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Immunohorizons 2022 Jun 24;6(6):384-397. Epub 2022 Jun 24.

Department of Microbiology & Immunology, McGill University, Montreal, Quebec, Canada;

Inactivated influenza vaccines have struggled to provide consistent protection in older individuals. Circumventing immune senescence, an aging of the immune response characterized by weak humoral responses to vaccines, and unchecked inflammation during infection require novel immunization strategies. Plant-based virus-like particles (VLPs) bearing recombinant hemagglutinin proteins have been shown to provide protection in older animals in preclinical challenge studies, despite eliciting relatively low or absent humoral responses. Read More

J Genet Genomics 2022 Jun 21. Epub 2022 Jun 21.

School of Life Sciences, Institute of Life Sciences and Green Development, Hebei University, Baoding, Hebei 071000, China. Electronic address:

Pan-genomics can encompass most of the genetic diversity of a species or population and has proved to be a powerful tool for studying genomic evolution and the origin and domestication of species, and for providing information for plant improvement. Plant genomics has greatly progressed because of improvements in sequencing technologies and the rapid reduction of sequencing costs. Nevertheless, pan-genomics still presents many challenges, including computationally intensive assembly methods, high costs with large numbers of samples, ineffective integration of big data, and difficulty in applying it to downstream multi-omics analysis and breeding research. Read More

Environ Pollut 2022 Jun 21:119661. Epub 2022 Jun 21.

State Key Laboratory of Grassland Agroecosystems, College of Ecology, Lanzhou University, Lanzhou, 730000, China. Electronic address:

Nanoscale zero-valent iron (nZVI) might generate positive and negative effects on plant growth, since it acts as either hazardous or growth-promotion role. It is still unclear whether such dual roles can be mediated by arbuscular mycorrhizal fungifungi (AMF) in plant-AMF symbiosis. We first identified that in 1. Read More

Pharmacol Res 2022 Jun 21:106322. Epub 2022 Jun 21.

Integrative Neurobiology Section and. Electronic address:

Recent studies have proposed that heteromers of µ-opioid receptors (MORs) and galanin Gal receptors (GalRs) localized in the mesencephalon mediate the dopaminergic effects of opioids. The present study reports converging evidence, using a peptide-interfering approach combined with biophysical and biochemical techniques, including total internal reflection fluorescence microscopy, for a predominant homodimeric structure of MOR and GalR when expressed individually, and for their preference to form functional heterotetramers when co-expressed. Results show that a heteromerization-dependent change in the GalR homodimeric interface leads to a switch in G-protein coupling from inhibitory Gi to stimulatory Gs proteins. Read More

Plant Sci 2022 Jun 21:111348. Epub 2022 Jun 21.

INFIVE, Facultades de Ciencias Agrarias y Forestales y Ciencias Naturales y Museo, Universidad Nacional de La Plata-CCT CONICET La Plata, Argentina. Electronic address:

Increased synthesis of HO is observed during the initiation of fruit ripening. However, its association with plant cell processes triggering the maturation of fruit has not yet been demonstrated. The aim of this work is to investigate whether HO participates in the tomato ripening process and particularly through its association with the ethylene signaling pathway. Read More

Plant Sci 2022 Jun 21:111363. Epub 2022 Jun 21.

College of Food, Shenyang Agricultural University, No.120 Dongling Road, Shenhe District, Shenyang City 110866, People's Republic of China. Electronic address:

Cold-stored 'Nanguo' pears are susceptible to peel browning during subsequent shelf life. In this study, 'Nanguo' pears were cold-stored for different periods to elucidate the metabolism of phenylpropanoid accompanying browning. Changes in phenolics and flavonoids and the crucial enzyme activity and related gene expression involved in the phenylpropanoid pathway were monitored. Read More

J Adv Res 2022 Jun 21. Epub 2022 Jun 21.

State Key Laboratory for Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address:

Introduction: Acute myocardial infarction (AMI) accounts for the majority of deaths caused by coronary artery disease (CAD). Early warning of AMI, especially for patients with stable coronary artery disease (sCAD), is urgently needed. Our previous study showed that alterations in the gut microbiota were correlated with CAD severity. Read More

Eur J Pharmacol 2022 Jun 21:175113. Epub 2022 Jun 21.

Department of Science in Korean Medicine, Kyung Hee University, 24 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, Republic of Korea. Electronic address:

Withaferin A (WFA), a withanolide, is isolated from plants of Withania somnifera (L.) Dual (Solanaceae), known as Indian ginseng, Indian winter cherry or Ashwagandha. It has been reported to exert multifaceted anti-neoplastic effects. Read More

Chemosphere 2022 Jun 21:135427. Epub 2022 Jun 21.

MOE Key Laboratory of Environmental Remediation and Ecological Health, College of Environmental and Resource Science, Zhejiang University, Hangzhou, 310058, China. Electronic address:

The toxic chemical element cadmium (Cd) in paddy fields triggered increasing problems of growth inhibition and food security in rice consistently. In this study, we found Metarhizium robertsii, which is widely used as a bioinsecticide and biofertilizer in agriculture and recently found to be resistant to Cd, developed intraradical and extraradical symbiotic hyphae in rice seedlings, and successfully colonized in the rice rhizosphere soil to more than 10 CFUs g soil at harvesting. M. Read More

Chemosphere 2022 Jun 21:135413. Epub 2022 Jun 21.

Univ. Lille, CNRS, UMR 8516 - LASIRE, Laboratoire Avancé de Spectroscopie pour les Interactions, la Réactivité et l'Environnement F-59000 Lille, France.

Increase of water quality in aquatic systems has become a hot button issue in recent decades. However, with the aim to implement an effective remediation strategy, the first step is to identify the sources of diffuse and point-source pollution using several tracers. In urban areas, B isotopes, Gd enrichment, Cl or carbamazepine concentrations can be used as wastewater treatment plant tracers. Read More

Chemosphere 2022 Jun 21:135438. Epub 2022 Jun 21.

CAS Key Laboratory of Crust-Mantle Materials and Environment, School of Earth and Space Sciences, University of Science and Technology of China, Hefei, Anhui, 230026, China; Department of Soil and Environmental Sciences, Muhammad Nawaz Shareef University of Agriculture, Multan, 60000, Pakistan.

The presence of excessive hexavalent chromium (Cr(VI)) in the contaminated soils and plants has become a global environmental issue due to its toxicity and carcinogenicity. This work investigated the feasibility of immobilizing Cr(VI) in the soil-plant environment using calcium silicate hydrate (C-S-H) synthesized from coal gangue. The results revealed that the C-S-H amendment increased soil pH and organic matter (OM), which further promoted Cr(VI) immobilization. Read More

Chemosphere 2022 Jun 21:135417. Epub 2022 Jun 21.

School of Environment, Guangdong Provincial Key Laboratory of Chemical Pollution and Environmental Safety & MOE Key Laboratory of Theoretical Chemistry of Environment, South China Normal University, Guangzhou, 510006, China.

Chlorine disinfection is widely applied in drinking water treatment plant to inactivate pathogens in drinking water, but it unintentionally reacts with organic matter present in source waters and generates halogenated disinfection byproducts (DBPs). Sugar is one of the most commonly used seasoning in our diet. The addition of sugar could significantly improve the taste of the beverages; however, the effects of sugar on DBP formation and transformation remain unknown. Read More

Chemosphere 2022 Jun 21:135403. Epub 2022 Jun 21.

Key Laboratory of Integrated Regulation and Resource Development on Shallow Lake of Ministry of Education, College of Environment, Hohai University, Nanjing, 210098, China; Yangtze Institute for Conservation and Development, Hohai University, Jiangsu, 210098, China. Electronic address:

Microbiomes are vital in promoting nutrient cycling and plant growth in soil ecosystems. However, microbiomes face adverse effects from multiple persistent pollutants, including per- and poly-fluoroalkyl substances (PFASs). PFASs threaten the fertility and health of soil ecosystems, yet the response of microbial community stability and trophic transfer efficiencies to PFASs is still poorly understood. Read More

Sci Total Environ 2022 Jun 21:156863. Epub 2022 Jun 21.

CAS Key Laboratory of Tropical Forest Ecology, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Menglun, Yunnan 666303, China; National Field Scientific Observation and Research Station of Forest Ecosystem in Ailao Mountain, Yunnan 665000, China. Electronic address:

The concept of microbial functional genes has added a new dimension in microbial ecology research by improving the model of microbial community-ecosystem functions relationship. However, our knowledge vis-à-vis fine-scale spatial distribution pattern of functional genes and their probable impact on plant community in the hyper-diverse tropical forest ecosystem is very limited. Here, we investigated the spatial pattern of functional genes abundance (NirK, AOA, AOB, and PhoD), identified key influencing factors, and distinguished the key functional group supporting the plant community in a tropical rainforest located in Xishuangbanna. Read More

Sci Total Environ 2022 Jun 21:156852. Epub 2022 Jun 21.

Area of Ecology, Department of Biodiversity and Environmental Management, Faculty of Biological and Environmental Sciences, University of León, 24071 León, Spain.

Remote sensing techniques are of particular interest for monitoring wildfire effects on soil properties, which may be highly context-dependent in large and heterogeneous burned landscapes. Despite the physical sense of synthetic aperture radar (SAR) backscatter data for characterizing soil spatial variability in burned areas, this approach remains completely unexplored. This study aimed to evaluate the performance of SAR backscatter data in C-band (Sentinel-1) and L-band (ALOS-2) for monitoring fire effects on soil organic carbon and nutrients (total nitrogen and available phosphorous) at short term in a heterogeneous Mediterranean landscape mosaic made of shrublands and forests that was affected by a large wildfire. Read More

Sci Total Environ 2022 Jun 21:156817. Epub 2022 Jun 21.

College of Coastal Agricultural Sciences, School of Chemistry and Environment, Guangdong Ocean University, Zhanjiang 524088, China; Shenzhen Research Institute of Guangdong Ocean University, Shenzhen 518108, China. Electronic address:

Soil salinization has been recognized as one of the main factors causing the decrease of cultivated land area and global plant productivity. Application of salt tolerant plants and improvement of plant salt tolerance are recognized as the major routes for saline soil restoration and utilization. Sea rice 86 (SR86) is known as a rice cultivar capable of growing in saline soil. Read More

Environ Res 2022 Jun 21:113741. Epub 2022 Jun 21.

College of Environment and Resources, Xiangtan University, Xiangtan, 411105, China. Electronic address:

The generic of antibiotics is considered to be a main reason for the generation of antibiotic resistance genes (ARGs) in wastewater treatment plants (WWTPs). However, little has been reported about the antibiotic biosynthesis by activated sludge. In this study, the distribution and expression of antibiotic biosynthetic genes (ABGs) in the floc sludge and biofilm from two WWTPs were deciphered using metagenomics and metatranscriptomics. Read More

Int J Biol Macromol 2022 Jun 21. Epub 2022 Jun 21.

Joint Laboratory of Advanced Biomedical Materials (NFU-UGent), Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University (NFU), Nanjing 210037, China. Electronic address:

Herein, a biomass-derived compound Z1 is synthesized via 'one pot' method for detection Pb using fluorescence and visual dual-mode in aqueous solution. Z1 shows good response to Pb with a limit of detection (LOD) of 13.4 nM. Read More

Cell 2022 Jun;185(13):2208-2209

Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada; Department of Botany, University of British Columbia, Vancouver, BC V6T 1Z4, Canada. Electronic address:

Plant immune receptors often contain TIR domains, which can oligomerize to form active enzyme complexes in response to pathogen infections. In this issue of Cell, Yu and colleagues discover that some plant TIR domains possess a novel 2',3'-cAMP/cGMP synthetase activity that cleaves double-stranded RNA/DNA, triggering cell death during plant immune responses. Read More

Biomed Pharmacother 2022 Jun 21;153:113299. Epub 2022 Jun 21.

Poona College of Pharmacy, Department of Pharmaceutical Chemistry, Bharati Vidyapeeth (Deemed to be University), Erandwane, Pune 411038, Maharashtra, India. Electronic address:

Neurodegenerative diseases and various other chronic ailments have gradually transformed into public-health issues. Neurodegenerative disorders are a range of progressive neural abnormalities characterized by cellular dysfunctions, neuronal structure, and function loss. Among many chronic disorders, oxidative stress, inflammation, mitochondrial dysregulation, and cellular alterations in the human body are considered the most prevalent diagnostic symptoms. Read More

Plant Physiol Biochem 2022 Jun 18;185:336-343. Epub 2022 Jun 18.

Key Laboratory of Ecology of Rare and Endangered Species and Environmental Protection (Guangxi Normal University), Ministry of Education, China. Electronic address:

To investigate the effect of potassium application on cotton damage mitigation after waterlogging stress, experiments were conducted under two potassium application levels (0 and 150 kg KO hm) with three types of soil waterlogging treatments (0d, 3d and 6d) during cotton flowering stage. The results showed that: (a) under simple soil waterlogging stress, the increments of endogenous hormones contents of IAA, GA and ZR in cotton leaves were decreased as days of soil waterlogging. On the contrary, the soluble protein, MDA and ABA contents were significantly increased, while ZR/ABA, IAA/ABA and GA/ABA were decreased. Read More

Eur J Med Chem 2022 Jun 14;239:114532. Epub 2022 Jun 14.

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming, 650201, China. Electronic address:

Dearomatized isoprenylated acylphloroglucinols (DIAPs) are specific natural products mainly distributed in the plants of genus Hypericum. In this study, guided by HPLC-UV screening, 46 DIAPs (approximately 70% of all DIAPs) including 20 new ones and an unprecedented architecture, were discovered from the roots of Hypericum henryi, which were elucidated by comprehensive spectroscopic, X-ray crystallography, and ECD methods. Compounds 1-7, 39, and 41-42 exhibited remarkable cytotoxicities (IC = 0. Read More

J Plant Physiol 2022 Jun 3;275:153743. Epub 2022 Jun 3.

Canadian Grain Commission, Grain Research Laboratory, 1404-303 Main Street, Winnipeg, Manitoba, R3C 3G8, Canada; Department of Food and Human Nutritional Sciences, 209 - 35 Chancellor's Circle, University of Manitoba, Winnipeg, Manitoba, R3T 2N2, Canada. Electronic address:

Wheat remains a critical global food source, pressured by climate change and the need to maximize yield, improve processing and nutritional quality and ensure safety. An enormous amount of research has been conducted to understand gluten protein composition and structure in relation to end-use quality, yet progress has become stagnant. This is mainly due to the need and inability to biochemically characterize the intact functional glutenin polymer in order to correlate to quality, necessitating reduction to monomeric subunits and a loss of contextual information. Read More

Ultrason Sonochem 2022 Jun 17;88:106070. Epub 2022 Jun 17.

Food Processing Business Incubation Centre, National Institute of Food Technology, Entrepreneurship and Management - Thanjavur, India; Centre of Excellence in Non-Thermal Processing, National Institute of Food Technology, Entrepreneurship and Management - Thanjavur, India. Electronic address:

This study reports the development of non-dairy functional beverage emulsion employing ultrasound (US) of 20 kHz at 130 W and 195 W at processing times of 2 to 8 min using chickpea milk extract and bioactive, flaxseed oil (4%). The pre-emulsion was formed with high shear homogenizer followed by main sonication process. The sonicated emulsions were stored at 4 ± 2 °C till 14 days and characterized for physicochemical and functional properties. Read More

J Environ Radioact 2022 Jun 21;251-252:106949. Epub 2022 Jun 21.

Faculty of Engineering, Kitami Institute of Technology, Kitami, 0908507, Japan. Electronic address:

We measured dissolved radiocesium (Cs and Cs) in surface seawater collected in the western subarctic area of the North Pacific Ocean, Bering Sea, and Arctic Ocean in 2019 and 2020. The radiocesium released from the accident of the Fukushima Dai-ichi nuclear power plant (FNPP1) in 2011 was still observed in these areas (∼2 Bq m decay-corrected to the date of the accident). In 2019/2020, the FNPP1-derived radiocesium concentrations in the Bering Sea and the Chukchi Sea, which is a marginal sea of the Arctic Ocean connecting the Bering Sea to the Arctic Ocean, were within the range of those observed in 2017/2018. Read More

Int J Food Microbiol 2022 Jun 10;378:109784. Epub 2022 Jun 10.

Department of Veterinary Sciences, University of Turin, Largo Braccini 2, Grugliasco, 10095 Turin, Italy.

Listeria monocytogenes is considered a major challenge for the food industry as it can persist for long periods in food processing plants by forming biofilms. The aims of this study were: i) to assess the biofilm producing ability of 57 Listeria monocytogenes isolates previously subjected to whole-genome sequencing (WGS); ii) to compare the levels of biofilm formation with the presence or absence of biofilm associated genes. To determine the presence or absence of a known set of biofilm associated genes, a comparative genomic analysis was performed on each strain. Read More

Carbohydr Res 2022 Jun 16;519:108624. Epub 2022 Jun 16.

Division of Applied Chemistry and Biochemistry, National Institute of Technology, Tomakomai College, Nishikioka 443, Tomakomai, Hokkaido, 059-1275, Japan.

Glycopolypeptide-immobilized particulates exhibit high binding selectivities and affinities for several analytes. However, to date, the conditions for the synthesis of glycopolypeptide-immobilized particulates have not been optimized and the application of these particulates as carriers for affinity chromatography has not been reported. Accordingly, herein, as a model compound for determining the optimal conditions for the immobilization of an artificial glycopolymer on hexyl-containing hybrid silica particulates (HSPs), the glycopolypeptide poly [GlcNAcβ1,4GlcNAc-β-NHCO-(CH)NH-/CH(CH)NH-/γ-PGA] (3) containing multivalent chitobiose moieties and multivalent decyl groups with a γ-polyglutamic acid backbone was synthesized. Read More

J Hazard Mater 2022 Jun 8;437:129323. Epub 2022 Jun 8.

Center for Sustainable Environment Research, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea; Graduate School of Energy and Environment, Korea University, Seoul 02841, Republic of Korea. Electronic address:

Accidental chemical leaks and illegal chemical discharges are a global environmental issue. In 2012, a hydrogen fluoride leak in Gumi, South Korea, killed several people and contaminated the environment. This leak also led to a significant decline in crop yield, even after the soil concentration of hydrogen fluoride decreased to below the standard level following natural attenuation. Read More

Microbiol Res 2022 Jun 17;262:127094. Epub 2022 Jun 17.

Mohammed VI Polytechnic University - AgroBioSciences - Plant & Soil Microbiome Sub-Program, Laboratory of Plant-Microbe Interactions, Ben Guerir 43150, Morocco. Electronic address:

Rhizosphere microbes significantly enhance phosphorus (P) availability from a variety of unavailable P pools in agricultural soils. However, little is known about the contribution of root-associated microorganisms, notably P solubilizing bacteria (PSB), to enhance the use of polyphosphate (PolyP) fertilizers as well as the key mechanisms involved. This study assesses the ability of four PSB (Bacillus siamensis, Rahnella aceris, Pantoea hericii, Bacillus paramycoides) and their consortium (Cs) to enhance the release rate of available P from two types of PolyP ("PolyB" and "PolyC") with a focus on the key role of phosphatase enzyme activities and organic acids production. Read More

Bioorg Chem 2022 Jun 17;127:105973. Epub 2022 Jun 17.

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, Yunnan, China. Electronic address:

Scopariusicides D-M (1-10), ten new ent-clerodane-based meroditerpenoids with a cyclobutane-fused γ/δ-lactone core, were isolated from Isodon scoparius. Their structures were determined by comprehensive analysis of spectroscopic data, single-crystal X-ray diffraction, chemical transformation, and TDDFT ECD calculation. A plausible biosynthetic pathway of 1-10 was proposed in which the asymmetrical cyclobutane ring was formed via a crossed "head-to-tail" intermolecular [2 + 2] cycloaddition in anti/syn facial approaches between an ent-clerodane lactone and a cis-4-hydroxycinnamic acid. Read More