140 results match your criteria Plant Poisoning Glycosides - Cardiac

Investigation of cardiac glycosides from oleander in a human induced pluripotent stem cells derived cardiomyocyte model.

Toxicol Lett 2021 Oct 8;350:261-266. Epub 2021 Aug 8.

Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstraße 11, 80937, München, Germany. Electronic address:

The ingestion of Nerium oleander and Thevetia peruviana are common causes for poisoning in Southeast Asia. All parts of the oleander shrub contain cardiac glycosides of the cardenolide type. These glycosides act via inhibition of a Na/K-ATPase which might cause severe arrhythmia and subsequent death in oleander-poisoned patients. Read More

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October 2021

Cardiac Glycoside Research?

Toxins (Basel) 2021 05 11;13(5). Epub 2021 May 11.

Department of Biochemistry and Microbiology, University of Chemistry and Technology Prague, Technická 5, Prague 6, Czech Republic.

Cardiac glycosides (CGs), toxins well-known for numerous human and cattle poisoning, are natural compounds, the biosynthesis of which occurs in various plants and animals as a self-protective mechanism to prevent grazing and predation. Interestingly, some insect species can take advantage of the CG's toxicity and by absorbing them, they are also protected from predation. The mechanism of action of CG's toxicity is inhibition of Na/K-ATPase (the sodium-potassium pump, NKA), which disrupts the ionic homeostasis leading to elevated Ca concentration resulting in cell death. Read More

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[A poisonous spring smoothie with wild herbs: accidental intoxication with foxglove (Digitalis purpurea)].

Ned Tijdschr Geneeskd 2020 11 12;164. Epub 2020 Nov 12.

St. Antonius ziekenhuis, afd. Klinische Farmacie,Nieuwegein.

Background: At a time when self-sufficiency and health are becoming increasingly important in society, the chances of intoxications with wild plants are increasing. Foxglove contains poisonous cardiac glycosides such as digoxin, digitoxin and gitoxin. The levels vary greatly and depend on the season and the location of the plants. Read More

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November 2020

Calotropis poisoning with severe cardiac toxicity A case report.

J Family Med Prim Care 2020 Aug 25;9(8):4444-4447. Epub 2020 Aug 25.

Department of Division of Critical Care, Christian Medical College, Vellore, Tamil Nadu, India.

Calotropis is a widely prevalent plant in the Indian Subcontinent. The extract and various parts of the plant are used by traditional healers for treating miscellaneous diseases. All parts of the plants are toxic; there are many case reports of gastrointestinal, cutaneous and ocular toxicity with Calotropis. Read More

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Dose and efficacy of repeated administrations of digoxin-specific antibody fragments: Case report of foxglove poisoning.

Basic Clin Pharmacol Toxicol 2021 Jan 26;128(1):183-186. Epub 2020 Aug 26.

Pharmacy Department, Bretagne Atlantique Hospital, Vannes, France.

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January 2021

Outbreak of Oleander () Poisoning in Dairy Cattle: Clinical and Food Safety Implications.

Toxins (Basel) 2020 07 24;12(8). Epub 2020 Jul 24.

Department of Veterinary Medicine, University of Bari, 70121 Bari, Italy.

Oleander is a spontaneous shrub widely occurring in Mediterranean regions. Poisoning is sporadically reported in livestock, mainly due to the ingestion of leaves containing toxic cardiac glycosides (primarily oleandrin). In this study, 50 lactating Fleckvieh cows were affected after being offered a diet containing dry oleander pruning wastes accidentally mixed with fodder. Read More

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Acute oleander poisoning: A study of clinical profile from a tertiary care center in South India.

J Family Med Prim Care 2020 Jan 28;9(1):136-140. Epub 2020 Jan 28.

Department of Emergency Medicine, Christian Medical College, Vellore, Tamil Nadu, India.

Introduction: Yellow oleander (), which belongs to the Apocyanaceae family, is a common shrub seen throughout the tropics. All parts of the plant contain high concentrations of cardiac glycosides which are toxic to cardiac muscle and the autonomic nervous system. Here, we describe the clinical profile of patients with oleander poisoning and their outcomes. Read More

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January 2020

A Case Report of Accidental Intoxication following Ingestion of Foxglove Confused with Borage: High Digoxinemia without Major Complications.

Case Rep Cardiol 2019 29;2019:9707428. Epub 2019 Nov 29.

Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Via Balzaretti 9, Milan, Italy.

Foxglove ( L.) leaves are frequently confused with borage ( L.), which is traditionally used as a food ingredient. Read More

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November 2019

A Probable Fatal Case of Oleander (Nerium oleander) Poisoning on a Cattle Farm: A New Method of Detection and Quantification of the Oleandrin Toxin in Rumen.

Toxins (Basel) 2019 07 25;11(8). Epub 2019 Jul 25.

Pavia Poison Control Centre-National Toxicology Information Centre, 27100 Pavia, Italy.

Oleander (Nerium oleander) is an ornamental plant common in tropical and sub-tropical regions that is becoming increasingly widespread, even in temperate regions. Oleander poisoning may occur in animals and humans. The main active components contained in the plant are cardiac glycosides belonging to the class of cardenolides that are toxic to many species, from human to insects. Read More

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Cytotoxic saponins and other natural products from flowering tops of Narthecium ossifragum L.

Phytochemistry 2019 Aug 14;164:67-77. Epub 2019 May 14.

Department of Chemistry and Centre for Pharmacy, University of Bergen, Allégt. 41, N-5007 Bergen, Norway. Electronic address:

For more than four centuries, the intake of Narthecium ossifragum has been associated with poisoning in domesticated animals. Saponins occurring in flowering tops of the plant are considered to cause kidney damage in calves. At present, there are more than 30 papers on the saponins of N. Read More

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Cardiac arrhythmias, electrolyte abnormalities and serum cardiac glycoside concentrations in yellow oleander (Cascabela thevetia) poisoning - a prospective study.

Clin Toxicol (Phila) 2019 02 3;57(2):104-111. Epub 2018 Aug 3.

a Department of Emergency Medicine and Trauma , Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) , Puducherry , India.

Background: Consumption of yellow oleander (Cascabela thevetia) is a popular method of intentional self-harm in South India.

Objectives: The objectives of this study were to identify the cardiac arrhythmias and electrolyte abnormalities in yellow oleander poisoning and to identify the association between electrolyte abnormalities, cardiac glycoside concentrations at admission and the severity of cardiotoxicity. This study was also designed to identify clinical and biochemical parameters at presentation which predict serious arrhythmias and determinants of mortality. Read More

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February 2019

An outbreak of poisoning by Kalanchoe blossfeldiana in cattle in northeastern Brazil.

Trop Anim Health Prod 2018 Mar 16;50(3):693-696. Epub 2017 Nov 16.

National Institute for Agriculture Research (INIA), CP 70.000, La Estanzuela, Colonia, Uruguay.

In the world, Kalanchoe species are primarily ornamentals and houseplants, but some have escaped cultivation and can be found in the field. In Latin America, there are no reports of spontaneous poisoning by Kalanchoe species in animals. This study aimed to describe the epidemiological, clinical, and pathological aspects of an outbreak of poisoning by Kalanchoe blossfeldiana in cattle in the semiarid region of Pernambuco, Brazil. Read More

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Letter in response to "fatal cardiac glycoside poisoning due to mistaking foxglove for comfrey".

Clin Toxicol (Phila) 2018 06 2;56(6):447-449. Epub 2017 Nov 2.

c Washington Poison Center, Division of Emergency Medicine, University of Washington , Seattle , WA , USA.

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Successful use of digoxin-specific immune Fab in the treatment of severe Nerium oleander toxicosis in a dog.

J Vet Emerg Crit Care (San Antonio) 2017 Sep 29;27(5):596-604. Epub 2017 Jul 29.

Department of Cardiology, Veterinary Emergency and Critical Care, Las Vegas, NV, 89147.

Objective: To describe a case in which digoxin-specific immune Fab was used successfully in a dog with severe oleander toxicosis secondary to ingesting plant material.

Case Summary: A 6-year-old intact female Rhodesian Ridgeback mixed breed dog was presented for severe oleander toxicosis and was refractory to all antiarrhythmic therapies and supportive care. Digoxin-specific immune Fab was successful in treating this dog. Read More

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September 2017

Fatal cardiac glycoside poisoning due to mistaking foxglove for comfrey.

Clin Toxicol (Phila) 2017 Aug 2;55(7):670-673. Epub 2017 May 2.

b Department of Emergency Medicine , Chang Gung Memorial Hospital, Linkou Branch , Taoyuan , Taiwan.

Context: Accidental ingestion of foxglove (Digitalis purpurea) can cause significant cardiac toxicity. We report a patient who ingested foxglove mistaking it for comfrey and developed refractory ventricular arrhythmias. The patient died despite treatment with digoxin-specific antibody fragments (DSFab) and veno-arterial extracorporeal membrane oxygenation (VA-ECMO). Read More

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In the kingdom of "tortelli" (ravioli-like pasta) plant poisoning is still a threat. A case report of near-fatal poisoning from Digitalis Purpurea accidentally confused with Borago Officinalis.

Acta Biomed 2016 01 16;87(3):353-357. Epub 2016 Jan 16.

University Hospital of Parma, Italy.

A 58 years healthy old woman was admitted to the Emergency Department (ED) with cardiac arrest due to ventricular fibrillation (VF). Appropriate cardiopulmonary resuscitation (CPR), multiple DC shocks and oro-tracheal intubation (OTI) were effective to induce recovery of spontaneous circulation (ROSC). After ROSC was achieved, the electrocardiogram (ECG) showed an idio-ventricular rhythm with atrioventricular dissociation. Read More

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January 2016

Comfrey herbal remedy causing second-degree heart block: do not be outfoxed by digitalis.

BMJ Case Rep 2016 Dec 1;2016. Epub 2016 Dec 1.

Department of Accident and Emergency, King's College Hospital, London, UK.

A previously well woman aged 63 years presents to the emergency department with vomiting, palpitations and 3 presyncopal episodes. She had no previous medical or cardiac history, with the patient stating that she tried a herbal remedy of boiled comfrey leaves for insomnia 18 hours before arrival to the department. Her ECG showed multiple abnormalities, including bradycardia, second-degree atrioventricular node block, Mobitz Type 2, a shortened QT interval, downsloping ST depression and presence of U waves. Read More

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December 2016

Plant-derived cardiac glycosides: Role in heart ailments and cancer management.

Seema Patel

Biomed Pharmacother 2016 Dec 22;84:1036-1041. Epub 2016 Oct 22.

Bioinformatics and Medical Informatics Research Center, San Diego State University, 5500 Campanile Dr San Diego, CA 92182, USA. Electronic address:

Cardiac glycosides, the cardiotonic steroids such as digitalis have been in use as heart ailment remedy since ages. They manipulate the renin-angiotensin axis to improve cardiac output. However; their safety and efficacy have come under scrutiny in recent times, as poisoning and accidental mortalities have been observed. Read More

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December 2016

Oleander Poisoning as an Example of Self-Medication Attempt.

Balkan Med J 2016 Sep 1;33(5):559-562. Epub 2016 Sep 1.

Institute of Forensic Sciences, İstanbul University, Istanbul, Turkey.

Background: There is an increasing interest in herbal products as a self-medication method in recent years. Some plant extracts either turn into drugs over time or are consumed directly without treatment. One of these plants is L. Read More

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September 2016

Potential Health Risks Posed by Plant-Derived Cumulative Neurotoxic Bufadienolides in South Africa.

Christo Botha

Molecules 2016 Mar 16;21(3):348. Epub 2016 Mar 16.

Department of Paraclinical Sciences, Faculty of Veterinary Science, University of Pretoria, Private Bag X05, Onderstepoort 0110, South Africa.

Bufadienolide-type cardiac glycosides have a worldwide distribution and are mainly synthesized by plants, but there are also animal sources. In South Africa, members of three genera of the Crassulaceae (Cotyledon, Tylecodon and Kalanchoe) cause a unique chronic form of cardiac glycoside poisoning, predominantly in small stock. This paretic/paralytic condition is referred to as "krimpsiekte", cotyledonosis or "nenta". Read More

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Silver nanoparticles synthesized from Adenium obesum leaf extract induced DNA damage, apoptosis and autophagy via generation of reactive oxygen species.

Colloids Surf B Biointerfaces 2016 May 18;141:158-169. Epub 2016 Jan 18.

Department of Environment and Forest Resources, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon 34134, Republic of Korea.

Silver nanoparticles (AgNPs) are an important class of nanomaterial used for a wide range of industrial and biomedical applications. Adenium obesum is a plant of the family Apocynaceae that is rich in toxic cardiac glycosides; however, there is scarce information on the anticancer potential of its AgNPs. We herein report the novel biosynthesis of AgNPs using aqueous leaf extract of A. Read More

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A case of Mobitz type II atrioventricular block due to Nerium oleander poisoning successfully managed with digoxin-specific Fab antibody fragments.

Turk Kardiyol Dern Ars 2015 Oct;43(7):648-50

Department of Cardiology, Istanbul Medipol University Faculty of Medicine, Istanbul, Turkey.

Nerium oleander is a popular ornamental plant grown in many tropical and subtropical countries and in the Mediterranean region. It is dangerous because it has been shown to contain several types of cardiac glycosides, and hence can cause cardiac arrhythmias resembling digoxin in their toxicologic manifestations. We report a patient presenting to our hospital with Mobitz type II atrioventricular block after drinking herbal tea prepared from oleander leaves. Read More

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October 2015

Hypoglycemia associated with oleander toxicity in a dog.

C Page R J Murtaugh

J Med Toxicol 2015 Mar;11(1):141-3

Department of Internal Medicine, VCA All-Care Animal Referral Center, 18440 Amistad Street, Fountain Valley, CA, 92708, USA,

Oleander poisoning typically results in cardiac arrhythmias, hyperkalemia, and gastrointestinal irritation, and can be fatal. Oleander extracts have also been studied experimentally as hypoglycemic agents. Here, we describe a dog with confirmed oleander toxicosis presenting with classical symptoms and also hypoglycemia. Read More

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Rapid detection of convallatoxin using five digoxin immunoassays.

Clin Toxicol (Phila) 2014 Aug 1;52(7):659-63. Epub 2014 Jul 1.

Department of Laboratory Medicine, Yale School of Medicine , New Haven, CT , USA.

Context: Cardiac glycosides of plant origin are implicated in toxic ingestions that may result in hospitalization and are potentially lethal. The utility of commonly available digoxin serum assays for detecting foxglove and oleander ingestion has been demonstrated, but no studies have evaluated the structurally similar convallatoxin found in Convallaria majalis (lily of the valley) for rapid laboratory screening, nor has digoxin immune Fab been tested as an antidote for this ingestion.

Objective: We aimed to (1) evaluate multiple digoxin assays for cross-reactivity to convallatoxin, (2) identify whether convallatoxin could be detected in vivo at clinically significant doses, and (3) determine whether digoxin immune Fab could be an effective antidote to convallatoxin. Read More

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Toxicology of some important medicinal plants in southern Africa.

Food Chem Toxicol 2013 Dec 27;62:609-21. Epub 2013 Sep 27.

Research Centre for Plant Growth and Development, School of Life Sciences, University of KwaZulu-Natal Pietermaritzburg, Private Bag X01, Scottsville 3201, South Africa.

Africa is home to two major floral kingdoms: the Paleotropical kingdom of central Africa and the Capensis kingdom of the Western Cape province of South Africa, the latter of which consists of approximately 10,000 species, representing about 20% of Africa's floral 'gold mine', better known as the Cape herbal medicine. Needless to say, such rich flora comes with numerous plants with a potential to cause poisoning to humans. This review document reports important toxic medicinal plants and their toxic ingredients for plant species resident in the southern African region. Read More

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December 2013

What toxicity may result from ingestion of the plant pictured below? Answer: cardioactive steroid toxicity from common milkweed.

J Med Toxicol 2013 Sep;9(3):287-8

Department of Emergency Medicine, Hennepin County Medical Center, 701 Park Ave, Minneapolis, MN, 55415, USA.

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September 2013

A case of Nerium oleander toxicity: a thorny predicament.

Psychosomatics 2013 Jul-Aug;54(4):379-81. Epub 2012 Dec 27.

Creighton University School of Medicine at St. Joseph's Hospital and Medical Center, Phoenix, AZ 85013, USA.

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February 2014