127 results match your criteria Plant Poisoning Alkaloids - Tropane

Large outbreak of Jimsonweed (Datura stramonium) poisoning due to consumption of contaminated humanitarian relief food: Uganda, March-April 2019.

BMC Public Health 2022 03 30;22(1):623. Epub 2022 Mar 30.

Division of Global Health Protection, Center for Global Health, US Centers for Disease Control and Prevention, Atlanta, GA, USA.

Background: Jimsonweed (Datura stramonium) contains toxic alkaloids that cause gastrointestinal and central nervous system symptoms when ingested. This can be lethal at high doses. The plant may grow together with leguminous crops, mixing with them during harvesting. Read More

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Emerging tropane alkaloid contaminations under climate change.

Trends Plant Sci 2021 11 26;26(11):1101-1103. Epub 2021 Aug 26.

Department of Integrative Zoology, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria.

Climate-driven invasions of toxin-producing plants compromise human health, food safety, and food security. A recent poisoning that involved cereal products distributed by the World Food Programme revealed contamination with tropane alkaloids from seeds of invasive common thorn-apple. With continued global change, plant toxin contaminations could become a more widespread phenomenon. Read More

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November 2021

Tropane alkaloid contamination of agricultural commodities and food products in relation to consumer health: Learnings from the 2019 Uganda food aid outbreak.

Compr Rev Food Sci Food Saf 2021 01 10;20(1):501-525. Epub 2020 Nov 10.

School of Biological Sciences, Institute for Global Food Security, Queen's University Belfast, Belfast, UK.

Tropane alkaloids (TAs) are secondary plant metabolites derived mainly from Solanaceae plant families, with the most virulent invasive species being Datura stramonium. Datura stramonium commonly grows in cereal fields and produce TAs (e.g. Read More

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January 2021

A plant-derived cocaine hydrolase prevents cocaine overdose lethality and attenuates cocaine-induced drug seeking behavior.

Prog Neuropsychopharmacol Biol Psychiatry 2020 08 6;102:109961. Epub 2020 May 6.

School of Life Sciences, Arizona State University, Tempe, AZ 85287-4501, USA; Center of Immunotherapy, Vaccines, and Virotherapy, Biodesign Institute, Arizona State University, Tempe, AZ 85287-4501, USA. Electronic address:

Cocaine use disorders include short-term and acute pathologies (e.g. overdose) and long-term and chronic disorders (e. Read More

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Surviving chlormequat poisoning - pharmacokinetics and the role of atropine.

Clin Toxicol (Phila) 2021 01 27;59(1):74-76. Epub 2020 Apr 27.

Division of Clinical Toxicology and Poison Control Centre Munich, Department of Internal Medicine II, School of Medicine, Technical University of Munich, Munich, Germany.

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January 2021

Common anticholinergic solanaceaous plants of temperate Europe - A review of intoxications from the literature (1966-2018).

Toxicon 2020 Apr 13;177:52-88. Epub 2020 Feb 13.

Faculty of Pharmacy, University of Ljubljana, Tržaška Cesta 32, 1000, Ljubljana, Slovenia.

Datura stramonium, Atropa belladonna, Hyoscyamus niger, and Scopolia carniolica are all temperate plants from the family Solanaceae, which as a result of their anticholinergic tropane alkaloids, hyoscyamine/atropine and scopolamine, have caused many cases of poisoning around the world. Despite the danger these nightshade plants represent, the literature often presents incomplete cases lacking in details and filled with ambiguity, and reviews on the topic tend to be limited in scope. Many also point to a gap in knowledge of these plants among physicians. Read More

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Remember Atropine for "Killer B's".

J Emerg Med 2019 11;57(5):731

Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, Groningen, Netherlands.

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November 2019

Clinical and pathological comparison of Astragalus lentiginosus and Ipomoea carnea poisoning in goats.

Toxicon 2019 Dec 19;171:20-28. Epub 2019 Sep 19.

USDA-ARS Poisonous Plant Research Laboratory, 1150 E. 1400 N, Logan, UT, USA, 84341.

The indolizidine alkaloid swainsonine, found in some Astragalus and Oxytropis (i.e., locoweed) species, is a potent cellular glycosidase inhibitor that often poisons livestock. Read More

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December 2019

Urine tropenol ester levels in workers handling tiotropium bromide synthesis: implications for exposure prevention and biomonitoring.

Arh Hig Rada Toksikol 2019 Jun;70(2):118-122

Institute of Occupational, Social and Environmental Medicine, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

Tropenol ester is a highly toxic anticholinergic substance and an intermediate used in industrial production of the bronchodilator tiotropium bromide. The aim of this study was to systematically test workers involved in its production for tropenol ester in urine to identify any exposure pathways and define additional preventive measures. Twelve workers performing tasks involving potential exposure to tropenol ester were repeatedly monitored at the end of each production cycle. Read More

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Alkaloid chemodiversity in Mandragora spp. is associated with loss-of-functionality of MoH6H, a hyoscyamine 6β-hydroxylase gene.

Plant Sci 2019 Jun 20;283:301-310. Epub 2019 Mar 20.

Department of Vegetable Crops, Newe Ya'ar Research Center, Agricultural Research Organization, P.O. Box 1021, Ramat Yishay 30095, Israel. Electronic address:

Mandrakes (Mandragora spp., Solanaceae) are known to contain tropane alkaloids and have been used since antiquity in traditional medicine. Tropane alkaloids such as scopolamine and hyoscyamine are used in modern medicine to treat pain, motion sickness, as eye pupil dilators and antidotes against organo-phosphate poisoning. Read More

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Neurological syndrome in goats associated with Ipomoea trifida and Ipomoea carnea containing calystegines.

Toxicon 2019 Jan 14;157:8-11. Epub 2018 Nov 14.

Facultad de Veterinaria, Universidad de León, Campus de Vegazana, León, Spain.

A disease characterized by ataxia, tremors and nystagmus had been observed in goats in Nicaragua. The main histologic lesions were loss and neuronal vacuolation of Purkinje cells and Wallerian-like degeneration mainly in the cerebellum, suggesting a glycoprotein storage disease. Ipomoea carnea and Ipomoea trifida found in the paddocks were negative for swainsonine, but contained calystegines at 0. Read More

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January 2019

Simultaneous quantification of atropine and scopolamine in infusions of herbal tea and Solanaceae plant material by matrix-assisted laser desorption/ionization time-of-flight (tandem) mass spectrometry.

Rapid Commun Mass Spectrom 2018 Nov;32(22):1911-1921

Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany.

Rationale: Atropine (Atr) and scopolamine (Scp) are toxic secondary plant metabolites of species within the Solanaceae genus that can accidentally or intentionally reach the food store chain by inaccurate harvesting of any plant material, e.g. for herbal tea infusions. Read More

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November 2018

Worldwide Occurrence and Investigations of Contamination of Herbal Medicines by Tropane Alkaloids.

Thomas Y K Chan

Toxins (Basel) 2017 09 15;9(9). Epub 2017 Sep 15.

Division of Clinical Pharmacology and Drug and Poisons Information Bureau, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China.

Tropane alkaloids occur mainly in plants. In the present review, the main objective is to describe the worldwide occurrence and investigations of anticholinergic poisoning due to the contamination of herbal teas and herbs by tropane alkaloids. Tropane alkaloid poisoning can occur after consumption of any medicinal plant if plants or plant parts are present as contaminants. Read More

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September 2017

Identification of Datura Species Involved in a Food-Poisoning Case Using LC-MS/MS and DNA Barcording.

Shokuhin Eiseigaku Zasshi 2017 ;58(2):86-95

Kawasaki City Institute for Public Health.

A food-poisoning case due to eating the roots of Datura occurred in Kawasaki City, Japan in 2014. The Datura plant was mistakenly collected instead of burdock in a domestic garden. The roots of these plants are quite similar to each other. Read More

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Maternal Ingestion of Ipomoea carnea: Effects on Goat-Kid Bonding and Behavior.

Toxins (Basel) 2016 Mar 16;8(3). Epub 2016 Mar 16.

Research Center of Veterinary Toxicology (CEPTOX), Department of Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo, Pirassununga 13635-900, Brazil.

Ipomoea carnea is a toxic plant found in Brazil and other tropical and subtropical countries and often causes poisoning of livestock. The plant contains the alkaloids swainsonine and calystegines, which inhibit key cellular enzymes and cause systematic cell death. This study evaluated the behavioral effects of prenatal ingestion of this plant on dams and their kids. Read More

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Accidental overdose in the deep shade of night: a warning on the assumed safety of 'natural substances'.

BMJ Case Rep 2015 Nov 5;2015. Epub 2015 Nov 5.

Adult Intensive Care Department, Oxford University Hospitals NHS Trust, Oxford, UK.

There is an increasing use of herbal remedies and medicines, with a commonly held belief that natural substances are safe. We present the case of a 50-year-old woman who was a trained herbalist and had purchased an 'Atropa belladonna (deadly nightshade) preparation'. Attempting to combat her insomnia, late one evening she deliberately ingested a small portion of this, approximately 50 mL. Read More

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November 2015

Black henbane and its toxicity - a descriptive review.

Avicenna J Phytomed 2014 Sep;4(5):297-311

Medical Toxicology Research Centre, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, I. R. Iran.

Black henbane (BH) or Hyoscyamus niger, has been used as a medicine since last centuries and has been described in all traditional medicines. It applies as a herbal medicine, but may induce intoxication accidentally or intentionally. All part of BH including leaves, seeds and roots contain some alkaloids such as Hyoscyamine, Atropine, Tropane and Scopolamine. Read More

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September 2014

Intoxication by angel's trumpet: case report and literature review.

BMC Res Notes 2014 Aug 20;7:553. Epub 2014 Aug 20.

Department of Neurology, CHA Bundang Medical Center, CHA University, 59 Yatap-ro, Bundang-gu, Seongnam-si, Gyeonggi-do 463-712, South Korea.

Background: Brugmansia, commonly referred to as angel's trumpet (AT), has been become popular in Korea as an ornamental shrub. However, it is not generally known by the public that this plant contains tropane alkaloids, and that ingestion of AT can lead to anticholinergic poisoning.

Case Presentation: A 64-year-old Korean female presented with acute mental changes caused by inadvertent ingestion of the petals of AT flowers used as a garnish in a traditional Korean food (bibimbop). Read More

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Toxicological findings in a fatal multidrug intoxication involving mephedrone.

Forensic Sci Int 2014 Oct 6;243:68-73. Epub 2014 May 6.

Centro Regionale Antidoping "A. Bertinaria" - Laboratorio Regionale di Tossicologia, Regione Gonzole 10/1, Orbassano, Turin 10043, Italy; Dipartimento di Chimica, Università degli Studi di Torino, via P. Giuria 7, Turin 10125, Italy.

The distribution of mephedrone in the body fluids and tissues of a subject found dead after the concomitant intake of cocaine and mephedrone is reported. Mephedrone (4-methylmethcathinone) is a designer drug of the phenethylamine family that is able to cause central nervous system stimulation, psychoactivity and hallucinations and that is becoming popular among youth as a recreational drug. Mephedrone has been available in Europe since 2007, and it is sold through the internet and by local shops as bath salt or plant food. Read More

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October 2014

[Acute intoxication in adults - what you should know].

Th Zilker

Dtsch Med Wochenschr 2014 Jan 3;139(1-2):31-46; quiz 43-6. Epub 2014 Jan 3.


Ingestion of household products and plants are the leading cause for calls to the poison control centres as far as children are involved. Severe intoxication in children has become infrequent due to childproofed package and blister packs for drugs. Chemical accidents in adults give rise to hospital admission in only 5 %. Read More

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January 2014

Belladonna Alkaloid Intoxication: The 10-Year Experience of a Large Tertiary Care Pediatric Hospital.

Am J Ther 2016 Jan-Feb;23(1):e74-7

1Division of Pediatric Emergency Medicine, Department of Pediatrics, Dana-Dwek Children Hospital, Tel Aviv University, Tel Aviv, Israel; 2Division of Clinical Pharmacology and Toxicology, Ichilov Hospital, Tel Aviv University, Tel Aviv, Israel; and 3Division of Pediatric Emergency Medicine, Department of Pediatrics, and 4Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, University of Toronto, Ontario, Canada.

The belladonna alkaloids can be isolated from a number of plants, which contain hallucinogens that represent a serious danger to infants, children, and adolescents. Roots, leaves, and fruits of the plant contain the alkaloids atropine, hyoscyamine, and scopolamine, which can lead to an anticholinergic toxidrome; however, not all characteristics of the toxidrome are necessarily present in each case of poisoning. A retrospective chart review of all children seen following anticholinergic ingestions, between April 2001 and November 2010, at the Hospital for Sick Children in Toronto. Read More

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October 2016

Simultaneous detection of 22 toxic plant alkaloids (aconitum alkaloids, solanaceous tropane alkaloids, sophora alkaloids, strychnos alkaloids and colchicine) in human urine and herbal samples using liquid chromatography-tandem mass spectrometry.

J Chromatogr B Analyt Technol Biomed Life Sci 2013 Dec 22;942-943:63-9. Epub 2013 Oct 22.

Hospital Authority Toxicology Reference Laboratory, Princess Margaret Hospital, Hong Kong.

A liquid chromatography-tandem mass spectrometry method for simultaneous detection of 22 toxic plant alkaloids, including aconitum alkaloids and their hydrolyzed products (aconitine, hypaconitine, mesaconitine, yunaconitine, crassicauline A, benzoylaconine, benzoylmesaconine, benzoylhypaconine, deacetylyunaconitine, deacetylcrassicauline A), solanaceous tropane alkaloids (atropine, anisodamine, scopolamine, anisodine), sophora alkaloids (matrine, sophoridine, oxymatrine, cytisine, N-methylcytisine), strychnos alkaloids (brucine, strychnine) and colchicine, in herbal and urine samples was developed and validated. Following sample preparation by liquid-liquid extraction, chromatographic separation was achieved on Eclipse XDB C8 column. Identification was based on two multiple reaction monitoring transitions and the relative ion intensity. Read More

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December 2013

Cocaine intoxication.

Crit Care Clin 2012 Oct 30;28(4):517-26. Epub 2012 Aug 30.

Department of Medicine, Weill Cornell Medical College, New York, NY, USA.

Cocaine, a natural alkaloid derived from the coca plant, is one of the most commonly abused illicit drugs. Cocaine is commonly abused by inhalation, nasal insufflation, and intravenous injection, resulting in many adverse effects that ensue from local anesthetic, vasoconstrictive, sympathomimetic, psychoactive, and prothrombotic mechanisms. Cocaine can affect all body systems and the clinical presentation may primarily result from organ toxicity. Read More

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October 2012

Atropa belladonna intoxication: a case report.

Pan Afr Med J 2012 17;11:72. Epub 2012 Apr 17.

Intensive Care Unit, Mother and Child Hospital, University Hospital Hassan II, Fes, Morrocco.

Atropa belladonna is a poisonous plant also called deadly nightshade. Its roots, leaves and fruits contain alkaloids: atropine, hyocyamine and scopolamine. The risk of poisoning in children is important because of possible confusion with other berries. Read More

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Acute Datura Stramonium poisoning in East of Iran - a case series.

Avicenna J Phytomed 2012 ;2(2):86-9

Department of Toxicology, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, I. R. Iran.

Objectives: Datura Stramonium (DS) is a common weed along roadsides, in cornfields and pastures and in waste areas. It belongs to the family Solanaceae and its toxic components are tropane belladonna alkaloids. It has been used voluntarily by teenagers for its hallucinogenic effect. Read More

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Application of an enantioselective LC-ESI MS/MS procedure to determine R- and S-hyoscyamine following intravenous atropine administration in swine.

Drug Test Anal 2012 Mar-Apr;4(3-4):194-8. Epub 2011 Oct 1.

Bundeswehr Institute of Pharmacology andToxicology Neuherbergstrasse 11, Munich, Germany.

S-hyoscyamine (S-hyo) is a natural plant tropane alkaloid acting as a muscarinic receptor (MR) antagonist. Its racemic mixture (atropine) is clinically used in pre-anaesthesia, ophthalmology and for the antidotal treatment of organophosphorus (OP) poisoning with nerve agents or pesticides even though R-hyo exhibits no effects on MR. Further investigative research is required to optimize treatment of OP poisoning. Read More

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Plant poisons: their occurrence, biochemistry and physiological properties.

Margaret Vickery

Sci Prog 2010 ;93(Pt 2):181-221

Butterfly Conservation Warwickshire, Kenilworth, Warwickshire, UK.

Plants produce poisons as a defence against predators. Many of these substances are biosynthesised from non-protein amino acids by biosynthetic pathways which have been deduced from the results of isotopic tracer analysis. These secondary metabolites have been used by humans over thousands of years, both as drugs and as agents to kill animals and commit homicide. Read More

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