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Plast Reconstr Surg Glob Open 2020 Apr 27;8(4):e2754. Epub 2020 Apr 27.

Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italia.

Ledderhose disease (LD) is a rare plantar fibromatosis of the foot, frequently associated with Dupuytren disease. Collagenase of has recently revolutionized the way to treat Dupuytren disease. Nevertheless, the literature is still critically lacking about the use of collagenase injection in LD. Read More

J Surg Case Rep 2020 Feb 28;2020(2):rjz402. Epub 2020 Feb 28.

Department of Plastic and Reconstructive Surgery, Shiga University of Medical Science, Otsu-city, Japan.

Plantar fibromatosis (PF) is a rare benign disease. Here we report bilateral PF accompanied by Dupuytren's contracture in the right palm. Magnetic resonance imaging was useful in diagnosing PF, although biopsy was needed to rule out hemangioma. Read More

J Foot Ankle Surg 2019 Nov;58(6):1281-1284

Pathologist, Crozer Keystone Health System, Upland, PA.

Plantar fibromatosis, also known as Ledderhose's disease, is a rare disorder of benign fibroblast proliferation involving the plantar aponeurosis (i.e., plantar fascia). Read More

J Orthop Case Rep 2019 ;9(2):84-86

Department of Orthopedics, Sri Ramachandra Medical College, Chennai, TamilNadu, India.

Introduction: Ledderhose's disease, also known asplantar fibromatosis, is a rare benign nodular hyperplasia of the plantar aponeurosis. The disease is locally aggressive and can be managed very well conservatively. In patients who present with severe pain on weight-bearing might require surgical excision. Read More

Neurologist 2019 Sep;24(5):150-151

Department of Neurology, Federal Hospital of Servidores do Estado, Rio de Janeiro-RJ, Brazil.

Introduction: Dupuytren, Ledderhose, and Peyronie diseases are chronic fibrotic conditions related to progressive fibrosis of the palmar fascia, plantar fascia, and tunica albuginea, respectively. These conditions have been associated with antiepileptic drug use, mainly phenobarbital and primidone.

Case Report: A 71-year-old man developed simultaneous Dupuytren, Ledderhose, and Peyronie diseases after primidone use for essential tremor. Read More

Ir Med J 2019 04 11;112(4):919. Epub 2019 Apr 11.

Mater Misericordiae University Hospital, Eccles Street, Dublin 7

Aim To describe an uncommon clinical finding and raise awareness of its manifestation and associated conditions. Methods This case describes a gentleman with bilateral plantar fibromatosis caused by type 2 Diabetes Mellitus and previous alcohol excess. Results Treatment options include physiotherapy, steroid and collagenase injection therapy. Read More

Singapore Med J 2019 May;60(5):230-235

Department of Radiology, Sengkang General Hospital, Singapore.

A 46-year-old man presented with a six-month history of lumps in the sole of his left foot. Physical examination revealed two nodules, one tender and one firm, at the plantar left foot with no overlying skin changes. Although the initial radiographs were normal, magnetic resonance imaging of the left foot demonstrated two nodules along the medial band of the plantar fascia, characteristic of plantar fibromas. Read More

J Am Podiatr Med Assoc 2019 01;109(1):87-90

J Dtsch Dermatol Ges 2019 Apr 13;17(4):393-397. Epub 2019 Mar 13.

Department of Dermatology and Allergy Biederstein, Technical University of Munich, Munich, Germany.

Fibromatoses are a group of benign connective tissue tumors characterized by the infiltrative, aggressive proliferation of well-differentiated fibroblasts, leading to frequent local recurrence. Within this heterogeneous disease group, superficial fibromatoses show slower growth and more benign infiltration of surrounding tissues than deep fibromatoses. Superficial fibromatoses relevant to dermatology include palmar, plantar, and penile fibromatosis, knuckle pads, pachydermodactyly and infantile digital fibromatosis. Read More

Orthop Res Rev 2019 17;11:1-7. Epub 2018 Dec 17.

Albany Medical College Division of Orthopaedic Surgery, Albany, NY, USA,

Plantar fibromatosis (Ledderhose disease) is a rare, benign, hyperproliferative fibrous tissue disorder resulting in the formation of nodules along the plantar fascia. This condition can be locally aggressive, and often results in pain, functional disability, and decreased quality of life. Diagnosis is primarily clinical, but MRI and ultrasound are useful confirmatory adjuncts. Read More

Rom J Morphol Embryol 2018 ;59(3):691-697

Department of Anesthesiology and Intensive Care, Emergency Clinical Hospital of Bucharest, Romania;

Ledderhose disease or plantar fibromatosis is a rare hyperproliferative disorder of the plantar aponeurosis, clinically characterized by nodules situated especially on the medial border of the foot. It is histopathologically associated with Dupuytren's disease. This disease has some risk factors, like old age, alcohol or nicotine abuse, liver dysfunction, trauma or exposure to vibrations and autoimmune disorders, but the exact etiology is still unknown. Read More

Foot Ankle Surg 2019 Oct 11;25(5):559-564. Epub 2018 Jun 11.

Rizzoli Orthopaedic Institute, Bologna, Italy.

Background: Plantar fibromatosis, or Ledderhose disease, is a benign and hyperproliferative disease of the plantar aponeurosis. There have been described different therapeutic options regarding plantar fibromatosis, both conservative and surgical. The aim of this review is to systematically analyze conservative and operative treatments of plantar fibromatosis described in literature, evaluating which procedure shows the highest success rate and best functional outcome. Read More

Case Rep Rheumatol 2018 22;2018:3893846. Epub 2018 Apr 22.

Division of Plastic Surgery, Department of Surgery, Mayo Clinic Hospital, Phoenix, AZ, USA.

Polyfibromatosis is a rare disease characterized by fibrosis manifesting in different locations. It is commonly characterized by palmar fibromatosis (Dupuytren's contracture) in variable combinations with plantar fibromatosis (Ledderhose's disease), penile fibromatosis (Peyronie's disease), knuckle pads, and keloids. There are only three reported cases of polyfibromatosis and keloids with erosive arthritis. Read More

Foot Ankle Int 2018 06 5;39(6):751-757. Epub 2018 Apr 5.

3 University of Rochester Medical Center, Rochester, NY, USA.

J Ultrasound Med 2018 Nov 30;37(11):2725-2731. Epub 2018 Mar 30.

Department of Musculoskeletal Radiology, Mayo Clinic, Rochester, Minnesota, USA. Revision requested.

The purpose of this series is to review the appearance of plantar fibromatosis with high-resolution ultrasonography (US) and highlight a new imaging sign termed the "comb sign." A retrospective study was performed for patients with a clinical diagnosis of plantar fibromatosis. Charts of 43 patients (age range, 26-77 years; mean age, 54 years) were reviewed to gather patient demographics and symptoms. Read More

J Orthop Res 2018 09 23;36(9):2554-2561. Epub 2018 May 23.

Rothman Institute at Thomas Jefferson University, Philadelphia, Pennsylvania.

Although certainly not the first line treatment for plantar fibromas, surgical resection is a treatment option for some patients with have failed exhaustive non-surgical treatment. The use of topical Mitomycin C has been recently shown to reduce the recurrence rate of other fibrous lesions. The purpose of this study was to determine the impact of topical application of Mitomycin C on recurrence rate of plantar fibromas. Read More

Int J Sports Med 2018 Apr 13;39(4):314-321. Epub 2018 Mar 13.

Dept. Orthopaedic Surgery, Stanford University Medical Center, Stanford CA, USA.

Plantar fascial disorder is comprised of plantar fasciitis and plantar fibromatosis. Plantar fasciitis is the most common cause of heel pain, especially for athletes involved in running and jumping sports. Plantar fibromatosis is a rare fibrous hyperproliferation of the deep connective tissue of the foot. Read More

J Surg Orthop Adv 2017 WINTER;26(4):266-270

ProScan Imaging Education Foundation, Cincinnati, Ohio; Department of Radiology, University of Louisville, Louisville, Kentucky; Department of Radiology, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri; Department of Orthopedic Surgery, University of Cincinnati, Cincinnati, Ohio; Saint George Children's Hospital, Puerto Rico; and World Care Clinical Research, Boston, Massachusetts.

Plantar fibromatosis, also known as Ledderhose's disease, is a benign fibroblastic disorder of plantar aponeurosis, more specifically the medial side of the foot arch. Magnetic resonance imaging (MRI) has an important role in the diagnosis, staging, and determining the deep extension found in advanced, aggressive forms of plantar fibromatosis, thereby guiding appropriate clinical and surgical management. This case report aims to provide radiologists and clinicians with simple guidelines for the differential diagnosis of the fibroblastic and fibrohistiocytic soft tissue tumors of the foot with the emphasis on the MRI findings. Read More

Foot Ankle Spec 2018 Apr 9;11(2):168-176. Epub 2018 Jan 9.

Division of Podiatric Surgery, Center for Wound Healing, MedStar Georgetown University Hospital, Washington, DC (PC).

Plantar fibromatosis (morbus Ledderhose), an extra-abdominal desmoid tumor of the plantar foot, is a rare benign hyperproliferative disorder of the plantar fascia with an unknown etiology. The main clinical characteristics include slow growing nodules on the medial and central bands of the plantar fascia, which may become painful and negatively affect ambulation. Most established conservative therapies today target symptomatic relief. Read More

Skinmed 2017;15(6):480-482. Epub 2017 Dec 1.

Department of Dermatology, Goztepe Research and Training Hospital, Istanbul Medeniyet University, Istanbul, Turkey.

A 21-year-old mentally challenged man presented with a fixed plaque lesion on the right foot, which had been present for 10 years. Dermatologic examination revealed an erythematous, painful, firm, fixed plaque-nodular lesion on the plantar aspect of the right foot (Figure 1A). Nothing of distinction was noted from his family history or his laboratory tests. Read More

Int J Dermatol 2018 Mar 19;57(3):365-367. Epub 2017 Dec 19.

Dermatology Department, Faculty of Medicine of ABC, São Paulo, Brazil.

Background: Plantar fibromatosis or Ledderhose disease is characterized by a benign fibroblastic proliferation of the plantar fascia. It is an illness with unknown etiology and a complex treatment in its most intense manifestation.

Objective: The authors describe a surgical option for extensive cases where conservative treatments are not successful. Read More

Foot Ankle Surg 2017 Dec 5;23(4):e25-e30. Epub 2017 Apr 5.

Klinik für Orthopädie und Sportorthopädie, Klinikum rechts der Isar der Technischen Universität München, Ismaninger Str. 22, 81675 München, Germany; Wilhelm Sander-Therapieeinheitfür Knochen- und Weichteilsarkome am Klinikum rechts der Isar, Ismaninger Str. 22, 81675 München, Germany.

Plantar fibromatosis, also known as Morbus Ledderhose, is a well known and frequently encountered disorder of the planta pedis. When conservative treatment fails, surgical therapy with complete resection is the therapeutical procedure of choice. Soft tissue sarcoma is a heterogeneous and rare malignant disease of the musculoskeletal system with over 50 histopathological subtypes which can potentially arise in any localization but is most commonly found at the extremities. Read More

Cells 2017 Nov 1;6(4). Epub 2017 Nov 1.

Department of Biomedical Engineering and The Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California, Irvine, Irvine, CA 92697, USA.

Dupuytren's disease (palmar fibromatosis) involves nodules in fascia of the hand that leads to flexion contractures. Ledderhose disease (plantar fibromatosis) is similar with nodules of the foot. While clinical aspects are well-described, genetic mechanisms are unknown. Read More

Skeletal Radiol 2018 Feb 30;47(2):243-251. Epub 2017 Oct 30.

Department of Radiology, University of Miami Miller School of Medicine/Jackson Memorial Hospital, 1611 NW 12th Ave. JMH WW 279, Miami, FL, 33136, USA.

Objective: Electron beam therapy is a definitive radiation treatment option for superficial fibromatoses of the hands and feet. Because objective criteria for treatment response remain poorly defined, we sought to describe changes in electron beam treated lesions on MRI.

Materials And Methods: The study included 1 male and 9 female patients with a total of 37 superficial fibromatoses; average age was 60. Read More

Cardiovasc Intervent Radiol 2018 Feb 3;41(2):298-304. Epub 2017 Oct 3.

Department of Radiology, Yale Medical School, New Haven, CT, USA.

Purpose: Here, we report our experience in treating painful plantar fibromas with percutaneous cryoablation.

Methods: We retrospectively identified patients with symptomatic plantar fibromas who underwent percutaneous ultrasound-guided cryoablation between June 2014 and June 2015. In total, four patients (two male, two female) with five plantar fibromas undergoing a total of seven ablation procedures were identified. Read More

Surg J (N Y) 2016 Jul 21;2(3):e102-e104. Epub 2016 Sep 21.

Department of Plastic, Reconstructive, and Aesthetic Surgery, Selcuk University Medical Faculty, Konya, Turkey.

 Plantar fibromatosis is a rare hyperproliferative disease of plantar aponeurosis and is also called Ledderhose disease. Case properties and treatment are discussed in this report.  A 30-year-old man presented with painful bilateral plantar nodules. Read More

EFORT Open Rev 2017 May 11;2(5):261-271. Epub 2017 May 11.

Laboratoire d'anatomie et cytologie pathologiques, Institut Universitaire du Cancer de Toulouse- Oncopole, 1 avenue Irène Joliot-Curie. 31059 Toulouse Cedex 9, France.

Most of tumours of the foot are tumour-like (synovial cyst, foreign body reactions and epidermal inclusion cyst) or benign conditions (tenosynovial giant cells tumours, planta fibromatosis). Malignant tumours of the soft-tissue and skeleton are very rare in the foot and their diagnosis is often delayed with referral to specialised teams after initial inappropriate procedures or unplanned excisions. The adverse effect of these misdiagnosed tumours is the increasing rate of amputation or local recurrences in the involved patients. Read More

Foot (Edinb) 2017 Jun 21;31:31-34. Epub 2017 Feb 21.

Royal Liverpool and Broadgreen University Hospitals NHS Trust, Prescot Street, Liverpool, L7 8XP, United Kingdom.

Plantar fibromatosis is a rare, benign fibroproliferative disorder of the plantar fascia. It is considered as a low-grade tumour and it can be locally aggressive. It can present as painful swelling with impairment of local function. Read More

Arthrosc Tech 2016 Dec 5;5(6):e1387-e1393. Epub 2016 Dec 5.

Department of Orthopaedics and Traumatology, North District Hospital, Hong Kong SAR, China.

Plantar fibromatosis is a rare benign but often locally aggressive tumor of the plantar aponeurosis. Nonsurgical treatment is the first line of treatment for symptomatic lesions. Because of the high recurrence rate associated with surgical treatment, operation is indicated only when the lesions are highly symptomatic and conservative measures fail or the diagnosis is in question. Read More

J Clin Rheumatol 2017 Jan;23(1):63-65

Department of Physical and Rehabilitation Medicine, University of PadovaPadova, Italy.

Insights Imaging 2017 Feb 12;8(1):69-78. Epub 2016 Dec 12.

Radiology Department, Fondazione IRCCS Policlinico San Matteo, Università degli Studi di Pavia, Pavia, Italy.

Plantar fascia (PF) disorders commonly cause heel pain and disability in the general population. Imaging is often required to confirm diagnosis. This review article aims to provide simple and systematic guidelines for imaging assessment of PF disease, focussing on key findings detectable on plain radiography, ultrasound and magnetic resonance imaging (MRI). Read More

Am J Dermatopathol 2017 Mar;39(3):e38-e40

*Department of Medicine (DIMED), Surgical Pathology Unit, University of Padua, Padua, Italy; †Pathology Unit, Veneto Institute of Oncology, IOV-IRCCS, Padua, Italy; and ‡Clinic of Plastic Surgery, University of Padua, Padua, Italy.

Extraskeletal myxoid chondrosarcoma (EMC) is a rare soft tissue sarcoma usually presenting in proximal extremities of middle-aged men. The authors discuss a unique case of EMC, localized in the plantar foot of a 76-year-old woman, clinically suspected as plantar fibromatosis. It is important to avoid misdiagnosis of EMC because of their propensity for late recurrence and their metastatic potential. Read More

Acta Dermatovenerol Croat 2016 Jun;24(2):148-9

Aslı Aksu Çerman, MD, Şişli Hamidiye Etfal Training and Research Hospital, Dermatology Department, Halaskargazi Cad, Etfal S, Istanbul, Turkey;

Connective tissue nevi (CTN) are dermal hamartomas characterized by an imbalance in the amount and distribution of the normal components of the extracellular dermal matrix, specifically collagen, elastin, and/or proteoglicans. The term "CTN" was first mentioned by Lewandowsky in 1921 (1), although it was not accepted until the review by Gutmann in 1926 (2). Classification of CTN was established by Uitto et al. Read More

Joint Bone Spine 2017 05 17;84(3):371-372. Epub 2016 Jun 17.

Rheumatology Department, Clermont-Ferrand Teaching Hospital, place Henri-Dunant, 63000 Clermont-Ferrand, France.

Am J Phys Med Rehabil 2016 12;95(12):e204-e205

From the Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Bei-Hu Branch, and National Taiwan University College of Medicine, Taipei (K-VC); Department of Physical Medicine and Rehabilitation, China Medical University Hospital, Taichung (W-TW), Taiwan; and Department of Physical and Rehabilitation Medicine, Hacettepe University Medical School, Ankara, Turkey (LÖ).

Pain Med 2016 10 7;17(10):1965-1966. Epub 2016 Apr 7.

Department of Physical and Rehabilitation Medicine, Hacettepe University Medical School, Ankara, Turkey.

Case Rep Orthop 2015 10;2015:509732. Epub 2015 Dec 10.

Faculty of Medical Sciences and Health of Juiz de Fora (FCMS/JF - SUPREMA), BR 040, km 796, Salvaterra, 36045-410 Juiz de Fora, MG, Brazil; Hospital e Maternidade Therezinha de Jesus, Rua Doutor Dirceu de Andrade 33, São Mateus, 36025-140 Juiz de Fora, MG, Brazil.

Plantar fibromatosis, Ledderhose's disease, or Morbus Ledderhose is an uncommon benign nodular hyperplasia of the plantar aponeurosis. The aim of this paper was to report the case of a 47-year-old male patient who had concomitant Dupuytren's disease and failed all conservative measures. He was treated surgically with prompt and complete relief of symptoms postoperatively, and he has had no recurrence at the 2-year follow-up. Read More

Indian Dermatol Online J 2015 Nov-Dec;6(6):422-4

Ackerman Academy of Dermatopathology, New York, USA.

Ledderhose disease, or plantar fibromatosis, is a benign hyperproliferative disorder of the plantar aponeurosis. It presents as one or more round, firm slow-growing plaques or nodules on the plantar surface of the foot, typically on the medial side. The etiology is unknown, though it has been associated with trauma, liver disease, diabetes mellitus, epilepsy and alcoholism. Read More

J Orthop Sci 2016 May 29;21(3):395-8. Epub 2015 Jun 29.

Department of Orthopaedic Surgery, Teikyo University School of Medicine, 2-11-1, Kaga, Itabashi, Tokyo 173-8605, Japan.

Anticancer Res 2015 Nov;35(11):6171-4

Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, U.S.A.

Background: Extraskeletal myxoid chondrosarcoma is a rare tumor with an indolent course, high propensity for local recurrence, metastases, and propensity for the proximal extremities of middle-aged males.

Case Report: We present the case of a 44-year-old man with an extraskeletal myxoid chondrosarcoma in the plantar fascia of the medial arch initially thought to be a plantar fibroma. Magnetic resonance imaging of the lesion demonstrated a lobulated subcutaneous mass plantar to the tarsal bones and inseparable from the fascia. Read More

Case Rep Orthop 2015 6;2015:741461. Epub 2015 Sep 6.

Service d'Imagerie Médicale, CHU Saint-Pierre, 1000 Bruxelles, Belgium.

Plantar fibromatosis, or Ledderhose disease, is a rare hyperproliferative disorder of the plantar aponeurosis. It may occur at any age, with the greatest prevalence at middle age and beyond. This disorder is more common in men than woman and it is sometimes associated with other forms of fibromatosis. Read More

Pract Radiat Oncol 2015 Nov-Dec;5(6):e651-8. Epub 2015 Jul 2.

Department of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia.

Purpose: Palmar and plantar fibromatosis (PPF) is a progressive connective tissue disorder of the hand/foot that often leads to debilitating functional impairment. In Europe, orthovoltage radiation therapy (RT) has been demonstrated to prevent local disease progression for up to 80% of patients with early-stage PPF. There are limited data reporting outcomes for populations outside of Europe or using electron RT. Read More

J Eur Acad Dermatol Venereol 2016 Jul 24;30(7):1133-5. Epub 2015 Aug 24.

Department of Dermatology, Universitair Ziekenhuis Brussel, (UZ Brussel), Vrije Universiteit Brussel (VUB), Laarbeeklaan 101, Brussels, Belgium.

Background: The BRAF-inhibitor vemurafenib, used in patients with metastatic melanoma, induces multiple cutaneous side-effects.

Objective: The aim of this work was to evaluate the development of palmoplantar fibromatosis in a population of patients treated with the BRAF inhibitor vemurafenib.

Methods: Between April 2011 and February 2013, we initiated a treatment with vemurafenib in 53 patients with an unresectable stage IIIC or stage IV melanoma. Read More

Nucl Med Commun 2015 Sep;36(9):881-6

aDepartment of Radiology, Division of Nuclear Medicine, St Louis University bSaint Louis VA Medical Center, Saint Louis, Missouri, USA cNational Cancer Institute, Cairo University, Cairo, Egypt.

Plantar pain is a common problem endured by most adults at some point in their life that may result in considerable disability. Plantar fibromatosis is a locally invasive neoplasm, with the development of fibrous nodules on the plantar aspect of the feet, which can remain asymptomatic for years. (18)F-Fluorodeoxyglucose ((18)F-FDG) PET/CT has been more prevalent as the imaging modality of choice for cancer patients, but the imaged field of view is often from the base of the skull to the upper thighs. Read More

J Am Podiatr Med Assoc 2015 Mar;105(2):135-40

Background: One of the most common causes of heel pain is plantar fasciitis; however, there are other pathologic disorders that can mimic the symptoms and clinical presentation of this disorder. The purpose of this study was to retrospectively review the prevalence of various pathologic disorders on ultrasound in patients with proximal plantar heel pain.

Methods: The medical records and diagnostic ultrasound reports of patients presenting with plantar heel pain between March 1, 2006, and March 31, 2007, were reviewed retrospectively, and the prevalence of various etiologies was collected. Read More

Plast Reconstr Surg 2014 Sep;134(3):497e-498e

Department of Surgery, Wayne State University, 4201 St. Antoine, 6C-UHC, Detroit, Mich. 48201,

BMJ Case Rep 2014 Aug 14;2014. Epub 2014 Aug 14.

Centre for Clinical and Diagnsotic Oral Sciences, Institute of Dentistry, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

J Orthop Traumatol 2014 Sep 24;15(3):225-9. Epub 2014 Jun 24.

Patankar's Hand and Limb Reconstruction Clinic, 204, Garodia Market, Plot no. 8-A, D.K. Sandu Marg, Chembur, Mumbai, 400071, Maharashtra, India.

Background: Soft tissue defects over the mid- and distal third tibia, heel, dorsum and plantar aspect of the foot and over the medial, lateral and posterior aspect of the ankle are a common scenario in clinical orthopaedic practice. In this article, we describe the utility of the reverse sural fasciocutaneous flap with a cutaneous pedicle in 109 clinical cases with distal lower limb soft tissue defects.

Materials And Methods: A total of 109 patients were operated on for moderate (5-15 cm) and large (more than 15 cm) soft tissue defects at various sites along the lower limb including foot, heel and sole with the reverse sural fasciocutaneous flap. Read More

Pediatr Radiol 2014 Oct 13;44(10):1281-9. Epub 2014 May 13.

Hospital Universitaio y Politécnico La Fe, Valencia, Spain,

Background: Ablation techniques are widely used for solid malignant tumors in adults. There is no large series assessing the effectiveness of local ablative therapies in the treatment of malignant or aggressive benign lesions in children.

Objective: To review the existing evidence on the techniques and results of ablation for pediatric solid malignant or aggressive benign tumors. Read More