1,512 results match your criteria Plasmacytoma Extramedullary


Solitary Plasmacytoma: a Review of Diagnosis and Management.

Curr Hematol Malig Rep 2019 Feb 20. Epub 2019 Feb 20.

Scripps Clinic, 10666 N Torrey Pines Road, MS312, La Jolla, CA, 92037, USA.

Purpose Of Review: Solitary plasmacytoma is a rare plasma cell dyscrasia, classified as solitary bone plasmacytoma or solitary extramedullary plasmacytoma. These entities are diagnosed by demonstrating infiltration of a monoclonal plasma cell population in a single bone lesion or presence of plasma cells involving a soft tissue mass, respectively. Both diseases represent a single localized process without significant plasma cell infiltration into the bone marrow or evidence of end organ damage. Read More

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http://dx.doi.org/10.1007/s11899-019-00499-8DOI Listing
February 2019

[A Case of Extramedullary Plasmacytoma of the Stomach Detected Due to Severe Anemia].

Gan To Kagaku Ryoho 2019 Jan;46(1):100-102

Dept. of Surgery, Suita Municipal Hospital.

A 78-year-oldwoman was referredfor exertional dyspnea. Severe anemia(Hb 4.2 g/dL)was detected, and upper endoscopy revealeda giant ulcer at the posterior wall of the gastric body. Read More

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January 2019
3 Reads

Extramedullary plasmacytoma of tonsil: an unusual site.

Indian J Pathol Microbiol 2019 Jan-Mar;62(1):167-168

Department of Pathology, Lab Medicine and Transfusion Medicine, Medanta - The Medicity Hospital, Gurgaon, Haryana, India.

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http://dx.doi.org/10.4103/IJPM.IJPM_808_17DOI Listing
February 2019
1 Read
0.642 Impact Factor

Extramedullary plasmacytoma of the right main bronchus.

Ann Thorac Surg 2019 Jan 22. Epub 2019 Jan 22.

Medical University of South Carolina, Department of Surgery, Division of Cardiothoracic Surgery. Electronic address:

Extramedullary plasmacytomas (EMP) are rare tumors that typically involve the head and neck region. Only 3 reports exist in the literature of EMP involving the lower airways. We report the case of a 54-year-old female with EMP of the right mainstem bronchus treated with sleeve resection. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2018.12.026DOI Listing
January 2019
2 Reads

Primary plasmablastic plasmacytoma in the stomach of an immunocompetent adult: A case report.

Medicine (Baltimore) 2019 Jan;98(4):e14235

Department of General Surgery.

Rationale: Extramedullary plasmacytomas (EMP) are tumors composed by a monoclonal population of plasma cells that arise in extraosseus tissues, occupying <5% of all plasma cell neoplasms. Gastrointestinal solitary extramedullary plasmacytoma is rare, just comprises about 5% of all EMPs. The most common site is small intestine. Read More

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http://dx.doi.org/10.1097/MD.0000000000014235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358359PMC
January 2019
1 Read
5.723 Impact Factor

Plasma Cell Myeloma - 20-Year Comparative Survival and Mortality of Three Plasma Cell Myeloma ICD-O-3 Oncologic Phenotypes by Age, Sex, Race, Stage, Cohort Entry Time-Period and Disease Duration: A Systematic Review of 111,041 Cases for Diagnosis Years 1973--2014: (SEER*Stat 8.3.4).

Authors:
Anthony F Milano

J Insur Med 2019 Jan 22. Epub 2019 Jan 22.

Background: -The values of SEER site recode variables are based on the primary site and histology data fields submitted to SEER by the registries. The site recode variables define the major cancer site/histology groups that are commonly used in the reporting of cancer incidence data and are added to the SEER databases as a convenience for researchers. These codes and definitions are periodically updated and changed by the National Cancer Institute as newer and more applicable information becomes available. Read More

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http://dx.doi.org/10.17849/insm-47-04-1-9.1DOI Listing
January 2019
1 Read

Efficacy of Carfilzomib, Lenalidomide, and Dexamethasone for Extramedullary Intracranial Localization of Multiple Myeloma.

Case Rep Hematol 2018 29;2018:2312430. Epub 2018 Nov 29.

Department of Haematology and BMT Unit, Antonio Perrino Hospital, Brindisi, Italy.

EMD of myeloma usually occurs several years after diagnosis and is associated with a very poor OS of <6 months due to the fact that there are no efficient treatment options. In rrMM with EMDs, the most effective treatment is a lymphoma-like polychemotherapy regimen such as PACE, Dexa-BEAM, and HyperCVAD followed by ASCT or allogeneic SCT. RT of soft-tissue plasmacytoma is the further treatment choice and results in a high rate of local control and a prolonged disease-free survival. Read More

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http://dx.doi.org/10.1155/2018/2312430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304832PMC
November 2018
5 Reads

Diagnosis of solitary extramedullary plasmacytoma located in the nasopharynx in a patient with acquired angioedema.

Postepy Dermatol Alergol 2018 Dec 13;35(6):636-637. Epub 2018 Nov 13.

Department of Allergology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland.

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http://dx.doi.org/10.5114/ada.2018.77616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320481PMC
December 2018
1 Read

[Successful Treatment with Pomalidomide, Bortezomib, and Dexamethasone in a Patient with Frail Refractory and Relapsed Multiple Myeloma with Extramedullary Disease].

Gan To Kagaku Ryoho 2018 Dec;45(12):1779-1782

Division of Hematology, Japanese Red Cross Society Wakayama Medical Center.

An 85-year-old female was diagnosed with multiple myeloma(MM)(IgG-l)with t(4 ;14)(p16;q32)in 200X. She received bortezomib with dexamethasone(Vd)therapy and lenalidomide with dexamethasone(Ld)therapy, and she subsequently maintained a very good partial response(VGPR). On day 731, she experienced relapse and was treated with 2 courses of elotuzumab with Ld therapy. Read More

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December 2018
2 Reads

Secondary extramedullary plasmacytoma of sigmoid colon in a patient with multiple myeloma: a case report.

J Med Case Rep 2018 Dec 25;12(1):379. Epub 2018 Dec 25.

Computed Tomography Department, Konstantpouleio General Hospital Nea Ionia, Athens, Greece.

Background: Extramedullary plasmacytoma is an uncommon tumor that most often involves the nasopharynx or upper respiratory tract. Extramedullary plasmacytoma is a type of plasma cell neoplasm that can present as a primary tumor or secondary to another plasma cell neoplasm, such as multiple myeloma. Secondary extramedullary plasmacytoma is usually noted in the advanced stages of the disease. Read More

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http://dx.doi.org/10.1186/s13256-018-1888-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305571PMC
December 2018
2 Reads

Distinct promoter methylation profile reveals spatial epigenetic heterogeneity in 2 myeloma patients with multifocal extramedullary relapses.

Clin Epigenetics 2018 Dec 20;10(1):158. Epub 2018 Dec 20.

Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam Road, Pokfulam, Hong Kong.

Spatial and subclonal genetic heterogeneity in multiple myeloma (MM) have been demonstrated by sequencing of plasma cells from multi-focal regions, but studies of spatial epigenetic heterogeneity are scanty. Herein, promoter methylation status of genes implicated in disease progression (CDKN2A and SHP1) and marrow escape (CDH1, CD56, and CXCR4) was studied in two patients with multi-focal extramedullary relapses. Patient 1 developed simultaneous chest wall and duodenal plasmacytoma at relapse. Read More

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http://dx.doi.org/10.1186/s13148-018-0597-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302381PMC
December 2018
1 Read

Vertebral solitary bone plasmacytoma in a young adult with Trisomy 21: A case report.

J Spinal Cord Med 2018 Dec 17:1-4. Epub 2018 Dec 17.

a Neurology's Department , Habib Bourguiba Hospital , Sfax , Tunisia.

Context: Solitary bone plasmacytoma (SBP) are rare lesions, accounting for less than 5% of all plasma cell proliferations. We describe a case of a 21-year-old female with Trisomy 21 presenting with cauda equina compression from an SBP.

Findings: Solitary bone plasmacytoma (SBP) is a rare primary bone tumor. Read More

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https://www.tandfonline.com/doi/full/10.1080/10790268.2018.1
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http://dx.doi.org/10.1080/10790268.2018.1557866DOI Listing
December 2018
7 Reads

Sudden and unexpected death due to intracranial sellar extramedullary plasmacytoma.

J Forensic Leg Med 2019 Feb 26;61:89-91. Epub 2018 Nov 26.

Institute od Pathology, Faculty of Medicine, Slovak Medical University and Cytopathos Ltd., Limbova 12, 833 03 Bratislava, Slovakia. Electronic address:

The incidence of sudden death caused by undiagnosed primary intracranial neoplasm in young adults is extremely low. The aim of the work is to present a case report of the sudden death of a 24-year-old woman. The autopsy has revealed enlargement of sella turcica with an intrasellar tumorous mass extending into the adjacent basal parts of the brain. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1752928X183007
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http://dx.doi.org/10.1016/j.jflm.2018.11.012DOI Listing
February 2019
2 Reads

Retroperitoneal extramedullary plasmacytoma: A case report and review of the literature.

Medicine (Baltimore) 2018 Nov;97(46):e13281

First Department of Thoracic Radiotherapy, Shanxi Cancer Hospital, Taiyuan, China.

Rationale: The incidence of extramedullary plasmacytoma (EMP) accounts for 3% to 4% of all cases of generalized plasmacytoma. The most common pathogenic sites are the head and the neck. It is noteworthy that the pathogenic site in this case is extraperitoneal, which is uncommon in clinical practice. Read More

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http://dx.doi.org/10.1097/MD.0000000000013281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257441PMC
November 2018
11 Reads
5.723 Impact Factor

Classification of Solitary Plasmacytoma, Is it more Intricate than Presently Suggested? A Commentary.

J Cancer 2018 10;9(21):3894-3897. Epub 2018 Oct 10.

Hematopathology Service, Pathology Department, Soroka Univ. Med. Ctr. and Faculty of Health Sciences, Ben Gurion University of the Negev, Beer-Sheva, Israel.

A query regarding the definition and the classification of solitary plasmacytoma is apparently still pending. The clinical course, the response to treatment and the propensity to progress to plasma cell myeloma, are all a function of the classification which must be established on a firm basis. Solitary plasmacytoma should be recognized in the continuum of the plasma cell neoplasms. Read More

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http://www.jcancer.org/v09p3894.htm
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http://dx.doi.org/10.7150/jca.26854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218765PMC
October 2018
15 Reads

Surgery for Pulmonary Fungal Infections Complicating Hematological Malignancies.

Korean J Thorac Cardiovasc Surg 2018 Oct 5;51(5):350-355. Epub 2018 Oct 5.

Department of General Thoracic Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital.

Background: The complication rate of fungal disease is higher among patients with hematological malignancies. We investigated the clinicobacteriological outcomes of resected pulmonary fungal infections complicating hematological malignancies.

Methods: Between 2001 and 2017, 21 patients with pulmonary fungal infections complicating hematological malignancies underwent resection, and their clinical records and survival were retrospectively reviewed. Read More

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http://www.kjtcvs.org/journal/view.html?doi=10.5090/kjtcs.20
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http://dx.doi.org/10.5090/kjtcs.2018.51.5.350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200165PMC
October 2018
12 Reads

Place of Sterotactic Radiotherapy in Treatment of Extramedullary Plasmocytoma.

J Craniofac Surg 2018 Nov;29(8):e807

Kayseri Education and Research Hospital, Department of Radiation Oncology, Kayseri, Turkey.

In conclusion, extramedullary plasmacytoma (EMPs) initially develop as localized disease. These tumors are quite sensitive to radiotherapy (RT) and the response is often complete recovery after RT. In addition, highly sensitive, conformal radiosurgery can be preferred to conventional RT; however, further studies are needed to define indications and therapeutic fractions in stereotactic RT of plasmacytoma since guidelines and clinical trials are lacking. Read More

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http://dx.doi.org/10.1097/SCS.0000000000004844DOI Listing
November 2018
5 Reads

Plasmacytoma-like post-kidney-transplant lymphoproliferative disorder confined to renal allograft and urinary tract: A case report.

Nephrol Ther 2018 Dec 6;14(7):544-547. Epub 2018 Oct 6.

Service de néphrologie, CHU de Rennes, site Pontchaillou, 2, rue Henri le Guilloux, 35033 Rennes cedex 9, France.

Post-transplantation lymphoproliferative disorder (PTLD) is a well-know complication after organ transplantation. We report a case of a patient who developed an extramedullary plasmacytoma-like PTLD around his transplanted kidney treated with standard multiple myeloma chemotherapy. Three years after benefiting of a deceased donor kidney transplant for an end stage kidney disease secondary to nephroangiosclerosis, our patient developed an extra-medullary plasmacytoma confined to the transplant compartment. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17697255183056
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http://dx.doi.org/10.1016/j.nephro.2018.07.404DOI Listing
December 2018
15 Reads

[Extramedullary Plasmacytoma].

Rofo 2018 Nov 8;190(11):1006-1009. Epub 2018 Oct 8.

Diagnostic and Interventional Radiology, Universität Leipzig Medizinische Fakultät, Leipzig, Germany.

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0604-2831
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http://dx.doi.org/10.1055/a-0604-2831DOI Listing
November 2018
3 Reads

[A case of extramedullary plasmacytoma of the nasal cavity].

Authors:
M X Huo Z Liu Q X Liu

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Aug;32(15):1194-1195

A case of extramedullary plasmacytoma of the nasal cavity was reported and its mainly clinical manifestations were nasal obstruction, running nose and olfactory degeneration. Nasal endoscopy and paranasal sinus CT indicated tract tumor in left nasal (the nature to be investigated), the pathological result after surgical resection of the tumor suggests extramedullaryplasmacytoma (left nasal cavity).Clinical diagnosis was extramedullaryplasmacytoma (left nasal cavity), chronic sinusitis (left). Read More

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http://www.cnki.net/kcms/doi/10.13201/j.issn.1001-1781.2018.
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http://dx.doi.org/10.13201/j.issn.1001-1781.2018.15.017DOI Listing
August 2018
1 Read

Solitary Extramedullary Plasmacytoma Mimicking Acute Subdural Hematoma.

World Neurosurg 2018 Dec 27;120:521-524. Epub 2018 Sep 27.

Department of Neurosurgery, University of Health Sciences, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey.

Background: Solitary extramedullary plasmacytoma (SEP) is a plasma cell neoplasm located outside the bone. It is rarely observed in the intracranial area. It is very difficult to diagnose this condition radiologically before surgery. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.09.151DOI Listing
December 2018
4 Reads

Pancreatic Extramedullary Plasmacytoma Presenting as a Pancreatic Mass.

Clin Med Insights Gastroenterol 2018 24;11:1179552218801603. Epub 2018 Sep 24.

Department of Gastroenterology, Sinai Hospital, Baltimore, MD, USA.

Extramedullary plasmacytomas (EMP) are a subcategory of plasma cell neoplasm that involves organs outside the bone marrow. Involvement of the pancreas is relatively rare, reported in only 2.3% of autopsies. Read More

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http://dx.doi.org/10.1177/1179552218801603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153524PMC
September 2018
7 Reads

Solitary extramedullary plasmacytoma of the rectum complicating ulcerative colitis.

Clin J Gastroenterol 2018 Sep 20. Epub 2018 Sep 20.

Department of Pathology, Nikko Medical Center, Dokkyo Medical University, Tochigi, Japan.

Solitary extramedullary plasmacytoma (EMP) arising in the rectum is an extremely rare clinical entity. Only ten cases have been reported in the English-language literature. We experienced a case of an EMP in the rectum of a 55-year-old man with an 8-year history of proctitis-type ulcerative colitis (UC). Read More

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http://link.springer.com/10.1007/s12328-018-0907-8
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http://dx.doi.org/10.1007/s12328-018-0907-8DOI Listing
September 2018
8 Reads

Clinico-radiologic features and management of hematological tumors in the breast: a case series.

Breast Cancer 2018 Sep 18. Epub 2018 Sep 18.

Texas A&M Health Sciences Center, Dallas, TX, 75246, USA.

Hematological tumors arising in the breast are uncommon and require different treatment modalities dependent upon tumor type. Current treatment options include surgical excision, chemotherapy, and radiotherapy. Management of these breast malignancies are poorly outlined in the literature. Read More

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http://dx.doi.org/10.1007/s12282-018-0906-0DOI Listing
September 2018
6 Reads

Plasmacytoma of the mesentery.

J Postgrad Med 2018 Oct-Dec;64(4):255-257

Department of Medical Oncology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India.

Extramedullary plasmacytoma represents 3%-5% of all plasma cell neoplasms. Plasmacytomas of the mesentery are extremely rare. We report the case of a 56-year-old man who presented with an abdominal mass and was diagnosed to have plasmacytoma of the mesentery. Read More

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http://dx.doi.org/10.4103/jpgm.JPGM_296_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198696PMC
September 2018
10 Reads

Recurrence of Extramedullary Plasmacytomas Involving Lymph Nodes and Pancreas Revealed by 68Ga-DOTATATE and 18F-FDG PET/CT.

Clin Nucl Med 2018 Dec;43(12):936-938

Department of Hematology, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing, People's Republic of China.

A 40-year-old man with history of extramedullary plasmacytoma in nasal cavity presented with right submandibular mass for 3 months. F-FDG PET/CT demonstrated mild radioactivity in the right submandibular mass, pancreatic mass, and lymph nodes in the abdomen and left hilum of the lung. To differentiate from pancreatic neuroendocrine tumor, Ga-DOTATATE PET/CT was performed. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002269DOI Listing
December 2018
7 Reads

Concomitant Extramedullary Plasmacytoma in the Oropharynx and Hypopharyngeal Squamous Cell Carcinoma.

Case Rep Otolaryngol 2018 31;2018:1463218. Epub 2018 Jul 31.

Department of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University, Tokyo, Japan.

We report a rare case of hypopharyngeal squamous cell carcinoma occurring synchronously with extramedullary plasmacytoma (EPM) of the oropharynx in which radiotherapy was used as the curative treatment. A 73-year-old man presented with a sore throat that had persisted for 6 months. Examination revealed a superficial, smooth tumorous lesion at the base of his tongue with a red hue in the oropharynx. Read More

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http://dx.doi.org/10.1155/2018/1463218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091365PMC
July 2018
10 Reads

Extramedullary plasmacytoma of the larynx: Literature review and report of a case who subsequently developed acute myeloid leukemia.

Oncol Lett 2018 Sep 19;16(3):2995-3004. Epub 2018 Jun 19.

Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.

Extramedullary plasmacytoma (EMP) of the larynx is an extremely rare plasma cell neoplasm outside of the bone marrow, which has not been previously well characterized. A case of laryngeal EMP who developed acute myeloid leukemia (AML) following treatment is described in the present study, as well as an extensive review of the relevant literature. An electronic literature search was performed in PubMed and all pertinent case reports and series in the English language from 1948-October 2017 were identified. Read More

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http://dx.doi.org/10.3892/ol.2018.8992DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096153PMC
September 2018
2 Reads

A Case of Multiple Myeloma Associated with Extramedullary Plasmacytoma of the Gallbladder Manifesting as Acute Cholecystitis.

Cureus 2018 May 25;10(5):e2688. Epub 2018 May 25.

Department of Internal Medicine-Gastroenterology, Henry Ford Health System, DETROIT, USA.

Multiple myeloma (MM) is a common hematological malignancy that represents 1% of all cancers. MM is distinguished from other plasma cell disorders by prominent bone marrow involvement and systemic organ damage. Extramedullary plasmacytomas of the gall bladder (GB) or biliary ducts, whether solitary or in association with MM, are very rare. Read More

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http://dx.doi.org/10.7759/cureus.2688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6059516PMC
May 2018
5 Reads

Extramedullary Plasmacytoma of the Pancreas Complicated with Left-Sided Portal Hypertension-a Case Report and Literature Review.

J Gastrointest Cancer 2018 Jul 23. Epub 2018 Jul 23.

Department of Internal Medicine, 1st Medical Faculty Charles University and Central Military Hospital Prague, U Vojenské nemocnice 1200, 169 02, Prague, Czech Republic.

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http://dx.doi.org/10.1007/s12029-018-0146-8DOI Listing
July 2018
5 Reads

Nasal plasmacytoma: a rare cause of persistent epistaxis.

Postgrad Med 2018 Aug 25;130(6):507-510. Epub 2018 Jul 25.

d Department of Medicine, Division of Hospital Medicine , Johns Hopkins School of Medicine , Baltimore , MA , USA.

Extramedullary plasmacytoma (EP) is a rare neoplasm characterized by monoclonal proliferation of plasma cells without features of multiple myeloma. EP constitutes 3% of all plasma cell tumors. Most of the cases of EP occur in the head and neck regions, especially in the aerodigestive tract. Read More

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http://dx.doi.org/10.1080/00325481.2018.1502015DOI Listing
August 2018
24 Reads

Five cases of orbital extramedullary plasmacytoma: diagnosis and management of an aggressive malignancy.

Orbit 2018 Jul 9:1-8. Epub 2018 Jul 9.

a Faculty of Medicine , University of New South Wales , Sydney, Australia.

Purpose: Multiple myeloma is an insidious haematological malignancy characterised by monoclonal proliferation of plasma cells in the bone marrow. Extramedullary plasmacytoma is a rare manifestation of multiple myeloma and usually occurs in the upper respiratory tract. Orbital involvement is particularly uncommon, but may be associated with devastating visual impairment and poor clinical outcomes. Read More

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http://dx.doi.org/10.1080/01676830.2018.1490437DOI Listing
July 2018
17 Reads

Multiple myeloma causing interstitial pulmonary infiltrates and soft-tissue plasmacytoma.

Respir Med Case Rep 2018 19;24:155-157. Epub 2018 May 19.

Indiana University School of Medicine, USA.

Multiple Myeloma (MM) is a relatively rare disease and MM presenting outside the bone marrow, known as extramedullary myeloma (EMM), is rarer still. While the liver and CNS are most commonly affected in EMM, the lung parenchyma is an especially unusual site of involvement. We present the case of a 64-year-old male with known history of MM admitted with acute respiratory failure and a chest wall mass. Read More

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http://dx.doi.org/10.1016/j.rmcr.2018.05.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010646PMC
May 2018
2 Reads

Radiation Therapy for Solitary Plasmacytoma and Multiple Myeloma: Guidelines From the International Lymphoma Radiation Oncology Group.

Int J Radiat Oncol Biol Phys 2018 Jul 20;101(4):794-808. Epub 2018 Jun 20.

Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York.

Purpose: To develop guidelines for the work-up and radiation therapy (RT) management of patients with plasma cell neoplasms.

Methods And Materials: A literature review was conducted covering staging, work-up, and RT management of plasma cell neoplasms. Guidelines were developed through consensus by an international panel of radiation oncologists with expertise in these diseases, from the International Lymphoma Radiation Oncology Group. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2018.05.009DOI Listing
July 2018
32 Reads

Successful retreatment with lenalidomide for relapsed and refractory multiple myeloma previously treated with bortezomib, lenalidomide and pomalidomide.

J Clin Pharm Ther 2018 Dec 4;43(6):914-917. Epub 2018 Jul 4.

Division of Hematology, Japanese Red Cross Society Wakayama Medical Center, Wakayama, Japan.

What Is Known And Objectives: Optimal strategies for treating patients with very advanced relapsed and refractory multiple myeloma (RRMM) have not been clarified.

Case Summary: A 80-year-old patient with RRMM experienced extramedullary relapse following treatment with bortezomib, lenalidomide and pomalidomide. However, he achieved very good partial remission after retreatment with lenalidomide. Read More

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http://dx.doi.org/10.1111/jcpt.12740DOI Listing
December 2018
6 Reads

Solitary plasmacytoma of the jaws: therapeutical considerations and prognosis based on a case reports systematic survey.

Braz J Otorhinolaryngol 2018 Nov - Dec;84(6):790-798. Epub 2018 Jun 11.

Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Faculdade de Odontologia, Departamento de Cirurgia Bucomaxilofacial, Porto Alegre, RS, Brazil.

Introduction: Solitary plasmacytoma is a rare malignant tumor of plasma cells with no evidence of systemic proliferation. There are two known subtypes: extramedullary solitary plasmacytoma and solitary bone plasmacytoma. The etiology is still unknown. Read More

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http://dx.doi.org/10.1016/j.bjorl.2018.05.002DOI Listing
December 2018
4 Reads

Circulating Tumour DNA Analysis for Tumour Genome Characterisation and Monitoring Disease Burden in Extramedullary Multiple Myeloma.

Int J Mol Sci 2018 Jun 24;19(7). Epub 2018 Jun 24.

Myeloma Research Group, Australian Centre for Blood Diseases, Alfred Hospital⁻Monash University, Melbourne 3004, Australia.

Mutational characterisation in extramedullary multiple myeloma (EM-MM) patients is challenging due to inaccessible EM plasmacytomas, unsafe nature of multiple biopsies and the spatial and temporal genomic heterogeneity apparent in MM (Graphical abstract). Conventional monitoring of disease burden is through serum markers and PET-CT, however these modalities are sometimes inadequate (serum markers), not performed in a timely manner (PET-CT) and uninformative for identifying mutations driving disease progression. DNA released into the blood by tumour cells (ctDNA) contains the predominant clones derived from the multiple disease foci. Read More

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http://dx.doi.org/10.3390/ijms19071858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073672PMC
June 2018
8 Reads
2.862 Impact Factor

Tonsillar Plasmacytoma: clues on magnetic resonance imaging.

BMC Med Imaging 2018 06 18;18(1):19. Epub 2018 Jun 18.

Department of Pathology, Beykent University Medical Faculty, Istanbul, Turkey.

Background: Malignant plasma cell proliferation may present as a disseminated disease (multiple myeloma), a solitary plasmacytoma of bone, or an extramedullary plasmacytoma of soft tissue. The latter plasmacytomas represent approximately 3% of all plasma cell proliferations, and 80% develop in the head-and-neck region. The unexpected clinical presentation of such masses may be present. Read More

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http://dx.doi.org/10.1186/s12880-018-0261-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006941PMC
June 2018
8 Reads

Clinical Course of a Patient With Kidney Failure Due to Isolated Bilateral Renal Extramedullary Plasmacytomas.

Am J Kidney Dis 2018 Nov 6;72(5):752-755. Epub 2018 Jun 6.

Department of Biological Sciences and WWAMI Medical Education Program, University of Idaho, Moscow, ID. Electronic address:

Plasmacytomas are rare immunoproliferative monoclonal plasma cell diseases of lymphoid lineage that may present in an isolated or systemic manner. Systemic involvement is much more common than occurrences isolated to a particular organ, and for this reason, it is imperative to rule out systemic involvement for osseous and nonosseous isolated neoplasms. These neoplasms present unique challenges due to their location, extent of involvement, vague presentation, and dearth of treatment protocol. Read More

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http://dx.doi.org/10.1053/j.ajkd.2018.03.029DOI Listing
November 2018
26 Reads

Testicular plasmacytoma misdiagnosed as orchitis.

BMJ Case Rep 2018 Jun 4;2018. Epub 2018 Jun 4.

Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Testicular plasmacytomas are rare, accounting for only 1.3% of all extramedullary plasmacytomas. The infrequency in which it is encountered, coupled with its non-specific clinical and sonographic presentation, makes its diagnosis a challenge. Read More

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http://dx.doi.org/10.1136/bcr-2017-222046DOI Listing
June 2018
6 Reads

A Case of Concurrent Gastric and Pancreatic Plasmacytomas in a Patient With Multiple Myeloma: An Extremely Rare Entity.

J Investig Med High Impact Case Rep 2018 Jan-Dec;6:2324709618777003. Epub 2018 May 24.

The Brooklyn Hospital Center, Clinical Affiliate of the Mount Sinai Hospital, Brooklyn, NY, USA.

Multiple myeloma (MM), a plasma cell tumor, is primarily a disease of the bone marrow. Extramedullary plasmacytoma, also a plasma cell tumor, is very rare in the gastrointestinal tract and the pancreas, and only a handful cases have been documented till now. Gastric and pancreatic plasmacytomas are usually seen in elderly patients; however, cases in patients as young as 32 years of age have been reported. Read More

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http://dx.doi.org/10.1177/2324709618777003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971378PMC
May 2018
3 Reads

Nonepithelial Neoplasms of the Pancreas, Part 2: Malignant Tumors and Tumors of Uncertain Malignant Potential From the Radiologic Pathology Archives.

Radiographics 2018 Jul-Aug;38(4):1047-1072. Epub 2018 May 22.

From the American Institute for Radiologic Pathology, 1100 Wayne Ave, Suite 1010, Silver Spring, MD 20910 (M.A.M.); Department of Radiology, MedStar Georgetown University Hospital, Washington, DC (M.A.M.); Pathology and Laboratory Medicine Service, VA Medical Center, Washington, DC (E.E.P.); Department of Pathology, George Washington University School of Medicine and Health Sciences, Washington, DC (E.E.P.); Department of Radiology, MetroWest Medical Center, Framingham, Mass (A.S.); and Department of Radiology, Beth Israel Deaconess Medical Center, Boston, Mass (K.J.M.).

Almost all neoplasms of the pancreas are derived from pancreatic epithelial components, including the most common pancreatic mass, primary pancreatic ductal adenocarcinoma (PDAC). Nonepithelial neoplasms comprise only 1%-2% of all pancreatic neoplasms. Although some may arise directly from intrapancreatic elements, many originate from mesenchymal, hematopoietic, or neural elements in the retroperitoneal peripancreatic space and grow into the pancreas. Read More

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http://dx.doi.org/10.1148/rg.2018170201DOI Listing
October 2018
5 Reads

The role of initial F-FDG PET/CT in the management of patients with suspected extramedullary plasmocytoma.

Cancer Imaging 2018 May 15;18(1):19. Epub 2018 May 15.

Department of Nuclear Medicine, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, 510060, People's Republic of China.

Background: Extramedullary plasmacytoma (EMP) is a plasma cell malignancy that originates in soft tissues without evidence of systemic spread, and its management differs from other plasma cell neoplasms. The purpose of the present study was to evaluate the role of initial F-FDG PET/CT in the management of patients with clinical suspected EMP.

Methods: F-FDG PET/CT scans performed in 21 patients (M/F = 12/9, mean age 51. Read More

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http://dx.doi.org/10.1186/s40644-018-0152-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952599PMC
May 2018
6 Reads

Autologous stem cell transplantation in EBV-positive post-renal transplant refractory multiple myeloma: A case report and literature review.

Oncol Lett 2018 May 12;15(5):7207-7214. Epub 2018 Mar 12.

Department of Hematology, The First People's Hospital of Changzhou, The Third Affiliated Hospital of Suzhou University, Changzhou, Jiangsu 213003, P.R. China.

Renal transplant recipients exhibit an increased risk of developing plasma cell neoplasms (PCNs; comprising multiple myeloma and plasmacytoma); however, multiple myeloma manifesting with refractory extramedullary plasmacytomas associated with Epstein-Barr virus are markedly rare in these patients. In the present case report, an unusual case of refractory multiple myeloma with multiple extramedullary plasmacytoma (including liver, vertebrae, breast, muscle, skin and soft tissues) was presented. The patient exhibited mild bone marrow infiltration which was successfully treated with novel agents, including bortezomib and lenalidomide, followed by autologous stem cell transplantation (ASCT). Read More

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http://dx.doi.org/10.3892/ol.2018.8237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921225PMC
May 2018
5 Reads

Gastrointestinal manifestations of extramedullary plasmacytoma: a narrative review and illustrative case reports.

Ann R Coll Surg Engl 2018 May 25;100(5):371-376. Epub 2018 Apr 25.

Department of Soft Tissue Sarcoma, Queen Elizabeth Hospital , Birmingham , UK.

Introduction Solitary extramedullary plasmacytoma are rare, solid-mass tumours which appear immunophenotypically similar to multiple myeloma. The diagnosis and management of gastrointestinal plasmacytoma is complex and requires multidisciplinary input. This study presents a narrative review of intra-abdominal extramedullary plasmacytoma, illustrated with two case studies. Read More

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http://dx.doi.org/10.1308/rcsann.2018.0015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956591PMC
May 2018
10 Reads

How We Manage Patients with Plasmacytomas.

Curr Hematol Malig Rep 2018 06;13(3):227-235

Department of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

Purpose Of Review: To discuss the diagnostic approach, treatment options, and future considerations in the management of plasmacytomas, either solitary or in the context of overt multiple myeloma (MM).

Recent Findings: Advanced imaging techniques such as whole-body magnetic resonance imaging and positron emission tomography/computerized tomography are essential for the diagnostic workup of solitary plasmacytomas (SP) to rule out the presence of other disease foci. The role of flow cytometry and clonal plasma cell detection is currently under study together with other prognostic factors for the identification of patients with SP at high risk of progression to overt MM. Read More

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http://link.springer.com/10.1007/s11899-018-0452-z
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http://dx.doi.org/10.1007/s11899-018-0452-zDOI Listing
June 2018
17 Reads

Treatment approaches and outcomes in plasmacytomas: analysis using a national dataset.

Leukemia 2018 Jun 21;32(6):1414-1420. Epub 2018 Mar 21.

Division of Hematology, Mayo Clinic, Rochester, MN, USA.

Solitary plasmacytomas are uncommon plasma cell disorders, which may present as a single bone lesion (P-bone) or extramedullary plasmacytoma (P-EM). There is a paucity of large studies analyzing prognostic factors and outcomes of plasmacytomas. While the treatment of choice is radiation therapy (RT), there is a lack of data evaluating optimal RT dose. Read More

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http://dx.doi.org/10.1038/s41375-018-0099-8DOI Listing
June 2018
8 Reads

Durable treatment response of relapsing CNS plasmacytoma using intrathecal chemotherapy, radiotherapy, and Daratumumab.

Clin Case Rep 2018 04 2;6(4):723-728. Epub 2018 Mar 2.

Department of Radiology University Hospital Waterford Waterford Ireland.

CNS myelomatous involvement is a rare complication of multiple myeloma with dismal outcome. This disease's optimal treatment is unclear. Combined approach of systemic therapy, radiotherapy, and intrathecal injections chemotherapy should be considered and autologous stem cell transplant consolidation is offered to eligible patients. Read More

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http://dx.doi.org/10.1002/ccr3.1451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889271PMC
April 2018
5 Reads