91,678 results match your criteria Placenta Previa


Expression of Plet1 controls interstitial migration of murine small intestinal dendritic cells.

Eur J Immunol 2018 Dec 7. Epub 2018 Dec 7.

Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands.

Under homeostatic conditions, dendritic cells (DCs) continuously patrol the intestinal lamina propria. Upon antigen encounter, DCs initiate C-C motif chemokine receptor 7 (CCR7) expression and migrate into lymph nodes to direct T cell activation and differentiation. The mechanistic underpinnings of DC migration from the tissues to lymph nodes have been largely elucidated, contributing greatly to our understanding of DC functionality and intestinal immunity. Read More

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December 2018

Quantitative Proteomics by SWATH-MS Suggest an Association Between Circulating Exosomes and Maternal Metabolic Changes in Gestational Diabetes Mellitus.

Proteomics 2018 Dec 7:e1800164. Epub 2018 Dec 7.

Exosome Biology Laboratory, Centre for Clinical Diagnostics, University of Queensland Centre for Clinical Research, Royal Brisbane and Women's Hospital, The University of Queensland, Brisbane, QLD, 4029, Australia.

Several factors including placental hormones (PH) released from the human placenta have been associated with the development of insulin resistance and gestational diabetes mellitus (GDM). However, circulating levels of PH do not correlate well with maternal insulin sensitivity across gestation, suggesting that other, previously unrecognized, mechanisms may be involved. The levels of circulating exosomes are higher in GDM compared to normal. Read More

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December 2018
3.807 Impact Factor

Silencing H19 regulated proliferation, invasion, and autophagy in the placenta by targeting miR-18a-5p.

J Cell Biochem 2018 Dec 9. Epub 2018 Dec 9.

Department of Obstetrics and Gynecology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.

Fetal growth restriction (FGR) is a serious pregnancy complication associated with increased perinatal mortality and morbidity. It may lead to neurodevelopmental impairment and adulthood onset disorders. Recently, long noncoding RNAs (lncRNAs) were found to be associated with the pathogenesis of FGR. Read More

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December 2018

microRNA-96 protects pancreatic β-cell function by targeting PAK1 in gestational diabetes mellitus.

Biofactors 2018 Nov 8;44(6):539-547. Epub 2018 Dec 8.

Department of Obstetrics and Gynaecology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.

Gestational diabetes mellitus (GDM) is a disease condition in which a woman develops high blood sugar levels during pregnancy, which might be induced by multiple factors. Among those relative factors, microRNA (miRNA) is well-known to be involved in GDM development. In this study, we investigated the role of miRNA in GDM by analyzing miRNA expression profiling in placenta tissues from healthy or GDM pregnancies. Read More

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November 2018

Refractory Severe Thrombocytopenia during Pregnancy: How to Manage.

Rev Bras Ginecol Obstet 2018 Dec 7;40(12):803-807. Epub 2018 Dec 7.

Department of Anaesthesiology, Centro Hospitalar Lisboa Norte, Lisboa, Portugal.

Thrombocytopenia is the most common hemostatic change in pregnancy, but severe thrombocytopenia is rare. One of the causes, immune thrombocytopenic purpura (ITP), is characterized by increased platelet destruction by immunoglobulin G (IgG) antibodies, presenting a high risk of hemorrhage for the patient, but also for the fetus, since antibodies may cross the placenta. We present the case of a 23-year-old pregnant woman with a history of Langerhans cell histiocytosis of the mandible submitted to surgery and chemotherapy when she was 10 years old, with diagnosis of ITP since then. Read More

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December 2018

A potential role for GSK3beta in glucose-driven intrauterine catch-up growth in maternal obesity.

Endocrinology 2018 Dec 10. Epub 2018 Dec 10.

Department of Paediatrics and Adolescent Medicine, University Hospital of Cologne, Cologne, Germany.

Obesity and an unhealthy nutrition are on the rise and affect also women in childbearing age and hence, during pregnancy. Despite normal or even high birth weight the offspring suffers from long term metabolic risks. We hypothesized that fetal growth is disturbed during different intrauterine phases. Read More

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December 2018

Cross-Species Immune Recognition Between Plasmodium vivax Duffy Binding Protein Antibodies and the Plasmodium falciparum Surface Antigen VAR2CSA.

J Infect Dis 2019 Jan;219(1):110-120

School of Public Health, University of Alberta, Edmonton, Canada.

Background: In pregnancy, Plasmodium falciparum parasites express the surface antigen VAR2CSA, which mediates adherence of red blood cells to chondroitin sulfate A (CSA) in the placenta. VAR2CSA antibodies are generally acquired during infection in pregnancy and are associated with protection from placental malaria. We observed previously that men and children in Colombia also had antibodies to VAR2CSA, but the origin of these antibodies was unknown. Read More

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January 2019

Genome Sequences of Zika Virus Strains Recovered from Amniotic Fluid, Placenta, and Fetal Brain of a Microcephaly Patient in Thailand, 2017.

Microbiol Resour Announc 2018 Sep 20;7(11). Epub 2018 Sep 20.

Department of Biomedical Informatics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.

We present here the complete genome sequences of Zika virus strains isolated from aborted fetal tissue (brain and placenta) and amniotic fluid of a microcephaly patient in Thailand in 2017. The virus genomes that were sequenced have an average length of 10,807 nucleotides. Read More

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September 2018

Metformin and insulin treatment prevent placental telomere attrition in boys exposed to maternal diabetes.

PLoS One 2018 11;13(12):e0208533. Epub 2018 Dec 11.

Division of Biomedicine, Cardiff School of Biosciences, Cardiff University, Cardiff, Wales, United Kingdom.

Shortened leukocyte and placental telomeres associated with gestational diabetes mellitus (GDM) suggest this exposure triggers telomere attrition contributing to adverse outcomes. We applied high resolution Single Telomere Length Analysis (STELA) to placenta from GDM pregnancies with different treatment pathways to determine their effectiveness at preventing telomere attrition. Differences in telomere length between control (N = 69), GDM lifestyle intervention (n = 14) and GDM treated with metformin and/or insulin (n = 17) was tested by Analysis of Covariance (ANCOVA) followed by group comparisons using Fisher's least significant difference. Read More

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December 2018

Efavirenz pharmacokinetics during pregnancy and infant washout.

Antivir Ther 2018 Dec 10. Epub 2018 Dec 10.

Departments of Pharmacy and Pharmacology and Toxicology, Radboud University Medical Center, Nijmegen, The Netherlands.

Background: Limited data exist on efavirenz pharmacokinetics in HIV-positive pregnant women and neonatal washout.

Methods: HIV-infected pregnant women receiving 600 mg efavirenz once daily had intensive steady-state 24-hour pharmacokinetics profiles during the second trimester (2T), third trimester (3T) and 6-12 weeks postpartum (PP). Maternal and umbilical cord blood samples were drawn at delivery and neonatal washout pharmacokinetics were determined. Read More

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December 2018

Transgenerational hypocortisolism and behavioral disruption are induced by the antidepressant fluoxetine in male zebrafish .

Proc Natl Acad Sci U S A 2018 Dec 10. Epub 2018 Dec 10.

Department of Biology, University of Ottawa, Ottawa, ON K1N 6N5, Canada;

The global prevalence of depression is high during childbearing. Due to the associated risks to the mother and baby, the selective serotonin reuptake inhibitor fluoxetine (FLX) is often the first line of treatment. Given that FLX readily crosses the placenta, a fetus may be susceptible to the disruptive effects of FLX during this highly plastic stage of development. Read More

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December 2018

Metabolomics for predicting fetal growth restriction: protocol for a systematic review and meta-analysis.

BMJ Open 2018 Dec 6;8(12):e022743. Epub 2018 Dec 6.

Department of Gynaecology and Obstetrics, University Campinas, Sao Paulo, Brazil.

Introduction: Fetal growth restriction (FGR) is a relevant research and clinical concern since it is related to higher risks of adverse outcomes at any period of life. Current predictive tools in pregnancy (clinical factors, ultrasound scan, placenta-related biomarkers) fail to identify the true growth-restricted fetus. However, technologies based on metabolomics have generated interesting findings and seem promising. Read More

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December 2018

Reference genes for accurate normalization of gene expression in wood-decomposing fungi.

Fungal Genet Biol 2018 Dec 5. Epub 2018 Dec 5.

Department of Plant and Microbial Biology, University of Minnesota, Saint Paul, MN. Electronic address:

Wood-decomposing fungi efficiently decompose plant lignocellulose, and there is increasing interest in characterizing and perhaps harnessing the fungal gene regulation strategies that enable wood decomposition. Proper interpretation of these fungal mechanisms relies on accurate quantification of gene expression, demanding reliable internal control genes (ICGs) as references. Commonly used ICGs such as actin, however, fluctuate among wood-decomposing fungi under defined conditions. Read More

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December 2018

Classification of fetal resilience to porcine reproductive and respiratory syndrome (PRRS) based on temporal viral load in late gestation maternal tissues and fetuses.

Virus Res 2018 Dec 5. Epub 2018 Dec 5.

Western College of Veterinary Medicine, University of Saskatchewan, S7N 5B4, Canada. Electronic address:

Although porcine reproductive and respiratory syndrome virus (PRRSV) readily crosses the maternal fetal interface (MFI) in third trimester, fetal resilience varies within litters. The aim of this study was to characterize PRRSV-2 concentration in MFI and fetuses at five time points after experimental inoculation of late gestation gilts and use this information to classify potentially resistant, resilient and susceptible fetuses. The secondary objective was to verify the relationship between PRRS viral load and intrauterine growth retardation (IUGR). Read More

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December 2018

High density placental mesenchymal stromal cells provide neuronal preservation and improve motor function following in utero treatment of ovine myelomeningocele.

J Pediatr Surg 2018 Oct 4. Epub 2018 Oct 4.

Department of Surgery, University of California Davis, Sacramento, CA, USA.

Purpose: The purpose of this study was to determine whether seeding density of placental mesenchymal stromal cells (PMSCs) on extracellular matrix (ECM) during in utero repair of myelomeningocele (MMC) affects motor function and neuronal preservation in the ovine model.

Methods: MMC defects were surgically created in 33 fetuses and repaired following randomization into four treatment groups: ECM only (n = 10), PMSC-ECM (42 K cells/cm) (n = 8), PMSC-ECM (167 K cells/cm) (n = 7), or PMSC-ECM (250-300 K cells/cm) (n = 8). Motor function was evaluated using the Sheep Locomotor Rating Scale (SLR). Read More

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October 2018
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Folate and choline absorption and uptake: Their role in fetal development.

Biochimie 2018 Dec 6. Epub 2018 Dec 6.

Institute of Human Nutrition and Dietetics, Poznań University of Life Sciences.

Scope: In this review, we attempt to assess how choline and folate transporters affect fetal development. We focus on how the expression of these transporters in response to choline and folate intake affects transport effectiveness. We additionally describe allelic variants of the genes encoding these transporters and their phenotypic effects. Read More

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December 2018

Aspirin pre-treatment modulates ozone-induced fetal growth restriction and alterations in uterine blood flow in rats.

Reprod Toxicol 2018 Dec 5. Epub 2018 Dec 5.

Environmental Public Health Division, National Health & Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA.

Prenatal exposure to ozone has been linked to low birth weight in people and fetal growth restriction in rats. Clinical recommendations suggest use of low dose aspirin to lower risk of preeclampsia and intrauterine growth restriction in high-risk pregnancies, yet its utility in mitigating the postnatal effects of gestational ozone exposure is unknown. The present study investigated the possibility of low dose aspirin to mitigate the effects of ozone exposure during pregnancy. Read More

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December 2018

Reduced methylation downregulates CD39/ENTPD1 and ZDHHC14 to suppress trophoblast cell proliferation and invasion: Implications in preeclampsia.

Pregnancy Hypertens 2018 Oct 24;14:59-67. Epub 2018 Mar 24.

Obstetrics Department, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China. Electronic address:

Preeclampsia (PE) is a pregnancy-specific syndrome affecting up to 8% of pregnancies worldwide. While PE is a leading cause of maternal and neonatal mortality and morbidity, the pathophysiology of PE is unclear to date. Here, we have verified that dysregulation of CD39/ectonucleoside triphosphate diphosphohydrolase-1 (ENTPD1) and zinc finger DHHC-type containing 14 (ZDHHC14) via DNA methylation plays a vital role in late-onset PE pathology. Read More

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October 2018

Hydrogen peroxide-mediated oxidative stress induces inflammasome activation in term human placental explants.

Pregnancy Hypertens 2018 Oct 27;14:29-36. Epub 2018 Jul 27.

Department of Gynaecology and Obstetrics, Medical School, Botucatu Sao Paulo State University (Unesp), 18618-970 Sao Paulo, Brazil.

Background: The placenta is a multifunctional organ that can suffer with imbalances between pro- and antioxidant molecules, contributing for inflammatory imbalance. The inflammation generated by oxidative stress may induce inflammasome activation, an essential complex for pro-inflammatory cytokine production.

Objective: The aim of this study was to evaluate whether hydrogen peroxide (HO) mediated oxidative stress induces inflammasome activation on placental explants. Read More

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October 2018

Aspirin use during pregnancy and hypoxia-related placental pathology.

Pregnancy Hypertens 2018 Oct 30;14:177-188. Epub 2018 Jul 30.

Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:

Objective: Aspirin has been shown to prevent preeclampsia. But the mechanisms remain unclear despite that improved placental circulation is considered as an underlying contributor. Our aim was to examine the hypoxia-related morphological and histopathological placental measures in relation to aspirin use during pregnancy. Read More

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October 2018

EGFL7 gene expression is regulated by hypoxia in trophoblast and altered in the plasma of patients with early preeclampsia.

Pregnancy Hypertens 2018 Oct 5;14:115-120. Epub 2018 Sep 5.

Translational Obstetrics Group, Department of Obstetrics and Gynaecology, University of Melbourne, Mercy Hospital for Women, 163 Studley Road, Heidelberg 3084, Victoria, Australia. Electronic address:

Introduction: Preeclampsia is a severe complication of pregnancy, and likely arises from abnormal placental development in early pregnancy. Persistent placental hypoxia is thought to trigger the release of anti-angiogenic factors into the maternal circulation leading to widespread endothelial dysfunction. Epidermal growth factor-like domain 7 (EGFL7) is a secreted angiogenic factor that may play a key role in the disrupted angiogenesis seen in response to placental hypoxia that characterizes preeclampsia. Read More

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October 2018

[The MRI analysis of 220 cases of placenta previa complicated with placenta accrete or not].

Zhonghua Yi Xue Za Zhi 2018 Dec;98(45):3692-3696

Department of Radiology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China.

To investigate the diagnostic value of MRI for placenta previa complicated with placenta accreta or not. A total of 220 placenta previa patients were diagnosed by prenatal ultrasound and MRI in The Second Affiliated Hospital of Wenzhou Medical University from May 2014 to May 2017.The MRI images of 220 placenta previa patients suspicious of placenta previa were interpreted by two radiologists who majored on gynecological radiology. Read More

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December 2018

Down-Regulation of Laminin (LN)- α5 is Associated with Preeclampsia and Impairs Trophoblast Cell Viability and Invasiveness Through PI3K Signaling Pathway.

Cell Physiol Biochem 2018 6;51(5):2030-2040. Epub 2018 Dec 6.

Department of Obstetrics, The First Affiliated Hospital, Chongqing Medical University, Chongqing,

Background/aims: Preeclampsia (PE) is a gestational disorder defined as hypertension and proteinuria, which is deemed a major cause of maternal and neonatal mortality and morbidity worldwide. The aim of this study was to investigate the expression patterns of placental laminin (LN)-α5 expression in normal and PE pregnancies, as well as evaluating the effects of LN-α5 on trophoblast proliferation, apoptosis, and invasion.

Methods: LN-α5 expression levels were examined by reverse-transcriptase polymerase chain reaction (RT-PCR), and further confirmed by western blotting and immunofluorescence staining. Read More

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December 2018
2 Reads

Evidence for functional interactions between the placenta and brain in pregnant mice.

FASEB J 2018 Dec 6:fj201802037R. Epub 2018 Dec 6.

Division of Animal Sciences, University of Missouri, Columbia, Missouri, USA.

The placenta plays a pivotal role in the development of the fetal brain and also influences maternal brain function, but our understanding of communication between the placenta and brain remains limited. Using a gene expression and network analysis approach, we provide evidence that the placenta transcriptome is tightly interconnected with the maternal brain and fetal brain in d 15 pregnant C57BL/6J mice. Activation of serotonergic synapse signaling and inhibition of neurotrophin signaling were identified as potential mediators of crosstalk between the placenta and maternal brain and fetal brain, respectively. Read More

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December 2018
2 Reads

Vascular changes in fetal growth restriction: clinical relevance and future therapeutics.

J Perinatol 2018 Dec 5. Epub 2018 Dec 5.

Anatomical Pathology, ACT Pathology, The Canberra Hospital and the Australian National University Medical School, College of Health and Medicine, Canberra, ACT, Australia.

Fetal growth restriction (FGR) affects about 5-10% pregnancies and is associated with poorer outcomes in the perinatal period. Additionally, long standing epidemiological data support its association with chronic diseases such as hypertension and diabetes. Cardiac and vascular adaptations in response to chronic hypoxemia due to utero-placental insufficiency are hallmarks of fetal adaptations. Read More

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December 2018
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Laterally-positioned placenta in placenta previa.

J Matern Fetal Neonatal Med 2018 Dec 5:1-161. Epub 2018 Dec 5.

a Department of Obstetrics and Gynecology , Jichi Medical University , Shimotsuke , Tochigi , Japan.

Objectives: To clarify perinatal outcomes of patients with placenta previa (PP) with the placenta mainly positioned in the lateral uterine wall (lateral PP), thereby clinically characterizing this condition.

Study Design: The retrospective cohort study was performed involving patients with lateral PP between January 2006 and December 2016. The placental position was determined and classified by magnetic resonance imaging. Read More

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December 2018
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Transfer of Deoxynivalenol (DON) through Placenta, Colostrum and Milk from Sows to Their Offspring during Late Gestation and Lactation.

Toxins (Basel) 2018 Dec 4;10(12). Epub 2018 Dec 4.

Department of Production Animal Clinical Sciences, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, P.O. Box 369 Sentrum, 0102 Oslo, Norway.

Deoxynivalenol (DON) contamination of feed may result in reduced growth, feed refusal, immunosuppression, and health problems in swine. Piglets can be exposed to DON via placenta before birth and via milk during lactation. The extent of early-life exposure of piglets to DON is, however, not fully known. Read More

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December 2018
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Effects of Arachidonic and Docosohexahenoic Acid Supplementation during Gestation in Rats. Implication of Placental Oxidative Stress.

Int J Mol Sci 2018 Dec 4;19(12). Epub 2018 Dec 4.

Department of Physiology, Faculty of Medicine, University Autónoma of Madrid, 28029 Madrid, Spain.

Arachidonic and docosahexaenoic acids (ARA and DHA) are important during pregnancy. However, the effects of dietary supplementation on fetal growth and oxidative stress are inconclusive. We aimed to assess the effect of high ARA and DHA diet during rat gestation on: (1) ARA and DHA availability in plasma and placenta, (2) fetal growth, and (3) placental oxidative stress, analyzing the influence of sex. Read More

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December 2018

Mineral homeostasis in murine fetuses is sensitive to maternal calcitriol, but not to absence of fetal calcitriol.

J Bone Miner Res 2018 Dec 3. Epub 2018 Dec 3.

Faculty of Medicine - Endocrinology, Memorial University of Newfoundland, St. John's, NL, Canada.

Vitamin D receptor (VDR) null fetuses have normal serum minerals, PTH, skeletal morphology and mineralization, but increased serum calcitriol, placental calcium transport, and placental expression of Pthrp, Trpv6, and (as reported in this study) Pdia3. We examined Cyp27b1 null fetal mice, which do not make calcitriol, to determine if loss of calcitriol has the same consequences as loss of VDR. Cyp27b1 null and WT females were mated to Cyp27b1 males, which generated Cyp27b1 null and Cyp27b1 fetuses from Cyp27b1 null mothers, and Cyp27b1 and WT fetuses from WT mothers. Read More

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December 2018
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Association of Long-term Child Growth and Developmental Outcomes With Metformin vs Insulin Treatment for Gestational Diabetes.

JAMA Pediatr 2018 Dec 3. Epub 2018 Dec 3.

Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill.

Importance: Metformin is an emerging option for treating gestational diabetes (GDM). However, because metformin crosses the placenta, patients and clinicians are concerned with its long-term effect on child health.

Objective: To estimate the association of treating GDM with metformin vs insulin with child growth and development. Read More

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December 2018

Application of iTRAQ proteomics in identification of the differentially expressed proteins of placenta of pregnancy with preeclampsia.

J Cell Biochem 2018 Dec 3. Epub 2018 Dec 3.

Department of Obstetrics and Gynecology, Wuxi Matemal and Child Health Hospital Affiliated to Nanjing Medical University, Wuxi, China.

Objective: To explore the differential protein profile of preeclampsia and identify its potential biomarker.

Methods: Around 20 pregnant women with preeclampsia (preeclampsia group) and 20 normal-term pregnancy (normal group) were collected from 2017 to 2018 in the study. Total protein of placenta tissues was extracted, denaturized, deoxidized, and enzymolyzed. Read More

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December 2018

Characterization of metalloproteases and serine proteases of Toxoplasma gondii tachyzoites and their effect on epithelial cells.

Parasitol Res 2018 Dec 1. Epub 2018 Dec 1.

Departamento de Bioquímica, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), Av. IPN No. 2508, Col. Zacatenco, C.P. 07360, Ciudad de México, Mexico.

Toxoplasma gondii can infect all nucleated cells from warm-blooded organisms. After infection, Toxoplasma spreads throughout the body and migrates across biological barriers, such as the intestinal and blood-brain barriers, as well as the placenta in pregnant women. The mechanisms for parasite dissemination are still unknown; however, proteases could play a role as a virulence factor. Read More

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December 2018

Aneuploidy Screening using Next Generation Sequencing.

Methods Mol Biol 2019 ;1885:85-102

IGENOMIX USA, Torrance, CA, USA.

Chromosomal aneuploidy is recognized to be a significant contributing factor in implantation failure and spontaneous miscarriage Hellani et al. (Reprod Biomed Online 17:841-847, 2008), Vanneste et al. (Nat Med 15:577-583, 2009) and is likely to be responsible for the majority of IVF failure [Baltaci et al. Read More

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January 2019

Placental MAOA expression mediates prenatal stress effects on temperament in 12-month-olds.

Infant Child Dev 2018 Jul-Aug;27(4). Epub 2018 Apr 16.

Clinical Psychology Program, The Graduate Center (CUNY), New York, New York, USA.

The placenta adapts to maternal environment and its alterations may have a lasting impact on child's temperament development. Prenatal stress has been linked to both a downregulation of monoamine oxidase A (MAOA) gene expression in the placenta and to difficult temperament. Capitalizing on an ongoing longitudinal study, we analysed data from 95 mother-child dyads to investigate whether MAOA mediates the association between prenatal stress and infant temperament. Read More

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Zika virus infection in human placental tissue explants is enhanced in the presence of dengue virus antibodies in-vitro.

Emerg Microbes Infect 2018 Dec 1;7(1):198. Epub 2018 Dec 1.

Institute of Virology, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany.

The current Zika virus (ZIKV) outbreak is associated with neurological malformations and disorders in neonates. Areas of increased incidence of malformations may overlap with dengue-hyperendemic areas. ZIKV infection is enhanced by antibodies against dengue virus (DENV) in cell culture and inbred mice. Read More

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December 2018

Placental thickness on ultrasound and neonatal birthweight.

J Perinat Med 2018 Dec 3. Epub 2018 Dec 3.

Penn State Hershey Medical Center, Division of Maternal Fetal Medicine, Hershey, PA, USA.

Objective To investigate the relationship between maximal placental thickness during routine anatomy scan and birthweight at delivery. Methods This retrospective descriptive study analyzed 200 term, singleton deliveries in 2016 at Penn State Hershey Medical Center. We measured maximal placental thickness in the sagittal plane from the ultrasound images of the placenta obtained at the 18-21-week fetal anatomy screen. Read More

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December 2018

Portal hypertension: The desperate search for the placenta.

Curr Res Transl Med 2018 Nov 29. Epub 2018 Nov 29.

Department of Surgery. School of Medicine, Complutense University of Madrid, 28040 Madrid, Spain.

We propose that the circulatory impairments produced, in both portal hypertension and liver cirrhosis, to a certain degree resemble those characterizing prenatal life in the fetus. In fact, the left-right circulatory syndrome is common in cirrhotic patients and in the fetus. Thus, in patients with portal hypertension and chronic liver failure, the re-expression of a blood circulation comparable to fetal circulation is associated with the development of similar amniotic functions, i. Read More

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November 2018

Expression of Toll-like receptors 2, 4 and 6 in the equine chorioallantois.

Vet Immunol Immunopathol 2018 Dec 16;206:49-53. Epub 2018 Nov 16.

Institute of Veterinary Pathology, Faculty of Veterinary Medicine, Leipzig University, An den Tierkliniken 33, 04103, Leipzig, Germany.

In mares, placental diseases are a common cause of pregnancy failure and they can have an economic impact on the horse breeding industry. To our knowledge no published data on TLR expression in the equine placenta exist. This study examined the expression of TLR 2, 4 and 6 as transcript and protein in the placenta (chorioallantois) of 14 foals born alive. Read More

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December 2018

Effects of selective serotonin-reuptake inhibitors (SSRIs) in JEG-3 and HIPEC cell models of the extravillous trophoblast.

Placenta 2018 Dec 30;72-73:62-73. Epub 2018 Oct 30.

INRS-Institut Armand-Frappier, 531 boulevard des Prairies, Laval, QC, H7V 1B7, Canada. Electronic address:

Introduction: Between 2 and 10% of pregnant women are treated with selective serotonin-reuptake inhibitors (SSRIs) for depression. The extravillous trophoblasts (evTBs), which migrate and invade maternal tissues, are crucial for embryo implantation and remodeling of maternal spiral arteries. Poor migration/invasion of evTBs can cause serious pregnancy complications, yet the effects of SSRIs on these processes has never been studied. Read More

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December 2018
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Placental inflammation by HMGB1 activation of TLR4 at the syncytium.

Placenta 2018 Dec 2;72-73:53-61. Epub 2018 Nov 2.

Centre of Molecular Inflammation Research (CEMIR), Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), NO-7491, Trondheim, Norway. Electronic address:

Introduction: Normal pregnancy is characterized by an elevated inflammatory state involving the placenta. The placental inflammation is further increased in preeclampsia, resulting in release of harmful danger signals to the maternal circulation. Activation of toll-like receptors (TLR)2 and TLR4 by endogenous danger signals plays a role in inflammatory diseases. Read More

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December 2018
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Comparative expression patterns of selected membrane transporters in differentiated BeWo and human primary trophoblast cells.

Placenta 2018 Dec 29;72-73:48-52. Epub 2018 Oct 29.

Institute of Biochemistry and Molecular Medicine, University of Bern, Switzerland; Swiss National Centre of Competence in Research, NCCR TransCure, University of Bern, Switzerland. Electronic address:

Although placental membrane transporters have an important impact on materno-fetal nutrient transfer, placental cell models are poorly characterized regarding transporter expression. We assessed the mRNA expression of 26 physiologically important solute carriers and ABC transporters in BeWo (b30 clone) and primary human trophoblast cells (PHT) before and after syncytialization. 77% of the transporters showed similar mRNA expression changes between BeWo and PHT after syncytialization. Read More

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December 2018
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Estimation of the burden of human placental micro- and nano-vesicles extruded into the maternal blood from 8 to 12 weeks of gestation.

Placenta 2018 Dec 30;72-73:41-47. Epub 2018 Oct 30.

The Hospital of Obstetrics & Gynaecology, Fudan University, China; Department of Obstetrics & Gynaecology, The University of Auckland, New Zealand. Electronic address:

Background: The human placenta extrudes a variety of extracellular vesicles (EVs) into the maternal blood daily. These vesicles may be crucial to the adaptation of the maternal cardiovascular and immune systems to pregnancy. Quantifying the EVs that are released in early gestation is important to our understanding of how placental EVs may contribute to the regulation of maternal physiology. Read More

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December 2018

Progressive uterine artery occlusion in the Guinea pig leads to defects in placental structure that relate to fetal growth.

Placenta 2018 Dec 17;72-73:36-40. Epub 2018 Oct 17.

Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, Downing Street, University of Cambridge, Cambridge, CB2 3EG, UK. Electronic address:

Intrauterine growth restriction (IUGR) is a common obstetric complication with immediate and life-long consequences for offspring health. Yet the mechanisms underlying its aetiology require elucidation. Recent work in the guinea pig shows that progressive uterine artery occlusion induced IUGR and vascular dysfunction in pups. Read More

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December 2018
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Distinct communication patterns of trophoblastic miRNA among the maternal-placental-fetal compartments.

Placenta 2018 Dec 22;72-73:28-35. Epub 2018 Oct 22.

Magee-Womens Research Institute, USA; Department of Obstetrics and Gynecology and Reproductive Science, University of Pittsburgh, Pittsburgh, PA, 15213, USA; Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, 15213, USA. Electronic address:

Introduction: The placenta produces microRNAs (miRNA) that may traffic to the maternal or fetal compartments and influence the physiology of pregnancy. The trafficking patterns of miRNA expressed from the large human chromosome 19 and chromosome 14 clusters (C19MC and C14MC), remains unclear. We interrogated the cross-sectional landscape of miRNA expression within the human placenta, fetal and maternal plasma to elucidate miRNA trafficking. Read More

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December 2018
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Polymer size affects biodistribution and placental accumulation of the drug delivery biopolymer elastin-like polypeptide in a rodent pregnancy model.

Placenta 2018 Dec 20;72-73:20-27. Epub 2018 Oct 20.

Department of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, MS, USA; Department of Neurology, University of Mississippi Medical Center, Jackson, MS, USA. Electronic address:

Introduction: Fusion of therapeutic agents to Elastin-like Polypeptide (ELP) is a novel drug delivery strategy for prevention of placental drug transfer. Previous studies have used a 60 kDa ELP tag for this purpose. However, placental transfer of ELP may be size dependent. Read More

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December 2018

Human cytomegalovirus utilises cellular dual-specificity tyrosine phosphorylation-regulated kinases during placental replication.

Placenta 2018 Dec 13;72-73:10-19. Epub 2018 Oct 13.

Serology and Virology Division, SEALS Microbiology, Prince of Wales Hospital, Sydney, Australia; School of Women's and Children's Health, University of New South Wales, Australia; School of Medical Sciences, University of New South Wales, Australia; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia. Electronic address:

Introduction: Congenital cytomegalovirus (HCMV) infection may cause significant fetal malformation and in severe cases fetal and neonatal death. Fetal injury may be caused indirectly by the placental response to infection. Dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs) have recently been identified as critical kinases for HCMV replication. Read More

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December 2018

Real-time microscopic assessment of fatty acid uptake kinetics in the human term placenta.

Placenta 2018 Dec 31;72-73:1-9. Epub 2018 Jul 31.

School of Medicine, Oregon Health and Science University, Portland, OR, 97239, USA; Center for Developmental Health, Knight Cardiovascular Institute Oregon Health and Science University, Portland, OR, 97239, USA; Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR, 97239, USA; Department of Medicine, Oregon Health and Science University, Portland, OR, 97239, USA. Electronic address:

Introduction: The placenta employs an efficient and selective fatty acid transport system to supply lipids for fetal development. Disruptions in placental fatty acid transport lead to restricted fetal growth along with cardiovascular and neurologic deficits. Nevertheless, little is known about the molecular mechanisms involved in human placental fatty acid trafficking during the initial steps of uptake, or the importance of fatty acid chain length in determining uptake rates. Read More

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December 2018

Adipose tissue exosomal proteomic profile reveals a role on placenta glucose metabolism in gestational diabetes mellitus.

J Clin Endocrinol Metab 2018 Dec 3. Epub 2018 Dec 3.

Exosome Biology Laboratory, Centre for Clinical Diagnostics, University of Queensland Centre for Clinical Research, Royal Brisbane and Women's Hospital, The University of Queensland, Brisbane QLD, Australia.

Context: Molecules produced by adipose tissue (AT) function as an endocrine link between maternal AT and fetal growth by regulating placental function in normal and gestational diabetes mellitus (GDM).

Objective: We hypothesised that AT-derived exosomes from women with GDM carry a specific set of proteins that influences glucose metabolism in placenta.

Design: Exosomes were isolated from omental AT-conditioned media from pregnant women with normal glucose tolerance (exo-NGT, n=65) and women with GDM (exo-GDM, n=82). Read More

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December 2018
6.209 Impact Factor

Unraveling the Mysteries of the Human Placenta.

Authors:
Rita Rubin

JAMA 2018 Dec 5. Epub 2018 Dec 5.

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December 2018

Mechanisms Underpinning Adaptations in Placental Calcium Transport in Normal Mice and Those With Fetal Growth Restriction.

Front Endocrinol (Lausanne) 2018 20;9:671. Epub 2018 Nov 20.

Maternal and Fetal Health Research Centre, Division of Developmental Biology and Medicine, Faculty of Biology, Medicine and Health, School of Medical Sciences, University of Manchester, Manchester, United Kingdom.

Fetal delivery of calcium, via the placenta, is crucial for appropriate skeletal mineralization. We have previously demonstrated that maternofetal calcium transport, per gram placenta, is increased in the placental specific insulin-like growth factor 2 knockout mouse (P0) model of fetal growth restriction (FGR) compared to wild type littermates (WTL). This effect was mirrored in wild-type (WT) mice comparing lightest vs. Read More

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November 2018
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