102,778 results match your criteria Plaque Psoriasis


Selection and characterization of protective anti-chikungunya virus single domain antibodies.

Mol Immunol 2018 Dec 11;105:190-197. Epub 2018 Dec 11.

US Naval Research Laboratory, Center for Biomolecular Science and Engineering, 4555 Overlook Ave SW, Washington, DC 20375, USA. Electronic address:

Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that causes an arthralgia febrile illness that has affected millions of people on three continents. Previously, neutralizing monoclonal antibodies that have prophylactic and therapeutic activity were found to remove virus in joint tissues, thereby reducing the severity of symptoms in mice and non-human primates. In this study, we sought to develop thermostable small recombinant antibodies against CHIKV for future diagnostic, prophylactic and therapeutic applications. Read More

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December 2018
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Levels of circulating soluble LR11, a regulator of smooth muscle cell migration, are highly associated with atherosclerotic plaques in patients with carotid artery stenosis.

Clin Chim Acta 2018 Dec 11. Epub 2018 Dec 11.

Department of Clinical-Laboratory and Experimental-Research Medicine, Toho University Sakura Medical Center, 564-1 Shimoshizu, Sakura 285-8741, Japan. Electronic address:

Background: The levels of plasma sLR11, released from intimal SMCs, are positively associated with intima-media thickness (IMT) in asymptomatic subjects. We have evaluated the yet unknown pathological significance of sLR11 for plaque conditions in patients with carotid artery stenosis.

Methods: The presence of LR11 in carotid plaques was investigated using autopsy specimens. Read More

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December 2018

Reproducibility of quantitative coronary computed tomography angiography in asymptomatic individuals and patients with acute chest pain.

PLoS One 2018 14;13(12):e0207980. Epub 2018 Dec 14.

Department of Cardiology, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.

Purpose: Quantitative computed tomography (QCT) provides important prognostic information of coronary atherosclerosis. We investigated intraobserver and interobserver QCT reproducibility in asymptomatic individuals, patients with acute chest pain without acute coronary syndrome (ACS), and patients with acute chest pain and ACS.

Methods: Fifty patients from each cohort, scanned between 01/02/2010-14/11/2013 and matched according to age and gender, were retrospectively assessed for inclusion. Read More

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December 2018

Cytokine, chemokine and growth factor levels in peri-implant sulcus during wound healing and osseointegration after piezosurgical versus conventional implant site preparation: Randomized, controlled, split-mouth trial.

J Periodontol 2018 Dec 14. Epub 2018 Dec 14.

Division of Oral Diseases, Department of Dental Medicine, Karolinska Institute, Stockholm, Sweden.

Aim: To evaluate the cytokine, chemokine and growth factor levels in peri-implant sulcular fluid (PISF) during healing and osseointegration at osteotomy sites prepared either with piezosurgery (PS) or drills.

Materials And Methods: Fourteen patients having contralateral partial edentulism in the posterior maxilla were enrolled and 38 osteotomies were prepared. Implants were placed with one-stage surgery. Read More

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December 2018

Clinical indices and local levels of inflammatory biomarkers in per-implant health of obese and nonobese individuals.

Clin Implant Dent Relat Res 2018 Dec 13. Epub 2018 Dec 13.

Department of Periodontology, Faculty of Dentistry, Ziauddin University, Karachi, Pakistan.

Background: Obesity seem to regulate peri-implant health. It is proposed that peri-implant crevicular fluid (PICF) levels of interleukin (IL)-1β and IL-6 are higher in obese as compared to nonobese individuals.

Objective: The purpose of the present clinico-laboratory study is to estimate and compare the clinical and radiographic indices and PICF levels of IL-1β and IL-6 among obese and nonobese patients. Read More

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December 2018

Nonobstructive angioscopy in patient with atherosclerotic renal artery stenosis.

J Cardiol Cases 2014 Jan 13;9(1):18-21. Epub 2013 Dec 13.

Cardiovascular Center, Amagasaki Central Hospital, 1-12-1 Shio-e, Amagasaki, Hyogo 661-0976, Japan.

Few applications of angioscopy for evaluating atherosclerosis of the abdominal aorta have been described. We report the demonstration of atherosclerotic yellow plaque by nonobstructive angioscopy in a patient with left renal artery stenosis. Computed tomography angiography showed stenosis in one of the left renal arteries in a 65-year-old man who presented with renal impairment and hypertension. Read More

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January 2014

Vasospasm-induced acute myocardial infarction-Thrombus formation without thrombogenic lesion at the culprit.

J Cardiol Cases 2013 Oct 31;8(4):138-141. Epub 2013 Aug 31.

Cardiovascular Division, Osaka Police Hospital, 10-31 Kitayama-cho, Tennoji-ku, Osaka 543-0035, Japan.

Although plaque rupture is the major cause of acute myocardial infarction, vasospasm is also known as a potential cause of acute myocardial infarction. However, it is very rare and is sometimes difficult to diagnose correctly. A 30-year-old male patient with suspected unstable angina pectoris who received catheterization in 1999 had normal coronary artery but positive result in the provocation test of vasospasm. Read More

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October 2013

Acute myocardial infarction caused by a floating thrombus in the ascending aorta: A role of CD34-positive endothelial cells.

J Cardiol Cases 2013 Aug 23;8(2):e88-e90. Epub 2013 May 23.

Department of Cardiology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori 036-8562, Japan.

A 49-year-old woman was transferred to our hospital with acute-onset chest pain. Her electrocardiogram showed complete atrioventricular block and bradycardia with ST-segment elevation in the inferior leads, and she presented with cardiogenic shock. She was diagnosed with inferior acute myocardial infarction (AMI), and subsequent emergency cardiac catheterization was performed. Read More

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Kounis syndrome triggered by diclofenac sodium injection which leads to myocardial infarction and cardiac arrest.

J Cardiol Cases 2013 Jul 6;8(1):e17-e19. Epub 2013 Apr 6.

Department of Cardiology, Ataturk University Faculty of Medicine, Erzurum, Turkey.

Allergic reactions due to drugs may lead to different clinical conditions. Acute coronary syndromes triggered by Type 1 hypersensitivity reactions due to drug intake are known as "Kounis syndrome." Vasospasm occurring in normal coronary arteries (Type 1) and plaque rupture (Type 2) are two variants of this syndrome; both caused by vasoactive and inflammatory mediators due to hypersensitivity reaction. Read More

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Deceived incidence of acute coronary syndrome by measurement of FFR: Diagnostic gap of vulnerable plaque between physiology and morphology.

J Cardiol Cases 2013 Jul 8;8(1):e7-e8. Epub 2013 Apr 8.

Division of Cardiology, Nippon Medical School, Tokyo, Japan.

A 67-year-old male was admitted because of acute myocardial infarction (AMI). An emergent coronary angiography showed a total occlusion in the left anterior descending artery, and a stent was deployed. Moderate lesion stenosis was found in the right coronary artery (RCA). Read More

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Arterial repair after bare-metal stent implantation in peripheral arteries is delayed compared to that in coronary arteries: A case report of pathological evaluation.

J Cardiol Cases 2016 Sep 14;14(3):74-77. Epub 2016 May 14.

Kansai Rosai Hospital Cardiovascular Center, Amagasaki, Japan.

Despite widespread use of endovascular therapy with bare-metal stent (BMS) implantation in patients with peripheral artery disease (PAD), arterial healing has not been well examined in this setting. An 84-year-old man with PAD received BMS implantation at the right external iliac artery (EIA, Epic 8.0 mm × 100 mm) and superficial femoral artery (SFA, SMART Control 8. Read More

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September 2016

Recurrent systemic embolism caused by descending thoracic aortic mural thrombus in a young cannabis abuser.

J Cardiol Cases 2016 Mar 10;13(3):93-95. Epub 2015 Dec 10.

Department of Cardiology, CHRU de Brest, Hôpital de la Cavale Blanche, Brest, France.

Aortic mural thrombi are a rare cause of peripheral arterial embolic events. We report the case of a young man with prior history of Buerger's disease and marijuana abuse. He presented visceral infarctions due to descending thoracic aortic mobile pedunculated thrombus with complex atherosclerosis. Read More

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A case of floating thrombus in the ascending aorta that caused recurrent peripheral arterial embolic events.

J Cardiol Cases 2015 Aug 21;12(2):57-60. Epub 2015 May 21.

Department of Cardiology, Gifu Prefectural Tajimi Hospital, Tajimi, Japan.

We report the case of a 62-year-old man with recurrent arterial embolisms to his arms caused by a thrombosis of the ascending aorta. He had developed a left brachial artery embolism 8 years previously, but presented with a right brachial artery embolus on this occasion. A clot-like mass was seen in the ascending aorta on computed tomography without significant atherosclerosis. Read More

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ST-segment elevation myocardial infarction in a patient with anomalous origin of left circumflex coronary artery.

J Cardiol Cases 2015 Apr 13;11(4):120-123. Epub 2015 Feb 13.

Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.

We present a case of ST-segment elevation myocardial infarction in the territory of an anomalous left circumflex coronary artery running through the retroaortic region. coronary imaging with intravascular ultrasound visualized the usual atherosclerotic change and subsequent plaque rupture and thrombus formation at the culprit lesion. The clarification of pathologic mechanisms underlying the myocardial infarction case could provide information about pathophysiology of atherosclerotic development in anomalous left circumflex coronary artery, and could help in decision-making regarding the management strategy. Read More

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Increase in serum triglyceride was associated with coronary plaque vulnerability in a patient with rheumatoid arthritis.

J Cardiol Cases 2014 Aug 6;10(2):54-57. Epub 2014 Jun 6.

Department of Cardiovascular Medicine, The University of Tokushima Graduate School of Health Biosciences, Tokushima, Japan.

Rates of morbidity and mortality from cardiovascular disease are high in patients with rheumatoid arthritis (RA); however, the mechanisms and biomarkers that reflect coronary plaque vulnerability have not yet been established. We present a case of acute coronary syndrome (ACS) presumably caused by exacerbation of chronic inflammation of RA, in which an abrupt increase in serum triglyceride was seen on the day of onset of ACS but not during effort angina. This case suggests that RA patients with an abrupt increase in triglyceride need intensive care including anti-platelet and statin therapy for the prevention of coronary plaque rupture. Read More

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Endovascular management of subclavian artery stenosis using balloon expandable covered stents.

J Cardiol Cases 2011 Jun 22;3(3):e159-e162. Epub 2011 Mar 22.

Division of Cardiovascular Medicine, Temple University Hospital, Philadelphia, PA, USA.

Covered stents have primarily been used in coronary arteries for exclusion of perforations, aneurysms, and fistulas. The use of covered stents to treat occlusive disease of first-order aortic branches has been proposed as a method to reduce intimal hyperplasia and improve patency rates, since they exclude plaque and prevent luminal encroachment through open struts, but their selective use in subclavian artery stenosis has not been previously reported. We present three cases of subclavian artery stenosis that were successfully treated via a percutaneous approach with covered stents. Read More

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Atherosclerotic plaque burden evaluated from neck to groin: effect of gender and cardiovascular risk factors.

Int J Cardiovasc Imaging 2018 Dec 13. Epub 2018 Dec 13.

Department of Cardiovascular Imaging, Diagnóstico Maipú, Av Maipú 1668, B1602ABQ, Vicente López, Buenos Aires, Argentina.

We explored the impact of gender and cardiovascular risk factors (RF) in the distribution and burden of coronary and extra-coronary atherosclerotic plaques among patients undergoing ECG-gated thoracoabdominal computed tomography angiography (CTA) from the supra-aortic trunks to the femoral arteries. We included a consecutive cohort of patients who underwent ECG-gated thoracoabdominal aortic CTA from the supra-aortic trunks to the pubic symphysis. We evaluated the number of coronary segments with plaques [segment-involvement score (SIS)]; and the extra-coronary atherosclerotic plaque burden, comprising the aorta and supra-aortic trunks, iliofemoral arteries, and visceral arteries (extra-coronary SS). Read More

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December 2018

Quantification of Infectious Sendai Virus Using Plaque Assay.

Bio Protoc 2018 Nov;8(21)

Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, USA.

Sendai virus (SeV) is an enveloped, single-stranded RNA virus of the family . SeV is a useful tool to study its infectious pathomechanism in immunology and the pathomechanism of a murine model of IgA nephropathy. Virus quantification is essential not only to determine the original viral titers for an appropriate application, but also to measure the viral titers in samples from the harvests from experiments. Read More

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November 2018
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Evaluation of efficacy of intermaxillary fixation screws versus modified arch bar for intermaxillary fixation.

Natl J Maxillofac Surg 2018 Jul-Dec;9(2):134-139

Department of Oral and Maxillofacial Surgery, K.M. Shah Dental College, Vadodara, Gujarat, India.

Aim: This study aimed to evaluate the efficacy of intermaxillary fixation (IMF) screws and modified arch bar.

Materials And Methods: This study is a randomized clinical trial in which all participants were divided into two groups of ten in each group and designated as Group A and Group B. In Group A, IMF was achieved by the use of four to six 2×8mm stainless steel IMF screws. Read More

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December 2018

Handheld versus conventional vascular ultrasound for assessing carotid artery plaque.

Int J Cardiol 2018 Dec 5. Epub 2018 Dec 5.

Department of Biomedical and Molecular Sciences, Queen's University, 18 Stuart Street, Kingston, K7L 3N6, ON, Canada; Department of Medicine, Division of Cardiology, Cardiovascular Imaging Network at Queen's (CINQ), Queen's University, 76 Stuart Street, Kingston, K7L 2V7, ON, Canada. Electronic address:

Background: Coronary Artery Disease (CAD) is the leading cause of death worldwide. Ultrasound-detected carotid plaque has been previously shown to predict significant CAD. Despite this evidence, carotid plaque assessment has not been implemented in cardiac risk screening, likely due to the cost associated with a formal carotid ultrasound examination. Read More

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December 2018

The gingival health status of 8-12 year-old children in Damascus city in Syria during the Syrian Crisis: a cross-sectional epidemiological oral health survey.

BMC Res Notes 2018 Dec 13;11(1):887. Epub 2018 Dec 13.

Paediatric Dentistry Department, Faculty of Dentistry, Damascus University, Damascus, Syria.

Objective: The aim of this study was to assess the current gingival health status in children aged 8-12 years in Damascus city. No contemporary data was available with an immense need for studies evaluating the gingival health status in Syrian children, especially under the current circumstances of the Syrian crisis.

Results: The study followed the school-based health survey model using stratified random cluster sampling. Read More

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December 2018

Multicenter Retrospective Analysis of Implant Overdentures Delivered with Different Design and Attachment Systems: Results Between One and 17 Years of Follow-Up.

Dent J (Basel) 2018 Dec 11;6(4). Epub 2018 Dec 11.

Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, School of Dentistry, University of Pavia, 27100 Pavia, Italy.

Purpose: To analyze implant and prosthetic survival rates, complications, patient satisfaction, and biological parameters of patients rehabilitated with implant overdentures (IOV) on splinted and nonsplinted implants and different attachment systems, in function for one to 17 years.

Methods: This retrospective study evaluated data collected from patients rehabilitated with implant overdentures between January 2001 and December 2016 in nine different centers. Outcome measures were implant and prosthetic success rates, mechanical complications, marginal bone loss (MBL), oral health impact profile (OHIP), bleeding on probing, and plaque index. Read More

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December 2018

Impact of coronary plaque geometry on plaque vulnerability and its association with the risk of future cardiovascular events in patients with chest pain undergoing coronary computed tomographic angiography-the GEOMETRY study: Protocol for a prospective clinical trial.

Medicine (Baltimore) 2018 Dec;97(49):e13498

Department of Medical Clinic III - Internal Medicine, University of Medicine and Pharmacy 'Gr.T.Popa', Iasi, Romania.

Introduction: Coronary computed tomography angiography (CCTA) has emerged as a valuable noninvasive imaging tool for assessing atheromatous plaque morphology and composition, and several CCTA features have been validated as reliable indicators of the plaque-associated risk. However, the role of lesion geometry as a CCTA feature of plaque vulnerability has not been investigated so far.

Material And Methods: Here we present the study protocol of the GEOMETRY trial, a prospective, single center, cohort study in which we aim to investigate the relationship between plaque geometry (as expressed by cross-sectional and longitudinal plaque eccentricity) and the risk for major adverse cardiac events (MACE) during 2 years of follow-up, in order to validate plaque eccentricity as a new CCTA marker of coronary plaque vulnerability. Read More

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December 2018

Advanced Methods for the Investigation of Cell Contact Dynamics in Endothelial Cells Using Florescence-Based Live Cell Imaging.

J Vasc Res 2018 Dec 13;55(6):350-364. Epub 2018 Dec 13.

Institute of Anatomy and Vascular Biology, Westfälische Wilhelms-Universität Münster, Münster,

Endothelial cells of the vascular system are dynamic cells whose molecular adaptability is decisive for the adjustment of homeostasis and organ perfusion. Advanced microscopic techniques, automation processing, and image analysis software was shown to improve the understanding of vascular biology. In this work, we describe advanced methods that allow investigating the dynamics of endothelial cell contacts. Read More

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December 2018

Characterization of gene deletion mutants of Cyprinid herpesvirus 3 (koi herpesvirus) lacking the immunogenic envelope glycoproteins pORF25, pORF65, pORF148 and pORF149.

Virus Res 2018 Dec 10. Epub 2018 Dec 10.

Institute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany. Electronic address:

Cyprinid herpesvirus 3 (CyHV-3) or koi herpesvirus is a global pathogen causing mass mortality in koi and common carp, against which improved vaccines are urgently needed. In this study we investigated the role of four nonessential, but immunogenic envelope glycoproteins encoded by members of the ORF25 gene family (ORF25, ORF65, ORF148 and ORF149) during CyHV-3 replication. Single deletion of ORF65 did not affect in vitro replication, and deletion of ORF148 even slightly enhanced virus growth on common carp brain (CCB) cells, deletions of ORF25 or ORF149 led to reduced plaque sizes and virus titers, which was due to delayed entry into host cells. Read More

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December 2018

Everolimus delayed and suppressed cytomegalovirus DNA synthesis, spread of the infection, and alleviated cytomegalovirus infection.

Antiviral Res 2018 Dec 10. Epub 2018 Dec 10.

Department of Virology, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan. Electronic address:

Everolimus is an inhibitor of mammalian target of rapamycin (mTOR) and reduces the risk of cytomegalovirus (CMV) infection in transplant recipients. Everolimus inhibits mTOR complex 1, which regulates factors involved in several crucial cellular functions and is required for CMV replication. However, it is not clear how everolimus regulates CMV replication and prevents and alleviates CMV infection. Read More

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December 2018

Clinical and Radiographic Evaluation of Early Loaded Maxillary Anterior Implants: Three-Year Follow-up.

Int J Periodontics Restorative Dent 2019 Jan/Feb;39(1):123-129

The aim of this study was to evaluate clinical and radiologic results up to 3 years in patients treated with early loading of anterior implants supporting single-tooth all-ceramic restorations. Twenty-four patients were treated with 29 screw-type implants in the anterior maxilla. The implants were evaluated by clinical and radiographic parameters. Read More

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December 2018

Evaluation of TurboHawk Plaque Rotation System in Treatment of Superficial Femoral Atherosclerosis.

Med Sci Monit 2018 Dec 13;24:9026-9031. Epub 2018 Dec 13.

Department of Vascular Surgery, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China (mainland).

BACKGROUND To investigate the curative effect and utility of the TurboHawk plaque circumcision system in the treatment of patients with superficial femoral atherosclerosis (SFA). MATERIAL AND METHODS We retrospectively analyzed 60 cases of superficial femoral atherosclerotic stenosis and occlusion treated with the TurboHawk plaque circumcision system for endovascular ablation of the superficial femoral artery in the People's Hospital of Xinjiang Uygur Autonomous Region between January 2016 and December 2017. RESULTS The sample comprised of 50 male and 10 female patients with an average age of 65±4. Read More

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December 2018

Subgingival lipid A profile and endotoxin activity in periodontal health and disease.

Clin Oral Investig 2018 Dec 12. Epub 2018 Dec 12.

Faculty of Medicine and Dentistry, University of Plymouth, Plymouth, PL4 8AA, UK.

Objectives: Regulation of lipopolysaccharide (LPS) chemical composition, particularly its lipid A domain, is an important, naturally occurring mechanism that drives bacteria-host immune system interactions into either a symbiotic or pathogenic relationship. Members of the subgingival oral microbiota can critically modulate host immuno-inflammatory responses by synthesizing different LPS isoforms. The objectives of this study were to analyze subgingival lipid A profiles and endotoxin activities in periodontal health and disease and to evaluate the use of the recombinant factor C assay as a new, lipid A-based biosensor for personalized, point-of-care periodontal therapy. Read More

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December 2018

Subgingival Microbial Changes During the First 3 Months of Fixed Appliance Treatment in Female Adult Patients.

Curr Microbiol 2018 Dec 13. Epub 2018 Dec 13.

Department of Orthodontics, Peking University School and Hospital of Stomatology, 22 Zhongguancun Avenue South, Haidian District, Beijing, 100081, People's Republic of China.

Although periodontal diseases during fixed appliance treatment are a common issue, few studies have focused on the clinical and microbial factors associated with orthodontic appliances. Hence, we investigated changes in the subgingival microbial community and their association with periodontal changes at the early stage of fixed appliance treatment. Subgingival plaques from ten female patients with fixed appliances were obtained at three time points: before, 1 month and 3 months after the placement of the brackets (T0, T1 and T2). Read More

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December 2018

Evaluation of US and MRI techniques for carotid stenosis: a novel phantom approach.

Radiol Med 2018 Dec 12. Epub 2018 Dec 12.

Department of BIOMORF, University of Messina, Messina, Italy.

Carotid atherosclerosis is very important in the pathogenesis of cerebral ischemia. Ultrasonography (US) and magnetic resonance imaging (MRI) are the predominant noninvasive techniques capable to identify the presence and stage of intra-plaque hemorrage. In this work, we propose a novel dedicated phantom that can be used for both US and MRI scanners to evaluate carotid atherosclerotic lesions. Read More

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December 2018

Targeting Inflammation With Nanosized Drug Delivery Platforms in Cardiovascular Diseases: Immune Cell Modulation in Atherosclerosis.

Front Bioeng Biotechnol 2018 27;6:177. Epub 2018 Nov 27.

NEST Laboratory, Scuola Normale Superiore, Pisa, Italy.

Atherosclerosis (AS) is a disorder of large and medium-sized arteries; it consists in the formation of lipid-rich plaques in the intima and inner media, whose pathophysiology is mostly driven by inflammation. Currently available interventions and therapies for treating atherosclerosis are not always completely effective; side effects associated with treatments, mainly caused by immunodepression for anti-inflammatory molecules, limit the systemic administration of these and other drugs. Given the high degree of freedom in the design of nanoconstructs, in the last decades researchers have put high effort in the development of nanoparticles (NPs) formulations specifically designed for either drug delivery, visualization of atherosclerotic plaques, or possibly the combination of both these and other functionalities. Read More

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November 2018

Leptin upregulates smooth muscle cell expression of MMP-9 to promote plaque destabilization by activating AP-1 via the leptin receptor/MAPK/ERK signaling pathways.

Exp Ther Med 2018 Dec 12;16(6):5327-5333. Epub 2018 Oct 12.

Department of Cardiology, Dongguan Third People's Hospital, Dongguan, Guangdong 523326, P.R. China.

Leptin has been reported to be expressed in carotid atherosclerotic plaques, where it can promote lesion instability. Matrix metalloproteinases (MMPs) produced by smooth muscle cells (SMCs) are known to contribute to the weakening of atherosclerotic plaques via the degradation of extracellular matrix (ECM) proteins. The present study investigated whether leptin promotes plaque rupture by increasing the expression of MMP in SMCs and . Read More

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December 2018

Carotid thickness and atherosclerotic plaque stability, serum inflammation, serum MMP-2 and MMP-9 were associated with acute cerebral infarction.

Exp Ther Med 2018 Dec 16;16(6):5253-5257. Epub 2018 Oct 16.

Department of Neurosurgery, Jingmen First People's Hospital, Jingmen, Hubei 448000, P.R. China.

Correlations of carotid intima-media thickness (IMT), atherosclerotic plaque stability, serum inflammatory factors and serum matrix metalloproteinase (MMP)-2 and MMP-9 levels with the condition of disease in patients with acute cerebral infarction were analyzed to explore the predictive value of these risk factors. A total of 56 patients diagnosed with acute cerebral infarction in Jingmen First People's Hospital from February 2016 to January 2017 were selected and divided into the plaque stability group (n=25) and plaque instability group (n=31). Our results showed that the level of total cholesterol (TC) in the plaque instability group was significantly higher than that in the plaque stability group (P<0. Read More

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December 2018

The Emerging Role of Altered Cerebellar Synaptic Processing in Alzheimer's Disease.

Front Aging Neurosci 2018 27;10:396. Epub 2018 Nov 27.

Department of Pharmacy, School of Medicine, University of Naples Federico II, Naples, Italy.

The role of the cerebellum in Alzheimer's disease (AD) has been neglected for a long time. Recent studies carried out using transgenic mouse models have demonstrated that amyloid-β (Aβ) is deposited in the cerebellum and affects synaptic transmission and plasticity, sometimes before plaque formation. A wide variability of motor phenotype has been observed in the different murine models of AD, without a consistent correlation with the extent of cerebellar histopathological changes or with cognitive deficits. Read More

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November 2018

Evaluation of a Rapid Immunochromatographic Assay and Two Enzyme-Linked Immunosorbent Assays for Detection of IgM-class Antibodies to Zika Virus.

J Clin Microbiol 2018 Dec 12. Epub 2018 Dec 12.

Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN

There are currently five serologic assays available for detection of anti-Zika virus (ZIKV) IgM-class antibodies with United States Food and Drug Administration Emergency Use Authorization. Among these are the Chembio DDP Zika IgM system (Chembio DPP Zika ICA; Medford, NY), a rapid immunochromatographic assay (ICA), and the InBios ZIKV ™ 2.0 IgM antibody capture enzyme-linked immunosorbent assay (InBios ZIKV 2. Read More

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December 2018

centrin CEN-4 localizes to the putative MTOC and is dispensable for malaria parasite proliferation.

Biol Open 2018 Dec 12. Epub 2018 Dec 12.

School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham, UK

Centrins are calmodulin-like phosphoproteins present in the centrosome and play an active role in the duplication, separation and organization of centrosomal structures such as the microtubule-organizing centre (MTOC) during mitosis. They are also major components of the basal body of flagella and cilia. In spp. Read More

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December 2018

Relationship between plaque composition by virtual histology intravascular ultrasound and clinical outcomes after percutaneous coronary intervention in saphenous vein graft disease patients: study protocol of a prospective cohort study.

BMC Cardiovasc Disord 2018 Dec 12;18(1):233. Epub 2018 Dec 12.

Cardiovascular Institute, Tianjin Chest Hospital, No.261 Tai er zhuang Road, Jinnan District, Tianjin, 300222, People's Republic of China.

Background: Plaque composition and morphologic characteristics identified by virtual histology intravascular ultrasound (VH-IVUS) can determine plaques at increased risk of clinical events following percutaneous coronary intervention (PCI) among coronary artery disease (CAD) patients. However, there have been few studies to investigate the relationship between plaque composition of saphenous vein graft (SVG) by VH-IVUS and clinical outcomes in patients with saphenous vein graft disease (SVGD) undergoing PCI. The purpose of this study is to determine whether plaque components and characteristics by VH-IVUS can predict major adverse cardiac events (MACEs) among SVGD patients undergoing PCI. Read More

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December 2018

Deep neural networks for A-line-based plaque classification in coronary intravascular optical coherence tomography images.

J Med Imaging (Bellingham) 2018 Oct 3;5(4):044504. Epub 2018 Dec 3.

Case Western Reserve University, Department of Biomedical Engineering, Cleveland, Ohio, United States.

We develop neural-network-based methods for classifying plaque types in clinical intravascular optical coherence tomography (IVOCT) images of coronary arteries. A single IVOCT pullback can consist of microscopic-resolution images, creating both a challenge for physician interpretation during an interventional procedure and an opportunity for automated analysis. In the proposed method, we classify each A-line, a datum element that better captures physics and pathophysiology than a voxel, as a fibrous layer followed by calcification (fibrocalcific), a fibrous layer followed by a lipidous deposit (fibrolipidic), or other. Read More

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October 2018

Medicinal plants for gingivitis: a review of clinical trials.

Iran J Basic Med Sci 2018 Oct;21(10):978-991

Department of Pharmacy in Persian Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Objectives: Periodontal diseases are among prevalent oral health problems which may ultimately lead to severe complications in oral cavity. Herbal products can be designed as single or multicomponent preparations for better oral health. This study aims to review current clinical trials on the effectiveness of herbal products in gingivitis. Read More

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October 2018
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Investigation of out-of-plane motion artifacts in two-dimensional noninvasive vascular ultrasound elastography.

Phys Med Biol 2018 Nov 14. Epub 2018 Nov 14.

Laboratory of Biorheology and Medical Ultrasonics , University of Montreal Hospital Research Center, 900 St-Denis, Montreal, Quebec, CANADA.

Ultrasound noninvasive vascular elastography (NIVE) has shown its potential to measure strains of carotid arteries to predict plaque instability. When two-dimensional (2-D) strain estimation is performed, either in longitudinal or cross-sectional view, only in-plane motions are considered. The motions in elevation direction (i. Read More

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November 2018
2.761 Impact Factor

Coronary CT angiography-derived plaque quantification with artificial intelligence CT fractional flow reserve for the identification of lesion-specific ischemia.

Eur Radiol 2018 Dec 6. Epub 2018 Dec 6.

Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, USA.

Objectives: We sought to investigate the diagnostic performance of coronary CT angiography (cCTA)-derived plaque markers combined with deep machine learning-based fractional flow reserve (CT-FFR) to identify lesion-specific ischemia using invasive FFR as the reference standard.

Methods: Eighty-four patients (61 ± 10 years, 65% male) who had undergone cCTA followed by invasive FFR were included in this single-center retrospective, IRB-approved, HIPAA-compliant study. Various plaque markers were derived from cCTA using a semi-automatic software prototype and deep machine learning-based CT-FFR. Read More

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December 2018

Visualization of carotid vessel wall and atherosclerotic plaque: T1-SPACE vs. compressed sensing T1-SPACE.

Eur Radiol 2018 Dec 6. Epub 2018 Dec 6.

Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.

Objectives: To compare visualization of carotid plaques and vessel walls between 3D T1-fast spin echo imaging with conventional SPACE (T1-SPACE) and with a prototype compressed sensing T1-SPACE (CS-T1-SPACE) METHODS: This retrospective study was approved by the institutional review board. Participants comprised 43 patients (36 males, 7 females; mean age, 71 years) who underwent carotid MRI including T1-SPACE and CS-T1-SPACE. The quality of visualization for carotid plaques and vessel walls was evaluated using a 5-point scale, and signal intensity ratios (SRs) of the carotid plaques were measured and normalized to the adjacent sternomastoid muscle. Read More

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December 2018

Visualization of asymptomatic atherosclerotic disease for optimum cardiovascular prevention (VIPVIZA): a pragmatic, open-label, randomised controlled trial.

Lancet 2018 Dec 3. Epub 2018 Dec 3.

Unit of Epidemiology and Global Health, Umeå University, Umeå, Sweden.

Background: Primary prevention of cardiovascular disease often fails because of poor adherence among practitioners and individuals to prevention guidelines. We aimed to investigate whether ultrasound-based pictorial information about subclinical carotid atherosclerosis, targeting both primary care physicians and individuals, improves prevention.

Methods: Visualization of asymptomatic atherosclerotic disease for optimum cardiovascular prevention (VIPVIZA) is a pragmatic, open-label, randomised controlled trial that was integrated within the Västerbotten Intervention Programme, an ongoing population-based cardiovascular disease prevention programme in northern Sweden. Read More

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December 2018
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Use of Dual-Layered Stents in Endovascular Treatment of Extracranial Stenosis of the Internal Carotid Artery: Results of a Patient-Based Meta-Analysis of 4 Clinical Studies.

JACC Cardiovasc Interv 2018 Dec;11(23):2405-2411

Division of Cardiology, Department of Advanced Biomedical Sciences, University of Naples "Federico II," Naples, Italy.

Objectives: The aim of this study was to evaluate the clinical efficacy of dual-layered mesh-covered carotid stent systems (DLS) for carotid artery stenting (CAS).

Background: The need to minimize the risk for plaque debris prolapsing between stent struts following CAS has resulted in the development of DLS. Small clinical studies evaluating 2 available devices, Roadsaver and CGuard, have been recently published; none of these studies is sufficiently powered to test the role of common risk factors on the occurrence of stroke at 30 days post-CAS. Read More

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December 2018

A First-in-Human Evaluation of a Novel Mesh-Covered Stent for Treatment of Carotid Stenosis in Patients at High Risk for Endarterectomy: 30-Day Results of the SCAFFOLD Trial.

JACC Cardiovasc Interv 2018 Dec;11(23):2396-2404

Lankenau Heart Institute, Main Line Health, Wynnewood, Pennsylvania.

Objectives: The primary purpose of this study was the composite of major adverse events through 30 days post-index procedure or ipsilateral stroke from 30 days to 1 year (365 days). Presented here is the composite of death, stroke, and myocardial infarction (MI) through 30 days.

Background: Rates of minor stroke have been higher with carotid artery stenting (CAS) compared with carotid endarterectomy (CEA). Read More

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December 2018

Antiviral activity of propolis special extract GH 2002 against virus .

Pharmazie 2018 Dec;73(12):733-736

Propolis is a generic name for a biological substance produced by bees used for multiple purposes in folk medicine. Propolis special extract GH 2002 is crude propolis highly purified by a special procedure and freed from the accompanying substances like pollen, wax, resins. The cytotoxic and antiherpetic effect of propolis extracts against virus (VZV) was analysed in cell culture, and revealed a moderate cytotoxicity on lung fibroblasts with a CC of 380 μg/ml. Read More

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December 2018

Uncovering complex microbiome activities via metatranscriptomics during 24 hours of oral biofilm assembly and maturation.

Microbiome 2018 Dec 6;6(1):217. Epub 2018 Dec 6.

Department of Periodontics, University of Washington, Seattle, WA, 98195, USA.

Background: Dental plaque is composed of hundreds of bacterial taxonomic units and represents one of the most diverse and stable microbial ecosystems associated with the human body. Taxonomic composition and functional capacity of mature plaque is gradually shaped during several stages of community assembly via processes such as co-aggregation, competition for space and resources, and by bacterially produced reactive agents. Knowledge on the dynamics of assembly within complex communities is very limited and derives mainly from studies composed of a limited number of bacterial species. Read More

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December 2018

Plasma homocysteine levels and intracranial plaque characteristics: association and clinical relevance in ischemic stroke.

BMC Neurol 2018 Dec 6;18(1):200. Epub 2018 Dec 6.

Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, No.300 Guangzhou Road, Gulou district, Nanjing, 210029, Jiangsu Province, China.

Background: Elevated plasma homocysteine (Hcy) is an independent risk factor for ischemic stroke. This study aimed to evaluate the association between Hcy levels and intracranial plaque characteristics and to investigate their clinical relevance in ischemic stroke.

Methods: Ninety-four patients with intracranial atherosclerosis (ICAS) were enrolled. Read More

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December 2018