75,103 results match your criteria Platelet Disorders


[Effectiveness of treatment with platelet-rich plasma (PRP) injections in degenerative joint and tendon disorders].

Ned Tijdschr Geneeskd 2020 Aug 6;164. Epub 2020 Aug 6.

Erasmus MC, Rotterdam, afd. Huisartsgeneeskunde.

Osteoarthritis and tendon disorders of the lower extremities are common problems for which it can be challenging to find effective treatments. Injection of platelet-rich plasma (PRP) is a treatment that locally affects inflammation and repair of tissues. In the last decade, many clinical studies have been conducted into treatment with PRP injections, with varying results. Read More

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Volatomic analysis identifies compounds that can stratify non-alcoholic fatty liver disease.

JHEP Rep 2020 Oct 15;2(5):100137. Epub 2020 Jun 15.

Hepatology Laboratory and Centre for Liver and Digestive Disorders, Royal Infirmary of Edinburgh and The University of Edinburgh, Edinburgh, UK.

Background & Aims: Analysis of volatile organic compounds (VOCs) in exhaled breath, 'volatomics', provides opportunities for non-invasive biomarker discovery and novel mechanistic insights into a variety of diseases. The purpose of this pilot study was to compare breath VOCs in an initial cohort of patients with non-alcoholic fatty liver disease (NAFLD) and healthy controls.

Methods: Breath samples were collected from 15 participants with Child-Pugh class A NAFLD cirrhosis, 14 with non-cirrhotic NAFLD, and 14 healthy volunteers. Read More

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http://dx.doi.org/10.1016/j.jhepr.2020.100137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397704PMC
October 2020

Tale of fat and fib - cardiac lipoma managed with radiofrequency ablation: A case report.

World J Cardiol 2020 Jun;12(6):285-290

Department of Cardiology, Saint Vincent Hospital, Worcester, MA 01604, United States.

Background: Cardiac lipoma and lipomatous hypertrophy of interatrial septum (LHIS) are very rare disorders with distinct pathological features. While cardiac lipoma is a well-circumscribed encapsulated tumor of mature adipocytes, LHIS is due to entrapment of fat cells in the interatrial septum during embryogenesis. Although a biopsy is the definitive diagnostic test, these disorders can be differentiated by a cardiac magnetic resonance imaging (MRI). Read More

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http://dx.doi.org/10.4330/wjc.v12.i6.285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383356PMC

A Case of Acquired von Willebrand Disease Secondary to Myeloproliferative Neoplasm.

Case Rep Oncol 2020 May-Aug;13(2):733-737. Epub 2020 Jun 26.

Department of Hematology, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar.

Acquired von Willebrand Disease (AVWD) is a rare disorder in which qualitative or quantitative defects in von Willebrand factor (VWF) occur secondary to other conditions. AVWD occurs in patients with myeloproliferative disorders due to formation of autoantibodies against VWF and development of excessive shear stress causing disruption of VWF multimers. AVWD is different from congenital VWD in its acute onset and absence of family history. Read More

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http://dx.doi.org/10.1159/000507883DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383181PMC

Differential approach to peripheral blood cell ratios in patients with systemic lupus erythematosus and various manifestations.

Rheumatol Int 2020 Aug 9. Epub 2020 Aug 9.

Department of Rheumatology and Connective Tissue Diseases, The Medical University of Lublin, Ul. Jaczewskiego 8, 20-954, Lublin, Poland.

New markers of systemic lupus erythematosus (SLE) activity are under investigation. In recent years, the researchers have been focusing increased attention on the role of haematological indicators in assessing the disease activity. Specifically, neutrophil-, basophil-, eosinophil-, monocyte- and platelet-to-lymphocyte ratios (NLR, BLR, ELR, MLR and PLR) have been considered. Read More

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http://dx.doi.org/10.1007/s00296-020-04669-3DOI Listing

ASK1 Regulates Immune-Mediated Thrombocytopenia, Thrombosis, and Systemic Shock.

J Thromb Haemost 2020 Aug 7. Epub 2020 Aug 7.

Cardeza Center for Hemostasis, Thrombosis, and Vascular Biology, Cardeza Foundation for Hematologic Research, Department of Medicine, Thomas Jefferson University, Philadelphia, PA, USA.

Background: Immune complexes (ICs) bind to and activate platelets via FcγRIIA causing patients to experience thrombocytopenia, as well as an increased risk of forming occlusive thrombi. While platelets have been shown to mediate IC-induced pathologies, the mechanisms involved have yet to be fully elucidated. We identified that Apoptosis Signal-Regulating Kinase 1 (ASK1) is present in both human and mouse platelets and potentiates many platelet functions. Read More

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http://dx.doi.org/10.1111/jth.15049DOI Listing

Incipient Diabetes Mellitus and Nascent Thyroid Disease Presenting as Beard Alopecia Areata: Case Report and Treatment Review of Alopecia Areata of the Beard.

Cureus 2020 Jul 31;12(7):e9500. Epub 2020 Jul 31.

Dermatology, San Diego Family Dermatology, National City, USA.

Alopecia areata is a non-scarring hair loss that commonly presents on the scalp. In men, when this condition results in facial hair loss on the cheek, jaw, and neck, it is referred to as beard alopecia areata. Beard alopecia areata can be associated with autoimmune conditions, such as diabetes mellitus, thyroid disorders, and vitiligo. Read More

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http://dx.doi.org/10.7759/cureus.9500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398044PMC

Complement C1q Enhances Primary Hemostasis.

Front Immunol 2020 16;11:1522. Epub 2020 Jul 16.

Laboratory of Clinical Immunology, Department of Biomedicine, University of Basel, Basel, Switzerland.

The cross-talk between the inflammatory complement system and hemostasis is becoming increasingly recognized. The interaction between complement C1q, initiation molecule of the classical pathway, and von Willebrand factor (vWF), initiator molecule of primary hemostasis, has been shown to induce platelet rolling and adhesion . As vWF disorders result in prolonged bleeding, a lack of C1q as binding partner for vWF might also lead to an impaired hemostasis. Read More

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http://dx.doi.org/10.3389/fimmu.2020.01522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381122PMC

Cell therapy in female infertility-related diseases: Emphasis on recurrent miscarriage and repeated implantation failure.

Life Sci 2020 Aug 4:118181. Epub 2020 Aug 4.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

About 17% of couples suffer from infertility conditions, worldwide. The most common reasons for female infertility are ovulation disorders, fallopian-related disorders, RM, RIF, endometriosis, and unexplained infertility. Despite advances in Assisted Reproductive Technologies, infertility has remained a serious problem. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.118181DOI Listing

Platelet count and disease - editorial policy.

Platelets 2020 Aug 7:1-2. Epub 2020 Aug 7.

Institute for Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham , Birmingham, UK.

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http://dx.doi.org/10.1080/09537104.2020.1802002DOI Listing

Thrombin generation abnormalities in Quebec platelet disorder.

Int J Lab Hematol 2020 Aug 6:e13302. Epub 2020 Aug 6.

Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.

Introduction: Calibrated automated thrombograms (CAT) with platelet-poor (PPP) and platelet-rich plasma (PRP) have provided useful insights on bleeding disorders. We used CAT to assess thrombin generation (TG) in Quebec platelet disorder (QPD)-a bleeding disorder caused by a PLAU duplication mutation that increases platelet (but not plasma) urokinase plasminogen activator (uPA), leading to intraplatelet (but not systemic) plasmin generation that degrades α-granule proteins and causes platelet (but not plasma) factor V (FV) deficiency.

Methods: Calibrated automated thrombograms was used to test QPD (n = 7) and control (n = 22) PPP and PRP, with or without added tranexamic acid (TXA). Read More

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http://dx.doi.org/10.1111/ijlh.13302DOI Listing

Postpartum Hypertension.

Curr Hypertens Rep 2020 Aug 6;22(8):58. Epub 2020 Aug 6.

Department of Cardiology, Helena Venizelou Hospital, Athens, Greece.

Purpose Of Review: Hypertension affects approximately 10% of pregnancies and may persist in the postpartum period. Furthermore, de novo hypertension may present after delivery, but its exact prevalence is not verified. Both types of hypertension expose the mother to eventually severe complications like eclampsia, stroke, pulmonary edema, and HELLP (hemolysis, elevated liver enzymes, low platelet) syndrome. Read More

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http://dx.doi.org/10.1007/s11906-020-01058-wDOI Listing

Platelet δ-Storage Pool Disease: An Update.

J Clin Med 2020 Aug 4;9(8). Epub 2020 Aug 4.

INSERM, EFS Grand Est, BPPS UMR-S 1255, FMTS, Université de Strasbourg, F-67000 Strasbourg, France.

Platelet dense-granules are small organelles specific to the platelet lineage that contain small molecules (calcium, adenyl nucleotides, serotonin) and are essential for the activation of blood platelets prior to their aggregation in the event of a vascular injury. Delta-storage pool diseases (δ-SPDs) are platelet pathologies leading to hemorrhagic syndromes of variable severity and related to a qualitative (content) or quantitative (numerical) deficiency in dense-granules. These pathologies appear in a syndromic or non-syndromic form. Read More

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http://dx.doi.org/10.3390/jcm9082508DOI Listing

Stress Enhances Proinflammatory Platelet Activity: the Impact of Acute and Chronic Mental Stress.

J Neuroimmune Pharmacol 2020 Aug 5. Epub 2020 Aug 5.

Department of Psychiatry, Psychotherapy and Psychosomatics, Division of Psychiatry II, Medical University Innsbruck, Innsbruck, Austria.

The role of platelets in hemostasis and thrombosis has long been recognized, recently their contribution to immunological and inflammatory processes is emerging. Platelets could be the missing link between cardiovascular disease, chronic stress and depressive symptoms. Both physical and mental stressors cause platelet activation reflected by changes in platelet bioactivity and aggregation. Read More

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http://dx.doi.org/10.1007/s11481-020-09945-4DOI Listing

Clinical course and short-term outcome of postsplenectomy reactive thrombocytosis in children without myeloproliferative disorders: A single institutional experience from a developing country.

PLoS One 2020 5;15(8):e0237016. Epub 2020 Aug 5.

College of Medicine, QU Health, Qatar University, Doha, Qatar.

Objectives: To evaluate the clinical outcome and complications in the pediatric population who had splenectomy at our institution, emphasizing the incidence of postplenectomy reactive thrombocytosis (RT) and its clinical significance in children without underlying hematological malignancies.

Materials And Methods: The medical records of pediatric patients undergoing splenectomy were retrospectively reviewed for the period 1999-2018. The following variables were analyzed: Demographic parameters (age, sex), indications for surgery, operative procedures, preoperative and postoperative platelet count (postplenectomy RT), the use of anticoagulant therapy, and postoperative complications. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0237016PLOS
August 2020
3.234 Impact Factor

D-dimer surge and coagulation disorders in COVID-19 related pneumonia patients with cardiac injury: A case series.

Medicine (Baltimore) 2020 Jul;99(31):e21513

Department of Hematology, The First Hospital of Jilin University, Jilin Provincial Hematology Research Institute, National Key Discipline.

Background: Cardiac injury and coagulation disorders have been two increasing concerns in the management of patients with severe coronavirus disease (COVID-19). Coagulation disorders in COVID-19 patients with cardiac injury have not been characterized.

Methods: We analyzed the data of five COVID-19 patients with cardiac injury who had D-dimer surge (defined as a rapid increase in the D-dimer level in 72 h, from <5-21 μg/mL) during hospitalization, which were extracted from a registered retrospective study (ChiCTR2000031301). Read More

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http://dx.doi.org/10.1097/MD.0000000000021513DOI Listing

Type B insulin resistance syndrome associated with connective tissue disease and psoriasis.

Endocrinol Diabetes Metab Case Rep 2020 Aug 4;2020. Epub 2020 Aug 4.

Department of Internal Medicine and Metabolic Diseases, Diabetology and Internal Medicine.

Summary: Type B insulin resistance syndrome (TBIR) is characterised by the rapid onset of severe insulin resistance due to circulating anti-insulin receptor antibodies (AIRAs). Widespread acanthosis nigricans is normally seen, and co-occurrence with other autoimmune diseases is common. We report a 27-year-old Caucasian man with psoriasis and connective tissue disease who presented with unexplained rapid weight loss, severe acanthosis nigricans, and hyperglycaemia punctuated by fasting hypoglycaemia. Read More

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http://dx.doi.org/10.1530/EDM-20-0027DOI Listing

Adenosine Receptor Agonists Increase the Inhibition of Platelet Function by P2Y Antagonists in a cAMP- and Calcium-Dependent Manner.

Pharmaceuticals (Basel) 2020 Jul 31;13(8). Epub 2020 Jul 31.

Department of Haemostasis and Haemostatic Disorders, Chair of Biomedical Sciences, Faculty of Health Sciences, Medical University of Lodz, Mazowiecka 6/8, 92-235 Lodz, Poland.

We have shown previously that platelet activity can be lowered through the simultaneous inhibition of P2Y receptor and activation of adenosine receptors (AR). This work explores this concept by testing the antiplatelet potential of nine AR agonists in combination with P2Y receptor antagonists-cangrelor and prasugrel metabolite. A panel of in vitro methods was used to assess platelet viability, P-selectin expression, GPIIb-IIIa activation, fibrinogen binding, calcium ion mobilization, VASP-P level, and cAMP formation, utilizing whole blood or isolated platelets from healthy volunteers. Read More

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http://dx.doi.org/10.3390/ph13080177DOI Listing

Commentary on "Therapeutic doses of recombinant factor VIIa in hemophilia generates thrombin in platelet-dependent and -independent mechanisms".

Authors:
Bjarne Østerud

J Thromb Haemost 2020 Aug;18(8):1853-1854

K.G. Jebsen Thrombosis Research and Expertise Center (TREC), UiT The Arctic University of Norway, Tromsø, Norway.

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http://dx.doi.org/10.1111/jth.14877DOI Listing

Structure-function of platelet glycoprotein Ib-IX.

J Thromb Haemost 2020 Jul 31. Epub 2020 Jul 31.

Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.

The glycoprotein (GP)Ib-IX receptor complex plays a critical role in platelet physiology and pathology. Its interaction with von Willebrand factor (VWF) on the subendothelial matrix instigates platelet arrest at the site of vascular injury, and is vital to primary hemostasis. Its reception to other ligands and counter-receptors in the blood stream also contribute to various processes of platelet biology that are still being discovered. Read More

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http://dx.doi.org/10.1111/jth.15035DOI Listing

Emerging evidence of a COVID-19 thrombotic syndrome has treatment implications.

Nat Rev Rheumatol 2020 Jul 30. Epub 2020 Jul 30.

Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.

Reports of widespread thromboses and disseminated intravascular coagulation (DIC) in patients with coronavirus disease 19 (COVID-19) have been rapidly increasing in number. Key features of this disorder include a lack of bleeding risk, only mildly low platelet counts, elevated plasma fibrinogen levels, and detection of both severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and complement components in regions of thrombotic microangiopathy (TMA). This disorder is not typical DIC. Read More

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http://dx.doi.org/10.1038/s41584-020-0474-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7391481PMC

CORR Synthesis: What Is the Role of Platelet-rich Plasma Injection in the Treatment of Tendon Disorders?

Clin Orthop Relat Res 2020 Aug;478(8):1817-1824

M. W. Labelle, R. E. Marcus, Department of Orthopaedic Surgery, Case Western Reserve University, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.

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http://dx.doi.org/10.1097/CORR.0000000000001312DOI Listing

Altered T-cell subset repertoire affects treatment outcome of patients with myelofibrosis.

Haematologica 2020 Jul 30. Epub 2020 Jul 30.

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;

Phenotypic characterization of T cells in myelofibrosis (MF) is intriguing owing to increased inflammation, markedly elevated pro-inflammatory cytokines, and altered distribution of T-cell subsets. Constitutive activation of Janus kinase-2 (JAK2) in the majority of MF patients contributes to the expression of the programmed cell death protein-1 (PD1) and T-cell exhaustion. We wondered whether T-cell activation affects treatment outcome of patients with MF and sought to determine whether the JAK1/2 inhibitor ruxolitinib affects the activation of T-cell subsets. Read More

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http://dx.doi.org/10.3324/haematol.2020.249441DOI Listing

Dynamics of Platelet Counts in Major Trauma: The Impact of Haemostatic Resuscitation and Effects of Platelet Transfusion-A Sub-Study of the Randomized Controlled RETIC Trial.

J Clin Med 2020 Jul 28;9(8). Epub 2020 Jul 28.

Department of Anesthesiology and Intensive Care Medicine, Medical University of Innsbruck, 6020 Innsbruck, Austria.

Although platelets play a central role in haemostasis, the dynamics of platelet counts during haemostatic resuscitation, the response to platelet transfusion, and effects on clinical outcome are poorly described for trauma patients. As a sub-study of the already published randomized controlled RETIC Study "Reversal of Trauma-induced Coagulopathy using First-line Coagulation Factor Concentrates or Fresh-Frozen Plasma" trial, we here analysed whether the type of first-line haemostatic resuscitation influences the frequency of platelet transfusion and determined the effects of platelet transfusion in coagulopathic patients with major trauma. Patients randomly received first-line plasma (FFP) or coagulation factor concentrates (CFC), mainly fibrinogen concentrate. Read More

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http://dx.doi.org/10.3390/jcm9082420DOI Listing

Peculiarities of Platelet Metabolism in Patients with Acute Coronary Syndrome with Anxiety-Depressive Disorders and Informativity of Enzymes in the Forecast of Development of Cardiovascular Complications.

Pharmaceuticals (Basel) 2020 Jul 28;13(8). Epub 2020 Jul 28.

Faculty of Medicine, Prof. V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Partizan Zheleznyak Street 1, 660022 Krasnoyarsk, Russia.

Anxiety-depressive disorders (ADD) are a risk factor of cardiovascular mortality in patients with coronary artery disease (CAD). Acute coronary syndrome (ACS) is the main clinical manifestation of a progressing CAD. Metabolic processes disorder in platelets can be one of the causes of cardiovascular complications in patients with ACS and concomitant ADD. Read More

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http://dx.doi.org/10.3390/ph13080169DOI Listing

The Roles of GRKs in Hemostasis and Thrombosis.

Int J Mol Sci 2020 Jul 28;21(15). Epub 2020 Jul 28.

Cardeza Foundation for Hematologic Research, Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA.

Along with cancer, cardiovascular and cerebrovascular diseases remain by far the most common causes of death. Heart attacks and strokes are diseases in which platelets play a role, through activation on ruptured plaques and subsequent thrombus formation. Most platelet agonists activate platelets via G protein-coupled receptors (GPCRs), which make these receptors ideal targets for many antiplatelet drugs. Read More

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http://dx.doi.org/10.3390/ijms21155345DOI Listing

[Inherited bleeding disorders in adolescents with excessive menstrual bleeding. Should we evaluate the fibrinolytic pathway?]

Rev Chil Pediatr 2020 Jun;91(3):385-390

Departamento de Pediatría, Pontificia Universidad Católica de Chile, Santiago, Chile.

Introduction: Heavy Menstrual Bleeding (EMB) is a frequent problem in adolescence. The prevalence of inherited bleeding disorders (IBD) as a cause of EMB is not well established and the involvement of fibri nolytic pathway defects has been poorly explored.

Objective: To determine the prevalence of IBD and fibrinolysis defects in adolescents with EMBs. Read More

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http://dx.doi.org/10.32641/rchped.v91i3.1571DOI Listing

Factors associated with the presence of headache in hospitalized COVID-19 patients and impact on prognosis: a retrospective cohort study.

J Headache Pain 2020 Jul 29;21(1):94. Epub 2020 Jul 29.

Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid, Spain.

Introduction: Headache is one of the most frequent neurologic manifestations in COVID-19. We aimed to analyze which symptoms and laboratory abnormalities were associated with the presence of headache and to evaluate if patients with headache had a higher adjusted in-hospital risk of mortality.

Methods: Retrospective cohort study. Read More

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http://dx.doi.org/10.1186/s10194-020-01165-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7388434PMC

Cellular and Molecular Aspects of Blood Cell-Endothelium Interactions in Vascular Disorders.

Int J Mol Sci 2020 Jul 27;21(15). Epub 2020 Jul 27.

Faculté de Médecine, Université Denis Diderot Paris, 75013 Paris, France.

In physiology and pathophysiology the molecules involved in blood cell-blood cell and blood cell-endothelium interactions have been identified. Platelet aggregation and adhesion to the walls belonging to vessels involve glycoproteins (GP), GP llb and GP llla and the GP Ib-IX-V complex. Red blood cells (RBCs) in normal situations have little interaction with the endothelium. Read More

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http://dx.doi.org/10.3390/ijms21155315DOI Listing

Role of Platelet Cytoskeleton in Platelet Biomechanics: Current and Emerging Methodologies and Their Potential Relevance for the Investigation of Inherited Platelet Disorders.

Hamostaseologie 2020 Aug 29;40(3):337-347. Epub 2020 Jul 29.

Department of Transfusion Medicine, Institute of Immunology and Transfusion Medicine, University Medicine Greifswald, Greifswald, Germany.

Cytoskeleton is composed of more than 100 proteins and represents a dynamic network of the cellular cytoplasm. Cytoskeletal functions include spatial organization of cellular components, structural connection of the cell with external environment, and biomechanical force generation. Cytoskeleton takes part, at different levels, in all phases of platelet biogenesis: megakaryocyte (MK) differentiation, MK maturation, and platelet formation. Read More

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http://dx.doi.org/10.1055/a-1175-6783DOI Listing

Subacute administration of Astaxanthin inhibits vitamin K-dependent clotting factors in rats.

J Food Biochem 2020 Jul 28:e13407. Epub 2020 Jul 28.

Department of Medical Physiology, College of Medicine, King Khalid University, Abha, Kingdom of Saudi Arabia.

This study investigated the effect of Astaxanthin (ASTX) on levels and activities of the clotting factors in control rats. Untreated or ASTX-treated rats (10 mg/kg, dissolved in DMSO) were used in this study. ASTX treatment was conducted for 10 days daily. Read More

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http://dx.doi.org/10.1111/jfbc.13407DOI Listing

Thrombotic microangiopathy due to Bothrops erythromelas: a case report in Northeast Brazil.

Rev Inst Med Trop Sao Paulo 2020 24;62:e53. Epub 2020 Jul 24.

Departamento de Medicina Interna, Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, Ceará, Brazil.

Bothrops erythromelas are serpents that belong to the Viperidae family, which are the main species responsible for human snakebites in Ceara State, Northeast Brazil. Thrombotic microangiopathy (TMA) is an uncommon group of disorders characterized by microangiopathic hemolytic anemia (MAHA), thrombocytopenia and acute kidney injury (AKI), and occurrence after snakebites have been rarely reported. In this report, we described the case of a 57 year-old-man without comorbidities who was bitten by a Bothrops erythromelas on his right ankle. Read More

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http://dx.doi.org/10.1590/s1678-9946202062053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7384591PMC

Heparin-Induced Thrombocytopenia in COVID-19.

J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620944091

John H. Stroger Hospital of Cook County, Chicago, IL, USA.

COVID-19 (coronavirus disease-2019) infection is a highly prothrombotic state, resulting from a dysregulation of the coagulation cascade. Therefore, thromboprophylaxis is strongly recommended in these patients, with some experts even advocating for therapeutic dosing to prevent thromboembolic events. Heparin-induced thrombocytopenia (HIT) is a well-known complication of heparin therapy. Read More

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http://dx.doi.org/10.1177/2324709620944091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7388103PMC

A family with an MYH9-related disorder with different phenotypes masquerading as immune thrombocytopaenia: an underreported disorder in Taiwan.

Int J Hematol 2020 Jul 25. Epub 2020 Jul 25.

Department of Internal Medicine, Changhua Christian Hospital, Changhua City, Taiwan.

A 66-year-old woman had experienced abnormal bleeding since the age of 7. Thrombocytopenia was not detected until she was 48, and immune thrombocytopenia was diagnosed at age 66. She also reported experiencing hearing disturbance since the age of 30 and acute renal failure since the age of 61 but reported no visual disturbance. Read More

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http://dx.doi.org/10.1007/s12185-020-02947-1DOI Listing

Covid-19: The Rollercoaster of Fibrin(Ogen), D-Dimer, Von Willebrand Factor, P-Selectin and Their Interactions with Endothelial Cells, Platelets and Erythrocytes.

Int J Mol Sci 2020 Jul 21;21(14). Epub 2020 Jul 21.

Department of Physiological Sciences, Faculty of Science, Stellenbosch University, Stellenbosch 7602, South Africa.

Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), also known as coronavirus disease 2019 (COVID-19)-induced infection, is strongly associated with various coagulopathies that may result in either bleeding and thrombocytopenia or hypercoagulation and thrombosis. Thrombotic and bleeding or thrombotic pathologies are significant accompaniments to acute respiratory syndrome and lung complications in COVID-19. Thrombotic events and bleeding often occur in subjects with weak constitutions, multiple risk factors and comorbidities. Read More

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http://dx.doi.org/10.3390/ijms21145168DOI Listing

Lysyl Oxidase (LOX): Functional Contributions to Signaling Pathways.

Biomolecules 2020 Jul 22;10(8). Epub 2020 Jul 22.

Department of Quantitative Health Sciences, John A. Burns School of Medicine, University of Hawaii, 651 Ilalo Street, Honolulu, HI 96813, USA.

Cu-dependent lysyl oxidase (LOX) plays a catalytic activity-related, primary role in the assembly of the extracellular matrix (ECM), a dynamic structural and regulatory framework which is essential for cell fate, differentiation and communication during development, tissue maintenance and repair. LOX, additionally, plays both activity-dependent and independent extracellular, intracellular and nuclear roles that fulfill significant functions in normal tissues, and contribute to vascular, cardiac, pulmonary, dermal, placenta, diaphragm, kidney and pelvic floor disorders. LOX activities have also been recognized in glioblastoma, diabetic neovascularization, osteogenic differentiation, bone matrix formation, ligament remodeling, polycystic ovary syndrome, fetal membrane rupture and tumor progression and metastasis. Read More

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http://dx.doi.org/10.3390/biom10081093DOI Listing

Comparison of mitochondrial transplantation by using a stamp-type multineedle injector and platelet-rich plasma therapy for hair aging in naturally aging mice.

Biomed Pharmacother 2020 Jul 21;130:110520. Epub 2020 Jul 21.

Department of Dermatology, the First Affiliated Hospital of Anhui Medical University, Anhui, Hefei 230032, China; Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, Hefei, Anhui, 230032, China; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei 230032, China. Electronic address:

The mechanism of hair loss caused by aging is related to mitochondrial dysfunction. Pep-1-mediated mitochondrial transplantation is a potential therapeutic application for mitochondrial disorders, but its efficacy against hair aging remains unknown. This study compared platelet-rich plasma (PRP) therapy with mitochondrial transplantation for hair restoration and examined the related regulation in naturally aging mice. Read More

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http://dx.doi.org/10.1016/j.biopha.2020.110520DOI Listing

Vascular Occlusion Role in the Etiopathohegenesis of Idiopathic Sudden Sensorineural Hearing Loss: Risk Analysis with Hematological Parameters.

J Coll Physicians Surg Pak 2020 Jun;30(6):606-610

Department of Otorhinolaryngology, Head and Neck Surgery, Haydarpaşa Numune Training and Research Hospital, Istanbul, Turkey.

Objective: To evaluate the concomittant metabolic disorders, mean platelet volume (MPV), and neutrophil to lymphocyte ratio (NLR) in patients with idiopathic sudden sensorineural hearingloss (SSNHL) in comparison to healthy controls.

Study Design: Case-control study.

Place And Duration Of Study: Department of Otorhinolaryngology, Head and Neck Surgery, University of Health Sciences, Haydarpaşa Numune Training and Research Hospital, Turkey, from December 2016 to May 2019. Read More

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http://dx.doi.org/10.29271/jcpsp.2020.06.606DOI Listing

The interaction between the complement system and hemostatic factors.

Curr Opin Hematol 2020 Sep;27(5):341-352

Division of Internal Medicine, Section of Benign Hematology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Purpose Of Review: To discuss the crosstalk between the complement system and hemostatic factors (coagulation cascade, platelet, endothelium, and Von Willebrand Factor), and the consequences of this interaction under physiologic and pathologic conditions.

Recent Findings: The complement and coagulation systems are comprised of serine proteases and are genetically related. In addition to the common ancestral genes, the complement system and hemostasis interact directly, through protein-protein interactions, and indirectly, on the surface of platelets and endothelial cells. Read More

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http://dx.doi.org/10.1097/MOH.0000000000000605DOI Listing
September 2020

Updates in diagnosis of the inherited platelet disorders.

Curr Opin Hematol 2020 Sep;27(5):333-340

Division of Hematology, The Children's Hospital of Philadelphia.

Purpose Of Review: To provide a comprehensive update on the current available methodologies and techniques for diagnosis of inherited platelet disorders (IPD).

Recent Findings: The contributions of many groups have resulted in the significant progress in the molecular diagnosis of IPD including the identification of many genes responsible for the various phenotypes. The widespread use and availability of next-generation sequencing has brought to the forefront ethical challenges associated with nontargeted sequencing as well as provided us with novel variants to functionally validate. Read More

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http://dx.doi.org/10.1097/MOH.0000000000000604DOI Listing
September 2020

Detection of anti-heparin-PF4 complex antibodies in COVID-19 patients on heparin therapy.

Blood Transfus 2020 07;18(4):328

Department of Hematology, "San Carlo" Regional Hospital, Potenza, Italy.

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http://dx.doi.org/10.2450/2020.0164-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375879PMC

Pulmonary Embolism, Pulmonary Microvascular Thrombosis, or Both in COVID-19?

Authors:
José A Páramo

Clin Appl Thromb Hemost 2020 Jan-Dec;26:1076029620933953

Clínica Universidad de Navarra, Pamplona, Spain.

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http://dx.doi.org/10.1177/1076029620933953DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376295PMC

Increased platelet distribution width and reduced IL-2 and IL-12 are associated with thrombocytopenia in Plasmodium vivax malaria.

Mem Inst Oswaldo Cruz 2020 17;115:e200080. Epub 2020 Jul 17.

Fundação Oswaldo Cruz-Fiocruz, Instituto Leônidas e Maria Deane, Programa de Pós-Graduação em Biologia da Relação Patógeno-Hospedeiro, Manaus, AM, Brasil.

Background: Thrombocytopenia in malaria involves platelet destruction and consumption; however, the cellular response underlying this phenomenon has still not been elucidated.

Objective: To find associations between platelet indices and unbalanced Th1/Th2/Th17 cytokines as a response to thrombocytopenia in Plasmodium vivax infected (Pv-MAL) patients.

Methods: Platelet counts and quantification of Th1/Th2/Th17 cytokine levels were compared in 77 patients with uncomplicated P. Read More

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http://dx.doi.org/10.1590/0074-02760200080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367212PMC

Analysis of clinical characteristics and outcomes in patients with COVID-19 based on a series of 1000 patients treated in Spanish emergency departments.

Emergencias 2020 Ago;32(4):233-241

Servicio de Urgencias, Hospital General Universitario de Alicante, Universidad Miguel Hernández, Elche, Alicante, Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), España.

Objectives: To describe the clinical characteristics of patients with coronavirus disease 2019 (COVID-19) treated in hospital emergency departments (EDs) in Spain, and to assess associations between characteristics and outcomes.

Material And Methods: Prospective, multicenter, nested-cohort study. Sixty-one EDs included a random sample of all patients diagnosed with COVID-19 between March 1 and April 30, 2020. Read More

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Idiopathic thrombocytopenic purpura is strongly associated with higher prevalence of aortic valve disease.

Ann Hematol 2020 Sep 20;99(9):2081-2084. Epub 2020 Jul 20.

College of Medicine, University of Arizona, Phonix, AZ, USA.

Aortic valve disease (AVD) has similarities to atherosclerosis in the case of aortic stenosis. The important role of platelet in the pathogenesis of atherosclerosis is known. The goal of this study is to evaluate whether platelet disorders play any role in aortic valve disease. Read More

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http://dx.doi.org/10.1007/s00277-020-04170-8DOI Listing
September 2020

Clinical characteristics of 312 hospitalized older patients with COVID-19 in Wuhan, China.

Arch Gerontol Geriatr 2020 Jul 15;91:104185. Epub 2020 Jul 15.

Surgury Intensive Care Unit, China-Japan Friendship Hospital, No. 2, YingHua East Street, Chaoyang District, Beijing, China. Electronic address:

Objectives: Much of the previous research on COVID-19 was based on all population. But substantial numbers of severe episodes occur in older patients. There is a lack of data about COVID-19 in older adults. Read More

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http://dx.doi.org/10.1016/j.archger.2020.104185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7361038PMC

Novel variants in the BLOC1S3 gene in patients presenting a mild form of Hermansky-Pudlak syndrome.

Pigment Cell Melanoma Res 2020 Jul 20. Epub 2020 Jul 20.

Maladies Rares: Génétique et Métabolisme (MRGM), Univ. Bordeaux, INSERM U1211, Bordeaux, France.

Hermansky-Pudlak syndrome (HPS) associates oculocutaneous albinism and systemic affections including platelet dense granules anomalies leading to bleeding diathesis and, depending on the form, pulmonary fibrosis, immunodeficiency, and/or granulomatous colitis. So far, 11 forms of autosomal recessive HPS caused by pathogenic variants in 11 different genes have been reported. We describe three HPS-8 consanguineous families with different homozygous pathogenic variants in BLOC1S3 (NM_212550. Read More

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http://dx.doi.org/10.1111/pcmr.12915DOI Listing

Platelet function in stroke/transient ischemic attack patients treated with tocotrienol.

FASEB J 2020 Jul 20. Epub 2020 Jul 20.

Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA.

The purpose of this study was to characterize the effects of tocotrienol form of vitamin E (TCT) on platelet function in patients with stroke or transient ischemic attack (TIA). A double blind, randomized, single center phase II clinical trial was conducted comparing placebo (PBO) and 400 and 800 mg TCT daily for a year in 150 patients with a sentinel ischemic stroke or TIA event in the prior 6 months. Platelet function was measured at baseline and then, at 3 month intervals for a year, using light transmission aggregometry. Read More

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http://dx.doi.org/10.1096/fj.201902216RRDOI Listing

Bleeding risks for uncharacterized platelet function disorders.

Res Pract Thromb Haemost 2020 Jul 30;4(5):799-806. Epub 2020 May 30.

Department of Pathology and Molecular Medicine McMaster University Hamilton ON Canada.

Background: The bleeding risks for nonsyndromic platelet function disorders (PFDs) that impair aggregation responses and/or cause dense granule deficiency (DGD) are uncertain.

Objectives: Our goal was to quantify bleeding risks for a cohort of consecutive cases with uncharacterized PFD.

Methods: Sequential cases with uncharacterized PFDs that had reduced maximal aggregation (MA) with multiple agonists and/or nonsyndromic DGD were invited to participate along with additional family members to reduce bias. Read More

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http://dx.doi.org/10.1002/rth2.12374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354414PMC

Illustrated State-of-the-Art Capsules of the ISTH 2020 Congress.

Res Pract Thromb Haemost 2020 Jul 12;4(5):680-713. Epub 2020 Jul 12.

Department of Cell and Developmental Biology Perelman School of Medicine University of Pennsylvania Philadelphia PA USA.

The 2020 Congress of the International Society of Thrombosis and Haemostasis (ISTH) was held virtually July 12-15, 2019, due to the coronavirus disease 2019 pandemic. The congress convenes annually to discuss clinical and basic topics in hemostasis and thrombosis. Each year, the program includes State of Art (SOA) lectures given by prominent scientists. Read More

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http://dx.doi.org/10.1002/rth2.12368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354406PMC