1,582 results match your criteria Plasmacytoma Extramedullary


Primary Plasma Cell Neoplasm of the Kidney Without Formation of a Mass and Its Renal Manifestations: An Interstitial Variant of Renal Plasmacytoma?

Clin Lymphoma Myeloma Leuk 2020 May 16. Epub 2020 May 16.

Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR. Electronic address:

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http://dx.doi.org/10.1016/j.clml.2020.05.007DOI Listing

Diffuse skeletal muscle extramedullary plasmacytomas: a rare case and review of the literature.

Skeletal Radiol 2020 Jun 19. Epub 2020 Jun 19.

Wilford Hall Ambulatory Surgical Center, 1100 Wilford Hall Loop, BLDG 4554, Lackland AFB, TX, 78236, USA.

Extramedullary plasmacytomas are rare neoplasms arising from proliferations of monoclonal plasma cells. In primary form, these malignancies occur without other sites of plasma cell disease. Secondary extramedullary plasmacytomas occur in association with multiple myeloma and may be discovered during initial intramedullary disease or may occur during multiple myeloma relapse. Read More

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http://dx.doi.org/10.1007/s00256-020-03514-9DOI Listing

Testicular plasmacytoma in a patient with relapsed multiple myeloma.

Int J Hematol 2020 Jun 8. Epub 2020 Jun 8.

First Propedeutic Department of Internal Medicine, AHEPA University Hospital, Medical School, Aristotle University of Thessaloniki, St. Kiriakidi 1, 54636, Thessaloníki, Greece.

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http://dx.doi.org/10.1007/s12185-020-02902-0DOI Listing

Primary extramedullary plasmacytoma of the eyelid conjunctiva - A case report and review of the literature.

Ann Med Surg (Lond) 2020 Jul 7;55:1-4. Epub 2020 May 7.

Ophthalmology Department, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Extramedullary plasmacytomas (EMPs) are uncommon plasma cell tumors that develop in soft tissue as isolated tumors without osseous involvement while secondary lesions are associated with systemic multiple myeloma (MM). Primary extramedullary lesions are most commonly found in upper respiratory tract, gastrointestinal tract and lymph nodes. They can be found either in patients with history of MM or preceding the manifestation of a systemic disease. Read More

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http://dx.doi.org/10.1016/j.amsu.2020.04.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229271PMC

First Reported Case of Extramedullary Plasmacytoma of the Appendix.

Gastroenterology Res 2020 Apr 22;13(2):85-87. Epub 2020 Apr 22.

Department of Pathology and Laboratory Medicine, University of California Irvine (UCI) Medical Center, Orange, CA 92868, USA.

An extramedullary plasmacytoma involving the gastrointestinal tract is extremely rare. We report an appendiceal extramedullary plasmacytoma in a 35-year-old man who presented to the emergency department because of upper abdominal pain. Computed tomography (CT) imaging revealed an incidental mass (3. Read More

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http://dx.doi.org/10.14740/gr1277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188365PMC

Extramedullary plasmacytoma of the nasal cavity and ethmoidal sinus in human immunodeficiency virus-positive patient.

J Cancer Res Ther 2020 Jan-Mar;16(1):157-160

Department of Otorhinolaryngology, Head and Neck Surgery, Jos University Teaching Hospital, Jos, Plateau State, Nigeria.

Extramedullary plasmacytoma (EMP) occurring in the nose and paranasal sinus regions are rare with a male preponderance in the fifth and seventh decades of life. We report a case of EMP of the nasal cavity and ethmoid sinus in a 28-year-old female with human immunodeficiency virus infection. Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_102_18DOI Listing

Extramedullary Plasmacytoma Involving the Heart: A Case Report and Focused Literature Review.

Cureus 2020 Mar 25;12(3):e7418. Epub 2020 Mar 25.

Internal Medicine, AdventHealth, Orlando, USA.

Cardiac tumors are extremely rare. Here, we report an unusual case of cardiac plasmacytoma that occurred 11 years after complete remission of the original multiple myeloma (MM). The tumor primarily manifested as a solitary extramedullary plasmacytoma (SEP) with extensive infiltration into the heart and large vessels. Read More

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http://dx.doi.org/10.7759/cureus.7418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182159PMC

Plasmacytoma in patients with multiple myeloma: morphology and immunohistochemistry.

BMC Cancer 2020 Apr 22;20(1):346. Epub 2020 Apr 22.

FSFI «National Research Center for Hematology», Moscow, Russian Federation.

Background: To study the histological structure and immunohistochemical (IHC) parameters of the plasmacytoma tumour substrate in patients with multiple myeloma (MM).

Methods: The study included 21 patients (10 men/11 women) aged 23 to 73 years old with newly diagnosed MM complicated by plasmacytoma. Bone plasmacytoma was diagnosed in 14 patients, and extramedullary plasmacytoma was diagnosed in 7 patients. Read More

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http://dx.doi.org/10.1186/s12885-020-06870-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178964PMC

Trabeculectomy in an unsuspected extramedullary iris-ciliary body plasmacytoma.

Eur J Ophthalmol 2020 Apr 21:1120672120920225. Epub 2020 Apr 21.

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Extramedullary plasmacytoma of the iris and ciliary body is extremely rare. We present a case which was misdiagnosed as granulomatous uveitis with neovascular glaucoma, and underwent a trabeculectomy with mitomycin-c along with iris biopsy. The post-operative period showed early bleb failure and catastrophic growth of the suspected mass. Read More

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http://dx.doi.org/10.1177/1120672120920225DOI Listing

Multiple myeloma presenting as plasmacytoma causing obstructive jaundice.

Proc (Bayl Univ Med Cent) 2020 Apr 27;33(2):266-267. Epub 2020 Feb 27.

Department of Gastroenterology, SUNY Upstate Medical UniversitySyracuseNew York.

Jaundice, weight loss, and anorexia are common symptoms that raise concern for pancreatic malignancy. Although the most common form of pancreatic malignancy is pancreatic adenocarcinoma, not all pancreatic malignancies are exocrine in origin. Pancreatic plasmacytomas are plasma cell tumors that can lead to similar presentations. Read More

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http://dx.doi.org/10.1080/08998280.2020.1722051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7155990PMC

Epstein-Barr virus-positive plasmacytoma in immunocompetent patients: a diagnostic dilemma.

Int J Clin Exp Pathol 2020 1;13(3):582-586. Epub 2020 Mar 1.

Department of Pathology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School Nanjing, China.

By literature review, plasmacytomas arising in immunocompetent patients are rarely associated with Epstein-Barr virus (EBV) infection. EBV-positive plasmacytoma can cause a diagnostic dilemma as it may morphologically and phenotypically overlap with a clinically aggressive plasmablastic lymphoma (PBL). We reported the clinicopathologic and immunophenotypic findings of four patients with EBV-positive plasmacytomas (three cases of extramedullary plasmacytomas, one case of solitary plasmacytoma of bone) with immunocompetent status. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137007PMC

Extramedullary nasal plasmacytoma arising after polyp excision and the role of the inflammation in tumor development: A case report.

Mol Clin Oncol 2020 May 26;12(5):451-455. Epub 2020 Feb 26.

Department of Otolaryngology, University of Perugia, I-65121 Perugia, Italy.

A correlation between inflammation and cancer has been identified in the case of nasal cancer, however a specific connection between nasal inflammation and extramedullary nasal plasmacytoma (ENP), to the best of our knowledge, has not yet been determined. The present case report describes a patient affected by ENP, in who the tumor arose in the same area, from which a nasal polyp was previously surgically removed, five months after the polyp excision. The patient underwent surgical endoscopic tumor asportation without being treated with radio-chemotherapy. Read More

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http://dx.doi.org/10.3892/mco.2020.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087468PMC

Orbital Plasmacytoma, An Uncommon Presentation of Advanced Multiple Myeloma.

Eur J Case Rep Intern Med 2020 31;7(3):001149. Epub 2020 Jan 31.

Intensive Care Unit, Coimbra Hospital and University Center and Faculty of Medicine of the University of Coimbra, Coimbra, Portugal.

Introduction: Extramedullary plasmacytomas are present in 13% of multiple myeloma (MM) patients. Less than 5% of MM cases are non-secretory. The orbital location is uncommon and a minority of orbital tumours are plasmacytomas. Read More

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http://dx.doi.org/10.12890/2020_001149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083190PMC
January 2020

Maximizing the Clinical Benefit of Radiotherapy in Solitary Plasmacytoma: An International Multicenter Analysis.

Cancers (Basel) 2020 Mar 13;12(3). Epub 2020 Mar 13.

Department of Radiation Oncology, University Hospital of Munster, Albert-Schweitzer-Campus 1, Building A1, 48149 Munster, Germany.

: Although local definitive radiotherapy (RT) is considered the standard of care for solitary plasmacytoma (SP), the optimal RT parameters for SP patients have not been defined. The aim of this retrospective study is to analyze the effectiveness of various RT doses, volumes, and techniques, as well as to define the relevant prognostic factors in SP. : Between 2000 and 2019, 84 patients, including 54 with solitary bone plasmacytoma (SBP) and 30 with extramedullary plasmacytoma (EMP), underwent RT at six institutions. Read More

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http://dx.doi.org/10.3390/cancers12030676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139814PMC

Spontaneous Regression of a Mandibular Plasmacytoma in a Juvenile Dog: A Case Report.

J Am Anim Hosp Assoc 2020 May/Jun;56(3):e56301. Epub 2020 Mar 17.

From Fitzpatrick Referrals Oncology and Soft Tissue, Guildford, United Kingdom (E.V.); Bridge Pathology Ltd., Bristol, United Kingdom (S.B.); and Fitzpatrick Referrals Oncology and Soft Tissue, Guildford, United Kingdom (L.F.).

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http://dx.doi.org/10.5326/JAAHA-MS-6932DOI Listing

Septal Nasal Extramedullary Plasmacytoma: A Rare Tumor in an Unusual Area.

Ear Nose Throat J 2020 Mar 15:145561320911735. Epub 2020 Mar 15.

AOU San Giovanni e Ruggi D'Aragona, University of Salerno, Italy.

We present an extreme rare case of extramedullary nasal plasmacitoma that arise from nasal septum. The mass surgically removed was analyzed by a pathologist who diagnosed an extramedullary nasal plasmacytoma. The patient did not present systemic involvement. Read More

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http://dx.doi.org/10.1177/0145561320911735DOI Listing
March 2020
0.881 Impact Factor

Retinal ischemia due to extramedullary plasmacytomas of the orbit.

J Clin Neurosci 2020 Feb 22;72:447-449. Epub 2020 Jan 22.

Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia; Clinical Haematology, Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, Victoria, Australia.

Visual disturbance is a common complaint in patients with multiple myeloma, both at diagnosis and later in their course, and has a broad differential. Here, we report a novel cause of visual disturbance, namely retinal ischemia due to extramedullary plasmacytomas of the orbit. A 69 year-old male patient with known multiple myeloma presented with reduced vision in his left eye. Read More

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http://dx.doi.org/10.1016/j.jocn.2020.01.052DOI Listing
February 2020

Extramedullary plasmacytoma of the eyelid.

J Fr Ophtalmol 2020 Feb 15;43(2):177-178. Epub 2020 Jan 15.

Department of Ophthalmology, Hospital Clinico-San-Carlos, Calle del Prof Martín Lagos s/n, 28040 Madrid, Spain.

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http://dx.doi.org/10.1016/j.jfo.2019.07.021DOI Listing
February 2020

[Solitary plasmacytoma of the lung treated with radiotherapy: case study and literature review].

Pan Afr Med J 2019 23;34:92. Epub 2019 Apr 23.

Service d'Oncologie Radiothérapie, Centre Hospitalo-Universitaire Mohammed VI, Avenue Ibn Sina, Marrakech, Maroc.

Isolated malignant extramedullary plasma cell proliferations known as plasmocytomas are rare. They usually occur in the head and the neck (80% of cases) and exceptionally elsewhere. We report the case of a 62-year old patient with solitary plasmacytoma of the lung initially mimicking primary lung cancer. Read More

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http://dx.doi.org/10.11604/pamj.2019.34.92.20089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945674PMC
January 2020

Clinical Features of Head and Neck Solitary Extramedullary Plasmacytoma in Taiwan.

In Vivo 2020 Jan-Feb;34(1):261-265

Department of Otorhinolaryngology, China Medical University Hospital, Taichung, Taiwan, R.O.C

Background/aim: Solitary extramedullary plasmacytoma (SEP) is a rare, malignant plasma-cell tumor, which mainly occurs in the head and neck regions. Globally the disease has been rarely happening up to 2019, with only about ten papers focused on SEP cases reported in English. Thus, a literature collectively reviewing the characteristics of the patients would be valuable. Read More

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http://dx.doi.org/10.21873/invivo.11769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984109PMC

Extramedullary plasmacytoma of the kidney in an HIV-positive patient: A case report.

Medicine (Baltimore) 2019 Dec;98(52):e18422

Department of Urology.

Rationale: Extramedullary plasmacytoma (EMP) is a very rare malignant neoplasm arising from clonal proliferation of atypical plasma cells. Most EMPs involve mucosal lymphoid tissue, particularly in the nasopharyngeal area, respiratory tract, and head and neck region. Such neoplasms of the kidney in patients with a human immunodeficiency virus (HIV) infection are extremely rare. Read More

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http://dx.doi.org/10.1097/MD.0000000000018422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946407PMC
December 2019

Rare multifocal manifestation of solitary extramedullary plasmacytomas.

BMJ Case Rep 2019 Dec 15;12(12). Epub 2019 Dec 15.

Radiology, King's College Hospital NHS Foundation Trust, London, UK.

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http://dx.doi.org/10.1136/bcr-2019-232273DOI Listing
December 2019

Evaluation of the Survival Outcomes of Multiple Myeloma Patients According to their Plasmacytoma Presentation at Diagnosis

Turk J Haematol 2019 12 13. Epub 2019 Dec 13.

Hacettepe University Faculty of Medicine, Department of Hematology, Ankara, Turkey

Objective: Multiple myeloma (MM) associated with extramedullary (EM) plasmacytoma has a poor therapeutic response and poor outcomes when treated with conventional chemotherapy. EM plasmacytoma is divided into two groups: the first group comprised tumors that are extending directly from osteolytic bone lesions (EM-B, bone-related), while the second results from plasmacytoma infiltration into soft tissues, with no relationship to the bone (EM-S, soft tissue-related). This study aimed to compare the general characteristics and survival outcomes of transplant eligible MM patients who had EM-S or EM-B and MM patients who did not have plasmacytoma at the time of diagnosis. Read More

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http://dx.doi.org/10.4274/tjh.galenos.2019.2019.0061DOI Listing
December 2019
0.340 Impact Factor

Imaging features of extramedullary plasmacytoma.

J Med Imaging Radiat Oncol 2020 Feb 29;64(1):44-51. Epub 2019 Nov 29.

Department of Radiology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.

Extramedullary plasmacytomas are rare and can occur at any site. The imaging results are often nonspecific. This report highlights the radiographic, sonographic and cross-sectional imaging features of extramedullary plasmacytomas. Read More

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http://dx.doi.org/10.1111/1754-9485.12975DOI Listing
February 2020

An unusual case of solitary spinal intradural plasmacytoma: The unforeseen challenge.

J Craniovertebr Junction Spine 2019 Jul-Sep;10(3):192-196

Department of Neurosurgery, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Localized proliferation of atypical plasma cells, either at bony or extramedullary, forms a rare subset of multiple myeloma (MM) disorders. The patients usually present with intractable pain and pathological fractures and respond well to radiotherapy. The clinical presentation is variable and radiologically is nonspecific. Read More

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http://dx.doi.org/10.4103/jcvjs.JCVJS_51_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868541PMC
November 2019

Solitary Extramedullary Plasmacytoma of the Sphenoid Sinus: A Case Report.

Indian J Otolaryngol Head Neck Surg 2019 Nov 21;71(Suppl 3):1692-1694. Epub 2015 Dec 21.

Department of Otorhinolaryngology, Hospital Queen Elizabeth, Kota Kinabalu, Sabah Malaysia.

Solitary extramedullary plasmacytomas are rare, discrete mass of neoplastic monoclonal plasma cells in the soft tissue with no evidence of multiple myeloma. They constitute 3 % of all plasma cell tumors and less than 1 % of head and neck malignancies. A 43 year old lady presented to our clinic with complains of diplopia and headache for 4 weeks. Read More

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http://dx.doi.org/10.1007/s12070-015-0945-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848286PMC
November 2019

Unexpected response of extramedullary plasmacytoma in patients with lung cancer who received nivolumab.

Ann Hematol 2019 Dec 16;98(12):2851-2852. Epub 2019 Nov 16.

Department of Respiratory Medicine, Saitama Medical University International Medical Center, 1397-1, Yamane, Hidaka, 350-1298, Japan.

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http://dx.doi.org/10.1007/s00277-019-03832-6DOI Listing
December 2019

Hematologic malignancies of the gastrointestinal luminal tract.

Abdom Radiol (NY) 2019 Nov 9. Epub 2019 Nov 9.

Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.

Hematologic malignancies include several lymphoproliferative and myeloproliferative disorders, many of which are frequently encountered in current health care settings. These malignancies frequently affect the gastrointestinal (GI) tract, either by secondary extranodal or extramedullary extension to the GI tract, or as a primary process arising in the GI tract. In fact, the GI tract may represent the most common extranodal site of involvement in many of them, such as lymphoma. Read More

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http://dx.doi.org/10.1007/s00261-019-02278-8DOI Listing
November 2019

[Rare cause of gastrointestinal bleeding].

Dtsch Med Wochenschr 2019 10 21;144(21):1505-1508. Epub 2019 Oct 21.

Abteilung für Diagnostische und Interventionelle Radiologie und Neuroradiologie, Klinikum Augsburg.

Histology And Clinical Findings: We report on a 66-year-old-patient with plasmocytoma, who presented with melena since 3 days, dyspnea and dizzyness.

Investigation And Diagnosis: Because of the laboratory and clinical examination the suspected diagnosis was an active gastrointestinal bleeding. The performed gastroduodenoscopy and sigmoidoscopy could not verify an active bleeding. Read More

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http://dx.doi.org/10.1055/a-0969-7171DOI Listing
October 2019

Primary Plasmacytoma in the Cerebellum: A Case Report and Literature Review.

World Neurosurg 2020 Feb 16;134:10-13. Epub 2019 Oct 16.

Department of Neurosurgery, Iwate Medical University, Morioka, Japan.

Background: Most plasmacytomas arise in the bone marrow (intramedullary), as part of multiple myeloma (MM). In contrast, extramedullary plasmacytoma without MM is rare, and plasmacytoma primarily occurring in the brain parenchyma is extremely rare. Clinical behaviors of primary plasmacytoma in the brain have remained unclear. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.10.036DOI Listing
February 2020

Laparoscopic partial resection of retroperitoneal extramedullary plasmacytoma.

Cir Esp 2020 May 11;98(5):299-301. Epub 2019 Oct 11.

Allgemein Öffentliches Ladislaus Betthyany Strattmann Krankenhaus Kittsee, Kittsee, Austria; Hospital Universitario de Guadalajara, Guadalajara, España, Universidad de Alcalá.

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http://dx.doi.org/10.1016/j.ciresp.2019.08.003DOI Listing
May 2020
1 Read

Successful treatment with pomalidomide and intrathecal injections for central nervous system plasmacytoma in a patient under haemodialysis.

J Clin Pharm Ther 2020 Feb 10;45(1):221-225. Epub 2019 Oct 10.

Division of Hematology, Japanese Red Cross Society Wakayama Medical Center, Wakayama, Japan.

What Is Known And Objectives: The involvement of the central nervous system (CNS) in multiple myeloma (MM) is uncommon and has an extremely poor prognosis, and optimal treatment strategies for the CNS MM patients have not yet been established.

Case Summary: A 71-year-old MM patient with severe renal impairment exhibited extramedullary relapse in the CNS and progression while being treated with lenalidomide and dexamethasone. However, she achieved very good partial remission after a treatment with pomalidomide, cyclophosphamide and dexamethasone (PCD) in combination with intrathecal chemotherapy. Read More

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http://dx.doi.org/10.1111/jcpt.13054DOI Listing
February 2020
1 Read

Fluorine-18-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in a Giant Left Pectoral Muscle Plasmacytoma and Multiple Myeloma Case.

Indian J Nucl Med 2019 Oct-Dec;34(4):341-343

Department of Nuclear Medicine, Valdecilla University Hospital, Molecular Imaging Group (IDIVAL), University of Cantabria, Santander, Spain.

Extramedullary plasmacytoma is an unusual manifestation in multiple myeloma (MM). It can present as a solitary bone lesion and/or soft-tissue mass. Plasmacytoma can be presented at any location, but it is more common in the head and neck, usually without systemic involvement. Read More

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http://dx.doi.org/10.4103/ijnm.IJNM_83_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771214PMC
October 2019
1 Read

Single-cell RNA sequencing reveals chemokine self-feeding of myeloma cells promotes extramedullary metastasis.

FEBS Lett 2020 Feb 17;594(3):452-465. Epub 2019 Oct 17.

Department of Hematology, Biodynamic Optical Imaging Center (BIOPIC) and Lymphoma Research Center, Third Hospital, Peking University, Beijing, China.

In this study, we aimed to determine the mechanisms underlying the initial extramedullary translocation of myeloma cells from bone marrow into peripheral blood. We found that clonal circulating plasma cells (cPCs) are more frequently detected by flow cytometry in extramedullary plasmacytoma (EMP) patients and worsen their prognosis. It is technically much easier to collect single cPCs using FACS than it is to perform EMP biopsy. Read More

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http://dx.doi.org/10.1002/1873-3468.13623DOI Listing
February 2020
2 Reads

Mandibular involvement of plasmacytoma - Uncommon case report of rare entity.

Ann Med Surg (Lond) 2019 Sep 13;45:95-97. Epub 2019 Jul 13.

Institute of Pathology, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje, Macedonia.

Solitary plasmacytoma (SP) is an early-stage plasma cell malignancy that is in between monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (MM) along the spectrum of plasma cell disorders. SPs can be divided into 2 groups according to location: solitary bone plasmacytoma (SBP) - these occur most commonly in the vertebrae and secondarily in long bones, and extramedullary plasmacytoma (EMP) - these encompass all nonosseus SPs. The etiology is still unknown, and they generally display a destructive course with preponderance of males. Read More

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http://dx.doi.org/10.1016/j.amsu.2019.07.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698279PMC
September 2019
2 Reads

Pancreatic tumor in type 1 autoimmune pancreatitis: a diagnostic challenge.

BMC Cancer 2019 Aug 16;19(1):814. Epub 2019 Aug 16.

Department of Radiology, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan 2nd Road, Guangzhou, Guangdong, 510080, People's Republic of China.

Background: The co-occurrence of type 1 autoimmune pancreatitis (AIP) and pancreatic tumor (PaT) has been previously reported. Pure AIP cases have favorable prognosis and are primarily treated with steroids, while AIP cases with PaT are associated with poor prognosis where the primary management is pancreatic resection. However, it's a challenge to timely identify the concurrent PaT in AIP because of their similar clinical and radiological manifestations. Read More

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http://dx.doi.org/10.1186/s12885-019-6027-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698045PMC
August 2019
1 Read

Clinicopathological spectrum of solitary Plasmacytoma: a single center experience from coastal India.

BMC Cancer 2019 Aug 14;19(1):801. Epub 2019 Aug 14.

Medical Oncologist, Mangalore Institute of Oncology, Mangalore, Karnataka, India.

Background: Plasma cell disorders are a rare group of hematological malignancies that accounts for 10% of all hematological neoplasms. Solitary plasmacytomas are rarer entities accounting for less than 5% of all the plasma cell dyscrasias. They encompass three subtypes - Solitary Plasmacytoma of Bone (SPB) and Solitary Extramedullary Plasmacytoma (SEP) and multiple solitary plasmacytomas (MSP). Read More

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http://dx.doi.org/10.1186/s12885-019-5976-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693151PMC
August 2019
4 Reads

Light chain myeloma: A brief report from India.

Indian J Pathol Microbiol 2019 Jul-Sep;62(3):441-444

Department of Hemato-Oncology, Rajiv Gandhi Cancer Institute and Research Center, New Delhi, India.

Light chain myeloma (LCM) has a reported worldwide incidence of approximately 15%-20% among all multiple myeloma (MM) patients. Few western studies have shown strong correlation of LCM with anemia, higher International Staging System scores, proclivity to renal failure, elevated lactate dehydrogenase levels, raised serum-free light chain ratio, higher frequency of extramedullary plasmacytomas, and poorer overall survival, attributable probably to lack of differentiation and skeletal destruction. The primary aim of this retrospective observational study was to define the clinical and hematological characteristics as well as prognostic outcome of Indian LCM patients in comparison with the IgG and IgA subtypes. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_385_18DOI Listing
December 2019
8 Reads
0.642 Impact Factor

Long-term clinical outcomes in a cohort of patients with solitary plasmacytoma treated in the modern era.

PLoS One 2019 23;14(7):e0219857. Epub 2019 Jul 23.

Oxford University Hospital NHS Foundation Trust, Oxford, United Kingdom.

Background: The risk of recurrence of solitary plasmacytoma (SP)/progression to MM is well established, but patient, imaging and treatment factors influencing risk of progression require further evaluation.

Methods: This is a retrospective analysis of 66 SP patients (23 UK, 43 Brazil) diagnosed 1989-2016. Patient baseline characteristics were recorded. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0219857PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650037PMC
February 2020
1 Read

Hematogenous extramedullary relapse in multiple myeloma - a multicenter retrospective study in 127 patients.

Am J Hematol 2019 10 13;94(10):1132-1140. Epub 2019 Aug 13.

Department of Hematology, Jagiellonian University Medical College, Cracow, Poland.

The current study assesses the characteristics and outcomes of multiple myeloma (MM) patients, treated with novel agents for hematogenous extramedullary (HEMM) relapse. Consecutive patients diagnosed with HEMM between 2010-2018 were included. Patients' characteristics at diagnosis and at HEMM presentation, response to treatment, survival and factors predicting survival were recorded and analyzed. Read More

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http://dx.doi.org/10.1002/ajh.25579DOI Listing
October 2019
3 Reads
3.798 Impact Factor

Diplopia and proptosis due to isolated lateral rectus plasmacytoma in a patient with multiple myeloma.

BMJ Case Rep 2019 Jul 8;12(7). Epub 2019 Jul 8.

Ophthalmology, St. John's Episcopal Hospital, Far Rockaway, New York, USA.

Orbital involvement of multiple myeloma (MM) is uncommon, with most of those reported cases occurring at the time of initial diagnosis of MM. We present a case of an extramedullary plasmacytoma involving only the right lateral rectus of a patient who had been in disease remission. The patient presented with new-onset diplopia and an abduction deficit of the right eye, with mild proptosis. Read More

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http://dx.doi.org/10.1136/bcr-2018-229178DOI Listing
July 2019
8 Reads

Myeloma of Laryngeal Cartilage: Literature Review and Case Study.

Ear Nose Throat J 2019 Jul 8:145561319861379. Epub 2019 Jul 8.

2 Department of Medical Imaging, Gold Coast University Hospital, Southport, Queensland, Australia.

Background: Myeloma of laryngeal cartilage (MLC) is a rare plasma cell neoplasm which has not been well characterized. However, it is an important differential diagnosis of laryngeal cartilage mass as it can indicate the presence of underlying systemic hematological diseases, such as multiple myeloma (MM), that is associated with poor prognosis. This article is the first of its kind and aims to educate clinicians on future diagnosis and management of similar cases. Read More

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http://dx.doi.org/10.1177/0145561319861379DOI Listing
July 2019
3 Reads

A real world multicenter retrospective study on extramedullary disease from Balkan Myeloma Study Group and Barcelona University: analysis of parameters that improve outcome.

Haematologica 2020 Jan 5;105(1):201-208. Epub 2019 Jul 5.

Department of Clinical Therapeutics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece.

Here, we report the outcome of 226 myeloma patients presenting with extramedullary plasmacytoma or paraosseous involvement in a retrospective study conducted in 19 centers from 11 countries. Extramedullary disease was detected at diagnosis or relapse between January 2010 and November 2017. Extramedullary plasmacytoma and paraosseous involvement were observed in 130 patients at diagnosis (92 of 38) and in 96 at relapse (84 of 12). Read More

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http://dx.doi.org/10.3324/haematol.2019.219295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939516PMC
January 2020
5 Reads

Extramedullary Plasmacytoma Involving the Trachea: A Case Report and Literature Review.

J Emerg Med 2019 Sep 29;57(3):e65-e67. Epub 2019 Jun 29.

Department of Emergency Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: Extramedullary plasmacytoma is an uncommon type of plasma cell neoplasm that occurs outside of the bone marrow. Very rarely, extramedullary plasmacytomas can involve the trachea, causing significant respiratory distress.

Case Report: We describe a patient with a history of multiple myeloma who presented with voice hoarseness and dyspnea and was found to have airway obstruction due to an extramedullary plasmacytoma near the larynx. Read More

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http://dx.doi.org/10.1016/j.jemermed.2019.05.032DOI Listing
September 2019
6 Reads

Late Onset Graft Plasmacytoma-Like PTLD Presenting as Acute Hyperglycemia in a Kidney-Pancreas Transplant Recipient.

Case Rep Nephrol 2019 19;2019:2818074. Epub 2019 May 19.

Department of Nephrology and Renal Transplant, Hospital Clínic, Barcelona, Spain.

Allograft infiltration has been described in up to 20% of all patients with posttransplant lymphoproliferative disorder (PTLD), most representing EBV-positive B-cell lymphomas. Plasma cells are often observed in humoral rejection biopsies, but graft infiltration by plasmacytoma-like PTLD is rare. We report the case of a 54-year-old simultaneous pancreas-kidney transplant recipient (immunosuppression: OKT3, methylprednisolone, cyclosporine, and azathioprine), diagnosed with an IgG-kappa monoclonal gammopathy of undetermined significance eighteen years after transplant. Read More

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https://www.hindawi.com/journals/crin/2019/2818074/
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http://dx.doi.org/10.1155/2019/2818074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545763PMC
May 2019
6 Reads

A rare solitary duodenum plasmacytoma.

Rev Esp Enferm Dig 2019 Jul;111(7):563

Department of Gastroenterology, Shenzhen People's Hospital, China.

Multiple myeloma (MM) is typical of uncontrolled and clonal growth of malignant plasma cells in the bone marrow, then leads to primary symptoms related to bone narrow infiltration and destruction bone lesion. The term of extramedullary plasmacytoma is used to defined malignant plasma cells are found out of the bone marrow. In this study, we reported a rare duodenum plasmacytoma accompanied by gastrointestinal symptoms. Read More

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http://dx.doi.org/10.17235/reed.2019.6090/2018DOI Listing
July 2019
11 Reads

Multiple myeloma presenting as dural plasmacytoma.

Radiol Case Rep 2019 Aug 8;14(8):1007-1013. Epub 2019 Jun 8.

Department of Radiology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71103, USA.

The finding of intracranial, extramedullary plasmacytoma is rare in multiple myeloma, especially with dural involvement. Meningioma remains the most common intracranial extra-axial mass. We report a case of a 39-year-old male who presented with intracranial, extra-axial mass found later to be dural plasmacytoma and additional multiple lesions on skeletal survey, leading to a diagnosis of multiple myeloma. Read More

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http://dx.doi.org/10.1016/j.radcr.2019.05.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556834PMC
August 2019
5 Reads

Primary extramedullary plasmacytoma with diffuse lymph node involvement: a case report and review of the literature.

J Med Case Rep 2019 May 22;13(1):153. Epub 2019 May 22.

New York University School of Medicine and New York University Perlmutter Cancer Center, 240 East 38th street, 19Floor, New York, NY, 10016, USA.

Background: Primary plasmacytomas are localized proliferations of clonal plasma cells occurring in the absence of a systemic plasma cell dyscrasia such as multiple myeloma. Primary plasmacytomas most commonly manifest as solitary lesions of the bone or of the upper aerodigestive tract. Presentation in a lymph node is very uncommon and can often be initially mistaken for lymphoma. Read More

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http://dx.doi.org/10.1186/s13256-019-2087-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530079PMC
May 2019
7 Reads

Solitary plasmacytoma of mandible: A rare entity.

J Oral Maxillofac Pathol 2019 Jan-Apr;23(1):136-139

Department of Oral and Maxillofacial Pathology, Mamata Dental College and Hospital, Khammam, Telangana, India.

Plasmacytoma is a discrete, unifocal, monoclonal neoplastic proliferation of the plasma cells. It may present as one of the three distinct clinical entities: multiple myeloma (MM), solitary plasmacytoma of bone and extramedullary plasmacytoma. Solitary bone plasmacytoma accounts for 3% of all plasma cell neoplasms with approximately 50% of the cases transforming into MM. Read More

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http://dx.doi.org/10.4103/jomfp.JOMFP_175_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503795PMC
May 2019
5 Reads

[Secondary extramedullary bilateral orbital plasmacytoma in a 65-year-old man].

Authors:
T Rodriguez V Bon

J Fr Ophtalmol 2019 06 14;42(6):e267-e269. Epub 2019 May 14.

Service d'ophtalmologie CHRU Rennes, Pontchaillou, 2, rue Henri-Le-Guilloux, 35000 Rennes, France.

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http://dx.doi.org/10.1016/j.jfo.2018.11.016DOI Listing
June 2019
3 Reads