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Acta Trop 2022 Jun 22:106570. Epub 2022 Jun 22.

National Reference Laboratory for Plague, Tularemia and Q fever, Research Centre for Emerging and Reemerging infectious diseases, Pasteur Institute of Iran, Akanlu, Kabudar Ahang, Hamadan, Iran; Department of Epidemiology and Biostatistics, Research Centre for Emerging and Reemerging infectious diseases, Pasteur Institute of Iran, Tehran, Iran. Electronic address:

Background: Tularemia is a zoonotic disease that has been reported in many countries of the Northern Hemisphere. However, in some countries, such as Iran, this disease has been neglected by the health care system, and it is under-reported.

Case Presentation: Here we report an unusual case of ulceroglandular tularemia occurring in a 35-year-old woman who presented with a skin lesion of the left flank, inguinal lymphadenopathy, and an abdominal abscess. Read More

Viruses 2022 May 25;14(6). Epub 2022 May 25.

Saint Petersburg Pasteur Institute, Federal Service on Consumer Rights Protection and Human Well-Being Surveillance, 197101 Saint Petersburg, Russia.

The Bunyamwera serological group includes a number of geographically widespread viruses that are related but not identical and have serological cross-reactivity. As the first group members were obtained in the pre-sequencing era, their classifications (group attribution, species differentiation) were originally based on serological reactions. At the same time, the accuracy of the typing in each case depended on the variety of viruses that the researcher had as a comparison panel. Read More

Pathogens 2022 Jun 1;11(6). Epub 2022 Jun 1.

National Centre for Disciplinary Research in Animal Health and Innocuity (CENID-SAI), Laboratory of Helminthology, National Institute for Research in Forestry, Agriculture and Livestock, INIFAP-SADER, Morelos 62550, Mexico.

Soil-borne parasitic nematodes cause severe deterioration in the health of crops and supply animals, leading to enormous economic losses in the agriculture and livestock industry worldwide. The traditional strategy to control these parasites has been based on chemically synthesised compounds with parasiticidal activity, e.g. Read More

Science 2022 Jun 23;376(6600):1376. Epub 2022 Jun 23.

J Clin Ethics 2022 ;33(2):81-91

Professor of Psychiatry and Director of Programs in Medical Ethics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, Maryland 20814 USA.

This article focuses on three different ways that we may demean people by seeing them as less than they are, and describes ways we may best avoid doing this. More specifically, I explain how we may not see the physical and emotional issues that plague patients and others. This may be because they choose not to disclose their difficulties to us. Read More

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2022 May;34(5):454-458

Department of Encephalopathy, First Affiliated Hospital of Hebei University of Chinese Medicine, Shijiazhuang 050011, Hebei, China. Corresponding author: Mei Jianqiang, Email:

Objective: To analyze the rules of medication and principles of formulas for the treatment of coronavirus disease 2019 (COVID-19) using the traditional Chinese medicine inheritance support platform (V2.5).

Methods: The clinical data, including gender, age, clinical symptoms, frequency of traditional Chinese medicine medication and prescription information, of patients with COVID-19 and asymptomatic infection who were admitted to Hebei COVID-19 designated hospital supported by medical team of First Affiliated Hospital of Hebei University of Chinese Medicine from January to March 2021 were collected. Read More

Acta Trop 2022 Jun 17:106566. Epub 2022 Jun 17.

Pest Management Centre, Sokoine University of Agriculture, Morogoro.

Background: Rodents are known to be reservoirs of plague bacteria, Yesinia pestis in the sylvatic cycle. A preliminary investigation of the suspected plague outbreak was conducted in Madunga Ward, Babati District Council in Manyara Region December-2019-January 2020 Following reported two cases which were clinically suspected as showing plague disease symptoms.

Method: The commensal and field rodents were live trapped using Sherman traps in Madunga Ward, where plague suspect cases were reported and, in the Nou-forest reserve areas at Madunga Ward, Babati District Council, to assess plague risk in the area. Read More

Front Immunol 2022 26;13:846155. Epub 2022 May 26.

Division of Infectious Diseases, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, United States.

Acute malnutrition, or wasting, is implicated in over half of all deaths in children under five and increases risk of infectious disease. Studies in humans and preclinical models have demonstrated that malnutrition is linked to an immature intestinal microbiota characterized by increased prevalence of Enterobacteriaceae. Observational studies in children with moderate acute malnutrition (MAM) have also observed heightened systemic inflammation and increased circulating bacterial lipopolysaccharides (LPS; endotoxin). Read More

R Soc Open Sci 2022 Jun 15;9(6):211888. Epub 2022 Jun 15.

Littoral, Environnement et Sociétés, UMR 7266 CNRS - La Rochelle Université, La Rochelle, France.

Mitochondrial DNA (mtDNA) translocated into the nuclear genome (numt), when co-analysed with genuine mtDNA, could plague phylogeographic studies. To evaluate numt-related biases in population genetics parameters in birds, which are prone to accumulating numts, we targeted the mitochondrial gene. We looked at 13 populations of Audubon's shearwater (), including five mitochondrial lineages. Read More

Parasit Vectors 2022 Jun 17;15(1):214. Epub 2022 Jun 17.

Department of Emergency Response and Plague Control, Xinjiang Center for Disease Control and Prevention, Urumqi, China.

Background: The Junggar Basin plague focus was the most recently identified natural plague focus in China. Through extensive field investigations, great gerbils (Rhombomys opimus) have been confirmed as the main host in this focus, and the community structure of their parasitic fleas is associated with the intensity of plague epizootics. The aim of this study is to provide an indicator that can be surveyed to evaluate the risk of plague epizootics. Read More

J Hist Med Allied Sci 2022 Jun 14. Epub 2022 Jun 14.

Yale University, Connecticut, United States.

The human immunodeficiency virus (HIV) has devastated the United States for forty years. Though there are highly effective treatments for HIV and acquired immune deficiency syndrome (AIDS) today, the early years of the HIV/AIDS epidemic in New York City (NYC) were filled with uncertainty, fear, and death-not unlike the period we are now experiencing in the COVID-19 era. Existing scholarship captures the political discourse of the HIV/AIDS era and the narratives of physicians who specialized in HIV medicine. Read More

Science 2022 06 16;376(6599):1254-1255. Epub 2022 Jun 16.

Graves in Kyrgyzstan hold early victims of plague that swept medieval Europe. Read More

MMWR Morb Mortal Wkly Rep 2022 06 17;71(24):806-807. Epub 2022 Jun 17.

J Vector Borne Dis 2022 Jan-Mar;59(1):12-21

ICMR-Vector Control Research Centre Field Station, Madurai, Tamil Nadu, India.

Fleas (Insecta, Siphonaptera) are important vectors of plague and murine typhus in many parts of the world. Currently, about 2700 flea species were described in the world. The most common vector flea Xenopsylla cheopis is found throughout India, but X. Read More

Infect Chemother 2022 May 30. Epub 2022 May 30.

Department of Plastic Surgery, Inha University College of Medicine, Incheon, Korea.

Nature 2022 Jun;606(7915):635-636

Nature 2022 Jun 15;606(7915):718-724. Epub 2022 Jun 15.

Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.

The origin of the medieval Black Death pandemic (AD 1346-1353) has been a topic of continuous investigation because of the pandemic's extensive demographic impact and long-lasting consequences. Until now, the most debated archaeological evidence potentially associated with the pandemic's initiation derives from cemeteries located near Lake Issyk-Kul of modern-day Kyrgyzstan. These sites are thought to have housed victims of a fourteenth-century epidemic as tombstone inscriptions directly dated to 1338-1339 state 'pestilence' as the cause of death for the buried individuals. Read More

Sci Rep 2022 Jun 14;12(1):9863. Epub 2022 Jun 14.

Department of Biomedical Data Science, Stanford University, Stanford, USA.

The unmapped readspace of whole genome sequencing data tends to be large but is often ignored. We posit that it contains valuable signals of both human infection and contamination. Using unmapped and poorly aligned reads from whole genome sequences (WGS) of over 1000 families and nearly 5000 individuals, we present insights into common viral, bacterial, and computational contamination that plague whole genome sequencing studies. Read More

Int J Disaster Risk Reduct 2022 Jul 3;77:103093. Epub 2022 Jun 3.

Department of Biostatistics, School of Public Health, Sabzevar University of Medical Sciences, Iran.

The Covid-19 epidemic is known as "the deadliest plague of the century" that has overshadowed various aspects of human life. Despite mutations in SARS-CoV-2, the development of new strains, and the escape of immunity, preventive health behaviors continue to play a key role in controlling this epidemic. The purpose of this study was to determine the relationship between risk perception and the performance of preventive behaviors of people in the Covid-19 peak period in society. Read More

Front Public Health 2022 26;10:910872. Epub 2022 May 26.

State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.

Introduction: The Qinghai-Tibet Plateau is considered the most plague-heavy region in China, and skinning and eating marmots () are understood to be the main exposure factors to plague. is relatively inactive during marmots' hibernation period. However, this case report shows plague infection risk is not reduced but rather increased during the marmot hibernation period if plague exposure is not brought under control. Read More

N Engl J Med 2022 06 11;386(24):2257-2259. Epub 2022 Jun 11.

From New York University, New York.

Hist Cienc Saude Manguinhos 2022 Apr-Jun;29(2):381-398

Assistant professor, Departamento de Ciencias Históricas y Geográficas/Universidad de Tarapacá.Arica - Región de Arica y Parinacota - Chile

The coronavirus pandemic has exposed a global tendency throughout history to blame immigrants for propagating epidemics. Chinese individuals were thus targeted during past public health crises in Peru, but during the current coronavirus pandemic racist notions painting people of Chinese descent as "agents of contagion" diminished significantly. Here we examine three major epidemics (yellow fever, the bubonic plague, and covid-19) to demonstrate the current and somewhat surprising shift in negative attitudes toward the Chinese community. Read More

Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med 2022 May;30(3):517-523

The Federal State Autonomous Educational Institution of Higher Education "The Belgorod State National Research University" of the Minobrnauka of Russia, 308015, Belgorod, Russia.

The plague pandemic ("The Black Death") that struck Eurasia in the middle of XIV century, "settled" this lethal disease in Europe for a long time. The new outbreaks of this disease, with breaks of several years, occurred in single cities, regions and states, covering sometimes entire continent over the next centuries. However, impression that "The Black Death" made upon minds of European scribes, staggering European society by its inevitability, for a long time determined particular angle of view under which it is accepted to consider the history of plague in Europe in the epoch of Middle Ages and early New Age. Read More

Conserv Physiol 2022 31;10(1):coac031. Epub 2022 May 31.

Division for Marine and Environmental Research, Rudjer Boskovic Institute, 10002 Zagreb, Croatia.

Crayfish are keystone species important for maintaining healthy freshwater ecosystems. Crayfish species native to Europe, such as and , are facing decline and are increasingly endangered by changing climate and invasions of non-native crayfish, such as and . The success of these invasions largely depends on differences in ontogeny between the native species and the invaders and how changes in the environment will affect the ontogeny. Read More

Curr Opin Infect Dis 2022 06;35(3):188-195

Department of Animal, Veterinary and Food Sciences, University of Idaho, Moscow, Idaho, USA.

Purpose Of Review: Pathogenic Yersinia have been a productive model system for studying bacterial pathogenesis. Hallmark contributions of Yersinia research to medical microbiology are legion and include: (i) the first identification of the role of plasmids in virulence, (ii) the important mechanism of iron acquisition from the host, (iii) the first identification of bacterial surface proteins required for host cell invasion, (iv) the archetypical type III secretion system, and (v) elucidation of the role of genomic reduction in the evolutionary trajectory from a fairly innocuous pathogen to a highly virulent species.

Recent Findings: The outer membrane (OM) protein Ail (attachment invasion locus) was identified over 30 years ago as an invasin-like protein. Read More

Cureus 2022 May 1;14(5):e24654. Epub 2022 May 1.

Emergency Medicine and Internal Medicine, Allegheny Health Network, Pittsburgh, USA.

The ST-segment elevation is commonly associated with acute myocardial Infarction. However, there are other non-ischemic causes of ST-elevation. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly contagious illness that continues to plague the world since the first case was reported in China over two years ago. Read More

J Am Chem Soc 2022 Jun 2;144(23):10119-10132. Epub 2022 Jun 2.

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.

Secondary Li-ion batteries have enabled a world of portable electronics and electrification of personal and commercial transportation. However, the charge storage capacity of conventional intercalation cathodes is reaching the theoretical limit set by the stoichiometry of Li in the fully lithiated structure. Increasing the Li:transition metal ratio and consequently involving structural anions in the charge compensation, a mechanism termed anion redox, is a viable method to improve storage capacities. Read More

J Am Soc Mass Spectrom 2022 Jun 1. Epub 2022 Jun 1.

Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510080, China.

Electrospray ionization mass spectrometry (ESI-MS) is widely used in drug development, therapeutic drug monitoring, and other fields. However, unstable mass spectral signals, especially during the initial stages of instrument operation, plague analysts. Generally, in quantitative experiments, the stability of response can be achieved by running the analytical system for some time. Read More

Curr Opin Organ Transplant 2022 06;27(3):204-210

Division of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania.

Purpose Of Review: Significant limitations in organ availability and postoperative graft dysfunction plague lung transplantation and there is continual need for innovation. Ex-vivo lung perfusion (EVLP) has emerged over the last decade as an alternative and/or complementary allograft storage and assessment tool, however logistical hurdles have limited its widespread dissemination. As such, the overall current and potential value of EVLP on modern-day lung transplantation should be considered as innovation moves forward. Read More

Sci Transl Med 2022 Jun 1;14(647):eabg1787. Epub 2022 Jun 1.

GlaxoSmithKline Pharmaceuticals, Collegeville, PA, USA.

Gepotidacin is a first-in-class triazaacenaphthylene antibacterial agent that selectively inhibits bacterial DNA gyrase and topoisomerase IV through a unique binding mode and has the potential to treat a number of bacterial diseases. Development of this new agent to treat pneumonic plague caused by depends on the U.S. Read More