10,308 results match your criteria Plasmacytoma Extramedullary


The roles of lncRNA in hepatic fibrosis.

Cell Biosci 2018 6;8:63. Epub 2018 Dec 6.

1Medical College, China Three Gorges University, 8 Daxue Road, Xiling District, Yichang, 443002 China.

Increasing evidence indicates that long non-coding RNAs (lncRNAs) regulate gene or protein expression; however, their function in the progression of hepatic fibrosis remains unclear. Hepatic fibrosis is a continuous wound-healing process caused by numerous chronic hepatic diseases, and the activation of hepatic stellate cells (HSCs) is generally considered to be a pivotal step in hepatic fibrosis. In the process of hepatic fibrosis, some lncRNAs regulates diverse cellular processes. Read More

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December 2018

Long Noncoding RNA Plasmacytoma Variant Translocation 1 (PVT1) Promotes Colon Cancer Progression via Endogenous Sponging miR-26b.

Med Sci Monit 2018 Dec 1;24:8685-8692. Epub 2018 Dec 1.

Department of Hepatopancreatobiliary Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, Liaoning, China (mainland).

BACKGROUND Recently, long noncoding RNAs (lncRNAs) have received wide attention in the area of tumor progression. Dysregulation of lncRNAs has been shown to participated in colon cancer, a known malignant tumor. This study aimed to identify the way lncRNA PVT1 affects the progression of colon cancer. Read More

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December 2018
2 Reads

Sudden and unexpected death due to intracranial sellar extramedullary plasmacytoma.

J Forensic Leg Med 2018 Nov 26;61:89-91. Epub 2018 Nov 26.

Institute od Pathology, Faculty of Medicine, Slovak Medical University and Cytopathos Ltd., Limbova 12, 833 03 Bratislava, Slovakia. Electronic address:

The incidence of sudden death caused by undiagnosed primary intracranial neoplasm in young adults is extremely low. The aim of the work is to present a case report of the sudden death of a 24-year-old woman. The autopsy has revealed enlargement of sella turcica with an intrasellar tumorous mass extending into the adjacent basal parts of the brain. Read More

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November 2018
2 Reads

Conjunctival Colloid Milium.

Cornea 2018 Nov 27. Epub 2018 Nov 27.

Department of Pathology, Vision Research Foundation, Sankara Nethralaya, Chennai, India.

Purpose: To describe a rare case of conjunctival colloid milium.

Methods: Case report.

Results: We report a 45-year-old woman with a history of a slow-growing, painless mass extending from the medial canthal region to the inferior fornix and the inferior bulbar conjunctiva associated with redness. Read More

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November 2018
1 Read

Discovery platform for inhibitors of IgH gene enhancer activity.

Authors:
Nathan G Dolloff

Cancer Biol Ther 2018 Nov 27:1-11. Epub 2018 Nov 27.

a Department of Cellular and Molecular Pharmacology & Experimental Therapeutics , Medical University of South Carolina , Charleston , SC , USA.

Immunoglobulin heavy chain (IgH) translocations are common and early oncogenic events in B cell and plasma cell malignancies including B cell non-Hodgkin's lymphoma (NHL) and multiple myeloma (MM). IgH translocations bring oncogenes into close proximity with potent enhancer elements within the IgH locus, leading to oncogene up-regulation. As IgH enhancer activity is tightly controlled by B cell lineage-specific signaling and transcriptional networks, we hypothesized that IgH enhancers are potentially druggable targets/elements. Read More

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November 2018
3 Reads

Marginal resection of solitary plasmacytoma in the anterior region of the mandible and dental implant rehabilitation: Report of an unusual case.

Ann Med Surg (Lond) 2018 Dec 8;36:158-161. Epub 2018 Nov 8.

Department of Oral and Maxillofacial Surgery, Universidade Positivo, Curitiba, Brazil.

Introduction: Plasmacytoma describes a neoplastic proliferation of plasma cells affecting different groups of patients according to location, and may demonstrate heterogeneous tumor progression and survival rate. The present article describes a case of solitary plasmacytoma in the mandible

Presentation Of Case: A 57-year-old male smoker was referred to the oral and maxillofacial service with extensive injury, approximately 4-5 cm in size, involving the anterior inferior region of mandible. After confirming diagnosis of plasmacytoma through incisional biopsy, because it was a recurrent lesion, excision of the lesion was performed through marginal resection of the mandible under general anesthesia. Read More

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December 2018
3 Reads

A Case Report of a Breast Implant-Associated Plasmacytoma and Literature Review of Non-ALCL Breast Implant-Associated Neoplasms.

Aesthet Surg J 2018 Nov 24. Epub 2018 Nov 24.

University of Cincinnati Medical Center, Cincinnati, OH.

Lymphomas associated with breast implants are rare, with the most common being anaplastic large cell lymphoma (ALCL). Non-ALCL breast implant-associated lymphomas are even more rare, with only a small handful of such neoplasms reported to date. Given the need to better understand these pathologies as well as the increasing clinical and media attention to these diseases, we review the available literature of hematolymphoid neoplasms other than ALCL associated with breast implants and describe the first case of a patient diagnosed with a primary breast implant-associated plasmacytoma. Read More

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November 2018

Plasmacytoma of thyroid clinically and morphologically mimicking primary thyroid carcinoma.

Cytopathology 2018 Nov 21. Epub 2018 Nov 21.

Department of Pathology, Radiology.

Plasma cell neoplasms may have a spectrum of clinical presentation ranging from asymptomatic proliferation to single/multiple mass lesions in medullary/ extramedullary sites. Extramedullary plasmacytoma (EMP) is a rare tumor of the soft tissue without theinvolvement of bone marrow which most commonly affects the head and neck region and may precede multiple myeloma (MM) (1). Thyroid can rarely be a site for EMP or may be infiltrated by systemic multiple myeloma. Read More

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November 2018
2 Reads

Next generation flow for minimally-invasive blood characterization of MGUS and multiple myeloma at diagnosis based on circulating tumor plasma cells (CTPC).

Blood Cancer J 2018 Nov 19;8(12):117. Epub 2018 Nov 19.

Cancer Research Center (IBMCC-CSIC/USAL-IBSAL); Cytometry Service (NUCLEUS) and Department of Medicine, University of Salamanca (USAL), Salamanca, Spain.

Here, we investigated for the first time the frequency and number of circulating tumor plasma cells (CTPC) in peripheral blood (PB) of newly diagnosed patients with localized and systemic plasma cell neoplasms (PCN) using next-generation flow cytometry (NGF) and correlated our findings with the distinct diagnostic and prognostic categories of the disease. Overall, 508 samples from 264 newly diagnosed PCN patients, were studied. CTPC were detected in PB of all active multiple myeloma (MM; 100%), and smoldering MM (SMM) patients (100%), and in more than half (59%) monoclonal gammopathy of undetermined significance (MGUS) cases (p <0. Read More

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November 2018
6 Reads

Epstein - Barr virus association with plasma cell neoplasms.

Histol Histopathol 2018 Nov 19:18066. Epub 2018 Nov 19.

Department of Pathology and Laboratory Medicine, University of California Irvine (UCI), Irvine, CA, USA.

Aims: Epstein-Barr virus (EBV) expression has been reported in several hematopoietic and non-hematopoietic disorders but its expression in plasma cell neoplasms has been largely limited to immunodeficiency-related cases such as in the setting of post-organ transplantation or human immunodeficiency virus (HIV) infection. The aim of this study is to evaluate the association of EBV with plasma cell neoplasms, mainly in immunocompetent patients.

Methods And Results: We retrospectively studied 147 cases of patients with different plasma cell neoplasms (109 plasma cell myelomas, 22 plasmacytomas, and 16 monoclonal gammopathy cases). Read More

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November 2018
5 Reads

Updates on the Genetics and Molecular Subtypes of Urothelial Carcinoma and Select Variants.

Surg Pathol Clin 2018 Dec 17;11(4):713-723. Epub 2018 Oct 17.

Department of Medicine, Genitourinary Oncology Service, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.

Urothelial carcinoma is a morphologically and genomically heterogeneous disease that exhibits a wide spectrum of morphologic features and molecular alterations and subtypes. Classic urothelial carcinoma (not otherwise specified) is the most common tumor type that develops in the urinary bladder but many, well-documented, variant histologies are commonly encountered in approximately one-third of invasive urothelial carcinoma, including squamous, glandular, micropapillary, sarcomatoid, small cell/neuroendocrine, clear cell, lymphoepithelioma-like, and plasmacytoid types, among others. In this review, we provide an update on the molecular advances in urothelial carcinoma and some of its variant histologies. Read More

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December 2018
1 Read

Intracranial multiple myeloma with intraparenchymal involvement: Case report and literature review.

J Clin Neurosci 2018 Nov 12. Epub 2018 Nov 12.

Department of Neurosurgery, the Royal Melbourne Hospital, Parkville, VIC, Australia.

Intraparenchymal extension of multiple myeloma is a rare manifestation of the disease. Here, we present a case of a patient with multiple myeloma lesions situated adjacent to the meninges and intraparenchymally. Read More

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November 2018
1 Read

Retroperitoneal extramedullary plasmacytoma: A case report and review of the literature.

Medicine (Baltimore) 2018 Nov;97(46):e13281

First Department of Thoracic Radiotherapy, Shanxi Cancer Hospital, Taiyuan, China.

Rationale: The incidence of extramedullary plasmacytoma (EMP) accounts for 3% to 4% of all cases of generalized plasmacytoma. The most common pathogenic sites are the head and the neck. It is noteworthy that the pathogenic site in this case is extraperitoneal, which is uncommon in clinical practice. Read More

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November 2018
4 Reads

Differential Diagnosis and Treatment Modality of Parasellar Plasmacytoma: Clinical Series and Literature Review.

World Neurosurg 2018 Nov 7. Epub 2018 Nov 7.

Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, China.

Background: Parasellar plasmacytomas are rare tumors arising from the sellar region that should be considered in differential diagnosis for lesions involving the sella and clivus. Prior to surgical pathologic examination, parasellar plasmacytomas are often misdiagnosed as invasive pituitary adenomas or chordomas due to the similarity of clinical presentation and imaging findings.

Methods: We retrospectively reviewed 5 patients with parasellar plasmacytoma who underwent endonasal endoscopic tumor resection in Beijing Tiantan Hospital between January 2008 and January 2018. Read More

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November 2018
5 Reads

Classification of Solitary Plasmacytoma, Is it more Intricate than Presently Suggested? A Commentary.

J Cancer 2018 10;9(21):3894-3897. Epub 2018 Oct 10.

Hematopathology Service, Pathology Department, Soroka Univ. Med. Ctr. and Faculty of Health Sciences, Ben Gurion University of the Negev, Beer-Sheva, Israel.

A query regarding the definition and the classification of solitary plasmacytoma is apparently still pending. The clinical course, the response to treatment and the propensity to progress to plasma cell myeloma, are all a function of the classification which must be established on a firm basis. Solitary plasmacytoma should be recognized in the continuum of the plasma cell neoplasms. Read More

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October 2018
6 Reads

PVT1 protects diabetic peripheral neuropathy via PI3K/AKT pathway.

Authors:
L Chen H-Y Gong L Xu

Eur Rev Med Pharmacol Sci 2018 Oct;22(20):6905-6911

Department of Neurology, Xiangyang Central Hospital, Xiangyang, China.

Objective: To investigate whether Plasmacytoma Variant Translocation 1 (PVT1) could regulate the occurrence and progression of diabetic peripheral neuropathy (DPN) via activating the PI3K/AKT pathway.

Materials And Methods: Diabetes model in rats was constructed by streptozotocin (STZ) injection. PVT1 expression in diabetic rats and control rats was detected by quantitative real time-polymerase chain reaction (qRT-PCR). Read More

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October 2018
3 Reads

Surgery for Pulmonary Fungal Infections Complicating Hematological Malignancies.

Korean J Thorac Cardiovasc Surg 2018 Oct 5;51(5):350-355. Epub 2018 Oct 5.

Department of General Thoracic Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital.

Background: The complication rate of fungal disease is higher among patients with hematological malignancies. We investigated the clinicobacteriological outcomes of resected pulmonary fungal infections complicating hematological malignancies.

Methods: Between 2001 and 2017, 21 patients with pulmonary fungal infections complicating hematological malignancies underwent resection, and their clinical records and survival were retrospectively reviewed. Read More

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October 2018
5 Reads

Plasmablastic lymphoma masquerading solitary plasmacytoma in an immunocompetent patient.

BMJ Case Rep 2018 Oct 21;2018. Epub 2018 Oct 21.

Lismore Cancer Care and Haematology Unit, Northern NSW Local Health District, Lismore, New South Wales, Australia.

We report a case of a middle-aged woman who initially presented with a painful solitary destructive lesion at fifth lumbar vertebra. The initial diagnosis of plasma cell neoplasm was made based on limited histological information obtained from fragmented tissue sample. Clinicopathological findings were consistent with a solitary plasmacytoma, and she was treated with definitive radiotherapy. Read More

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October 2018
8 Reads

PCR-based clonality analysis of antigen receptor gene rearrangements in canine cutaneous plasmacytoma.

Vet J 2018 Nov 20;241:31-37. Epub 2018 Sep 20.

North Lab, 2-8-35, Hondori, Shiroisi-ku, Sapporo, Hokkaido 003-0027, Japan.

Plasmacytomas are discrete, B cell-derived, round cell tumours that sometimes are difficult to distinguish from canine cutaneous histiocytomas or T cell lymphosarcomas (lymphomas). Diagnosis of plasmacytomas relies on morphological observations and immunohistochemistry for multiple myeloma oncogene-1 (MUM-1) and cluster of differentiation 3 (CD3). Clonality testing often is used as an adjunct diagnostic tool to examine lymphoproliferative diseases. Read More

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November 2018
4 Reads

Place of Sterotactic Radiotherapy in Treatment of Extramedullary Plasmocytoma.

J Craniofac Surg 2018 Nov;29(8):e807

Kayseri Education and Research Hospital, Department of Radiation Oncology, Kayseri, Turkey.

In conclusion, extramedullary plasmacytoma (EMPs) initially develop as localized disease. These tumors are quite sensitive to radiotherapy (RT) and the response is often complete recovery after RT. In addition, highly sensitive, conformal radiosurgery can be preferred to conventional RT; however, further studies are needed to define indications and therapeutic fractions in stereotactic RT of plasmacytoma since guidelines and clinical trials are lacking. Read More

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November 2018
4 Reads

LncRNA PVT1 regulates growth, migration, and invasion of bladder cancer by miR-31/ CDK1.

J Cell Physiol 2018 Oct 14. Epub 2018 Oct 14.

School of Public Health, Taishan Medical University, Tai'an, China.

Purpose: The aim of our study was to validate the sway of long noncoding RNA (lncRNA) plasmacytoma variant translocation 1 (PVT1) on the metabolism and growth of bladder cancer cells by microRNA-31 (miR-31)/cyclin-dependent kinase 1 ( CDK1).

Methods: The Gene Expression Omnibus database was used for analyzing the differentially expressed lncRNA and messenger RNA (mRNA) in bladder cancer tissues, with the highly expressed lncRNA PVT1 and mRNA CDK1 screened out. The expression level of PVT1 was detected by quantitative reverse-transcription polymerase chain reaction, cell viability by Cell Counting Kit-8 assay, cell proliferation and scratch by 5-bromo-2'-deoxyuridine assay, cell migration and invasion by transwell assays, the expression level of CDK1 by immunohistochemistry and western blot analysis, transcription factor targeting by dual-luciferase assay, and the effect of PVT1 on bladder cancer growth by nude mice tumor formation experiment. Read More

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October 2018
6 Reads

LncRNA PVT1 promotes malignant progression in squamous cell carcinoma of the head and neck.

J Cancer 2018 8;9(19):3593-3602. Epub 2018 Sep 8.

Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, People's Republic of China.

Long non-coding RNAs (lncRNAs) are potentially critical regulators of cancer malignant behaviours. Aberrant expression and dysfunction of lncRNA PVT1 have been reported in multiple human cancers. However, its role in squamous cell carcinoma of the head and neck (SCCHN) remains largely unknown. Read More

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September 2018
5 Reads

Plasmacytoma-like post-kidney-transplant lymphoproliferative disorder confined to renal allograft and urinary tract: A case report.

Nephrol Ther 2018 Dec 6;14(7):544-547. Epub 2018 Oct 6.

Service de néphrologie, CHU de Rennes, site Pontchaillou, 2, rue Henri le Guilloux, 35033 Rennes cedex 9, France.

Post-transplantation lymphoproliferative disorder (PTLD) is a well-know complication after organ transplantation. We report a case of a patient who developed an extramedullary plasmacytoma-like PTLD around his transplanted kidney treated with standard multiple myeloma chemotherapy. Three years after benefiting of a deceased donor kidney transplant for an end stage kidney disease secondary to nephroangiosclerosis, our patient developed an extra-medullary plasmacytoma confined to the transplant compartment. Read More

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December 2018
8 Reads

Case of solitary plasmacytoma of tibia.

BMJ Case Rep 2018 Oct 7;2018. Epub 2018 Oct 7.

Pathology, Manipal Academy of Higher Education, Manipal, Karnataka, India.

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October 2018
5 Reads

[Extramedullary Plasmacytoma].

Rofo 2018 Nov 8;190(11):1006-1009. Epub 2018 Oct 8.

Diagnostic and Interventional Radiology, Universität Leipzig Medizinische Fakultät, Leipzig, Germany.

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November 2018
2 Reads

Plasmacytoma variant translocation 1 (PVT1) regulates trophoblast viability, proliferation, and migration and is downregulated in spontaneous abortion.

Am J Reprod Immunol 2018 Sep 17:e13048. Epub 2018 Sep 17.

Department of Obstetrics and Gynecology, Renmin Hospital of Wuhan University, Wuhan, China.

Problem: Human pregnancy is a complex biological process, and spontaneous abortion is the most common complication of pregnancy. LncRNAs have been identified that play key roles in a variety of human diseases. Recently, lncRNAPVT1 was reported to relate to the pathogenesis and progression of pregnancy. Read More

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September 2018
12 Reads

Utility of Computed Tomography-guided Biopsy in Evaluation of Metastatic Spinal Lesions.

Asian J Neurosurg 2018 Jul-Sep;13(3):577-584

Department of Pathology, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India.

Introduction: Computed tomography (CT)-guided biopsy of spine is currently a valuable diagnostic tool and effective technique for diagnosing and planning a proper therapeutic strategy for certain spinal lesions. The reported diagnostic accuracy of core biopsy ranges from 77% to 97%.

Materials And Methods: We included all patients with spinal lesions suspicious of metastasis on magnetic resonance imaging, who presented between May 2012 and April 2014 and underwent CT-guided biopsy in our study. Read More

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October 2018

[A case of extramedullary plasmacytoma of the nasal cavity].

Authors:
M X Huo Z Liu Q X Liu

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Aug;32(15):1194-1195

A case of extramedullary plasmacytoma of the nasal cavity was reported and its mainly clinical manifestations were nasal obstruction, running nose and olfactory degeneration. Nasal endoscopy and paranasal sinus CT indicated tract tumor in left nasal (the nature to be investigated), the pathological result after surgical resection of the tumor suggests extramedullaryplasmacytoma (left nasal cavity).Clinical diagnosis was extramedullaryplasmacytoma (left nasal cavity), chronic sinusitis (left). Read More

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August 2018
1 Read

Multiple myeloma with pathologically proven skull plasmacytoma after a mild head injury: Case report.

Medicine (Baltimore) 2018 Sep;97(39):e12327

Department of Neurosurgery, the 2nd Hospital of Lanzhou University.

Rationale: MM is a malignant tumor originating from the plasma cells of the bone marrow. Central nervous system myelomatosis is very rare and may be a complication of MM.

Patient Concerns: A 60-year-old man presented with a slowly growing soft mass at his right frontal scalp after a mild head injury 6 months ago. Read More

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September 2018
1 Read

Solitary Extramedullary Plasmacytoma Mimicking Acute Subdural Hematoma.

World Neurosurg 2018 Dec 27;120:521-524. Epub 2018 Sep 27.

Department of Neurosurgery, University of Health Sciences, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey.

Background: Solitary extramedullary plasmacytoma (SEP) is a plasma cell neoplasm located outside the bone. It is rarely observed in the intracranial area. It is very difficult to diagnose this condition radiologically before surgery. Read More

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December 2018
2 Reads

Pancreatic Extramedullary Plasmacytoma Presenting as a Pancreatic Mass.

Clin Med Insights Gastroenterol 2018 24;11:1179552218801603. Epub 2018 Sep 24.

Department of Gastroenterology, Sinai Hospital, Baltimore, MD, USA.

Extramedullary plasmacytomas (EMP) are a subcategory of plasma cell neoplasm that involves organs outside the bone marrow. Involvement of the pancreas is relatively rare, reported in only 2.3% of autopsies. Read More

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September 2018
5 Reads

Breast plasmacytoma with associated amyloidosis mimicking breast carcinoma.

Breast J 2018 Nov 25;24(6):1071-1073. Epub 2018 Sep 25.

Department of Radiology, Loyola University Medical Center, Maywood, Illinois.

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November 2018
6 Reads
1.430 Impact Factor

Biliary Obstruction due to a Pancreatic Plasmacytoma.

Case Rep Gastrointest Med 2018 4;2018:9017617. Epub 2018 Sep 4.

Division of Gastroenterology, MedStar Washington Hospital Center, Washington, DC, USA.

Obstructive jaundice, weight loss, and anorexia often raise a concern for pancreatic malignancy. Although pancreatic adenocarcinoma is the most common form of pancreatic cancer, not all pancreatic malignancies are exocrine in origin. With advancement in endoscopic ultrasound with fine needle aspiration, it has become easier to make correct diagnosis. Read More

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September 2018
1 Read

Prognostic values of long noncoding RNA PVT1 in various carcinomas: An updated systematic review and meta-analysis.

Cell Prolif 2018 Dec 5;51(6):e12519. Epub 2018 Sep 5.

Department of Obstetrics and Gynecology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.

Cancers have been a worldwide health problem with a high mortality rate, but ideal biomarkers are not available to effectively screen and diagnose patients. Currently, an increasing number of long noncoding RNAs have been reported to be abnormally expressed in human carcinomas and play a vital role in tumourigenesis. Plasmacytoma variant translocation 1 (PVT1) is upregulated in various carcinomas, and its overexpression is associated with poor survival in cancer patients. Read More

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December 2018

Downregulation of lncRNA PVT1 expression inhibits proliferation and migration by regulating p38 expression in prostate cancer.

Oncol Lett 2018 Oct 14;16(4):5160-5166. Epub 2018 Aug 14.

Department of Urology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.

Long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 (PVT1) has been reported to be overexpressed in prostate cancer cells and associated with tumorigenesis in various types of cancer. However, the biological function of lncRNA PVT1 remains largely unknown. The aim of the present study was to investigate the effect of lncRNA PVT1 expression on the proliferation and migration of prostate cancer cells. Read More

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October 2018
2 Reads

Solitary extramedullary plasmacytoma of the rectum complicating ulcerative colitis.

Clin J Gastroenterol 2018 Sep 20. Epub 2018 Sep 20.

Department of Pathology, Nikko Medical Center, Dokkyo Medical University, Tochigi, Japan.

Solitary extramedullary plasmacytoma (EMP) arising in the rectum is an extremely rare clinical entity. Only ten cases have been reported in the English-language literature. We experienced a case of an EMP in the rectum of a 55-year-old man with an 8-year history of proctitis-type ulcerative colitis (UC). Read More

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September 2018
6 Reads

Clinico-radiologic features and management of hematological tumors in the breast: a case series.

Breast Cancer 2018 Sep 18. Epub 2018 Sep 18.

Texas A&M Health Sciences Center, Dallas, TX, 75246, USA.

Hematological tumors arising in the breast are uncommon and require different treatment modalities dependent upon tumor type. Current treatment options include surgical excision, chemotherapy, and radiotherapy. Management of these breast malignancies are poorly outlined in the literature. Read More

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September 2018
5 Reads

Clinical and ophthalmological outcome of endoscopic transorbital surgery for cranioorbital tumors.

J Neurosurg 2018 Sep 14:1-9. Epub 2018 Sep 14.

Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine; and.

OBJECTIVE Cranioorbital tumors are complex lesions that involve the deep orbit, floor of the frontal bone, and lesser and greater wing of the sphenoid bone. The purpose of this study was to describe the clinical and ophthalmological outcomes with an endoscopic transorbital approach (TOA) in the management of cranioorbital tumors involving the deep orbit and intracranial compartment. METHODS The authors performed endoscopic TOAs via the superior eyelid crease incision in 18 patients (16 TOA alone and 2 TOA combined with a simultaneous endonasal endoscopic resection) with cranioorbital tumors from September 2016 to November 2017. Read More

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September 2018
7 Reads

Total en bloc spondylectomy for primary tumors of the lumbar spine.

Medicine (Baltimore) 2018 Sep;97(37):e12366

Department of Orthopedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.

This was a retrospective clinical study.This study aimed to evaluate our institution's experience with total en bloc spondylectomy (TES) in patients treated for primary lumbar spine tumors and investigate postoperative clinical outcomes.TES is a widely accepted by spinal and musculoskeletal surgical oncologists and results in favorable health-related quality of life outcomes. Read More

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September 2018

Plasmacytoma of the mesentery.

J Postgrad Med 2018 Oct-Dec;64(4):255-257

Department of Medical Oncology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India.

Extramedullary plasmacytoma represents 3%-5% of all plasma cell neoplasms. Plasmacytomas of the mesentery are extremely rare. We report the case of a 56-year-old man who presented with an abdominal mass and was diagnosed to have plasmacytoma of the mesentery. Read More

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September 2018
6 Reads

LncRNA PVT1 promotes ovarian cancer progression by silencing miR-214.

Cancer Biol Med 2018 Aug;15(3):238-250

Department of Gynecologic Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin; Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.

Objective: Emerging evidence indicates that long non-coding RNAs (lncRNAs) are critical in carcinogenesis and progression of ovarian cancer. This study aimed to explore the functions and molecular mechanisms of plasmacytoma variant translocation I (PVT1) in ovarian cancer.

Methods: PVT1 and miR-214 were detected by qRT-PCR assays in ovarian cancer tissues and cells. Read More

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August 2018
4 Reads

Recurrence of Extramedullary Plasmacytomas Involving Lymph Nodes and Pancreas Revealed by 68Ga-DOTATATE and 18F-FDG PET/CT.

Clin Nucl Med 2018 Dec;43(12):936-938

Department of Hematology, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing, People's Republic of China.

A 40-year-old man with history of extramedullary plasmacytoma in nasal cavity presented with right submandibular mass for 3 months. F-FDG PET/CT demonstrated mild radioactivity in the right submandibular mass, pancreatic mass, and lymph nodes in the abdomen and left hilum of the lung. To differentiate from pancreatic neuroendocrine tumor, Ga-DOTATATE PET/CT was performed. Read More

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December 2018
4 Reads

Abducens Nerve Palsy as Initial Presentation of Multiple Myeloma and Intracranial Plasmacytoma.

J Clin Med 2018 Sep 3;7(9). Epub 2018 Sep 3.

College of Medicine, University of Kentucky, Lexington, KY 40506, USA.

Central Nervous System (CNS) involvement in multiple myeloma and/or multifocal solitary plasmacytoma is rare. Although they are unique entities, multiple myeloma (MM) and plasmacytoma represent a spectrum of plasma cell neoplastic diseases that can sometimes occur concurrently. Plasmacytomas very often present as late-stage sequelae of MM. Read More

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September 2018
6 Reads

Concomitant Extramedullary Plasmacytoma in the Oropharynx and Hypopharyngeal Squamous Cell Carcinoma.

Case Rep Otolaryngol 2018 31;2018:1463218. Epub 2018 Jul 31.

Department of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University, Tokyo, Japan.

We report a rare case of hypopharyngeal squamous cell carcinoma occurring synchronously with extramedullary plasmacytoma (EPM) of the oropharynx in which radiotherapy was used as the curative treatment. A 73-year-old man presented with a sore throat that had persisted for 6 months. Examination revealed a superficial, smooth tumorous lesion at the base of his tongue with a red hue in the oropharynx. Read More

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July 2018
9 Reads

Knockdown of Long Noncoding RNA Plasmacytoma Variant Translocation 1 with Antisense Locked Nucleic Acid GapmeRs Exerts Tumor-Suppressive Functions in Human Acute Erythroleukemia Cells Through Downregulation of C-MYC Expression.

Cancer Biother Radiopharm 2018 Aug 24. Epub 2018 Aug 24.

Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences , Isfahan, Iran .

Objective: Acute erythroleukemia (AEL) is a subtype of acute myeloid leukemia (AML), with no specific treatment. Up- or downregulation of long noncoding RNAs (lncRNAs) is strongly associated with the formation and progression of many malignancies. Plasmacytoma variant translocation 1 (PVT1) is a significantly upregulated lncRNA in AML. Read More

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August 2018
14 Reads

Extramedullary plasmacytoma of the larynx: Literature review and report of a case who subsequently developed acute myeloid leukemia.

Oncol Lett 2018 Sep 19;16(3):2995-3004. Epub 2018 Jun 19.

Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.

Extramedullary plasmacytoma (EMP) of the larynx is an extremely rare plasma cell neoplasm outside of the bone marrow, which has not been previously well characterized. A case of laryngeal EMP who developed acute myeloid leukemia (AML) following treatment is described in the present study, as well as an extensive review of the relevant literature. An electronic literature search was performed in PubMed and all pertinent case reports and series in the English language from 1948-October 2017 were identified. Read More

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September 2018
2 Reads

Long non-coding RNA PVT1, a molecular sponge for miR-149, contributes aberrant metabolic dysfunction and inflammation in IL-1β-simulated osteoarthritic chondrocytes.

Biosci Rep 2018 Oct 28;38(5). Epub 2018 Sep 28.

Department of Orthopaedics, the Ninth Hospital of Xi'an, Xi'an, Shaanxi 710054, P.R. China.

Osteoarthritis (OA), a common form of degenerative joint disease, is typified by inflammatory response and the loss of cartilage matrix. Long non-coding RNAs (lncRNAs) are emerging as a new player in gene regulation and exert critical roles in diverse physiologic and pathogenic processes including OA. The lncRNA plasmacytoma variant translocation 1 (PVT1) has been implicated in cancer, diabetes and septic acute kidney injury. Read More

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October 2018
2 Reads

[A case report of cutaneous plasmacytosis].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Aug;50(4):752-754

Department of Dermatology, Peking University People's Hospital, Beijing 100044, China.

A collection of plasma cells in the skin can represent a broad spectrum of disease entities. Secondary syphilis, primary cutaneous plasmacytoma, primary cutaneous plasmacytosis, cutaneous lymphoid hyperplasia and nodular amyloidosis are considered possible differential diagnoses. The primary cutaneous plasma cell disorders can range from malignant to benign plasma cell neoplasms. Read More

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August 2018
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Tonsillar plasmacytoma in a dog.

Can Vet J 2018 Aug;59(8):851-854

Veterinary Teaching Hospital (Iwaki, Upchurch, Vilar-Saavedra), Michigan State University Veterinary Diagnostic Laboratory (Monahan, Smedley), Michigan State University College of Veterinary Medicine Ringgold Standard Institution - East Lansing, Michigan, USA.

A 10-year-old greyhound dog was presented because of an incidental finding of a tonsillar mass. Excisional surgical biopsy was performed and the dog was diagnosed with an incompletely resected plasma cell tumor. Adjuvant therapy was declined. Read More

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August 2018
12 Reads