71,674 results match your criteria Platelet Disorders


Synthesis of CC, CN coupled novel substituted dibutyl benzothiazepinone derivatives and evaluation of their thrombin inhibitory activity.

Bioorg Chem 2019 Mar 5;87:142-154. Epub 2019 Mar 5.

Department of Chemistry, Bangalore University, Central College Campus, Palace Road, Bangalore 560001, India; Department of Studies in Organic Chemistry, University of Mysore, Manasagangotri, Mysore 570006, India. Electronic address:

The formation of a thrombus is a key event in thromboembolic disorders, that contribute to high mortality and morbidity in affected patients. In the present study, we synthesized a library of novel substituted 3,3-dibutyl-8-methoxy-2,3-dihydrobenzo [b] [1,4] thiazepin-4(5H)-one derivatives which were tested for their platelet aggregation and thrombin inhibitory activity. Among the tested compounds, 3,3-dibutyl-7-(2-chlorophenyl)-8-methoxy-2,3-dihydrobenzo[b] [1,4]thiazepin-4(5H)-one (DCT) displayed the maximum thrombin inhibition with an IC value of 3. Read More

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http://dx.doi.org/10.1016/j.bioorg.2019.03.004DOI Listing

Noninvasive Predictors of High-Risk Varices in Patients with Non-Cirrhotic Portal Hypertension.

Can J Gastroenterol Hepatol 2019 7;2019:1808797. Epub 2019 Feb 7.

Toronto Centre for Liver Disease, University Hospital Network, Toronto M5G 2C4, Canada.

Non-cirrhotic portal hypertension (NCPH) comprises a heterogeneous group of liver disorders causing portal hypertension without cirrhosis and carries a high risk of variceal bleeding. Recent guidelines, based largely on patients with viral cirrhosis, suggest low likelihood of high risk varices (HRV) in patients with a liver stiffness measurement (LSM) <20 kPa and platelet count >150 × 10/L. In NCPH, LSM is often higher than healthy controls but lower than matched cirrhotic patients. Read More

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http://dx.doi.org/10.1155/2019/1808797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383430PMC
February 2019

A peptide antagonist of F11R/JAM-A reduces plaque formation and prolongs survival in an animal model of atherosclerosis.

Atherosclerosis 2019 Feb 22;284:92-101. Epub 2019 Feb 22.

Department of Medicine, State University of New York, Downstate Medical Center, Brooklyn, NY, 11203, USA.

Background And Aims: The F11 Receptor (F11R), AKA Junctional Adhesion Molecule-A (JAM-A) (F11R/JAM-A), is an adhesion protein constitutively expressed on the membrane surface of circulating platelets and the luminal surface of inflamed endothelial cells (EC). Platelet adhesion to an inflamed endothelium is one of the early steps of atherosclerotic plaque formation. Our previous studies, conducted with cultured EC in vitro, have demonstrated the expression of F11R/JAM-A on the luminal surface of inflamed EC, platelet adhesion to inflamed EC through F11R/JAM-A interactions, and inhibition of this interaction by the presence of F11R/JAM-A antagonistic peptide (F11Rpeptide 4D). Read More

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http://dx.doi.org/10.1016/j.atherosclerosis.2019.02.014DOI Listing
February 2019
1 Read

Antimicrobial, anticoagulant and antiplatelet activities of green synthesized silver nanoparticles using Selaginella (Sanjeevini) plant extract.

Int J Biol Macromol 2019 Mar 12. Epub 2019 Mar 12.

Department of Microbiology, University College of Science, Tumkur University, Tumkur 572103, Karnataka, India. Electronic address:

The recent study deals with the synthesis and characterization of silver nanoparticles bounded to Selaginella bryopteris (Sanjeevini) Plant extract (SPE) as reducing and capping agents. Selaginella bryopteris plant extract silver nanoparticles (SPE@Ag-NPs) was characterized by PXRD, UV-Vis., FESEM, TEM and EDX. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01418130183674
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http://dx.doi.org/10.1016/j.ijbiomac.2019.01.222DOI Listing
March 2019
3 Reads

The Coagulopathy of Acute Type A Aortic Dissection: A Prospective, Observational Study.

J Cardiothorac Vasc Anesth 2019 Feb 11. Epub 2019 Feb 11.

Lund University, Skåne University Hospital, Department of Clinical Sciences, Lund, Department of Cardiothoracic Surgery, Lund, Sweden.

Objective: To evaluate the hemostatic system in patients undergoing surgery for acute type A aortic dissection (ATAAD) compared with those undergoing elective aortic procedures.

Design: This was a prospective, observational study.

Setting: The study was performed at a single university hospital. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10530770193014
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http://dx.doi.org/10.1053/j.jvca.2019.02.013DOI Listing
February 2019
2 Reads

[Glutathione reductase and glutathione-S-transferase in blood cells in schizophrenia and schizophrenia spectrum disorders].

Zh Nevrol Psikhiatr Im S S Korsakova 2019 ;119(2):61-65

Mental Health Research Centre, Moscow, Russia.

Aim: To compare glutathione reductase (GR) and glutathione-S-transferase (GST) enzymatic activities in blood cells (erythrocytes and platelets) of patients with schizophrenia spectrum disorders and in the control group and to search for correlations of these biochemical parameters with clinical psychiatric assessments of the patient.

Material And Methods: The study included patients (97 men) with schizophrenia spectrum disorder (schizophrenia and schizoaffective disorders) in an acute state of exacerbation of psychotic symptoms and 33 men without mental pathology. Symptom severity was measured with the PANSS before and after antipsychotic therapy. Read More

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http://dx.doi.org/10.17116/jnevro201911902161DOI Listing
January 2019
1 Read

First description of an IgM monoclonal antibody causing α β integrin activation and acquired Glanzmann thrombasthenia associated with macrothrombocytopenia.

J Thromb Haemost 2019 Mar 13. Epub 2019 Mar 13.

Reference Center for Platelet Disorders, Pessac.

Background: Acquired Glanzmann thrombasthenia (GT) is a bleeding disorder generally caused by anti-α β autoantibodies.

Objectives: We aimed to characterize the molecular mechanism leading to a progressive GT-like phenotype in a patient with chronic immune thrombocytopenia.

Patient, Methods And Results: The patient suffered from repeated episodes of gastrointestinal bleedings and further studies indicated a moderate platelet aggregation defect. Read More

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http://dx.doi.org/10.1111/jth.14424DOI Listing
March 2019
1 Read

An exploratory comparison of single intra-articular injection of platelet-rich plasma vs hyaluronic acid in treatment of haemophilic arthropathy of the knee.

Haemophilia 2019 Mar 13. Epub 2019 Mar 13.

Haemophilia Care and Research Center, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Introduction: Intra-articular platelet-rich plasma (PRP) injection therapy has been extensively applied in clinical practice to treat musculoskeletal disorders such as osteoarthritis, but the treatment for haemophilic arthropathy is rarely reported.

Aims: This study aimed to compare the efficacy of intra-articular PRP vs hyaluronic acid (HA) injections in treating haemophilic arthropathy of knee joints.

Patients: Twenty-two haemophilia patients (mean age, 41. Read More

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http://dx.doi.org/10.1111/hae.13711DOI Listing
March 2019
1 Read

Endothelial to Mesenchymal Transition: Role in Physiology and in the Pathogenesis of Human Diseases.

Physiol Rev 2019 Apr;99(2):1281-1324

Jefferson Institute of Molecular Medicine, Thomas Jefferson University , Philadelphia, Pennsylvania.

Numerous studies have demonstrated that endothelial cells are capable of undergoing endothelial to mesenchymal transition (EndMT), a newly recognized type of cellular transdifferentiation. EndMT is a complex biological process in which endothelial cells adopt a mesenchymal phenotype displaying typical mesenchymal cell morphology and functions, including the acquisition of cellular motility and contractile properties. Endothelial cells undergoing EndMT lose the expression of endothelial cell-specific proteins such as CD31/platelet-endothelial cell adhesion molecule, von Willebrand factor, and vascular-endothelial cadherin and initiate the expression of mesenchymal cell-specific genes and the production of their encoded proteins including α-smooth muscle actin, extra domain A fibronectin, N-cadherin, vimentin, fibroblast specific protein-1, also known as S100A4 protein, and fibrillar type I and type III collagens. Read More

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http://dx.doi.org/10.1152/physrev.00021.2018DOI Listing
April 2019
1 Read

Inhibitory effects of scoparone from chestnut inner shell on platelet-derived growth factor-BB-induced vascular smooth muscle cell migration and vascular neointima hyperplasia.

J Sci Food Agric 2019 Mar 12. Epub 2019 Mar 12.

Department of Physiology, School of Medicine, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, Korea.

Background: The chestnut (Castanea crenata) inner shells have diverse effects such as anti-cancer, and anti-oxidant activities. We therefore explored the effects of extract from chestnut inner shells and its bioactive molecule scoparone on vascular smooth muscle cell migration and vessel damage.

Results: The ethanol extract of chestnut inner shells inhibited platelet-derived growth factor (PDGF)-BB-induced migration of rat aortic smooth muscle cells (RASMCs) and contained eleven major compounds. Read More

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http://dx.doi.org/10.1002/jsfa.9674DOI Listing

Simplifying the diagnosis of inherited platelet disorders? The new tools do not make it any easier.

Blood 2019 Mar 11. Epub 2019 Mar 11.

Institut fuer Immunologie und Transfusionsmedizin, Universitaetsmedizin Greifswald, Greifswald, Germany.

Molecular causes of many inherited platelet disorders have been unraveled. Next generation sequencing facilitates diagnosis in 30-50% of patients. However, interpretation of genetic variants is challenging and requires careful evaluation in the context of the patient's phenotype. Read More

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http://dx.doi.org/10.1182/blood-2019-01-852350DOI Listing

Attenuation of the effects of oxidative stress by the MAO-inhibiting antidepressant and carbonyl scavenger phenelzine.

Chem Biol Interact 2019 Mar 8. Epub 2019 Mar 8.

Department of Psychiatry (Neurochemical Research Unit), University of Alberta, Edmonton, Canada; Department of Medicine (Neurology), University of Alberta, Edmonton, Canada. Electronic address:

Phenelzine (β-phenylethylhydrazine) is a monoamine oxidase (MAO)-inhibiting antidepressant with anxiolytic properties. It possesses a number of important pharmacological properties which may alter the effects of oxidative stress. After conducting a comprehensive literature search, the authors of this review paper aim to provide an overview and discussion of the mechanisms by which phenelzine may attenuate oxidative stress. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.03.003DOI Listing
March 2019
1 Read

Liver rupture in a 28-year-old primigravida with superimposed pre-eclampsia and hemolysis, elevated liver enzyme levels, and low platelet count syndrome.

J Obstet Gynaecol Res 2019 Mar 10. Epub 2019 Mar 10.

Department of Obstetrics and Gynecology, LMU Munich, Munich, Germany.

Serious hepatic complications, although rare, are one of the leading causes of maternofetal morbidity and mortality in hypertensive pregnancy disorders. A 28-year-old primigravida was transferred to our hospital complaining of refractory epigastric pain in the 29th week of pregnancy and was subsequently admitted due to superimposed pre-eclampsia and hemolysis, elevated liver enzyme levels, and low platelet count syndrome. Following a pathological cardiotocogram, a cesarean section was performed. Read More

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http://dx.doi.org/10.1111/jog.13941DOI Listing
March 2019
2 Reads

Programmed Cell Death Receptor (PD-1) Ligand (PD-L1) expression in Philadelphia chromosome-negative myeloproliferative neoplasms.

Leuk Res 2019 Apr 28;79:52-59. Epub 2019 Feb 28.

Division of Hematology/Oncology, Brookdale University Hospital Medical Center, Brooklyn, NY 11212, USA.

Programmed Cell Death Receptor (PD-1) and its Ligand (PD-L1) pathway inhibitor therapy has been explored in the field of oncology treatment mainly for solid tumors. In hematologic malignancies, there is limited information except for Hodgkin's lymphoma, and there is even less information regarding myeloproliferative neoplasm (MPN). Therefore, we explored this by first measuring PD-1 and PD-L1 levels (percentage of positive cells) in 63 patients with Philadelphia chromosome-negative MPN (Ph(-) MPN), including 16 MF (12 PMF, 2 post-PV-MF, 2 post-ET-MF), 29 ET, and 18 PV. Read More

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http://dx.doi.org/10.1016/j.leukres.2019.02.010DOI Listing
April 2019
1 Read
2.351 Impact Factor

RASGRP2 gene variations associated with platelet dysfunction and bleeding.

Platelets 2019 Mar 8:1-5. Epub 2019 Mar 8.

a Servicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonación , Universidad de Murcia , Murcia , Spain.

This manuscript reviews pathogenic variants in RASGRP2, which are the cause of a relatively new autosomal recessive and nonsyndromic inherited platelet function disorder, referred to as platelet-type bleeding disorder-18 (BDPLT18)(OMIM:615888). To date, 18 unrelated BDPLT18 pedigrees have been reported, harboring 19 different homozygous or compound heterozygous RASGRP2 variants. Patients with this disease present with lifelong moderate to severe bleeding, with epistaxis as the most common and relevant bleeding symptom. Read More

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http://dx.doi.org/10.1080/09537104.2019.1585528DOI Listing

Long-term treatment with romiplostim and treatment-free platelet responses in children with chronic immune thrombocytopenia.

Haematologica 2019 Mar 7. Epub 2019 Mar 7.

Amgen Inc., Thousand Oaks, CA, USA.

Children with immune thrombocytopenia ≥6 months completing a romiplostim study received weekly subcutaneous romiplostim (1-10 mg/kg targeting platelet counts of 50-200x10/L) in this extension to examine romiplostim's long-term safety and efficacy. Sixty-five children received romiplostim for a median (range) of 2.6 (0. Read More

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http://dx.doi.org/10.3324/haematol.2018.202283DOI Listing
March 2019
1 Read

Modified lipoproteins in periodontitis - a link to cardiovascular disease?

Biosci Rep 2019 Mar 6. Epub 2019 Mar 6.

Department of Medical Sciences, Örebro University, Örebro, Sweden

There is a strong association between periodontal disease and atherosclerotic cardiovascular disorders. A key event in the development of atherosclerosis is accumulation of modified lipoproteins within the arterial wall. We hypothesize that patients with periodontitis have an altered lipoprotein profile towards an atherogenic form. Read More

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http://dx.doi.org/10.1042/BSR20181665DOI Listing
March 2019
1 Read

Platelet Glycoprotein IIb/IIIa Receptor Inhibitor Tirofiban in Acute Ischemic Stroke.

Drugs 2019 Mar 6. Epub 2019 Mar 6.

Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, No. 119 Nan Sihuan West Road, Fengtai District, Beijing, 100160, People's Republic of China.

Tirofiban is a non-peptide selective glycoprotein (GP) IIb/IIIa receptor inhibitor that reversibly inhibits fibrinogen-dependent platelet aggregation and subsequent formation of thrombi, which contribute to the major atherosclerotic complications in the development, progression, and resolution of ischemic stroke. The adjunctive use of tirofiban has been extensively evaluated in progressive stroke, combined intravenous thrombolysis (IVT), and endovascular treatment (EVT) in both preclinical and clinical studies. A body of evidence has been accumulated on the risks and benefits associated with tirofiban in terms of prevention of stroke progression, stent thrombosis, improvement in functional independence, and mortality, especially among high-risk ischemic stroke patients as a further strategy alongside conventional treatment. Read More

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http://link.springer.com/10.1007/s40265-019-01078-0
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http://dx.doi.org/10.1007/s40265-019-01078-0DOI Listing
March 2019
3 Reads

Platelets compensate for poor thrombin generation in type 3 von Willebrand disease.

Platelets 2019 Mar 5:1-9. Epub 2019 Mar 5.

b Faculty of Medicine , University of Helsinki , Helsinki , Finland.

In type 3 von Willebrand disease (VWD3), the most severe form with absent von Willebrand factor (VWF), the bleeding phenotype is variable. Platelet contribution to the hemostatic defect in VWD3 calls upon further studies. We investigated the contribution of platelets to in vitro thrombin generation (TG) and platelet procoagulant activity in VWD3. Read More

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http://dx.doi.org/10.1080/09537104.2019.1581922DOI Listing
March 2019
2 Reads

Crohn's-like acute severe colitis associated with Hermansky-Pudlak syndrome: A case report.

World J Gastroenterol 2019 Feb;25(8):1031-1036

Institut des Maladies de l'Appareil Digestif, Department of Gastroenterology and Digestive Oncology, Nantes University Hospital, Nantes Cedex 44093, France.

Background: Hermansky-Pudlak syndrome (HPS) is a rare autosomal recessive disorder characterized by oculocutaneous albinism, platelet storage pool deficiency and systemic complications associated with ceroid deposition in the reticuloendothelial system. HPS types 1 and 4 are associated with Crohn's disease (CD)-like gastrointestinal disorders, such as granulomatous enterocolitis or perianal disease. Cases of colitis can be particularly severe and, before the use of anti-tumor necrosis factor alpha (TNFα) therapy had become common, were reported as showing poor responsiveness to medical treatment. Read More

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http://dx.doi.org/10.3748/wjg.v25.i8.1031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397731PMC
February 2019
2 Reads

Summary and Review of the Abstracts on Hemostasis/Thrombosis Presented at Haematocon 2018, Kochi.

Authors:
Prashant Sharma

Indian J Hematol Blood Transfus 2019 Jan 24;35(1):32-36. Epub 2019 Jan 24.

Department of Hematology, Postgraduate Institute of Medical Education and Research, Level 5, Research Block A, Sector 12, Chandigarh, 160012 India.

The hemostatic pathways involve a complex interplay of a vast array of inherited and acquired factors. Derangements of these pathways lead to several disorders that are complex and challenging not just for laboratory and clinical hematologists but also of concern to public health officials and policy makers. The past decade has seen an increased focus on research in this area with several recent meetings focusing on the diagnosis and management of persons afflicted with these disorders. Read More

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http://link.springer.com/10.1007/s12288-019-01076-y
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http://dx.doi.org/10.1007/s12288-019-01076-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369065PMC
January 2019
5 Reads
0.234 Impact Factor

Serum carnitine levels of children with epilepsy: Related factors including valproate.

Brain Dev 2019 Feb 28. Epub 2019 Feb 28.

Department of Pediatrics, Aichi Medical University, Japan.

Objective: This study measured the serum carnitine levels in patients with epilepsy and determined the factors contributing to low carnitine levels.

Methods: We measured the serum carnitine levels in 94 consecutive patients with epilepsy, including the free carnitine (FC) and acylcarnitine fractions, using an enzyme cycling method. We defined a low FC as a serum FC level < 36 μmol/L. Read More

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http://dx.doi.org/10.1016/j.braindev.2019.02.010DOI Listing
February 2019

Congenital papillomavirus infection in cattle: Evidence for transplacental transmission.

Vet Microbiol 2019 Mar 25;230:95-100. Epub 2019 Jan 25.

Dipartimento di Biologia, Università di Napoli Federico II, Napoli, Italy.

Vertical transmission of bovine papillomavirus (BPV) infection was investigated on livers and kidneys of four foetuses from cows suffering from BPV-2-associated urothelial cancers of the urinary bladder. PCR analysis revealed the presence of BPV-2 E5 DNA in the livers and kidneys of two foetuses. Amplified DNA fragments, composed of 502 bp, showed a 100% homology with BPV-2 sequences (GenBank accession number: M20219. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03781135183134
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http://dx.doi.org/10.1016/j.vetmic.2019.01.019DOI Listing
March 2019
1 Read

CD36 signaling in vascular redox stress.

Free Radic Biol Med 2019 Feb 27. Epub 2019 Feb 27.

Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI, USA; Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA. Electronic address:

Scavenger receptor CD36 is a multifunctional membrane protein that promotes thrombosis in conditions of oxidative stress such as metabolic disorders including dyslipidemia, diabetes mellitus, and chronic inflammation. In these conditions, specific reactive oxidant species are generated that are context and cell dependent. In the vasculature, CD36 signaling in smooth muscle cells and endothelial cells promotes generation of reactive oxygen species, genetic downregulation of antioxidant genes, and impaired smooth muscle and endothelial function. Read More

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http://dx.doi.org/10.1016/j.freeradbiomed.2019.02.021DOI Listing
February 2019

Improving engraftment of hepatocyte transplantation using alpha-1 antitrypsin as an immune modulator.

J Mol Med (Berl) 2019 Feb 28. Epub 2019 Feb 28.

Paediatric Liver, GI and Nutrition Centre, King's College London School of Medicine at King's College Hospital, Denmark Hill, London, UK.

For patients with non-cirrhotic liver-based metabolic disorders, hepatocyte transplantation can be an effective treatment. However, long-term function of transplanted hepatocytes following infusion has not been achieved due to insufficient numbers of hepatocytes reaching the liver cell plates caused by activation of the instant blood-mediated inflammatory reaction (IBMIR). Our aim was to determine if the natural immune modulator, alpha-1 antitrypsin (AAT), could improve engraftment of transplanted hepatocytes and investigate its mechanism of action. Read More

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http://dx.doi.org/10.1007/s00109-019-01747-3DOI Listing
February 2019

Differences and similarities in ibrutinib and acalabrutinib effects on platelet functions.

Haematologica 2019 Feb 28. Epub 2019 Feb 28.

Inserm U1048 and UniversitéToulouse 3,Laboratoire Hématologie CHU de Toulouse,France;

While efficient to treat B-cell malignancies, Bruton's tyrosine kinase inhibitors are consistently reported to increase the bleeding risk. Analyzing platelet aggregation response to collagen in platelet-rich-plasma allowed us to identify two groups in the healthy population characterized by low or high sensitivity to ibrutinib in vitro. Inhibition of drug efflux pumps induced a shift from ibrutinib low to high sensitive platelets. Read More

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http://dx.doi.org/10.3324/haematol.2018.207183DOI Listing
February 2019
1 Read

Complications of whole-exome sequencing for causal gene discovery in primary platelet secretion defects.

Haematologica 2019 Feb 28. Epub 2019 Feb 28.

Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico and Università degli Studi di Milano

Primary platelet secretion defects are heterogeneous group of functional defects characterized by reduced platelet granule secretion upon stimulation by different agonists. The clinical and laboratory heterogeneity of primary platelet secretion defects warrants a tailored approach. We performed a pilot study in order to develop DNA sequence analysis pipelines for gene discovery and to create a list of candidate causal genes for platelet secretion defects. Read More

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http://dx.doi.org/10.3324/haematol.2018.204990DOI Listing
February 2019

Cross-sectional study of neutrophil-lymphocyte, platelet-lymphocyte and monocyte-lymphocyte ratios in mood disorders.

Gen Hosp Psychiatry 2019 Feb 15;58:7-12. Epub 2019 Feb 15.

Department of Medicine and Surgery, University of Milano Bicocca, Monza, MB, Italy.

Objective: Neutrophil-lymphocyte, monocyte-lymphocyte and platelet-lymphocyte ratio are inexpensive and reproducible biomarkers of inflammation found to be elevated in mood disorders. This study aimed to compare inflammatory ratios between bipolar disorder and major depressive disorder and between bipolar disorder manic episodes and bipolar disorder depressive episodes.

Method: We included 142 Caucasian patients (major depressive disorder: n = 36; bipolar disorder manic episode: n = 66; bipolar disorder depressive episode: n = 40). Read More

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http://dx.doi.org/10.1016/j.genhosppsych.2019.02.003DOI Listing
February 2019
1 Read

Treatment of Acute Kidney Injury in Hemolythic Uremic Syndrome (TTP).

Med Arch 2018 Dec;72(6):453-455

Clinic of Hemodialysis, Clinical Center University of Sarajevo, Bosnia and Herzegovina.

Introduction: Plasmapheresis is often used as a therapy in the treatment of thrombotic thrombocytopenic purpura (TTP). TTP is manifested in thrombotic microangiopathy, consumed thrombocytopenia, hemolytic anemia and acute kidney injury with HUS development, neurologic dysfunction, and fever.

Case Report: we will present a case of a patient with acute kidney injury and refractory TTP at the beginning of hospitalization, subsequently manifested in secondary nephrotic syndrome. Read More

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https://www.ejmanager.com/fulltextpdf.php?mno=302643874
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http://dx.doi.org/10.5455/medarh.2018.72.453-455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340615PMC
December 2018
6 Reads

Role of Platelet Transfusion in the Reversal of Anti-Platelet Therapy.

Transfus Med Rev 2019 Jan 25. Epub 2019 Jan 25.

Division of Hematology/Oncology, UT Southwestern Medical Center, Dallas, TX; Division of Transfusion Medicine and Hemostasis, UT Southwestern Medical Center, Dallas, TX. Electronic address:

Antiplatelet therapy is extensively used in the primary and secondary prophylaxis of arterial thrombotic disorders. Aspirin, the most commonly used antiplatelet agent, is a cyclooxygenase-1 inhibitor and considered a mild to moderate inhibitor of platelet function. Therefore, often a second antiplatelet agent is necessary in certain clinical conditions requiring greater inhibition of platelet function. Read More

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http://dx.doi.org/10.1016/j.tmrv.2019.01.002DOI Listing
January 2019
2 Reads

Effects of three-month streptozotocin-induced diabetes in mice on blood platelet reactivity, COX-1 expression and adhesion potential.

Int J Exp Pathol 2019 Feb 27. Epub 2019 Feb 27.

Department of Haemostatic Disorders, Chair of Biomedical Sciences, Faculty of Health Sciences, Medical University of Lodz, Lodz, Poland.

Diabetes is associated with an increased risk of cardiovascular disease. This is partially attributed to an altered activation status of blood platelets in this disease. Previously, alterations have been shown in COX-1 and protease activated receptor (PAR)-3 receptor expression in platelets in two animal models of diabetes, there have not been studies which address expression of these proteins in mice with long-term streptozotocin (STZ)-induced diabetes. Read More

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http://dx.doi.org/10.1111/iep.12298DOI Listing
February 2019
1 Read

iTRAQ-based proteomic analysis of human umbilical vein endothelial cells with platelet endothelial aggregation receptor-1 knockdown.

J Cell Biochem 2019 Feb 27. Epub 2019 Feb 27.

Key Laboratory of Shenzhen Respiratory Diseases, Department of Pulmonary and Critical Care Medicine, Shenzhen Institute of Respiratory Disease, The First Affiliated Hospital of Southern University of Science and Technology, The Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, Shenzhen, Guangdong, China.

The disorders of hemostasis and coagulation were believed to be the main contributors to the pathogenesis of pulmonary thromboembolism (PTE), and platelets are the basic factors regulating hemostasis and coagulation and play important roles in the process of thrombosis. This study investigated the proteome of human umbilical vein endothelial cells (HUVECs) with platelet endothelial aggregation receptor-1 (PEAR1) knockdown using the isobaric tags for relative and absolute quantitation (iTRAQ) method and analyzed the role of differential abundance proteins (DAPs) in the regulation of platelets aggregation. Our results showed that the conditioned media-culturing HUVECs with PEAR1 knockdown partially suppressed the adenosine diphosphate (ADP)-induced platelet aggregation. Read More

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http://dx.doi.org/10.1002/jcb.28494DOI Listing
February 2019
3 Reads

Wnt-GSK3/-Catenin Regulates the Differentiation of Dental Pulp Stem Cells into Bladder Smooth Muscle Cells.

Stem Cells Int 2019 28;2019:8907570. Epub 2019 Jan 28.

State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Stomatology, Department of Operative Dentistry & Endodontics, School of Stomatology, Fourth Military Medical University, No. 145 Western Changle Road, Xi'an, Shaanxi 710032, China.

Smooth muscle cell- (SMC-) based tissue engineering provides a promising therapeutic strategy for SMC-related disorders. It has been demonstrated that human dental pulp stem cells (DPSCs) possess the potential to differentiate into mature bladder SMCs by induction with condition medium (CM) from bladder SMC culture, in combination with the transforming growth factor-1 (TGF-1). However, the molecular mechanism of SMC differentiation from DPSCs has not been fully uncovered. Read More

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http://dx.doi.org/10.1155/2019/8907570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369468PMC
January 2019
3 Reads

Microscopy-Based Automated Live Cell Screening for Small Molecules That Affect Ciliation.

Front Genet 2019 12;10:75. Epub 2019 Feb 12.

Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA, United States.

The primary monocilium, or cilium, is a single antenna-like organelle that protrudes from the surface of most mammalian cell types, and serves as a signaling hub. Mutations of cilia-associated genes result in severe genetic disorders termed ciliopathies. Among these, the most common is autosomal dominant polycystic kidney disease (ADPKD); less common genetic diseases include Bardet-Biedl syndrome, Joubert syndrome, nephronophthisis, and others. Read More

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http://dx.doi.org/10.3389/fgene.2019.00075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379280PMC
February 2019
1 Read

ACOG Practice Bulletin No. 207: Thrombocytopenia in Pregnancy.

Authors:

Obstet Gynecol 2019 Mar;133(3):e181-e193

Obstetricians frequently diagnose thrombocytopenia in pregnant women because platelet counts are included with automated complete blood cell counts obtained during routine prenatal screening (). Although most U.S. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003100DOI Listing
March 2019
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ACOG Practice Bulletin No. 207 Summary: Thrombocytopenia in Pregnancy.

Authors:

Obstet Gynecol 2019 Mar;133(3):589-591

Obstetricians frequently diagnose thrombocytopenia in pregnant women because platelet counts are included with automated complete blood cell counts obtained during routine prenatal screening (1). Although most U.S. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003101DOI Listing

Platelet and Red Blood Cell Counts, as well as the Concentrations of Uric Acid, but Not Homocysteinaemia or Oxidative Stress, Contribute Mostly to Platelet Reactivity in Older Adults.

Oxid Med Cell Longev 2019 16;2019:9467562. Epub 2019 Jan 16.

Chair of Biomedical Sciences, Department of Haemostatic Disorders, Faculty of Health Sciences, Medical University of Lodz, ul. Mazowiecka 6/8, 92-215 Lodz, Poland.

Purpose: The goal of this study was to estimate the hierarchical contribution of the most commonly recognized cardiovascular risk factors associated with atherogenesis to activation and reactivity of blood platelets in a group of men and women at ages 60-65.

Methods: Socioeconomic and anthropometric data were taken from questionnaires. Blood morphology and biochemistry were measured with standard diagnostic methods. Read More

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https://www.hindawi.com/journals/omcl/2019/9467562/
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http://dx.doi.org/10.1155/2019/9467562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360040PMC
March 2019
4 Reads

Thrombocytopenia and Predisposition to Acute Myeloid Leukemia due to Mosaic Ring 21 with Loss of : Cytogenetic and Molecular Characterization.

Mol Syndromol 2019 Jan 9;9(6):306-311. Epub 2018 Nov 9.

Department of Pathology, IL, USA.

Familial platelet disorder with predisposition to acute myeloid leukemia (FPD/AML) has been well documented in the literature and is a new entity within the latest revised edition of the WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues (OMIM). The disorder arises due to mutations within the gene in chromosome 21; mutations within the Runt-binding domain are the most commonly encountered anomalies that cause decreased platelet count and function. Rare cases of haploinsufficiency have also been shown to cause this disorder. Read More

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http://dx.doi.org/10.1159/000494645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381886PMC
January 2019
1 Read

Lesion Dynamics Under Varying Paracrine PDGF Signaling in Brain Tissue.

Bull Math Biol 2019 Feb 22. Epub 2019 Feb 22.

Precision Neurotherapeutics Innovation Program, Mayo Clinic, 5777 E Mayo Blvd, Phoenix, AZ, 85054, USA.

Paracrine PDGF signaling is involved in many processes in the body, both normal and pathological, including embryonic development, angiogenesis, and wound healing as well as liver fibrosis, atherosclerosis, and cancers. We explored this seemingly dual (normal and pathological) role of PDGF mathematically by modeling the release of PDGF in brain tissue and then varying the dynamics of this release. Resulting simulations show that by varying the dynamics of a PDGF source, our model predicts three possible outcomes for PDGF-driven cellular recruitment and lesion growth: (1) localized, short duration of growth, (2) localized, chronic growth, and (3) widespread chronic growth. Read More

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http://dx.doi.org/10.1007/s11538-019-00587-zDOI Listing
February 2019
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Platelets retain inducible alpha granule secretion by P-selectin expression but exhibit mechanical dysfunction during trauma-induced coagulopathy.

J Thromb Haemost 2019 Feb 19. Epub 2019 Feb 19.

Department of Emergency Medicine, University of Washington, Seattle, WA, USA.

Essentials Platelets in trauma-induced coagulopathy (TIC) are impaired, but the mechanism is not known. We performed comprehensive longitudinal platelet function testing in trauma patient samples. Platelets in TIC are widely impaired early after injury, but platelet activatability is intact. Read More

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http://dx.doi.org/10.1111/jth.14414DOI Listing
February 2019
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Inherited Bleeding Disorders in Iraq and Consanguineous Marriage.

Int J Hematol Oncol Stem Cell Res 2018 Oct;12(4):273-281

The National Center of Hematology, Al-Mustansiriyah University, Baghdad, Iraq.

Consanguineous marriage is defined as inbreeding between second cousins or closer. In such families there will be a potential increase in the autosomal recessive traits with its lethal effect, with an increased risk of morbidity and mortality in the new generation. Inherited bleeding disorders (InBDs) are rare complicated diseases, difficult and expensive to treat, the defect usually due to quantitative or qualitative deficiency of clotting factors, platelets or fibrinolysis. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375379PMC
October 2018
1 Read

High-dose intravenous immunoglobulin to treat spontaneous heparin-induced thrombocytopenia syndrome.

J Thromb Haemost 2019 Feb 18. Epub 2019 Feb 18.

Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.

Essentials Spontaneous HIT syndrome clinically/serologically resembles HIT but without proximate heparin. Rarely, spontaneous HIT syndrome complicates total knee arthroplasty surgery. Mesenteric vein thrombosis is a rare presentation of spontaneous HIT syndrome. Read More

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http://dx.doi.org/10.1111/jth.14411DOI Listing
February 2019
4 Reads

The Effect of Platelet-Rich Plasma on the Temporomandibular Joint After Radiotherapy in Rabbits.

Ann Otol Rhinol Laryngol 2019 Feb 15:3489419830121. Epub 2019 Feb 15.

1 Department of Otorhinolaryngology, University of Health Sciences Ankara Dr Abdurrahman Yurtaslan Oncology Training and Research Hospital, Ankara, Turkey.

Objectives:: Platelet-rich plasma (PRP) was administered into the temporomandibular joint (TMJ) space, which had been exposed to radiotherapy (RT), in an attempt to prevent and/or treat the late-term complications associated with RT when used for the treatment of head and neck cancers (nasopharyngeal cancer in particular) on the musculoskeletal system.

Methods:: A total of 13 adult male New Zealand ( Oryctolagus cuniculus) rabbits were used in the study. The animals were classified into 3 groups: 6 in the RT group, 6 in the RT+PRP group, and 1 in the control group (exposed to neither). Read More

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http://journals.sagepub.com/doi/10.1177/0003489419830121
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http://dx.doi.org/10.1177/0003489419830121DOI Listing
February 2019
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A review of pig liver xenotransplantation: Current problems and recent progress.

Xenotransplantation 2019 Feb 15:e12497. Epub 2019 Feb 15.

Department of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, China.

Pig liver xenotransplantation appears to be more perplexing when compared to heart or kidney xenotransplantation, even though great progress has been achieved. The relevant molecular mechanisms involved in xenogeneic rejection, including coagulopathy, and particularly thrombocytopenia, are complex, and need to be systematically investigated. The deletion of expression of Gal antigens in the liver graft highlights the injurious impact of nonGal antigens, which continue to induce humoral rejection. Read More

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http://dx.doi.org/10.1111/xen.12497DOI Listing
February 2019
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Association of recurrent venous thromboembolism and circulating microRNAs.

Clin Epigenetics 2019 Feb 13;11(1):28. Epub 2019 Feb 13.

Center for Primary Health Care Research, Wallenberglaboratoriet, Lund University/Region Skåne, Inga-Marie Nilssons gata 53, plan 6, Box 50332, 202 13, Malmö, Sweden.

Background: Patients with unprovoked first venous thromboembolism (VTE) are at a high risk of recurrence. Although circulating microRNAs (miRNAs) have been found to be associated with VTE and are markers of hypercoagulability, this study is the first to examine whether circulating miRNAs are associated with the risk of VTE recurrence.

Results: A nested case-control study design was used where plasma samples were obtained from 78 patients with unprovoked VTE from the Malmö Thrombophilia Study (MATS). Read More

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http://dx.doi.org/10.1186/s13148-019-0627-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374897PMC
February 2019
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Circulating Endothelial Cells, Circulating Endothelial Progenitor Cells, and Circulating Microparticles in Type 1 Diabetes Mellitus.

Clin Appl Thromb Hemost 2019 Jan-Dec;25:1076029618825311

2 Pediatric Department, Faculty of Medicine, Assiut University, Assiut, Egypt.

Background And Aim:: Hyperglycemia in type 1 diabetes (T1D) is accompanied by endothelial cell dysfunction which is known to contribute to the pathogenesis of cardiovascular disorders. The aim of the current study was to explore the profile of circulating endothelial progenitor cells (EPCs), circulating endothelial cells (CECs), endothelial and platelet derived micropaticles (EMPs, PMPs) and total microparticles (TMPs), in T1D children in relation to each other and to the metabolic disorders accompanying T1D.

Patients And Methods:: Thirty T1D patients and 20 age and sex matched healthy volunteers were assessed for HbA1c level and lipid profile. Read More

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http://dx.doi.org/10.1177/1076029618825311DOI Listing
February 2019
7 Reads

Plasma thrombopoietin levels as additional tool in clinical management of thrombocytopenic neonates.

Platelets 2019 Feb 13:1-6. Epub 2019 Feb 13.

a Department of Immunohematology Diagnostic Services Amsterdam , Sanquin Diagnostic Services , Amsterdam , The Netherlands.

Plasma thrombopoietin (Tpo) levels distinguish thrombocytopenia resulting from increased platelet destruction or decreased platelet production. We investigated whether measuring plasma Tpo levels in thrombocytopenic newborns is of diagnostic value to establish the underlying mechanism of thrombocytopenia. Tpo levels were measured with in-house developed ELISA in samples referred to our center because of thrombocytopenia noticed in the first 10 days of life. Read More

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https://www.tandfonline.com/doi/full/10.1080/09537104.2019.1
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http://dx.doi.org/10.1080/09537104.2019.1572877DOI Listing
February 2019
3 Reads

Establishment and maintenance of blood-lymph separation.

Cell Mol Life Sci 2019 Feb 13. Epub 2019 Feb 13.

Division of Cardiovascular Medicine, University of Massachusetts Medical School, The Albert Sherman Center, AS7-1047, 368 Plantation St, Worcester, MA, 01605, USA.

Hippocratic Corpus, a collection of Greek medical literature, described the functional anatomy of the lymphatic system in the fifth century B.C. Subsequent studies in cadavers and surgical patients firmly established that lymphatic vessels drain extravasated interstitial fluid, also known as lymph, into the venous system at the bilateral lymphovenous junctions. Read More

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http://dx.doi.org/10.1007/s00018-019-03042-3DOI Listing
February 2019
1 Read