10,287 results match your criteria Plague


Exposure to Yersinia pestis increases resistance to plague in black rats and modulates transmission in Madagascar.

BMC Res Notes 2018 Dec 14;11(1):898. Epub 2018 Dec 14.

Unité d'Immunologie, Institut Pasteur de Madagascar, Ambatofotsikely, P.O. Box 1274, Antananarivo, Madagascar.

Objectives: In Madagascar, plague (Yersinia pestis infection) is endemic in the central highlands, maintained by the couple Rattus rattus/flea. The rat is assumed to die shortly after infection inducing migration of the fleas. However we previously reported that black rats from endemic areas can survive the infection whereas those from non-endemic areas remained susceptible. Read More

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December 2018

Differential gene expression for carotenoid biosynthesis in a green alga Ulva prolifera based on transcriptome analysis.

BMC Genomics 2018 Dec 13;19(1):916. Epub 2018 Dec 13.

Department of Cell Biology, College of Biology and Basic Medical Sciences, Soochow University, No. 199 Renai Road, SIP, Suzhou, 215123, China.

Background: Carotenoids are widely distributed in plants and algae, and their biosynthesis has attracted widespread interest. Carotenoid-related research has mostly focused on model species, and there is a lack of data on the carotenoid biosynthetic pathway in U. prolifera that is the main species leading to green tide, a harmful plague of floating green algae. Read More

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December 2018

A survey on endoparasites in wild rodents of the Jaz Murian depression and adjacent areas, southeast of Iran.

J Parasit Dis 2018 Dec 13;42(4):589-597. Epub 2018 Oct 13.

Department of Plant Protection, Faculty of Agriculture, Higher Educational Complex of Saravan, Saravan, Iran.

In this survey, rodents and their endoparasites were investigated in the Jaz Murian depression and adjacent areas, southeast Iran. In total, 146 specimens of rodents belong to 13 species were trapped. In general, 10 different genera of endoparasites including 11 species were collected. Read More

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December 2018

There and back again - The journey of LiNiO₂ as cathode active material.

Angew Chem Int Ed Engl 2018 Dec 10. Epub 2018 Dec 10.

Universität Gießen, Heinrich-Buff-Ring 58, 35392, Gießen, GERMANY.

LiNiO₂ (LNO) has been introduced as cathode active material (CAM) for Li-ion batteries in 1990. After years of intensive research, it emerged that several instability issues plague the material, so that it was abandoned in favor of isostructural metal-substituted compounds called NCA (for lithium nickel cobalt aluminum oxide) and NCM (lithium nickel cobalt manganese oxide). These sacrifice a certain amount of specific energy in exchange for stability, durability and safety. Read More

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December 2018

Emergence and Spread of Basal Lineages of Yersinia pestis during the Neolithic Decline.

Cell 2018 Dec 5. Epub 2018 Dec 5.

Department of Bio and Health Informatics, Technical University of Denmark, Kemitorvet 208, 2800 Kongens Lyngby, Denmark. Electronic address:

Between 5,000 and 6,000 years ago, many Neolithic societies declined throughout western Eurasia due to a combination of factors that are still largely debated. Here, we report the discovery and genome reconstruction of Yersiniapestis, the etiological agent of plague, in Neolithic farmers in Sweden, pre-dating and basal to all modern and ancient known strains of this pathogen. We investigated the history of this strain by combining phylogenetic and molecular clock analyses of the bacterial genome, detailed archaeological information, and genomic analyses from infected individuals and hundreds of ancient human samples across Eurasia. Read More

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December 2018

A critical review of anthropological studies on skeletons from European plague pits of different epochs.

Sci Rep 2018 Dec 5;8(1):17655. Epub 2018 Dec 5.

Department of Biomedical and Specialty Surgical Sciences, University of Ferrara, Ferrara, Italy.

In historical times, plague epidemics intermittently ravaged Europe for more than 1,400 years, and still represent a threat in many countries all over the world. A debate is ongoing about the past plague, if it killed randomly in a population or discriminated among persons on the basis of their biological features. To address questions of plague lethality, we reviewed a large number of anthropological studies published in the last twenty years on victims of the past pestilences in Europe. Read More

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December 2018
1 Read

History, evolution and future of environmental health in Uganda.

Arch Environ Occup Health 2018 Dec 3:1-10. Epub 2018 Dec 3.

a Department of Disease Control and Environmental Health , School of Public Health, College of Health Sciences, Makerere University , Kampala , Uganda.

This article explores the history and evolution of Environmental Health in Uganda under four key themes: training and practice; research; governance, policy and regulatory framework; and challenges. The article also describes the future of the profession. Through a review of documents and key informant interviews, it is noted that Environmental Health in Uganda dates back to colonial times when the country was affected by diseases including plague, trypanosomiasis and small pox. Read More

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December 2018
1 Read

Metabolic Biomarkers of Aging and Aging-related Diseases in Chinese Middle-Aged and Elderly Men.

J Nutr Health Aging 2018 ;22(10):1189-1197

Prof. Meilin Liu, Department of Geriatrics, Peking University First Hospital; No. 8 Xishiku Street, Xicheng District, Beijing 100034, China, E-mail address:

Background: Aging is an acknowledged risk factor for most chronic diseases and functional impairments. The practicability of potential biomarkers of aging remains unsure. Moreover, biomarkers related to certain geriatric diseases, such as carotid atherosclerosis and multiple co-morbidities are less understood. Read More

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January 2018
2 Reads

Escherichia coli expressed flagellin C (FliC) of Salmonella Typhi improved the protective efficacy of YopE against plague infection.

Vaccine 2019 Jan 26;37(1):19-24. Epub 2018 Nov 26.

Microbiology Division, Defence Research & Development Establishment, Jhansi Road, Gwalior 474002, India.

In the current antibiotic resistance scenario, vaccines may provide best defense against lethal bacterial diseases. So far, there is no idealvaccine available against plague. Despite providing complete protection in small animal models, F1/LcrV based vaccine failed to provide ideal protection in non human primates. Read More

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January 2019
1 Read

Oligopeptide derived from solid-state fermented cottonseed meal significantly affect the immunomodulatory in BALB/c mice treated with cyclophosphamide.

Food Sci Biotechnol 2018 Dec 20;27(6):1791-1799. Epub 2018 Jun 20.

1College of Animal Science and Technology, Shihezi University, North Street 4, 832000 Shihezi, China.

In this study, the immunomodulatory activity of oligopeptide (CP) derived from solid-state fermented cottonseed meal were investigated in immunosuppressed BALB/c mice models by treatment with cyclophosphamide (CY). Results indicated that oligopeptide increased the thymus and spleen indices of CY-treated mice. The count of plague forming cells (PFC) and the content of half serum hemolysis (HC) in immunosuppressive mice were restored to the normal level in CP-10 and CP-20 groups while the cytokines interleukin (IL)-2, IL-6, and tumor necrosis factor alpha (TNF-α) were increased significantly in CP-20 group. Read More

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December 2018
2 Reads

A case report of human tularemia from Iran.

Iran J Microbiol 2018 Aug;10(4):250-253

National Reference Laboratory for Plague, Tularemia and Q Fever, Research Centre for Emerging and Reemerging Infectious Diseases, Pasteur Institute of Iran, Akanlu, Kabudar Ahang, Hamadan, Iran.

Tularemia is one of the most contagious bacterial infections. Here, we report a human case of glandular tularemia in Iran following the first report in 1980. The patient was a 6-year-old girl who had consumed a hunted hare in Kurdistan Province in western Iran. Read More

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August 2018
1 Read

Integrative approach using genomes to revisit the historical landscape of plague during the Medieval Period.

Proc Natl Acad Sci U S A 2018 Dec 26;115(50):E11790-E11797. Epub 2018 Nov 26.

Centre for Ecological and Evolutionary Synthesis (CEES), Department of Biosciences, University of Oslo, N-0316 Oslo, Norway;

Over the last few years, genomic studies on , the causative agent of all known plague epidemics, have considerably increased in numbers, spanning a period of about 5,000 y. Nonetheless, questions concerning historical reservoirs and routes of transmission remain open. Here, we present and describe five genomes from the second half of the 14th century and reconstruct the evolutionary history of by reanalyzing previously published genomes and by building a comprehensive phylogeny focused on strains attributed to the Second Plague Pandemic (14th to 18th century). Read More

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December 2018
1 Read

Considerations in the Care of Non-Small-Cell Lung Cancer: The Value Imperative.

Oncology (Williston Park) 2018 11;32(11):534-40

Cancer costs in the United States continue to escalate at an alarming and unsustainable rate. These costs are not driven exclusively by a higher demand for services or by an aging population; rather, a number of systemic failures, highlighted by the Institute of Medicine (IOM), continue to plague our cancer care delivery systems and need to be rectified. Drug costs, plus expensive diagnostic tests, hospital admissions/readmissions, and unreasonable end-of-life care, combine to inflate the total cost of care. Read More

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November 2018
1 Read

Humoral and cellular immune correlates of protection against bubonic plague by a live Yersinia pseudotuberculosis vaccine.

Vaccine 2019 Jan 19;37(1):123-129. Epub 2018 Nov 19.

Unité de Recherche Yersinia, Institut Pasteur, 25-28 rue du Dr Roux, 75724 Paris Cedex 15, France. Electronic address:

Immunization with the live-attenuated Yersinia pseudotuberculosis VTnF1 strain producing a Yersinia pestis F1 pseudocapsule efficiently protects mice against bubonic and pneumonic plague. In clinical trials, demonstration of a plague vaccine's efficacy in humans will not be feasible, and correlates of protection will be needed to bridge the immune response of protected animals to that of vaccinated humans. Using serum transfer and vaccination of antibody-deficient µMT mice, we established that both humoral and cellular responses elicited by VTnF1 independently conferred protection against bubonic plague. Read More

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January 2019
4 Reads

Analysing single-molecule trajectories to reconstruct free-energy landscapes of cyclic motor proteins.

J Theor Biol 2018 Nov 19;462:321-328. Epub 2018 Nov 19.

Scion, Private Bag 3020, Rotorua 3046, New Zealand.

Stochastic trajectories measured in single-molecule experiments have provided key insights into the microscopic behaviour of cyclic motor proteins. However, the fundamental free-energy landscapes of motor proteins are currently only able to be determined by computationally intensive numerical methods that do not take advantage of available single-trajectory data. In this paper we present a robust method for analysing single-molecule trajectories of cyclic motor proteins to reconstruct their free-energy landscapes. Read More

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November 2018
1 Read

MicroRNA-485 Modulates the TGF-β/ Smads Signaling Pathway in Chronic Asthmatic Mice by Targeting Smurf2.

Cell Physiol Biochem 2018 21;51(2):692-710. Epub 2018 Nov 21.

Department of Anesthesiology, China-Japan Union Hospital of Jilin University, Changchun,

Background/aims: Chronic respiratory conditions continue to plague millions of people worldwide. We aimed to elucidate the detailed mechanisms of microRNA-485 (miR-485) in airway smooth muscle cell (ASMC) proliferation and apoptosis in chronic asthmatic mice.

Methods: A mouse model of chronic asthma was established. Read More

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December 2018
3 Reads

A review and illustrated description of Musca crassirostris, one of the most neglected haematophagous livestock flies.

Med Vet Entomol 2018 Nov 21. Epub 2018 Nov 21.

Department of Entomology, Faculty of Agriculture at Kamphaeng Saen, Kasetsart University, Nakhon Pathom, Thailand.

Tabanids, stomoxyine flies, hippoboscids and tsetse flies are the most well-known brachyceran biting flies of livestock. Only a few other higher Diptera have developed the unique mouthparts required for blood feeding. These neglected blood feeders can also have direct effects on hosts through blood loss, and are likely to contribute to the transmission of pathogens. Read More

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November 2018
2 Reads

Discovering RNA-Based Regulatory Systems for Virulence.

Front Cell Infect Microbiol 2018 25;8:378. Epub 2018 Oct 25.

Department of Molecular Infection Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany.

The genus includes three human pathogenic species, , the causative agent of the bubonic and pneumonic plague, and enteric pathogens and that cause a number of gut-associated diseases. Over the past years a large repertoire of RNA-based regulatory systems has been discovered in these pathogens using different RNA-seq based approaches. Among them are several conserved or species-specific RNA-binding proteins, regulatory and sensory RNAs as well as various RNA-degrading enzymes. Read More

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October 2018
3 Reads

Estimation of Pneumonic Plague Transmission in Madagascar, August-November 2017.

PLoS Curr 2018 Nov 1;10. Epub 2018 Nov 1.

Computational Epidemiology Group, Division of Emergency Medicine, Boston Children's Hospital, Boston, MA, United States; Department of Pediatrics, Harvard Medical School, Boston Children's Hospital, Boston, MA, United States.

Introduction: Between August and November 2017, Madagascar reported nearly 2500 cases of plague; the vast majority of these cases were pneumonic, resulting in early exponential growth due to person-to-person transmission. Though plague is endemic in Madagascar, cases are usually bubonic and thus result in considerably smaller annual caseloads than those observed from August-November 2017.

Methods: In this study, we consider the transmission dynamics of pneumonic plague in Madagascar during this time period, as well as the role of control strategies that were deployed to curb the outbreak and their effectiveness. Read More

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November 2018
4 Reads

Sequencing and genetic characterization of two strains Paramushir virus obtained from the Tyuleniy Island in the Okhotsk Sea (2015).

Ticks Tick Borne Dis 2018 Nov 12. Epub 2018 Nov 12.

Saint-Petersburg Pasteur Institute, Center, Federal Service on Consumers' Rights Protection and Human Well-Being Surveillance, Saint-Petersburg, Russia; Martsinovsky Institute of Medical Parasitology, Tropical and Vector Borne Diseases, Sechenov First Moscow State Medical University, Moscow, Russia. Electronic address:

Paramushir virus belongs to Sakhalin virus genogroup within Orthonairovirus genus and is one of the poorly studied viruses with unknown pathogenicity. At the moment, only one nearly complete sequence of Paramushir virus genome, isolated in 1972, is available. Two new strains of PARV were isolated in 2015 from a sample collected at the Tyuleniy Island in the Okhotsk Sea and sequenced using a combination of high throughput sequencing and specific multiplex PCR. Read More

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November 2018
4 Reads

Problematizing the age friendly cities and communities program in Toronto.

Authors:
Meghan Joy

J Aging Stud 2018 Dec 30;47:49-56. Epub 2018 Oct 30.

Department of Political Science, Concordia University, 1455 de Maisonneuve Blvd. West, Hall Building, Montreal H3G 1M8, Canada. Electronic address:

This article contributes to the literature on Age Friendly Cities and Communities (AFCC) through a poststructural policy analysis of the program in Toronto. The purpose is to propose an approach, rooted in the study of public policy, that can offer a political interrogation into the problems plaguing AFCCs in practice. The approach centres on a basic question: what problem are AFCCs in Toronto intended to solve? A discourse analysis is undertaken on this problematization, using Toronto's age-friendly policy and 77 qualitative interview transcripts with policy actors as key texts. Read More

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December 2018
3 Reads

Plague Masks: The Visual Emergence of Anti-Epidemic Personal Protection Equipment.

Med Anthropol 2018 Aug-Sep;37(6):442-457. Epub 2018 Nov 14.

a Department of Social Anthropology , University of St Andrews , Fife , Scotland , United Kingdom.

Often described as "masks" face-worn devices are employed as personal protection equipment by health workers and the general public and considered to be an indispensable technology against epidemics. Simultaneously, they are potent symbols of existential risk. Could these material and visual aspects be more than simply indexically connected? In this article, I examine these apparatuses through a historical anthropological approach of their invention during the 1910-11 Manchurian plague outbreak. Read More

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November 2018
1 Read

[The compilation, content and dissemination of ].

Authors:
Y Han

Zhonghua Yi Shi Za Zhi 2018 Jul;48(4):195-203

Institute for the History of Natural Sciences, Chinese Academy of Sciences, Beijing, 100190, China.

()《》 was the 4th medical formulary promulgated by the Song government. Zhou Ying, the medical officer of the Hanlin Academy, was called to compile this book.The content of it mainly came from , compiled by Wang Huaiyin under the order of the Emperor, and the collection of various effective prescriptions. Read More

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July 2018
3 Reads

The Plague of Plagiarism: Prevention and Cure!!!

J Obstet Gynaecol India 2018 Dec 12;68(6):425-431. Epub 2018 Oct 12.

Bombay Hospital and Medical Research Centre, 12 New Marine Line, Mumbai, 400020 India.

Plagiarism is a serious form of scientific misconduct. Literal meaning of the Latin word "to " is "to steal or to kidnap". The act of taking the writings of another person and passing them off as one's own is plagiarism. Read More

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December 2018
7 Reads

Emerging infectious diseases in Africa in the 21st century.

New Microbes New Infect 2018 Nov 21;26:S10-S18. Epub 2018 Sep 21.

IRD, AP-HM, MEPHI, Aix-Marseille Université, IRD, IHU-Méditerranée Infection, Marseille, France.

Many infectious diseases have emerged or reemerged in Africa in the 21st century. Some of them are associated with newly discovered microorganisms such as and others are known, historical diseases such as plague and cholera. In addition are diseases related to previously known microorganisms which recently have been involved for the first time in massive outbreaks with worldwide impacts (such as Ebola virus, Zika virus and Chikungunya virus). Read More

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November 2018
1 Read

Two thousand years of epidemics in Marseille and the Mediterranean Basin.

New Microbes New Infect 2018 Nov 16;26:S4-S9. Epub 2018 Aug 16.

Aix-Marseille Université, IRD, APHM, MEPHI, IHU Méditerranée Infection, Marseille, France.

Marseille has been exposed to epidemics for two millennia, including plague, cholera and yellow fever. This long-standing exposure to epidemics has given the people of Marseilles a particular expertise in fighting epidemics. Lazarets and other quarantine measures were implemented as a response to preventing the further spread of the disease in the community. Read More

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November 2018
6 Reads

Low-density lipoprotein accumulation within the right coronary artery walls for physiological and hypertension conditions.

Biosystems 2018 Nov 1. Epub 2018 Nov 1.

Institute of Physics, University of Silesia, 41-500 Chorzów Katowice, Poland; Silesian Center for Education and Interdisciplinary Research, University of Silesia, 41-500 Chorzów, Poland. Electronic address:

We demonstrate how low-density lipoproteins (LDL) are transported and accumulated through walls of the coronary artery. The result of modeling is a map of the LDL concentration on the patient specific vessel. It identifies places at high risk for plague growth. Read More

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November 2018
1 Read

Silencing of retrotransposon-derived imprinted gene RTL1 is the main cause for postimplantational failures in mammalian cloning.

Proc Natl Acad Sci U S A 2018 Nov 31;115(47):E11071-E11080. Epub 2018 Oct 31.

State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, 100193 Beijing, China;

Substantial rates of fetal loss plague all in vitro procedures involving embryo manipulations, including human-assisted reproduction, and are especially problematic for mammalian cloning where over 90% of reconstructed nuclear transfer embryos are typically lost during pregnancy. However, the epigenetic mechanism of these pregnancy failures has not been well described. Here we performed methylome and transcriptome analyses of pig induced pluripotent stem cells and associated cloned embryos, and revealed that aberrant silencing of imprinted genes, in particular the retrotransposon-derived RTL1 gene, is the principal epigenetic cause of pregnancy failure. Read More

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November 2018
2 Reads

Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani.

ACS Infect Dis 2018 Nov 12. Epub 2018 Nov 12.

The Wellcome Trust Centre for Anti-Infectives Research, School of Life Sciences , University of Dundee , Dow Street , Dundee DD1 5EH , United Kingdom.

Visceral leishmaniasis (VL), caused by the protozoan parasites Leishmania donovani and L. infantum, is responsible for ∼30 000 deaths annually. Available treatments are inadequate, and there is a pressing need for new therapeutics. Read More

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November 2018
9 Reads

Genetic diversity and parasite facilitated establishment of the invasive signal crayfish () in Great Britain.

Ecol Evol 2018 Sep 30;8(18):9181-9191. Epub 2018 Jul 30.

Swansea University Swansea Wales UK.

Successful establishment of non-native species is strongly influenced, among other factors, by the genetic variation of founding populations, which can be enhanced by multiple introductions through admixture. Coexisting pathogens can also facilitate the establishment of non-native species by detrimentally impacting on the native fauna acting as novel weapons. The signal crayfish () is a highly invasive species, which has caused mass declines of native crayfish in Europe through displacement and transmission of the oomycete (crayfish plague), which is typically lethal to native European crayfish. Read More

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September 2018
1 Read

Targeting of the F1 capsular antigen by innate-like B1b cells mediates a rapid protective response against bubonic plague.

NPJ Vaccines 2018 19;3:52. Epub 2018 Oct 19.

1Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, P.O. Box 19, Ness-Ziona, 74100 Israel.

The generation of adaptive immunity by vaccination is usually a prolonged process that requires multiple dosing over several months. Hence, vaccines are administered for disease prevention a relatively long time prior to possible infection as opposed to post-exposure prophylaxis, which typically requires rapid intervention such as antibiotic therapy. The emergence of pathogens resistant to common antibiotic treatments has prompted the search for alternative therapeutic strategies. Read More

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October 2018
5 Reads

Selection Expressions for Procedural Modeling.

IEEE Trans Vis Comput Graph 2018 Oct 23. Epub 2018 Oct 23.

We introduce a new approach for procedural modeling. Our main idea is to select shapes using selection-expressions instead of simple string matching used in current state-of-the-art grammars like CGA shape and CGA++. A selection-expression specifies how to select a potentially complex subset of shapes from a shape hierarchy, e. Read More

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October 2018
1 Read

Construction and functional characterization of a fully human anti-CD19 chimeric antigen receptor (huCAR)-expressing primary human T cells.

J Cell Physiol 2018 Oct 26. Epub 2018 Oct 26.

Department of Medical Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Although remarkable results have been attained by adoptively transferring T cells expressing fully murine and/or humanized anti-CD19 chimeric antigen receptors (CARs) to treat B cell malignancies, evidence of human anti-mouse immune responses against CARs provides a rationale for the development of less immunogenic CARs. By developing a fully human CAR (huCAR), these human anti-mouse immune responses are likely eliminated. This, perhaps, not only increases the persistence of anti-CD19 CAR T cells-thereby reducing the risk of tumor relapse-but also facilitates administration of multiple, temporally separated doses of CAR T cells to the same recipient. Read More

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October 2018
16 Reads
3.840 Impact Factor

Systemic Yersinia pseudotuberculosis as a Cause of Osteomyelitis in a Captive Ring-tailed Lemur (Lemur catta).

J Comp Pathol 2018 Oct 11;164:27-31. Epub 2018 Sep 11.

Royal (Dick) School of Veterinary Studies, The Roslin Institute, University of Edinburgh, Easter Bush, Edinburgh, UK.

Yersinia pseudotuberculosis and Yersinia enterocolitica are ubiquitous pathogens with wildlife and domestic animal reservoirs. Outbreaks of 'non-plague' yersiniosis in man and non-human primates are reported frequently (including zoological specimens and research breeding colonies) and are usually characterized by enteritis, mesenteric lymphadenitis and occasionally organ abscessation. In people, non-septic reactive arthritis is a common sequela to yersiniosis. Read More

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October 2018
1 Read

Ethnopharmacological study of Sephardic remedies in the 19th century: The "Livro de Milizinas".

J Ethnopharmacol 2019 Feb 21;230:20-73. Epub 2018 Oct 21.

Dpto. Ecología e Hidrología, Campus de Espinardo, Universidad de Murcia, 30100 Murcia, Spain. Electronic address:

Ethnopharmacological Relevance: The Sephardic or Judeo-Spanish communities kept a cultural heritage extremely relevant which is recognizable through the peculiar form of their language and practices. Medicine was one of the main professional activities among Jews of Spain before their expulsion in 1492. We expected to find ingredients and recipes in the Sephardic traditional medicine related to classical medicine and to modern ethnopharmacology of Spain, but also influenced by the host countries. Read More

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February 2019
7 Reads

Identification of mosquitoes (Diptera: Culicidae): an external quality assessment of medical entomology laboratories in the MediLabSecure Network.

Parasit Vectors 2018 Oct 23;11(1):553. Epub 2018 Oct 23.

French National Research Institute for Sustainable Development, Research Unit MiVEGEC, IRD-CNRS-Montpellier University, Montpellier, France.

Background: Identification of vectors is of prime importance in the field of medical entomology for both operational and research purposes. An external quality assessment of mosquito identification capacities was carried out within the MediLabSecure Network, which is composed of laboratories located in 19 countries close to the European Union around the Mediterranean and Black seas.

Methods: A set of blind samples consisting of 7 or 8 adult mosquitoes and 4 larvae was given to each participant laboratory. Read More

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October 2018
3 Reads

Recent Advances in the Race to Design a Rapid Diagnostic Test for Antimicrobial Resistance.

ACS Sens 2018 Nov 2;3(11):2202-2217. Epub 2018 Nov 2.

Department of Biotechnology and Food Engineering , Technion - Israel Institute of Technology , Haifa , Israel 3200003.

Even with advances in antibiotic therapies, bacterial infections persistently plague society and have amounted to one of the most prevalent issues in healthcare today. Moreover, the improper and excessive administration of antibiotics has led to resistance of many pathogens to prescribed therapies, rendering such antibiotics ineffective against infections. While the identification and detection of bacteria in a patient's sample is critical for point-of-care diagnostics and in a clinical setting, the consequent determination of the correct antibiotic for a patient-tailored therapy is equally crucial. Read More

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November 2018
6 Reads

A Bacteriophage T4 Nanoparticle-Based Dual Vaccine against Anthrax and Plague.

MBio 2018 Oct 16;9(5). Epub 2018 Oct 16.

Department of Biology, The Catholic University of America, Washington, DC, USA

and , the causative agents of anthrax and plague, respectively, are two of the deadliest pathogenic bacteria that have been used as biological warfare agents. Although Biothrax is a licensed vaccine against anthrax, no Food and Drug Administration-approved vaccine exists for plague. Here, we report the development of a dual anthrax-plague nanoparticle vaccine employing bacteriophage (phage) T4 as a platform. Read More

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October 2018
1 Read

Italian acacia honey exhibits lytic effects against the crayfish pathogens Aphanomyces astaci and Fusarium avenaceum.

Lett Appl Microbiol 2019 Jan 11;68(1):64-72. Epub 2018 Nov 11.

Department of Sciences and Technologies, University of Sannio, Benevento, Italy.

This study purpose was to evaluate the in vitro inhibitory properties of Italian acacia honey extracts against pathogenic aquatic oomycete/fungal isolates that cause different diseases in crayfish, resulting in an elevated mortality rate. The antimycotic activity of acacia honey aqueous extracts was evaluated against the strain UEF88662 of Aphanomyces astaci (oomycete) and the strain SMM2 of Fusarium avenaceum (fungus). The extracts preparation was carried out with water by a cheap, not complex and organic solvent-free procedure, with low environmental impact and the higher possibility of large-scale reproducibility. Read More

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January 2019
1 Read

Insects and the Transmission of Bacterial Agents.

Microbiol Spectr 2018 Oct;6(5)

Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, IHU-Méditerranée Infection, Marseille, France.

Arthropods are small invertebrate animals, among which some species are hematophagous. It is during their blood meal that they can transmit pathogenic microorganisms that they may be harboring to the vertebrate host that they parasitize, which in turn will potentially develop a vector-borne disease. The transmission may occur directly through their bite, but also through contaminated feces. Read More

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October 2018
4 Reads

Ongoing quiescence in the Borborema Plateau Plague focus (Paraiba, Brazil).

An Acad Bras Cienc 2018 Jul-Sep;90(3):3007-3015

Programa de Pós-Graduação em Ciências Biológicas, Centro de Ciências Exatas e da Natureza, Universidade Federal da Paraíba, Cidade Universitária, s/n, Castelo Branco, 58051-900 João Pessoa, PB, Brazil.

Plague is a zoonosis caused by Yersinia pestis, whose cycle is based on a reservoir system composed of mammals and their fleas. Its transmission cycle presents long enzootic periods with undetected cases, sometimes misleading that the cycle is extinct. While surveillance activities in Brazil are being carried out only in some focal areas, the serologic results confirm the persistence of Y. Read More

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December 2017
2 Reads

Twelve tips for clinicians dealing with uncertainty when assessing learners.

Med Teach 2018 Oct 9:1-7. Epub 2018 Oct 9.

a Centre for Health Education Scholarship (CHES), Department of Family Science, Faculty of Medicine , University of British Columbia , Canada.

Clinician educators often experience distress caused by uncertainty regarding how effectively to participate in assessment practices in a way that supports both their programs and their students. Uncertainty is a common state for clinicians, particularly for those who see patients with early or ill-defined illness presentations. While clinicians often feel ill at ease when facing uncertainty in the clinical realm, becoming comfortable with uncertainty and learning to manage such states are now recognized as vital components of clinical practice. Read More

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October 2018
1 Read

Transcriptional Regulation Between the Two Global Regulators RovA and CRP in Yersinia pestis biovar Microtus.

Curr Microbiol 2018 Dec 5;75(12):1634-1641. Epub 2018 Oct 5.

School of Medicine, Jiangsu University, No. 301, Xuefulu, Jingkou, Zhenjiang, 212013, Jiangsu, China.

Yersinia pestis is a dangerous bacterial pathogen that can cause plague. Both RovA and cyclic AMP receptor protein (cAMP-CRP) are required for regulating biofilm- and virulence-related genes in Y. pestis. Read More

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December 2018
1 Read
1.423 Impact Factor

Bone marrow hematopoietic dysfunction in untreated chronic lymphocytic leukemia patients.

Leukemia 2018 Oct 5. Epub 2018 Oct 5.

Department of Immunology, Mayo Clinic, Rochester, MN, 55905, USA.

The consequences of immune dysfunction in B-chronic lymphocytic leukemia (CLL) likely relate to the incidence of serious recurrent infections and second malignancies that plague CLL patients. The well-described immune abnormalities are not able to consistently explain these complications. Here, we report bone marrow (BM) hematopoietic dysfunction in early and late stage untreated CLL patients. Read More

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October 2018
2 Reads

"Farewell to the God of Plague": The Importance of Political Commitment Towards the Elimination of Schistosomiasis.

Trop Med Infect Dis 2018 Oct 3;3(4). Epub 2018 Oct 3.

National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention; Chinese Center for Tropical Diseases Research; WHO Collaborating Centre for Tropical Diseases; National Center for International Research on Tropical Diseases; Key Laboratory of Parasite and Vector Biology, Ministry of Health, Shanghai 200025, China.

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October 2018
6 Reads

Successful transplantation of guinea pig gut microbiota in mice and its effect on pneumonic plague sensitivity.

PeerJ 2018 24;6:e5637. Epub 2018 Sep 24.

State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.

Microbiota-driven variations in the inflammatory response are predicted to regulate host responses to infection. Increasing evidence indicates that the gastrointestinal and respiratory tracts have an intimate relationship with each other. Gut microbiota can influence lung immunity whereby gut-derived injurious factors can reach the lungs and systemic circulation via the intestinal lymphatics. Read More

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September 2018
2 Reads

Local factors associated with on-host flea distributions on prairie dog colonies.

Ecol Evol 2018 Sep 14;8(17):8951-8972. Epub 2018 Aug 14.

U.S. Geological Survey National Wildlife Health Center Madison Wisconsin.

Outbreaks of plague, a flea-vectored bacterial disease, occur periodically in prairie dog populations in the western United States. In order to understand the conditions that are conducive to plague outbreaks and potentially predict spatial and temporal variations in risk, it is important to understand the factors associated with flea abundance and distribution that may lead to plague outbreaks. We collected and identified 20,041 fleas from 6,542 individual prairie dogs of four different species over a 4-year period along a latitudinal gradient from Texas to Montana. Read More

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September 2018
5 Reads

Ail provides multiple mechanisms of serum resistance to Yersinia pestis.

Mol Microbiol 2018 Sep 27. Epub 2018 Sep 27.

Division of Integrated Biomedical Sciences, University of Detroit Mercy School of Dentistry, Detroit, MI, USA.

Ail, a multifunctional outer membrane protein of Yersinia pestis, confers cell binding, Yop delivery and serum resistance activities. Resistance to complement proteins in serum is critical for the survival of Y. pestis during the septicemic stage of plague infections. Read More

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September 2018
24 Reads

Aphanomyces astaci genotypes involved in recent crayfish plague outbreaks in central Italy.

Dis Aquat Organ 2018 Sep;130(3):209-219

Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise 'G. Caporale', 64100 Teramo, Italy.

The oomycete Aphanomyces astaci is the causative agent of crayfish plague in native European freshwater crayfish. Molecular analyses showed that several distinct genotype groups of this pathogen, apparently associated with different original host taxa, are present in Europe. Tracking their distribution may contribute to understanding the introduction pathways of A. Read More

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September 2018
1 Read