28,037 results match your criteria Planta medica[Journal]


Functional Characterization of LIKE HETEROCHROMATIN PROTEIN 1 in the moss Physcomitrella patens: its conserved protein interactions in land plants.

Plant J 2018 Dec 7. Epub 2018 Dec 7.

University School of Biotechnology, Guru Gobind Singh Indraprastha University, Sector 16C, Dwarka, New, Delhi-110078, India.

In flowering plants LIKE HETEROCHROMATIN PROTEIN 1 (LHP1)/TERMINAL FLOWER 2 (TFL2) is known to interact with polycomb group (PcG) and non-PcG proteins and control developmental programs. LHP1/TFL2 is an ancient protein and has been characterized in the early-divergent plant Physcomitrella patens. However, interacting partners of PpLHP1 other than the chromomethylase PpCMT have not been identified to date. Read More

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December 2018

Phytophthora infestans effector SFI3 targets potato UBK to suppress early immune transcriptional responses.

New Phytol 2018 Dec 10. Epub 2018 Dec 10.

Division of Plant Science, School of Life Science, University of Dundee (at JHI), Invergowrie, Dundee, DD2 5DA, UK.

The potato blight agent Phytophthora infestans secretes a range of RXLR effectors to promote disease. Recent evidence indicates that some effectors suppress early pattern-triggered immunity (PTI) following perception of Microbe-Associated Molecular Patterns (MAMPs). Phytophthora infestans effector PiSFI3/Pi06087/PexRD16 was previously shown to suppress MAMP-triggered pFRK1-Luciferase reporter gene activity. Read More

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December 2018

Mortality of women with ductal carcinoma in situ of the breast: a population-based study from the Girona province, Spain (1994-2013).

Clin Transl Oncol 2018 Dec 10. Epub 2018 Dec 10.

Epidemiology Unit and Girona Cancer Registry, Oncology Coordination Plan, Department of Health, Autonomous Government of Catalonia, Catalan Institute of Oncology, Carrer del Sol, 15, 17004, Girona, Spain.

Purpose: We aim to comprehensively describe the incidence and mortality trends of ductal carcinoma in situ (DCIS) in the Girona province, Spain (1994-2013) and to estimate the all-cause mortality excess risk of diagnosed women.

Methods: Age-standardized rates of DCIS were estimated between 1994 and 2013. Standard mortality ratios (SMR) and absolute excess mortality were calculated overall and by tumor and patient characteristics. Read More

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December 2018

A lavender ABC transporter confers resistance to monoterpene toxicity in yeast.

Planta 2018 Dec 8. Epub 2018 Dec 8.

Department of Biology, University of British Columbia, Kelowna, BC, V1V 1V7, Canada.

Main Conclusion: Functional expression of a multidrug resistance-type ABC transporter from Lavandula angustifolia improved yeast resistance to geraniol, a monoterpene constituent of lavender essential oil. Plant ATP-binding cassette (ABC) transporters are a large family of membrane proteins involved in active and selective transport of structurally diverse compounds. In this study, we functionally evaluated LaABCB1, a multidrug resistance (MDR)-type ABC transporter strongly expressed in the secretory cells of lavender glandular trichomes, where monoterpene essential oil constituents are synthesized and secreted. Read More

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December 2018

Papillae formation on Arabidopsis leaf trichomes requires the function of Mediator tail subunits 2, 14, 15a, 16, and 25.

Planta 2018 Dec 7. Epub 2018 Dec 7.

School of Biological Sciences, Illinois State University, Normal, IL, 61790, USA.

Main Conclusion: Arabidopsis Mediator subunits 2, 14, 15a, 16, and 25 are required for papillae development on the trichome cell wall surface. Arabidopsis leaf hairs exhibit raised protrusions, termed papillae, on their cell wall surfaces. Here, we show that the glassy hair mutant, glh2, exhibits trichomes with an approximate 11-fold decrease in papillae density on their surfaces in comparison to wild type. Read More

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December 2018

Indole-3-acetylaspartate and indole-3-acetylglutamate, the IAA-amide conjugates in the diploid strawberry achene, are hydrolyzed in growing seedlings.

Planta 2018 Dec 8. Epub 2018 Dec 8.

USDA/ARS Genetic Improvement of Fruit and Vegetables Laboratory, 10300 Baltimore Avenue, Beltsville, MD, 20705, USA.

Main Conclusion: Indole-3-acetylaspartate and indole-3-acetylglutamate are the stored auxin amino acid conjugates of the achene of the diploid strawberry and serve as sources of auxin during seedling growth. The edible part of the strawberry, a pseudocarp, has long been known to enlarge in response to auxin produced by the developing achenes, the botanical true fruit. Auxin homeostasis involves a complex interaction between biosynthesis, conjugate formation and hydrolysis, catabolism and transport. Read More

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December 2018
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Predictive capability of the injury severity score versus the new injury severity score in the categorization of the severity of trauma patients: a cross-sectional observational study.

Eur J Trauma Emerg Surg 2018 Dec 8. Epub 2018 Dec 8.

University of Murcia, Faculty of Nursing. Edificio D, 3ª planta, despacho 20, Campus Universitario de Espinardo, 30100, Murcia, Murcia, Spain.

Purpose: The AIS scale is a measurement tool for single injuries. The ISS is considered the gold standard for determining the severity of injured patients, and the NISS was developed to improve the ISS with respect to loss of information, as well as to facilitate its calculation. The aim of this study was to analyse what injury severity measure, calculated according to the Abbreviated Injury Scale (AIS), 1998 and 2005 (update 2008) versions, performs better with mortality, cost and hospital length of stay healthcare indicators. Read More

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December 2018
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Evidence for rapid adaptive evolution of tolerance to chemical treatments in Phytophthora species and its practical implications.

PLoS One 2018 10;13(12):e0208961. Epub 2018 Dec 10.

Department of Environmental Science, Policy & Management, University of California, Berkeley, CA, United States of America.

Chemical treatments are used widely in agricultural and natural settings to protect plants from diseases; however, they may exert an important selection pressure on plant pathogens, promoting the development of tolerant isolates through adaptive evolution. Phosphite is used to manage diseases caused by Phytophthora species which include a large number of the most economically damaging plant pathogens worldwide. Phosphite controls the growth of Phytophthora species in planta without killing it; as a result, isolates can develop tolerance to phosphite after prolonged exposure. Read More

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December 2018

Paradigm changes for diagnosis: using big data for prediction.

Clin Chem Lab Med 2018 Dec 11. Epub 2018 Dec 11.

Hospital Clínic, IDIBAPS, Facultat de Medicina, Universitat de Barcelona, Barcelona, Catalunya, Spain.

Due to profound changes occurring in biomedical knowledge and in health systems worldwide, an entirely new health and social care scenario is emerging. Moreover, the enormous technological potential developed over the last years is increasingly influencing life sciences and driving changes toward personalized medicine and value-based healthcare. However, the current slow progression of adoption, limiting the generation of healthcare efficiencies through technological innovation, can be realistically overcome by fostering convergence between a systems medicine approach and the principles governing Integrated Care. Read More

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December 2018

Pharmacokinetics of Prenylflavonoids following Oral Ingestion of Standardized Epimedium Extract in Humans.

Planta Med 2018 Dec 6. Epub 2018 Dec 6.

Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Leaves of the plant are traditionally consumed for bone health and other indications. The aim of this study was to establish the safety and pharmacokinetics of the metabolites of prenylflavonoids (icariin, icariside I, icariside II, icaritin, and desmethylicaritin) following single doses of a defined prenylflavonoid extract in humans. A single oral dose of 370, 740, or 1110 mg of a standardized prenylflavonoid extract was administered to 30 healthy male subjects in a randomized, placebo-controlled trial. Read More

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December 2018
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2.152 Impact Factor

In Vitro Synthesis and Crystallization of β-1,4-Mannan.

Biomacromolecules 2018 Dec 6. Epub 2018 Dec 6.

In vitro polymerization of β-mannans is a challenging reaction due to the steric hindrance confered by the configuration of mannosyl residues and the thermodynamic instability of the β-anomer. Whatever the approach used to date - whether chemical, or enzymatic with glycosynthases and mannosyltransferases - pure β-1,4-mannans have never been synthesized in vitro. This has limited attempts to investigate their role in the production of plant and algal cell walls, in which they are highly abundant. Read More

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December 2018
1 Read

Erratum: Piper nigrum Oil - Determination of Selected Terpenes for Quality Evaluation.

Planta Med 2018 Dec 3. Epub 2018 Dec 3.

National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS, USA.

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December 2018
1 Read

Antioxidant capacity of Camellia japonica cultivars assessed by near- and mid-infrared spectroscopy.

Planta 2018 Dec 1. Epub 2018 Dec 1.

LAQV/REQUIMTE, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal.

Main Conclusion: Camellia japonica antioxidant capacity highly differs among its cultivars and could be successfully predicted by near- and mid-infrared spectroscopy. Camellia japonica is a Theaceae family species which are mainly used as an ornamental plant due to its colourful flowers presenting over than 32,000 recognized cultivars. However, this species have been somehow neglected due to the popular tea source, Camellia sinensis. Read More

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December 2018
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Probing the function of protein farnesyltransferase in Tripterygium wilfordii.

Plant Cell Rep 2018 Nov 30. Epub 2018 Nov 30.

School of Traditional Chinese Medicine, Capital Medical University, Beijing, 10069, China.

Key Message: We found two subunits FTase/GGTaseI-α and FTase-β formed a heterodimer to transfer a farnesyl group from FPP to protein N-dansyl-GCVLS, confirming they are responsible for protein farnesylation in planta. Tripterygium wilfordii is a medicinal plant with a broad spectrum of anti-inflammatory, immunosuppressive and anti-cancer activities. Recently, a number of studies have focused on investigating the biosynthetic pathways of its bioactive compounds, whereas little attention has been paid to the enzymes which play important roles in regulating diverse developmental processes of T. Read More

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November 2018
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GhNAC83 inhibits corm dormancy release by regulating ABA signaling and CK biosynthesis in Gladiolus hybridus.

J Exp Bot 2018 Dec 5. Epub 2018 Dec 5.

Beijing Key Laboratory of Development and Quality Control of Ornamental Crops, Department of Ornamental Horticulture and Landscape Architecture, China Agricultural University, Beijing, China.

Corm dormancy is an important trait for breeding in many bulb flowers, including the most cultivated Gladiolus hybridus. Gladiolus corms are modified underground stems that function as storage organs and remain dormant to survive adverse environmental conditions. Unlike seed dormancy, not much is known about corm dormancy. Read More

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December 2018
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The Petroleum Ether Extract from Hypericum perforatum Root Cultures Exhibits Potent Antiproliferative Activity in Human Keratinocytes and Fibroblasts.

Planta Med 2018 Dec 4. Epub 2018 Dec 4.

Institut für Pharmazeutische Technologie, Technische Universität Braunschweig, Germany.

The hyperforin content of herb was repeatedly reported to be responsible for a multitude of pharmacological activities. Our recent report about the hyperforin accumulation in root cultures of provides an alternative perspective to achieve constant product quality and to serve the rapidly growing market. In this study, the antiproliferative effect of a petroleum ether extract from the root cultures was investigated. Read More

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December 2018
6 Reads

Engineering Transport in Manganites by Tuning Local Nonstoichiometry in Grain Boundaries.

Adv Mater 2018 Dec 4:e1805360. Epub 2018 Dec 4.

Department of Advanced Materials for Energy, Catalonia Institute for Energy Research (IREC), Jardí de les Dones de Negre 1, Planta 2, 08930, Sant Adrià de Besòs (Barcelona), Spain.

Interface-dominated materials such as nanocrystalline thin films have emerged as an enthralling class of materials able to engineer functional properties of transition metal oxides widely used in energy and information technologies. In particular, it has been proven that strain-induced defects in grain boundaries of manganites deeply impact their functional properties by boosting their oxygen mass transport while abating their electronic and magnetic order. In this work, the origin of these dramatic changes is correlated for the first time with strong modifications of the anionic and cationic composition in the vicinity of strained grain boundary regions. Read More

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December 2018
5 Reads

Protein-Ligand Fishing for Biologically Active Natural Products Using Glutathione Transferases.

Front Plant Sci 2018 15;9:1659. Epub 2018 Nov 15.

Agriculture, School of Natural and Environmental Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom.

Screening for natural products which bind to proteins has been used to identify ligands of the plant-specific glutathione transferase (GST) tau (U) and phi (F) classes, that are present in large gene families in crops and weeds, but have largely undefined functions. When expressed as recombinant proteins in these proteins have been found to tightly bind a diverse range of natural product ligands, with fatty acid-and porphyrinogen-derivatives associated with GSTUs and a range of heterocyclic compounds with GSTFs. With an interest in detecting the natural binding partners of these proteins , we have expressed the two best characterized GSTs from (), GSTF2 and GSTU19, as -tagged fusion proteins Following transient and stable expression in Nicotiana and Arabidopsis, respectively, the GSTs were recovered using Strep-Tactin affinity chromatography and the bound ligands desorbed and characterized by LC-MS. Read More

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November 2018

Meshes in a mess: Mesenchymal stem cell-based therapies for soft tissue reinforcement.

Acta Biomater 2018 Nov 27. Epub 2018 Nov 27.

Stem Cell Therapy Unit, Jesús Usón Minimally Invasive Surgery Centre, Ctra. N-521, km 41.8, 10071 Cáceres, Spain; CIBER de Enfermedades Cardiovasculares, Avenida Monforte de Lemos, 3-5. Pabellón 11. Planta 0, 28029 Madrid, Spain.

Surgical meshes are frequently used for the treatment of abdominal hernias, pelvic organ prolapse, and stress urinary incontinence. Though these meshes are designed for tissue reinforcement, many complications have been reported. Both differentiated cell- and mesenchymal stem cell-based therapies have become attractive tools to improve their biocompatibility and tissue integration, minimizing adverse inflammatory reactions. Read More

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November 2018
4 Reads

Plasma-membrane electrical responses to salt and osmotic gradients contradict radiotracer kinetics, and reveal Na-transport dynamics in rice (Oryza sativa L.).

Planta 2018 Nov 29. Epub 2018 Nov 29.

School of Agriculture and Food, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Melbourne, VIC, 3010, Australia.

Main Conclusion: A systematic analysis of NaCl-dependent, plasma-membrane depolarization (∆∆Ψ) in rice roots calls into question the current leading model of rapid membrane cycling of Na under salt stress. To investigate the character and mechanisms of Na influx into roots, Na-dependent changes in plasma-membrane electrical potentials (∆∆Ψ) were measured in root cells of intact rice (Oryza sativa L., cv. Read More

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November 2018
4 Reads

Transcriptional and metabolic changes in the desiccation tolerant plant Craterostigma plantagineum during recurrent exposures to dehydration.

Planta 2018 Nov 29. Epub 2018 Nov 29.

Institute of Molecular Physiology and Biotechnology of Plants (IMBIO), University of Bonn, Kirschallee 1, 53115, Bonn, Germany.

Main Conclusion: Multiple dehydration/rehydration treatments improve the adaptation of Craterostigma plantagineum to desiccation by accumulating stress-inducible transcripts, proteins and metabolites. These molecules serve as stress imprints or memory and can lead to increased stress tolerance. It has been reported that repeated exposure to dehydration may generate stronger reactions during a subsequent dehydration treatment in plants. Read More

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November 2018
2 Reads

Production of a microbial emulsifier with biotechnological potential for environmental applications.

Colloids Surf B Biointerfaces 2018 Nov 22;174:459-466. Epub 2018 Nov 22.

Planta Piloto de Procesos Industriales Microbiológicos (PROIMI-CONICET), Avenida General Manuel Belgrano y Pasaje Caseros, T4001 MVB, Tucumán, Argentina. Electronic address:

The present work reports the production of bioemulsifiers (BEs) by an environmental bacterium closely related to Bacillus spp., using agro-industrial wastes and by-products as low-cost carbon sources. Maximum emulsifying activity was detected using crude glycerol (CG) (E = 59%), producing 2. Read More

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November 2018
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Negative effect of copper nanoparticles on the conjugation frequency of conjugative catabolic plasmids.

Ecotoxicol Environ Saf 2018 Nov 26;169:662-668. Epub 2018 Nov 26.

Departamento de Microbiología, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción, Chile. Electronic address:

Due to their antimicrobial properties, copper nanoparticles (CuNPs) have been proposed to be used in agriculture for pest control. Pesticides removal is mainly done by microorganisms, whose genes usually are found in conjugative catabolic plasmids (CCP). The aim of this work was to evaluate if CuNPs at subinhibitory concentrations modify the conjugation frequency (CF) of two CCP (pJP4 and pADP1). Read More

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November 2018
1 Read

ATR-FTIR spectroscopy non-destructively detects damage-induced sour rot infection in whole tomato fruit.

Planta 2018 Nov 28. Epub 2018 Nov 28.

School of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston, UK.

Main Conclusion: ATR-FTIR spectroscopy with subsequent multivariate analysis non-destructively identifies plant-pathogen interactions during disease progression, both directly and indirectly, through alterations in the spectral fingerprint. Plant-environment interactions are essential to understanding crop biology, optimizing crop use, and minimizing loss to ensure food security. Damage-induced pathogen infection of delicate fruit crops such as tomato (Solanum lycopersicum) are therefore important processes related to crop biology and modern horticulture. Read More

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November 2018
5 Reads

Genetic modification of western wheatgrass (Pascopyrum smithii) for the phytoremediation of RDX and TNT.

Planta 2018 Nov 28. Epub 2018 Nov 28.

Department of Civil and Environmental Engineering, University of Washington, Box 355014, Seattle, WA, 98195-5014, USA.

Main Conclusion: Transgenic western wheatgrass degrades the explosive RDX and detoxifies TNT. Contamination, from the explosives, hexahydro-1, 3, 5-trinitro-1, 3, 5-triazine (RDX), and 2, 4, 6-trinitrotoluene (TNT), especially on live-fire training ranges, threatens environmental and human health. Phytoremediation is an approach that could be used to clean-up explosive pollution, but it is hindered by inherently low in planta RDX degradation rates, and the high phytotoxicity of TNT. Read More

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November 2018

From the Outgoing Editor in Chief.

Planta Med 2018 Dec 28;84(18):1317. Epub 2018 Nov 28.

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December 2018

Photolyases and Cryptochromes in UV-resistant Bacteria from High-altitude Andean Lakes.

Photochem Photobiol 2018 Nov 28. Epub 2018 Nov 28.

Laboratorio de Investigaciones Microbiológicas de Lagunas Andinas (LIMLA), Planta Piloto de Procesos Industriales y Microbiológicos (PROIMI), CCT, CONICET, Tucumán, Argentina.

"High-Altitude Andean Lakes" (HAAL) are pristine environments harboring poly-extremophilic microbes that show combined adaptations to physical and chemical stress such as large daily ambient thermal amplitude, extreme solar radiation levels, intense dryness, alkalinity, high concentrations of arsenic (up to 200 ppm) and dissolved salts. In this work, we compared the UV resistance profiles, pigment content and photoreactivation abilities of three UV-resistant bacteria isolated from distinct niches from HAAL's: i.e. Read More

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November 2018

Potential of RNA interference in the study and management of the whitefly, Bemisia tabaci.

Arch Insect Biochem Physiol 2018 Nov 28:e21522. Epub 2018 Nov 28.

Department of Plants and Crops, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium.

Whiteflies cause considerable losses to crops, directly by feeding, and indirectly by transmission of viruses. The current control methods consist of a combination of different control tactics, mainly still relying on unsafe and non-ecofriendly chemical control. RNA interference (RNAi) is a post-transcriptional gene-silencing strategy in which double-stranded RNA (dsRNA), corresponding specifically to a target gene, is introduced in a target organism. Read More

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November 2018

Strategies for the Construction of Cassava Brown Streak Disease Viral Infectious Clones.

Mol Biotechnol 2018 Nov 27. Epub 2018 Nov 27.

School of Biological Sciences, University of Bristol, 24 Tyndall Ave, Bristol, BS8 1TQ, UK.

Cassava brown streak disease (CBSD) has major impacts on yield and quality of the tuberous roots of cassava in Eastern and Central Arica. At least two Potyviridae species cause the disease: Cassava brown streak virus (CBSV) and Ugandan cassava brown streak virus (UCBSV). Cloned viral genome sequences known as infectious clones (ICs) have been important in the study of other viruses, both as a means of standardising infectious material and characterising viral gene function. Read More

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November 2018
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Progressive programmed cell death inwards across the anther wall in male sterile flowers of the gynodioecious plant Plantago lanceolata.

Planta 2018 Nov 27. Epub 2018 Nov 27.

Department of Biology, Maynooth University, National University of Ireland Maynooth, Maynooth, Co. Kildare, Ireland.

Main Conclusion: A cell death signal is perceived and responded to by epidermal cells first before being conveyed inwards across the anther wall in male sterile Plantago lanceolata flowers. In gynodioecious plants, floral phenotype is determined by an interplay between cytoplasmic male sterility (CMS)-promoting factors and fertility-restoring genes segregating in the nuclear background. Plantago lanceolata exhibits at least four different sterilizing cytoplasms. Read More

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November 2018
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Mimosine accumulation in Leucaena leucocephala in response to stress signaling molecules and acute UV exposure.

Plant Physiol Biochem 2018 Nov 19. Epub 2018 Nov 19.

Plant Physiology Laboratory, Center for Biotechnology and Department of Botany, Federal University of Rio Grande do Sul (UFRGS), P.O. Box CP 15005, 91501-970, Porto Alegre, Rio Grande do Sul, Brazil. Electronic address:

Mimosine is a non-protein amino acid of Fabaceae, such as Leucaena spp. and Mimosa spp. Several relevant biological activities have been described for this molecule, including cell cycle blocker, anticancer, antifungal, antimicrobial, herbivore deterrent and allelopathic activities, raising increased economic interest in its production. Read More

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November 2018
2 Reads

The potential application of an autochthonous fungus from the northwest of Argentina for treatment of sugarcane vinasse.

J Hazard Mater 2018 Nov 17;365:820-826. Epub 2018 Nov 17.

Planta Piloto de Procesos Industriales Microbiológicos (PROIMI-CONICET), Av. Belgrano y Pje. Caseros, San Miguel de Tucumán, T4001MVB, Tucumán, Argentina. Electronic address:

Vinasse is a waste material from distillery industries, which causes major environmental problems around the world. Argentina alone produces about 4 billion liters of vinasse annually; consequently, diverse biological eco-friendly treatments are evaluated for their ability to reduce the detrimental effects. The present study reports on the degradation of a 50% (v/v) local vinasse sample by an autochthonous fungus identified as Aspergillus sp. Read More

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November 2018

Direct regulation of the EFR-dependent immune response by Arabidopsis TCP transcription factors.

Mol Plant Microbe Interact 2018 Nov 27. Epub 2018 Nov 27.

University of Missouri-Columbia, Plant Sciences, Columbia, Missouri, United States ;

One layer of the innate immune system allows plants to recognize pathogen-associated molecular patterns (PAMPS), activating a defense response known as PAMP-triggered immunity (PTI). Maintaining an active immune response, however, comes at the cost of plant growth and development; accordingly, optimization of the balance between defense and development is critical to plant fitness. The TCP transcription factor family consists of well-characterized transcriptional regulators of plant development and morphogenesis. Read More

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November 2018
4 Reads

Overexpression of geraniol synthase induces heat stress susceptibility in Nicotiana tabacum.

Planta 2018 Nov 26. Epub 2018 Nov 26.

Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, 6-3-1 Niijuku, Katsushika-ku, Tokyo, 125-8585, Japan.

Main Conclusion: Transgenic tobacco plants overexpressing the monoterpene alcohol geraniol synthase exhibit hypersensitivity to thermal stress, possibly due to suppressed sugar metabolism and transcriptional regulation of genes involved in thermal stress tolerance. Monoterpene alcohols function in plant survival strategies, but they may cause self-toxicity to plants due to their hydrophobic and highly reactive properties. To explore the role of these compounds in plant stress responses, we assessed transgenic tobacco plants overexpressing the monoterpene alcohol geraniol synthase (GES plants). Read More

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November 2018
2 Reads

Genetically encodable bioluminescent system from fungi.

Proc Natl Acad Sci U S A 2018 Dec 26;115(50):12728-12732. Epub 2018 Nov 26.

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia;

Bioluminescence is found across the entire tree of life, conferring a spectacular set of visually oriented functions from attracting mates to scaring off predators. Half a dozen different luciferins, molecules that emit light when enzymatically oxidized, are known. However, just one biochemical pathway for luciferin biosynthesis has been described in full, which is found only in bacteria. Read More

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December 2018
2 Reads

A Thioredoxin Domain-Containing Protein Interacts with Triple Gene Block Protein 1.

Int J Mol Sci 2018 Nov 25;19(12). Epub 2018 Nov 25.

Mediterranean Agronomic Institute of Chania, Department of Sustainable Agriculture, Alsylio Agrokepio, GR-73100 Chania, Greece.

(PepMV) is a mechanically-transmitted tomato pathogen of importance worldwide. Interactions between the PepMV coat protein and triple gene block protein (TGBp1) with the host heat shock cognate protein 70 and catalase 1 (CAT1), respectively, have been previously reported by our lab. In this study, a novel tomato interactor (TXND9) was shown to bind the PepMV TGBp1 in yeast-two-hybrid screening, in vitro pull-down and bimolecular fluorescent complementation (BiFC) assays. Read More

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November 2018
2 Reads

Fungal Endophytes Control and Reduce Trichothecenes and Zearalenone in Maize.

Toxins (Basel) 2018 Nov 24;10(12). Epub 2018 Nov 24.

Laboratory of Applied Mycology and Phenomics, Department of Plants and Crops, Faculty Bioscience Engineering, Ghent University, 9000 Ghent, Belgium.

can cause Giberella Ear Rot (GER) and seedling blight in maize, resulting in major yield losses. Besides GER, the infected grains are consequently contaminated with multiple mycotoxins of . Zearalenone and trichothecenes, such as deoxynivalenol and its acetylated forms, are among the major mycotoxins associated with infection in maize. Read More

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November 2018
6 Reads

Endocrine Disruptors and Autism Spectrum Disorder in Pregnancy: A Review and Evaluation of the Quality of the Epidemiological Evidence.

Children (Basel) 2018 Nov 23;5(12). Epub 2018 Nov 23.

Unit of Public Health and Environmental Care, Department of Preventive Medicine, University of Valencia, Avenida Vicente Andrés Estellés s/n, Burjasot, 46100 Valencia, Spain.

Exposure to environmental contaminants during pregnancy has been linked to adverse health outcomes later in life. Notable among these pollutants are the endocrine disruptors chemicals (EDCs), which are ubiquitously present in the environment and they have been measured and quantified in the fetus. In this systematic review, our objective was to summarize the epidemiological research on the potential association between prenatal exposure to EDCs and Autism Spectrum Disorder (ASD) published from 2005 to 2016. Read More

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November 2018
5 Reads

A Review of Plants Used in South African Traditional Medicine for the Management and Treatment of Hypertension.

Planta Med 2018 Nov 26. Epub 2018 Nov 26.

Phytomedicine and phytopharmacology Research Group, Department of Plant Sciences, University of the Free State, QwaQwa Campus, South Africa.

South Africa contains 9% of the world's higher plants, and despite its rich biodiversity, it has one of the highest prevalence of hypertension in Africa. This review provides information on medicinal plants embraced in South Africa for hypertension management, with the aim of reporting pharmacological information on the indigenous use of these plants as antihypertensives. This review not only focuses on the activity of antihypertensive medicinal plants but also reports some of its phytochemical constituents and other ethnopharmacological and therapeutic properties. Read More

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November 2018

A combinatorial approach to study cytochrome P450 enzymes for de novo production of steviol glucosides in baker's yeast.

ACS Synth Biol 2018 Nov 26. Epub 2018 Nov 26.

Biosynthesis of steviol glycosides in planta proceeds via two cytochrome P450 enzymes (CYPs): kaurene oxidase (KO) and kaurenoic acid hydroxylase (KAH). KO and KAH function in succession with the support of a NADPH-dependent cytochrome P450 reductase (CPR) to convert kaurene to steviol. This work describes a platform for recombinant production of steviol glucosides (SGs) in Saccharomyces cerevisiae, demonstrating the full reconstituted pathway from the simple sugar glucose to the SG precursor steviol. Read More

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November 2018
2 Reads

Flax rhamnogalacturonan lyases: phylogeny, differential expression, and modeling of protein structure.

Physiol Plant 2018 Nov 25. Epub 2018 Nov 25.

Kazan Institute of Biochemistry and Biophysics, Federal Research Center "Kazan Scientific Center of RAS", 420111, Lobachevsky Str., 2/31 Kazan, Russian Federation.

Rhamnogalacturonan lyases (RGLs; EC 4.2.2. Read More

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November 2018
1 Read

Cyanobacterial Catalase Activity Prevents Oxidative Stress Induced by Pseudomonas fluorescens DUS1-27 from Inhibiting Brassica napus L. (canola) Growth.

Microbes Environ 2018 Nov 23. Epub 2018 Nov 23.

Deakin University, Geelong, Australia, Centre for Regional and Rural Futures, School of Life and Environmental Sciences.

Plant growth-promoting bacteria (PGPB) inhabit the rhizosphere of plants and are capable of enhancing plant growth through a number of mechanisms. A strain of Pseudomonas fluorescens DUS1-27 was identified as a potential PGPB candidate based on its ability to increase the growth of Brassica napus L. (canola) over that of uninoculated control plants in a soil-based system. Read More

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November 2018

Monkeyflowers (Mimulus): new model for plant developmental genetics and evo-devo.

Authors:
Yao-Wu Yuan

New Phytol 2018 Nov 24. Epub 2018 Nov 24.

Department of Ecology and Evolutionary Biology, University of Connecticut, Storrs, CT, 06269, USA.

Contents Summary I. Introduction II. The system III. Read More

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November 2018
6 Reads

Performance, feed utilization, and hepatic metabolic response of weaned juvenile Atlantic bluefin tuna (Thunnus thynnus L.): effects of dietary lipid level and source.

Fish Physiol Biochem 2018 Nov 23. Epub 2018 Nov 23.

Departamento de Biología, Facultad de Ciencias del Mar y Ambientales, Universidad de Cádiz, 11510 Puerto Real, Cádiz, Spain.

Two trials were performed using extruded diets as on-growing feeds for weaned Atlantic bluefin tuna (Thunnus thynnus; ABT) to establish adequate dietary levels of both lipid and omega-3 long-chain polyunsaturated fatty acids (LC-PUFAs), and impacts on lipid metabolism via liver gene expression. In trial A, ABT were fed with either a commercial feed (Magokoro®; MGK) as a reference diet or two experimental feeds differing in lipid levels (15 or 20%) using krill oil (KO) as the single lipid source in order to estimate suitable lipid content. Fish fed MGK displayed the highest growth, followed by 15KO, and therefore a dietary lipid content of 15% was considered preferable to 20% at this stage. Read More

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November 2018
1 Read

Engineering modular diterpene biosynthetic pathways in Physcomitrella patens.

Planta 2018 Nov 23. Epub 2018 Nov 23.

Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, 48824, USA.

Main Conclusion: Modular assembly and heterologous expression in the moss Physcomitrella patens of pairs of diterpene synthases results in accumulation of modern land plant diterpenoids. Physcomitrella patens is a representative of the ancient bryophyte plant lineage with a genome size of 511 Mb, dominant haploid life cycle and limited chemical and metabolic complexity. For these plants, exceptional capacity for genome editing through homologous recombination is met with recently demonstrated in vivo assembly of multiple heterologous DNA fragments. Read More

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November 2018
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A hypothesis about the origin of carotenoid lipid droplets in the green algae Dunaliella and Haematococcus.

Planta 2018 Nov 23. Epub 2018 Nov 23.

Department of Chemistry and Biochemistry, University of California, Los Angeles, CA, 90095-1569, USA.

Main Conclusion: Hypercarotenogenesis in green algae evolved by mutation of PSY that increased its transcription at high light, disintegration of the eyespot in Dunaliella and acquisition of the capacity to export carotenoids from chloroplasts in Haematococcus. Carotenoids (Car) are lipid-soluble pigments synthesized in plants, algae, bacteria and fungi. Car have strong antioxidative properties and as such are utilized to reduce the danger of different diseases in humans. Read More

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November 2018
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Baicalin Induces Apoptotic Death of Human Chondrosarcoma Cells through Mitochondrial Dysfunction and Downregulation of the PI3K/Akt/mTOR Pathway.

Planta Med 2018 Nov 23. Epub 2018 Nov 23.

Department of Spine Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

The aim of the present study was to investigate the cytotoxic and antitumour effects of baicalin in human chondrosarcoma both and . We examined the effects of baicalin on the growth and apoptosis of human chondrosarcoma cells. Baicalin inhibited the growth of SW1353 and CH2879 cells in a dose- and time-dependent manner, but did not inhibit the growth of normal chondrocytes. Read More

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November 2018
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Isoprenyl diphosphate synthases: the chain length determining step in terpene biosynthesis.

Planta 2018 Nov 22. Epub 2018 Nov 22.

Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA, 50011, USA.

Main Conclusion: This review summarizes the recent developments in the study of isoprenyl diphosphate synthases with an emphasis on analytical techniques, product length determination, and the physiological consequences of manipulating expression in planta. The highly diverse structures of all terpenes are synthesized from the five carbon precursors dimethylallyl diphosphate and a varying number of isopentenyl diphosphate units through 1'-4 alkylation reactions. These elongation reactions are catalyzed by isoprenyl diphosphate synthases (IDS). Read More

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November 2018
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Terpenes and isoprenoids: a wealth of compounds for global use.

Authors:
Sarada D Tetali

Planta 2018 Nov 22. Epub 2018 Nov 22.

Department of Plant Sciences, School of Life Sciences, University of Hyderabad, C. R. Prof. CR Rao Rd., CUC, Gachibowli, Hyderabad, 500046, Telangana, India.

Main Conclusion: Role of terpenes and isoprenoids has been pivotal in the survival and evolution of higher plants in various ecoregions. These products find application in the pharmaceutical, flavor fragrance, and biofuel industries. Fitness of plants in a wide range of environmental conditions entailed (i) evolution of secondary metabolic pathways enabling utilization of photosynthate for the synthesis of a variety of biomolecules, thereby facilitating diverse eco-interactive functions, and (ii) evolution of structural features for the sequestration of such compounds away from the mainstream primary metabolism to prevent autotoxicity. Read More

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November 2018
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From plant physiology to pharmacology: fusicoccin leaves the leaves.

Planta 2018 Nov 22. Epub 2018 Nov 22.

Department of Biology, University of Rome Tor Vergata, via della Ricerca Scientifica, 00133, Rome, Italy.

Main Conclusion: This review highlights 50 years of research on the fungal diterpene fusicoccin, during which the molecule went from a tool in plant physiology research to a pharmacological agent in treating animal diseases. Fusicoccin is a phytotoxic glycosylated diterpene produced by the fungus Phomopsis amygdali, a pathogen of almond and peach plants. Widespread interest in this molecule started when it was discovered that it is capable of causing stomate opening in all higher plants, thereby inducing wilting of leaves. Read More

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November 2018
6 Reads