70 results match your criteria Plant Poisoning Herbs

Systematic investigation on the distribution of four hidden toxic Aconitum alkaloids in commonly used Aconitum herbs and their acute toxicity.

J Pharm Biomed Anal 2022 Jan 16;208:114471. Epub 2021 Nov 16.

Faculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macao 999078, PR China; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, Macau University of Science and Technology, Macao 999078, PR China. Electronic address:

Yunaconitine (YAC), crassicauline A (CCA), 8-deacetylyunaconitine (DYA), and 8-deacetylcrassicauline A (DCA), as hidden toxic Aconitum alkaloids, are detected in some products of processed Aconitum carmichaelii lateral root and poisoning cases. The distribution and toxicity of these four components in Aconitum herbs should be further systematically studied for medication safety. This study developed a new UHPLC-QQQ-MS/MS method to determine ten Aconitum alkaloids, including aconitine, mesaconitine, hypaconitine, benzoylaconine, benzoylmesaconine, benzoylhypaconine, YAC, CCA, DYA, and DCA, for Aconitum herbs simultaneously. Read More

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January 2022

[Aconitine poisoning due to confusion of aconite leaves with lovage].

Anaesthesist 2021 08 12;70(8):633-638. Epub 2021 Jul 12.

Zentrum für Kinder- und Jugendmedizin, Vergiftungs-Informations-Zentrale, Universitätsklinikum Freiburg, Breisacher Straße 86b, 79110, Freiburg, Deutschland.

Due to a mix-up an older couple (69 years and 71 years) ate a meal with herbs from their garden that contained leaves of monkshood (Aconitum napellus). The monkshood plants grew close to the herbs in their garden. Both patients developed the typical symptoms of aconitine poisoning with paresthesia, hypotension and bradycardia. Read More

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Health Hazard Assessment Due to Slimming Medicinal Plant Intake.

Biol Trace Elem Res 2022 Mar 22;200(3):1442-1454. Epub 2021 May 22.

GEBABS - Group of Spectroscopy and Bioinformatics Applied Biodiversity and Health, Federal University of Mato Grosso do Sul, Campo Grande, 79070-900, Brazil.

According to the World Health Organization (WHO), about 80% of people rely on medicinal plants for their primary health needs. Traditional medicine's principal benefits are their vast population knowledge, low severe adverse effects rate, low cost, and the lack of a medical prescription to use them. While obesity has become a global health issue, an increase in finding cheap and fast ways to lose weight escalates medicinal herbs' use for this purpose, both in dietary supplements or in teas. Read More

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Toxicity of herbal medications suggested as treatment for COVID-19: A narrative review.

J Am Coll Emerg Physicians Open 2021 Apr 31;2(2):e12411. Epub 2021 Mar 31.

Department of Emergency Medicine Newark Beth Israel Medical Center Newark New Jersey USA.

Objectives: In the absence of a definitive cure, herbal medications are gaining increasing popularity in the general public for treatment of coronavirus disease 2019 (COVID-19). Although many herbal preparations are safe and can be used without complication, serious toxicities do occur. This article focuses on the major characteristics and toxicities of herbal preparations that have been proposed as treatments for COVID-19. Read More

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[Status of content analysis of pyrrolizidine alkaloids in food and herbs].

Zhongguo Zhong Yao Za Zhi 2020 Nov;45(22):5421-5428

Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100193, China.

Pyrrolizidine alkaloids(PAs) are a group of naturally occurring alkaloids with a pyrrolizidine skeleton which can be found in about 3% of the world's flowering plants. It is notorious that PAs are cause the hepatoxic and genotoxic-carcinogenic effects by taking PA-containing herbs, food and dietary supplements. In order to control the poisoning caused by PAs, European Medicines Agency has set a limit of intake of PAs from herbal medicinal products at 0. Read More

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November 2020

[A poisonous spring smoothie with wild herbs: accidental intoxication with foxglove (Digitalis purpurea)].

Ned Tijdschr Geneeskd 2020 11 12;164. Epub 2020 Nov 12.

St. Antonius ziekenhuis, afd. Klinische Farmacie,Nieuwegein.

Background: At a time when self-sufficiency and health are becoming increasingly important in society, the chances of intoxications with wild plants are increasing. Foxglove contains poisonous cardiac glycosides such as digoxin, digitoxin and gitoxin. The levels vary greatly and depend on the season and the location of the plants. Read More

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November 2020

Tu-San-Qi (Gynura japonica): the culprit behind pyrrolizidine alkaloid-induced liver injury in China.

Acta Pharmacol Sin 2021 Aug 5;42(8):1212-1222. Epub 2020 Nov 5.

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.

Herbs and dietary supplement-induced liver injury (HILI) is the leading cause of drug-induced liver injury in China. Among different hepatotoxic herbs, the pyrrolizidine alkaloid (PA)-producing herb Gynura japonica contributes significantly to HILI by inducing hepatic sinusoidal obstruction syndrome (HSOS), a liver disorder characterized by hepatomegaly, hyperbilirubinemia, and ascites. In China, G. Read More

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Authentication, phytochemical characterization and anti-bacterial activity of twoArtemisiaspecies.

Food Chem 2020 Dec 4;333:127458. Epub 2020 Jul 4.

Agricultural Biotechnology Research Center, Academia Sinica, Taipei, Taiwan; Molecular and Biological Agricultural Sciences Program, Taiwan International Graduate Program, National Chung Hsing University and Academia Sinica, Taipei, Taiwan; Graduate Institute of Biotechnology, National Chung Hsing University, Taichung, Taiwan; Graduate Program of Marine Biotechnology, National Taiwan Ocean University and Academia Sinica, Keelung, Taiwan; Department of Institute of Biotechnology, National Taiwan University, Taipei, Taiwan; Institute of Pharmacology, National Yang-Ming University, Taipei, Taiwan; Biotechnology Center, National Chung Hsing University, Taichung, Taiwan; Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan. Electronic address:

Artemisia species are aromatic herbs used as food and/or ethnomedicine worldwide; however, the use of these plants is often impeded by misidentification. Here, molecular and chemotaxonomic approaches were combined to assist in the morphology-based authentication of Artemisia species, and Artemisia indica and Artemisia argyi were identified. The plant extracts and compounds obtained from these species, 1,8-cineole, carveol, α-elemene, α-farnesene, methyl linolenate, diisooctyl phthalate inhibited the growth of food-borne harmful bacteria. Read More

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December 2020

Biofilm Eradication Activity of Herb and Spice Extracts Alone and in Combination Against Oral and Food-Borne Pathogenic Bacteria.

Curr Microbiol 2020 Sep 11;77(9):2486-2495. Epub 2020 May 11.

Fukuoka Industrial Technology Center, Chikushino, Japan.

The purpose of this study was to select herbs and spices with potent biofilm eradication activities. Further, the combined effects of herb and spice extracts against pathogenic biofilms were evaluated. The biofilm eradication activities of ethanol extracts of 104 herbs and spices were measured by combining a colorimetric microbial viability assay with a biofilm formation technique. Read More

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September 2020

Toxicity of Herbs, Vitamins, and Supplements.

Adv Chronic Kidney Dis 2020 01;27(1):67-71

Department of Medicine/Division of Nephrology, Mount Sinai Beth Israel/Icahn School of Medicine, New York, NY. Electronic address:

In the United States, the Food and Drug Administration regulates the efficacy and safety of pharmaceutical drugs. This government agency was formed in direct response to a mass poisoning and more than 100 deaths from kidney failure due to a medicinal toxic alcohol exposure. In contrast, the Food and Drug Administration also regulates the use of vitamins, minerals, herbs, or botanicals as dietary supplements, banning specific medical claims but requiring no documentation of efficacy. Read More

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January 2020

[Research advancement in mechanisms of processing and compatibility for detoxication of Aconitums].

Zhongguo Zhong Yao Za Zhi 2019 Sep;44(17):3695-3704

State Key Laboratory Breeding Base of Dao-di Herbs,National Resource Center for Chinese Materia Medica,China Academy of Chinese Medical Sciences Beijing 100700,China.

Aconitums,represented by Aconite Radix,Aconiti Lateralis Radix Praeparata and Aconiti Kusnezoffh Folium,is a kind of traditional Chinese medicine with a long medicinal history in China. They possess the significant toxicity and therapeutic effects simultaneously. Their potent effects of rescuing from dying,curing rheumatism,anti-inflammation,and analgesia make Aconitums highly regarded by physicians and pharmacists of various dynasties. Read More

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September 2019

A fatal case of self-poisoning through the ingestion of oleander leaves.

J Forensic Leg Med 2019 Jul 22;65:133-136. Epub 2019 May 22.

Forensic Medicine Unit, Section of Public Health and Human Sciences, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Piazzale Spedali Civili, 1, 25123, Brescia, Italy. Electronic address:

Background: Benefits and even dangers of plants are known since time began. The ancients used plants and herbs because of their effects on the human body. Poisoning is a logical consequence of their use: history is full of episodes of plants and herbs poisoning, whether intentional or accidental. Read More

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The potential modulatory role of herbal additives against Cd toxicity in human, animal, and poultry: a review.

Environ Sci Pollut Res Int 2019 Feb 5;26(5):4588-4604. Epub 2019 Jan 5.

Department of Poultry, Faculty of Agriculture, Zagazig University, Zagazig, 44511, Egypt.

Cadmium (Cd) is a heavy and toxic metal and easily absorbed by animals and plants; subsequently, it is an environmental risk factor with several toxic effects in humans and animals. The main pathway of human or animal exposure to Cd is through its ingestion by water or food and by particles or fume inhalation during industrial processes. With continuous exposure to small levels of cadmium, it is being deposited in different tissues day after day, causing toxic effects on the liver, kidney, and testes. Read More

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February 2019

Accumulation of heavy metals from soil in medicinal plants.

Arh Hig Rada Toksikol 2017 Sep;68(3):236-244


Medicinal plants accumulate heavy metals from contaminated soil, and their consumption can cause poisoning. Our objective was to determine the levels of Pb, Cd, Zn, Cu, Fe, and Mn in four medicinal plant species (Achillea millefolium, Hypericum perforatum, Plantago lanceolata, and Urtica dioica) and their native soil, all sampled at a former smelter. The highest soil Cd, Pb, and Zn levels surpassed the maximum allowed limit 75-fold, 48-fold, and 14-fold, respectively. Read More

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September 2017

Yellow Oleander Seed, or "Codo de Fraile" (Thevetia spp.): A Review of Its Potential Toxicity as a Purported Weight-Loss Supplement.

J Diet Suppl 2018 May 28;15(3):352-364. Epub 2017 Sep 28.

a School of Pharmacy , University of Texas at El Paso , El Paso , TX , USA.

The Dietary Supplements and Health Education Act (DSHEA), passed by the United States Congress in October of 1994, defines herbal products as nutritional supplements, not medications. This opened the market for diverse products made from plants, including teas, extracts, essential oils, and syrups. Mexico and the United States share an extensive border, where diverse herbal products are available to the public without a medical prescription. Read More

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Worldwide Occurrence and Investigations of Contamination of Herbal Medicines by Tropane Alkaloids.

Thomas Y K Chan

Toxins (Basel) 2017 09 15;9(9). Epub 2017 Sep 15.

Division of Clinical Pharmacology and Drug and Poisons Information Bureau, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China.

Tropane alkaloids occur mainly in plants. In the present review, the main objective is to describe the worldwide occurrence and investigations of anticholinergic poisoning due to the contamination of herbal teas and herbs by tropane alkaloids. Tropane alkaloid poisoning can occur after consumption of any medicinal plant if plants or plant parts are present as contaminants. Read More

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September 2017

Toxic pyrrolizidine alkaloids provide a warning sign to overuse of the ethnomedicine Arnebia benthamii.

J Ethnopharmacol 2018 Jan 12;210:88-94. Epub 2017 Aug 12.

College of Life Science, Beijing Normal University, Beijing 100875, China.

Ethnopharmacological Relevance: From early times man has used medicinal plants for the treatment of various ailments and basic health care needs. The use of herbal medicines has increased day by day and with this, so do reports of adverse events, poisoning, and suspected toxicity. Similarly, the indigenous communities of Neelum Valley in Azad Kashmir commonly use Arnebia benthamii (Wall. Read More

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January 2018

Protective effect of Dracontium dubium against Bothrops asper venom.

Biomed Pharmacother 2017 May 11;89:1105-1114. Epub 2017 Mar 11.

Biological Evaluation of Promising Substances Group, Faculty of Pharmaceutical Sciences, University of Cartagena, Cartagena, 130015, Colombia. Electronic address:

In Colombia, Bothrops asper is responsible for 70-90% of ophidians accidents reported annually. Envenoming occurs mainly in rural areas where both antivenom and health centers are scarce. Thus, patients are frequently treated by local healers that employ medicinal herbs; including several species belonging to Dracontium genus. Read More

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Ameliorative effect of two Ayurvedic herbs on experimentally induced arsenic toxicity in calves.

J Ethnopharmacol 2017 Feb 3;197:266-273. Epub 2016 Aug 3.

Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary and Animal Sciences, West Bengal University of Animal and Fishery Sciences, Kolkata, India.

Ethnopharmacological Relevance: Chronic arsenic poisoning due to contaminated subsoil water is a threat to society in West Bengal, India and in Bangladesh. The human being may also be affected by the exposed cattle from the affected area by consuming milk, egg, meat and others. In Ayurveda, several herbs like Haridra (turmeric), Shunthi (dried ginger root) and others are used for the management of arsenic poisoning. Read More

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February 2017

Poisoning by Herbs and Plants: Rapid Toxidromic Classification and Diagnosis.

James H Diaz

Wilderness Environ Med 2016 Mar;27(1):136-52

Department of Environmental and Occupational Health Sciences, School of Public Health; Department of Anesthesiology/Critical Care, School of Medicine, Louisiana State University Health Sciences Center (LSUHSC) in New Orleans, New Orleans, LA. Electronic address:

The American Association of Poison Control Centers has continued to report approximately 50,000 telephone calls or 8% of incoming calls annually related to plant exposures, mostly in children. Although the frequency of plant ingestions in children is related to the presence of popular species in households, adolescents may experiment with hallucinogenic plants; and trekkers and foragers may misidentify poisonous plants as edible. Since plant exposures have continued at a constant rate, the objectives of this review were (1) to review the epidemiology of plant poisonings; and (2) to propose a rapid toxidromic classification system for highly toxic plant ingestions for field use by first responders in comparison to current classification systems. Read More

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Aconitum Alkaloid Poisoning Because of Contamination of Herbs by Aconite Roots.

Thomas Y K Chan

Phytother Res 2016 Jan 19;30(1):3-8. Epub 2015 Oct 19.

Division of Clinical Pharmacology and Drug and Poisons Information Bureau, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China.

Aconitum alkaloid poisoning can occur after drinking decoction and soup made from non-toxic herbs contaminated by aconite roots. In the present review, the main objective is to describe the clinical features, investigations and possible sources of contamination. A combination of neurological, gastrointestinal and cardiovascular signs and symptoms was seen. Read More

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January 2016

[The Indigenization of Licorice and Its Meaning During the Early Days of the Joseon Dynasty].

Kyung-Lock Lee

Uisahak 2015 Aug;24(2):423-55

Handok Museum of Medicine and Pharmacy, Eumseong-gun, Chungcheongbuk-do, KOREA.

This article explores the indigenization of licorice(Glycyrrhiza uralensis Fisch.) which was the most important medicine of the Oriental Medicine. There are a lot of records on licorice even before the Joseon Dynasty. Read More

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Incidence and Causes of Aconitum Alkaloid Poisoning in Hong Kong from 1989 to 2010.

Thomas Y K Chan

Phytother Res 2015 Aug 14;29(8):1107-11. Epub 2015 May 14.

Division of Clinical Pharmacology and Drug and Poisons Information Bureau, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China.

Aconite roots contain Aconitum alkaloids, which are highly toxic cardiotoxins and neurotoxins. In this review, the main objective was to determine the incidence and causes of Aconitum alkaloid poisoning in Hong Kong between 1989 and 2010, based on six published reports from the territory-wide poison control units. In the New Territories East of Hong Kong, the incidence of aconite poisoning showed a sudden and sustained decrease from 0. Read More

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Persistent metabolic acidosis and severe diarrhoea due to Artemisia absinthium poisoning.

J Pak Med Assoc 2014 Sep;64(9):1081-3

Herbs have long been used in the treatment of various disorders in traditional medicine since ancient age. Artemisia absinthium, one of these herbs, has traditionally been used in different societies for antibiotic, antiparasitic, antifungal and antipyretic purposes. Here, we report a poisoning case of a 10-month-old male infant progressing with severe diarrhoea and persistent metabolic acidosis after ingesting home-prepared Artemisia absinthium extract which was given for the treatment of common cold. Read More

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September 2014

A review on phytochemistry, pharmacology and toxicology studies of Aconitum.

J Pharm Pharmacol 2015 Jan 22;67(1):1-19. Epub 2014 Sep 22.

Tianjin State Key Laboratory of Modern Chinese Medicine, School of Traditional Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, China; Rwanda Standards Board, Kigali, Republic of Rwanda.

Objectives: A number of species belonging to herbal genus Aconitum are well-known and popular for their medicinal benefits in Indian, Vietnamese, Korean, Japanese, Tibetan and Chinese systems of medicine. It is a valuable drug as well as an unpredictable toxic material. It is therefore imperative to understand and control the toxic potential of herbs from this genus. Read More

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January 2015

Ozone and ozone injury on plants in and around Beijing, China.

Environ Pollut 2014 Aug;191:215-22

Institute of Hydrogeology and Environmental Geology, Chinese Academy of Geological Science, Shijiazhuang 050061, China.

Ozone (O3) levels were assessed for the first time with passive samplers at 10 sites in and around Beijing in summer 2012. Average O3 concentrations were higher at locations around Beijing than in the city center. Levels varied with site locations and ranged from 22. Read More

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Induction of Nrf2 and metallothionein as a common mechanism of hepatoprotective medicinal herbs.

Am J Chin Med 2014 ;42(1):207-21

Department of Pharmacology and Key Lab for Basic Pharmacology of Ministry of Education, Zunyi Medical College, Zunyi 563003, P. R. China.

Many Chinese medicines have the potential to be hepatoprotective and therefore can be used to treat acute and chronic liver diseases. The challenge is to identify the molecular target for their protective mechanism. This study investigated the induction of nuclear factor-erythroid 2(NF-E2)-related factor 2 (Nrf2) antioxidant genes and metallothionein as a common mechanism of hepatoprotective effects of Chinese medicines such as Piper puberulum. Read More

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September 2014

Total and inorganic arsenic in dietary supplements based on herbs, other botanicals and algae--a possible contributor to inorganic arsenic exposure.

Anal Bioanal Chem 2013 May 24;405(13):4429-35. Epub 2013 Feb 24.

National Food Institute, Division of Food Chemistry, Technical University of Denmark, Søborg, Denmark.

The content of total and inorganic arsenic was determined in 16 dietary supplements based on herbs, other botanicals and algae purchased on the Danish market. The dietary supplements originated from various regions, including Asia, Europe and USA. The contents of total and inorganic arsenic was determined by inductively coupled plasma mass spectrometry (ICP-MS) and anion exchange HPLC-ICP-MS, respectively, were in the range of 0. Read More

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Possible health impacts of naturally occurring uptake of aristolochic acids by maize and cucumber roots: links to the etiology of endemic (Balkan) nephropathy.

Environ Geochem Health 2013 Apr 1;35(2):215-26. Epub 2012 Aug 1.

Institute for Biomedical Research, Medical Faculty, University of Nis, Nis, Serbia.

Aristolochic acids (AAs) are nephrotoxic and carcinogenic derivatives found in several Aristolochia species. To date, the toxicity of AAs has been inferred only from the effects observed in patients suffering from a kidney disease called "aristolochic acid nephropathy" (AAN, formerly known as "Chinese herbs nephropathy"). More recently, the chronic poisoning with Aristolochia seeds has been considered to be the main cause of Balkan endemic nephropathy, another form of chronic renal failure resembling AAN. Read More

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The antioxidant effect of β-caryophyllene protects rat liver from carbon tetrachloride-induced fibrosis by inhibiting hepatic stellate cell activation.

Br J Nutr 2013 Feb 1;109(3):394-401. Epub 2012 May 1.

Instituto de Nutrición y Tecnología de los Alimentos, Centro de Investigación Biomédica, Armilla, Spain.

Plant-based whole foods provide thousands of bioactive metabolites to the human diet that reduce the risk of developing chronic diseases. β-Caryophyllene (CAR) is a common constituent of the essential oil of numerous plants, vegetables, fruits and medicinal herbs, and has been used as a flavouring agent since the 1930 s. Here, we report the antioxidant activity of CAR, its protective effect on liver fibrosis and its inhibitory capacity on hepatic stellate cell (HSC) activation. Read More

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February 2013