9,908 results match your criteria Planta medica[Journal]


Quercus ilex Extract Ameliorates Acute TNBS-Induced Colitis in Rats.

Planta Med 2019 Apr 24. Epub 2019 Apr 24.

Department of Pharmacology, Faculty of Pharmacy, University of Seville, Seville, Spain.

L. (Fagaceae) is one of the most commonly used plants in folk medicine in the Mediterranean region to treat gastrointestinal disorders. The aim of the present study was to evaluate the effects of a polyphenol extract from mature leaves of on acute 2,4,6-trinitrobenzene sulfonic acid-induced colitis in rats. Read More

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http://dx.doi.org/10.1055/a-0889-6132DOI Listing

Effects of Enantiomerically Pure β-Carboline Alkaloids from Picrasma quassioides on Human Hepatoma Cells.

Planta Med 2019 Apr 11. Epub 2019 Apr 11.

School of Traditional Chinese Materia Medica, Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.

Four pairs of -carboline enantiomers (1A: /1B: -4A: /4B: ), 2 -carboline derivatives (5:  - 6: ) with a single enantiomeric configuration, together with 2 known achiral congeners (7:  - 8: ) were isolated from the stems of Their structures were elucidated on the basis of extensive spectroscopic analyses and quantum mechanical calculations. Compound 5: possesses a 4,5-seco -carboline framework and represents the first example of this type of -carboline alkaloids from nature. A possible biosynthetic pathway is proposed to generate the racemate 4: and the enantiomerically pure compounds 5: and 6: . Read More

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http://dx.doi.org/10.1055/a-0879-4721DOI Listing

Antiangiogenic Iridoids from Stachys ocymastrum and Premna resinosa.

Planta Med 2019 Apr 9. Epub 2019 Apr 9.

Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche e Ambientali, Università degli Studi di Messina, Messina, Italy.

In this paper, the isolation of one new iridoid glucoside, 6-acetoxyipolamiide (1: ), and thirteen (2:  - 14: ) known congeners from two Lamiaceae species, and , leaf extracts is reported. The structural determination of the isolated compounds was performed by mono- and bidimensional NMR spectroscopic analysis as well as MS experiments. The isolates were assayed for their antiangiogenic activity by two models, zebrafish embryos and chick chorioallantoic membrane assays. Read More

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http://dx.doi.org/10.1055/a-0889-0412DOI Listing
April 2019
2 Reads

O-Methyl Phytocannabinoids: Semi-synthesis, Analysis in Cannabis Flowerheads, and Biological Activity.

Planta Med 2019 Apr 1. Epub 2019 Apr 1.

Dipartimento di Farmacia, Università di Napoli Federico II, Napoli, Italy.

A general protocol for the selective mono-methylation of resorcinyl phytocannabinoids was developed. The availability of semisynthetic monomethyl analogues of cannabigerol, cannabidiol, and cannabidivarin (1A: -3A: , respectively) made it possible to quantify these minor phytocannabinoids in about 40 different chemotypes of fiber hemp. No chemotype significantly accumulated mono--methyl cannabidiol (2B: ) or its lower homologue (3B: ), while at least three chemotypes containing consistent amounts (≥ 400 mg/kg) of -methylcannabigerol (1B: ) were identified. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0883-5383
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http://dx.doi.org/10.1055/a-0883-5383DOI Listing
April 2019
6 Reads

Current Methods for the Discovery of New Active Ingredients from Natural Products for Cosmeceutical Applications.

Planta Med 2019 Mar 29. Epub 2019 Mar 29.

Tecnologico de Monterrey, Escuela de Ingeniería y Ciencias, Monterrey, N. L., México.

Cosmeceuticals are designed to serve a dual purpose: to provide desired esthetical effects and to treat dermatological conditions. Natural products derived from plants and marine organisms are a novel source of potential cosmeceutical active ingredients for incorporation into new formulations due to consumer demands. Contrary to common perceptions, most regulatory agencies do not view cosmeceuticals as being a separate category from cosmetics; thus, these products are not regulated accordingly, thereby forcing the consumer to rely on the self-regulatory policies of the cosmetics industry. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0857-6633
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http://dx.doi.org/10.1055/a-0857-6633DOI Listing
March 2019
1 Read
2.152 Impact Factor

Wound Healing Potential of the Standardized Extract of Boswellia serrata on Experimental Diabetic Foot Ulcer via Inhibition of Inflammatory, Angiogenetic and Apoptotic Markers.

Planta Med 2019 Mar 25. Epub 2019 Mar 25.

Department of Internal Medicine, Sichuan Provincial Orthopedic Hospital, Chengdu, P. R. China.

The aim of the present study was to evaluate the wound healing potential and possible mechanism of action of the standardized extract of against the experimental model of diabetic foot ulcer. -Boswellic acid was isolated from the standardized extract of and characterized (HPLC, H-NMR, C-NMR, ESI-MS). Diabetes was induced in Sprague-Dawley rats by streptozotocin (55 mg/kg, i. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0881-3000
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http://dx.doi.org/10.1055/a-0881-3000DOI Listing
March 2019
6 Reads

Antiplasmodial Lycorane Alkaloid Principles of the Plant Family Amaryllidaceae.

Planta Med 2019 Mar 25. Epub 2019 Mar 25.

Research Centre for Plant Growth and Development, University of KwaZulu-Natal Pietermaritzburg, Scottsville, South Africa.

The spread of malaria is thought to have followed human expansion out of Africa some 60 - 80 thousand years ago. With its prevalence in pantropical countries of the world and epicenter localized in Africa, malaria is now considered an unnecessary burden to overworked and under-resourced healthcare structures. Plants have long afforded a fertile hunting ground for the search and identification of structurally diverse antimalarial agents, such as quinine and artemisinin. Read More

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http://dx.doi.org/10.1055/a-0880-5414DOI Listing
March 2019
1 Read

Development and Validation of a UHPLC-DAD Method for the Quantitative Analysis of Major Dihydrochalcone Glucosides from Thonningia sanguinea VAHL.

Planta Med 2019 Mar 22. Epub 2019 Mar 22.

Institute of Pharmacy/Pharmacognosy, Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innsbruck, Austria.

is a plant widely used in traditional African medicine against a variety of diseases. The obligate parasite is growing throughout tropical African forests and utilizes a large variety of hosts. Dihydrochalcone glucoside derivatives isolated from the subaerial parts of this plant were identified as potential antidiabetic lead compounds. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0877-7255
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http://dx.doi.org/10.1055/a-0877-7255DOI Listing
March 2019
5 Reads

The Nonvolatile and Volatile Metabolites of Prangos ferulacea and Their Biological Properties.

Planta Med 2019 Mar 20. Epub 2019 Mar 20.

School of Pharmacy, University of Camerino, Camerino, Italy.

(L.) Lindl. (Fam. Read More

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http://dx.doi.org/10.1055/a-0873-8622DOI Listing
March 2019
2 Reads

Plant Allergen-Induced Contact Dermatitis.

Planta Med 2019 Mar 15. Epub 2019 Mar 15.

Allergy Research Group, Department of Dermatology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.

Although manifold beneficial effects of plant compounds for the treatment of skin disorders are known, cutaneous exposure to plants can also result in various types of incompatibility reactions such as contact dermatitis. In this mini-review, we briefly describe the different clinical forms of contact dermatitis (photoinduced, irritative, and allergic form) and highlight recent publications in the field of contact dermatitis. Major topics are recent recommendations regarding testing for plant contact dermatitis, advances in understanding the immunological mechanisms of plant contact dermatitis, and case reports for plant contact dermatitis. Read More

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http://dx.doi.org/10.1055/a-0873-1494DOI Listing
March 2019
4 Reads

The Wound Healing Properties of Betulin from Birch Bark from Bench to Bedside.

Authors:
Armin Scheffler

Planta Med 2019 Mar 11. Epub 2019 Mar 11.

Niefern-Öschelbronn, Germany.

With central European approval in January 2016 for a betulin-oleogel (Episalvan), used to accelerate wound closure in partial thickness wounds, the herbal active ingredient triterpene dry extract (betulin), from birch bark, was introduced into therapy for the first time. Clinical evidence of accelerated wound healing was provided in a new study design by means of intraindividual comparison of split-thickness skin graft donor wounds and burn wounds. Clinical results of a phase II study evidencing accelerated wound healing in the rare disease epidermolysis bullosa are also available, and a pivotal multi-centre phase III study is currently being conducted. Read More

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http://dx.doi.org/10.1055/a-0850-0224DOI Listing
March 2019
2 Reads

Magnesium Lithospermate B Derived from Salvia miltiorrhiza Ameliorates Right Ventricle Remodeling in Pulmonary Hypertensive Rats via Inhibition of NOX/VPO1 Pathway.

Planta Med 2019 Mar 1. Epub 2019 Mar 1.

Department of Pharmacology, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China.

Right ventricle (RV) remodeling is a major pathological feature in pulmonary arterial hypertension (PAH). Magnesium lithospermate B (MLB) is a compound isolated from the roots of and it possesses multiple pharmacological activities such as anti-inflammation and antioxidation. This study aims to investigate whether MLB is able to prevent RV remodeling in PAH and the underlying mechanisms. Read More

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http://dx.doi.org/10.1055/a-0863-4741DOI Listing

Editorial.

Planta Med 2019 Mar 26;85(4):273. Epub 2019 Feb 26.

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http://dx.doi.org/10.1055/a-0832-5297DOI Listing

Neuroprotective Effects of Dammarane-Type Saponins from Panax notoginseng on Glutamate-Induced Cell Damage in PC12 Cells.

Planta Med 2019 Feb 21. Epub 2019 Feb 21.

State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, People's Republic of China.

Dammarane-type saponins, the main active ingredients of , have substantial neuroprotective effects in different animal models of neurodegenerative diseases. However, because these compounds have different structures, the level of protection provided by individual compounds varies, and highly active compounds can be selected based on structure-activity relationships. Glutamate is a major excitatory neurotransmitter that plays an important role in synaptic response development. Read More

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http://dx.doi.org/10.1055/a-0853-7754DOI Listing
February 2019
2 Reads

Cytotoxic Alkaloids from Leaves of Pilea aff. martinii.

Planta Med 2019 Apr 21;85(6):496-502. Epub 2019 Feb 21.

Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry of the Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam.

Two new phenanthroquinolizidine alkaloids (1: and 2: ) and a new piperidine derivative (3: ) were isolated from the leaves of aff. together with 3 known alkaloids: julandine (4: ), cryptopleurine (5: ), and 1,3,6,6-tetramethyl-5,6,7,8-tetrahydro-isoquinolin-8-one (6: ). Their structures were determined by spectral data analyses including mass spectrometry and 2-dimensional nuclear magnetic resonance data. Read More

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http://dx.doi.org/10.1055/a-0826-0483DOI Listing
April 2019
2 Reads

Erratum: Brazilian Plants: An Unexplored Source of Endophytes as Producers of Active Metabolites.

Planta Med 2019 Feb 21. Epub 2019 Feb 21.

Federal University of Paraná, Department of Genetics, Curitiba, Brazil.

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http://dx.doi.org/10.1055/a-0861-1595DOI Listing
February 2019
2 Reads

New Benzaldehyde and Benzopyran Compounds from the Endophytic Fungus Paraphaeosphaeria sp. F03 and Their Antimicrobial and Cytotoxic Activities.

Planta Med 2019 Feb 19. Epub 2019 Feb 19.

Institute of Chemistry, São Paulo State University (Unesp), Araraquara, SP, Brazil.

Three new benzaldehyde derivatives, sporulosaldeins A - C (1: -3: ), and 3 new benzopyran derivatives, sporulosaldeins D - F (4: -6: ), were discovered from an endophytic fungus, sp. F03, which was isolated from leaves. Compounds 1: -6: were elucidated by 1- and 2-dimensional nuclear magnetic resonance experiments and high-resolution mass spectrometry analysis. Read More

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http://dx.doi.org/10.1055/a-0853-7793DOI Listing
February 2019
1 Read

Four New Cytotoxic Arborinane-Type Triterpenes from the Endolichenic Fungus Myrothecium inundatum.

Planta Med 2019 Feb 19. Epub 2019 Feb 19.

State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Chaoyang District, Beijing, China.

Two new arborinane-type triterpenes, myrotheols A (1: ) and B (2: ), two new arborinane-type glycosides, myrothesides C (3: ) and D (4: ), together with four known diterpenes (5:  - 8: ) were isolated from the ethyl acetate extract of the endolichenic fungus . The structures of new compounds 1:  - 4: were elucidated by NMR and MS analyses. The absolute configuration of 1: was assigned by a single-crystal X-ray diffraction experiment. Read More

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http://dx.doi.org/10.1055/a-0855-4051DOI Listing
February 2019
3 Reads

Pharmacokinetics and Tissue Distribution of Aegeline after Oral Administration in Mice.

Planta Med 2019 Apr 12;85(6):491-495. Epub 2019 Feb 12.

National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS, USA.

Aegeline is claimed to be a biologically active constituent of . Preclinical studies have reported possible therapeutic potential for aegeline against obesity and diabetes. In recent years, aegeline has been added to several weight loss products. Read More

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http://dx.doi.org/10.1055/a-0851-6879DOI Listing
April 2019
8 Reads

Brazilian Plants: An Unexplored Source of Endophytes as Producers of Active Metabolites.

Planta Med 2019 Feb 11. Epub 2019 Feb 11.

Federal University of Paraná, Department of Genetics, Curitiba, Brazil.

Brazil has an extraordinary biodiversity, and for many years, has been classified as the first of 17 countries with a mega diversity, with 22% of the total plants in the world (more than 55 000 species). Considering that some endophytes are host-specific, the incomparable plant diversity found in Brazil encompasses an immeasurable variety of habitats and may represent a repository of unexplored species. As a result of the endophyte-host interaction, plant-associated microorganisms have an enormous biosynthetic potential to produce compounds with novelties in structure and bioactivity. Read More

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http://dx.doi.org/10.1055/a-0847-1532DOI Listing
February 2019
2 Reads

Metabolism of Scoparone in Experimental Animals and Humans.

Planta Med 2019 Apr 8;85(6):453-464. Epub 2019 Feb 8.

School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.

Scoparone, a major constituent of the Chinese herbal medicine Yin Chen Hao, expresses beneficial effects in experimental models of various diseases. The intrinsic doses and effects of scoparone are dependent on its metabolism, both in humans and animals. We evaluated in detail the metabolism of scoparone in human, mouse, rat, pig, dog, and rabbit liver microsomes and in humans . Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0835-2301
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http://dx.doi.org/10.1055/a-0835-2301DOI Listing
April 2019
9 Reads

Icariin Attenuates High Glucose-Induced Apoptosis, Oxidative Stress, and Inflammation in Human Umbilical Venous Endothelial Cells.

Planta Med 2019 Apr 31;85(6):473-482. Epub 2019 Jan 31.

Department of Pathology & Pathophysiology, Wuhan University School of Basic Medical Sciences, Wuhan, China.

Endothelial dysfunction is closely associated with diabetic complications. Icariin, a flavonoid glycoside isolated from the plant species, exhibits antidiabetic properties. However, its impact on endothelial function remains poorly understood, particularly under hyperglycemia. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0837-0975
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http://dx.doi.org/10.1055/a-0837-0975DOI Listing
April 2019
19 Reads

Safety and Pharmacokinetics of Standardized Extract of Centella asiatica (ECa 233) Capsules in Healthy Thai Volunteers: A Phase 1 Clinical Study.

Planta Med 2019 Apr 30;85(6):483-490. Epub 2019 Jan 30.

Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.

The aim of this study was to investigate the safety and pharmacokinetic profiles of a newly developed, standardized extract of (ECa 233) capsule in healthy Thai volunteers. This study was designed as an open-labeled, 2-sequence dosage, single- and repeated-dose study investigated under fasting conditions. Plasma concentrations of the parent compounds and their relative acid metabolites were measured and pharmacokinetic parameters were calculated using noncompartmental analysis. Read More

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http://dx.doi.org/10.1055/a-0835-6671DOI Listing
April 2019
7 Reads
2.152 Impact Factor

Induction of Secondary Metabolites from the Marine-Derived Fungus Aspergillus versicolor through Co-cultivation with Bacillus subtilis.

Planta Med 2019 Apr 30;85(6):503-512. Epub 2019 Jan 30.

Institut für Pharmazeutische Biologie und Biotechnologie, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany.

A new cyclic pentapeptide, cotteslosin C (1: ), a new aflaquinolone, 22-epi-aflaquinolone B (3: ), and two new anthraquinones (9: and 10: ), along with thirty known compounds (2, 4:  - 8, 11:  - 34: ) were isolated from a co-culture of the sponge-associated fungus with . The new metabolites were only detected in the co-culture extract, but not when the fungus was grown under axenic conditions. Furthermore, the co-culture extract exhibited an enhanced accumulation of the known constituents versicolorin B (14: ), averufin (16: ), and sterigmatocyctin (19: ) by factors of 1. Read More

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http://dx.doi.org/10.1055/a-0835-2332DOI Listing
April 2019
2 Reads
2.152 Impact Factor

α-Tetralonyl Glucosides from the Green Walnut Husks of Juglans mandshurica and Their Antiproliferative Effects.

Planta Med 2019 Mar 28;85(4):335-339. Epub 2019 Jan 28.

School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.

Two new -tetralonyl glucosides, (4)-4,5,8-trihydroxy--tetralone-5---D-glucopyranosyl(1 → 6)--D-glucopyranoside (1: ) and (4)-4,8-dihydroxy--tetralone-4---D-glucopyranosyl(1 → 6)--D-glucopyranoside (2: ), together with eight known compounds (3:  - 10: ) were isolated from the green walnut husks of . The structural characterization of all compounds was performed by spectroscopic analyses, including 1D and 2D NMR and HR-ESI-MS experiments. The isolated compounds were assayed for their cytotoxicity against two human cancer cell lines, A549 and HeLa. Read More

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http://dx.doi.org/10.1055/a-0832-2328DOI Listing
March 2019
1 Read

Anti-Inflammatory Effect of a Novel Topical Herbal Composition (VEL-091604) Consisting of Gentian Root, Licorice Root and Willow Bark Extract.

Planta Med 2019 Jan 28. Epub 2019 Jan 28.

Research Center skinitial, Department of Dermatology, Medical Center, University of Freiburg, Freiburg, Germany.

The anti-inflammatory properties of the topical herbal composition VEL-091604 with gentian root, licorice root, and willow bark extract were assessed in a randomized, prospective, placebo-controlled, double-blind ultraviolet (UV)-erythema test study with 42 healthy volunteers in comparison to 1% hydrocortisone acetate. The efficacy and tolerability of VEL-091604 cream 2 times daily over 2 wk was evaluated in an open-label, prospective proof of concept study in 10 subjects with atopic dermatitis using a lesional SCORAD severity score. In the UV-erythema test VEL-091604 cream significantly reduced inflammation compared to placebo and was as effective as 1% hydrocortisone acetate. Read More

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http://dx.doi.org/10.1055/a-0835-6806DOI Listing
January 2019
3 Reads

Effects of Sideritis scardica Extract on Glucose Tolerance, Triglyceride Levels and Markers of Oxidative Stress in Ovariectomized Rats.

Planta Med 2019 Apr 28;85(6):465-472. Epub 2019 Jan 28.

Institute of Biochemistry, School of Medicine, University of Belgrade, Belgrade, Serbia.

Menopause is characterized by deep metabolic disturbances, including decreased insulin sensitivity, adiposity, and changes in lipid profiles. Estrogen replacement therapy can partially reverse these changes, and while it is safe in most healthy postmenopausal women, there are still existing concerns regarding an increased risk for breast and endometrial cancer as well as a risk for cardiovascular and thromboembolic disease. Therefore, certain natural compounds with positive metabolic effects may be considered as a possible alternative or adjunctive treatment in patients not willing to take estrogens or patients with contraindications for estrogens. Read More

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http://dx.doi.org/10.1055/a-0835-6622DOI Listing
April 2019
4 Reads

Editorial.

Planta Med 2019 Jan 22;85(2):93. Epub 2019 Jan 22.

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http://dx.doi.org/10.1055/a-0819-4096DOI Listing
January 2019
4 Reads

Natural Product Triterpenoids and Their Semi-Synthetic Derivatives with Potential Anticancer Activity.

Planta Med 2019 Jan 18. Epub 2019 Jan 18.

Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio, United States.

Triterpenoids are distributed widely in higher plants and are of interest because of their structural diversity and broad range of bioactivities. In particular, there is a very large literature on the propensity of a variety of triterpenoids to act as potential anticancer agents. In the present review, the anticancer potential is summarized for naturally occurring triterpenoids and their semi-synthetic derivatives, including examples of lupane-, oleanane-, ursane-, and cucurbitane-type pentacyclic triterpenoids, along with dammarane-type tetracyclic triterpenes including ginsenosides and their sapogenins and dichapetalins, which have been characterized as antitumor leads from higher plants. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0832-2383
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http://dx.doi.org/10.1055/a-0832-2383DOI Listing
January 2019
13 Reads

Cytotoxic Prenylated Xanthones from the Leaves of Garcinia bracteata.

Planta Med 2019 Apr 16;85(6):444-452. Epub 2019 Jan 16.

School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.

Six new prenylated xanthones (1: -6: ) and seventeen known xanthones were isolated from extracts of leaves. Their structures were determined by extensive NMR and MS spectroscopic data analysis. The inhibitory activities of the isolates were assayed on HeLa, A549, PC-3, HT-29, and WPMY-1 cell lines. Read More

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http://dx.doi.org/10.1055/a-0828-9831DOI Listing
April 2019
20 Reads

Triterpenoids from Hibiscus sabdariffa L. with PPARδ/γ Dual Agonist Action: In Vivo, In Vitro and In Silico Studies.

Planta Med 2019 Mar 16;85(5):412-423. Epub 2019 Jan 16.

Laboratorio de Farmacología, Departamento de Ciencias de la Salud, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, Ciudad de México, México.

is a medicinal plant consumed as a diuretic and anti-obesity remedy. Several pharmacological studies have shown its beneficial effects in metabolism. Peroxisome proliferator-activated receptors and may play a role in the actions of These nuclear receptors regulate lipid and glucose metabolism and are therapeutic targets for type 2 diabetes. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0824-1316
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http://dx.doi.org/10.1055/a-0824-1316DOI Listing
March 2019
11 Reads
2.152 Impact Factor

Analysis of Terpenes in Cannabis sativa L. Using GC/MS: Method Development, Validation, and Application.

Planta Med 2019 Mar 15;85(5):431-438. Epub 2019 Jan 15.

National Center for Natural Products Research, University of Mississippi, University, MS, USA.

Terpenes are the major components of the essential oils present in various L. varieties. These compounds are responsible for the distinctive aromas and flavors. Read More

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http://dx.doi.org/10.1055/a-0828-8387DOI Listing
March 2019
30 Reads

Antiprotozoal Germacranolide Sesquiterpene Lactones from Tanacetum sonbolii.

Planta Med 2019 Mar 8;85(5):424-430. Epub 2019 Jan 8.

Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G. C., Evin, Tehran, Iran.

A phytochemical investigation of extracts from flowers and aerial parts of afforded 7 new germacranolide sesquiterpene lactones. The structures were established by a combination of 1- and 2-dimensional nuclear magnetic resonance spectroscopy, high-resolution mass spectrometry, and electronic circular dichroism. The antiprotozoal activity of the compounds against and cytotoxicity against rat myoblast (L6) cells were determined. Read More

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http://dx.doi.org/10.1055/a-0824-1294DOI Listing
March 2019
7 Reads

Catalpol Ameliorates Neointimal Hyperplasia in Diabetic Rats.

Planta Med 2019 Mar 4;85(5):406-411. Epub 2019 Jan 4.

Department of Emergency Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.

Catalpol, an iridoid glycoside, is an isolated natural product of , which has been reported to have antidiabetic properties. This study investigated the vascular protective effects of catalpol in hyperglycemic rats with balloon-injured carotid arteries. Balloon injury stress led to the upregulation of monocyte chemoattractant protein-1 expression in rats with streptozotocin-induced diabetes. Read More

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http://dx.doi.org/10.1055/a-0818-3689DOI Listing
March 2019
4 Reads

Inhibitory Effects of Pterocarpus santalinus Extract against IgE/Antigen-Sensitized Mast Cells and Atopic Dermatitis-Like Skin Lesions.

Planta Med 2019 Jan 4. Epub 2019 Jan 4.

Graduate School of Energy and Environment, Korea University, Seoul, South Korea.

has been traditionally used as a medicinal plant owing to its anti-inflammatory, anthelmintic, tonic, antihyperglycemic, and diaphoretic properties. We hypothesized that might have therapeutic potential in alleviating allergy and atopic dermatitis. Thus, we investigated the inhibitory effects of extract against allergic responses and 2,4-dinitrochlorobenzene-induced atopic dermatitis-like dorsal skin lesions using immunoglobulin E-sensitized rat basophilic leukemia-2H3 mast cells and NC/Nga mice. Read More

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http://dx.doi.org/10.1055/a-0824-1282DOI Listing
January 2019
9 Reads

Editorial.

Planta Med 2019 Jan 3;85(1). Epub 2019 Jan 3.

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http://dx.doi.org/10.1055/a-0774-4019DOI Listing
January 2019
4 Reads

Inhibitory Effect of Damulin B from Gynostemma pentaphyllum on Human Lung Cancer Cells.

Planta Med 2019 Mar 18;85(5):394-405. Epub 2018 Dec 18.

School of Pharmacy, Minzu University of China, Beijing, China.

Damulin B, a dammarane-type saponin from steamed , exhibits the strongest activity against human lung carcinoma A549 cells among the isolated active saponins. In this study, the structure-activity relationship of a series of saponin compounds was discussed. The inhibitory effect of damulin B on human lung cancer A549 and H1299 cells was investigated from apoptosis, cell cycle, and migration aspects. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0810-7738
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http://dx.doi.org/10.1055/a-0810-7738DOI Listing
March 2019
6 Reads

A Bufadienolide-Enriched Fraction of Bryophyllum pinnatum Inhibits Human Myometrial Contractility In Vitro.

Planta Med 2019 Mar 18;85(5):385-393. Epub 2018 Dec 18.

Department of Obstetrics, University Hospital Zurich, Zurich, Switzerland.

has been used since the 1970s to prevent premature labour, first in anthroposophic hospitals and, more recently, also in the main Swiss perinatal centres. However, it is not known which compounds in leaves contribute to the tocolytic effect. Here we studied the effects of a flavonoid-enriched fraction, the corresponding flavonoid aglycon mixture, a bufadienolide-enriched fraction, and leaf press juice on human myometrial contractility . Read More

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http://dx.doi.org/10.1055/a-0810-7704DOI Listing
March 2019
3 Reads

Pharmacokinetics of Prenylflavonoids following Oral Ingestion of Standardized Epimedium Extract in Humans.

Planta Med 2019 Mar 6;85(4):347-355. Epub 2018 Dec 6.

Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Leaves of the plant are traditionally consumed for bone health and other indications. The aim of this study was to establish the safety and pharmacokinetics of the metabolites of prenylflavonoids (icariin, icariside I, icariside II, icaritin, and desmethylicaritin) following single doses of a defined prenylflavonoid extract in humans. A single oral dose of 370, 740, or 1110 mg of a standardized prenylflavonoid extract was administered to 30 healthy male subjects in a randomized, placebo-controlled trial. Read More

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http://dx.doi.org/10.1055/a-0806-7673DOI Listing
March 2019
18 Reads
2.152 Impact Factor

Erratum: Piper nigrum Oil - Determination of Selected Terpenes for Quality Evaluation.

Planta Med 2019 Feb 3;85(3):e1. Epub 2018 Dec 3.

National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS, USA.

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http://dx.doi.org/10.1055/a-0808-3238DOI Listing
February 2019
6 Reads

The Petroleum Ether Extract from Hypericum perforatum Root Cultures Exhibits Potent Antiproliferative Activity in Human Keratinocytes and Fibroblasts.

Planta Med 2018 Dec 4. Epub 2018 Dec 4.

Institut für Pharmazeutische Technologie, Technische Universität Braunschweig, Germany.

The hyperforin content of herb was repeatedly reported to be responsible for a multitude of pharmacological activities. Our recent report about the hyperforin accumulation in root cultures of provides an alternative perspective to achieve constant product quality and to serve the rapidly growing market. In this study, the antiproliferative effect of a petroleum ether extract from the root cultures was investigated. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0806-7735
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http://dx.doi.org/10.1055/a-0806-7735DOI Listing
December 2018
17 Reads

From the Outgoing Editor in Chief.

Planta Med 2018 Dec 28;84(18):1317. Epub 2018 Nov 28.

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0766-8081
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http://dx.doi.org/10.1055/a-0766-8081DOI Listing
December 2018
4 Reads

A Review of Plants Used in South African Traditional Medicine for the Management and Treatment of Hypertension.

Planta Med 2019 Mar 26;85(4):312-334. Epub 2018 Nov 26.

Phytomedicine and phytopharmacology Research Group, Department of Plant Sciences, University of the Free State, QwaQwa Campus, South Africa.

South Africa contains 9% of the world's higher plants, and despite its rich biodiversity, it has one of the highest prevalence of hypertension in Africa. This review provides information on medicinal plants embraced in South Africa for hypertension management, with the aim of reporting pharmacological information on the indigenous use of these plants as antihypertensives. This review not only focuses on the activity of antihypertensive medicinal plants but also reports some of its phytochemical constituents and other ethnopharmacological and therapeutic properties. Read More

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http://dx.doi.org/10.1055/a-0801-8771DOI Listing
March 2019
2 Reads

Baicalin Induces Apoptotic Death of Human Chondrosarcoma Cells through Mitochondrial Dysfunction and Downregulation of the PI3K/Akt/mTOR Pathway.

Planta Med 2019 Mar 23;85(5):360-369. Epub 2018 Nov 23.

Department of Spine Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

The aim of the present study was to investigate the cytotoxic and antitumour effects of baicalin in human chondrosarcoma both and . We examined the effects of baicalin on the growth and apoptosis of human chondrosarcoma cells. Baicalin inhibited the growth of SW1353 and CH2879 cells in a dose- and time-dependent manner, but did not inhibit the growth of normal chondrocytes. Read More

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http://dx.doi.org/10.1055/a-0791-1049DOI Listing
March 2019
13 Reads

Anti-inflammatory and Quinone Reductase-Inducing Compounds from Beilschmiedia mannii.

Planta Med 2019 Mar 22;85(5):379-384. Epub 2018 Nov 22.

School of pharmaceutical sciences, University of Geneva, University of Lausanne, Geneva, Switzerland.

Previous studies on the therapeutic potential of plant species found in the diet of chimpanzees living in Taï National Park have shown that they could be potential candidates for the search of new molecules useful for humans. Based on the screening of some of these plants, the fruits of , whose dichloromethane extract showed cancer chemopreventive properties, were selected. Bioactivity-guided fractionation of the extract resulted in the isolation and identification of two -pyrones, including desmethoxydihydromethysticin (1: ), found in a natural source for the first time, and a new congener, beilschmiediapyrone (2: ), as well as five known alkamides (3:  - 7: ). Read More

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http://dx.doi.org/10.1055/a-0798-3155DOI Listing
March 2019
19 Reads
2.152 Impact Factor

Cucurbitacin B Induces Hypermethylation of Oncogenes in Breast Cancer Cells.

Planta Med 2019 Mar 21;85(5):370-378. Epub 2018 Nov 21.

Department of Clinical Microscopy, Faculty of Medical Technology, Mahidol University, Nakhon Pathom, Thailand.

Breast cancer is a complex disease driven by multiple factors including both genetic and epigenetic alterations. Recent studies revealed that abnormal gene expression induced by epigenetic changes including aberrant promoter methylation plays a critical role in human breast carcinogenesis. Cucurbitacin B has antiproliferative activity against various human breast cancer cells, but the molecular mechanism is not completely understood. Read More

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http://dx.doi.org/10.1055/a-0791-1591DOI Listing
March 2019
8 Reads

Anti-Inflammatory Activity of Lobaric Acid via Suppressing NF-κB/MAPK Pathways or NLRP3 Inflammasome Activation.

Planta Med 2019 Mar 16;85(4):302-311. Epub 2018 Nov 16.

School of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea.

Lobaric acid (LA) is a constituent of the lichen . LA has multiple biological activities, including antibacterial and antioxidant ones. The purpose of this study was to investigate the effect of LA and its mechanism on lipopolysaccharide (LPS)-induced inflammatory responses in macrophages. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0777-2420
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http://dx.doi.org/10.1055/a-0777-2420DOI Listing
March 2019
10 Reads

Comparative Pharmacokinetics of Mitragynine after Oral Administration of Mitragyna speciosa (Kratom) Leaf Extracts in Rats.

Planta Med 2019 Mar 16;85(4):340-346. Epub 2018 Nov 16.

Department of BioMolecular Sciences, School of Pharmacy, The University of Mississippi, University, MS, USA.

Kratom () has been examined for its opioid activity, especially for the treatment of opioid withdrawal and pain. Mitragynine, the most abundant alkaloid in kratom, is thought to be the major psychoactive alkaloid. An HPLC method was developed for the quantification of mitragynine in kratom leaf extracts. Read More

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http://dx.doi.org/10.1055/a-0770-3683DOI Listing
March 2019
3 Reads