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J Gynecol Obstet Hum Reprod 2021 May 10:102161. Epub 2021 May 10.

Department of Obstetrics and Gynecology, Jewish General Hospital, McGill University, Montreal, Quebec, Canada; Center for Clinical Epidemiology and Community Studies, Jewish General Hospital, Montreal, Quebec, Canada. Electronic address:

Objectives: Although urolithiasis is relatively common in the general population, there is limited information on this condition available in the pregnant population. The objectives of this study are to identify the incidence of urolithiasis in pregnancy, as well as to compare maternal and fetal outcomes associated with urolithiasis in pregnancy.

Methods: Using the Healthcare Cost and Utilization Project-Nationwide Inpatient Sample database from the United States, a population-based retrospective cohort study consisting of pregnant women who delivered between 1999 and 2015 was conducted. Read More

Biol Reprod 2021 May 12. Epub 2021 May 12.

Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of America.

The obstetrical conditions placenta accreta spectrum (PAS) and placenta previa are a significant source of pregnancy-associated morbidity and mortality, yet the specific molecular and cellular underpinnings of these conditions are not known. In this study, we identified misregulated gene expression patterns in tissues from placenta previa and percreta (the most extreme form of PAS) compared with control cases. By comparing this gene set with existing placental single-cell and bulk RNA-Seq datasets, we show that the upregulated genes predominantly mark extravillous trophoblasts. Read More

Asian J Surg 2021 May 4. Epub 2021 May 4.

Inner Mongolia Medical University, Department of Orthopedics, Affiliated Hospital of Inner Mongolia Medical University, Hohhot North Street, Inner Mongolia 010050, China.

Nurs Open 2021 May 7. Epub 2021 May 7.

Department of Obstetrics, Affiliated Hospital of Qingdao University, Qingdao, China.

Aim: To identify a set of scientific, systematic and clinically applicable nursing-sensitive quality indicators for pernicious placenta previa (PPP).

Design: A modified Delphi-Consensus Technique.

Methods: According to literature retrieval published between 2009-2019, 38 nursing-sensitive quality indicators were chosen and a questionnaire was designed. Read More

J Perinat Med 2021 May 3. Epub 2021 May 3.

Gynecology and Obstetrics Unit, Prenatal Diagnosis Ultrasound Center, Sant'Anna Hospital, Città della Salute e della Scienza, University of Turin, Turin, Italy.

Objectives: Evaluate ultrasound diagnostic accuracy, maternal-fetal characteristics and outcomes in case of vasa previa diagnosed antenatally, postnatally or with spontaneous resolution before delivery.

Methods: Monocentric retrospective study enrolling women with antenatal or postnatal diagnosis of vasa previa at Sant'Anna Hospital in Turin from 2007 to 2018. Vasa previa were defined as fetal vessels that lay 2 cm within the uterine internal os using 2D and Color Doppler transvaginal ultrasound. Read More

Cureus 2021 Mar 29;13(3):e14171. Epub 2021 Mar 29.

Department of Obstetrics and Gynaecology, Lady Hardinge Medical College, Delhi, IND.

Background Peripartum hysterectomy (PRH) is the surgical removal of the uterus performed in obstetrical complications such as uncontrolled postpartum haemorrhage (PPH), unrepairable uterine rupture, and sepsis. Its incidence has increased in recent years. The objective of this study was to review all the cases of PRH in a tertiary care teaching hospital over three years (January 2017-December 2019) to determine its incidence and analyse clinico-demographic characteristics in these women. Read More

BMC Anesthesiol 2021 Apr 29;21(1):134. Epub 2021 Apr 29.

Department of Anesthesiology, Peking University People's Hospital, Beijing, 100044, China.

Background: Pernicious placenta previa (PPP) can increase the risk of perioperative complications. During caesarean section in patients with adherent placenta, intraoperative blood loss, hysterectomy rate and transfusion could be reduced by interventional methods. Our study aimed to investigate the influence of maternal hemodynamics control and neonatal outcomes of prophylactic temporary abdominal aortic balloon (PTAAB) occlusion for patients with pernicious placenta previa. Read More

Medicina (Kaunas) 2021 Apr 2;57(4). Epub 2021 Apr 2.

Department of Obstetrics and Gynaecology, Vilnius University Hospital Santaros Klinikos, Santariskiu st. 2, 08661 Vilnius, Lithuania.

: Placenta previa and placenta accreta spectrum are considered major causes of massive postpartum hemorrhage. Objective: To determine whether the placement of an occlusion balloon catheter in the internal iliac artery could reduce bleeding and other related complications during cesarean delivery in patients with placenta previa and placenta accreta spectrum. : A retrospective analysis was conducted at two tertiary obstetric units of Lithuania. Read More

BMC Pregnancy Childbirth 2021 Apr 26;21(1):332. Epub 2021 Apr 26.

Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China.

Background: Although maternal deaths are rare in developed regions, the morbidity associated with severe postpartum hemorrhage (SPPH) remains a major problem. To determine the prevalence and risk factors of SPPH, we analyzed data of women who gave birth in Guangzhou Medical Centre for Critical Pregnant Women, which received a large quantity of critically ill obstetric patients who were transferred from other hospitals in Southern China.

Methods: In this study, we conducted a retrospective case-control study to determine the prevalence and risk factors for SPPH among a cohort of women who gave birth after 28 weeks of gestation between January 2015 and August 2019. Read More

Am J Obstet Gynecol MFM 2021 Apr 22:100384. Epub 2021 Apr 22.

Department of Urology, Stanford University, Stanford, CA.

Objective: To examine the association of preconception paternal health and risk of adverse maternal outcomes among healthy mothers.

Study Design: Retrospective analysis of live births from 2009-2016 among healthy women 20-45 years of age in the IBM Marketscan® research database. Infants were linked to paired mothers and fathers using family ID. Read More

Am J Obstet Gynecol 2021 Apr 21. Epub 2021 Apr 21.

Dartmouth-Hitchcock Medical Center, Lebanon, NH.

Background: Contemporary embryo biopsy in the United States involves removal of several cells from a blastocyst that would become the placenta for preimplantation genetic testing (PGT). Embryos are then cryopreserved while patients await biopsy results, with transfers occurring in a subsequent cycle as a single frozen-thawed embryo transfer, if euploid.

Objective: We sought to determine if removal of these cells for PGT was associated with adverse obstetrical or neonatal outcomes following frozen-thawed single embryo transfer. Read More

Am J Obstet Gynecol 2021 Apr 21. Epub 2021 Apr 21.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA, USA; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA. Electronic address:

Background: Although an infrequent occurrence, the placenta can adhere abnormally to the gravid uterus leading to significantly high maternal morbidity and mortality during cesarean section (CS). Contemporary national statistics related to a morbidly adherent placenta, referred to as placenta accreta spectrum (PAS), are needed.

Objective: To examine national trends, characteristics, and perioperative outcomes of women who underwent CS for PAS in the United States. Read More

Eur J Radiol Open 2021 2;8:100344. Epub 2021 Apr 2.

Department of Obstetrics and Gynecology, Gunma University Hospital, Gunma, Japan.

Purpose: To determine the effect of ovarian arteries on the use of prophylactic abdominal aortic balloon occlusion (PABO) in patients with coexisting placenta accreta and placenta previa.

Methods: Thirty-two pregnant women with coexisting placenta accreta and placenta previa treated with PABO in our hospital during 2013-2020 were retrospectively analyzed. The patients were divided into two groups: one with infra-renal abdominal aortic balloon occlusion above the ovarian artery (Group A, n = 15) and the other with occlusion below the ovarian artery (Group B, n = 17). Read More

Womens Health Issues 2021 Apr 19. Epub 2021 Apr 19.

The Lurie Institute for Disability Policy, Heller School for Social Policy and Management, Brandeis University, Waltham, Massachusetts, 02453.

Background: Although the literature suggests that women with disabilities are at increased risk for pregnancy complications and adverse birth outcomes, there are few population-based studies of the pregnancy outcomes among deaf and hard of hearing (DHH) women in the United States.

Objective: To compare pregnancy complications and neonatal outcomes between deliveries to DHH and non-DHH women using national hospitalization discharge record data.

Study Design: We used the 2007-2016 Healthcare Cost and Utilization Project National Inpatient Sample to compare pregnancy complications and outcomes among deliveries to DHH women with deliveries to non-DHH women using bivariate and Poisson regressions, controlling for sociodemographic, hospital, and clinical characteristics. Read More

Am J Perinatol 2021 Apr 20. Epub 2021 Apr 20.

Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, Massachusetts.

Objective:  The aim of the study is to determine the relationship between a hospital's provision of subspecialty neonatal and maternal care. Specifically, we sought to understand where women with high-risk maternal conditions received intrapartum care and estimate the potential transfer burden for those with maternal high-risk conditions delivering at hospitals without subspecialty maternal care.

Study Design:  This is a descriptive study using data from 2015 State Inpatient Databases and the American Hospital Association Annual Survey. Read More

Curr Med Sci 2021 Apr 20;41(2):336-341. Epub 2021 Apr 20.

Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

Placenta accreta spectrum disorder (PASD) and placenta previa (PP) are two of the most hideous obstetric complications which are usually associated with a history of cesarean section (CS). Moreover, women with PASD, PP and/or a cesarean scarred uterus are more likely to have adverse pregnancy outcomes, including blood transfusion, hysterectomy, pelvic organs damage, postpartum hemorrhage, disseminated intravascular coagulation, multi-organ dysfunction syndrome and even maternal or fetal death. This study aimed to investigate the efficacy of precesarean internal iliac artery balloon catheterization (BC) for managing severe hemorrhage caused by PASD and PP with a history of CS. Read More

BMC Pregnancy Childbirth 2021 Apr 16;21(1):306. Epub 2021 Apr 16.

Obstetrics and Gynaecology Department, IRCCS San Raffaele Hospital and University, via Olgettina 62, Milan, 20132, Italy.

Background: Etiopathogenesis of preterm birth (PTB) is multifactorial, with a universe of risk factors interplaying between the mother and the environment. It is of utmost importance to identify the most informative factors in order to estimate the degree of PTB risk and trace an individualized profile. The aims of the present study were: 1) to identify all acknowledged risk factors for PTB and to select the most informative ones for defining an accurate model of risk prediction; 2) to verify predictive accuracy of the model and 3) to identify group profiles according to the degree of PTB risk based on the most informative factors. Read More

Indian J Pathol Microbiol 2021 Apr-Jun;64(2):288-293

Department of Obstetrics and Gynecology, Fujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China.

Objectives: To explore the effects of maternal and fetal outcomes after different diagnostic timings of placenta accreta and its types.

Methods: We retrospectively collected the clinical information of 1178 pregnant women with placenta accreta in Fujian Maternity and Children Health Hospital from January 2012 to January 2017. According to the different diagnostic timings of placenta accreta, they were divided into groups of prenatal diagnosis and postpartum diagnosis; and according to the types of placenta accreta, they were divided into groups of accreta group, increta group, and percreta group. Read More

J Matern Fetal Neonatal Med 2021 Apr 11:1-5. Epub 2021 Apr 11.

CYMSA Clínica y Maternidad Suizo Argentina, Buenos Aires, Argentina.

Aim: To report the outcome of pregnant women with a prior pregnancy complicated by placenta accreta spectrum (PAS) disorders treated with resective-conservative surgery at the time of cesarean section.

Materials And Methods: Retrospective analysis of pregnant women treated with conservative surgery in the prior pregnancy complicated by PAS disorders. The primary outcome was spontaneous preterm birth with intact membranes or following a preterm labor rupture of the membranes before 37 weeks of gestation. Read More

Zhongguo Dang Dai Er Ke Za Zhi 2021 Apr;23(4):369-374

Department of Neonatology, Health Center for Children and Women, Chongqing 401147, China.

Objective: To explore the risk factors for endotracheal intubation during resuscitation in the delivery room among very preterm infants.

Methods: A retrospective analysis was performed for 455 very preterm infants who were admitted to the neonatal intensive care unit from January 2017 to December 2019. They were divided into an intubation group (=79) and a non-intubation group (=376) according to whether endotracheal intubation was performed during resuscitation. Read More

Arch Gynecol Obstet 2021 Apr 10. Epub 2021 Apr 10.

Department of Obstetrics and Gynecology, Department of Neonatology, Sheba Medical Center, Tel-Hashomer, Ramat Gan, Israel.

Purpose: Relaparotomy following cesarean delivery (CD) is performed at a rate of 0.2-1% of CD. The objective of the present study was to identify risk factors for relaparotomy following CD, and to examine whether there is a difference in the risk of relaparotomy between CD performed during different hours of the day. Read More

Reprod Biol Endocrinol 2021 Apr 9;19(1):55. Epub 2021 Apr 9.

Center for Reproductive Medicine, Shandong University, No.157 Jingliu Road, Jinan, 250021, China.

Background: Thin endometrial thickness (EMT) has been suggested to be associated with reduced incidence of pregnancy rate after in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatment, but the effect of thin endometrium on obstetric outcome is less investigated. This study aims to determine whether EMT affects the incidence of obstetric complications in fresh IVF/ICSI-embryo transfer (ET) cycles.

Methods: We conducted a retrospective cohort study collecting a total of 9266 women who had singleton livebirths after fresh IVF/ICSI-ET treatment cycles at the Center for Reproductive Medicine Affiliated to Shandong University between January 2014 and December 2018. Read More

Reprod Sci 2021 Apr 6. Epub 2021 Apr 6.

Department of Obstetrics & Gynecology, the Edith Wolfson Medical Center, Holon, Israel affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

The uterine location of placenta previa (PP), anterior vs. posterior has an impact on pregnancy outcome. We aimed to study maternal and neonatal outcome and placental histopathology lesions in anterior vs. Read More

Acta Obstet Gynecol Scand 2021 03;100 Suppl 1:50-57

Department of Obstetrics and Gynaecology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

Introduction: It has been suggested that women with obesity have increased risk of developing placenta accreta spectrum (PAS). It is unclear if this is independent of the increased risk of cesarean delivery seen with obesity itself. The aim of this study was to explore the association between maternal obesity and PAS, particularly severe PAS (percreta). Read More

Life (Basel) 2021 Mar 24;11(4). Epub 2021 Mar 24.

Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Ac. Oparina 4, 117997 Moscow, Russia.

Magnetic resonance imaging (MRI) and ultrasound methods used for the diagnosis of an abnormally invasive placenta (AIP) have a wide range of sensitivity (Se, 33-93%) and specificity (Sp, 71-100%) levels, which results in a high risk of unfavorable maternal and perinatal outcomes. The relevance of optimizing the diagnosis of AIP is beyond doubt. Given the epigenetic nature of trophoblast invasion, we aimed to quantitate microRNAs and proteins of their target genes that are potentially associated with AIP in blood plasma samples from 64 pregnant women at gestation weeks 30-34 by reverse transcription coupled with polymerase chain reaction (RT-PCR) and Western blotting, respectively. Read More

PLoS One 2021 1;16(4):e0249411. Epub 2021 Apr 1.

School of Mathematics, Statistics and Computer Science, University of KwaZulu-Natal, Pietermaritzburg, South Africa.

Background: Preterm birth is a significant contributor of under-five and newborn deaths globally. Recent estimates indicated that, Tanzania ranks the tenth country with the highest preterm birth rates in the world, and shares 2.2% of the global proportion of all preterm births. Read More