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    Improved virtual orbitals in state specific multireference perturbation theory for prototypes of quasidegenerate electronic structure.
    J Chem Phys 2017 Feb;146(6):064111
    Department of Chemistry, Indian Institute of Engineering Science and Technology, Shibpur, Howrah 711103, India.
    The state-specific multireference perturbation theory (SSMRPT) with an improved virtual orbital complete active space configuration interaction (IVO-CASCI) reference function [called as IVO-SSMRPT] is used to investigate the energy surface, geometrical parameters, molecular properties of spectroscopic interest for the systems/situations [such as BeH2, BeCH2, MgCH2, Si2H4, unimolecular dissociation of H2CO, and intramolecular reaction pathways of 1,3-butadiene] where the effect of quasidegeneracy cannot be neglected. The merit of using the IVO-CASCI rather than complete active space self-consistent field (CASSCF) is that it is free from iterations beyond those in the initial SCF calculation and the convergence difficulties that plague CASSCF calculations with increasing size of the CAS. While IVO-CASCI describes the non-dynamical correlation, the SSMRPT scheme is a good second-order perturbative approximation to account for the rest of the correlation energy. Read More

    A phylogenetic transform enhances analysis of compositional microbiota data.
    Elife 2017 Feb 15;6. Epub 2017 Feb 15.
    Program in Computational Biology and Bioinformatics, Duke University, Durham, United States.
    Surveys of microbial communities (microbiota), typically measured as relative abundance of species, have illustrated the importance of these communities in human health and disease. Yet, statistical artifacts commonly plague the analysis of relative abundance data. Here, we introduce the PhILR transform, which incorporates microbial evolutionary models with the isometric log-ratio transform to allow off-the-shelf statistical tools to be safely applied to microbiota surveys. Read More

    Defining the Ail ligand-binding surface: hydrophobic residues in two extracellular loops mediate cell and extracellular matrix binding to facilitate Yop delivery.
    Infect Immun 2017 Feb 6. Epub 2017 Feb 6.
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109
    Yersinia pestis, the causative agent of plague, binds host cells to deliver cytotoxic Yop proteins into the cytoplasm that prevent phagocytosis and generation of pro-inflammatory cytokines. Ail is an eight-stranded β-barrel outer membrane protein with four extracellular loops that mediates cell binding and resistance to human serum. Following deletion of each of the four extracellular loops that potentially interact with host cells, the Ail-Δloop 2 and Ail-Δloop 3 mutants had no cell binding activity while Ail-Δloop 4 maintained cell binding (the Ail-Δloop 1 protein was unstable). Read More

    A Field Study of Plague and Tularemia in Rodents, Western Iran.
    Vector Borne Zoonotic Dis 2017 Feb 6. Epub 2017 Feb 6.
    8 Yersinia Research Unit, National Reference Laboratory, WHO Collaborating Center for Yersinia , Institut Pasteur, Paris, France .
    Introduction: Kurdistan Province in Iran is a historical focus for plague and tularemia. This study aimed at assessing the current status of these two foci by studying their rodent reservoirs.

    Materials And Methods: Rodents were trapped and their ectoparasites were collected. Read More

    A Noise Trimming and Positional Significance of Transposon Insertion System to Identify Essential Genes in Yersinia pestis.
    Sci Rep 2017 Feb 6;7:41923. Epub 2017 Feb 6.
    Biosciences, University of Exeter, Exeter, EX4 4QD, UK.
    Massively parallel sequencing technology coupled with saturation mutagenesis has provided new and global insights into gene functions and roles. At a simplistic level, the frequency of mutations within genes can indicate the degree of essentiality. However, this approach neglects to take account of the positional significance of mutations - the function of a gene is less likely to be disrupted by a mutation close to the distal ends. Read More

    Learning from a cluster randomized controlled trial to improve healthcare workers' access to prevention and care for tuberculosis and HIV in Free State, South Africa: the pivotal role of information systems.
    Glob Health Action 2016 Jan;9(1):30528
    c National Institute for Occupational Health A Division of the National Health Laboratory Service, Johannesburg , South Africa.
    Background Occupational tuberculosis (TB) continues to plague the healthcare workforce in South Africa. A 2-year cluster randomized controlled trial was therefore launched in 27 public hospitals in Free State province, to better understand how a combined workforce and workplace program can improve health of the healthcare workforce. Objective This mid-term evaluation aimed to analyze how well the intervention was being implemented, seek evidence of impact or harm, and draw lessons. Read More

    Successful Treatment of Human Plague with Oral Ciprofloxacin.
    Emerg Infect Dis 2017 Mar;23(3)
    The US Food and Drug Administration recently approved ciprofloxacin for treatment of plague (Yersina pestis infection) based on animal studies. Published evidence of efficacy in humans is sparse. We report 5 cases of culture-confirmed human plague treated successfully with oral ciprofloxacin, including 1 case of pneumonic plague. Read More

    Effectiveness of Fipronil as a Systemic Control Agent Against Xenopsylla cheopis (Siphonaptera: Pulicidae) in Madagascar.
    J Med Entomol 2017 Jan 25. Epub 2017 Jan 25.
    Unité Entomologie Médicale, Institut Pasteur de Madagascar, BP 1274 Ambatofotsikely Antananarivo101, Madagascar
    Fipronil was evaluated as a systemic control agent for the rat flea Xenopsylla cheopis (Rothschild), the main vector of Yersinia pestis (Yersin), the causative agent of plague, in Madagascar. The effectiveness of fipronil as a systemic control agent against X. cheopis was assessed by determining the toxicity values of the "Lethal Dose 50" (LD50). Read More

    Wildlife Plague Surveillance Near the China-Kazakhstan Border: 2012-2015.
    Transbound Emerg Dis 2017 Jan 24. Epub 2017 Jan 24.
    School of Medicine, Shihezi University, Shihezi, China.
    Plague is a zoonotic disease caused by the bacterium Yersinia pestis. This pathogen can be transmitted by fleas and has an enzootic cycle, circulating among small mammals, and occasionally epizootic cycles, infecting other species. In China, infected wild rodents are primarily reservoirs of Y. Read More

    Long-range interactions from the many-pair expansion: A different avenue to dispersion in DFT.
    J Chem Phys 2017 Jan;146(2):024111
    Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, Massachusetts 02139, USA.
    One of the several problems that plague majority of density functional theory calculations is their inability to properly account for long-range correlations giving rise to dispersion forces. The recently proposed many-pair expansion (MPE) [T. Zhu et al. Read More

    Dissociation between working memory performance and proactive interference control in post-traumatic stress disorder.
    Neuropsychologia 2017 Feb 7;96:111-121. Epub 2017 Jan 7.
    VA Northern California Health Care System, Martinez, CA, USA. Electronic address:
    Deficits in working memory (WM) and cognitive control processes have been reported in post-traumatic stress disorder (PTSD), in addition to clinical symptoms such as hypervigilance, re-experiencing, and avoidance of trauma reminders. Given the uncontrollable nature of intrusive memories, an important question is whether PTSD is associated with altered control of interference in WM. Some studies also suggest that episodic memory shows a material-specific dissociation in PTSD, with greater impairments in verbal memory and relative sparing of nonverbal memory. Read More

    Zoonotic pathogens in Atlantic Forest wild rodents in Brazil: Bartonella and Coxiella infections.
    Acta Trop 2017 Apr 8;168:64-73. Epub 2017 Jan 8.
    Laboratório de Hantaviroses e Rickettsioses, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brazil.
    Zoonotic pathogens comprise a significant and increasing fraction of all emerging and re-emerging infectious diseases that plague humans. Identifying host species is one of the keys to controlling emerging infectious diseases. From March 2007 until April 2012, we collected a total of 131 wild rodents in eight municipalities of Rio de Janeiro, Brazil. Read More

    The prevalence of Aphanomyces astaci in invasive signal crayfish from the UK and implications for native crayfish conservation.
    Parasitology 2017 Jan 12:1-8. Epub 2017 Jan 12.
    Centre for Environment,Fisheries and Aquaculture Science (Cefas),The Nothe,Weymouth,Dorset DT4 8UB,UK.
    The crayfish plague agent, Aphanomyces astaci, has spread throughout Europe, causing a significant decline in native European crayfish. The introduction and dissemination of this pathogen is attributed to the spread of invasive North American crayfish, which can act as carriers for A. astaci. Read More

    The Fleas (Siphonaptera) in Iran: Diversity, Host Range, and Medical Importance.
    PLoS Negl Trop Dis 2017 Jan 9;11(1):e0005260. Epub 2017 Jan 9.
    Research Centre for Emerging and Reemerging infectious diseases, Pasteur Institute of Iran, Akanlu, Kabudar Ahang, Hamadan, Iran.
    Background: Flea-borne diseases have a wide distribution in the world. Studies on the identity, abundance, distribution and seasonality of the potential vectors of pathogenic agents (e.g. Read More

    Upconversion Nanocrystals Mediated Lateral-Flow Nanoplatform for in Vitro Detection.
    ACS Appl Mater Interfaces 2017 Feb 19;9(4):3497-3504. Epub 2017 Jan 19.
    Laboratory of Analytical Microbiology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology , Beijing 100071, PR China.
    Upconversion phosphors (UCPs) that are free from interference from biological sample autofluorescence have attracted attention for in vivo and in vitro bioapplications. However, UCPs need to be water-dispersible, nanosized, and highly luminous to realize broad applications. Therefore, the aim of this research is to develop UCPs that meet these comprehensive criteria for in vitro diagnosis. Read More

    Yersinia pestis halotolerance illuminates plague reservoirs.
    Sci Rep 2017 Jan 5;7:40022. Epub 2017 Jan 5.
    Aix Marseille Université, URMITE, UMR 63, CNRS 7278, IRD 198, Inserm 1095, Faculté de Médecine, 27 Bd Jean MOULIN, 13385 Marseille Cedex 5, France.
    The plague agent Yersinia pestis persists for years in the soil. Two millennia after swiping over Europe and North Africa, plague established permanent foci in North Africa but not in neighboring Europe. Mapping human plague foci reported in North Africa for 70 years indicated a significant location at <3 kilometers from the Mediterranean seashore or the edge of salted lakes named chotts. Read More

    Mechanisms of Yersinia YopO kinase substrate specificity.
    Sci Rep 2017 Jan 4;7:39998. Epub 2017 Jan 4.
    Institute of Molecular and Cell Biology, A*STAR (Agency for Science, Technology and Research), Singapore.
    Yersinia bacteria cause a range of human diseases, including yersiniosis, Far East scarlet-like fever and the plague. Yersiniae modulate and evade host immune defences through injection of Yersinia outer proteins (Yops) into phagocytic cells. One of the Yops, YopO (also known as YpkA) obstructs phagocytosis through disrupting actin filament regulation processes - inhibiting polymerization-promoting signaling through sequestration of Rac/Rho family GTPases and by using monomeric actin as bait to recruit and phosphorylate host actin-regulating proteins. Read More

    Astaxanthin improves cognitive performance in mice following mild traumatic brain injury.
    Brain Res 2017 Mar 31;1659:88-95. Epub 2016 Dec 31.
    The Department of Orthopaedic Surgery, Chinese People's Liberation Army General Hospital (301 Hospital), 28 Fuxing Road, Wukesong, Beijing 100000, China. Electronic address:
    Background: Traumatic brain injury (TBI) produces lasting neurological deficits that plague patients and physicians. To date, there is no effective method to combat the source of this problem. Here, we utilized a mild, closed head TBI model to determine the modulatory effects of a natural dietary compound, astaxanthin (AST). Read More

    Tuberculosis in slaughtered cattle and workers in some abattoirs of Baghdad governorate.
    Int J Mycobacteriol 2016 Dec 11;5 Suppl 1:S250-S251. Epub 2016 Nov 11.
    Zonotic Disease Unit College of Veterinary Medicine, Baghdad University, Baghdad, Iraq.
    Objective/background: Tuberculosis (the white plague) is regarded as one of the most widespread infectious diseases and continues to be a leading cause of death and the most prominent public health problem worldwide. It is caused by Mycobacterium tuberculosis complex, which refers to a group of seven species; one of them known as Mycobacterium bovis-the cause of bovine-type tuberculosis-has an exceptionally wide host range. It infects cattle, humans, goats, cats, dogs, buffalo, and deer. Read More

    Factors Associated with Delayed Enrollment in HIV Medical Care among HIV-Positive Individuals in Odessa Region, Ukraine.
    J Int Assoc Provid AIDS Care 2016 Jan 1:2325957416686194. Epub 2016 Jan 1.
    1 Ukrainian Institute on Public Health Policy, Kyiv, Ukraine.
    In Ukraine, about one-third of identified HIV-positive individuals are not connected to care. We conducted a cross-sectional survey (n = 200) among patients registered at Odessa AIDS centers in October to December 2011. Factors associated with delayed enrollment in HIV care (>3 months since positive HIV test) were evaluated using logistic regression. Read More

    The melding of nanomedicine in thrombosis imaging and treatment: a review.
    Future Sci OA 2016 Jun 23;2(2):FSO113. Epub 2016 Mar 23.
    Nanomedicine Group, Lab for Thin Films - Nanosystems & Nanometrology (LTFN), Physics Department, Aristotle University of Thessaloniki, GR-54124, Greece.
    Thromboembolic diseases constitute a plague in our century, wherein an imbalance of hemostasis leads to thrombus formation and vessels constriction reducing blood flow. Hence, the recent rise of nanomedicine gives birth to advanced diagnostic modalities and therapeutic agents for the early diagnosis and treatment of such diseases. Multimodal nanoagents for the detection of intravascular thrombi and nanovehicles for thrombus-targeted fibrinolytic therapy are few paradigms of nanomedicine approaches to overcome current diagnostic treatment roadblocks and persistent clinical needs. Read More

    Brain transcriptomes of harbor seals demonstrate gene expression patterns of animals undergoing a metabolic disease and a viral infection.
    PeerJ 2016 22;4:e2819. Epub 2016 Dec 22.
    Department of Microbiology, Oregon State University , Corvallis , OR , United States.
    Diseases of marine mammals can be difficult to diagnose because of their life history and protected status. Stranded marine mammals have been a particularly useful resource to discover and comprehend the diseases that plague these top predators. Additionally, advancements in high-throughput sequencing (HTS) has contributed to the discovery of novel pathogens in marine mammals. Read More

    Applying the Many-Facet Rasch Measurement Model to Explore Reviewer Ratings of Conference Proposals.
    J Appl Meas 2016;17(3):283-292
    Michael R. Peabody, American Board of Family Medicine, 1648 McGrathiana Pkwy., Lexington, KY 40503, USA,
    For academic conferences, when proposals are submit they are often judged using a rating scale on identified criterion by reviewers who have a shared interest and expertise in the area under consideration. Given the multiple and varied reviewers, an analysis of psychometric properties like rater severity and consistency are important. However, many of the problems that plague the conference proposal selection process are the same issues that plague survey research: rater bias/severity, misuse of rating scale, and the use of raw scores as measures. Read More

    Diminished force production and mitochondrial respiratory deficits are strain-dependent myopathies of subacute limb ischemia.
    J Vasc Surg 2016 Dec 23. Epub 2016 Dec 23.
    Department of Physiology, East Carolina University, Greenville, NC; Diabetes and Obesity Institute, Brody School of Medicine, East Carolina University, Greenville, NC. Electronic address:
    Objective: Reduced skeletal muscle mitochondrial function might be a contributing mechanism to the myopathy and activity based limitations that typically plague patients with peripheral arterial disease (PAD). We hypothesized that mitochondrial dysfunction, myofiber atrophy, and muscle contractile deficits are inherently determined by the genetic background of regenerating ischemic mouse skeletal muscle, similar to how patient genetics affect the distribution of disease severity with clinical PAD.

    Methods: Genetically ischemia protected (C57BL/6) and susceptible (BALB/c) mice underwent either unilateral subacute hind limb ischemia (SLI) or myotoxic injury (cardiotoxin) for 28 days. Read More

    Plague Vaccine Development: Current Research and Future Trends.
    Front Immunol 2016 14;7:602. Epub 2016 Dec 14.
    Microbiology Division, Defence Research & Development Establishment , Gwalior , India.
    Plague is one of the world's most lethal human diseases caused by Yersinia pestis, a Gram-negative bacterium. Despite overwhelming studies for many years worldwide, there is no safe and effective vaccine against this fatal disease. Inhalation of Y. Read More

    Nonviolent civil insecurity is negatively associated with subsequent height-for-age in children aged <5 y born between 1998 and 2014 in rural areas of Africa.
    Am J Clin Nutr 2017 Feb 21;105(2):485-493. Epub 2016 Dec 21.
    Program in Global Health Studies, Allegheny College, Meadville, PA
    Background: Civil wars and wars between states have occurred less frequently since the start of the 21st century, but civil insecurity outside the contexts of official wars continues to plague many parts of the world. The nutritional consequences of civil insecurity may disproportionately affect children, especially if experienced during sensitive developmental periods.

    Objectives: This study estimated the associations between localized nonviolent and violent civil insecurity during key child nutritional periods and subsequent height-for-age z scores (HAZs) in 145,948 children born between 1998 and 2014 in Africa and examined the type of place of residence as a mediating factor. Read More

    Possible links between white plague-like disease, scleractinian corals, and a cryptochirid gall crab.
    Dis Aquat Organ 2016 Dec;122(2):153-161
    Department of Biological Sciences, Florida International University, Miami, FL 33199, USA.
    White plague (WP) is a highly destructive coral disease that rapidly kills susceptible coral species by mass tissue lysis. The pathogen and underlying causes of this disease are not known. In this laboratory-based study, we examined a small coral-associated gall crab from the family Cryptochiridae in terms of a possible association with WP-like lesions. Read More

    From plague to MERS: coordinating Australia's response to emerging infectious diseases.
    Public Health Res Pract 2016 Dec 14;26(5). Epub 2016 Dec 14.
    Office of Health Protection, Australian Government Department of Health, Canberra, ACT.
    Rapid international travel times and the arrival of new and unexpected infectious disease threats have demonstrated that, for effective communicable disease control, Australia's response needs to be flexible and coordinated. This paper summarises how our public health and clinical systems would respond to a case of Middle East respiratory syndrome (MERS) coronavirus and our responsibility under the International Health Regulations to notify the World Health Organization (WHO). It also describes the processes undertaken by WHO when it declares that a disease outbreak is a Public Health Emergency of International Concern. Read More

    New Insights into Autoinducer-2 Signaling as a Virulence Regulator in a Mouse Model of Pneumonic Plague.
    mSphere 2016 Nov-Dec;1(6). Epub 2016 Dec 14.
    Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
    The Enterobacteriaceae family members, including the infamous Yersinia pestis, the causative agent of plague, have a highly conserved interbacterial signaling system that is mediated by the autoinducer-2 (AI-2) quorum-sensing molecule. The AI-2 system is implicated in regulating various bacterial virulence genes in diverse environmental niches. Deletion of the gene encoding the synthetic enzyme for the AI-2 substrate, luxS, leads to either no significant change or, paradoxically, an increase in in vivo bacterial virulence. Read More

    Near-atomic-resolution cryo-EM analysis of the Salmonella T3S injectisome basal body.
    Nature 2016 Dec 14. Epub 2016 Dec 14.
    Department of Biochemistry and Molecular Biology and the Center for Blood Research, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
    The type III secretion (T3S) injectisome is a specialized protein nanomachine that is critical for the pathogenicity of many Gram-negative bacteria, including purveyors of plague, typhoid fever, whooping cough, sexually transmitted infections and major nosocomial infections. This syringe-shaped 3.5-MDa macromolecular assembly spans both bacterial membranes and that of the infected host cell. Read More

    Interfacial gas nanobubbles or oil nanodroplets?
    Phys Chem Chem Phys 2017 Jan;19(2):1108-1114
    Shanghai Synchrotron Radiation Facility, Chinese Academy of Sciences, Shanghai 201204, China. and Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China.
    The existence of nanobubbles at a solid-liquid interface with high stability has been confirmed by myriad experimental studies, and their gaseous nature has also been extensively verified. However, nanodroplets of polydimethylsiloxane (PDMS) recently observed in the atomic force microscopy (AFM) measurement of nanobubbles plague the nanobubble community. It may easily lead to wrong interpretations of the AFM results and thus hinders further application of the already widely used AFM in nanobubble studies. Read More

    The Monomer Electron Density Force Field (MEDFF): A Physically Inspired Model for Noncovalent Interactions.
    J Chem Theory Comput 2017 Jan 9;13(1):161-179. Epub 2016 Dec 9.
    Center for Molecular Modeling (CMM), QCMM Ghent-Brussels Alliance, Ghent University , Technologiepark 903, B9000 Ghent, Belgium.
    We propose a methodology to derive pairwise-additive noncovalent force fields from monomer electron densities without any empirical input. Energy expressions are based on the symmetry-adapted perturbation theory (SAPT) decomposition of interaction energies. This ensures a physically motivated force field featuring an electrostatic, exchange-repulsion, dispersion, and induction contribution, which contains two types of parameters. Read More

    The Yersinia Type III secretion effector YopM Is an E3 ubiquitin ligase that induced necrotic cell death by targeting NLRP3.
    Cell Death Dis 2016 Dec 8;7(12):e2519. Epub 2016 Dec 8.
    State key Laboratory of Pathogen and Biosecurity, Beijing Institute of Biotechnology, Beijing, China.
    Yersinia pestis uses type III effector proteins to target eukaryotic signaling systems. The Yersinia outer protein (Yop) M effector from the Y. pestis strain is a critical virulence determinant; however, its role in Y. Read More

    Plenty Is No Plague: Streptomyces Symbiosis with Crops.
    Trends Plant Sci 2017 Jan 1;22(1):30-37. Epub 2016 Dec 1.
    Laboratoire de Recherche en Sciences Végétales, Université de Toulouse, CNRS, UPS, 24 Chemin de Borde Rouge, Auzeville, BP42617, 31326 Castanet Tolosan, France.
    Streptomyces spp. constitute a major clade of the phylum Actinobacteria. These Gram-positive, filamentous prokaryotes are ubiquitous in soils and marine sediments, and are commonly found in the rhizosphere or inside plant roots. Read More

    The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation.
    PLoS Pathog 2016 Dec 2;12(12):e1006035. Epub 2016 Dec 2.
    UMass Medical School, Program in Innate Immunity, Division of Infectious Diseases and Immunology, Department of Medicine, Worcester, Massachusetts, United States of America.
    Type III secretion systems (T3SS) are central virulence factors for many pathogenic Gram-negative bacteria, and secreted T3SS effectors can block key aspects of host cell signaling. To counter this, innate immune responses can also sense some T3SS components to initiate anti-bacterial mechanisms. The Yersinia pestis T3SS is particularly effective and sophisticated in manipulating the production of pro-inflammatory cytokines IL-1β and IL-18, which are typically processed into their mature forms by active caspase-1 following inflammasome formation. Read More

    Prospects for Biological Soilborne Disease Control: Application of Indigenous Versus Synthetic Microbiomes.
    Phytopathology 2017 Mar 27;107(3):256-263. Epub 2017 Jan 27.
    First author: U.S. Department of Agriculture-Agricultural Research Service, Physiology and Pathology of Tree Fruits Research Laboratory, 1104 N. Western Avenue, Wenatchee, WA 98801; and second author: Agricultural Research Organization of Israel, Volcani Center, Bet Dagan, Israel.
    Biological disease control of soilborne plant diseases has traditionally employed the biopesticide approach whereby single strains or strain mixtures are introduced into production systems through inundative/inoculative release. The approach has significant barriers that have long been recognized, including a generally limited spectrum of target pathogens for any given biocontrol agent and inadequate colonization of the host rhizosphere, which can plague progress in the utilization of this resource in commercial field-based crop production systems. Thus, although potential exists, this model has continued to lag in its application. Read More

    Secondary metabolites of endophytic Xylaria species with potential applications in medicine and agriculture.
    World J Microbiol Biotechnol 2017 Jan 28;33(1):15. Epub 2016 Nov 28.
    Instituto de Química, Departamento de Productos Naturales, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, 4510, Delegación Coyoacán, Mexico, Mexico.
    Fungal endophytes are important sources of bioactive secondary metabolites. The genus Xylaria Hill (ex Schrank, 1789, Xylariaceae) comprises various endophytic species associated to both vascular and non vascular plants. The secondary metabolites produced by Xylaria species include a variety of volatile and non-volatile compounds. Read More

    Vaccination via Chloroplast Genetics: Affordable Protein Drugs for the Prevention and Treatment of Inherited or Infectious Human Diseases.
    Annu Rev Genet 2016 Nov 21;50:595-618. Epub 2016 Oct 21.
    Department of Biochemistry, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104; email:
    Plastid-made biopharmaceuticals treat major metabolic or genetic disorders, including Alzheimer's, diabetes, hypertension, hemophilia, and retinopathy. Booster vaccines made in chloroplasts prevent global infectious diseases, such as tuberculosis, malaria, cholera, and polio, and biological threats, such as anthrax and plague. Recent advances in this field include commercial-scale production of human therapeutic proteins in FDA-approved cGMP facilities, development of tags to deliver protein drugs to targeted human cells or tissues, methods to deliver precise doses, and long-term stability of protein drugs at ambient temperature, maintaining their efficacy. Read More

    Enhanced control of cortical pyramidal neurons with micro-magnetic stimulation.
    IEEE Trans Neural Syst Rehabil Eng 2016 Nov 22. Epub 2016 Nov 22.
    Magnetic stimulation is less sensitive to the inflammatory reactions that plague conventional electrode-based cortical implants and therefore may be useful as a next-generation (implanted) cortical prosthetic. The fields arising from micro-coils are quite small however and thus, their ability to modulate cortical activity must first be established. Here, we show that layer V pyramidal neurons (PNs) can be strongly activated by micro-coil stimulation and further, the asymmetric fields arising from such coils do not simultaneously activate horizontally -oriented axon fibers, thus confining activation to a focal region around the coil. Read More

    Vaccine-Preventable Diseases In Pediatric Patients: A Review Of Measles, Mumps, Rubella, And Varicella.
    Pediatr Emerg Med Pract 2016 Dec 2;13(12):1-20. Epub 2016 Dec 2.
    Clinical Associate Professor of Emergency Medicine and Pediatrics, New York University School of Medicine, Bellevue Hospital Center, New York, NY.
    Vaccine-preventable diseases such as measles, mumps, rubella, and varicella continue to plague children and adults worldwide. Although public health programs have helped decrease the prevalence and sequelae of these diseases, outbreaks still occur. To limit the spread of these diseases, emergency clinicians must be able to readily identify the characteristic presentations of the rashes associated with measles, rubella, and varicella, as well as the common presenting features associated with mumps. Read More

    Host transcriptomic responses to pneumonic plague reveal that Yersinia pestis inhibits both the initial adaptive and innate immune responses in mice.
    Int J Med Microbiol 2017 Jan 14;307(1):64-74. Epub 2016 Nov 14.
    State Key laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China. Electronic address:
    Pneumonic plague is the most deadly form of infection caused by Yersinia pestis and can progress extremely fast. However, our understanding on the host transcriptomic response to pneumonic plague is insufficient. Here, we used RNA-sequencing technology to analyze transcriptomic responses in mice infected with fully virulent strain 201 or EV76, a live attenuated vaccine strain lacking the pigmentation locus. Read More

    On the Mechanics of Transcatheter Aortic Valve Replacement.
    Ann Biomed Eng 2017 Feb 21;45(2):310-331. Epub 2016 Nov 21.
    Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA.
    Transcatheter aortic valves (TAVs) represent the latest advances in prosthetic heart valve technology. TAVs are truly transformational as they bring the benefit of heart valve replacement to patients that would otherwise not be operated on. Nevertheless, like any new device technology, the high expectations are dampened with growing concerns arising from frequent complications that develop in patients, indicating that the technology is far from being mature. Read More

    Investigation of and Response to 2 Plague Cases, Yosemite National Park, California, USA, 2015.
    Emerg Infect Dis 2016 Dec;22(12)
    In August 2015, plague was diagnosed for 2 persons who had visited Yosemite National Park in California, USA. One case was septicemic and the other bubonic. Subsequent environmental investigation identified probable locations of exposure for each patient and evidence of epizootic plague in other areas of the park. Read More

    Innovative solutions in bariatric surgery.
    Gland Surg 2016 Oct;5(5):529-536
    1 Department of General and Endocrinological Surgery, Medical University of Bialystok, Bialystok, Poland.
    Nowadays all over the world the rising plague of obesity can be observed. The obesity was recognized as "an epidemic of XXI century" in 1997 by World Health Organization. The change of eating habits, active lifestyle or pharmacological curation are often insufficient to fight against obesity. Read More

    Recent advances in obesity: the role of turmeric tuber and its metabolites in the prophylaxis and therapeutical strategies.
    Curr Med Chem 2016 Nov 17. Epub 2016 Nov 17.
    Medical University of Lublin - Department of Pharmacognosy with Medicinal Plants Unit, Lublin, Poland.
    This contribution reviews current literature on the application of turmeric tuber - a commonly used spice - as an anti-obesity agent. Following an introduction about the biochemical significance of obesity and characteristics of various groups of natural products applied in the therapy of overweight patients, the authors focus on Curcuma secondary metabolites, their pharmacological applications and present a detailed study on the regulatory properties of turmeric towards various biochemical mechanisms of obesity. These important findings help to fight the 21st century plague, which is an excessive weight gain, connected with the development of the metabolic syndrome and implying cardiovascular problems and diabetes, which, in consequence, lead to a significant shortening of the life span. Read More

    Biomaterials and Nanotherapeutics for Enhancing Skin Wound Healing.
    Front Bioeng Biotechnol 2016 31;4:82. Epub 2016 Oct 31.
    Department of Biomedical Engineering, University of Texas at Austin, Austin, TX, USA; Institute for Biomaterials, Drug Delivery and Regenerative Medicine, University of Texas at Austin, Austin, TX, USA; Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX, USA; Institute for Computational Engineering and Sciences, University of Texas at Austin, Austin, TX, USA.
    Wound healing is an intricate process that requires complex coordination between many cell types and an appropriate extracellular microenvironment. Chronic wounds often suffer from high protease activity, persistent infection, excess inflammation, and hypoxia. While there has been intense investigation to find new methods to improve cutaneous wound care, the management of chronic wounds, burns, and skin wound infection remain challenging clinical problems. Read More

    Modeling of spatio-temporal variation in plague incidence in Madagascar from 1980 to 2007.
    Spat Spatiotemporal Epidemiol 2016 Nov 18;19:125-135. Epub 2016 Oct 18.
    Institute of Infection and Global Health, Department of Epidemiology and Population Health, University of Liverpool, Leahurst Campus, Neston, Cheshire, UK; Health Protection Research Unit for Emerging and Zoonotic Infections, University of Liverpool, UK.
    Plague is an infectious disease caused by the bacterium Yersinia pestis, which, during the fourteenth century, caused the deaths of an estimated 75-200 million people in Europe. Plague epidemics still occur in Africa, Asia and South America. Madagascar is today one of the most endemic countries, reporting nearly one third of the human cases worldwide from 2004 to 2009. Read More

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