81,857 results match your criteria Platelet Disorders


NO/cGMP/PKG pathway in platelets:the therapeutic potential of PDE5 inhibitors in platelet disorders.

J Thromb Haemost 2022 Aug 11. Epub 2022 Aug 11.

Department of Experimental Medicine, Sapienza University of Rome, 00161, Rome, Italy.

Platelets are the "guardians" of the blood circulatory system. At sites of vessel injury, they ensure hemostasis and promote immunity and vessel repair. However, their uncontrolled activation is one of the main drivers of thrombosis. Read More

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Potential of Plasma Rich in Growth Factors (PRGF-Endoret) to Enhance the Efficacy of Assisted Reproductive Techniques in Refractory Cases.

Cureus 2022 Jul 6;14(7):e26623. Epub 2022 Jul 6.

Regenerative Medicine Laboratory, Biotechnology Institute ImasD, Instituto Eduardo Anitua, Vitoria, ESP.

Aim: Nowadays, infertility problems affect a high percentage of couples. This study aimed to evaluate the effect of plasma rich in growth factors (PRGF-Endoret, hereafter PRGF) as a promising coadjuvant therapy in assisted reproductive techniques and its possible role in implantation and pregnancy rates. This retrospective study included 36 PRGF cycles in 27 women with one of the following reproductive disorders: recurrent implantation failure (n = 16), repeated abortion (n = 8), and thin endometrium (n = 3). Read More

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The effects of ginger and its constituents in the prevention of metabolic syndrome: A review.

Iran J Basic Med Sci 2022 Jun;25(6):664-674

Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Metabolic syndrome is a multifactorial disorder characterized by hyperglycemia, hyperlipidemia, obesity, and hypertension risk factors. Moreover, metabolic syndrome is the most ordinary risk factor for cardiovascular disease (CVD). Numerous chemical drugs are being synthesized to heal metabolic risk factors. Read More

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Platelet-rich Plasma in the Management of Shoulder Disorders: Basic Science and Implications Beyond the Rotator Cuff.

J Am Acad Orthop Surg 2022 Aug 9. Epub 2022 Aug 9.

From the Department of Orthopaedic Surgery, University of Southern California Keck School of Medicine, Los Angeles CA.

Platelet-rich plasma (PRP) is an autologous mixture produced by centrifugal separation of whole blood. Understanding the clinical efficacy of PRP remains a challenge in the field of sports medicine, including the treatment of various shoulder conditions. Animal studies have examined the biologic actions of PRP on the rotator cuff tendon and shoulder capsule. Read More

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Mechanisms of ultraviolet-induced melasma formation: A review.

J Dermatol 2022 Aug 10. Epub 2022 Aug 10.

The Third Xiangya Hospital, Central South University, Changsha, China.

Melasma, a pigmentation disorder, commonly occurs in exposed skin areas and can be attributed to several factors. Ultraviolet radiation (UVR) is the primary factor that induces and aggravates melasma. Considering gene expression, exposed skin areas experience abnormal gene expression, involving melanin metabolism, oxidative stress, impaired skin barrier function, and abnormal composition of nerve factors. Read More

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Thrombocytopenia in a Hemodialysis Patient Starting Home Therapy with NxStage System One: Management in a Community Setting.

Saudi J Kidney Dis Transpl 2021 Nov-Dec;32(6):1775-1781

Clinical Sciences Division, Northern Ontario School of Medicine, Sudbury and Thunder Bay, Ontario, Canada.

Platelet dysfunction is common in individuals with advanced chronic kidney disease, and hemodialysis (HD) may cause further activation of platelets, increasing the risk of bleeding and thrombosis. Thrombocytopenia is a potential complication of HD therapy that offen is multifactorial. Both underlying patient-related or specific HD factors may be responsible. Read More

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Renal Histopathological Changes in Coronavirus Disease 2019 Patients: A Systematic Review and Meta-analysis of Individual Patient Data.

Saudi J Kidney Dis Transpl 2021 Nov-Dec;32(6):1523-1544

Department of Pharmacology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.

The major targets of coronavirus disease 2019 (COVID-19) are the respiratory and immune systems. However, a significant proportion of hospitalized patients had kidney dysfunction. The histopathological surveys have principally focused on respiratory, hematopoietic, and immune systems, whereas histopathologic data of kidney injury are lacking. Read More

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Microsurgical Breast Reconstruction in Patients with Disorders of Hemostasis - Perioperative Risks and Management.

Plast Reconstr Surg 2022 Aug 10. Epub 2022 Aug 10.

Jian Farhadi, M.D., Prof. Plastic Surgery Group; Zurich, Switzerland. University of Basel; Basel, Switzerland.

Background: Surgical and technological advances have resulted in the widespread adoption of microsurgical breast reconstruction. Many comorbidities that potentially might impair vasculature and wound healing are no longer considered contraindications for these procedures. However, some uncertainty still prevails regarding the perioperative management of patients with disorders of hemostasis. Read More

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Evaluation of advanced platelet-rich fibrin (PRF) as a bio-carrier for ampicillin/sulbactam.

Clin Oral Investig 2022 Aug 9. Epub 2022 Aug 9.

Department of Oral and Maxillofacial Plastic Surgery of the University Hospital Würzburg, Pleicherwall 2, 97070, Würzburg, Germany.

Objectives: Mechanisms of wound healing are often impaired in patients with osteonecrosis of the jaw (ONJ). According to the guidelines for the treatment of this disease, early surgical intervention is indicated. However, surgery often faces complications such as wound healing disorders. Read More

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Prevalence and outcomes of patients developing heparin-induced thrombocytopenia during extracorporeal membrane oxygenation.

PLoS One 2022 8;17(8):e0272577. Epub 2022 Aug 8.

Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Bavaria, Germany.

Objectives: Unfractionated heparin (UFH) is the commonly used anticoagulant to prevent clotting of the ECMO circuit and thrombosis of the cannulated vessels. A side effect of UFH is heparin-induced thrombocytopenia (HIT). Little is known about HIT during ECMO and the impact of changing anticoagulation in ECMO patients with newly diagnosed HIT. Read More

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Contributions of von Willebrand factor to clinical severity of sickle cell disease: a systematic review and metanalysis.

Hematology 2022 Dec;27(1):860-866

Department of Medical Laboratory Science, Faculty of Health Sciences, University of Nigeria Enugu Campus, Nsukka, Nigeria.

Aim: To evaluate the contributions of VWF to the clinical manifestation and severity of SCD.

Design: A systematic review of peer-reviewed articles published in English. The review was carried out in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist. Read More

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December 2022

Platelets and tyrosine kinase inhibitors: clinical features, mechanism of action and effects on physiology.

Am J Physiol Cell Physiol 2022 Aug 8. Epub 2022 Aug 8.

Department of Biomedical Engineering, Oregon Health & Science University, Portland, Oregon, United States.

Tyrosine kinase inhibitors (TKIs) have emerged as a promising class of target-directed, small molecule inhibitors used to treat hematologic malignancies, inflammatory diseases, and autoimmune disorders. Recently, TKIs have also gained interest as potential antiplatelet-directed therapeutics that could be leveraged to reduce pathologic thrombus formation and atherothrombotic complications, while minimally affecting platelet hemostatic function. This review provides a mechanistic overview and summarizes the known effects of tyrosine kinase inhibitors on platelet signaling and function, detailing prominent platelet signaling pathways downstream of the glycoprotein VI (GPVI) receptor, integrin αβ, and G-protein couple receptors (GPCRs). Read More

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Association Between the Neutrophil-To-Lymphocyte Ratio and Diabetes Secondary to Exocrine Pancreatic Disorders.

Front Endocrinol (Lausanne) 2022 22;13:957129. Epub 2022 Jul 22.

Department of Pancreatic Surgery, West China Hospital of Sichuan University, Chengdu, China.

Background: Diabetes mellitus among patients with exocrine pancreatic disorders is commonly known to be associated with chronic inflammation, including chronic pancreatitis and pancreatic ductal adenocarcinoma (PDAC). The neutrophil-to-lymphocyte ratio (NLR) is a novel marker that indicates the presence of various chronic inflammatory diseases, including type 2 diabetes (T2DM). However, no studies have examined the relationship between the NLR value and diabetes secondary to exocrine pancreatic disorders. Read More

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A Nomogram Model for Individualized Prediction of the Risk of Respiratory Tract Infection within Six Months after Diagnosis in Patients with Primary Immune Thrombocytopenia.

Comput Math Methods Med 2022 28;2022:5002681. Epub 2022 Jul 28.

Department of Gynecology, The People's Hospital of Hechi, Hechi, 547000 Guangxi, China.

The risk factors of upper respiratory tract infection (URI) within 6 months after diagnosis in patients with idiopathic thrombocytopenic purpura (ITP) were analyzed, and the nomogram model was established and verified, with 242 and 50 ITP patients as the training and validation set, respectively. The patients were followed up for six months after the diagnosis of ITP. The clinical data of patients were collected, and the risk factors of URI in ITP patients within six months after diagnosis were analyzed using univariable, followed by multivariable logistic regression. Read More

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Elevated neuregulin-1 levels correlate with plasma biomarkers of cerebral injury and high stroke risk in children with sickle cell anemia.

Endocr Metab Sci 2021 Jun 14;3. Epub 2021 Feb 14.

Department of Pediatrics, Morehouse School of Medicine; 720 Westview Drive SW, Atlanta, GA 30310, USA.

Stroke, or cerebral infarction, is one of the most serious complications of sickle cell anemia (SCA) in childhood, potentially leading to impaired development and life-long physical and cognitive disabilities. About one in ten children with SCA are at risk for developing overt stroke and an additional 25% may develop silent cerebral infarcts. This is largely due to underlying cerebral injury caused by chronic cerebral ischemia and vascular insult associated with SCA. Read More

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Analysis of Risk Factors of Coagulation Dysfunction and Hemorrhage in Newly Diagnosed Hyperleukocytic Acute Myeloma Leukemia.

Contrast Media Mol Imaging 2022 13;2022:7828230. Epub 2022 Jul 13.

Department of Hematology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, China.

Purpose: To explore whether and why abnormal coagulation function and hemorrhage can appear in patients with hyperleukocytic acute myeloid leukemia (HAML).

Method: We retrospectively reviewed the charts of 724 acute myeloid leukemia (AML) patients admitted with a white blood cell count of >100 × 10/L between 2010 and 2019 in order to analyze the coagulation index of patients with HAML and explore the correlation of abnormal coagulation.

Result: Prothrombin time (PT) was extended in group HAML compared with group non-HAML. Read More

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Development of clinical phenotypes and biological profiles via proteomic analysis of trauma patients.

Crit Care 2022 08 6;26(1):241. Epub 2022 Aug 6.

Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, 2-15, Yamada‑oka, Suita, Osaka, 565-0871, Japan.

Background: Trauma is a heterogeneous condition, and specific clinical phenotypes may identify target populations that could benefit from certain treatment strategies. In this retrospective study, we determined clinical phenotypes and identified new target populations of trauma patients and their treatment strategies.

Methods: We retrospectively analyzed datasets from the Japan Trauma Data Bank and determined trauma death clinical phenotypes using statistical machine learning techniques and evaluation of biological profiles. Read More

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Association of neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and monocyte to lymphocyte ratio with depression: A cross-sectional analysis of the NHANES data.

J Affect Disord 2022 Aug 4;315:168-173. Epub 2022 Aug 4.

The National Clinical Research Center for Mental Disorder & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China. Electronic address:

Background: The association of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and monocyte to lymphocyte ratio (MLR) with depression has been investigated extensively while the results were conflicting. We aim to investigate whether NLR, PLR, and MLR are associated with depression, as well as to explore the potential non-linear relationship between them.

Methods: This cross-sectional study was conducted based on representative samples of US adults from the National Health and Nutrition Examination Survey 2005-06 to 2017-18. Read More

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Arabian Levantine viper bite induces thrombocytopenia - a case report.

J Med Life 2022 Jun;15(6):867-870

Department of Hematology and Oncology, King Hussein Medical City, Amman, Jordan.

Snakebites have been reported to induce hematological complications. Thrombocytopenia usually occurs secondary to disseminated intravascular coagulation (DIC) and coagulopathy induced by the snake bite. However, thrombocytopenia can develop after the snake bite, even in the absence of significant coagulopathy. Read More

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A COVID Constellation: A Case of Transverse Myelitis and Acquired von Willebrand Syndrome.

J Investig Med High Impact Case Rep 2022 Jan-Dec;10:23247096221109205

Emory University School of Medicine, Atlanta, GA, USA.

The coronavirus disease 2019 (COVID-19) pandemic revealed a myriad of postinfectious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequelae, many of which remain poorly understood. We describe a rare presentation of a patient developing 2 simultaneous COVID-19 sequelae: transverse myelitis and acquired von Willebrand syndrome (AVWS). There have been numerous published case reports of patients developing transverse myelitis after a diagnosis of COVID-19. Read More

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Incidence of thrombotic microangiopathies in Quebec: insight from a laboratory centralizing ADAMTS-13 testing.

Orphanet J Rare Dis 2022 08 4;17(1):308. Epub 2022 Aug 4.

Division of Hematology-Oncology, CHU Sainte-Justine, Université de Montréal, 3175, chemin de la Côte-Ste-Catherine, Montreal, QC, H3T 1C5, Canada.

Background: Thrombotic microangiopathies (TMA) are serious medical conditions requiring a prompt diagnosis to adapt treatment. The determination of ADAMTS-13 activity enables discriminating thrombotic thrombocytopenic purpura (TTP) from other forms of TMA. The purpose of this study was to provide an estimate of the incidence of TTP and TMA in the Canadian Quebec province using data collected from a laboratory centralizing ADAMTS-13 testing for the whole province. Read More

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Platelets get particular.

Blood 2022 08;140(5):413-414

University of Pennsylvania Perelman School of Medicine.

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[Coagulation diagnostics in the clinical routine-part 2 : Monitoring of anticoagulation treatment, new-onset thrombocytopenia and thrombophilia].

Inn Med (Heidelb) 2022 Jul 19;63(7):736-750. Epub 2022 May 19.

Klinik und Poliklinik für Hämatologie, Zelltherapie und Hämostaseologie, Bereich Hämostaseologie, Universitätsklinikum Leipzig, Leipzig, Deutschland.

Monitoring of vitamin K antagonist treatment with the international normalized ratio (INR) is obligatory, whereas this only applies to direct oral anticoagulants (DOAC) or low molecular weight heparin in the context of selected clinical scenarios. For DOAC the focus is on the determination of trough and peak plasma levels of the drug but for low molecular weight heparins the focus is on anti-Xa activity. The timing of blood sampling in relation to drug intake is essential for the interpretation of the results. Read More

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[Differential diagnosis of reactive cytopenias].

Pathologie (Heidelb) 2022 Jul 19;43(4):263-270. Epub 2022 May 19.

Pathologie, Institut für Medizinische Genetik und Pathologie, Universitätsspital Basel, Universität Basel, Schönbeinstrasse 40, 4031, Basel, Schweiz.

Reactive cytopenias are a frequent cause for bone marrow investigations, including bone marrow trephine biopsies, especially if clinical examination and laboratory analyses (e.g., detection of substrate deficiencies) cannot provide a sufficient explanation. Read More

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Clonal evolution in hereditary thrombocytosis with MPL T487A mutation.

Pediatr Blood Cancer 2022 Aug 4:e29905. Epub 2022 Aug 4.

Adolescent and Young Adult Hematology Unit, Saint-Louis Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.

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The Value of Combined Detection of Megakaryocyte and Platelet Parameters for the Diagnosis of Primary Immune Thrombocytopenia.

Clin Appl Thromb Hemost 2022 Jan-Dec;28:10760296221106779

Department of Laboratory Medicine, the Second People's Hospital of Lianyungang City, Jiangsu Province, China.

To investigate the application value of bone marrow megakaryocyte count, the proportion of megakaryocytes at each stage, and the platelet parameter in the clinical diagnosis of primary immune thrombocytopenia (ITP). The megakaryocyte and platelet parameter level in 62 ITP and 40 control group patients were compared and analyzed. Linear correlation analysis, Pearson correlation analysis, and ROC curves were performed for the correlation between megakaryocytes and platelet parameters. Read More

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Heparin-induced thrombocytopenia post-cardiovascular interventional therapy: a case report.

BMC Cardiovasc Disord 2022 08 3;22(1):351. Epub 2022 Aug 3.

Department of Cardiology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, No. 261 Huansha Road, Shangcheng District, Hangzhou, 310016, China.

Background: Heparin-induced thrombocytopenia (HIT) is an antibody-mediated adverse drug reaction characterized by thrombocytopenia and thromboembolism. Herein, we present a case of HIT with subcutaneous hemorrhage after cardiovascular interventional therapy.

Case Presentation: A 74-year-old man was admitted to the hospital for elective atrial fibrillation (AF) catheter ablation and left atrial appendage closure because of intermittent dizziness and palpitations. Read More

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Evaluation of Obstetricians' Opinion of Thrombocytopenia in Pregnancy: A Cross-Sectional Study.

West Afr J Med 2022 Jul;39(7):657-662

Department of Obstetrics and Gynaecology. University of Port Harcourt Teaching Hospital, Port Harcourt, Rivers State, Nigeria.

Background: Thrombocytopenia occurs in about 8-10% of pregnancies. Thrombocytopenia may be incidental in pregnancy and could point to medical or gestational conditions that may pose a morbidity and mortality risk to both mother and foetus.

Aim: To determine Obstetricians' view/opinion about thrombocytopenia in pregnancy. Read More

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Biological Targets of Multimolecular Therapies in Middle-Age Osteoarthritis.

Sports Med Arthrosc Rev 2022 Sep 3;30(3):141-146. Epub 2022 Aug 3.

Department of Musculoskeletal Disorders, University of Salerno School of Medicine and Dentistry, Salerno, Italy.

Knee osteoarthritis (OA) is a common condition, prevalent in middle-agedness, associated with chronic pain and impaired quality of life. Two interrelated biological processes fuel early OA progression: inflammation and structural tissues catabolism. Procatabolic and proinflammatory mediators are interconnected and form part of a self-perpetuating loop. Read More

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September 2022

[Platelet variation coefficient and its prognostic value in acute pancreatitis].

Khirurgiia (Mosk) 2022 (8):38-44

Tula State University, Tula, Russia.

Objective: To evaluate the role of platelet variation coefficient in prediction of severity of acute pancreatitis (AP).

Material And Methods: The study included 90 patients with AP who admitted to the Tula City Emergency Hospital between 2018 and 2019. Patients had no signs of renal and hepatic insufficiency, cancer, blood diseases, inherited platelet disorders, previous splenectomy, antiplatelet and anticoagulant therapy. Read More

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