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J Am Podiatr Med Assoc 2022 Mar 16;112(1). Epub 2022 Mar 16.

*Town Center Foot Clinic, Happy Valley, OR.

Ledderhose disease (plantar fibromas) is histologically related to Dupuytren disease, which has been successfully treated for years with radiotherapy. Many conservative treatments have been advanced for plantar fibromas, including accommodative orthotic devices, which help but do not cure the disease. Surgery is considered the mainstay of treatment for this malady, but the failure rate has been as high as 100%, depending on the type of fasciectomy. Read More

Oncologist 2022 03;27(3):e294-e296

Department of Medicine, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY, USA.

Palmar and plantar fibromatosis are benign proliferative processes which present as a diffuse thickening or nodules of the hands and/or feet and may lead to flexion contractures, pain, and functional impairment known as Dupuytren and Ledderhose diseases, respectively. Current treatments are noncurative and associated with significant morbidity. Here, we report on the outcomes of 5 patients with advanced disease, no longer surgical candidates, treated with sorafenib. Read More

Radiother Oncol 2022 Mar 29;168:83-88. Epub 2022 Jan 29.

Department of Radiation Oncology, University Medical Centre Groningen, University of Groningen, The Netherlands. Electronic address:

Background: The purpose of this study was to investigate the long-term effects of radiotherapy for patients with Ledderhose disease.

Methods: Questionnaires were sent to all patients with Ledderhose disease who had been treated with radiotherapy at our centre between 2008 and 2017 and who consented to participate. Radiotherapy was performed with orthovolt or electrons in two separate courses of five daily fractions of 3 Gy. Read More

PLoS One 2021 24;16(11):e0259942. Epub 2021 Nov 24.

Graduate Institute of Biomedical Sciences, College of Medicine, China Medical University, Taichung, Taiwan.

Purpose: Infection, chronic pain and depression are considered risk factors for herpes zoster (HZ). However, the correlation between plantar fascial fibromatosis (PFF) and HZ remains unknown. This study investigated HZ risk in patients with PFF. Read More

Foot Ankle Spec 2021 Aug 8:19386400211032099. Epub 2021 Aug 8.

Department of Orthopaedic Surgery and Traumatology, Inselspital, University Hospital, University of Bern, Bern, Switzerland.

Background: The aim was to assess the recurrence rate and clinical outcome after wide resection for plantar fibromatosis.

Methods: A total of 12 patients, 2 to 13 years after wide resection, were assessed for local and magnetic resonance imaging tomographic signs of recurrence at the clinical follow-up. In addition, a systematic review of the literature was conducted. Read More

J Pathol Transl Med 2021 Jul 7;55(4):265-270. Epub 2021 Jul 7.

CWRU School of Medicine, University Hospitals, Bone and Soft Tissue Pathology, Cleveland, OH, USA.

Palmar fibromatosis (Dupuytren disease/contracture) is the most common type of fibromatosis, defined as a benign proliferation of fibroblasts and myofibroblasts. The disease process is most common in white, middle-aged and older men occurring at the distal palmar crease leading to nodules and contracture, which in many cases recur after surgical treatment. In a similar process, plantar fibromatosis (Ledderhose disease) is a proliferation of fibroblasts and myofibroblasts on the plantar aponeurosis of mostly middle-aged patients that may lead to painful nodules but usually does not lead to contracture. Read More

SAGE Open Med Case Rep 2021 28;9:2050313X211011813. Epub 2021 Apr 28.

Northamptonshire Healthcare NHS Foundation Trust, Daventry, UK.

The description of corticosteroid injections as a treatment option for Ledderhose disease has received little attention in the literature and often only receives a passing comment in scientific papers. We present a short case series of two patients who underwent corticosteroid injection in combination with fenestration to treat painful Ledderhose disease nodules. Both patients had their lesions injected on two occasions. Read More

J Surg Case Rep 2021 Feb 28;2021(2):rjaa501. Epub 2021 Feb 28.

Trauma and Orthopaedic Department, Broomfield Hospital, Chelmsford, UK.

Ledderhose disease is a connective tissue disorder involving proliferation of fibrous tissue in the plantar fascia of the foot. Histologically identical manifestations exist in the hand (Dupuytren's contracture) and penis (Peyronie's disease), and collagenase injections are approved as a treatment in both, however not in Ledderhose, where the treatment of choice remains surgical resection. Surgery is associated with high rates of recurrence and need for further surgery, so alternative therapies should be sought. Read More

Knee 2021 Mar 25;29:190-200. Epub 2021 Feb 25.

Department of Orthopedic Surgery, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USA. Electronic address:

Background: Total knee arthroplasty (TKA) is a successful treatment for patients with late stage osteoarthritis, yet arthrofibrosis remains a consistent cause of TKA failure. Dupuytren's, Ledderhose and Peyronie's Diseases are related conditions of increased fibroblast proliferation. The aim of this study was to identify whether an association exists between these conditions and arthrofibrosis following TKA. Read More

Foot (Edinb) 2021 Dec 8;49:101736. Epub 2020 Sep 8.

Aintree University Hospital, Lower Lane, Liverpool L9 7AL, United Kingdom. Electronic address:

Plantar fibromas are a common diagnosis in orthopaedic foot clinic consultation, diagnosis of plantar fibroma is usually from history and examination, and radiological investigation may be needed to confirm diagnosis. Misdiagnosis, however, of plantar fibroma have been known to happen. The management of five cases of plantar soft tissue swellings were reviewed; the clinical presentation and radiological investigation findings of these cases are discussed with the aim of improving knowledge and awareness. Read More

Radiologia (Engl Ed) 2020 Sep - Oct;62(5):415-416. Epub 2020 Aug 15.

Servicio de Dermatología y Venereología, Hospital Clínico Universitario Lozano Blesa, Zaragoza, España.

PLoS One 2020 10;15(8):e0237447. Epub 2020 Aug 10.

Department of Physical & Rehabilitation Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Background: Extracorporeal shock wave therapy (ESWT) has been used as a safe alternative treatment for refractory musculoskeletal diseases, such as plantar fasciitis, Achilles tendinopathy and gluteal tendinopathy, and various forms of fibromatosis including palmar or penile fibromatosis. However, there is limited published data for clinical and sonographic features of plantar fibromatosis after ESWT. The purpose of this study was to evaluate the long-term clinical outcome of ESWT in ultrasonography-confirmed plantar fibromatosis and ultrasonographic changes of plantar fibroma after ESWT. Read More

Foot Ankle Surg 2021 Jun 27;27(4):400-404. Epub 2020 May 27.

Singapore General Hospital, Academia, Level 4, Department of Orthopaedic Surgery, 20 College Road, 169865, Singapore. Electronic address:

Background: In evaluating foot and ankle soft tissue masses, comprehensive epidemiological data, especially clinical predictors of malignancy, is essential knowledge. Our aim was to assess these data in a cohort of patients that have undergone surgical excision of foot and ankle soft tissue tumours and pseudo-tumours over a 10-year period.

Methods: A retrospective review of foot and ankle soft tissue tumours and pseudo-tumours excised in a tertiary hospital from 1 Jan 2006 to 31 Dec 2016 was performed. Read More

Plast Reconstr Surg Glob Open 2020 Apr 27;8(4):e2754. Epub 2020 Apr 27.

Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italia.

Ledderhose disease (LD) is a rare plantar fibromatosis of the foot, frequently associated with Dupuytren disease. Collagenase of has recently revolutionized the way to treat Dupuytren disease. Nevertheless, the literature is still critically lacking about the use of collagenase injection in LD. Read More

Plast Reconstr Surg 2020 04;145(4):985-986

From the Section of Plastic Surgery, University of Calgary, Foothills Medical Centre; and the Section of Plastic Surgery, The University of Michigan Health System.

Plast Reconstr Surg 2020 04;145(4):978-984

From the Departments of Urology and Plastic and Reconstructive Surgery, University of Groningen and University Medical Center Groningen.

Background: Dupuytren, Peyronie, and Ledderhose diseases are related fibroproliferative disorders characterized by abnormalities in the connective tissue of the palm of the hand, the tunica albuginea of the penis, and the sole of the foot, respectively. Concomitant prevalence rates of these diseases have only been described in a few small populations. This article aims to report on a large population and to raise awareness in surgeons treating Dupuytren disease for concurring related fibroproliferative disorders. Read More

J Surg Case Rep 2020 Feb 28;2020(2):rjz402. Epub 2020 Feb 28.

Department of Plastic and Reconstructive Surgery, Shiga University of Medical Science, Otsu-city, Japan.

Plantar fibromatosis (PF) is a rare benign disease. Here we report bilateral PF accompanied by Dupuytren's contracture in the right palm. Magnetic resonance imaging was useful in diagnosing PF, although biopsy was needed to rule out hemangioma. Read More

J Foot Ankle Surg 2019 Nov;58(6):1281-1284

Pathologist, Crozer Keystone Health System, Upland, PA.

Plantar fibromatosis, also known as Ledderhose's disease, is a rare disorder of benign fibroblast proliferation involving the plantar aponeurosis (i.e., plantar fascia). Read More

J Orthop Case Rep 2019 ;9(2):84-86

Department of Orthopedics, Sri Ramachandra Medical College, Chennai, TamilNadu, India.

Introduction: Ledderhose's disease, also known asplantar fibromatosis, is a rare benign nodular hyperplasia of the plantar aponeurosis. The disease is locally aggressive and can be managed very well conservatively. In patients who present with severe pain on weight-bearing might require surgical excision. Read More

Neurologist 2019 Sep;24(5):150-151

Department of Neurology, Federal Hospital of Servidores do Estado, Rio de Janeiro-RJ, Brazil.

Introduction: Dupuytren, Ledderhose, and Peyronie diseases are chronic fibrotic conditions related to progressive fibrosis of the palmar fascia, plantar fascia, and tunica albuginea, respectively. These conditions have been associated with antiepileptic drug use, mainly phenobarbital and primidone.

Case Report: A 71-year-old man developed simultaneous Dupuytren, Ledderhose, and Peyronie diseases after primidone use for essential tremor. Read More

Ir Med J 2019 04 11;112(4):919. Epub 2019 Apr 11.

Mater Misericordiae University Hospital, Eccles Street, Dublin 7

Aim To describe an uncommon clinical finding and raise awareness of its manifestation and associated conditions. Methods This case describes a gentleman with bilateral plantar fibromatosis caused by type 2 Diabetes Mellitus and previous alcohol excess. Results Treatment options include physiotherapy, steroid and collagenase injection therapy. Read More

Singapore Med J 2019 May;60(5):230-235

Department of Radiology, Sengkang General Hospital, Singapore.

A 46-year-old man presented with a six-month history of lumps in the sole of his left foot. Physical examination revealed two nodules, one tender and one firm, at the plantar left foot with no overlying skin changes. Although the initial radiographs were normal, magnetic resonance imaging of the left foot demonstrated two nodules along the medial band of the plantar fascia, characteristic of plantar fibromas. Read More

J Am Podiatr Med Assoc 2019 01;109(1):87-90

J Dtsch Dermatol Ges 2019 Apr 13;17(4):393-397. Epub 2019 Mar 13.

Department of Dermatology and Allergy Biederstein, Technical University of Munich, Munich, Germany.

Fibromatoses are a group of benign connective tissue tumors characterized by the infiltrative, aggressive proliferation of well-differentiated fibroblasts, leading to frequent local recurrence. Within this heterogeneous disease group, superficial fibromatoses show slower growth and more benign infiltration of surrounding tissues than deep fibromatoses. Superficial fibromatoses relevant to dermatology include palmar, plantar, and penile fibromatosis, knuckle pads, pachydermodactyly and infantile digital fibromatosis. Read More

Orthop Res Rev 2019 17;11:1-7. Epub 2018 Dec 17.

Albany Medical College Division of Orthopaedic Surgery, Albany, NY, USA,

Plantar fibromatosis (Ledderhose disease) is a rare, benign, hyperproliferative fibrous tissue disorder resulting in the formation of nodules along the plantar fascia. This condition can be locally aggressive, and often results in pain, functional disability, and decreased quality of life. Diagnosis is primarily clinical, but MRI and ultrasound are useful confirmatory adjuncts. Read More

Ann Dermatol 2019 Feb 2;31(1):66-69. Epub 2019 Jan 2.

Department of Dermatology, Kangdong Sacred Heart Hospital, College of Medicine, Hallym University, Seoul, Korea.

Plantar vein thrombosis, rarely-reported disease, is usually accompanied by pain and tenderness in the plantar region and should be differentiated from other dermatological conditions causing plantar pain, such as hemorrhagic corn/callus, plantar epidermal cyst, verruca, or plantar fibromatosis. A 52-year-old man presented with a violaceous tender subcutaneous nodule overlying a hyperkeratotic plaque on his sole. Initially, he thought it was a corn and applied keratolytic agents, which failed to work. Read More

Rom J Morphol Embryol 2018 ;59(3):691-697

Department of Anesthesiology and Intensive Care, Emergency Clinical Hospital of Bucharest, Romania;

Ledderhose disease or plantar fibromatosis is a rare hyperproliferative disorder of the plantar aponeurosis, clinically characterized by nodules situated especially on the medial border of the foot. It is histopathologically associated with Dupuytren's disease. This disease has some risk factors, like old age, alcohol or nicotine abuse, liver dysfunction, trauma or exposure to vibrations and autoimmune disorders, but the exact etiology is still unknown. Read More

Foot Ankle Surg 2019 Oct 11;25(5):559-564. Epub 2018 Jun 11.

Rizzoli Orthopaedic Institute, Bologna, Italy.

Background: Plantar fibromatosis, or Ledderhose disease, is a benign and hyperproliferative disease of the plantar aponeurosis. There have been described different therapeutic options regarding plantar fibromatosis, both conservative and surgical. The aim of this review is to systematically analyze conservative and operative treatments of plantar fibromatosis described in literature, evaluating which procedure shows the highest success rate and best functional outcome. Read More

Case Rep Rheumatol 2018 22;2018:3893846. Epub 2018 Apr 22.

Division of Plastic Surgery, Department of Surgery, Mayo Clinic Hospital, Phoenix, AZ, USA.

Polyfibromatosis is a rare disease characterized by fibrosis manifesting in different locations. It is commonly characterized by palmar fibromatosis (Dupuytren's contracture) in variable combinations with plantar fibromatosis (Ledderhose's disease), penile fibromatosis (Peyronie's disease), knuckle pads, and keloids. There are only three reported cases of polyfibromatosis and keloids with erosive arthritis. Read More