117 results match your criteria Plant Poisoning Alkaloids - Tropane


Neurological syndrome in goats associated with Ipomoea trifida and Ipomoea carnea containing calystegines.

Toxicon 2019 Jan 14;157:8-11. Epub 2018 Nov 14.

Facultad de Veterinaria, Universidad de León, Campus de Vegazana, León, Spain.

A disease characterized by ataxia, tremors and nystagmus had been observed in goats in Nicaragua. The main histologic lesions were loss and neuronal vacuolation of Purkinje cells and Wallerian-like degeneration mainly in the cerebellum, suggesting a glycoprotein storage disease. Ipomoea carnea and Ipomoea trifida found in the paddocks were negative for swainsonine, but contained calystegines at 0. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00410101183101
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http://dx.doi.org/10.1016/j.toxicon.2018.11.291DOI Listing
January 2019
5 Reads

Simultaneous quantification of atropine and scopolamine in infusions of herbal tea and Solanaceae plant material by matrix-assisted laser desorption/ionization time-of-flight (tandem) mass spectrometry.

Rapid Commun Mass Spectrom 2018 Nov;32(22):1911-1921

Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany.

Rationale: Atropine (Atr) and scopolamine (Scp) are toxic secondary plant metabolites of species within the Solanaceae genus that can accidentally or intentionally reach the food store chain by inaccurate harvesting of any plant material, e.g. for herbal tea infusions. Read More

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http://doi.wiley.com/10.1002/rcm.8264
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http://dx.doi.org/10.1002/rcm.8264DOI Listing
November 2018
11 Reads

Worldwide Occurrence and Investigations of Contamination of Herbal Medicines by Tropane Alkaloids.

Authors:
Thomas Y K Chan

Toxins (Basel) 2017 09 15;9(9). Epub 2017 Sep 15.

Division of Clinical Pharmacology and Drug and Poisons Information Bureau, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China.

Tropane alkaloids occur mainly in plants. In the present review, the main objective is to describe the worldwide occurrence and investigations of anticholinergic poisoning due to the contamination of herbal teas and herbs by tropane alkaloids. Tropane alkaloid poisoning can occur after consumption of any medicinal plant if plants or plant parts are present as contaminants. Read More

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http://www.mdpi.com/2072-6651/9/9/284
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http://dx.doi.org/10.3390/toxins9090284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618217PMC
September 2017
20 Reads

Identification of Datura Species Involved in a Food-Poisoning Case Using LC-MS/MS and DNA Barcording.

Shokuhin Eiseigaku Zasshi 2017 ;58(2):86-95

Kawasaki City Institute for Public Health.

A food-poisoning case due to eating the roots of Datura occurred in Kawasaki City, Japan in 2014. The Datura plant was mistakenly collected instead of burdock in a domestic garden. The roots of these plants are quite similar to each other. Read More

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http://dx.doi.org/10.3358/shokueishi.58.86DOI Listing
June 2017
12 Reads

Maternal Ingestion of Ipomoea carnea: Effects on Goat-Kid Bonding and Behavior.

Toxins (Basel) 2016 Mar 16;8(3). Epub 2016 Mar 16.

Research Center of Veterinary Toxicology (CEPTOX), Department of Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo, Pirassununga 13635-900, Brazil.

Ipomoea carnea is a toxic plant found in Brazil and other tropical and subtropical countries and often causes poisoning of livestock. The plant contains the alkaloids swainsonine and calystegines, which inhibit key cellular enzymes and cause systematic cell death. This study evaluated the behavioral effects of prenatal ingestion of this plant on dams and their kids. Read More

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http://dx.doi.org/10.3390/toxins8030074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810219PMC
March 2016
3 Reads

Accidental overdose in the deep shade of night: a warning on the assumed safety of 'natural substances'.

BMJ Case Rep 2015 Nov 5;2015. Epub 2015 Nov 5.

Adult Intensive Care Department, Oxford University Hospitals NHS Trust, Oxford, UK.

There is an increasing use of herbal remedies and medicines, with a commonly held belief that natural substances are safe. We present the case of a 50-year-old woman who was a trained herbalist and had purchased an 'Atropa belladonna (deadly nightshade) preparation'. Attempting to combat her insomnia, late one evening she deliberately ingested a small portion of this, approximately 50 mL. Read More

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http://dx.doi.org/10.1136/bcr-2015-209333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654174PMC
November 2015
16 Reads

Black henbane and its toxicity - a descriptive review.

Avicenna J Phytomed 2014 Sep;4(5):297-311

Medical Toxicology Research Centre, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, I. R. Iran.

Black henbane (BH) or Hyoscyamus niger, has been used as a medicine since last centuries and has been described in all traditional medicines. It applies as a herbal medicine, but may induce intoxication accidentally or intentionally. All part of BH including leaves, seeds and roots contain some alkaloids such as Hyoscyamine, Atropine, Tropane and Scopolamine. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224707PMC
September 2014
8 Reads

Intoxication by angel's trumpet: case report and literature review.

BMC Res Notes 2014 Aug 20;7:553. Epub 2014 Aug 20.

Department of Neurology, CHA Bundang Medical Center, CHA University, 59 Yatap-ro, Bundang-gu, Seongnam-si, Gyeonggi-do 463-712, South Korea.

Background: Brugmansia, commonly referred to as angel's trumpet (AT), has been become popular in Korea as an ornamental shrub. However, it is not generally known by the public that this plant contains tropane alkaloids, and that ingestion of AT can lead to anticholinergic poisoning.

Case Presentation: A 64-year-old Korean female presented with acute mental changes caused by inadvertent ingestion of the petals of AT flowers used as a garnish in a traditional Korean food (bibimbop). Read More

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http://dx.doi.org/10.1186/1756-0500-7-553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148940PMC
August 2014
8 Reads

Toxicological findings in a fatal multidrug intoxication involving mephedrone.

Forensic Sci Int 2014 Oct 6;243:68-73. Epub 2014 May 6.

Centro Regionale Antidoping "A. Bertinaria" - Laboratorio Regionale di Tossicologia, Regione Gonzole 10/1, Orbassano, Turin 10043, Italy; Dipartimento di Chimica, Università degli Studi di Torino, via P. Giuria 7, Turin 10125, Italy.

The distribution of mephedrone in the body fluids and tissues of a subject found dead after the concomitant intake of cocaine and mephedrone is reported. Mephedrone (4-methylmethcathinone) is a designer drug of the phenethylamine family that is able to cause central nervous system stimulation, psychoactivity and hallucinations and that is becoming popular among youth as a recreational drug. Mephedrone has been available in Europe since 2007, and it is sold through the internet and by local shops as bath salt or plant food. Read More

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http://dx.doi.org/10.1016/j.forsciint.2014.04.038DOI Listing
October 2014
4 Reads

[Poisoning by the use of Datura plants].

Authors:
Tatsuo Fukuda

Chudoku Kenkyu 2014 Mar;27(1):10-3

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March 2014
5 Reads

[Acute intoxication in adults - what you should know].

Authors:
Th Zilker

Dtsch Med Wochenschr 2014 Jan 3;139(1-2):31-46; quiz 43-6. Epub 2014 Jan 3.

München.

Ingestion of household products and plants are the leading cause for calls to the poison control centres as far as children are involved. Severe intoxication in children has become infrequent due to childproofed package and blister packs for drugs. Chemical accidents in adults give rise to hospital admission in only 5 %. Read More

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http://dx.doi.org/10.1055/s-0033-1359902DOI Listing
January 2014
20 Reads

Belladonna Alkaloid Intoxication: The 10-Year Experience of a Large Tertiary Care Pediatric Hospital.

Am J Ther 2016 Jan-Feb;23(1):e74-7

1Division of Pediatric Emergency Medicine, Department of Pediatrics, Dana-Dwek Children Hospital, Tel Aviv University, Tel Aviv, Israel; 2Division of Clinical Pharmacology and Toxicology, Ichilov Hospital, Tel Aviv University, Tel Aviv, Israel; and 3Division of Pediatric Emergency Medicine, Department of Pediatrics, and 4Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, University of Toronto, Ontario, Canada.

The belladonna alkaloids can be isolated from a number of plants, which contain hallucinogens that represent a serious danger to infants, children, and adolescents. Roots, leaves, and fruits of the plant contain the alkaloids atropine, hyoscyamine, and scopolamine, which can lead to an anticholinergic toxidrome; however, not all characteristics of the toxidrome are necessarily present in each case of poisoning. A retrospective chart review of all children seen following anticholinergic ingestions, between April 2001 and November 2010, at the Hospital for Sick Children in Toronto. Read More

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/01.mjt.0000433940.91996.16DOI Listing
October 2016
8 Reads

Simultaneous detection of 22 toxic plant alkaloids (aconitum alkaloids, solanaceous tropane alkaloids, sophora alkaloids, strychnos alkaloids and colchicine) in human urine and herbal samples using liquid chromatography-tandem mass spectrometry.

J Chromatogr B Analyt Technol Biomed Life Sci 2013 Dec 22;942-943:63-9. Epub 2013 Oct 22.

Hospital Authority Toxicology Reference Laboratory, Princess Margaret Hospital, Hong Kong.

A liquid chromatography-tandem mass spectrometry method for simultaneous detection of 22 toxic plant alkaloids, including aconitum alkaloids and their hydrolyzed products (aconitine, hypaconitine, mesaconitine, yunaconitine, crassicauline A, benzoylaconine, benzoylmesaconine, benzoylhypaconine, deacetylyunaconitine, deacetylcrassicauline A), solanaceous tropane alkaloids (atropine, anisodamine, scopolamine, anisodine), sophora alkaloids (matrine, sophoridine, oxymatrine, cytisine, N-methylcytisine), strychnos alkaloids (brucine, strychnine) and colchicine, in herbal and urine samples was developed and validated. Following sample preparation by liquid-liquid extraction, chromatographic separation was achieved on Eclipse XDB C8 column. Identification was based on two multiple reaction monitoring transitions and the relative ion intensity. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15700232130055
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http://dx.doi.org/10.1016/j.jchromb.2013.10.020DOI Listing
December 2013
64 Reads

Cocaine intoxication.

Crit Care Clin 2012 Oct 30;28(4):517-26. Epub 2012 Aug 30.

Department of Medicine, Weill Cornell Medical College, New York, NY, USA.

Cocaine, a natural alkaloid derived from the coca plant, is one of the most commonly abused illicit drugs. Cocaine is commonly abused by inhalation, nasal insufflation, and intravenous injection, resulting in many adverse effects that ensue from local anesthetic, vasoconstrictive, sympathomimetic, psychoactive, and prothrombotic mechanisms. Cocaine can affect all body systems and the clinical presentation may primarily result from organ toxicity. Read More

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http://dx.doi.org/10.1016/j.ccc.2012.07.003DOI Listing
October 2012
4 Reads

Atropa belladonna intoxication: a case report.

Pan Afr Med J 2012 17;11:72. Epub 2012 Apr 17.

Intensive Care Unit, Mother and Child Hospital, University Hospital Hassan II, Fes, Morrocco.

Atropa belladonna is a poisonous plant also called deadly nightshade. Its roots, leaves and fruits contain alkaloids: atropine, hyocyamine and scopolamine. The risk of poisoning in children is important because of possible confusion with other berries. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361210PMC
August 2012
18 Reads

Acute Datura Stramonium poisoning in East of Iran - a case series.

Avicenna J Phytomed 2012 ;2(2):86-9

Department of Toxicology, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, I. R. Iran.

Objectives: Datura Stramonium (DS) is a common weed along roadsides, in cornfields and pastures and in waste areas. It belongs to the family Solanaceae and its toxic components are tropane belladonna alkaloids. It has been used voluntarily by teenagers for its hallucinogenic effect. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075664PMC
July 2014
5 Reads

Application of an enantioselective LC-ESI MS/MS procedure to determine R- and S-hyoscyamine following intravenous atropine administration in swine.

Drug Test Anal 2012 Mar-Apr;4(3-4):194-8. Epub 2011 Oct 1.

Bundeswehr Institute of Pharmacology andToxicology Neuherbergstrasse 11, Munich, Germany.

S-hyoscyamine (S-hyo) is a natural plant tropane alkaloid acting as a muscarinic receptor (MR) antagonist. Its racemic mixture (atropine) is clinically used in pre-anaesthesia, ophthalmology and for the antidotal treatment of organophosphorus (OP) poisoning with nerve agents or pesticides even though R-hyo exhibits no effects on MR. Further investigative research is required to optimize treatment of OP poisoning. Read More

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http://doi.wiley.com/10.1002/dta.338
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http://dx.doi.org/10.1002/dta.338DOI Listing
July 2012
6 Reads

Plant poisons: their occurrence, biochemistry and physiological properties.

Authors:
Margaret Vickery

Sci Prog 2010 ;93(Pt 2):181-221

Butterfly Conservation Warwickshire, Kenilworth, Warwickshire, UK.

Plants produce poisons as a defence against predators. Many of these substances are biosynthesised from non-protein amino acids by biosynthetic pathways which have been deduced from the results of isotopic tracer analysis. These secondary metabolites have been used by humans over thousands of years, both as drugs and as agents to kill animals and commit homicide. Read More

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August 2010
7 Reads

An unusual case of anisocoria by vegetal intoxication: a case report.

Ital J Pediatr 2010 Jul 20;36:50. Epub 2010 Jul 20.

U,O,C Pediatria Generale Dipartimento di Medicina Pediatrica, Ospedale Pediatrico Bambino Gesù, P,zza Sant'Onofrio 4, 00165 Roma, Italy.

A 12 year old boy presented with an acute onset of anisocoria and blurred vision. Ocular motility was normal but his right pupil was dilated, round but sluggishly reactive to light. There was no history of trauma, eye drops' instillation, nebulised drugs or local ointments. Read More

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http://dx.doi.org/10.1186/1824-7288-36-50DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2914661PMC
July 2010
8 Reads

Aspects of Datura poisoning and treatment.

Clin Toxicol (Phila) 2010 Feb;48(2):104-10

Department of Pharmacy and Therapeutics, Pittsburgh Poison and Drug Information Center, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, USA.

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February 2010
2 Reads

Mass intoxication with Datura innoxia--case series and confirmation by analytical toxicology.

Clin Toxicol (Phila) 2010 Feb;48(2):143-5

Department of Forensic Medicine and Toxicology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

Background: Anticholinergic plants contain a variety of alkaloids that are toxic if ingested. Datura innoxia belongs to the family of Solanaceae and contains two main toxic alkaloids, atropine and scopolamine.

Case Series: In this study we report the case series of seven individuals who were admitted to two different hospitals of Athens with an anticholinergic syndrome. Read More

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http://dx.doi.org/10.3109/15563650903524134DOI Listing
February 2010
5 Reads

Carbamate poisoning in a dairy goat herd: clinicopathological findings and therapeutic approach.

N Z Vet J 2009 Dec;57(6):392-4

Clinic of Farm Animals, School of Veterinary Medicine, Aristotle University of Thessaloniki, 11 St Voutyra Street, 546 27 Thessaloniki, Greece.

Case History: Approximately 1 hour after the consumption of carnations from a nearby glasshouse 55 animals from a dairy goat herd exhibited signs of possible poisoning.

Clinical Findings: Upon clinical examination affected animals exhibited signs of salivation, tympany, tachypnoea, polydipsia, urination, diarrhoea, bradycardia, miosis, tremor and convulsions. As poisoning from an acetylcholinesterase-inhibiting insecticide was suspected, treatment with atropine sulphate was initiated at a dose of 0. Read More

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http://www.tandfonline.com/doi/abs/10.1080/00480169.2009.647
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http://dx.doi.org/10.1080/00480169.2009.64735DOI Listing
December 2009
21 Reads

Zigadenus poisoning treated with atropine and dopamine.

J Med Toxicol 2009 Dec;5(4):214-7

Oregon Health and Science University, Oregon Poison Center, Portland, OR 97239, USA.

Introduction: Zigadenus (commonly known as "death camas" or "mountain camas") is a common plant in the lily family found throughout the United States. Its onion-like roots can be mistaken for an edible plant. Ingestion may cause hemodynamic instability which has successfully been treated with atropine. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3550413PMC
December 2009
4 Reads

Atrioventricular block induced by mad-honey intoxication: confirmation of diagnosis by pollen analysis.

Tex Heart Inst J 2009 ;36(4):342-4

Department of Cardiology, Ankara Turkiye Yuksek Ihtisas Hospital, Ankara, Turkey.

An unusual type of food poisoning, mad-honey intoxication, can be observed in the Black Sea region of Turkey and various other parts of the world. It can occur after ingestion of grayanotoxin-contaminated honey produced from the nectar of Rhododendron ponticum and other plant species, chiefly of the Ericaceae and Sapindaceae families. Mad-honey intoxication can result in severe cardiac complications, such as complete atrioventricular block. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720281PMC
October 2009
41 Reads

Plasma level of atropine after accidental ingestion of Atropa belladonna.

Clin Toxicol (Phila) 2009 Jul;47(6):602-4

Central Institute of the Bundeswehr Medical Service, München, Germany. reinhardbogan@ bundeswehr.org

Background: Ingestion of toxic plant constituents still poses a challenge in clinical management. The amount of berries ingested is often unclear and in the case of Atropa belladonna may affect clinical outcome. Plasma levels of atropine may thus be useful in confirming the cause of intoxication. Read More

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http://dx.doi.org/10.1080/15563650903058906DOI Listing
July 2009
7 Reads

Solanum erianthum intoxication mimicking an acute cerebrovascular disease.

Am J Emerg Med 2009 Feb;27(2):249.e1-2

Department of Emergency Medicine, Mackay Memorial Hospital, Taipei 10449, Taiwan.

We describe a case of Solanum erianthum poisoning that happened to a 75-year-old man. He ate the S erianthum that he gathered from the countryside, believing that it would be helpful in improving the numbness of his distal limbs. S erianthum is a solanaceous plant that contains a variable concentration of solanum alkaloids, causing gastrointestinal irritation, and tropane alkaloids that have anticholinergic properties producing typical and sometimes severe atropinelike symptoms. Read More

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http://dx.doi.org/10.1016/j.ajem.2008.05.026DOI Listing
February 2009
20 Reads

Acute anticholinergic syndrome from Atropa belladonna mistaken for blueberries.

Eur J Ophthalmol 2009 Jan-Feb;19(1):170-2

Ophthalmology Clinic, Department of Clinical Neurosciences, Geneva University Hospital, Geneva, Switzerland.

Purpose: To report the first case in the ophthalmic literature of acute anticholinergic syndrome after ingestion of Atropa belladonna mistaken for blueberries.

Methods: A 36-year-old woman presented to our ophthalmic emergency department with complaints of blurry vision, lightning flashes, disorientation, loss of balance, agitation, and anxiety for 24 hours. Ophthalmic examination revealed bilateral pupillary dilatation and paresis of accommodation. Read More

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May 2009
7 Reads

Fatal injury in eastern Sri Lanka, with special reference to cardenolide self-poisoning with Cerbera manghas fruits.

Clin Toxicol (Phila) 2008 Sep;46(8):745-8

Scottish Poisons Information Bureau, Royal Infirmary of Edinburgh, and Clinical Pharmacology Unit, University of Edinburgh, United Kingdom.

Objective: Self-poisoning with plant seeds or fruits is a common method of self-harm in South Asia. While most deaths follow ingestion of Thevetia peruviana (yellow oleander) seeds, other plants are locally common. During review of fatal injuries seen in a teaching hospital in eastern Sri Lanka, we noted cases of fatal self-poisoning with Cerbera manghas (sea mango, pink eyed cerbera, odollam tree) fruits. Read More

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http://dx.doi.org/10.1080/15563650701668617DOI Listing
September 2008
8 Reads

[Determination of hyoscyamine and scopolamine in serum and urine of humans by liquid chromatography with tandem mass spectrometry].

Shokuhin Eiseigaku Zasshi 2008 Aug;49(4):266-71

Fukuoka City Institute for Hygiene and the Environment. Funuoka, Japan.

A simple method was developed for the analysis of hyoscyamine and scopolamine in human serum and urine using liquid chromatography with tandem mass spectrometry (LC/MS/MS). Hyoscyamine and scopolamine in serum and urine were cleaned up with an Oasis HLB cartridge and a PSA cartridge. The LC separation was carried out on an ODS column, using linear gradient elution with 5 mmol/L IPCC-MS3-methanol as the mobile phase. Read More

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August 2008
6 Reads

The comparative pathology of the glycosidase inhibitors swainsonine, castanospermine, and calystegines A3, B2, and C1 in mice.

Toxicol Pathol 2008 Jul 22;36(5):651-9. Epub 2008 May 22.

USDA-ARS, Poisonous Plant Research Laboratory, Logan, Utah 84321, USA.

To study various polyhydroxy-alkaloid glycosidase inhibitors, 16 groups of 3 mice were dosed using osmotic minipumps with swainsonine (0, 0.1, 1, and 10 mg/kg/day), castanospermine, and calystegines A(3), B(2), and C(1) (1, 10, and 100 mg/kg/day). After 28 days, the mice were euthanized, necropsied, and examined using light and electron microscopy. Read More

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http://tpx.sagepub.com/content/early/2008/05/22/019262330831
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http://tpx.sagepub.com/cgi/doi/10.1177/0192623308317420
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http://dx.doi.org/10.1177/0192623308317420DOI Listing
July 2008
14 Reads

Unilateral mydriasis due to Angel's trumpet.

Clin Toxicol (Phila) 2008 Apr;46(4):329-31

Department of Pediatrics, University of Padova, Padova, Italy.

Introduction: There are many causes of bilateral and unilateral mydriasis. Common garden plants, such as Brugmansia (Angel's trumpet), contain tropane alkaloids.

Case Report: An 11-year-old girl was brought to the Emergency Department because of discomfort and difficulty with near vision in the left eye, accompanied by unilateral mydriasis (pupil approximately 8 mm, unresponsive to both papillary light reflex and accommodation reflex). Read More

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http://dx.doi.org/10.1080/15563650701378720DOI Listing
April 2008
4 Reads

It could have happened to Van Gogh: a case of fatal purple foxglove poisoning and review of the literature.

Eur J Emerg Med 2007 Dec;14(6):356-9

Emergency Department, Northern General Hospital, Sheffield S5 7AU, UK.

Although death owing to the toxic effects of the therapeutic Digitalis lanata extract, digoxin has been reported, there are no reported cases of fatal Digitalis purpurea (digitoxin) plant intoxication in humans in the literature. We describe a case of ingestion of Digitalis purpurea in a 64-year-old man, which was fatal despite administration of Digibind. A review of the literature and aspects of management of plant digitalis poisoning are discussed. Read More

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http://dx.doi.org/10.1097/MEJ.0b013e3280bef8dcDOI Listing
December 2007
14 Reads

Solanaceae IV: Atropa belladonna, deadly nightshade.

Authors:
M R Lee

J R Coll Physicians Edinb 2007 Mar;37(1):77-84

Clinical Pharmacology and Therapeutics, University of Edinburgh, Edinburgh, Scotland.

The Deadly Nightshade, Atropa belladonna, is a plant surrounded by myth, fear and awe. In antiquity, the Greeks and the Romans knew that it contained a deadly poison. In medieval times, it was widely used by witches, sorcerors and professional poisoners. Read More

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March 2007
9 Reads

Solanaceae III: henbane, hags and Hawley Harvey Crippen.

Authors:
M R Lee

J R Coll Physicians Edinb 2006 Dec;36(4):366-73

Clinical Pharmacology and Therapeutics, University of Edinburgh, Edinburgh, Scotland.

Hyoscyamus, the henbane, is one of the drugs of the ancients. Initially used both as a poison and narcotic, it was widely adopted by witches, wizards and soothsayers as a component of their hallucinatory and flying ointments. It was also used by notorious poisoners such as Madame Voisin in France. Read More

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December 2006
2 Reads

The pharmacological properties of anisodamine.

J Appl Toxicol 2007 Mar-Apr;27(2):116-21

Physician Assistant Branch, Department of Medical Sciences, AMEDD Center and School, Ft. Sam Houston, Texas 78234, USA.

Anisodamine is a naturally occurring atropine derivative that has been isolated, synthesized and characterized by scientists in the People's Republic of China. Like atropine and scopolamine, anisodamine is a non-specific cholinergic antagonist exhibiting the usual spectrum of pharmacological effects of this drug class. It appears to be less potent and less toxic than atropine and displays less CNS toxicity than scopolamine. Read More

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http://dx.doi.org/10.1002/jat.1154DOI Listing
April 2007
8 Reads

Confirmed Datura poisoning in a horse most probably due to D. ferox in contaminated tef hay.

J S Afr Vet Assoc 2006 Jun;77(2):86-9

Department of Animal Sciences, Faculty of Agricultural Sciences, Tshwane University of Technology, Private Bag X680, Pretoria 0001, South Africa.

Two out of a group of 23 mares exposed to tef hay contaminated with Datura ferox (and possibly D. stramonium) developed colic. The 1st animal was unresponsive to conservative treatment, underwent surgery for severe intestinal atony and had to be euthanased. Read More

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June 2006
4 Reads

Testing for atropine and scopolamine in hair by LC-MS-MS after Datura inoxia abuse.

J Anal Toxicol 2006 Sep;30(7):454-7

Laboratoire ChemTox, 3 rue Gruninger, 67400 Illkirch, France.

Datura inoxia belongs to the family of Solanaceae. This is a very common plant in New Caledonia that contains two main toxic alkaloids, l-atropine and l-scopolamine. In this study, we report the case of a 20-year-old male admitted to an Emergency Unit after consumption of 6 dried flowers in hot water for hallucinations, mydriasis, and agitation associated with tachycardia and increase of systolic blood pressure to 180. Read More

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http://jat.oxfordjournals.org/content/30/7/454.full.pdf
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September 2006
14 Reads

The early toxicology of physostigmine: a tale of beans, great men and egos.

Authors:
Alex Proudfoot

Toxicol Rev 2006 ;25(2):99-138

National Poisons Information Service (Birmingham Centre), City Hospital, Birmingham, UK.

Mid-19th century European visitors to Old Calabar, an eastern province of Nigeria, could not avoid becoming aware of native belief in the power of the seeds of a local plant to determine whether individuals were innocent or guilty of some serious misdemeanour. The seeds were those of a previously unknown legume and soon referred to as the ordeal bean of Old Calabar. Their administration was known locally as 'chop nut'. Read More

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http://link.springer.com/content/pdf/10.2165/00139709-200625
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February 2007
7 Reads

Case report: acute unintentional carbachol intoxication.

Crit Care 2006 1;10(3):R84. Epub 2006 Jun 1.

Department of Pharmacology, University of Frankfurt, and Head, Center for Drug Information and Pharmacy Practice, ABDA-Federal Union of German Associations of Pharmacists, Jaegerstrasse 49/50, 10117 Berlin, Germany.

Introduction: Intoxications with carbachol, a muscarinic cholinergic receptor agonist are rare. We report an interesting case investigating a (near) fatal poisoning.

Methods: The son of an 84-year-old male discovered a newspaper report stating clinical success with plant extracts in Alzheimer's disease. Read More

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http://dx.doi.org/10.1186/cc4937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1550933PMC
October 2006
11 Reads

Anticholinergic syndrome due to 'Devil's herb': when risks come from the ancient time.

Int J Clin Pract 2006 Apr;60(4):492-4

Division of Emergency Medicine,Cannizzaro Hospital, Catania, Italy.

We describe a case of Mandragora autumnalis poisoning which occurred in a 72-year-old female patient who had eaten the venenous M. Autumnalis, picked near her home, mistaking it for the edible Borago Officinalis. M. Read More

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http://dx.doi.org/10.1111/j.1368-5031.2006.00864.xDOI Listing
April 2006
2 Reads

Acute Erycibe henryi Prain ("Ting Kung Teng") poisoning.

Clin Toxicol (Phila) 2006 ;44(1):71-5

Department of Emergency Medicine, Taipei Veterans General Hospital and School of Medicine, National Yang-Ming University, Taiwan.

Erycibe henryi Prain ("Ting Kung Teng"), a species of Convolvulaceae, has been used in Chinese medicine to relieve pain involving the musculoskeletal system, such as arthritis, sciatica, and traumatic tissue swelling. E. henryi can be mistaken for another herbal plant, Tripterygium wilfordii Hook F, used to treat gouty arthritis. Read More

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March 2006
8 Reads

Intoxication by Ipomoea sericophylla and Ipomoea riedelii in goats in the state of Paraíba, Northeastern Brazil.

Toxicon 2006 Mar 20;47(4):371-9. Epub 2006 Feb 20.

Programa de Pós-Graduação em Ciência Veterinária, Universidade Rural de Pernambuco, CEP 52171-900, Recife PE, Brazil.

A disease of the nervous system was observed in goats from two farms of the semiarid of the state of Paraíba, northeastern Brazil. Ipomoea sericophylla was found in one farm and I. riedelii in the other. Read More

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http://dx.doi.org/10.1016/j.toxicon.2005.11.010DOI Listing
March 2006
4 Reads

Case report of a smuggler's dinner: carrots and asparagus, or bolitas?

Med Sci Monit 2005 Dec 24;11(12):CS79-81. Epub 2005 Nov 24.

Department of Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

Background: Body packing is a distinct method of drug smuggling. Surgeons and intensive care specialists will be confronted with body packers when packets do not pass spontaneously and rupture, causing drug toxicity.

Case Report: We report of a 32-year-old Liberian male who presented with abdominal complaints and anxiety after having ingested 50 cocaine-containing packets of which 49 had passed the natural route in the previous days. Read More

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December 2005
4 Reads

Hallucinogenic plant poisoning in children.

Saudi Med J 2005 Jan;26(1):118-21

Department of Pediatrics, Armed Forces Hospital Southern Region, PO Box 101, Khamis Mushayt, Kingdom of Saudi Arabia.

Datura is a hallucinogenic plant found in urban or rural areas in the Kingdom of Saudi Arabia KSA. It grows wildly in many parts of the country. Its taste and shape makes it unattractive to both man and animals, though deliberate use by young adults for its hallucinogenic effects have been widely reported for the past 30 years. Read More

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January 2005
5 Reads

Association of diamine oxidase and S-adenosylhomocysteine hydrolase in Nicotiana tabacum extracts.

Plant Mol Biol 2004 Sep;56(2):299-308

Plant Pathology, Physiology, and Weed Science Deptartment, Fralin Biotechnology Center, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061-0346, USA.

The oxidative deamination of methylated putrescine by a diamine oxidase activity (DAO) is an important step in the biosynthesis of nicotine in tobacco and tropane alkaloids in several Solanaceous plants. A polyclonal rabbit antiserum was previously developed to a purported purified DAO enzyme from Nicotiana tabacum. The antiserum bound to a single 53 kDa protein and immunoprecipitated 80% of DAO activity from tobacco root extracts. Read More

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http://link.springer.com/content/pdf/10.1007/s11103-004-3352
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http://link.springer.com/10.1007/s11103-004-3352-7
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http://dx.doi.org/10.1007/s11103-004-3352-7DOI Listing
September 2004
3 Reads

Antimuscarinic intoxication resulting from the ingestion of moonflower seeds.

Ann Pharmacother 2005 Jan 30;39(1):173-6. Epub 2004 Nov 30.

College of Pharmacy, University of Iowa, Iowa City, IA, USA.

Objective: To report a case in which ingestion of moonflower seeds resulted in antimuscarinic intoxication.

Case Summary: An 18-year-old man was found at a local convenience store hallucinating and incoherent. Upon presentation to the emergency department, his signs and symptoms included tachycardia, confusion, dilated pupils, and dry, flushed, hot skin. Read More

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http://dx.doi.org/10.1345/aph.1D536DOI Listing
January 2005
3 Reads

Daffodil toxicosis in an adult cat.

Can Vet J 2004 Mar;45(3):248-50

Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1.

A domestic longhair cat with a 3-day history of lethargy and vomiting after ingesting dried daffodil stems (Narcissus spp.) was severely hypothermic (33.0 degrees C), with bradycardia (78 beats/ min) and hypotension. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC548613PMC
March 2004
4 Reads

Poisonings and overdoses in the intensive care unit: general and specific management issues.

Crit Care Med 2003 Dec;31(12):2794-801

Department of Medicine, Baylor College of Medicine, Houston, TX, USA.

Objective: To provide current information on general and specific interventions for overdoses likely to require intensive care.

Design: Review of literature relevant to selected interventions for general management of overdoses and specific poisons.

Results: The benefit of interventions to decrease absorption or enhance elimination of toxins is limited to a relatively small number of specific agents. Read More

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http://dx.doi.org/10.1097/01.CCM.0000100123.50896.F0DOI Listing
December 2003
5 Reads