1,654 results match your criteria Plasmacytoma Extramedullary


A Problem of Classification: 2 Cases of Epstein-Barr Virus + Primary Cutaneous Plasmacytoma Arising in Immunocompetent Elderly Patients.

Am J Dermatopathol 2021 Jun 2. Epub 2021 Jun 2.

Department of Pathology, Lisbon Institute of Oncology, Lisbon, Portugal; Department of Dermatology, Kempf and Pfaltz Histological Diagnostics, University Hospital Zurich, Zurich, Switzerland; Kempf und Pfaltz Histologische Diagnostik, Zurich, Switzerland; Dermatopathology Friedrichshafen, Friedrichshafen, Germany; and Department of Pathology, St Thomas' Hospital, London, United Kingdom.

Abstract: Primary extramedullary plasmacytoma is rare monoclonal proliferation of plasma cells, which arise in various nonosseous anatomic locations without detectable underlying systemic disease. Historically, cutaneous infiltrates rich in mature neoplastic plasma cells have fallen into one of the following categories, plasmacytoma, lymphoplasmacytic lymphoma, and marginal zone lymphoma, which included immunocytoma. Since 2005, each of these was subsumed under the marginal zone lymphoma umbrella, largely on the basis of acknowledged diagnostic difficulties in some of these cases. Read More

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Solitary extramedullary plasmacytoma of the parotid gland in a patient with mixed connective tissue disease.

J Oral Maxillofac Pathol 2021 Mar 19;25(Suppl 1):S18-S21. Epub 2021 Mar 19.

Department of Oral and Maxillofacial Surgery, General Hospital George Papanikolaou, Thessaloniki, Greece.

Solitary extramedullary plasmacytomas of the head and neck region are rare entities. Very few have been described in the parotid gland. They can clinically and radiologically mimic the rather common benign tumors of the parotid gland (pleomorphic adenoma and Wharthin's tumor), and subsequently the need careful consideration by the involving surgeon and pathologist is needed for a proper diagnosis. Read More

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Solitary extramedullary plasmacytoma of the nasopharynx: The role of flow cytometry.

Oral Oncol 2021 May 26:105351. Epub 2021 May 26.

Second Department of Internal Medicine and Research Unit, Hematology Unit, National and Kapodistrian University of Athens, "Attikon" University General Hospital, Athens, Greece. Electronic address:

Extramedullary plasmacytoma (EMP) represents a distinct yet rare entity among the plasma cell neoplasms. Given its rarity, no therapeutic consensus has been met. We report the case of a 57-year-old man with a one-year history of nasal congestion and occasional dyspnoea. Read More

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Cutaneous involvement by multiple myeloma presenting as erythematous indurated plaques at the site of cardiac pacemaker insertion.

JAAD Case Rep 2021 Jun 24;12:54-57. Epub 2021 Apr 24.

Dermatology Department, Fiona Stanley Hospital, Murdoch, Western Australia, Australia.

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Relapsing Multiple Myeloma Presenting as Cardiac Tamponade and Obstructive Uropathy.

Cureus 2021 Apr 15;13(4):e14503. Epub 2021 Apr 15.

Hematology and Medical Oncology, Baylor Scott & White Medical Center - Temple, Temple, USA.

Cardiac tamponade is a rare manifestation of relapsing extramedullary multiple myeloma and portends poor prognosis. No cases of cardiac tamponade with co-occurring renal obstruction from plasmacytoma have been reported in the literature, making this case a unique presentation of relapsing multiple myeloma. The presence of known malignancy should not limit our differential diagnosis when evaluating patients with signs of cardiac tamponade. Read More

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Spinal cord compression due to a solitary, bulky plasmacytoma of posterior mediastinum.

Radiol Case Rep 2021 Jul 30;16(7):1622-1627. Epub 2021 Apr 30.

Hematology Department, Hospital de Clinicas "Dr. Manuel Quintela". Av Italia sn,11600. Montevideo, Uruguay.

Solitary plasmacytoma is a rare clonal plasma cell tumor, representing 2-5% of plasma cell disorders. The standard treatment is local radiotherapy. However, in some cases, its use is limited by the size and/or location of the mass. Read More

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Sinonasal Extramedullary Plasmacytoma With Rare Osteolytic Lesions.

Cureus 2021 Mar 31;13(3):e14220. Epub 2021 Mar 31.

Orthopedics, General Hospital of Patras, Patras, GRC.

Plasmacytomas are malignant tumors characterized by abnormal monoclonal proliferation of plasma cells. They originate either from bone or soft tissue and could be primary or a part of a systemic process during the course of multiple myeloma. Extramedullary plasmacytomas (EPs) in the sinonasal tract or nasopharynx are rare and mostly presented as case reports. Read More

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Refractory multiple myeloma with extramedullary plasmacytoma of the spleen and suspicious teratoma: a rare case report and literature review.

Int J Clin Exp Pathol 2021 15;14(4):455-462. Epub 2021 Apr 15.

Department of Hematology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University Nanjing, PR China.

Multiple myeloma (MM) is a type of malignant disease that is characterized by a clonal proliferation of plasma cells within the bone marrow. Relapsed and refractory multiple myeloma (RRMM) is a subtype of MM that is unreactive to salvage therapy and progresses during treatment or within 60 days of the last therapy in patients who achieved a minimal response before progression of disease. This usually results in a poor prognosis. Read More

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Solitary Extramedullary Plasmacytoma Presenting as Asymptomatic Palatal Erythroplakia: Report of a Case.

Int J Environ Res Public Health 2021 04 4;18(7). Epub 2021 Apr 4.

School of Medicine, Vita-Salute San Raffaele University, 20132 Milan, Italy.

Solitary plasmacytoma (SP) is a rare malignant tumor of plasma cells with no systemic spread; however, when it disseminates and affects multiple skeletal sites, it is called multiple myeloma (MM). The etiology of solitary plasmacytoma is unknown, with two possible subtypes: solitary extramedullary plasmacytoma (EMP) and solitary bone plasmacytoma (SBP). We present a case of EMP arising as asymptomatic erythroplakia of the palate, which is rarely described in the literature. Read More

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Soft Tissue Extramedullary Plasmacytoma Leading to Cauda Equina Syndrome: Case Presentation and Clinical Considerations.

Cureus 2021 Mar 23;13(3):e14056. Epub 2021 Mar 23.

Family Medicine, Bariatric Medicine-Non Surgical Weight Loss Care, Ascension Sacred Heart, Pensacola, USA.

Cauda equina syndrome (CES) is a rare neurological emergency that requires prompt diagnosis and immediate surgical intervention for the best potential patient outcome. CES results from the compression of spinal roots along the lower spine usually at the level of L2 or below. It typically presents with severe low back pain, pain radiating to lower extremities, motor weakness, sensory loss, saddle anesthesia, bladder and bowel dysfunction. Read More

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Paraneoplastic ganglioradiculoneuritis in a cat with a plasma cell tumour.

JFMS Open Rep 2021 Jan-Jun;7(1):20551169211003806. Epub 2021 Mar 31.

Southfields Veterinary Specialists, Laindon, UK.

Case Summary: An 8-year-old neutered female domestic longhair cat was presented for investigation of a 48 h history of lethargy and pelvic limb ataxia. MRI of the spinal cord and vertebral column (C1 to sacrum) and brain was unremarkable. Lumbar cerebrospinal fluid analysis revealed pleocytosis and increased protein concentration. Read More

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Solitary extramedullary plasmacytoma presenting as an adrenal tumor: case report and literature review.

Gland Surg 2021 Mar;10(3):1158-1164

Department of General Surgery, The Third Xiangya Hospital of Central South University, Changsha, China.

Solitary extramedullary plasmacytoma, an extremely rare case which accounts for about 3% of all plasma cell neoplasms, often occurs in the head and neck region such as para nasal sinuses, nasal cavity and oral cavity, it also occurs in the lymph nodes, lungs, thyroid, intestine, liver, pancreas, testis, breast, or skin. Isolated primary plasmacytoma of adrenal is extremely rare and only nine documented cases have been reported in the literature. We are presenting the 10 case which is the youngest patient until now with symptoms of fever and hepatosplenomegaly. Read More

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Role of FDG PET in the staging of multiple myeloma.

Skeletal Radiol 2021 Apr 4. Epub 2021 Apr 4.

Division of Musculoskeletal Imaging and Intervention, Massachusetts General Hospital and Harvard Medical School, Boston, USA.

F-Fluorodeoxyglucose (FDG) PET has been used for staging of hematologic malignancies for years. In multiple myeloma, this imaging modality can be used in many different scenarios, including initial staging, evaluation of treatment response, and investigation of residual disease or early relapse. FDG PET-CT has excellent diagnostic performance, similar to other advanced imaging modalities such as whole-body CT and MRI, and it is particularly helpful for the assessment of extramedullary disease. Read More

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Optic nerve head plasmacytoma as a manifestation of multiple myeloma.

Taiwan J Ophthalmol 2021 Jan-Mar;11(1):97-100. Epub 2021 Feb 10.

Department of Ophthalmology, Emory University, Atlanta, GA, USA.

Extramedullary disease in multiple myeloma is uncommon and associated with a poorer prognosis. Extramedullary disease involving the orbit is even more unusual, with optic nerve involvement being rare. We describe an optic nerve head plasmacytoma in a 45-year-old female in the setting of systemic relapsed, refractory IgA kappa multiple myeloma. Read More

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February 2021

Expert review on soft-tissue plasmacytomas in multiple myeloma: definition, disease assessment and treatment considerations.

Br J Haematol 2021 Mar 16. Epub 2021 Mar 16.

Berlín, Germany.

In this review, two types of soft-tissue involvement in multiple myeloma are defined: (i) extramedullary (EMD) with haematogenous spread involving only soft tissues and (ii) paraskeletal (PS) with tumour masses arising from skeletal lesions. The incidence of EMD and PS plasmacytomas at diagnosis ranges from 1·7% to 4·5% and 7% to 34·4% respectively. EMD disease is often associated with high-risk cytogenetics, resistance to therapy and worse prognosis than in PS involvement. Read More

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Extramedullary Plasmacytoma of the breast in a patient with Multiple Myeloma.

J Radiol Case Rep 2020 Dec 31;14(12):14-23. Epub 2020 Dec 31.

Department of Radiology, UC Davis Health, Sacramento, California, USA.

Extramedullary plasmacytoma of the breast is rare. It is important to recognize the imaging findings and include it as a differential consideration in multiple myeloma patients with a breast mass. A 74-year-old woman undergoing chemotherapy for relapsed multiple myeloma presented with a palpable mass in her right breast. Read More

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December 2020

EBV-Positive Plasmacytomas Involving a Nasopharyngeal Angiofibroma in an Adolescent.

Pediatr Dev Pathol 2021 May-Jun;24(3):264-268. Epub 2021 Mar 8.

Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, Ohio.

We report comprehensive characterization of an unusual collision tumor comprising extramedullary plasmacytomas and nasopharyngeal angiofibroma in a pediatric patient, which has yet to be reported. Histologically, the nasopharyngeal angiofibroma showed typical morphology with a diffuse, dense plasmacytic infiltrate in the stroma. The neoplastic plasma cells showed a spectrum of well-differentiated, plasmablastic, and anaplastic morphology, Epstein-Barr virus encoded RNA (EBER) positivity, and aberrant immunophenotype. Read More

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Cauda Equina Syndrome as the Initial Presentation of Concurrent Plasmacytoma and Multiple Myeloma.

Cureus 2021 Jan 24;13(1):e12888. Epub 2021 Jan 24.

Internal Medicine, Brandon Regional Hospital, Tampa, USA.

Multiple myeloma is a hematological malignancy characterized by an abnormal proliferation of monoclonal plasma cells. In some occurrences, plasma cell proliferation results in a solitary lesion (solitary bone plasmacytoma or extramedullary plasmacytoma with minimal bone marrow involvement). Approximately 50% of patients with solitary plasmacytoma develop multiple myeloma within 10 years after the initial diagnosis. Read More

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January 2021

Detection of Nasal Solitary Extramedullary Plasmacytoma on 18F-FDG PET/CT Imaging.

Clin Nucl Med 2021 Feb 20. Epub 2021 Feb 20.

From the Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province Academician (Expert) Workstation of Sichuan Province, Luzhou, Sichuan, People's Republic of China.

Abstract: A 46-year-old man presented with a 3-month history of epistaxis. CT and MRI scan showed a soft tissue mass in the left nasal cavity. An excisional biopsy of the mass revealed extramedullary plasmacytoma. Read More

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February 2021

Intracranial Plasmacytoma Mimicking a Cavernous Sinus Meningioma.

Cureus 2021 Jan 15;13(1):e12716. Epub 2021 Jan 15.

Neurosurgery, Cleveland Clinic Florida, Weston, USA.

Extramedullary plasmacytomas involving the cavernous sinus are rare manifestations of multiple myeloma, and management strategies for such a pathology are not extensively discussed in the literature. In this case report, we describe the case of a patient presenting with a cavernous sinus syndrome secondary to a presumed meningioma. Surgical intervention was avoided as a computed tomography-guided biopsy was performed yielding the diagnosis of a cavernous sinus plasmacytoma. Read More

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January 2021

A Giant Solitary Adrenal Plasmacytoma in a Patient with HIV: A Rare Case Report and Review of the Literature.

Case Rep Urol 2021 3;2021:6654437. Epub 2021 Feb 3.

Department of Urology, Mohamed VI University Hospital Center, Mohamed I University, Oujda, Morocco.

Solitary extramedullary plasmacytoma (EMP) involving the adrenal gland is an extremely rare malignancy. We report a case of a solitary adrenal plasmacytoma in an HIV-positive 50-year-old woman on antiretroviral therapy who presented with a rapidly progressing lumbar left masse. A CT scan objectified a locally advanced left adrenal mass measuring 135mm long axis. Read More

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February 2021

Amyloidosis, extramedullary plasmacytoma, and light chain deposition disease: impressive results of daratumumab therapy.

Pol Arch Intern Med 2021 03 11;131(3):297-298. Epub 2021 Feb 11.

Department of Hematology, Jagiellonian University Medical College, Kraków, Poland.

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Extramedullary plasmacytoma involving rectum: A case report and literature review.

Radiol Case Rep 2021 Apr 26;16(4):785-788. Epub 2021 Jan 26.

Medical Imaging Center, First Affiliated Hospital, Jinan university, No. 613 West Huangpu Avenue, Tianhe District, Guangzhou 510630, Guangdong, China.

Extramedullary plasmacytoma (EMP) of the gastrointestinal tract is an extreme rarity. Clinical manifestations of EMPs are varied, depending on the position and progress of tumor. Here we report a case of an EMP involving rectum in an 80-year-old, male patient with a change of bowel habit. Read More

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Intraocular solitary extramedullary plasmacytoma presenting as unilateral anterior and intermediate uveitis preceded by refractory glaucoma.

BMC Ophthalmol 2021 Jan 30;21(1):66. Epub 2021 Jan 30.

University of Sydney, Sydney, Australia.

Background: Solitary extramedullary plasmacytoma (SEP) is a localised proliferation of monoclonal plasma cells involving soft tissue with no or minimal bone marrow involvement and no other systemic evidence of multiple myeloma. Intraocular involvement is exceedingly rare.

Case Presentation: We report a 78-year-old man who was referred with glaucoma in the right eye. Read More

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January 2021

A rare case of primary solitary endobronchial plasmacytoma.

Thorac Cancer 2021 03 27;12(6):958-961. Epub 2021 Jan 27.

Division of Pulmonology and Allergy, Department of Internal Medicine, College of Medicine, Yeungnam University and Regional Center for Respiratory Diseases, Yeungnam University Medical Center, Daegu, South Korea.

Extramedullary plasmacytoma (EMP) is a rare plasma cell tumor involving the organs but without bone marrow involvement or the characteristics of multiple myeloma. Primary solitary endobronchial plasmacytoma is extremely rare. Here we present the case of an 86-year-old male ex-smoker who visited our outpatient clinic for an endobronchial mass in the left upper lobe of the lung. Read More

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Unusual presentation of a soft palate mass: A rare case report of solitary extramedullary plasmacytoma.

Int J Surg Case Rep 2021 Feb 15;79:193-197. Epub 2021 Jan 15.

Department of Oto-Rhino-Laryngology, Head and Neck Surgery, Casablanca University Hospital, Casablanca, Morocco.

Introduction: Plasmacytoma is a rare clonal neoplastic disorder of bone marrow that originates from plasma cells. It usually presents as a multiple myeloma (MM). Less than 5% of patients present with either a single bone lesion as a solitary bone plasmacytoma (SBP) or, even more rarely, as a soft tissue mass of monoclonal plasma cells representing a solitary extra medullary plasmacytoma (SEP). Read More

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February 2021

Extramedullary plasmacytoma of the pancreas diagnosed by EUS-guided fine-needle biopsy (with videos).

Endosc Ultrasound 2021 Mar-Apr;10(2):143-144

Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province, China.

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January 2021

Persistent orofacial pain associated with nasopharyngeal extramedullary plasmacytoma.

Spec Care Dentist 2020 Sep 28;40(5):519-524. Epub 2020 Jul 28.

Department of Oral Medicine, University of Pennsylvania, School of Dental Medicine, Philadelphia, Pennsylvania.

Orofacial pain (OFP) disorders affect the maxillofacial complex and typically involve other locations in the head and neck. Common etiologies of OFP disorders include odontogenic sources, temporomandibular disorders, neuropathic pain, chemosensory disorders, and headaches. Less commonly, benign and malignant neoplasms can be associated with OFP complaints. Read More

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September 2020

Utilization of radiation therapy in multiple myeloma: trends and changes in practice.

Ann Hematol 2021 Mar 12;100(3):735-741. Epub 2021 Jan 12.

Division of Hematology-Oncology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.

Plasma cell disorders including plasmacytomas and multiple myeloma (MM) are exquisitely radiosensitive, and thus, radiation therapy (XRT) is used effectively in their management. The role of XRT in the setting of novel MM therapeutics has not been explored. The 2016 National Cancer Database (NCDB) for MM with patients diagnosed between 2004 and 2013 was studied. Read More

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F-FDG PET/CT in the Evaluation of Solitary Extramedullary Plasmacytoma: A Case Series.

Asia Ocean J Nucl Med Biol 2021 ;9(1):56-61

Department of Radiation Oncology, Gujarat Cancer and Research Institute, Asarwa, Ahmedabad,Gujarat, India.

The role of fluorine-18-fluorodeoxyglucose positron emission tomography/ computed tomography (F-FDG PET/CT) in patients with multiple myeloma (MM) and other plasma cell disorders is well-known. Solitary plasmacytoma (SP), an extremely rare form within this entity accounting for approximately 4% of plasma cell malignancies, can be classified as solitary bone plasmacytoma (SBP) or solitary extramedullary plasmacytoma (SEMP). Extramedullary plasmacytoma (EMP) is a rare neoplasm characterized by the monoclonal proliferation of plasma cells outside the bone marrow. Read More

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January 2021