Read More

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http://dx.doi.org/10.26444/aaem/74196DOI Listing
December 2018
1 Read

Is coagulopathy a common consequence of a Vipera berus bite? A retrospective single centre study.

Ann Agric Environ Med 2018 Dec 16;25(4):630-634. Epub 2017 Oct 16.

First Department of General, Oncological & Gastroenterological Surgery Jagiellonian University Medical College, Cracow, Poland.

Introduction: The Vipera berus (common viper) is the only species of venomous snake found in Poland. The aim of this study was to determine to what extent coagulopathy has occurred as a post-bite complication.

Material And Methods: The medical records of 138 adult patients in the Sucha Beskidzka hospital with the diagnosis of snake bite between 2001-2014 were retrospectively analyzed. Read More

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http://dx.doi.org/10.26444/aaem/75941DOI Listing
December 2018

Blood clot contraction differentially modulates internal and external fibrinolysis.

J Thromb Haemost 2018 Dec 24. Epub 2018 Dec 24.

Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Background: Fibrinolysis involves dissolution of polymeric fibrin networks that is required to restore blood flow through vessels obstructed by thrombi. The efficiency of lysis depends in part on the susceptibility of fibrin to enzymatic digestion, which is governed by the structure and spatial organization of fibrin fibers. How platelet-driven clot contraction affects the efficacy of fibrinolysis has received relatively little study. Read More

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http://dx.doi.org/10.1111/jth.14370DOI Listing
December 2018

Platelets function assessment in patients qualified for cardiac surgery - clinical problems and a newer diagnostic possibilities.

J Cardiothorac Surg 2018 Dec 22;13(1):131. Epub 2018 Dec 22.

Department of Cardiac Surgery, Wroclaw Medical University, Wroclaw, Poland.

Background: As the incidence of cardiovascular diseases increases, the use of antiplatelet therapy is widely recognized. This presents clinicians with the challenge of balancing the risk of thrombotic and bleeding complications. Platelet dysfunction is one of the causes of postoperative bleedings and their etiology is not fully understood. Read More

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http://dx.doi.org/10.1186/s13019-018-0820-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303902PMC
December 2018
3 Reads

Human Platelet Antigens in Brazilian Multiethnic Populations: Occurrence of Regional Variation and Frequency in a Large Urban Center (Belo Horizonte).

Transfus Med Hemother 2018 Nov 11;45(6):388-396. Epub 2018 May 11.

Serviço de Pesquisa, Fundação Centro de Hematologia e Hemoterapia de Minas Gerais, Fundação Hemominas, Belo Horizonte, Brazil.

Background: The frequency of human platelet antigens (HPA) varies according to ethnicity, which causes differences in the morbidity of alloimmune and autoimmune thrombocytopenic disorders in different populations. Studies on HPA frequencies in Brazil have reported differences among Brazilian populations produced by the diverse degrees of admixture throughout the country.

Methods: In the present study, we investigated the variation of HPA distribution in Brazil, compared with worldwide populations, and describe the frequencies of HPA-1, -2, -3, -5, and -15 in a large urban center in Southern Brazil (Belo Horizonte) based on a sample of blood donors. Read More

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http://dx.doi.org/10.1159/000488469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288627PMC
November 2018
2 Reads

Progressive Retinal Findings in Hemolytic Uremic Syndrome.

J Pediatr Ophthalmol Strabismus 2018 Dec 19;55:e49-e51. Epub 2018 Dec 19.

Ocular involvement in hemolytic uremic syndrome is rare and in most cases presents with retinal ischemia, hemorrhages, and neovascularization. The authors describe the progression of retinal involvement as a rare complication of typical hemolytic uremic syndrome in a 2-year-old boy. Progression of retinal findings were demonstrated with serial fundus photographs. Read More

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http://dx.doi.org/10.3928/01913913-20181017-03DOI Listing
December 2018
1 Read

Platelet function assays in diagnosis: an update.

Expert Rev Hematol 2018 Dec 20. Epub 2018 Dec 20.

a Department of Medicine, Section of Internal and Cardiovascular Medicine , University of Perugia , Perugia , Italy.

Introduction: Hemorrhagic diseases associated with platelet dysfunction include inherited platelet function disorders (IPFD) and a large number of non-hereditary conditions, defined as acquired platelet function disorders (APFD). Their identification requires a careful clinical evaluation and a rational use of diagnostic laboratory assays. Areas covered: Here, we describe the laboratory techniques currently available for assessment of platelet function, including new and experimental laboratory assays, and their alterations in platelet function disorders. Read More

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http://dx.doi.org/10.1080/17474086.2019.1562333DOI Listing
December 2018

Ischemic and hemorrhagic brain injury during venoarterial-extracorporeal membrane oxygenation.

Ann Intensive Care 2018 Dec 20;8(1):129. Epub 2018 Dec 20.

Service de Réanimation, Institut de Cardiologie, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, 47, boulevard de l'Hôpital, 75013, Paris, France.

Background: Structural neurological complications (ischemic stroke and intracranial bleeding) and their risk factors in patients receiving venoarterial-extracorporeal membrane oxygenation (VA-ECMO) are poorly described. Our objective was to describe frequencies, outcomes and risk factors for neurological complications (ischemic stroke and intracranial bleeding) in patients receiving VA-ECMO.

Methods: Retrospective observational study conducted, from 2006 to 2014, in a tertiary referral center on patients who developed a neurological complication(s) on VA-ECMO. Read More

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http://dx.doi.org/10.1186/s13613-018-0475-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301905PMC
December 2018
1 Read

Platelet abnormalities in Huntington's disease.

J Neurol Neurosurg Psychiatry 2018 Dec 19. Epub 2018 Dec 19.

Centre de Recherche du CHU de Québec, Québec, QC, Canada

Huntington's disease (HD) is a hereditary disorder that typically manifests in adulthood with a combination of motor, cognitive and psychiatric problems. The pathology is caused by a mutation in the huntingtin gene which results in the production of an abnormal protein, mutant huntingtin (mHtt). This protein is ubiquitously expressed and known to confer toxicity to multiple cell types. Read More

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http://dx.doi.org/10.1136/jnnp-2018-318854DOI Listing
December 2018

Feeling the Force: Measurements of Platelet Contraction and Their Diagnostic Implications.

Semin Thromb Hemost 2018 Dec 19. Epub 2018 Dec 19.

The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia.

In addition to the classical biological and biochemical framework, blood clots can also be considered as active biomaterials composed of dynamically contracting platelets, nascent polymeric fibrin that functions as a matrix scaffold, and entrapped blood cells. As platelets sense, rearrange, and apply forces to the surrounding microenvironment, they dramatically change the material properties of the nascent clot, increasing its stiffness by an order of magnitude. Hence, the mechanical properties of blood clots are intricately tied to the forces applied by individual platelets. Read More

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http://dx.doi.org/10.1055/s-0038-1676315DOI Listing
December 2018

Pharmacokinetics and Pharmacodynamics of an Oral Formulation of Apixaban in Horses After Oral and Intravenous Administration.

Front Vet Sci 2018 4;5:304. Epub 2018 Dec 4.

Department of Population Medicine and Diagnostic Science, College of Veterinary Medicine, Cornell University, Ithaca, NY, United States.

Horses with inflammatory and infectious disorders are often treated with injectable heparin anticoagulants to prevent thrombotic complications. In humans, a new class of direct oral acting anticoagulants (DOAC) appear as effective as heparin, while eliminating the need for daily injections. Our study in horses evaluated apixaban, a newly approved DOAC for human thromboprophylaxis targeting activated factor X (Xa). Read More

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http://dx.doi.org/10.3389/fvets.2018.00304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288471PMC
December 2018

The Role of Advanced Practitioners in Optimizing Clinical Management and Support of Patients With Polycythemia Vera.

J Adv Pract Oncol 2018 Jan-Feb;9(1):56-66. Epub 2018 Jan 1.

The University of Arizona Cancer Center, Tucson, Arizona; and University of Colorado Anschutz Medical Campus, Aurora, Colorado.

Mr. M, a 65-year-old male, presented to his primary care physician with progressive fatigue, difficulty sleeping, and daily headaches for the past 3 weeks. His headaches were not associated with visual disturbances, cognitive deficits, or nausea/vomiting, and he had no history of migraines. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296415PMC
January 2018
1 Read

Diagnostic challenges of inherited mild bleeding disorders: a bait for poorly explored clinical and basic research.

Authors:
D Mezzano T Quiroga

J Thromb Haemost 2018 Dec 18. Epub 2018 Dec 18.

Clinical Laboratory, School of Medicine, Pontificia Universidad Católica de Chile, Chile.

The best known inherited mild bleeding disorders (MBD), type 1 von Willebrand disease, platelet function disorders (PFD) and mild/moderate clotting factor deficiencies, are characterized clinically by mucocutaneous bleeding (MCB) and although highly prevalent, still pose difficult diagnostic problems. These include establishing the pathological nature of bleeding, as well as the uncertainties surrounding the clinical relevance of laboratory results. Furthermore, the high frequency of bleeding symptoms in the normal population and the subjective appraisal of symptoms by patients or parents makes elucidating the pathologic nature of bleeding difficult. Read More

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http://dx.doi.org/10.1111/jth.14363DOI Listing
December 2018

Long-term safety and efficacy of deferasirox in patients with myelodysplastic syndrome, aplastic anemia and other rare anemia in Taiwan.

Hematology 2019 Dec;24(1):247-254

k Department of Internal Medicine , Chung Shan Medical University Hospital , Taichung , Taiwan.

Objective: Patients with myelodysplastic syndromes (MDS), aplastic anemia (AA) or other rare anemia require chronic blood transfusions which can lead to iron overload and subsequent excess iron-mediated complications. Intensive iron chelation with deferasirox could remove excess iron and can alleviate these events; however, the long-term safety and efficacy in Chinese population are not clearly characterized. This study examined the long-term efficacy and safety of deferasirox in a real-world setting in Taiwan. Read More

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http://dx.doi.org/10.1080/16078454.2018.1557860DOI Listing
December 2019
4 Reads