1,056,477 results match your criteria Plant Poisoning Alkaloids – Tropane


Molecular Mechanisms of Plant Regeneration.

Annu Rev Plant Biol 2019 Feb 20. Epub 2019 Feb 20.

RIKEN Center for Sustainable Resource Science, Yokohama, Kanagawa 230-0045, Japan; email: , , , , , ,

Plants reprogram somatic cells following injury and regenerate new tissues and organs. Upon perception of inductive cues, somatic cells often dedifferentiate, proliferate, and acquire new fates to repair damaged tissues or develop new organs from wound sites. Wound stress activates transcriptional cascades to promote cell fate reprogramming and initiate new developmental programs. Read More

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http://dx.doi.org/10.1146/annurev-arplant-050718-100434DOI Listing
February 2019

A Molecular View of Plant Local Adaptation: Incorporating Stress-Response Networks.

Annu Rev Plant Biol 2019 Feb 20. Epub 2019 Feb 20.

Department of Plant Biology, Michigan State University, East Lansing, Michigan 48824, USA; email:

Ecological specialization in plants occurs primarily through local adaptation to different environments. Local adaptation is widely thought to result in costly fitness trade-offs that result in maladaptation to alternative environments. However, recent studies suggest that such trade-offs are not universal. Read More

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http://dx.doi.org/10.1146/annurev-arplant-050718-100114DOI Listing
February 2019

Chloroplast Lipids and Their Biosynthesis.

Annu Rev Plant Biol 2019 Feb 20. Epub 2019 Feb 20.

Institute of Molecular Physiology and Biotechnology of Plants (IMBIO), University of Bonn, 53115 Bonn, Germany; email:

Chloroplasts contain high amounts of monogalactosyldiacylglycerol (MGDG) and digalactosyldiacylglycerol (DGDG) and low levels of the anionic lipids sulfoquinovosyldiacylglycerol (SQDG), phosphatidylglycerol (PG), and glucuronosyldiacylglycerol (GlcADG). The mostly extraplastidial lipid phosphatidylcholine is found only in the outer envelope. Chloroplasts are the major site for fatty acid synthesis. Read More

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http://dx.doi.org/10.1146/annurev-arplant-050718-100202DOI Listing
February 2019

Thermomorphogenesis.

Annu Rev Plant Biol 2019 Feb 20. Epub 2019 Feb 20.

School of Biological Sciences, Monash University, Melbourne, VIC 3800, Australia; email:

When exposed to warmer, nonstressful average temperatures, some plant organs grow and develop at a faster rate without affecting their final dimensions. Other plant organs show specific changes in morphology or development in a response termed thermomorphogenesis. Selected coding and noncoding RNA, chromatin features, alternative splicing variants, and signaling proteins change their abundance, localization, and/or intrinsic activity to mediate thermomorphogenesis. Read More

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http://dx.doi.org/10.1146/annurev-arplant-050718-095919DOI Listing
February 2019

The Scope, Functions, and Dynamics of Posttranslational Protein Modifications.

Annu Rev Plant Biol 2019 Feb 20. Epub 2019 Feb 20.

Systembiologie der Pflanze, Universität Hohenheim, 70599 Stuttgart, Germany; email:

Assessing posttranslational modification (PTM) patterns within protein molecules and reading their functional implications present grand challenges for plant biology. We combine four perspectives on PTMs and their roles by considering five classes of PTMs as examples of the broader context of PTMs. These include modifications of the N terminus, glycosylation, phosphorylation, oxidation, and N-terminal and protein modifiers linked to protein degradation. Read More

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http://dx.doi.org/10.1146/annurev-arplant-050718-100211DOI Listing
February 2019

Molecular Interactions Between Plants and Insect Herbivores.

Annu Rev Plant Biol 2019 Feb 20. Epub 2019 Feb 20.

Department of Plant Molecular Biology, University of Lausanne, 1015 Lausanne, Switzerland; email:

Diverse molecular processes regulate the interactions between plants and insect herbivores. Here, we review genes and proteins that are involved in plant-herbivore interactions and discuss how their discovery has structured the current standard model of plant-herbivore interactions. Plants perceive damage-associated and, possibly, herbivore-associated molecular patterns via receptors that activate early signaling components such as Ca, reactive oxygen species, and MAP kinases. Read More

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http://dx.doi.org/10.1146/annurev-arplant-050718-095910DOI Listing
February 2019

Kratom exposures reported to United States poison control centers: 2011-2017.

Clin Toxicol (Phila) 2019 Feb 20:1-8. Epub 2019 Feb 20.

a Center for Injury Research and Policy , The Research Institute at Nationwide Children's Hospital , Columbus , OH , USA.

Context: Kratom, or Mitragyna speciosa, is a plant indigenous to Southeast Asia that has gained national attention in the United States for its increased use in the self-management of opioid withdrawal and pain, as well as for concerns about its safety.

Methods: This study analyzes exposures to kratom reported to poison control centers (PCCs) in the United States during 2011-2017 from the National Poison Data System (NPDS).

Discussion: From 2011 through 2017, 1807 kratom exposures were reported to United States PCCs. Read More

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http://dx.doi.org/10.1080/15563650.2019.1569236DOI Listing
February 2019

Gods associated with male fertility and virility.

Andrology 2019 Feb 20. Epub 2019 Feb 20.

Departamento de Cirurgia, Universidade Federal de Pernambuco, Recife, Brazil.

Background: Human fertility has always been a topic of curiosity and devotion. Many cultures consider fertility to be a necessity for the survival and perpetuation of mankind and since early times, myths were created to explain this fabulous process. Fertility gods were ubiquitous in numerous ancient human cultures and were used both to understand fertility and to cope with infertility by means of rituals and offerings. Read More

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http://dx.doi.org/10.1111/andr.12599DOI Listing
February 2019

Comprehensive mass spectrometry-guided plant specialized metabolite phenotyping reveals metabolic diversity in the cosmopolitan plant family Rhamnaceae.

Plant J 2019 Feb 20. Epub 2019 Feb 20.

Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California, 92093, United States.

Plants produce a myriad of specialized metabolites to overcome their sessile habit and combat biotic as well as abiotic stresses. Evolution has shaped specialized metabolite diversity, which drives many other aspects of plant biodiversity. However, until recently, large-scale studies investigating specialized metabolite diversity in an evolutionary context have been limited by the impossibility to identify chemical structures of hundreds to thousands of compounds in a time-feasible manner. Read More

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http://dx.doi.org/10.1111/tpj.14292DOI Listing
February 2019

The plastidial metabolite 2-C-methyl-D-erythritol-2,4-cyclodiphosphate modulates defense responses against aphids.

Plant Cell Environ 2019 Feb 20. Epub 2019 Feb 20.

Laboratory of Entomology, Wageningen University, PO Box 16, 6700AA, Wageningen, The Netherlands.

Feeding by insect herbivores such as caterpillars and aphids induces plant resistance mechanisms that are mediated by the phytohormones jasmonic acid (JA) and salicylic acid (SA). These phytohormonal pathways often crosstalk. Besides phytohormones, methyl-D-erythriol-2,4-cyclodiphosphate (MEcPP), the penultimate metabolite in the methyl-D-erythritol-4-phosphate (MEP) pathway, has been speculated to regulate transcription of nuclear genes in response to biotic stressors such as aphids. Read More

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http://dx.doi.org/10.1111/pce.13538DOI Listing
February 2019

Functional analysis finds differences on the muscle transcriptome of pigs fed an n-3 PUFA-enriched diet with or without antioxidant supplementations.

PLoS One 2019 20;14(2):e0212449. Epub 2019 Feb 20.

Interdepartmental Centre for Industrial Agrifood Research (CIRI- AGRO), University of Bologna, Cesena, Italy.

Supplementing pig diets with n-3 polyunsaturated fatty acids (n-3 PUFA) may produce meat products with an increased n-3 fatty acid content, and the combined antioxidants addition could prevent lipid oxidation in the feed. However, to date, the effects of these bioactive compounds at the molecular level in porcine skeletal muscle are mostly unknown. This study aimed to analyse changes in the Longissimus thoracis transcriptome of 35 pigs fed three diets supplemented with: linseed (L); linseed, vitamin E and Selenium (LES) or linseed and plant-derived polyphenols (LPE). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212449PLOS
February 2019

Introduction of the YTE mutation into the non-immunogenic HIV bnAb PGT121 induces anti-drug antibodies in macaques.

PLoS One 2019 20;14(2):e0212649. Epub 2019 Feb 20.

PlantVax Corporation, Rockville, Maryland United States of America.

Recombinant antibodies play increasingly important roles as immunotherapeutic treatments for human cancers as well as inflammatory and infectious diseases and have revolutionized their management. In addition, their therapeutic potential may be enhanced by the introduction of defined mutations in the crystallizable fragment (Fc) domains eg YTE (M252Y/S254T/T256E) and LS (M428L/N434S), as a consequence of increased half-lives and prolonged duration of protection. However, the functional properties of any biologic may be compromised by unanticipated immunogenicity in humans, rendering them ineffective. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212649PLOS
February 2019

Hydrogen gas promotes the adventitious rooting in cucumber under cadmium stress.

PLoS One 2019 20;14(2):e0212639. Epub 2019 Feb 20.

College of Horticulture, Gansu Agricultural University, Yinmen Village, Anning District, Lanzhou, PR China.

Hydrogen gas (H2) plays an important role in plant development and stress responses. Here, cucumber (Cucumis sativus L.) explants were used to investigate the roles of H2 in adventitious root development under cadmium (Cd) stress and its physiological mechanism. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212639PLOS
February 2019

Toxicity and oviposition deterrence of essential oils of Clinopodium nubigenum and Lavandula angustifolia against the myiasis-inducing blowfly Lucilia sericata.

PLoS One 2019 20;14(2):e0212576. Epub 2019 Feb 20.

Department of Agriculture, Food and Environment, University of Pisa, Pisa, Italy.

Cutaneous myiasis is a severe worldwide medical and veterinary issue. In this trial the essential oil (EO) of the Andean medicinal plant species Clinopodium nubigenum (Kunth) Kuntze was evaluated for its bioactivity against the myiasis-inducing blowfly Lucilia sericata (Meigen) (Diptera Calliphoridae) and compared with that of the well-known medicinal plant species Lavandula angustifolia Mill. The EOs were analysed and tested in laboratory for their oviposition deterrence and toxicity against L. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212576PLOS
February 2019

Biological soil crusts inhibit seed germination in a temperate pine barren ecosystem.

PLoS One 2019 20;14(2):e0212466. Epub 2019 Feb 20.

Department of Biological Sciences, Union College, Schenectady, New York, United States of America.

Biological soil crusts (BSCs) are known to affect plants' germination and seedling establishment in arid ecosystems, but their ecological role in more mesic climates is not so well-known. We tested the effects of moss-crusted versus uncrusted soils on seed germination dynamics in a temperate pine barren ecosystem. We conducted a 35-day laboratory assay of seed germination on moss-crusted soils versus uncrusted soils from the Albany (NY) Pine Bush Preserve. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212466PLOS
February 2019

Pesticide distribution and depletion kinetic determination in honey and beeswax: Model for pesticide occurrence and distribution in beehive products.

PLoS One 2019 20;14(2):e0212631. Epub 2019 Feb 20.

Department of Toxicology, Kimron Veterinary Institute, Bet Dagan, Israel.

Beehive products such as honey, beeswax and recently pollen have been regarded for many years as appropriate sentinels for environmental pesticide pollutions. However, despite yearly application of hundreds of approved pesticides in agricultural fields, only a minor fraction of these organic compounds were actually detected in honey and beeswax samples. This observation has led us to question the general suitability of beehive products as a sentinel for synthetic organic pesticides applied in the field. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212631PLOS
February 2019

Nitrogen- and phosphorus-starved Triticum aestivum show distinct belowground microbiome profiles.

PLoS One 2019 20;14(2):e0210538. Epub 2019 Feb 20.

Energy, Mining and Environment Research Centre, National Research Council Canada, Montréal, QC, Canada.

Many plants have natural partnerships with microbes that can boost their nitrogen (N) and/or phosphorus (P) acquisition. To assess whether wheat may have undiscovered associations of these types, we tested if N/P-starved Triticum aestivum show microbiome profiles that are simultaneously different from those of N/P-amended plants and those of their own bulk soils. The bacterial and fungal communities of root, rhizosphere, and bulk soil samples from the Historical Dryland Plots (Lethbridge, Canada), which hold T. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210538PLOS
February 2019

Moderate plant water stress improves larval development, and impacts immunity and gut microbiota of a specialist herbivore.

PLoS One 2019 20;14(2):e0204292. Epub 2019 Feb 20.

Organismal and Evolutionary Biology Research Programme, University of Helsinki, Helsinki, Finland.

While host plant drought is generally viewed as a negative phenomenon, its impact on insect herbivores can vary largely depending on the species involved and on the intensity of the drought. Extreme drought killing host plants can clearly reduce herbivore fitness, but the impact of moderate host plant water stress on insect herbivores can vary, and may even be beneficial. The populations of the Finnish Glanville fritillary butterfly (Melitaea cinxia) have faced reduced precipitation in recent years, with impacts even on population dynamics. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0204292PLOS
February 2019

The P5A ATPase Spf1p is stimulated by phosphatidylinositol 4-phosphate and influences cellular sterol homeostasis.

Mol Biol Cell 2019 Feb 20:mbcE18060365. Epub 2019 Feb 20.

Department of Plant and Environmental Sciences, University of Copenhagen, Thorvaldsensvej 40, DK-1871 Frederiksberg C, Denmark.

P5A ATPases are expressed in the endoplasmic reticulum (ER) of all eukaryotic cells, and their disruption results in severe ER stress. However, the function of these ubiquitous membrane proteins, which belong to the P-type ATPase superfamily, is unknown. We purified a functional tagged version of the Saccharomyces cerevisiae P5A ATPase Spf1p and observed that the ATP hydrolytic activity of the protein is stimulated by phosphatidylinositol 4-phosphate (PI4P). Read More

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http://dx.doi.org/10.1091/mbc.E18-06-0365DOI Listing
February 2019

Occurrence, Identification, and Antimicrobial Resistance Profiles of Extended-Spectrum and AmpC β-Lactamase-Producing Enterobacteriaceae from Fresh Vegetables Retailed in Gauteng Province, South Africa.

Foodborne Pathog Dis 2019 Feb 20. Epub 2019 Feb 20.

Department of Plant and Soil Sciences, University of Pretoria, Pretoria, South Africa.

Extended-spectrum β-lactamase (ESBL) and AmpC β-lactamase-producing Enterobacteriaceae are no longer restricted to the health care system, but represent increased risks related to environmental integrity and food safety. Fresh produce has been increasingly reported to constitute a reservoir of multidrug-resistant (MDR) potential human pathogenic Enterobacteriaceae. This study aimed to detect, identify, and characterize the antimicrobial resistance of ESBL/AmpC-producing Enterobacteriaceae isolates from fresh vegetables at point of sale. Read More

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http://dx.doi.org/10.1089/fpd.2018.2558DOI Listing
February 2019

Establishing CRISPR/Cas13a immune system conferring RNA virus resistance in both dicot and monocot plants.

Plant Biotechnol J 2019 Feb 20. Epub 2019 Feb 20.

Guangdong Province Key Laboratory of Microbial Signals and Disease Control, College of Agriculture, South China Agricultural University, Guangzhou, Guangdong, China.

Besides its powerful capability for genome editing, the clustered, regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) (CRISPR/Cas) systems, has been exploited to combat virus infection in eukaryotic organisms (Zaidi et al., 2016). By harnessing CRISPR/Cas system, its compelling inhibiting activities against DNA viruses (Ali et al. Read More

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http://dx.doi.org/10.1111/pbi.13095DOI Listing
February 2019

Experimental and modeling evidence of carbon limitation of leaf appearance rate for spring and winter wheat.

J Exp Bot 2019 Feb 20. Epub 2019 Feb 20.

LEPSE, Université Montpellier, INRA, Montpellier SupAgro, Montpellier, France.

Accurate predictions of the timing of physiological stages and the development rate are crucial for predicting crop performance under field conditions. Plant development is controlled by the leaf appearance rate (LAR) and our understanding of how LAR responds to environmental factors is still limited. Here, we tested the hypothesis that carbon availability may account for the effects of irradiance, photoperiod, atmospheric CO2 concentration, and ontogeny on LAR. Read More

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http://dx.doi.org/10.1093/jxb/erz012DOI Listing
February 2019

Oilfield Reclamation Recovers Productivity but not Composition of Arthropod Herbivores and Predators.

Environ Entomol 2019 Feb 20. Epub 2019 Feb 20.

USDA-ARS, Pest Management Research Unit, Sidney, MT.

Arthropods are key components of grassland ecosystems. Though arthropod communities are often strongly influenced by plant communities, plants and arthropods may respond differently to disturbance. Studying plant responses alone may, therefore, not fully capture altered ecosystem dynamics; thus multi-trophic approaches are critical to fully understand ecosystem responses to disturbance. Read More

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http://dx.doi.org/10.1093/ee/nvz012DOI Listing
February 2019

Kaempferol suppresses human gastric cancer SNU-216 cell proliferation, promotes cell autophagy, but has no influence on cell apoptosis.

Authors:
Fan Zhang Cuimei Ma

Braz J Med Biol Res 2019 Feb 14;52(2):e7843. Epub 2019 Feb 14.

Department of Gastroenterology, Affiliated Hospital of Jining Medical University, Jining, China.

Gastric cancer remains a serious threat to human health worldwide. Kaempferol is a plant-derived flavonoid compound with a wide range of pharmacological activities. This study aimed to investigate the effects of kaempferol on gastric cancer SNU-216 cell proliferation, apoptosis, and autophagy, as well as underlying potential mechanisms. Read More

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http://dx.doi.org/10.1590/1414-431X20187843DOI Listing
February 2019

Pyrophosphate modulates plant stress responses via SUMOylation.

Elife 2019 Feb 20;8. Epub 2019 Feb 20.

Department Cell Biology, Centre for Organismal Studies (COS), Heidelberg University, Heidelberg, Germany.

Pyrophosphate (PPi), a byproduct of macromolecule biosynthesis is maintained at low levels by soluble inorganic pyrophosphatases (sPPase) found in all eukaryotes. In plants, H-pumping pyrophosphatases (H-PPase) convert the substantial energy present in PPi into an electrochemical gradient. We show here, that both cold- and heat stress sensitivity of mutants lacking the major H-PPase isoform AVP1 is correlated with reduced SUMOylation. Read More

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http://dx.doi.org/10.7554/eLife.44213DOI Listing
February 2019

Frateuria defendens sp. nov., bacterium isolated from the yellows grapevine's disease vector Hyalesthes obsoletus.

Int J Syst Evol Microbiol 2019 Feb 20. Epub 2019 Feb 20.

1​Department of Entomology, Agricultural Research Organization, Newe Ya'ar Research Center, Ramat Yishay, Israel.

A Dyella-like bacterium was previously isolated from the planthopper Hyalesthes obsoletus (Hemiptera). Based on its 16S rRNA gene sequence, strain DHo was assigned to the family Rhodanobacteraceae with Dyella and Frateuria as its closest relatives. The closest 16S rRNA gene sequences were Frateuria aurantia DSM 6220 (98. Read More

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http://dx.doi.org/10.1099/ijsem.0.003305DOI Listing
February 2019

Genetic Diversity and Structure in Regional Cercospora beticola Populations from Beta vulgaris ssp. vulgaris Suggest Two Clusters of Separate Origin.

Phytopathology 2019 Feb 20. Epub 2019 Feb 20.

Cornell University, Department of Plant Pathology and Plant-Microbe Biology , Barton Laboratory , 630 West North Street , Geneva, New York, United States , 14456 ;

Cercospora leaf spot, caused by Cercospora beticola, is a highly destructive disease of Beta vulgaris ssp. vulgaris worldwide. Cercospora beticola populations are usually characterized by high genetic diversity, but little is known of the relationships among populations from different production regions around the world. Read More

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http://dx.doi.org/10.1094/PHYTO-07-18-0264-RDOI Listing
February 2019

Modeling epidemics in seed systems and landscapes to guide management strategies: The case of sweetpotato in Northern Uganda.

Phytopathology 2019 Feb 20. Epub 2019 Feb 20.

University of Florida, 3463 , Plant Pathology Department , Institute for Sustainable Food Systems , Emerging Pathogens Institute , Gainesville, Florida, United States , 32611-7011 ;

Seed systems are critical for deployment of improved varieties, but also can serve as major conduits for the spread of seed-borne pathogens. As in many other epidemic systems, epidemic risk in seed systems often depends on the structure of networks of trade, social interactions, and landscape connectivity. In a case study, we evaluated the structure of an informal sweetpotato seed system in the Gulu Region of Northern Uganda, for its vulnerability to the spread of emerging epidemics, and its utility for disseminating improved varieties. Read More

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http://dx.doi.org/10.1094/PHYTO-03-18-0072-RDOI Listing
February 2019

The Ptr1 locus of Solanum lycopersicoides confers resistance to race 1 strains of Pseudomonas syringae pv. tomato and to Ralstonia pseudosolanacearum by recognizing the type III effectors AvrRpt2/RipBN.

Mol Plant Microbe Interact 2019 Feb 20. Epub 2019 Feb 20.

Boyce Thompson Institute , Tower Rd , Ithaca, New York , Ithaca, New York, United States , 14853-1801 ;

Race 1 strains of Pseudomonas syringae pv. tomato, which cause bacterial speck disease of tomato, are becoming increasingly common and no simply-inherited genetic resistance to such strains is known. We discovered that a locus in Solanum lycopersicoides, termed Pseudomonas tomato race 1 (Ptr1), confers resistance to race 1 Pst strains by detecting the activity of type III effector AvrRpt2. Read More

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http://dx.doi.org/10.1094/MPMI-01-19-0018-RDOI Listing
February 2019

Ustilobisorbicillinol A, a Cytotoxic Sorbyl-Containing Aromatic Polyketide from Ustilaginoidea virens.

Org Lett 2019 Feb 20. Epub 2019 Feb 20.

Department of Plant Pathology, College of Plant Protection , China Agricultural University , Beijing 100193 , China.

Ustilobisorbicillinol A (1), which is a novel bisorbicillinoid featuring a unique cage structure that incorporates one sorbicillinol and one sorbyl-containing phenanthrenone unit, was isolated from the culture of Ustilaginoidea virens. Three biogenetically related new metabolites (2-4) were also isolated. Their structures were elucidated by extensive spectroscopic analyses, including the C NMR and electronic circular dichroism (ECD) calculations for the configurational assignment. Read More

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http://dx.doi.org/10.1021/acs.orglett.8b04101DOI Listing
February 2019

Resveratroloside Alleviates Postprandial Hyperglycemia in Diabetic Mice by Competitively Inhibiting a-Glucosidase.

J Agric Food Chem 2019 Feb 20. Epub 2019 Feb 20.

The regulation of postprandial blood glucose (PBG) levels is an effective therapeutic method to treat diabetes and prevent diabetes-related complications. Resveratroloside is a mono-glucosylated form of stilbene that is present in red wine, grapes and several traditional medicinal plants. In our study, the effect of resveratroloside on reducing PBG was studied in vitro and in vivo. Read More

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http://dx.doi.org/10.1021/acs.jafc.9b00455DOI Listing
February 2019

Chemical inhibition of Kir channels reduces salivary secretions and phloem feeding of the cotton aphid, Aphis gossypii (Glover).

Pest Manag Sci 2019 Feb 19. Epub 2019 Feb 19.

Louisiana State University AgCenter, Department of Entomology, Baton Rouge, LA 70803.

Background: The unique feeding biology of aphids suggests novel insecticide targets are likely to exist outside of the nervous system. Therefore, we aimed to directly test the hypothesis that pharmacological inhibition of inward rectifier potassium (Kir) channels would result in salivary gland failure and reduced sap ingestion by the cotton aphid, Aphis gossypii.

Results: The Kir inhibitors VU041 and VU590 reduced the length of the salivary sheath in a concentration dependent manner, indicating that the secretory activity of the salivary gland is reduced by Kir inhibition. Read More

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http://dx.doi.org/10.1002/ps.5382DOI Listing
February 2019

Antimicrobial and anti-biofilm properties of novel synthetic lignan-like compounds.

New Microbiol 2019 Feb 20;42(1). Epub 2019 Feb 20.

Department of Pharmacy, University of Naples Federico II, 80131, Italy.

Antibiotic resistance and biofilm tolerance are among the principal factors involved in the persistence of chronic infections. The need for new antimicrobials is an ever-increasing challenge in clinical environments and in the control of global health. Arylfurans form a set of structures that have been identified in many natural products, e. Read More

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February 2019

Starch deficiency in plant mutants and its influence on photosynthetic and post-photosynthetic carbon isotope fractionations.

J Exp Bot 2019 Feb 9. Epub 2019 Feb 9.

Institute of Agricultural Sciences, ETH Zurich, Universitaetsstrasse, Zurich, Switzerland.

Carbon isotope fractionations occurring during and after photosynthetic CO2 fixation shape the carbon isotope composition (δ13C) of plant material and respired CO2. However, responses of 13C fractionations to diel variation in the leaf starch metabolism are not fully understood. Here we measured δ13C of organic matter (δ13COM), concentrations and δ13C of potential respiratory substrates, δ13C of dark-respired CO2 (δ13CR), and gas-exchange in leaves of starch-deficient plastidial phosphoglucomutase (pgm) mutants and wild type plants of four species (Arabidopsis thaliana, Mesembryanthemum crystallinum, Nicotiana sylvestris, and Pisum sativum). Read More

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http://dx.doi.org/10.1093/jxb/erz045DOI Listing
February 2019

Silencing of NbCMT3s has pleiotropic effects on development by interfering with autophagy-related genes in Nicotiana benthamiana.

Plant Cell Physiol 2019 Feb 20. Epub 2019 Feb 20.

Department of Biology, National Changhua University of Education, No.1, Jin-De Road, Changhua, 500, Taiwan.

DNA methylation is a chromatin mark that has a crucial role in regulating gene expression. The chromomethylase (CMT) protein family is a plant-specific DNA methyltransferase (DNMT) that mediates growth and development. However, the roles of CMT3 in autophagy remain to be elucidated. Read More

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http://dx.doi.org/10.1093/pcp/pcz034DOI Listing
February 2019

The iron-sulfur protein NFU2 plays a predominant role in branched-chain amino acid synthesis in Arabidopsis roots.

J Exp Bot 2019 Feb 8. Epub 2019 Feb 8.

BPMP, CNRS, INRA, Montpellier SupAgro, Univ Montpellier, Montpellier, France.

Numerous proteins require a metallic cofactor for their function. In plastids, the maturation of iron-sulfur (Fe-S) proteins necessitates a complex assembly machinery. We focused on Arabidopsis thaliana NFU1, NFU2 and NFU3, which participate in the late maturation steps. Read More

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http://dx.doi.org/10.1093/jxb/erz050DOI Listing
February 2019

Morelloflavone as a novel inhibitor of mitotic kinesin Eg5.

J Biochem 2019 Feb 20. Epub 2019 Feb 20.

Graduate School of Fisheries and Environmental Sciences, Nagasaki University, Nagasaki, Japan.

Among forty plant-derived biflavonoids with inhibitory potential against Eg5, morelloflavone from Garcinia dulcis leaves was selected for further testing based on in silico analysis of binding modes, molecular interactions, binding energies, and functional groups that interact with Eg5. Computational models predicted that morelloflavone binds the putative allosteric pocket of Eg5, within the cavity surrounded by amino acid residues of Ile-136, Glu-116, Glu-118, Trp-127, Gly-117, Ala-133, Glu-215, Leu-214, and Tyr-211. Binding energy was -8. Read More

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http://dx.doi.org/10.1093/jb/mvz015DOI Listing
February 2019

Antitumor Activity of Asiaticoside Against Multiple Myeloma Drug-Resistant Cancer Cells Is Mediated by Autophagy Induction, Activation of Effector Caspases, and Inhibition of Cell Migration, Invasion, and STAT-3 Signaling Pathway.

Med Sci Monit 2019 Feb 20;25:1355-1361. Epub 2019 Feb 20.

Department of Hematology, Shengjing Hospital, China Medical University, Shenyang, Liaoning, China (mainland).

BACKGROUND Accumulating evidence suggests that plant-derived molecules may prove extremely beneficial in the development of chemotherapy for deadly cancer types. Multiple myeloma is a rare and incurable type of cancers. Very little research has been directed towards the development of chemotherapy for the management of multiple myeloma. Read More

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http://dx.doi.org/10.12659/MSM.913397DOI Listing
February 2019

Purification of chlorogenic acid from Heijingang potatoes and evaluation of its binding properties to recombinant human serum albumin.

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Feb 11;1110-1111:87-93. Epub 2019 Feb 11.

Hubei Key Laboratory of Edible Wild Plants Conservation and Utilization, Hubei Normal University, Huangshi 435002, Hubei Province, China; National Demonstration Center for Experimental Biology Education, Hubei Normal University, Huangshi 435002, Hubei Province, China.

The aim of the present study was to purify the natural chlorogenic acid (CGA) monomer from Heijingang potatoes and investigate its interaction with recombinant human serum albumin (rHSA). The potato extract (PE) was purified using macroporous resins and solvent, and the CGA monomer was subsequently isolated using semipreparative liquid chromatography (SP-LC). The purity and structure of the CGA monomer was analyzed by high-performance liquid chromatography (HPLC) and nuclear magnetic resonance (NMR). Read More

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http://dx.doi.org/10.1016/j.jchromb.2019.02.010DOI Listing
February 2019

Investigation on apposite chemical marker for quality control of Tephrosia purpurea (L.) Pers. by means of HPTLC-chemometric analysis.

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Feb 8;1110-1111:81-86. Epub 2019 Feb 8.

B.V. Patel Pharmaceutical Education and Research Development (PERD) Centre, Thaltej, Ahmedabad 380054, India. Electronic address:

Application of phytochemicals as the markers for quality assurance of the herbal medicinal material is one of the prominently used approach. In the present study, six major chemical compounds i.e. Read More

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http://dx.doi.org/10.1016/j.jchromb.2019.02.006DOI Listing
February 2019

Caffeic acid derivatives isolated from Galinsoga parviflora herb protected human dermal fibroblasts from UVA-radiation.

Phytomedicine 2018 Dec 17;57:215-222. Epub 2018 Dec 17.

Department of Pharmacognosy and Molecular Basis of Phytotherapy, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland.

Background: Among solar radiation, ultraviolet light is the most harmful for the skin, because of intracellular reactive oxygen species formation, leading to oxidative stress, cell damage and apoptosis. Crucial role in skin protection against oxidative stress play antioxidant enzymes regulated by Nrf2 transcription factor. Some plant-derived polyphenols are known to protect skin fibroblasts against UV through induction of Nrf2-dependent antioxidant genes expression. Read More

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http://dx.doi.org/10.1016/j.phymed.2018.12.022DOI Listing
December 2018

Radiosensitivity and mutability of wheat seed progeny cultivated under adverse environments.

Plant Physiol Biochem 2019 Feb 14;137:162-168. Epub 2019 Feb 14.

Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Lavrentjeva ave. 10, Novosibirsk, 630090, Russia; N.I. Vavilov All-Russian Research Institute of Plant Genetic Resources (VIR), B. Morskaya str., 42-44, St. Petersburg, 190000, Russia.

This research analysed the growth process dynamics of soft wheat (Triticum aestivum L.) seeds cultivated in contrasting microclimatic conditions. We used acute gamma irradiation (5-50 Gy) as a provocative factor to detect hidden differences in the adaptive potential of seeds cultivated under adverse conditions (wet and cool field season) in comparison to seeds obtained under controlled conditions (hydroponic greenhouse). Read More

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http://dx.doi.org/10.1016/j.plaphy.2019.02.011DOI Listing
February 2019

Effects of cytokinins, gibberellic acid 3, and gibberellic acid 4/7 on in vitro growth, morphological traits, and content of steviol glycosides in Stevia rebaudiana.

Plant Physiol Biochem 2019 Feb 12;137:154-161. Epub 2019 Feb 12.

Department of Biology, Faculty of Arts and Sciences, Bolu Abant Izzet Baysal University, Bolu, Turkey. Electronic address:

Steviol glycosides (SGs) and gibberellic acids share a part of their biosynthesis pathways. Despite the widespread studies on the effect of gibberellic acid 3 (GA), the effect of gibberellic acid 4 and 7 (GA) on Stevia rebaudiana has never been studied. This study aimed at a comparative evaluation of different hormone effects, i. Read More

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http://dx.doi.org/10.1016/j.plaphy.2019.02.009DOI Listing
February 2019

Selenium protects wheat seedlings against salt stress-mediated oxidative damage by up-regulating antioxidants and osmolytes metabolism.

Plant Physiol Biochem 2019 Feb 8;137:144-153. Epub 2019 Feb 8.

Botany Department, Faculty of Science, Tanta University, Tanta, Egypt; Sainsbury Laboratory, University of Cambridge, Cambridge, United Kingdom.

Salinity stress hampers the growth of most crop plants and reduces yield considerably. Therefore, experiments were conducted on wheat (Triticum aestivum L.) plants for studying the role of selenium (5 and 10 μM Se) supplementation in strengthening the salinity stress tolerance. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09819428193005
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http://dx.doi.org/10.1016/j.plaphy.2019.02.004DOI Listing
February 2019
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The detoxification effect of liquid digestate on vanadium toxicity to seed germination and seedling growth of dog's tail grass.

J Hazard Mater 2019 Jan 28;369:456-464. Epub 2019 Jan 28.

School of Environment, Tsinghua University, Beijing 100084, China.

Dog's tail grass (Setaria viridis) presented strong tolerance and high accumulation of vanadium in field conditions. Liquid digestate containing high levels of nutrients could alleviate vanadium toxicity and accelerate the growth of dog's tail grass. To elucidate the detoxification potential and mechanism of liquid digestate, dog's tail grass was grown in soil solution containing 0. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2019.01.091DOI Listing
January 2019

Pesticide mediated oxidative stress induces genotoxicity and disrupts chromatin structure in fenugreek (Trigonella foenum - graecum L.) seedlings.

J Hazard Mater 2019 Feb 15;369:362-374. Epub 2019 Feb 15.

Department of Botany, UGC Center for Advanced Studies, The University of Burdwan, Golapbag Campus, Burdwan, 713 104, West Bengal, India. Electronic address:

Here we report cytototoxic and genotoxic potentials of four commonly used pesticides, including, tricyclazole, thiabendazole (fungicides), plethora and slash-360 (insecticides) in the non-target tropical crop plant Trigonella foenum - graecum L. (fenugreek). Three different concentrations of the selected pesticides were used. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2019.02.056DOI Listing
February 2019

A random object-oriented population study of household paints measured by infrared spectroscopy.

Forensic Sci Int 2019 Feb 7;297:72-80. Epub 2019 Feb 7.

University of Quebec at Trois-Rivières, Canada; Laboratoire de recherche en criminalistique, Trois-Rivières, Canada; Centre international de criminologie comparée, Montreal, Canada. Electronic address:

Forensic paint analysis heavily relies on population studies and creation of databases for estimating frequencies of apparition and perform discrimination studies. An important part of the paint market is currently led by household paints, that can be recovered in cases of burglaries of forced entries. Here, we present a database of 166 household paint samples collected at random in a waste recycling plant, and measured by infrared spectroscopy. Read More

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http://dx.doi.org/10.1016/j.forsciint.2019.01.045DOI Listing
February 2019

Vindoline effectively ameliorated diabetes-induced hepatotoxicity by docking oxidative stress, inflammation and hypertriglyceridemia in type 2 diabetes-induced male Wistar rats.

Biomed Pharmacother 2019 Feb 20;112:108638. Epub 2019 Feb 20.

Department of Biomedical Sciences, Phytomedicine and Phytochemistry Research Group, Oxidative Stress Research Centre, Faculty of Health & Wellness Sciences, Cape Peninsula University of Technology, P.O. Box 1906, Bellville, 7535, South Africa. Electronic address:

Vindoline, an indole alkaloid present in the leaves of Catharanthus roseus plant, has been recently reported to have insulotropic effects. This present study evaluated the possible hepatoprotective effects of vindoline in a type 2 diabetes mellitus rat model. Diabetes mellitus was induced by exposing rats to 10% fructose water for two weeks followed by a single intraperitoneal injection of 40 mg/kg body weight of streptozotocin (STZ). Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108638DOI Listing
February 2019

BW18, a C-21 steroidal glycoside, exerts an excellent anti-leukemia activity through inducing S phase cell cycle arrest and apoptosis via MAPK pathway in K562 cells.

Biomed Pharmacother 2019 Feb 19;112:108603. Epub 2019 Feb 19.

The State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academic of Sciences, Guiyang 550014, China. Electronic address:

C-21 steroids displayed the activities of immunosuppressive, anti-inflammatory and anti-virus effects by the reports. However, its antitumor effects and molecular mechanism remain unclear. We previously isolated and identified a C-21 steroidal glycoside (BW18) from the root of Cynanchum atratum Bunge. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108603DOI Listing
February 2019

Evaluation of biochemical mechanisms of anti-diabetic functions of Anisomeles malabarica.

Biomed Pharmacother 2019 Feb 19;112:108598. Epub 2019 Feb 19.

Department of Biochemistry, Sri Venkateswara University, Tirupati, AP, India. Electronic address:

Anisomeles malabarica (AM) is an aromatic plant traditionally used for the treatment of diabetes mellitus in India. Following bioassay guided fractionation, we recently identified an active fraction of AM (AMAF, with potential mix of active principles) that showed significant antihyperglycemic and antihyperlipidemic activities. In addition, AMAF treatment improved insulin levels. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.01.059DOI Listing
February 2019
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