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    80 results match your criteria Plant Poisoning Hemlock

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    Intravenous Poison Hemlock Injection Resulting in Prolonged Respiratory Failure and Encephalopathy.
    J Med Toxicol 2017 Jun 6;13(2):180-182. Epub 2017 Feb 6.
    Department of Emergency Medicine, Wake Forest Baptist Medical Center, Meads Hall 1 Medical Center Blvd, Winston Salem, NC, 27103, USA.
    Background: Poison hemlock (Conium maculatum) is a common plant with a significant toxicity. Data on this toxicity is sparse as there have been few case reports and never a documented poisoning after intravenous injection.

    Objectives: We present a case of intravenous poison hemlock injection encountered in the emergency department. Read More

    Alkaloid-Containing Plants Poisonous to Cattle and Horses in Europe.
    Toxins (Basel) 2015 Dec 8;7(12):5301-7. Epub 2015 Dec 8.
    Department of Health, Animal Science and Food Safety (VESPA), Università degli Studi di Milano, Via Celoria 10, 20133 Milan, Italy.
    Alkaloids, nitrogen-containing secondary plant metabolites, are of major interest to veterinary toxicology because of their occurrence in plant species commonly involved in animal poisoning. Based on epidemiological data, the poisoning of cattle and horses by alkaloid-containing plants is a relatively common occurrence in Europe. Poisoning may occur when the plants contaminate hay or silage or when forage alternatives are unavailable. Read More

    Hemlock (Conium Maculatum) Poisoning In A Child.
    Turk J Emerg Med 2014 Mar 26;14(1):34-6. Epub 2016 Feb 26.
    Department of Pediatrics, Gaziantep Children Health and Diseases Hospital, Gaziantep.
    Poison hemlock (Conium maculatum) is a plant that is poisonous for humans and animals. Accidental ingestion of the plant may result in central nervous system depression, respiratory failure, acute rhabdomyolysis, acute renal failure and even death. The main treatment of hemlock poisoning is supportive care. Read More

    Poisonous plants: effects on embryo and fetal development.
    Birth Defects Res C Embryo Today 2013 Dec;99(4):223-34
    USDA-Agricultural Research Service, Poisonous Plant Research Laboratory, 1150 East 1400 North, Logan, Utah, 84341.
    Poisonous plant research in the United States began over 100 years ago as a result of livestock losses from toxic plants as settlers migrated westward with their flocks, herds, and families. Major losses were soon associated with poisonous plants, such as locoweeds, selenium accumulating plants, poison-hemlock, larkspurs, Veratrum, lupines, death camas, water hemlock, and others. Identification of plants associated with poisoning, chemistry of the plants, physiological effects, pathology, diagnosis, and prognosis, why animals eat the plants, and grazing management to mitigate losses became the overarching mission of the current Poisonous Plant Research Laboratory. Read More

    Poisonous plants in New Zealand: a review of those that are most commonly enquired about to the National Poisons Centre.
    N Z Med J 2012 Dec 14;125(1367):87-118. Epub 2012 Dec 14.
    National Poisons Centre, University of Otago, PO Box 913, Dunedin, New Zealand.
    Introduction: New Zealand has a number of plants, both native and introduced, contact with which can lead to poisoning. The New Zealand National Poisons Centre (NZNPC) frequently receives enquiries regarding exposures to poisonous plants. Poisonous plants can cause harm following inadvertent ingestion, via skin contact, eye exposures or inhalation of sawdust or smoked plant matter. Read More

    Water hemlock poisoning in cattle: Ingestion of immature Cicuta maculata seed as the probable cause.
    Toxicon 2011 Jan 20;57(1):157-61. Epub 2010 Nov 20.
    USDA ARS Poisonous Plant Research Laboratory, 1150 E. 1400 N., Logan, UT 84341, USA.
    It is well understood that water hemlock tubers are highly toxic to animals and to humans. However, this is the first time that immature seed from (Cicuta maculata) has been implicated in livestock poisoning. Nine mature Hereford cows from a herd of 81 died in northwestern Utah after ingesting immature seed heads of water hemlock (Cicuta maculata) in late summer. Read More

    Poison hemlock-induced respiratory failure in a toddler.
    Pediatr Emerg Care 2009 Nov;25(11):761-3
    Oregon Health and Science University, Oregon Poison Center, Legacy Emmanuel Hospital, Mail Code CB 550, Portland, OR 97239, USA.
    The ingestion of poison hemlock, or Conium maculatum, is described in a 2-year-old boy. He had the onset of abdominal pain and weakness after being fed C. maculatum picked by his sister from the roadside 2 hours earlier. Read More

    Poisoning due to water hemlock.
    Clin Toxicol (Phila) 2009 Apr;47(4):270-8
    Department of Preventive and Social Medicine, National Poisons Centre, University of Otago, Dunedin, New Zealand.
    Introduction: Water hemlock, which encompasses a range of species divided across two genera (Cicuta and Oenanthe), are regarded as being among the most poisonous plants both in North America and in the United Kingdom. Despite their toxicity, the literature consists almost entirely of case reports.

    Aim: The aim of this review is to summarize this literature by covering all aspects of taxonomy and botanical characterization, principal toxins, basic pharmacology including mechanisms of toxicity, and the clinical features, diagnosis, and management of poisoning. Read More

    What killed Socrates? Toxicological considerations and questions.
    Postgrad Med J 2009 Jan;85(999):34-7
    The death of Socrates in 399 BCE, as reported by Plato in the Phaedo, is usually attributed to poisoning with common hemlock. His progressive centripetal paralysis is characteristic of that poison. Socrates is said to have had a prominent loss of sensation extending centrally from his legs, which is not a feature of hemlock poisoning, and he seems not to have had the unpleasant taste or common gastrointestinal effects of that poison. Read More

    [Child poisoning after ingestion of a wild apiaceae: a case report].
    Arch Pediatr 2008 Feb;15(2):139-41
    Service de pédiatrie, centre hospitalier d'Alès, 811 avenue Docteur-Jean-Goubert, 30103 Alès cedex, France.
    Apiaceae family (formerly Umbelliferae) contains several highly toxic species, including Poison Hemlock (Conium maculatum), Water Hemlock (Cicuta virosa) and Hemlock Water Dropwort (Oenanthe crocata) which are the three main poisonous Apiaceae species growing in France. Thinking he was identifying wild carrots, an 11-year-old boy without previous history ingested the root from a wild Apiaceae. One hour later, he was confused, had drowsiness, headache as well as abdominal pain, vomiting and diarrhoea. Read More

    Poison hemlock (Conium maculatum L.).
    Food Chem Toxicol 2004 Sep;42(9):1373-82
    Faculty of Veterinary Science, Department of Botany, Szent István University, 1400 Budapest, Pf. 2. Hungary.
    One of the most poisonous species amongst higher plants is Conium maculatum. It is a very common nitrophile weed species, belonging to the Apiaceae (formerly Umbelliferae) family. It contains some piperidine alkaloids (coniine, N-methyl-coniine, conhydrine, pseudoconhydrine, gamma-coniceine), which are formed by the cyclisation of an eight-carbon chain derived from four acetate units. Read More

    Biomedical applications of poisonous plant research.
    J Agric Food Chem 2004 Jun;52(11):3211-30
    Poisonous Plant Research Laboratory, Agricultural Research Service, US Department of Agriculture, 1150 East 1400 North, Logan, Utah 84341, USA.
    Research designed to isolate and identify the bioactive compounds responsible for the toxicity of plants to livestock that graze them has been extremely successful. The knowledge gained has been used to design management techniques to prevent economic losses, predict potential outbreaks of poisoning, and treat affected animals. The availability of these compounds in pure form has now provided scientists with tools to develop animal models for human diseases, study modes of action at the molecular level, and apply such knowledge to the development of potential drug candidates for the treatment of a number of genetic and infectious conditions. Read More

    A fatal case of apparent water hemlock poisoning.
    Vet Hum Toxicol 2001 Feb;43(1):35-6
    Coroner for the Province of Saskatchewan, Saskatoon, Canada.
    A 14-y-o North American native boy died 20 h after ingesting "wild carrot". He was gathering edible plants with his family on Canadian Thanksgiving. A sample of the plant he ingested couldn't be positively identified but it contained cicutoxin on chromatography. Read More

    Biochemistry of hemlock (Conium maculatum L.) alkaloids and their acute and chronic toxicity in livestock. A review.
    Toxicon 1999 Jun;37(6):841-65
    Laboratorio de Toxicología Veterinaria, Estación Experimental Agropecuaria Balcarce (INTA), Buenos Aires, Argentina.
    The literature on Conium maculatum biochemistry and toxicology, dispersed in a large number of scientific publications, has been put together in this review. C. maculatum is a weed known almost worldwide by its toxicity to many domestic animals and to human beings. Read More

    Lupines, poison-hemlock and Nicotiana spp: toxicity and teratogenicity in livestock.
    J Nat Toxins 1999 Feb;8(1):117-34
    Poisonous Plant Research Laboratory, USDA Agricultural Research Service, Logan, UT 84341, USA.
    Many species of lupines contain quinolizidine or piperidine alkaloids known to be toxic or teratogenic to livestock. Poison-hemlock (Conium maculatum) and Nicotiana spp. including N. Read More

    Water hemlock (Cicuta douglasii) toxicoses in sheep: pathologic description and prevention of lesions and death.
    J Vet Diagn Invest 1996 Oct;8(4):474-80
    USDA, Poisonous Plant Research Lab, Logan, UT 84341, USA.
    Water hemlock causes numerous livestock losses in North America every year. Description of pathologic and serum biochemical changes has been lacking in the literature. Tubers of western water hemlock (Cicuta douglasii) induced excessive salivation, tremors, grand mal seizures, skeletal and cardiac myodegeneration, and death in sheep given 1. Read More

    Acute renal failure due to tubular necrosis caused by wildfowl-mediated hemlock poisoning.
    Ren Fail 1993 ;15(1):93-6
    Department of Nephrology, Regional Hospital, Taranto, Italy.
    We report the clinical and histological findings in patients with acute renal failure caused by the ingestion of wildfowl who had eaten hemlock buds. Neurotoxic effects were accompanied by rhabdomyolysis, myoglobinuria, and acute tubular necrosis. Histological studies showed diffuse degeneration of the tubular epithelium. Read More

    Ultrasound studies of the effects of certain poisonous plants on uterine function and fetal development in livestock.
    J Anim Sci 1992 May;70(5):1639-43
    Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan 84322.
    Ingestion of locoweed (Astragalus spp. and Oxytropis spp.) by pregnant livestock may result in fetal malformations, delayed placentation, reduced placental and uterine vascular development, hydrops amnii, hydrops allantois, abnormal cotyledonary development, interruption of fetal fluid balance, and abortion. Read More

    The effect of natural toxins on reproduction in livestock.
    J Anim Sci 1992 May;70(5):1573-9
    USDA, ARS, Poisonous Plant Research Laboratory, Logan, UT 84321.
    Reproductive efficiency is the most important economic factor in livestock production. Thus, the hypothalamo-pituitary-gonadal regulatory axis, accessory sexual organ functionality, and the complex events involved in fertilization, implantation, and embryonic and fetal development may be sensitive to therapeutic agents, environmental pollutants, and natural toxicants. There are many factors that adversely affect reproduction, one of which is toxic substances in the diets of animals. Read More

    Toxicosis in dairy cattle exposed to poison hemlock (Conium maculatum) in hay: isolation of Conium alkaloids in plants, hay, and urine.
    J Vet Diagn Invest 1992 Jan;4(1):60-4
    California Veterinary Diagnostic Laboratory System-Toxicology Laboratory, University of California, Davis 95616.
    Cattle in two herds developed signs of bloating, increased salivation and lacrimation, depression, respiratory distress, ataxia, and death after ingestion of hay that contained large amounts of poison hemlock (Conium maculatum). Twenty of 30 Angus cows and calves were affected in the first herd (2 died). In the second herd, 5 of 30 Holstein heifers were affected (1 died). Read More

    Clinical spectrum of accidental hemlock poisoning: neurotoxic manifestations, rhabdomyolysis and acute tubular necrosis.
    Nephrol Dial Transplant 1991 ;6(12):939-43
    Division of Internal Medicine, Hospital of Martina Franca, Italy.
    In the past, hemlock poisoning was only known for its neurotoxic effects; quite recently non-neurological features, consisting of rhabdomyolysis and acute renal failure, have been also described. Here we report our experience with these clinical findings, which we frequently observe in accidental hemlock poisoning. Between 1972 and 1990 we studied 18 patients: 17 of them were poisoned by conline (an alkaloid of Conium maculatim) in Apulia (Italy), and one by cicutoxin (the active principle of water hemlock) in New Mexico (USA). Read More

    Congenital skeletal malformations and cleft palate induced in goats by ingestion of Lupinus, Conium and Nicotiana species.
    Toxicon 1990 ;28(12):1377-85
    USDA/ARS/Poisonous Plant Research Laboratory, Logan, UT 84321.
    Three piperidine alkaloid containing plants, Conium maculatum (poison-hemlock), Nicotiana glauca (tree tobacco) and Lupinus formosus (lunara lupine), induced multiple congenital contractures (MCC) and palatoschisis in goat kids when their dams were gavaged with the plant during gestation days 30-60. The skeletal abnormalities included fixed extension or flexure of the carpal, tarsal, and fetlock joints, scoliosis, lordosis, torticollis and rib cage abnormalities. Clinical signs of toxicity included those reported in sheep, cattle and pigs--ataxia, incoordination, muscular weakness, prostration and death. Read More

    Toxicoses in livestock from the hemlocks (Conium and Cicuta spp.).
    J Anim Sci 1988 Sep;66(9):2407-13
    Poisonous Plant Res. Lab., U.S. Department of Agriculture, Logan, UT 84321.
    The hemlocks, Conium maculatum (poison-hemlock) and Cicuta spp. (waterhemlock), are poisonous plants that cause sizeable losss to the livestock industry. Clinical signs of poisonhemlock toxicosis are similar in all species of livestock and include muscular weakness, incordination, trembling, initial central nervous system stimulation, depression and death from respiratory paralysis. Read More

    Maternal and fetal toxicity of poison hemlock (Conium maculatum) in sheep.
    Am J Vet Res 1988 Feb;49(2):281-3
    US Department of Agriculture, Poisonous Plant Research Laboratory, Logan, UT 84321.
    Poison hemlock (Conium maculatum) was toxic to pregnant ewes and their fetuses when fed during gestation days 30 through 60. Maternal effects included trembling, muscular weakness in the neck initially, then progressing to the limbs, ataxia, frequent urination and defecation, and death. Convulsive seizures were not observed. Read More

    Radio ultrasound observations of the fetotoxic effects in sheep from ingestion of Conium maculatum (poison-hemlock).
    J Toxicol Clin Toxicol 1988 ;26(3-4):175-87
    USDA/ARS/Poisonous Plant Research Laboratory, Logan, Utah 84321.
    Fetal movement in pregnant ewes gavaged with Conium maculatum (poison-hemlock) was reduced significantly, but temporarily. Fetal movement was observed by radio ultrasound at 45, 54 and 60 days of gestation in control ewes and on days 45, 54, and 60 of gestation immediately before and 1 hour following poison-hemlock feeding in treated ewes. Fetal movement was significantly reduced (P less than 0. Read More

    Cicuta toxicosis in cattle: case history and simplified analytical method.
    Vet Hum Toxicol 1987 Jun;29(3):240-1
    Poisoning of cattle by water hemlock roots is a common occurrence. The experience of our Pathology Branch has been that the roots will be found in the esophageal groove with no obvious signs of root in the rumen. Confirmation of the presence of cicuta poisoning is done by analysis for cicutoxin in either the roots of the plants on which the animals were grazing or on the root material removed from the esophageal groove. Read More

    Hemlock water dropwort poisoning.
    Postgrad Med J 1987 May;63(739):363-5
    Department of Chemical Pathology, John Radcliffe Hospital, Headington, Oxford, UK.
    Severe plant poisoning is relatively uncommon in adults. We report two adults who ingested hemlock water dropwort roots, having mistaken them for wild parsnip. One developed prolonged convulsions, severe metabolic acidosis and respiratory distress requiring mechanical ventilation. Read More

    Conium maculatum (poison hemlock) toxicosis in a flock of range turkeys.
    Avian Dis 1987 Apr-Jun;31(2):386-8
    Five 20-week-old tom turkeys from a flock of range turkeys were presented for examination; the flock had a history of salivation, tremors, paralysis, and increased mortality. Necropsy revealed numerous seeds identified as seeds from Conium maculatum (poison hemlock) within the crop, proventriculus, and gizzard. Histopathologic alterations were limited to catarrhal enteritis. Read More

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