9,888 results match your criteria Planta medica[Journal]


Pharmacokinetics and Tissue Distribution of Aegeline after Oral Administration in Mice.

Planta Med 2019 Feb 12. Epub 2019 Feb 12.

National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS, USA.

Aegeline is claimed to be a biologically active constituent of . Preclinical studies have reported possible therapeutic potential for aegeline against obesity and diabetes. In recent years, aegeline has been added to several weight loss products. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0851-6879DOI Listing
February 2019
1 Read

Brazilian Plants: An Unexplored Source of Endophytes as Producers of Active Metabolites.

Planta Med 2019 Feb 11. Epub 2019 Feb 11.

Federal University of Paraná, Department of Genetics, Curitiba, Brazil.

Brazil has an extraordinary biodiversity, and for many years, has been classified as the first of 17 countries with a mega diversity, with 22% of the total plants in the world (more than 55 000 species). Considering that some endophytes are host-specific, the incomparable plant diversity found in Brazil encompasses an immeasurable variety of habitats and may represent a repository of unexplored species. As a result of the endophyte-host interaction, plant-associated microorganisms have an enormous biosynthetic potential to produce compounds with novelties in structure and bioactivity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0847-1532DOI Listing
February 2019
1 Read

Metabolism of Scoparone in Experimental Animals and Humans.

Planta Med 2019 Feb 8. Epub 2019 Feb 8.

School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.

Scoparone, a major constituent of the Chinese herbal medicine Yin Chen Hao, expresses beneficial effects in experimental models of various diseases. The intrinsic doses and effects of scoparone are dependent on its metabolism, both in humans and animals. We evaluated in detail the metabolism of scoparone in human, mouse, rat, pig, dog, and rabbit liver microsomes and in humans . Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0835-2301DOI Listing
February 2019

Icariin Attenuates High Glucose-Induced Apoptosis, Oxidative Stress, and Inflammation in Human Umbilical Venous Endothelial Cells.

Planta Med 2019 Jan 31. Epub 2019 Jan 31.

Department of Pathology & Pathophysiology, Wuhan University School of Basic Medical Sciences, Wuhan, China.

Endothelial dysfunction is closely associated with diabetic complications. Icariin, a flavonoid glycoside isolated from the plant species, exhibits antidiabetic properties. However, its impact on endothelial function remains poorly understood, particularly under hyperglycemia. Read More

View Article

Download full-text PDF

Source
http://www.thieme-connect.de/DOI/DOI?10.1055/a-0837-0975
Publisher Site
http://dx.doi.org/10.1055/a-0837-0975DOI Listing
January 2019
3 Reads

Safety and Pharmacokinetics of Standardized Extract of Centella asiatica (ECa 233) Capsules in Healthy Thai Volunteers: A Phase 1 Clinical Study.

Planta Med 2019 Jan 30. Epub 2019 Jan 30.

Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.

The aim of this study was to investigate the safety and pharmacokinetic profiles of a newly developed, standardized extract of (ECa 233) capsule in healthy Thai volunteers. This study was designed as an open-labeled, 2-sequence dosage, single- and repeated-dose study investigated under fasting conditions. Plasma concentrations of the parent compounds and their relative acid metabolites were measured and pharmacokinetic parameters were calculated using noncompartmental analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0835-6671DOI Listing
January 2019
6 Reads
2.152 Impact Factor

Induction of Secondary Metabolites from the Marine-Derived Fungus Aspergillus versicolor through Co-cultivation with Bacillus subtilis.

Planta Med 2019 Jan 30. Epub 2019 Jan 30.

Institut für Pharmazeutische Biologie und Biotechnologie, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany.

A new cyclic pentapeptide, cotteslosin C (1: ), a new aflaquinolone, 22-epi-aflaquinolone B (3: ), and two new anthraquinones (9: and 10: ), along with thirty known compounds (2, 4:  - 8, 11:  - 34: ) were isolated from a co-culture of the sponge-associated fungus with . The new metabolites were only detected in the co-culture extract, but not when the fungus was grown under axenic conditions. Furthermore, the co-culture extract exhibited an enhanced accumulation of the known constituents versicolorin B (14: ), averufin (16: ), and sterigmatocyctin (19: ) by factors of 1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0835-2332DOI Listing
January 2019
1 Read

α-Tetralonyl Glucosides from the Green Walnut Husks of Juglans mandshurica and Their Antiproliferative Effects.

Planta Med 2019 Jan 28. Epub 2019 Jan 28.

School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.

Two new -tetralonyl glucosides, (4)-4,5,8-trihydroxy--tetralone-5---D-glucopyranosyl(1 → 6)--D-glucopyranoside (1: ) and (4)-4,8-dihydroxy--tetralone-4---D-glucopyranosyl(1 → 6)--D-glucopyranoside (2: ), together with eight known compounds (3:  - 10: ) were isolated from the green walnut husks of . The structural characterization of all compounds was performed by spectroscopic analyses, including 1D and 2D NMR and HR-ESI-MS experiments. The isolated compounds were assayed for their cytotoxicity against two human cancer cell lines, A549 and HeLa. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0832-2328DOI Listing
January 2019
1 Read

Anti-Inflammatory Effect of a Novel Topical Herbal Composition (VEL-091604) Consisting of Gentian Root, Licorice Root and Willow Bark Extract.

Planta Med 2019 Jan 28. Epub 2019 Jan 28.

Research Center skinitial, Department of Dermatology, Medical Center, University of Freiburg, Freiburg, Germany.

The anti-inflammatory properties of the topical herbal composition VEL-091604 with gentian root, licorice root, and willow bark extract were assessed in a randomized, prospective, placebo-controlled, double-blind ultraviolet (UV)-erythema test study with 42 healthy volunteers in comparison to 1% hydrocortisone acetate. The efficacy and tolerability of VEL-091604 cream 2 times daily over 2 wk was evaluated in an open-label, prospective proof of concept study in 10 subjects with atopic dermatitis using a lesional SCORAD severity score. In the UV-erythema test VEL-091604 cream significantly reduced inflammation compared to placebo and was as effective as 1% hydrocortisone acetate. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0835-6806DOI Listing
January 2019
1 Read

Effects of Sideritis scardica Extract on Glucose Tolerance, Triglyceride Levels and Markers of Oxidative Stress in Ovariectomized Rats.

Planta Med 2019 Jan 28. Epub 2019 Jan 28.

Institute of Biochemistry, School of Medicine, University of Belgrade, Belgrade, Serbia.

Menopause is characterized by deep metabolic disturbances, including decreased insulin sensitivity, adiposity, and changes in lipid profiles. Estrogen replacement therapy can partially reverse these changes, and while it is safe in most healthy postmenopausal women, there are still existing concerns regarding an increased risk for breast and endometrial cancer as well as a risk for cardiovascular and thromboembolic disease. Therefore, certain natural compounds with positive metabolic effects may be considered as a possible alternative or adjunctive treatment in patients not willing to take estrogens or patients with contraindications for estrogens. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0835-6622DOI Listing
January 2019
2 Reads

Editorial.

Planta Med 2019 Jan 22;85(2):93. Epub 2019 Jan 22.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0819-4096DOI Listing
January 2019
2 Reads

Natural Product Triterpenoids and Their Semi-Synthetic Derivatives with Potential Anticancer Activity.

Planta Med 2019 Jan 18. Epub 2019 Jan 18.

Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio, United States.

Triterpenoids are distributed widely in higher plants and are of interest because of their structural diversity and broad range of bioactivities. In particular, there is a very large literature on the propensity of a variety of triterpenoids to act as potential anticancer agents. In the present review, the anticancer potential is summarized for naturally occurring triterpenoids and their semi-synthetic derivatives, including examples of lupane-, oleanane-, ursane-, and cucurbitane-type pentacyclic triterpenoids, along with dammarane-type tetracyclic triterpenes including ginsenosides and their sapogenins and dichapetalins, which have been characterized as antitumor leads from higher plants. Read More

View Article

Download full-text PDF

Source
http://www.thieme-connect.de/DOI/DOI?10.1055/a-0832-2383
Publisher Site
http://dx.doi.org/10.1055/a-0832-2383DOI Listing
January 2019
4 Reads

Cytotoxic Prenylated Xanthones from the Leaves of Garcinia bracteata.

Planta Med 2019 Jan 16. Epub 2019 Jan 16.

School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.

Six new prenylated xanthones (1: -6: ) and seventeen known xanthones were isolated from extracts of leaves. Their structures were determined by extensive NMR and MS spectroscopic data analysis. The inhibitory activities of the isolates were assayed on HeLa, A549, PC-3, HT-29, and WPMY-1 cell lines. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0828-9831DOI Listing
January 2019
8 Reads

Triterpenoids from Hibiscus sabdariffa L. with PPARδ/γ Dual Agonist Action: In Vivo, In Vitro and In Silico Studies.

Planta Med 2019 Jan 16. Epub 2019 Jan 16.

Laboratorio de Farmacología, Departamento de Ciencias de la Salud, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, Ciudad de México, México.

is a medicinal plant consumed as a diuretic and anti-obesity remedy. Several pharmacological studies have shown its beneficial effects in metabolism. Peroxisome proliferator-activated receptors and may play a role in the actions of These nuclear receptors regulate lipid and glucose metabolism and are therapeutic targets for type 2 diabetes. Read More

View Article

Download full-text PDF

Source
http://www.thieme-connect.de/DOI/DOI?10.1055/a-0824-1316
Publisher Site
http://dx.doi.org/10.1055/a-0824-1316DOI Listing
January 2019
7 Reads
2.152 Impact Factor

Analysis of Terpenes in Cannabis sativa L. Using GC/MS: Method Development, Validation, and Application.

Planta Med 2019 Jan 15. Epub 2019 Jan 15.

National Center for Natural Products Research, University of Mississippi, University, MS, USA.

Terpenes are the major components of the essential oils present in various L. varieties. These compounds are responsible for the distinctive aromas and flavors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0828-8387DOI Listing
January 2019
13 Reads

Antiprotozoal Germacranolide Sesquiterpene Lactones from Tanacetum sonbolii.

Planta Med 2019 Jan 8. Epub 2019 Jan 8.

Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G. C., Evin, Tehran, Iran.

A phytochemical investigation of extracts from flowers and aerial parts of afforded 7 new germacranolide sesquiterpene lactones. The structures were established by a combination of 1- and 2-dimensional nuclear magnetic resonance spectroscopy, high-resolution mass spectrometry, and electronic circular dichroism. The antiprotozoal activity of the compounds against and cytotoxicity against rat myoblast (L6) cells were determined. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0824-1294DOI Listing
January 2019
4 Reads

Catalpol Ameliorates Neointimal Hyperplasia in Diabetic Rats.

Planta Med 2019 Jan 4. Epub 2019 Jan 4.

Department of Emergency Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.

Catalpol, an iridoid glycoside, is an isolated natural product of , which has been reported to have antidiabetic properties. This study investigated the vascular protective effects of catalpol in hyperglycemic rats with balloon-injured carotid arteries. Balloon injury stress led to the upregulation of monocyte chemoattractant protein-1 expression in rats with streptozotocin-induced diabetes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0818-3689DOI Listing
January 2019
3 Reads

Inhibitory Effects of Pterocarpus santalinus Extract against IgE/Antigen-Sensitized Mast Cells and Atopic Dermatitis-Like Skin Lesions.

Planta Med 2019 Jan 4. Epub 2019 Jan 4.

Graduate School of Energy and Environment, Korea University, Seoul, South Korea.

has been traditionally used as a medicinal plant owing to its anti-inflammatory, anthelmintic, tonic, antihyperglycemic, and diaphoretic properties. We hypothesized that might have therapeutic potential in alleviating allergy and atopic dermatitis. Thus, we investigated the inhibitory effects of extract against allergic responses and 2,4-dinitrochlorobenzene-induced atopic dermatitis-like dorsal skin lesions using immunoglobulin E-sensitized rat basophilic leukemia-2H3 mast cells and NC/Nga mice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0824-1282DOI Listing
January 2019
6 Reads

Editorial.

Planta Med 2019 Jan 3;85(1). Epub 2019 Jan 3.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0774-4019DOI Listing
January 2019
2 Reads

Inhibitory Effect of Damulin B from Gynostemma pentaphyllum on Human Lung Cancer Cells.

Planta Med 2018 Dec 18. Epub 2018 Dec 18.

School of Pharmacy, Minzu University of China, Beijing, China.

Damulin B, a dammarane-type saponin from steamed , exhibits the strongest activity against human lung carcinoma A549 cells among the isolated active saponins. In this study, the structure-activity relationship of a series of saponin compounds was discussed. The inhibitory effect of damulin B on human lung cancer A549 and H1299 cells was investigated from apoptosis, cell cycle, and migration aspects. Read More

View Article

Download full-text PDF

Source
http://www.thieme-connect.de/DOI/DOI?10.1055/a-0810-7738
Publisher Site
http://dx.doi.org/10.1055/a-0810-7738DOI Listing
December 2018
5 Reads

A Bufadienolide-Enriched Fraction of Bryophyllum pinnatum Inhibits Human Myometrial Contractility In Vitro.

Planta Med 2018 Dec 18. Epub 2018 Dec 18.

Department of Obstetrics, University Hospital Zurich, Zurich, Switzerland.

has been used since the 1970s to prevent premature labour, first in anthroposophic hospitals and, more recently, also in the main Swiss perinatal centres. However, it is not known which compounds in leaves contribute to the tocolytic effect. Here we studied the effects of a flavonoid-enriched fraction, the corresponding flavonoid aglycon mixture, a bufadienolide-enriched fraction, and leaf press juice on human myometrial contractility . Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0810-7704DOI Listing
December 2018
2 Reads

Pharmacokinetics of Prenylflavonoids following Oral Ingestion of Standardized Epimedium Extract in Humans.

Planta Med 2018 Dec 6. Epub 2018 Dec 6.

Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Leaves of the plant are traditionally consumed for bone health and other indications. The aim of this study was to establish the safety and pharmacokinetics of the metabolites of prenylflavonoids (icariin, icariside I, icariside II, icaritin, and desmethylicaritin) following single doses of a defined prenylflavonoid extract in humans. A single oral dose of 370, 740, or 1110 mg of a standardized prenylflavonoid extract was administered to 30 healthy male subjects in a randomized, placebo-controlled trial. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0806-7673DOI Listing
December 2018
8 Reads
2.152 Impact Factor

Erratum: Piper nigrum Oil - Determination of Selected Terpenes for Quality Evaluation.

Planta Med 2018 Dec 3. Epub 2018 Dec 3.

National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0808-3238DOI Listing
December 2018
6 Reads

The Petroleum Ether Extract from Hypericum perforatum Root Cultures Exhibits Potent Antiproliferative Activity in Human Keratinocytes and Fibroblasts.

Planta Med 2018 Dec 4. Epub 2018 Dec 4.

Institut für Pharmazeutische Technologie, Technische Universität Braunschweig, Germany.

The hyperforin content of herb was repeatedly reported to be responsible for a multitude of pharmacological activities. Our recent report about the hyperforin accumulation in root cultures of provides an alternative perspective to achieve constant product quality and to serve the rapidly growing market. In this study, the antiproliferative effect of a petroleum ether extract from the root cultures was investigated. Read More

View Article

Download full-text PDF

Source
http://www.thieme-connect.de/DOI/DOI?10.1055/a-0806-7735
Publisher Site
http://dx.doi.org/10.1055/a-0806-7735DOI Listing
December 2018
13 Reads

From the Outgoing Editor in Chief.

Planta Med 2018 Dec 28;84(18):1317. Epub 2018 Nov 28.

View Article

Download full-text PDF

Source
http://www.thieme-connect.de/DOI/DOI?10.1055/a-0766-8081
Publisher Site
http://dx.doi.org/10.1055/a-0766-8081DOI Listing
December 2018
4 Reads

A Review of Plants Used in South African Traditional Medicine for the Management and Treatment of Hypertension.

Planta Med 2018 Nov 26. Epub 2018 Nov 26.

Phytomedicine and phytopharmacology Research Group, Department of Plant Sciences, University of the Free State, QwaQwa Campus, South Africa.

South Africa contains 9% of the world's higher plants, and despite its rich biodiversity, it has one of the highest prevalence of hypertension in Africa. This review provides information on medicinal plants embraced in South Africa for hypertension management, with the aim of reporting pharmacological information on the indigenous use of these plants as antihypertensives. This review not only focuses on the activity of antihypertensive medicinal plants but also reports some of its phytochemical constituents and other ethnopharmacological and therapeutic properties. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0801-8771DOI Listing
November 2018
1 Read

Baicalin Induces Apoptotic Death of Human Chondrosarcoma Cells through Mitochondrial Dysfunction and Downregulation of the PI3K/Akt/mTOR Pathway.

Planta Med 2018 Nov 23. Epub 2018 Nov 23.

Department of Spine Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

The aim of the present study was to investigate the cytotoxic and antitumour effects of baicalin in human chondrosarcoma both and . We examined the effects of baicalin on the growth and apoptosis of human chondrosarcoma cells. Baicalin inhibited the growth of SW1353 and CH2879 cells in a dose- and time-dependent manner, but did not inhibit the growth of normal chondrocytes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0791-1049DOI Listing
November 2018
7 Reads

Anti-inflammatory and Quinone Reductase-Inducing Compounds from Beilschmiedia mannii.

Planta Med 2018 Nov 22. Epub 2018 Nov 22.

School of pharmaceutical sciences, University of Geneva, University of Lausanne, Geneva, Switzerland.

Previous studies on the therapeutic potential of plant species found in the diet of chimpanzees living in Taï National Park have shown that they could be potential candidates for the search of new molecules useful for humans. Based on the screening of some of these plants, the fruits of , whose dichloromethane extract showed cancer chemopreventive properties, were selected. Bioactivity-guided fractionation of the extract resulted in the isolation and identification of two -pyrones, including desmethoxydihydromethysticin (1: ), found in a natural source for the first time, and a new congener, beilschmiediapyrone (2: ), as well as five known alkamides (3:  - 7: ). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0798-3155DOI Listing
November 2018
13 Reads
2.152 Impact Factor

Cucurbitacin B Induces Hypermethylation of Oncogenes in Breast Cancer Cells.

Planta Med 2018 Nov 21. Epub 2018 Nov 21.

Department of Clinical Microscopy, Faculty of Medical Technology, Mahidol University, Nakhon Pathom, Thailand.

Breast cancer is a complex disease driven by multiple factors including both genetic and epigenetic alterations. Recent studies revealed that abnormal gene expression induced by epigenetic changes including aberrant promoter methylation plays a critical role in human breast carcinogenesis. Cucurbitacin B has antiproliferative activity against various human breast cancer cells, but the molecular mechanism is not completely understood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0791-1591DOI Listing
November 2018
7 Reads

Anti-Inflammatory Activity of Lobaric Acid via Suppressing NF-κB/MAPK Pathways or NLRP3 Inflammasome Activation.

Planta Med 2018 Nov 16. Epub 2018 Nov 16.

School of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea.

Lobaric acid (LA) is a constituent of the lichen . LA has multiple biological activities, including antibacterial and antioxidant ones. The purpose of this study was to investigate the effect of LA and its mechanism on lipopolysaccharide (LPS)-induced inflammatory responses in macrophages. Read More

View Article

Download full-text PDF

Source
http://www.thieme-connect.de/DOI/DOI?10.1055/a-0777-2420
Publisher Site
http://dx.doi.org/10.1055/a-0777-2420DOI Listing
November 2018
8 Reads

Comparative Pharmacokinetics of Mitragynine after Oral Administration of Mitragyna speciosa (Kratom) Leaf Extracts in Rats.

Planta Med 2018 Nov 16. Epub 2018 Nov 16.

Department of BioMolecular Sciences, School of Pharmacy, The University of Mississippi, University, MS, USA.

Kratom () has been examined for its opioid activity, especially for the treatment of opioid withdrawal and pain. Mitragynine, the most abundant alkaloid in kratom, is thought to be the major psychoactive alkaloid. An HPLC method was developed for the quantification of mitragynine in kratom leaf extracts. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0770-3683DOI Listing
November 2018
3 Reads

Piper nigrum Oil - Determination of Selected Terpenes for Quality Evaluation.

Planta Med 2019 Feb 15;85(3):185-194. Epub 2018 Nov 15.

National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS, USA.

The growing demand and commercial value of black pepper () has resulted in considerable interest in developing suitable and cost-effective methods for chemical characterization and quality evaluation purposes. In the current study, an extensive set of oil samples (n = 23) that were extracted by steam distillation from black pepper seeds was investigated to compare the chemical profiles of samples originating from nine major producing countries, as well as to identify potential chemical markers for quality evaluation. The twenty-two most abundant volatile compounds, mainly terpenes, in these oils were determined by conventional GC/MS analysis. Read More

View Article

Download full-text PDF

Source
http://www.thieme-connect.de/DOI/DOI?10.1055/a-0782-0548
Publisher Site
http://dx.doi.org/10.1055/a-0782-0548DOI Listing
February 2019
13 Reads

Synthesis and In Vitro Anti-inflammatory Activity of C20 Epimeric Ocotillol-Type Triterpenes and Protopanaxadiol.

Planta Med 2018 Oct 31. Epub 2018 Oct 31.

School of Pharmacy, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Yantai University, Yantai, P. R. China.

Ginseng is a perennial herb that contains various medicinal substances. The major active constituents of ginseng are ginsenosides, which have multifarious biological activities. Some pharmacological activities are closely dependent on the stereoisomers derived from the configuration at C20. Read More

View Article

Download full-text PDF

Source
http://www.thieme-connect.de/DOI/DOI?10.1055/a-0770-0994
Publisher Site
http://dx.doi.org/10.1055/a-0770-0994DOI Listing
October 2018
4 Reads

Characterization of Casearin X Metabolism by Rat and Human Liver Microsomes.

Planta Med 2018 Oct 29. Epub 2018 Oct 29.

Departamento de Química, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.

Casearin X (CAS X) is the major clerodane diterpene isolated from the leaves of and has been extensively studied due to its powerful cytotoxic activity at low concentrations. Promising results for antitumor action have also been described when CAS X was administered intraperitoneally in mice. Conversely, loss of activity was observed when orally administered. Read More

View Article

Download full-text PDF

Source
http://www.thieme-connect.de/DOI/DOI?10.1055/a-0765-9523
Publisher Site
http://dx.doi.org/10.1055/a-0765-9523DOI Listing
October 2018
10 Reads

Essential Oils as Treatment Strategy for Alzheimer's Disease: Current and Future Perspectives.

Planta Med 2019 Feb 25;85(3):239-248. Epub 2018 Oct 25.

Department of Pharmacology, Amrita School of Pharmacy, Amrita University, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, India.

Alzheimer's disease is a multifarious neurodegenerative disease that causes cognitive impairment and gradual memory loss. Several hypotheses have been put forward to postulate its pathophysiology. Currently, few drugs are available for the management of Alzheimer's disease and the treatment provides only symptomatic relief. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0758-0188DOI Listing
February 2019
36 Reads

PPARα and γ Activation Effects of New Nor-triterpenoidal Saponins from the Aerial Parts of Anabasis articulata.

Planta Med 2018 Oct 25. Epub 2018 Oct 25.

National Center for Natural Products Research, School of Pharmacy, University of Mississippi, Oxford, Mississippi, USA.

, traditionally used to treat diabetes, is rich in saponin content. This study was performed to investigate the agonistic effect of its saponins on peroxisome proliferator-activated receptor- and peroxisome proliferator-activated receptor- in human hepatoma (HepG2) cells to explore the possibility of the involvement of these nuclear receptors in the mechanism of the antidiabetic effect of the plant. Chemical investigation of the -butanol fraction resulted in the isolation of three new and one known 30-noroleanane triterpenoid saponins. Read More

View Article

Download full-text PDF

Source
http://www.thieme-connect.de/DOI/DOI?10.1055/a-0762-0885
Publisher Site
http://dx.doi.org/10.1055/a-0762-0885DOI Listing
October 2018
9 Reads

Increased Oral Bioavailability of Piperine from an Optimized Piper nigrum Nanosuspension.

Planta Med 2019 Feb 24;85(3):249-257. Epub 2018 Oct 24.

Department of Chemistry, University of Agriculture, Faisalabad, Pakistan.

The aim of the present study was to enhance the pharmaceutical potential and oral bioavailability of piperine, which is the bioactive constituent of , using the nanosuspension approach. Nanoprecipitation, which is a simple and reproducible process, was used for nanosuspension formulation. To prepare a pharmaceutical-grade nanosuspension with the required particle size, important formulation parameters (amount of plant extract, concentration of stabilizer, and antisolvent-to-solvent ratio) were optimized using the central composite design of response surface methodology. Read More

View Article

Download full-text PDF

Source
http://www.thieme-connect.de/DOI/DOI?10.1055/a-0759-2208
Publisher Site
http://dx.doi.org/10.1055/a-0759-2208DOI Listing
February 2019
7 Reads

The Activity of Urolithin A and M4 Valerolactone, Colonic Microbiota Metabolites of Polyphenols, in a Prostate Cancer In Vitro Model.

Planta Med 2019 Jan 19;85(2):118-125. Epub 2018 Oct 19.

Department of Pharmacognosy and Molecular Basis of Phytotherapy, Faculty of Pharmacy, Medical University of Warsaw, Warsaw, Poland.

The gut microbiota-derived metabolites of ellagitannins and green tea catechins, urolithin A (uroA) and 5-(3',4',5'-trihydroxyphenyl)--valerolactone (M4), respectively, are among the main compounds absorbed into human system after ingestion of these polyphenols. The aim of this study was to establish the effects of M4, uroA, and their combinations on LNCaP cells, an androgen dependent prostate cancer model.. Read More

View Article

Download full-text PDF

Source
http://www.thieme-connect.de/DOI/DOI?10.1055/a-0755-7715
Publisher Site
http://dx.doi.org/10.1055/a-0755-7715DOI Listing
January 2019
13 Reads

Fighting Liver Fibrosis with Naturally Occurring Antioxidants.

Planta Med 2018 Dec 12;84(18):1318-1333. Epub 2018 Oct 12.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medicine Sciences, University of Macau, Macau, China.

Liver fibrosis is a wound-healing response characterized by the accumulation of extracellular matrix following various liver injuries, which results in the deformation of the normal liver architecture and the development of liver cirrhosis and even hepatocellular carcinoma. Numerous and studies indicated that oxidative stress mediates the initiation and progression of liver fibrosis. Overaccumulation of reactive oxygen species disrupts macromolecules, induces necrosis and apoptosis of hepatocytes, stimulates the production of pro-fibrogenic mediators, and directly activates hepatic stellate cells, thereby resulting in liver damage and initiating liver fibrosis. Read More

View Article

Download full-text PDF

Source
http://www.thieme-connect.de/DOI/DOI?10.1055/a-0757-0008
Publisher Site
http://dx.doi.org/10.1055/a-0757-0008DOI Listing
December 2018
13 Reads

Influence of Cranberry Extract on Tamm-Horsfall Protein in Human Urine and its Antiadhesive Activity Against Uropathogenic Escherichia coli.

Planta Med 2019 Jan 12;85(2):126-138. Epub 2018 Oct 12.

University of Münster, Institute of Pharmaceutical Biology and Phytochemistry, Münster, Germany.

LC-MS characterized cranberry extract from the fruits of Vaccinium macrocarpon inhibited under in vitro conditions the bacterial adhesion of strain 2980 uropathogenic (UPEC strains UTI89, NU14) to T24 bladder cells and adhesion of UPEC strain CFT073 to A498 kidney cells in a concentration-dependent manner. Within a biomedical study, urine samples from 16 volunteers (8 male, 8 female) consuming cranberry extract for 7 d (900 mg/d) were analyzed for potential antiadhesive activity against UPEC by ex vivo experiments. Results indicated inhibition of adhesion of UPEC strain UTI89 to human T24 bladder cells. Read More

View Article

Download full-text PDF

Source
http://www.thieme-connect.de/DOI/DOI?10.1055/a-0755-7801
Publisher Site
http://dx.doi.org/10.1055/a-0755-7801DOI Listing
January 2019
4 Reads

Pharmacological Properties of Geraniol - A Review.

Planta Med 2019 Jan 11;85(1):48-55. Epub 2018 Oct 11.

School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Geraniol is an acyclic isoprenoid monoterpene isolated from the essential oils of aromatic plants including , and several other plants. The limited source of geraniol from plant isolation cannot fulfill the great demand from the flavor and fragrance industries, which require maximizing geraniol production through biotechnology processes. The diverse activities of geraniol suggested that geraniol could treat various diseases as a promising drug candidate. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0750-6907DOI Listing
January 2019
4 Reads

Icariin Improves Functional Behavior in a Mouse Model of Traumatic Brain Injury and Promotes Synaptic Plasticity Markers.

Planta Med 2019 Feb 9;85(3):231-238. Epub 2018 Oct 9.

Department of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University, Seoul, Korea.

Epimedii Herba (EH) has been used in traditional Asian medicine to treat hemiplegia following stroke. Icariin, its major active component, is used as a quality-control marker and for its various pharmacological effects. We hypothesized that icariin would show protective effects following traumatic brain injury (TBI). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0753-0400DOI Listing
February 2019
10 Reads

Infraspecific Variation of Huperzine A and B in Icelandic Huperzia selago Complex.

Planta Med 2019 Jan 5;85(2):160-168. Epub 2018 Oct 5.

Faculty of Pharmaceutical Sciences, University of Iceland, Reykjavik, Iceland.

The alkaloids huperzine A and huperzine B were originally isolated from the Chinese club moss . They are known inhibitors of acetylcholinesterase, and especially huperzine A shows pharmaceutical potential for the treatment of Alzheimer's disease. Its supply heavily relies on natural plant sources belonging to the genus , which shows considerable interspecific huperzine A variations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0752-0295DOI Listing
January 2019
2 Reads

α-Glucosidase Inhibitory and Anti-Inflammatory Coumestans from the Roots of Dolichos trilobus.

Planta Med 2019 Jan 2;85(2):112-117. Epub 2018 Oct 2.

Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, Yunnan, P. R. China.

Four new coumestans dolichosins A - D (1: -4: ) were isolated from the roots of , together with four known compounds: isosojagol (5: ), phaseol (6: ), psoralidin (7: ), and 4″,5″-dehydroisopsoralidin (8: ). Their structures were elucidated on the basis of spectroscopic data interpretation, mass spectrometric analyses, and the comparison with literature data of related compounds. The anti-inflammatory activity of these compounds (1: -8: ) was evaluated through the inhibition of nitric oxide production in lipopolysaccharide-activated murine macrophage RAW 264. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0746-8622DOI Listing
January 2019
1 Read

Stellera chamaejasme and Its Main Compound Luteolin 7-O-Glucoside Alleviates Skin Lesions in Oxazolone- and 2,4-Dinitrochlorobenzene-Stimulated Murine Models of Atopic Dermatitis.

Planta Med 2018 Oct 1. Epub 2018 Oct 1.

College of Pharmacy, Pusan National University, Busan, Republic of Korea.

, also known as "", has been traditionally used for the management of skin-related diseases such as psoriasis and skin ulcers. The aim of this study was to determine whether and its major component, luteolin 7--glucoside, have a preventive effect on the development of atopic dermatitis in oxazolone-treated BALB/c mice and 2,4-dinitrochlorobenzene-treated hairless mice. The epicutaneous applications of oxazolone and 2,4-dinitrochlorobenzene evoke an experimental murine atopic dermatitis-like reaction in BALB/c mouse ears and SKH-1 hairless mice. Read More

View Article

Download full-text PDF

Source
http://www.thieme-connect.de/DOI/DOI?10.1055/a-0746-8698
Publisher Site
http://dx.doi.org/10.1055/a-0746-8698DOI Listing
October 2018
14 Reads

Isoflavones from Camphorosma lessingii Inhibit the Organic Anion Transporters OAT1 and OAT3.

Planta Med 2019 Feb 24;85(3):225-230. Epub 2018 Sep 24.

School of Pharmaceutical Science and Technology, Health Sciences Platform, Tianjin University, Tianjin, China.

Phytochemical investigation of has resulted in the isolation of four previously unreported isoflavones (1: -4: ) and eight known compounds (5: -12: ). Nine of these compounds (1: -6, 8: -10: ) are reported for the first time from members of the family Amaranthaceae. The structures of all isolated compounds were determined by spectroscopic methods, primarily one-dimensional and two-dimensional nuclear magnetic resonance and mass spectrometry. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0740-3255DOI Listing
February 2019
7 Reads

Serine Protease Mauritanicain from Euphorbia mauritanica and Phorbol-12-myristate-13-acetate Modulate the IL-8 Release in Fibroblasts and HaCaT Keratinocytes.

Planta Med 2018 Sep 24. Epub 2018 Sep 24.

Freie Universitaet Berlin, Institute of Pharmacy, Department of Pharmaceutical Biology, Berlin, Germany.

In recent years, skin reactions such as phytophotodermatitis, contact dermatitis, and other inflammatory responses after contact with chemicals from various plants, e.g., or , are one of the hot topics in phytobiology. Read More

View Article

Download full-text PDF

Source
http://www.thieme-connect.de/DOI/DOI?10.1055/a-0735-9911
Publisher Site
http://dx.doi.org/10.1055/a-0735-9911DOI Listing
September 2018
19 Reads

Pro-Fibrogenic and Anti-Inflammatory Potential of a Polyphenol-Enriched Fraction from Annona crassiflora in Skin Repair.

Planta Med 2018 Sep 20. Epub 2018 Sep 20.

Institute of Biomedical Sciences, Federal University of Uberlândia, Uberlandia, MG, Brazil.

A polyphenol-enriched fraction from fruit peel (PEF-Ac) containing chlorogenic acid, epi-catechin, procyanidins B2 and C1, quercetin-glucoside, kaempferol, and caffeoyl-glucoside was investigated for its anti-inflammatory, pro-angiogenic, and profibrogenic potential in the healing of cutaneous wounds. Four wounds were performed on the back of C57 mice and the lesions were treated with the vehicle (Vaseline and lanolin) and PEF-Ac at concentrations of 2%, 4%, and 6% for 4 and 7 d. Neutrophils and macrophages activities were evaluated indirectly by the activity of myeloperoxidase and N-acetyl--D-glycosaminidase, angiogenesis was evaluated by hemoglobin dosing and vessel count in histological sections, and collagen deposition was assessed from histological sections stained with picrosirius red. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0733-7151DOI Listing
September 2018
3 Reads

New Cytotoxic Cycloartane Triterpenes from the Aerial Parts of Actaea heracleifolia (syn. Cimicifuga heracleifolia).

Planta Med 2019 Jan 19;85(2):154-159. Epub 2018 Sep 19.

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming, China.

One new 15,16-seco-cycloartane triterpene (1: ), three new cycloartane triterpene glycosides (2: -4: ), and five known compounds (5: -9: ) were isolated from the aerial parts of The chemical structures of these compounds were determined on the basis of NMR analysis, HRTOF-ESIMS data, and other spectroscopic methods. Selected compounds were evaluated for their cytotoxicity against human tumor cell lines (HL-60, SMMC-7721, A549, MCF-7, and SW480) . Compounds 3: and 4: showed weak activity against the HL-60, A-549, and MCF-7 cell lines with IC values ranging from 21. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0733-7229DOI Listing
January 2019
3 Reads
2.152 Impact Factor

Direct-Injection Electron Ionization-Mass Spectrometry Metabolomics Method for Analyzing Blueberry Leaf Metabolites That Inhibit Adult T-cell Leukemia Proliferation.

Planta Med 2019 Jan 13;85(1):81-87. Epub 2018 Sep 13.

Department of Pharmaceutical Health Sciences, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare, Nobeoka, Japan.

Metabolic profiling is often used to identify possible correlations between a compound's metabolic profile and biological activity. Direct-injection electron ionization-mass spectrometry "fingerprinting" is useful for characterizing biological materials. We demonstrate the utility of direct-injection electron ionization-mass spectrometry for metabolic profiling using 100 different extracts of leaves from 20 blueberry cultivars collected at 5 time points from April to December 2008. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0725-8295DOI Listing
January 2019
3 Reads

Nanotechnological Approach to Increase the Antioxidant and Cytotoxic Efficacy of Crocin and Crocetin.

Planta Med 2019 Feb 11;85(3):258-265. Epub 2018 Sep 11.

Department of Drug Sciences, University of Catania, Catania, Italy.

Crocin and crocetin are two interesting constituents of saffron () that possess important biological activities. Their use as therapeutic agents is strongly compromised by a scarce stability, poor absorption, and low bioavailability. Therefore, to improve these unfavorable features, the aim of the present work has been to apply a nanotechnological approach based on the formulation of solid lipid nanoparticles containing crocin and crocetin. Read More

View Article

Download full-text PDF

Source
http://www.thieme-connect.de/DOI/DOI?10.1055/a-0732-5757
Publisher Site
http://dx.doi.org/10.1055/a-0732-5757DOI Listing
February 2019
14 Reads