1,725 results match your criteria Plasmacytoma Extramedullary

Intracerebral Plasmacytoma in a Patient with HIV-1 Infection and SARS-CoV-2 Superinfection.

Brain Sci 2022 May 30;12(6). Epub 2022 May 30.

Hematology and Chemotherapy Clinic, Riga East Clinical University Hospital, Hipokrāta Street 2, LV-1038 Rīga, Latvia.

We present a rare case of intracranial solitary plasmacytoma arising in brain parenchyma in the basal nuclei. Clinical management and autopsy results of the case are described. Background: Intracranial plasmacytomas arising from brain parenchyma are extremely rare, and data from the literature are limited. Read More

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Intrathyroidal Plasmacytoma with Pleomorphic Multilobated Bizarre Cells: A Rare Primary Clinicopathological Presentation Mimicking Anaplastic Carcinoma of Thyroid.

Head Neck Pathol 2022 Jun 14. Epub 2022 Jun 14.

Laboratory Services & Molecular Diagnostics, Rajiv Gandhi Cancer Institute & Research Centre, Delhi, 110085, India.

Background: Plasmacytoma involving thyroid gland is infrequent and can present as either primary extramedullary plasmacytoma or secondary to multiple myeloma.

Methods And Results: We present a case of 71 years old male who complained of a huge anterior neck swelling accompanied by dysphagia and dyspnoea. Fine needle aspiration cytology was suggestive of anaplastic carcinoma of thyroid (ATC), however, the subsequent histomorphology supported by immunohistochemistry (IHC) astoundingly favoured the diagnosis of plasmacytoma. Read More

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PVR (CD155) Expression as a Potential Prognostic Marker in Multiple Myeloma.

Biomedicines 2022 May 10;10(5). Epub 2022 May 10.

Department of Internal Medicine, Korea University College of Medicine, Seoul 02841, Korea.

Poliovirus receptor (PVR, CD155) is upregulated during tumor progression, and PVR expression is associated with poor prognosis in cancer patients; however, prognostic implications for PVR in multiple myeloma (MM) have not been investigated. PVR plays an immunomodulatory role by interacting with CD226, CD96, and TIGIT. TIGIT is a checkpoint inhibitory receptor that can limit adaptive and innate immunity, and it binds to PVR with the highest affinity. Read More

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Real-World Evidence of Daratumumab Monotherapy in Relapsed/Refractory Multiple Myeloma Patients and Efficacy on Soft-Tissue Plasmacytomas.

Clin Lymphoma Myeloma Leuk 2022 Apr 17. Epub 2022 Apr 17.

Hematology Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain. Electronic address:

Introduction: Daratumumab is an anti-CD38 agent that was first investigated as single agent in GEN501 and SIRIUS trials in patients with advanced multiple myeloma (MM). Overall response rate (ORR) was 30% with positive impact on progression-free survival (PFS). However, there is a lack of information regarding plasmacytoma response. Read More

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Extramedullary plasmacytoma: Tumor occurrence and therapeutic concepts-A follow-up.

Cancer Med 2022 May 16. Epub 2022 May 16.

Department of Otorhinolaryngology, Head & Neck Surgery, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.

Background: Extramedullary plasmacytoma (EMP) is a solitary tumor consisting of neoplastic plasma cells, with very little to no bone marrow involvement. EMPs are usually located in the head and neck region, but can also occur along the digestive tract, in lungs, or extremities.

Methods: Following our publication on EMP, which appeared in 1999 (Cancer 85:2305-14), we conducted a literature search for EMP-related reports published between 1999 and 2021. Read More

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Multiple myeloma with presentation in the oral cavity.

J Oral Maxillofac Pathol 2022 Jan-Mar;26(1):104-107. Epub 2022 Mar 31.

Department of Oral and Maxillofacial Pathology, D Y Patil University School of Dentistry, Navi Mumbai, Maharashtra, India.

Plasma cell neoplasms may present in the bone as monoclonal gammopathy of undetermined significance, solitary plasmacytoma of bone, multifocal plasma cell neoplasm of bones known as multiple myeloma (MM) and in soft tissues as extramedullary plasmacytoma. MM is a malignant disease of atypical plasma cells characterized by their multifocal proliferation and production of monoclonal immunoglobulins. Often, the initial clinical feature of this disease is subtle and requires trained primary health-care providers to identify this illness and put together a suitable treatment plan. Read More

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A Rare Case of Solitary Plasmacytoma Arising From the Sternum.

Cureus 2022 Apr 4;14(4):e23819. Epub 2022 Apr 4.

Hematology and Oncology, Saint Michael's Medical Center, Newark, USA.

Solitary plasmacytoma (SP) is characterized by an accumulation of neoplastic monoclonal plasma cells in a localized fashion, without evidence of multiple myeloma. It makes up <5% of all plasma cell neoplasms and is typically found in regions like the pelvis, ribs, vertebra, and spine. SP is classified into extramedullary plasmacytoma (EMP), which primarily affects soft tissues, and solitary bone plasmacytoma (SBP), which primarily affects the pelvis, ribs, vertebrae, and spine. Read More

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Solitary Primary Intracranial Extramedullary Plasmacytoma With Lymph Node Metastasis.

Cureus 2022 Apr 2;14(4):e23767. Epub 2022 Apr 2.

Hematology and Medical Oncology, Cooperman Barnabas Medical Center, Livingston, USA.

Multiple myeloma is a neoplastic disease of plasma cells. Plasma cell disorders can present as a single lesion (solitary plasmacytoma) or as multiple lesions (multiple myeloma). Solitary plasmacytomas can occur in bone (plasmacytoma of bone) or in soft tissues (extramedullary plasmacytoma), and both can serve as a precursor lesion to multiple myeloma. Read More

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Extramedullary plasmacytoma of the sphenoid sinus presenting with visual loss: A case report.

Clin Case Rep 2022 Apr 25;10(4):e05758. Epub 2022 Apr 25.

Otolaryngology Department Shahid Beheshti University of Medical Sciences Tehran Iran.

A rare case of sphenoid plasmacytoma in a 62-year-old woman who was presented with a frozen eye is reported. It was histopathologically confirmed based on transsphenoidal biopsy. Moreover, initial evaluation ruled out systemic dissemination of the disease and solitary plasmacytoma was diagnosed. Read More

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Extramedullary plasmacytoma with colonic involvement: experience of two cases in a tertiary hospital.

Rev Esp Enferm Dig 2022 Apr 26. Epub 2022 Apr 26.

Aparato Digestivo, Hospital Clínico Universitario Virgen de la Arrixaca, España.

A 71-year-old woman diagnosed with type II diabetes mellitus with severe iron deficiency anemia and positive fecal occult blood. Colonoscopy was performed, showing a soft mass (figure A) in the ascending colon, with biopsies compatible with plasmacytoma and restriction for Kappa light chains (figure C and D). After bone marrow aspiration, associated IgG multiple myeloma was detected, so chemotherapy with VMP (Bortezomib, Melphalan and Prednisone) was started. Read More

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Relapse with plasmacytoma after upfront autologous stem cell transplantation in multiple myeloma.

Ann Hematol 2022 Jun 21;101(6):1217-1226. Epub 2022 Apr 21.

BioMedical Sciences Graduate Program, Chonnam National University, Gwangju, Republic of Korea.

Plasmacytoma has been reported to be associated with a poor prognosis in patients with multiple myeloma (MM). In this study, we evaluated the incidence of relapse with plasmacytoma and survival outcomes after upfront autologous stem cell transplantation (ASCT). This study retrospectively analyzed the data of 303 patients with MM who underwent upfront ASCT between April 2000 and April 2018 at eight institutes in the Republic of Korea. Read More

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Analysis of the Treatment and Survival of Sinonasal Extramedullary Plasmacytoma.

Am J Rhinol Allergy 2022 Apr 19:19458924221092529. Epub 2022 Apr 19.

Department of Otolaryngology - Head and Neck Surgery, 12286Rutgers New Jersey Medical School, Newark, New Jersey, USA.

Background: While extramedullary plasmacytomas are infrequently encountered plasma cell malignancies, most cases occur in the head and neck, with a predilection for the sinonasal cavity. Due to the rarity of this disease, the majority of studies on sinonasal extramedullary plasmacytoma (SN-EMP) are case reports or small retrospective case series.

Objective: To investigate the impact of patient, disease, and treatment factors on the survival of patients with SN-EMP. Read More

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Comparison of clinical features of multiple myeloma with paraosseous and extraosseous plasmacytoma in the era of novel drugs: a systemic review and meta-analysis.

Expert Rev Hematol 2022 04 12;15(4):369-374. Epub 2022 Apr 12.

Hematology Department of the Affiliated Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu Province, China.

Background: Extramedullary myeloma has a more aggressive clinical course and inferior prognosis. Two types of extramedullary myeloma, paraosseous (PO) and extraosseous (EO), differ significantly in pathogenesis, clinical features, and outcomes, but there have been limited studies comparing them based on large patient cohorts.

Methods: Relevant studies published before June 2021 were searched in MEDLINE, Embase, and Cochrane databases. Read More

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[Primary extramedullary plasma cell tumor of the right kidney: report of a case].

Zhonghua Bing Li Xue Za Zhi 2022 Apr;51(4):360-362

Department of Pathology, the 940th Hospital of Joint Logistic Support Force of Chinese People's Liberation Army, Lanzhou 730000, China.

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Recurrent extramedullary plasmacytomas without multiple myeloma: A case report with review of the literature.

Cancer Treat Res Commun 2022 25;31:100550. Epub 2022 Mar 25.

Department of Medical Oncology, Amrita Institute of Medical Sciences and Research Centre P.O.AIMS Ponekkara, Kochi-682041, Kerala, India. Electronic address:

Background: Extramedullary plasmacytoma (EMP) is an uncommon presentation and usually occurs in conjunction with multiple myeloma (MM). An EMP without developing MM at any point is an extremely rare presentation, and only seven such cases have been reported in the literature to date.

Presentation Of Case: We present a case of EMP, who presented with multiple recurrent lesions in rare sites like nasal cavity, testis and skin without the involvement of bone marrow at any point of disease course. Read More

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Hidden in the Eyes-Recurrence of Systemic Hemopathies Reportedly "In Remission": Six Cases and Review of Literature.

Medicina (Kaunas) 2022 Mar 21;58(3). Epub 2022 Mar 21.

Centre Hospitalier National des Quinze-Vingts, CIC 1423, DHU Sight Restore, 28 rue de Charenton, Sorbonne-Universités, Université Pierre et Marie Curie (UPMC), 75012 Paris, France.

: Secondary ocular localizations of hematological malignancies are blinding conditions with a poor prognosis, and often result in a delay in the diagnosis. : We describe a series of rare cases of ocular involvement in six patients with hematological malignancies, reportedly in remission, who presented secondary ocular localizations, challenging to diagnose. Two patients had an acute lymphoblastic leukemia (ALL) and developed either a posterior scleritis or a pseudo-panuveitis with ciliary process infiltration. Read More

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Extramedullary disease in multiple myeloma: a systematic literature review.

Blood Cancer J 2022 03 21;12(3):45. Epub 2022 Mar 21.

Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

Extramedullary involvement (or extramedullary disease, EMD) represents an aggressive form of multiple myeloma (MM), characterized by the ability of a clone and/or subclone to thrive and grow independent of the bone marrow microenvironment. Several different definitions of EMD have been used in the published literature. We advocate that true EMD is restricted to soft-tissue plasmacytomas that arise due to hematogenous spread and have no contact with bony structures. Read More

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An Exceptional Case of Diplopia and Ptosis: Extramedullary Plasmacytoma of the Clivus With Multiple Myeloma.

Cureus 2022 Mar 16;14(3):e23219. Epub 2022 Mar 16.

Internal Medicine, State University of New York Downstate Health Sciences University, New York, USA.

Intracranial plasmacytoma is an exceedingly rare presentation of plasma cell neoplasms. Usually presenting late in the course of the disease, progression from the presentation can be abrupt. Hence, a low threshold to biopsy the lesion should be maintained during diagnostic evaluation. Read More

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Extramedullary Plasmacytoma: Hepatic Lesions and Enlarged Lymph Nodes With Intense 18F-FDG Uptake Mimicking Metastases.

Clin Nucl Med 2022 May;47(5):422-424

From the PET/CT Center, Department of Nuclear Medicine, Affiliated Hospital of Qingdao University, Qingdao, China.

Abstract: A 66-year-old woman having intermittent abdominal distention for 2 months was referred to our hospital. An enhanced abdominal CT scan showed multiple hepatic lesions, suspected of metastases. An 18F-FDG PET/CT scan, which was performed to seek primary tumor, showed multiple lesions with intense 18F-FDG uptake in the liver and lymph nodes located in cardiophrenic angle, abdominal cavity, and retroperitoneal space. Read More

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Extramedullary Plasmacytoma of the Sinonasal Cavity: Magnetic Resonance Imaging Characteristics With Readout-Segmented Diffusion-Weighted Imaging and Dual-Energy Computed Tomography Features.

J Comput Assist Tomogr 2022 Mar-Apr 01;46(2):264-268

From the Department of Radiology, Eye & ENT Hospital of Fudan University, Shanghai Medical School, Fudan University.

Purpose: To determine magnetic resonance imaging (MRI) with readout-segmented diffusion-weighted imaging (RESOLVE-DWI) and dual-energy computed tomography (DECT) features of sinonasal extramedullary plasmacytoma (SN-EMP).

Methods: The MRI and/or DECT of 10 patients with SN-EMP confirmed by pathology were retrospectively reviewed. Apparent diffusion coefficient (ADC) values of RESOLVE-DWI were analyzed in 9 patients. Read More

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Walking the Risk-Benefit Tight Rope: A Case of Post Fine Needle Aspiration Haemorrhage in Extramedullary Plasmacytoma.

Curr Med Imaging 2022 Mar 8. Epub 2022 Mar 8.

Department of Medical Oncology, BRA IRCH, All India Institute of Medical Sciences, New Delhi.

Background: Primary extramedullary plasmacytomas (EMP) are rare, however secondary forms may be seen in ~10-15% patients with systemic multiple myeloma (MM). The diagnosis of EMP is based on demonstration of monoclonal plasma cells in the lesion, which requires tissue sampling.

Case Presentation: We present a case of a 38 year old female with MM, who underwent diagnostic US at our institute. Read More

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Case Report: Plasmacytoma of External Urethral Meatus.

Front Endocrinol (Lausanne) 2022 16;13:783855. Epub 2022 Feb 16.

Department of Urology, The Third Xiangya Hospital, Central South University, Changsha, China.

Rationale: Extramedullary plasmacytoma (EMP) can occur in various parts of the body. It is generally accepted that the highest site of occurrence is the head and neck region (80% to 90%), followed by the gastrointestinal tract and the skin. It is worth mentioning that the site of disease, in this case, was the urethral meatus, which is extremely rare in clinical practice. Read More

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[Clinical analysis of 10 cases with extramedullary plasmacytoma of the head and neck].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2022 Feb;57(2):197-200

Department of Head Neck and Thyroid Surgery, Henan Tumor Hospital, Zhengzhou 450008, China.

To explore the clinical characteristics, treatment methods and outcomes of extramedullary plasmacytoma of the head and neck. A retrospective analysis was conducted on 10 cases with extramedullary plasmacytoma of the head and neck who were admitted to Henan Tumor Hospital from January 2005 to January 2020. Among the 10 patients, 6 were male and 4 were female. Read More

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February 2022

Modern radiographic imaging in multiple myeloma, what is the minimum requirement?

Semin Oncol 2022 02 20;49(1):86-93. Epub 2022 Jan 20.

Molecular Imaging Branch. National Cancer Institute, NIH, Bethesda, MD, USA.

Imaging innovations offer useful techniques applicable to many oncology specialties. Treatment advances in the field of multiple myeloma (MM) have increased the need for accurate diagnosis, particularly in the bone marrow, which is an essential component in myeloma-defining criteria. Modern imaging identifies osteolytic lesions, distinguishes solitary plasmacytoma from MM, and evaluates the presence of extramedullary disease. Read More

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February 2022

Evaluation of extramedullary plasmacytoma of the larynx with radiologic and histopathological findings.

Radiologia (Engl Ed) 2022 Jan-Feb;64(1):69-73

Departamento de Anatomía Patológica, Facultad de Medicina de la Universidad Ondokuz Mayis, Samsun, Turkey.

Extramedullary plasmacytoma (EMP) is a plasma cell neoplasm of soft tissue without bone marrow involvement or other systemic characteristics of multiple myeloma. Approximately 80%-90% of EMPs involve the head and neck region, especially in the nasal cavity, paranasal sinuses, tonsillar fossa, and oral cavity. An EMP of the larynx is extremely rare and is a locally destructive lesion without systemic spread. Read More

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February 2022

Esophageal Plasmacytoma Revealed by Persistent Hiccups: A Case Report and Literature Review.

Case Rep Gastrointest Med 2022 31;2022:2242768. Epub 2022 Jan 31.

Department of Hematology and Bone Marrow Transplantation, Mohammed VI University Hospital, Cadi Ayyad University, Marrakesh 40080, Morocco.

Introduction: Solitary extramedullary plasmacytoma (SEP) is a rare neoplasm that is derived from monoclonal proliferation of plasma cells in the soft tissues or organs arising outside the bone marrow. It is present in about 3% of all plasma cell tumors and originates mainly from the upper respiratory tract and nasopharynx. Involvement of the esophagus is exceptionally seen in cases of SEP. Read More

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January 2022

Potential effect of epigenetic drugs in the treatment of multiple-site extramedullary plasmacytoma involving the respiratory system: a case report and review of the literature.

Transl Cancer Res 2021 Sep;10(9):4262-4273

Department of Hematology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China.

We report the case of a 23-year-old man with a medical history of idiopathic thrombocytopenic purpura (ITP) and newly diagnosed with the Epstein-Barr virus (EBV)-positive multiple-site extramedullary plasmacytoma (EMP), which involves the respiratory system. The patient was referred to our hospital because of progressive nasal congestion and nasal mass. Nasopharyngoscopy and bronchoscopy were performed. Read More

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September 2021

Single-Cell Transcriptomes Combining with Consecutive Genomics Reveal Clonal Evolution and Gene Regulatory Networks in Relapsed and Refractory Multiple Myeloma.

Front Cell Dev Biol 2021 5;9:794144. Epub 2022 Jan 5.

Department of Hematology, Zhongshan Hospital, Fudan University, Shanghai, China.

This study attempted to investigate how clonal structure evolves, along with potential regulatory networks, as a result of multiline therapies in relapsed/refractory multiple myeloma (RRMM). Eight whole exome sequencing (WES) and one single cell RNA sequencing (scRNA-seq) were performed in order to assess dynamic genomic changes in temporal consecutive samples of one RRMM patient from the time of diagnosis to death (about 37 months). The 63-year-old female patient who suffered from MM (P1) had disease progression (PD) nine times from July 2017 [newly diagnosed (ND)] to Aug 2020 (death), and the force to drive branching-pattern evolution of malignant PCs was found to be sustained. Read More

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January 2022

Inositol Polyphosphate 4-Phosphatase Type II Is a Tumor Suppressor in Multiple Myeloma.

Front Oncol 2021 5;11:785297. Epub 2022 Jan 5.

Department of Hematology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.

Inositol polyphosphate-4-phosphatase type II (INPP4B) has been identified as a tumor suppressor, while little is known about its expression and function in multiple myeloma (MM). In this study, we evaluated the expression of in 28 cases of newly diagnosed MM patients and 42 cases of extramedullary plasmacytoma (EMP) patients compared with normal plasma cells and found that low INPP4B expression was correlated with poor outcomes in MM patients. Moreover, expression of INPP4B in seven MM cell lines was all lower than that in normal plasma cells. Read More

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January 2022

Duodenal Ulcer with Massive Gastrointestinal Hemorrhage as an Initial Manifestation in Multiple Myeloma with Extramedullary Disease: A Case Report.

Medicina (Kaunas) 2022 Jan 16;58(1). Epub 2022 Jan 16.

Department of Surgery, Division of Colon and Rectal Surgery, Songshan Branch, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan.

Plasma cell neoplasms are characterized by dysregulated proliferation of mature B cells, which can present with either single (solitary plasmacytoma) or systemic (multiple myeloma (MM)) involvement. MM with extramedullary plasmacytoma (EMP) is a rare disease that accounts for approximately 3-5% of all plasmacytomas. EMP with gastrointestinal (GI) system involvement is an even rarer entity, accounting for <1% of MM cases. Read More

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January 2022