122 results match your criteria Plant Poisoning Alkaloids - Tropane


Common anticholinergic solanaceaous plants of temperate Europe - A review of intoxications from the literature (1966-2018).

Toxicon 2020 Apr 13;177:52-88. Epub 2020 Feb 13.

Faculty of Pharmacy, University of Ljubljana, Tržaška Cesta 32, 1000, Ljubljana, Slovenia.

Datura stramonium, Atropa belladonna, Hyoscyamus niger, and Scopolia carniolica are all temperate plants from the family Solanaceae, which as a result of their anticholinergic tropane alkaloids, hyoscyamine/atropine and scopolamine, have caused many cases of poisoning around the world. Despite the danger these nightshade plants represent, the literature often presents incomplete cases lacking in details and filled with ambiguity, and reviews on the topic tend to be limited in scope. Many also point to a gap in knowledge of these plants among physicians. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.toxicon.2020.02.005DOI Listing

Remember Atropine for "Killer B's".

J Emerg Med 2019 11;57(5):731

Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, Groningen, Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jemermed.2018.09.061DOI Listing
November 2019

Clinical and pathological comparison of Astragalus lentiginosus and Ipomoea carnea poisoning in goats.

Toxicon 2019 Dec 19;171:20-28. Epub 2019 Sep 19.

USDA-ARS Poisonous Plant Research Laboratory, 1150 E. 1400 N, Logan, UT, USA, 84341.

The indolizidine alkaloid swainsonine, found in some Astragalus and Oxytropis (i.e., locoweed) species, is a potent cellular glycosidase inhibitor that often poisons livestock. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.toxicon.2019.09.016DOI Listing
December 2019
1 Read

Urine tropenol ester levels in workers handling tiotropium bromide synthesis: implications for exposure prevention and biomonitoring.

Arh Hig Rada Toksikol 2019 Jun;70(2):118-122

Institute of Occupational, Social and Environmental Medicine, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

Tropenol ester is a highly toxic anticholinergic substance and an intermediate used in industrial production of the bronchodilator tiotropium bromide. The aim of this study was to systematically test workers involved in its production for tropenol ester in urine to identify any exposure pathways and define additional preventive measures. Twelve workers performing tasks involving potential exposure to tropenol ester were repeatedly monitored at the end of each production cycle. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2478/aiht-2019-70-3206DOI Listing
June 2019
1 Read

Alkaloid chemodiversity in Mandragora spp. is associated with loss-of-functionality of MoH6H, a hyoscyamine 6β-hydroxylase gene.

Plant Sci 2019 Jun 20;283:301-310. Epub 2019 Mar 20.

Department of Vegetable Crops, Newe Ya'ar Research Center, Agricultural Research Organization, P.O. Box 1021, Ramat Yishay 30095, Israel. Electronic address:

Mandrakes (Mandragora spp., Solanaceae) are known to contain tropane alkaloids and have been used since antiquity in traditional medicine. Tropane alkaloids such as scopolamine and hyoscyamine are used in modern medicine to treat pain, motion sickness, as eye pupil dilators and antidotes against organo-phosphate poisoning. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.plantsci.2019.03.013DOI Listing
June 2019
19 Reads

Neurological syndrome in goats associated with Ipomoea trifida and Ipomoea carnea containing calystegines.

Toxicon 2019 Jan 14;157:8-11. Epub 2018 Nov 14.

Facultad de Veterinaria, Universidad de León, Campus de Vegazana, León, Spain.

A disease characterized by ataxia, tremors and nystagmus had been observed in goats in Nicaragua. The main histologic lesions were loss and neuronal vacuolation of Purkinje cells and Wallerian-like degeneration mainly in the cerebellum, suggesting a glycoprotein storage disease. Ipomoea carnea and Ipomoea trifida found in the paddocks were negative for swainsonine, but contained calystegines at 0. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00410101183101
Publisher Site
http://dx.doi.org/10.1016/j.toxicon.2018.11.291DOI Listing
January 2019
36 Reads

Simultaneous quantification of atropine and scopolamine in infusions of herbal tea and Solanaceae plant material by matrix-assisted laser desorption/ionization time-of-flight (tandem) mass spectrometry.

Rapid Commun Mass Spectrom 2018 Nov;32(22):1911-1921

Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany.

Rationale: Atropine (Atr) and scopolamine (Scp) are toxic secondary plant metabolites of species within the Solanaceae genus that can accidentally or intentionally reach the food store chain by inaccurate harvesting of any plant material, e.g. for herbal tea infusions. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/rcm.8264
Publisher Site
http://dx.doi.org/10.1002/rcm.8264DOI Listing
November 2018
45 Reads

Worldwide Occurrence and Investigations of Contamination of Herbal Medicines by Tropane Alkaloids.

Authors:
Thomas Y K Chan

Toxins (Basel) 2017 09 15;9(9). Epub 2017 Sep 15.

Division of Clinical Pharmacology and Drug and Poisons Information Bureau, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China.

Tropane alkaloids occur mainly in plants. In the present review, the main objective is to describe the worldwide occurrence and investigations of anticholinergic poisoning due to the contamination of herbal teas and herbs by tropane alkaloids. Tropane alkaloid poisoning can occur after consumption of any medicinal plant if plants or plant parts are present as contaminants. Read More

View Article

Download full-text PDF

Source
http://www.mdpi.com/2072-6651/9/9/284
Publisher Site
http://dx.doi.org/10.3390/toxins9090284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618217PMC
September 2017
55 Reads

Identification of Datura Species Involved in a Food-Poisoning Case Using LC-MS/MS and DNA Barcording.

Shokuhin Eiseigaku Zasshi 2017 ;58(2):86-95

Kawasaki City Institute for Public Health.

A food-poisoning case due to eating the roots of Datura occurred in Kawasaki City, Japan in 2014. The Datura plant was mistakenly collected instead of burdock in a domestic garden. The roots of these plants are quite similar to each other. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3358/shokueishi.58.86DOI Listing
June 2017
21 Reads

Maternal Ingestion of Ipomoea carnea: Effects on Goat-Kid Bonding and Behavior.

Toxins (Basel) 2016 Mar 16;8(3). Epub 2016 Mar 16.

Research Center of Veterinary Toxicology (CEPTOX), Department of Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo, Pirassununga 13635-900, Brazil.

Ipomoea carnea is a toxic plant found in Brazil and other tropical and subtropical countries and often causes poisoning of livestock. The plant contains the alkaloids swainsonine and calystegines, which inhibit key cellular enzymes and cause systematic cell death. This study evaluated the behavioral effects of prenatal ingestion of this plant on dams and their kids. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/toxins8030074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810219PMC
March 2016
11 Reads

Accidental overdose in the deep shade of night: a warning on the assumed safety of 'natural substances'.

BMJ Case Rep 2015 Nov 5;2015. Epub 2015 Nov 5.

Adult Intensive Care Department, Oxford University Hospitals NHS Trust, Oxford, UK.

There is an increasing use of herbal remedies and medicines, with a commonly held belief that natural substances are safe. We present the case of a 50-year-old woman who was a trained herbalist and had purchased an 'Atropa belladonna (deadly nightshade) preparation'. Attempting to combat her insomnia, late one evening she deliberately ingested a small portion of this, approximately 50 mL. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2015-209333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654174PMC
November 2015
36 Reads

Black henbane and its toxicity - a descriptive review.

Avicenna J Phytomed 2014 Sep;4(5):297-311

Medical Toxicology Research Centre, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, I. R. Iran.

Black henbane (BH) or Hyoscyamus niger, has been used as a medicine since last centuries and has been described in all traditional medicines. It applies as a herbal medicine, but may induce intoxication accidentally or intentionally. All part of BH including leaves, seeds and roots contain some alkaloids such as Hyoscyamine, Atropine, Tropane and Scopolamine. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224707PMC
September 2014
20 Reads

Intoxication by angel's trumpet: case report and literature review.

BMC Res Notes 2014 Aug 20;7:553. Epub 2014 Aug 20.

Department of Neurology, CHA Bundang Medical Center, CHA University, 59 Yatap-ro, Bundang-gu, Seongnam-si, Gyeonggi-do 463-712, South Korea.

Background: Brugmansia, commonly referred to as angel's trumpet (AT), has been become popular in Korea as an ornamental shrub. However, it is not generally known by the public that this plant contains tropane alkaloids, and that ingestion of AT can lead to anticholinergic poisoning.

Case Presentation: A 64-year-old Korean female presented with acute mental changes caused by inadvertent ingestion of the petals of AT flowers used as a garnish in a traditional Korean food (bibimbop). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1756-0500-7-553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148940PMC
August 2014
24 Reads

Toxicological findings in a fatal multidrug intoxication involving mephedrone.

Forensic Sci Int 2014 Oct 6;243:68-73. Epub 2014 May 6.

Centro Regionale Antidoping "A. Bertinaria" - Laboratorio Regionale di Tossicologia, Regione Gonzole 10/1, Orbassano, Turin 10043, Italy; Dipartimento di Chimica, Università degli Studi di Torino, via P. Giuria 7, Turin 10125, Italy.

The distribution of mephedrone in the body fluids and tissues of a subject found dead after the concomitant intake of cocaine and mephedrone is reported. Mephedrone (4-methylmethcathinone) is a designer drug of the phenethylamine family that is able to cause central nervous system stimulation, psychoactivity and hallucinations and that is becoming popular among youth as a recreational drug. Mephedrone has been available in Europe since 2007, and it is sold through the internet and by local shops as bath salt or plant food. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.forsciint.2014.04.038DOI Listing
October 2014
27 Reads

[Poisoning by the use of Datura plants].

Authors:
Tatsuo Fukuda

Chudoku Kenkyu 2014 Mar;27(1):10-3

View Article

Download full-text PDF

Source
March 2014
11 Reads

[Acute intoxication in adults - what you should know].

Authors:
Th Zilker

Dtsch Med Wochenschr 2014 Jan 3;139(1-2):31-46; quiz 43-6. Epub 2014 Jan 3.

München.

Ingestion of household products and plants are the leading cause for calls to the poison control centres as far as children are involved. Severe intoxication in children has become infrequent due to childproofed package and blister packs for drugs. Chemical accidents in adults give rise to hospital admission in only 5 %. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0033-1359902DOI Listing
January 2014
31 Reads

Belladonna Alkaloid Intoxication: The 10-Year Experience of a Large Tertiary Care Pediatric Hospital.

Am J Ther 2016 Jan-Feb;23(1):e74-7

1Division of Pediatric Emergency Medicine, Department of Pediatrics, Dana-Dwek Children Hospital, Tel Aviv University, Tel Aviv, Israel; 2Division of Clinical Pharmacology and Toxicology, Ichilov Hospital, Tel Aviv University, Tel Aviv, Israel; and 3Division of Pediatric Emergency Medicine, Department of Pediatrics, and 4Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, University of Toronto, Ontario, Canada.

The belladonna alkaloids can be isolated from a number of plants, which contain hallucinogens that represent a serious danger to infants, children, and adolescents. Roots, leaves, and fruits of the plant contain the alkaloids atropine, hyoscyamine, and scopolamine, which can lead to an anticholinergic toxidrome; however, not all characteristics of the toxidrome are necessarily present in each case of poisoning. A retrospective chart review of all children seen following anticholinergic ingestions, between April 2001 and November 2010, at the Hospital for Sick Children in Toronto. Read More

View Article

Download full-text PDF

Source
http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
Publisher Site
http://dx.doi.org/10.1097/01.mjt.0000433940.91996.16DOI Listing
October 2016
19 Reads

Simultaneous detection of 22 toxic plant alkaloids (aconitum alkaloids, solanaceous tropane alkaloids, sophora alkaloids, strychnos alkaloids and colchicine) in human urine and herbal samples using liquid chromatography-tandem mass spectrometry.

J Chromatogr B Analyt Technol Biomed Life Sci 2013 Dec 22;942-943:63-9. Epub 2013 Oct 22.

Hospital Authority Toxicology Reference Laboratory, Princess Margaret Hospital, Hong Kong.

A liquid chromatography-tandem mass spectrometry method for simultaneous detection of 22 toxic plant alkaloids, including aconitum alkaloids and their hydrolyzed products (aconitine, hypaconitine, mesaconitine, yunaconitine, crassicauline A, benzoylaconine, benzoylmesaconine, benzoylhypaconine, deacetylyunaconitine, deacetylcrassicauline A), solanaceous tropane alkaloids (atropine, anisodamine, scopolamine, anisodine), sophora alkaloids (matrine, sophoridine, oxymatrine, cytisine, N-methylcytisine), strychnos alkaloids (brucine, strychnine) and colchicine, in herbal and urine samples was developed and validated. Following sample preparation by liquid-liquid extraction, chromatographic separation was achieved on Eclipse XDB C8 column. Identification was based on two multiple reaction monitoring transitions and the relative ion intensity. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15700232130055
Publisher Site
http://dx.doi.org/10.1016/j.jchromb.2013.10.020DOI Listing
December 2013
77 Reads

Cocaine intoxication.

Crit Care Clin 2012 Oct 30;28(4):517-26. Epub 2012 Aug 30.

Department of Medicine, Weill Cornell Medical College, New York, NY, USA.

Cocaine, a natural alkaloid derived from the coca plant, is one of the most commonly abused illicit drugs. Cocaine is commonly abused by inhalation, nasal insufflation, and intravenous injection, resulting in many adverse effects that ensue from local anesthetic, vasoconstrictive, sympathomimetic, psychoactive, and prothrombotic mechanisms. Cocaine can affect all body systems and the clinical presentation may primarily result from organ toxicity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccc.2012.07.003DOI Listing
October 2012
23 Reads

Atropa belladonna intoxication: a case report.

Pan Afr Med J 2012 17;11:72. Epub 2012 Apr 17.

Intensive Care Unit, Mother and Child Hospital, University Hospital Hassan II, Fes, Morrocco.

Atropa belladonna is a poisonous plant also called deadly nightshade. Its roots, leaves and fruits contain alkaloids: atropine, hyocyamine and scopolamine. The risk of poisoning in children is important because of possible confusion with other berries. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361210PMC
August 2012
25 Reads

Acute Datura Stramonium poisoning in East of Iran - a case series.

Avicenna J Phytomed 2012 ;2(2):86-9

Department of Toxicology, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, I. R. Iran.

Objectives: Datura Stramonium (DS) is a common weed along roadsides, in cornfields and pastures and in waste areas. It belongs to the family Solanaceae and its toxic components are tropane belladonna alkaloids. It has been used voluntarily by teenagers for its hallucinogenic effect. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075664PMC
July 2014
25 Reads

Application of an enantioselective LC-ESI MS/MS procedure to determine R- and S-hyoscyamine following intravenous atropine administration in swine.

Drug Test Anal 2012 Mar-Apr;4(3-4):194-8. Epub 2011 Oct 1.

Bundeswehr Institute of Pharmacology andToxicology Neuherbergstrasse 11, Munich, Germany.

S-hyoscyamine (S-hyo) is a natural plant tropane alkaloid acting as a muscarinic receptor (MR) antagonist. Its racemic mixture (atropine) is clinically used in pre-anaesthesia, ophthalmology and for the antidotal treatment of organophosphorus (OP) poisoning with nerve agents or pesticides even though R-hyo exhibits no effects on MR. Further investigative research is required to optimize treatment of OP poisoning. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/dta.338
Publisher Site
http://dx.doi.org/10.1002/dta.338DOI Listing
July 2012
15 Reads

Plant poisons: their occurrence, biochemistry and physiological properties.

Authors:
Margaret Vickery

Sci Prog 2010 ;93(Pt 2):181-221

Butterfly Conservation Warwickshire, Kenilworth, Warwickshire, UK.

Plants produce poisons as a defence against predators. Many of these substances are biosynthesised from non-protein amino acids by biosynthetic pathways which have been deduced from the results of isotopic tracer analysis. These secondary metabolites have been used by humans over thousands of years, both as drugs and as agents to kill animals and commit homicide. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3184/003685010X12729948220326DOI Listing
August 2010
13 Reads

An unusual case of anisocoria by vegetal intoxication: a case report.

Ital J Pediatr 2010 Jul 20;36:50. Epub 2010 Jul 20.

U,O,C Pediatria Generale Dipartimento di Medicina Pediatrica, Ospedale Pediatrico Bambino Gesù, P,zza Sant'Onofrio 4, 00165 Roma, Italy.

A 12 year old boy presented with an acute onset of anisocoria and blurred vision. Ocular motility was normal but his right pupil was dilated, round but sluggishly reactive to light. There was no history of trauma, eye drops' instillation, nebulised drugs or local ointments. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1824-7288-36-50DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2914661PMC
July 2010
21 Reads

Aspects of Datura poisoning and treatment.

Clin Toxicol (Phila) 2010 Feb;48(2):104-10

Department of Pharmacy and Therapeutics, Pittsburgh Poison and Drug Information Center, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3109/15563651003630672DOI Listing
February 2010
11 Reads

Mass intoxication with Datura innoxia--case series and confirmation by analytical toxicology.

Clin Toxicol (Phila) 2010 Feb;48(2):143-5

Department of Forensic Medicine and Toxicology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

Background: Anticholinergic plants contain a variety of alkaloids that are toxic if ingested. Datura innoxia belongs to the family of Solanaceae and contains two main toxic alkaloids, atropine and scopolamine.

Case Series: In this study we report the case series of seven individuals who were admitted to two different hospitals of Athens with an anticholinergic syndrome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3109/15563650903524134DOI Listing
February 2010
27 Reads

Carbamate poisoning in a dairy goat herd: clinicopathological findings and therapeutic approach.

N Z Vet J 2009 Dec;57(6):392-4

Clinic of Farm Animals, School of Veterinary Medicine, Aristotle University of Thessaloniki, 11 St Voutyra Street, 546 27 Thessaloniki, Greece.

Case History: Approximately 1 hour after the consumption of carnations from a nearby glasshouse 55 animals from a dairy goat herd exhibited signs of possible poisoning.

Clinical Findings: Upon clinical examination affected animals exhibited signs of salivation, tympany, tachypnoea, polydipsia, urination, diarrhoea, bradycardia, miosis, tremor and convulsions. As poisoning from an acetylcholinesterase-inhibiting insecticide was suspected, treatment with atropine sulphate was initiated at a dose of 0. Read More

View Article

Download full-text PDF

Source
http://www.tandfonline.com/doi/abs/10.1080/00480169.2009.647
Publisher Site
http://dx.doi.org/10.1080/00480169.2009.64735DOI Listing
December 2009
50 Reads

Zigadenus poisoning treated with atropine and dopamine.

J Med Toxicol 2009 Dec;5(4):214-7

Oregon Health and Science University, Oregon Poison Center, Portland, OR 97239, USA.

Introduction: Zigadenus (commonly known as "death camas" or "mountain camas") is a common plant in the lily family found throughout the United States. Its onion-like roots can be mistaken for an edible plant. Ingestion may cause hemodynamic instability which has successfully been treated with atropine. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3550413PMC
http://dx.doi.org/10.1007/BF03178270DOI Listing
December 2009
25 Reads

Atrioventricular block induced by mad-honey intoxication: confirmation of diagnosis by pollen analysis.

Tex Heart Inst J 2009 ;36(4):342-4

Department of Cardiology, Ankara Turkiye Yuksek Ihtisas Hospital, Ankara, Turkey.

An unusual type of food poisoning, mad-honey intoxication, can be observed in the Black Sea region of Turkey and various other parts of the world. It can occur after ingestion of grayanotoxin-contaminated honey produced from the nectar of Rhododendron ponticum and other plant species, chiefly of the Ericaceae and Sapindaceae families. Mad-honey intoxication can result in severe cardiac complications, such as complete atrioventricular block. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720281PMC
October 2009
123 Reads

Plasma level of atropine after accidental ingestion of Atropa belladonna.

Clin Toxicol (Phila) 2009 Jul;47(6):602-4

Central Institute of the Bundeswehr Medical Service, München, Germany. reinhardbogan@ bundeswehr.org

Background: Ingestion of toxic plant constituents still poses a challenge in clinical management. The amount of berries ingested is often unclear and in the case of Atropa belladonna may affect clinical outcome. Plasma levels of atropine may thus be useful in confirming the cause of intoxication. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15563650903058906DOI Listing
July 2009
18 Reads

Solanum erianthum intoxication mimicking an acute cerebrovascular disease.

Am J Emerg Med 2009 Feb;27(2):249.e1-2

Department of Emergency Medicine, Mackay Memorial Hospital, Taipei 10449, Taiwan.

We describe a case of Solanum erianthum poisoning that happened to a 75-year-old man. He ate the S erianthum that he gathered from the countryside, believing that it would be helpful in improving the numbness of his distal limbs. S erianthum is a solanaceous plant that contains a variable concentration of solanum alkaloids, causing gastrointestinal irritation, and tropane alkaloids that have anticholinergic properties producing typical and sometimes severe atropinelike symptoms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajem.2008.05.026DOI Listing
February 2009
124 Reads

Acute anticholinergic syndrome from Atropa belladonna mistaken for blueberries.

Eur J Ophthalmol 2009 Jan-Feb;19(1):170-2

Ophthalmology Clinic, Department of Clinical Neurosciences, Geneva University Hospital, Geneva, Switzerland.

Purpose: To report the first case in the ophthalmic literature of acute anticholinergic syndrome after ingestion of Atropa belladonna mistaken for blueberries.

Methods: A 36-year-old woman presented to our ophthalmic emergency department with complaints of blurry vision, lightning flashes, disorientation, loss of balance, agitation, and anxiety for 24 hours. Ophthalmic examination revealed bilateral pupillary dilatation and paresis of accommodation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/112067210901900130DOI Listing
May 2009
19 Reads

Fatal injury in eastern Sri Lanka, with special reference to cardenolide self-poisoning with Cerbera manghas fruits.

Clin Toxicol (Phila) 2008 Sep;46(8):745-8

Scottish Poisons Information Bureau, Royal Infirmary of Edinburgh, and Clinical Pharmacology Unit, University of Edinburgh, United Kingdom.

Objective: Self-poisoning with plant seeds or fruits is a common method of self-harm in South Asia. While most deaths follow ingestion of Thevetia peruviana (yellow oleander) seeds, other plants are locally common. During review of fatal injuries seen in a teaching hospital in eastern Sri Lanka, we noted cases of fatal self-poisoning with Cerbera manghas (sea mango, pink eyed cerbera, odollam tree) fruits. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15563650701668617DOI Listing
September 2008
20 Reads

[Determination of hyoscyamine and scopolamine in serum and urine of humans by liquid chromatography with tandem mass spectrometry].

Shokuhin Eiseigaku Zasshi 2008 Aug;49(4):266-71

Fukuoka City Institute for Hygiene and the Environment. Funuoka, Japan.

A simple method was developed for the analysis of hyoscyamine and scopolamine in human serum and urine using liquid chromatography with tandem mass spectrometry (LC/MS/MS). Hyoscyamine and scopolamine in serum and urine were cleaned up with an Oasis HLB cartridge and a PSA cartridge. The LC separation was carried out on an ODS column, using linear gradient elution with 5 mmol/L IPCC-MS3-methanol as the mobile phase. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3358/shokueishi.49.266DOI Listing
August 2008
12 Reads

The comparative pathology of the glycosidase inhibitors swainsonine, castanospermine, and calystegines A3, B2, and C1 in mice.

Toxicol Pathol 2008 Jul 22;36(5):651-9. Epub 2008 May 22.

USDA-ARS, Poisonous Plant Research Laboratory, Logan, Utah 84321, USA.

To study various polyhydroxy-alkaloid glycosidase inhibitors, 16 groups of 3 mice were dosed using osmotic minipumps with swainsonine (0, 0.1, 1, and 10 mg/kg/day), castanospermine, and calystegines A(3), B(2), and C(1) (1, 10, and 100 mg/kg/day). After 28 days, the mice were euthanized, necropsied, and examined using light and electron microscopy. Read More

View Article

Download full-text PDF

Source
http://tpx.sagepub.com/content/early/2008/05/22/019262330831
Web Search
http://tpx.sagepub.com/cgi/doi/10.1177/0192623308317420
Publisher Site
http://dx.doi.org/10.1177/0192623308317420DOI Listing
July 2008
27 Reads

Unilateral mydriasis due to Angel's trumpet.

Clin Toxicol (Phila) 2008 Apr;46(4):329-31

Department of Pediatrics, University of Padova, Padova, Italy.

Introduction: There are many causes of bilateral and unilateral mydriasis. Common garden plants, such as Brugmansia (Angel's trumpet), contain tropane alkaloids.

Case Report: An 11-year-old girl was brought to the Emergency Department because of discomfort and difficulty with near vision in the left eye, accompanied by unilateral mydriasis (pupil approximately 8 mm, unresponsive to both papillary light reflex and accommodation reflex). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15563650701378720DOI Listing
April 2008
12 Reads

It could have happened to Van Gogh: a case of fatal purple foxglove poisoning and review of the literature.

Eur J Emerg Med 2007 Dec;14(6):356-9

Emergency Department, Northern General Hospital, Sheffield S5 7AU, UK.

Although death owing to the toxic effects of the therapeutic Digitalis lanata extract, digoxin has been reported, there are no reported cases of fatal Digitalis purpurea (digitoxin) plant intoxication in humans in the literature. We describe a case of ingestion of Digitalis purpurea in a 64-year-old man, which was fatal despite administration of Digibind. A review of the literature and aspects of management of plant digitalis poisoning are discussed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MEJ.0b013e3280bef8dcDOI Listing
December 2007
29 Reads

Solanaceae IV: Atropa belladonna, deadly nightshade.

Authors:
M R Lee

J R Coll Physicians Edinb 2007 Mar;37(1):77-84

Clinical Pharmacology and Therapeutics, University of Edinburgh, Edinburgh, Scotland.

The Deadly Nightshade, Atropa belladonna, is a plant surrounded by myth, fear and awe. In antiquity, the Greeks and the Romans knew that it contained a deadly poison. In medieval times, it was widely used by witches, sorcerors and professional poisoners. Read More

View Article

Download full-text PDF

Source
March 2007
15 Reads

Solanaceae III: henbane, hags and Hawley Harvey Crippen.

Authors:
M R Lee

J R Coll Physicians Edinb 2006 Dec;36(4):366-73

Clinical Pharmacology and Therapeutics, University of Edinburgh, Edinburgh, Scotland.

Hyoscyamus, the henbane, is one of the drugs of the ancients. Initially used both as a poison and narcotic, it was widely adopted by witches, wizards and soothsayers as a component of their hallucinatory and flying ointments. It was also used by notorious poisoners such as Madame Voisin in France. Read More

View Article

Download full-text PDF

Source
December 2006
8 Reads

The pharmacological properties of anisodamine.

J Appl Toxicol 2007 Mar-Apr;27(2):116-21

Physician Assistant Branch, Department of Medical Sciences, AMEDD Center and School, Ft. Sam Houston, Texas 78234, USA.

Anisodamine is a naturally occurring atropine derivative that has been isolated, synthesized and characterized by scientists in the People's Republic of China. Like atropine and scopolamine, anisodamine is a non-specific cholinergic antagonist exhibiting the usual spectrum of pharmacological effects of this drug class. It appears to be less potent and less toxic than atropine and displays less CNS toxicity than scopolamine. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jat.1154DOI Listing
April 2007
17 Reads

Confirmed Datura poisoning in a horse most probably due to D. ferox in contaminated tef hay.

J S Afr Vet Assoc 2006 Jun;77(2):86-9

Department of Animal Sciences, Faculty of Agricultural Sciences, Tshwane University of Technology, Private Bag X680, Pretoria 0001, South Africa.

Two out of a group of 23 mares exposed to tef hay contaminated with Datura ferox (and possibly D. stramonium) developed colic. The 1st animal was unresponsive to conservative treatment, underwent surgery for severe intestinal atony and had to be euthanased. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4102/jsava.v77i2.350DOI Listing
June 2006
13 Reads

Testing for atropine and scopolamine in hair by LC-MS-MS after Datura inoxia abuse.

J Anal Toxicol 2006 Sep;30(7):454-7

Laboratoire ChemTox, 3 rue Gruninger, 67400 Illkirch, France.

Datura inoxia belongs to the family of Solanaceae. This is a very common plant in New Caledonia that contains two main toxic alkaloids, l-atropine and l-scopolamine. In this study, we report the case of a 20-year-old male admitted to an Emergency Unit after consumption of 6 dried flowers in hot water for hallucinations, mydriasis, and agitation associated with tachycardia and increase of systolic blood pressure to 180. Read More

View Article

Download full-text PDF

Source
http://jat.oxfordjournals.org/content/30/7/454.full.pdf
Web Search
http://dx.doi.org/10.1093/jat/30.7.454DOI Listing
September 2006
65 Reads

The early toxicology of physostigmine: a tale of beans, great men and egos.

Authors:
Alex Proudfoot

Toxicol Rev 2006 ;25(2):99-138

National Poisons Information Service (Birmingham Centre), City Hospital, Birmingham, UK.

Mid-19th century European visitors to Old Calabar, an eastern province of Nigeria, could not avoid becoming aware of native belief in the power of the seeds of a local plant to determine whether individuals were innocent or guilty of some serious misdemeanour. The seeds were those of a previously unknown legume and soon referred to as the ordeal bean of Old Calabar. Their administration was known locally as 'chop nut'. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/content/pdf/10.2165/00139709-200625
Web Search
http://dx.doi.org/10.2165/00139709-200625020-00004DOI Listing
February 2007
22 Reads

Case report: acute unintentional carbachol intoxication.

Crit Care 2006 1;10(3):R84. Epub 2006 Jun 1.

Department of Pharmacology, University of Frankfurt, and Head, Center for Drug Information and Pharmacy Practice, ABDA-Federal Union of German Associations of Pharmacists, Jaegerstrasse 49/50, 10117 Berlin, Germany.

Introduction: Intoxications with carbachol, a muscarinic cholinergic receptor agonist are rare. We report an interesting case investigating a (near) fatal poisoning.

Methods: The son of an 84-year-old male discovered a newspaper report stating clinical success with plant extracts in Alzheimer's disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/cc4937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1550933PMC
October 2006
22 Reads

Anticholinergic syndrome due to 'Devil's herb': when risks come from the ancient time.

Int J Clin Pract 2006 Apr;60(4):492-4

Division of Emergency Medicine,Cannizzaro Hospital, Catania, Italy.

We describe a case of Mandragora autumnalis poisoning which occurred in a 72-year-old female patient who had eaten the venenous M. Autumnalis, picked near her home, mistaking it for the edible Borago Officinalis. M. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1368-5031.2006.00864.xDOI Listing
April 2006
8 Reads

Acute Erycibe henryi Prain ("Ting Kung Teng") poisoning.

Clin Toxicol (Phila) 2006 ;44(1):71-5

Department of Emergency Medicine, Taipei Veterans General Hospital and School of Medicine, National Yang-Ming University, Taiwan.

Erycibe henryi Prain ("Ting Kung Teng"), a species of Convolvulaceae, has been used in Chinese medicine to relieve pain involving the musculoskeletal system, such as arthritis, sciatica, and traumatic tissue swelling. E. henryi can be mistaken for another herbal plant, Tripterygium wilfordii Hook F, used to treat gouty arthritis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15563650500394902DOI Listing
March 2006
35 Reads

Intoxication by Ipomoea sericophylla and Ipomoea riedelii in goats in the state of Paraíba, Northeastern Brazil.

Toxicon 2006 Mar 20;47(4):371-9. Epub 2006 Feb 20.

Programa de Pós-Graduação em Ciência Veterinária, Universidade Rural de Pernambuco, CEP 52171-900, Recife PE, Brazil.

A disease of the nervous system was observed in goats from two farms of the semiarid of the state of Paraíba, northeastern Brazil. Ipomoea sericophylla was found in one farm and I. riedelii in the other. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.toxicon.2005.11.010DOI Listing
March 2006
10 Reads

Case report of a smuggler's dinner: carrots and asparagus, or bolitas?

Med Sci Monit 2005 Dec 24;11(12):CS79-81. Epub 2005 Nov 24.

Department of Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

Background: Body packing is a distinct method of drug smuggling. Surgeons and intensive care specialists will be confronted with body packers when packets do not pass spontaneously and rupture, causing drug toxicity.

Case Report: We report of a 32-year-old Liberian male who presented with abdominal complaints and anxiety after having ingested 50 cocaine-containing packets of which 49 had passed the natural route in the previous days. Read More

View Article

Download full-text PDF

Source
December 2005
14 Reads