4,587 results match your criteria Placenta [Journal]


IFPA meeting 2018 workshop report II: Abnormally invasive placenta; inflammation and infection; preeclampsia; gestational trophoblastic disease and drug delivery.

Placenta 2019 Feb 12. Epub 2019 Feb 12.

Mother Infant Research Institute, Tufts Medical Center, Boston, MA, USA. Electronic address:

Workshops are an important part of the IFPA annual meeting as they allow for discussion of specialized topics. At IFPA meeting 2018 there were nine themed workshops, five of which are summarised in this report. These workshops discussed new perspectives and knowledge in the following areas of research: 1) preeclampsia; 2) abnormally invasive placenta; 3) placental infection; 4) gestational trophoblastic disease; 4) drug delivery to treat placental dysfunction. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2019.02.006DOI Listing
February 2019

IFPA meeting 2018 workshop report I: Reproduction and placentation among ocean-living species; placental imaging; epigenetics and extracellular vesicles in pregnancy.

Placenta 2019 Feb 10. Epub 2019 Feb 10.

Mother Infant Research Institute, Tufts Medical Center, USA. Electronic address:

Workshops are an important part of the IFPA annual meeting as they allow for discussion of specialized topics. At IFPA meeting 2018 there were nine themed workshops, four of which are summarized in this report. These workshops discussed new knowledge and technological innovations in the following areas of research: 1) viviparity in ocean-living species; 2) placental imaging; 3) epigenetics; and 4) extracellular vesicles in pregnancy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2019.02.003DOI Listing
February 2019

Corrigendum to "Placental pathologic changes and perinatal outcomes in placenta previa" [Placenta 63 C (2018) 15-20].

Placenta 2019 Feb 13. Epub 2019 Feb 13.

Department of Obstetrics and Gynecology, Inje University Busan Paik Hospital, Busan, South Korea; Paik Institute for Clinical Research, Inje University Busan Paik Hospital, Busan, South Korea. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2018.12.011DOI Listing
February 2019

Progestin therapy to prevent preterm birth: History and effectiveness of current strategies and development of novel approaches.

Placenta 2019 Jan 28. Epub 2019 Jan 28.

Department of Biochemistry, Case Western Reserve University, Cleveland, OH, USA.

In the 1930s the "progestin" hormone produced by the corpus luteum was isolated and found to be a Δ-keto-steroid. It was aptly named progesterone (P4) and in the following 30 years the capacity of P4 and derivatives to prevent preterm birth (PTB) was examined. Outcomes of multiple small studies suggested that progestin prophylaxis beginning at mid-gestation decreases the risk for PTB. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2019.01.018DOI Listing
January 2019
1 Read

The untapped potential of placenta-enriched molecules for diagnostic and therapeutic development.

Placenta 2019 Feb 4. Epub 2019 Feb 4.

Translational Obstetrics Group, Department of Obstetrics and Gynecology, Mercy Hospital for Women, University of Melbourne, Heidelberg, Victoria, 3084, Australia; Mercy Perinatal, Mercy Hospital for Women, Victoria, Australia. Electronic address:

Pregnancy complications such as fetal growth restriction and preeclampsia are diseases with limited biomarkers for prediction, and a complete lack of therapeutic options. We define placenta-enriched molecules as those that are highly expressed in the placenta relative to all other human tissues. Many exist including mRNAs, miRNAs and proteins. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2019.02.002DOI Listing
February 2019
2 Reads

Differential effect of LPS and IL-1β in term placental explants.

Placenta 2019 Jan 22;75:9-15. Epub 2018 Nov 22.

Ste-Justine Hospital Research Centre, Department of Obstetrics and Gynecology, Universite de Montreal, 3175, chemin de la Côte-Sainte-Catherine, Montreal, Quebec, H3T 1C5, Canada; Department of Pharmacology and Physiology, Universite de Montreal, 2900 Edouard-Montpetit Boulevard, Montreal, Quebec, H3T 1J4, Canada; Department of Microbiology, Infectiology, and Immunology, Universite de Montreal, 2900 Edouard-Montpetit Boulevard, Montreal, Quebec, H3T 1J4, Canada. Electronic address:

Introduction: Inflammation is an important cause of placental dysfunction often associated with pregnancy complications. One well-known cause of inflammation is infection, through conserved "pathogen-associated molecular patterns" (PAMPs). Endogenous inducers of inflammation, known as "damage-associated molecular patterns" (DAMPs), have also been associated with pathological pregnancies and could contribute to the observed placental inflammation. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01434004183069
Publisher Site
http://dx.doi.org/10.1016/j.placenta.2018.11.006DOI Listing
January 2019
5 Reads

Histopathological analysis of placentas with congenital cytomegalovirus infection.

Placenta 2019 Jan 4;75:62-67. Epub 2019 Jan 4.

Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe, Japan. Electronic address:

Introduction: Cytomegalovirus (CMV) infection is the most common cause of congenital viral infections in humans. The unusual structure of the placenta plays a pivotal role in CMV transmission from mothers to fetuses. The aim of this study was to evaluate the histopathological findings of placentas with congenital CMV infections. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2019.01.003DOI Listing
January 2019
1 Read

The Angiotensin II type 1 receptor mediates the effects of low oxygen on early placental angiogenesis.

Placenta 2019 Jan 6;75:54-61. Epub 2018 Dec 6.

School of Biomedical Sciences and Pharmacy, Priority Research Centre for Reproductive Sciences, Hunter Medical Research Institute, University of Newcastle, Newcastle, New South Wales, Australia. Electronic address:

Introduction: Placental development occurs in a low oxygen environment, which stimulates angiogenesis by upregulating vascular endothelial growth factor A (VEGFA), plasminogen activator inhibitor-1 (SERPINE1) and the angiopoietin-2/-1 ratio (ANGPT2/1). At this time, Angiotensin II type 1 receptor (ATR) is highly expressed. We postulated that the early gestation placental oxygen milieu, by stimulating the angiotensin (Ang) II/ATR pathway, increases expression of proliferative/angiogenic factors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2018.12.001DOI Listing
January 2019

FUT8 drives the proliferation and invasion of trophoblastic cells via IGF-1/IGF-1R signaling pathway.

Placenta 2019 Jan 22;75:45-53. Epub 2018 Nov 22.

Department of Biochemistry and Molecular Biology, Dalian Medical University, Liaoning Provincial Core Lab of Glycobiology and Glycoengineering, Dalian, People's Republic of China. Electronic address:

Introduction: Trophoblast proliferation and invasion are essential for embryo implantation and placentation. Protein glycosylation is one of the most common and vital post-translational modifications, regulates protein physical and biochemical properties. FUT8 is the only known fucosyltransferase responsible for catalyzing α1,6-fucosylation in mammals, and α1,6-fucosylated glycoproteins are found to participate in various physiopathological processes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2018.11.005DOI Listing
January 2019
2 Reads

Isolated acute funisitis in the absence of acute chorioamnionitis: What does it mean?

Placenta 2019 Jan 5;75:42-44. Epub 2018 Dec 5.

Weill Cornell Medical College, Department of Pathology and Laboratory Medicine, 520 E 70th St, New York, NY, 10065, USA. Electronic address:

Objective: Acute funisitis (AF) is most commonly associated with acute chorioamnionitis (AC) and ascending infection. The significance of cases of AF without associated AC or isolated funisitis (IF) is unknown. Our objective was to evaluate clinical and pathologic features of IF and to determine its significance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2018.12.002DOI Listing
January 2019
1 Read

Analysis of the effects of polyunsaturated fatty acids on transporter expressions using a PCR array: Induction of xCT/SLC7A11 in human placental BeWo cells.

Placenta 2019 Jan 27;75:34-41. Epub 2018 Nov 27.

Laboratory of Clinical Pharmaceutics & Therapeutics, Division of Pharmasciences, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12-jo, Nishi-6-chome, Kita-ku, Sapporo, 060-0812, Japan; Department of Pharmacy, Hokkaido University Hospital, Kita-14-jo, Nishi-5-chome, Kita-ku, Sapporo, 060-8648, Japan. Electronic address:

Objective: Polyunsaturated fatty acids (PUFAs), including arachidonic acid (AA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), are essential for adequate fetal growth. The aim of the present study was to elucidate the effects of PUFAs on the expression and function of placental transporters, which play important roles in placental functions including the supply of nutrients to the fetus, excretion of metabolites, and protection of the fetus from xenobiotics.

Methods: Human placental choriocarcinoma BeWo cells were used as a trophoblast model. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2018.11.010DOI Listing
January 2019
1 Read

Fetal human leukocyte antigen-C and maternal killer-cell immunoglobulin-like receptors in cases of severe preeclampsia.

Placenta 2019 Jan 22;75:27-33. Epub 2018 Nov 22.

Centre for Immune Regulation and Reproductive Immunology (CIRRI), Department of Clinical Biochemistry, The ReproHealth Research Consortium ZUH, Zealand University Hospital, Department of Clinical Medicine, University of Copenhagen, Denmark. Electronic address:

Introduction: The pathogenesis of preeclampsia may involve inadequate trophoblast invasion caused by excessive inhibition of uterine natural killer cells (uNK) by extravillous trophoblast cells (EVT). This may be the result of a combination of maternal killer-cell immunoglobin-like receptor (KIR) AA genotype and fetal human leukocyte antigen-C2 (HLA-C2) genotype. A few studies have reported a significantly increased frequency of the maternal KIR AA/fetal HLA-C2 combination in cases of preeclampsia compared to controls. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2018.11.008DOI Listing
January 2019
1 Read

SLC11A1 is expressed in the human placenta across multiple gestational ages.

Placenta 2019 Jan 22;75:23-26. Epub 2018 Nov 22.

Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. Electronic address:

The human placenta functions as an innate immune barrier to prevent fetal infection. However, the molecular mechanisms accounting for placental resistance to pathogens are currently poorly understood. The solute carrier family 11 member 1 (SLC11A1) is a divalent cation transporter expressed primarily by macrophages and neutrophils that is essential for controlling infections by intracellular pathogens such as Salmonella, Leishmania and Mycobacteria. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2018.11.009DOI Listing
January 2019
1 Read

Comparative transcriptome analysis of embryo invasion in the mink uterus.

Placenta 2019 Jan 16;75:16-22. Epub 2018 Nov 16.

Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun, China; State Key Laboratory for Molecular Biology of Special Economic Animal and Plant Science, Chinese Academy of Agricultural Sciences, Changchun, China.

Introduction: In mink, as many as 65% of embryos die during gestation. The causes and the mechanisms of embryonic mortality remain unclear. The purpose of our study was to examine global gene expression changes during embryo invasion in mink, and thereby to identify potential signaling pathways involved in implantation failure and early pregnancy loss. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2018.11.004DOI Listing
January 2019
1 Read
2.710 Impact Factor

Pravastatin improves fetal survival in mice with a partial deficiency of heme oxygenase-1.

Placenta 2019 Jan 14;75:1-8. Epub 2018 Nov 14.

Dept of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Stanford, CA, USA.

Introduction: Statins induce heme oxygenase-1 (HO-1) expression in vitro and in vivo. Low HO-1 expression is associated with pregnancy complications, e.g. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2018.11.001DOI Listing
January 2019
1 Read

Retraction notice to "Invasion of trophoblast cell lines is inhibited by miR-93 via MMP-2" [YPLAC 53C (2017) 48-53].

Placenta 2018 12;74:62

Laboratory of Clinical Genetics, Huaian Maternity and Child Health Care Hospital of Jiangsu Province, Yangzhou University, Huaian, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2018.11.002DOI Listing
December 2018
2.710 Impact Factor

Corrigendum to "Phthalate metabolites and bisphenol-A in association with circulating angiogenic biomarkers across pregnancy" [Placenta 36 (2015) 699-703].

Placenta 2019 Jan 18. Epub 2019 Jan 18.

Department of Environmental Health Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109-2029, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2019.01.004DOI Listing
January 2019
1 Read

Determinants and outcomes of preterm births at a tertiary hospital in Ghana.

Placenta 2019 Jan 8. Epub 2019 Jan 8.

Department of Obstetrics and Gynecology, School of Medicine and Dentistry, University of Ghana, Accra, Ghana.

Introduction: Preterm birth remains an important clinical challenge with significant short and long-term complications although its burden in the developing world is not adequately explored. This study determines the incidence, specific determinants and outcomes of preterm birth at a teaching hospital in Ghana.

Methods: Retrospective review of singleton births at Korle-Bu Teaching Hospital (KBTH) in Ghana between 1st January to 31st December, 2015. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2019.01.007DOI Listing
January 2019
1 Read

Integrated RNA-seq and ChIP-seq analysis reveals a feed-forward loop regulating H3K9ac and key labor drivers in human placenta.

Placenta 2019 Jan 10. Epub 2019 Jan 10.

Department of Obstetrics, Gynecology, and Reproductive Sciences, Division of Maternal-Fetal Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, 08901, USA. Electronic address:

Background: Chromatin alterations are important mediators of gene expression changes. We have recently shown that activated non-canonical NF-κB signaling (RelB/p52) recruits histone acetyltransferase CBP and deacetylase HDAC1 to selectively acetylate H3K9 (H3K9ac) to induce expression of corticotropin-releasing hormone (CRH) and prostaglandin-endoperoxide synthase-2 (PTGS2) in the human placenta. Both of these genes play a role in initiating parturition in human pregnancy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2019.01.010DOI Listing
January 2019
1 Read

Considerations when processing and interpreting genomics data of the placenta.

Placenta 2019 Jan 7. Epub 2019 Jan 7.

BC Children's Hospital Research Institute, 950 West 28th Ave, Vancouver, BC V5Z 4H4, Canada; Department of Medical Genetics, University of British Columbia, 4500, Oak Street, Vancouver, BC V6H3N1, Canada. Electronic address:

The application of genomic approaches to placental research has opened exciting new avenues to help us understand basic biological properties of the placenta, improve prenatal screening/diagnosis, and measure effects of in utero exposures on child health outcomes. In the last decade, such large-scale genomic data (including epigenomics and transcriptomics) have become more easily accessible to researchers from many disciplines due to the increasing ease of obtaining such data and the rapidly evolving computational tools available for analysis. While the potential of large-scale studies has been widely promoted, less attention has been given to some of the challenges associated with processing and interpreting such data. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01434004183114
Publisher Site
http://dx.doi.org/10.1016/j.placenta.2019.01.006DOI Listing
January 2019
5 Reads

Elevated protease HtrA4 in the maternal circulation of preeclampsia may contribute to endothelial barrier disruption by cleaving key junctional protein VE-cadherin.

Placenta 2019 Jan 2. Epub 2019 Jan 2.

Implantation and Placental Development Laboratory, Centre for Reproductive Health, Hudson Institute of Medical Research, Clayton, VIC, Australia; Department of Molecular and Translational Science, Monash University, Clayton, VIC, Australia; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC, Australia. Electronic address:

Preeclampsia is hallmarked by systemic endothelial dysfunction, including increased endothelial permeability and oedema. Placenta-derived factors in maternal blood contribute to endothelial barrier impairment, but molecular mechanisms are unclear. HtrA4 is a placenta-specific protease that is secreted into the maternal circulation and elevated in early-onset preeclampsia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2019.01.001DOI Listing
January 2019
2 Reads

Maternal exercise and growth restriction in rats alters placental angiogenic factors and blood space area in a sex-specific manner.

Placenta 2018 Dec 15;74:47-54. Epub 2018 Dec 15.

Department of Physiology, The University of Melbourne, Parkville, VIC, 3010, Australia. Electronic address:

Fetal growth and development are dependent on adequate placental nutrient transfer. The surface area of the placental villous network is a key determinant of nutrient exchange, which is regulated by vasculogenic and angiogenic factors. These factors are altered by intrauterine growth restriction (IUGR) and maternal obesity in both the first (F1) and second (F2) generations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2018.12.005DOI Listing
December 2018
1 Read

Major histocompatibility complex class I in the horse (Equus caballus) placenta during pregnancy and parturition.

Placenta 2018 Dec 24;74:36-46. Epub 2018 Dec 24.

Department of Animal Reproduction with Clinic, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Poland.

Background: Major histocompatibility protein class I (MHC-I) is believed to be expressed in the horse allantochorion only in limited areas at limited times. However, its expression has only been investigated in early pregnancy with non-quantitative techniques that cannot reliably detect small amounts of protein.

Objective: To quantify the relative expression of MHC-I in the allantochorion and endometrium during days 90-240 of pregnancy (PREG), parturition with physiological delivery of fetal membranes (PHYS), and parturition with retention of these membranes (FMR). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2018.12.006DOI Listing
December 2018
1 Read

Inter-twin hemoglobin difference at birth in uncomplicated monochorionic twins in relation to the size of the placental anastomoses.

Placenta 2018 Dec 2;74:28-31. Epub 2019 Jan 2.

Division of Neonatology, Department of Pediatrics, Leiden University Medical Center, Leiden, the Netherlands.

Objective: To evaluate the relation between Hb levels and the size of the placental anastomoses.

Methods: We performed a retrospective review of all uncomplicated MC twins delivered vaginally at our center from 2002 to 2017. Hb levels at birth and on day 2 were retrieved. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01434004183102
Publisher Site
http://dx.doi.org/10.1016/j.placenta.2019.01.002DOI Listing
December 2018
6 Reads

Imaging the placental glycocalyx with transmission electron microscopy.

Placenta 2018 Dec 13;74:59-61. Epub 2018 Dec 13.

Department of Fetal Medicine, St Michael's Hospital, University Hospitals Bristol NHS Foundation Trust, UK.

There is a significant glycocalyx present at the maternal-fetal interface of the human placenta, with increasing evidence to suggest it has an important role in placental function. Glycocalyx is adversely affected by traditional tissue processing and fixation techniques. Using transmission electron microscopy, we present methodologies for reliably imaging and measuring glycocalyx of both the syncytiotrophoblast and fetal capillary endothelium in term healthy placentae. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2018.12.004DOI Listing
December 2018
2 Reads

Placental findings in non-hypertensive term pregnancies and association with future adverse pregnancy outcomes: a cohort study.

Placenta 2018 Dec 21;74:14-19. Epub 2018 Dec 21.

Departments of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, 300 Halket Street, Pittsburgh, PA, USA; Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, 130 DeSoto Street, Pittsburgh, PA, USA.

Introduction: Women with adverse pregnancy outcomes (APOs) have excess risk of later life cardiovascular disease (CVD) perhaps related to an underlying high-risk vascular phenotype. We sought to determine if placental evidence of maternal malperfusion in uncomplicated pregnancies is associated with an increased risk of APOs in subsequent pregnancies.

Methods: 536 women with more than one delivery and an initial uncomplicated pregnancy with placental pathology examination between 2008 and 2012 were included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2018.12.008DOI Listing
December 2018
1 Read

Changes in intrapartum maternal placental growth factor levels in pregnancies complicated by fetal compromise at term.

Placenta 2018 Dec 22;74:9-13. Epub 2018 Dec 22.

Mater Research Institute - University of Queensland, South Brisbane, Queensland, QLD 4101, Australia; Mater Mother's Hospital, Raymond Terrace, South Brisbane, Queensland, QLD 4101, Australia; Faculty of Medicine, The University of Queensland, Brisbane, Australia. Electronic address:

Background: Intrapartum fetal compromise (IFC) may result from the gradual decline in placental function during labour and can precipitate adverse neonatal outcomes. Placental growth factor (PlGF) is a biomarker of placental function. This study aims to investigate maternal PlGF levels and adverse perinatal outcomes in term labour. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2018.12.010DOI Listing
December 2018
2 Reads

Tumor necrosis factor-α regulates angiogenesis of BeWo cells via synergy of PlGF/VEGFR1 and VEGF-A/VEGFR2 axes.

Placenta 2018 Dec 24;74:20-27. Epub 2018 Dec 24.

Kyorin University School of Medicine, Department of Obstetrics and Gynecology, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan.

Objectives: Tumor necrosis factor-alpha (TNF- α) promotes tumor growth by enhancing tumor angiogenesis; however, the effects on choriocarcinoma remain unknown. We investigated the effects of TNF-α on the production of placental growth factor (PlGF) and vascular endothelial growth factor-A (VEGF-A) in BeWo cells and also examined its significance on the interactions with the endothelial cells by using human umbilical vein endothelial cells (HUVECs).

Materials & Methods: After incubation with TNF-α (10-10 pg/mL), the expression of PlGF and VEGF-A in BeWo cells were assessed by ELISA and RT-PCR. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2018.12.009DOI Listing
December 2018
1 Read

MicroRNA-423-5p inhibits the progression of trophoblast cells via targeting IGF2BP1.

Placenta 2018 Dec 7;74:1-8. Epub 2018 Dec 7.

Department of Obstetrics and Gynecology, Xijing Hospital,the Military Medical University of PLA Airforce (Fourth Military Medical University), China. Electronic address:

Introduction: Preeclampsia (PE) is one of the leading causes of maternal and fetal mortality globally. The imbalance of trophoblast homeostasis is closely linked with the pathogenesis of PE. MicroRNA-423-5p (miR-423-5p) has been reported to be abnormally expressed in placenta and blood plasma of pregnant women with PE. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01434004183018
Publisher Site
http://dx.doi.org/10.1016/j.placenta.2018.12.003DOI Listing
December 2018
7 Reads

Isolation of villous cytotrophoblasts from second trimester human placentas.

Placenta 2018 Dec 22;74:55-58. Epub 2018 Nov 22.

Robinson Research Institute, University of Adelaide, Adelaide, SA, 5005, Australia; Adelaide Medical School, University of Adelaide, Adelaide, SA, 5000, Australia.

Human placental functional studies are often performed using immortalised trophoblast cells and cell lines established from human choriocarcinomas, which, while practical, may not truly reflect trophoblast function in vivo. Primary trophoblast cultures derived from human placentas following pregnancy termination or delivery are more clinically relevant, but trophoblast isolation protocols are only available for 1st trimester and term placental tissues. Here we report a method for isolation and purification of primary villous cytotrophoblasts from 2nd trimester human placentas, that yields >99% trophoblast purity as shown by immunofluorescence. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2018.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358491PMC
December 2018
1 Read

Effects of selective serotonin-reuptake inhibitors (SSRIs) in JEG-3 and HIPEC cell models of the extravillous trophoblast.

Placenta 2018 Dec 30;72-73:62-73. Epub 2018 Oct 30.

INRS-Institut Armand-Frappier, 531 boulevard des Prairies, Laval, QC, H7V 1B7, Canada. Electronic address:

Introduction: Between 2 and 10% of pregnant women are treated with selective serotonin-reuptake inhibitors (SSRIs) for depression. The extravillous trophoblasts (evTBs), which migrate and invade maternal tissues, are crucial for embryo implantation and remodeling of maternal spiral arteries. Poor migration/invasion of evTBs can cause serious pregnancy complications, yet the effects of SSRIs on these processes has never been studied. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2018.10.007DOI Listing
December 2018
2 Reads

Placental inflammation by HMGB1 activation of TLR4 at the syncytium.

Placenta 2018 Dec 2;72-73:53-61. Epub 2018 Nov 2.

Centre of Molecular Inflammation Research (CEMIR), Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), NO-7491, Trondheim, Norway. Electronic address:

Introduction: Normal pregnancy is characterized by an elevated inflammatory state involving the placenta. The placental inflammation is further increased in preeclampsia, resulting in release of harmful danger signals to the maternal circulation. Activation of toll-like receptors (TLR)2 and TLR4 by endogenous danger signals plays a role in inflammatory diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2018.10.011DOI Listing
December 2018
13 Reads
2.710 Impact Factor

Comparative expression patterns of selected membrane transporters in differentiated BeWo and human primary trophoblast cells.

Placenta 2018 Dec 29;72-73:48-52. Epub 2018 Oct 29.

Institute of Biochemistry and Molecular Medicine, University of Bern, Switzerland; Swiss National Centre of Competence in Research, NCCR TransCure, University of Bern, Switzerland. Electronic address:

Although placental membrane transporters have an important impact on materno-fetal nutrient transfer, placental cell models are poorly characterized regarding transporter expression. We assessed the mRNA expression of 26 physiologically important solute carriers and ABC transporters in BeWo (b30 clone) and primary human trophoblast cells (PHT) before and after syncytialization. 77% of the transporters showed similar mRNA expression changes between BeWo and PHT after syncytialization. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2018.10.008DOI Listing
December 2018
2 Reads

Estimation of the burden of human placental micro- and nano-vesicles extruded into the maternal blood from 8 to 12 weeks of gestation.

Placenta 2018 Dec 30;72-73:41-47. Epub 2018 Oct 30.

The Hospital of Obstetrics & Gynaecology, Fudan University, China; Department of Obstetrics & Gynaecology, The University of Auckland, New Zealand. Electronic address:

Background: The human placenta extrudes a variety of extracellular vesicles (EVs) into the maternal blood daily. These vesicles may be crucial to the adaptation of the maternal cardiovascular and immune systems to pregnancy. Quantifying the EVs that are released in early gestation is important to our understanding of how placental EVs may contribute to the regulation of maternal physiology. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2018.10.009DOI Listing
December 2018
2 Reads
2.710 Impact Factor

Progressive uterine artery occlusion in the Guinea pig leads to defects in placental structure that relate to fetal growth.

Placenta 2018 Dec 17;72-73:36-40. Epub 2018 Oct 17.

Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, Downing Street, University of Cambridge, Cambridge, CB2 3EG, UK. Electronic address:

Intrauterine growth restriction (IUGR) is a common obstetric complication with immediate and life-long consequences for offspring health. Yet the mechanisms underlying its aetiology require elucidation. Recent work in the guinea pig shows that progressive uterine artery occlusion induced IUGR and vascular dysfunction in pups. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01434004183071
Publisher Site
http://dx.doi.org/10.1016/j.placenta.2018.10.003DOI Listing
December 2018
2 Reads
2.710 Impact Factor

Distinct communication patterns of trophoblastic miRNA among the maternal-placental-fetal compartments.

Placenta 2018 Dec 22;72-73:28-35. Epub 2018 Oct 22.

Magee-Womens Research Institute, USA; Department of Obstetrics and Gynecology and Reproductive Science, University of Pittsburgh, Pittsburgh, PA, 15213, USA; Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, 15213, USA. Electronic address:

Introduction: The placenta produces microRNAs (miRNA) that may traffic to the maternal or fetal compartments and influence the physiology of pregnancy. The trafficking patterns of miRNA expressed from the large human chromosome 19 and chromosome 14 clusters (C19MC and C14MC), remains unclear. We interrogated the cross-sectional landscape of miRNA expression within the human placenta, fetal and maternal plasma to elucidate miRNA trafficking. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2018.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329371PMC
December 2018
2 Reads

Polymer size affects biodistribution and placental accumulation of the drug delivery biopolymer elastin-like polypeptide in a rodent pregnancy model.

Placenta 2018 Dec 20;72-73:20-27. Epub 2018 Oct 20.

Department of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, MS, USA; Department of Neurology, University of Mississippi Medical Center, Jackson, MS, USA. Electronic address:

Introduction: Fusion of therapeutic agents to Elastin-like Polypeptide (ELP) is a novel drug delivery strategy for prevention of placental drug transfer. Previous studies have used a 60 kDa ELP tag for this purpose. However, placental transfer of ELP may be size dependent. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2018.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287274PMC
December 2018
2 Reads

Human cytomegalovirus utilises cellular dual-specificity tyrosine phosphorylation-regulated kinases during placental replication.

Placenta 2018 Dec 13;72-73:10-19. Epub 2018 Oct 13.

Serology and Virology Division, SEALS Microbiology, Prince of Wales Hospital, Sydney, Australia; School of Women's and Children's Health, University of New South Wales, Australia; School of Medical Sciences, University of New South Wales, Australia; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia. Electronic address:

Introduction: Congenital cytomegalovirus (HCMV) infection may cause significant fetal malformation and in severe cases fetal and neonatal death. Fetal injury may be caused indirectly by the placental response to infection. Dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs) have recently been identified as critical kinases for HCMV replication. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2018.10.002DOI Listing
December 2018
2 Reads

Real-time microscopic assessment of fatty acid uptake kinetics in the human term placenta.

Placenta 2018 Dec 31;72-73:1-9. Epub 2018 Jul 31.

School of Medicine, Oregon Health and Science University, Portland, OR, 97239, USA; Center for Developmental Health, Knight Cardiovascular Institute Oregon Health and Science University, Portland, OR, 97239, USA; Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR, 97239, USA; Department of Medicine, Oregon Health and Science University, Portland, OR, 97239, USA. Electronic address:

Introduction: The placenta employs an efficient and selective fatty acid transport system to supply lipids for fetal development. Disruptions in placental fatty acid transport lead to restricted fetal growth along with cardiovascular and neurologic deficits. Nevertheless, little is known about the molecular mechanisms involved in human placental fatty acid trafficking during the initial steps of uptake, or the importance of fatty acid chain length in determining uptake rates. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2018.07.014DOI Listing
December 2018
2 Reads

Fetal membrane architecture, aging and inflammation in pregnancy and parturition.

Placenta 2018 Nov 10. Epub 2018 Nov 10.

Obstetrics, Nutrition and Endocrinology Group, Department of Obstetrics and Gynaecology, University of Melbourne, Mercy Hospital for Women, Heidelberg, Victoria, Australia; Department of Obstetrics and Gynaecology, University of Melbourne, Mercy Hospital for Women, Heidelberg, Victoria, Australia. Electronic address:

Preterm birth is the single major cause of infant mortality. Short and long term outcomes for infants are often worse in cases of preterm premature rupture of the fetal membranes (pPROM). Thus, increased knowledge of the structure characteristics of fetal membranes as well as the mechanisms of membrane rupture are essential if we are to develop effective treatment strategies to prevent pPROM. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2018.11.003DOI Listing
November 2018
16 Reads

Endogenous carbon monoxide production by menadione.

Placenta 2018 Nov 28;71:6-12. Epub 2018 Sep 28.

Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, K7L 3N6, Canada; Department of Obstetrics and Gynaecology, Queen's University, Kingston, Ontario, K7L 3N6, Canada. Electronic address:

Introduction: Smokers have a significantly decreased risk of pre-eclampsia (PE), possibly attributed to an increase in blood carbon monoxide (CO) concentrations. At physiological concentrations, CO has been demonstrated to have placental vasodilatory and anti-inflammatory properties. Increasing endogenous CO production may have therapeutic potential to either prevent or treat PE. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2018.09.007DOI Listing
November 2018
2 Reads

Immunomodulatory effects of human amniotic epithelial cells on naive CD4 T cells from women with unexplained recurrent spontaneous abortion.

Placenta 2018 Nov 18;71:31-40. Epub 2018 Jun 18.

Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address:

Introduction: Immune imbalance at the maternal-fetal interface plays a fundamental role in the pathogenesis of unexplained recurrent spontaneous abortion (URSA). Human amniotic epithelial cells (hAECs) possess pregnancy-friendly immunomodulatory effects. Here, we investigated how function of naive CD4 T cells from URSA patients is affected by hAECs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2018.06.008DOI Listing
November 2018
2 Reads

Approach for differentiating trophoblast cell lineage from human induced pluripotent stem cells with retinoic acid in the absence of bone morphogenetic protein 4.

Placenta 2018 Nov 10;71:24-30. Epub 2018 Oct 10.

Laboratory of Clinical Pharmaceutics, Faculty of Pharmacy, Osaka Ohtani University, Osaka, Japan.

Introduction: Placental transport is the first step in chemotherapeutic safety evaluations during pregnancy. However, a well-established in vitro model is not available. We previously reported that a trophoblast layer model using differentiating choriocarcinoma JEG-3 cells (DJEGs) can be used for placental drug transport studies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2018.10.001DOI Listing
November 2018
5 Reads

Immunohistochemical expression of the nicotinic acetylcholine receptor (nAChR) subunits in the human placenta, and effects of cigarette smoking and preeclampsia.

Placenta 2018 Nov 4;71:16-23. Epub 2018 Oct 4.

Vascular Immunology Research Laboratory, The Heart Research Institute, University of Sydney, Camperdown, NSW, Australia; School of Medicine, Western Sydney University, NSW, 2751, Australia.

Introduction: Cigarette smoking (CS) and preeclampsia (PE), regulate the expression of nicotinic acetylcholine receptor (nAChR) subunits in the placenta, yet no data exist at the histological level.

Methods: Using immunohistochemistry of formalin fixed and paraffin embedded placental tissue, this study quantified the expression of nine nAChR subunits (α2, α3, α4, α5, α7, α9, β1, β2, δ) and compared the expression amongst four groups of non-smoker non-PE (controls, n = 8), smokers (n = 8), PE (n = 8), and those who were smokers with PE (smoke + PE, n = 4). Quantification was of the percentage of villi with positive cells stained (% villi with +ve), percentage of positive stained cells per villous (% +ve cells/villous), percentage of positive cells in the decidua (%+ve Decidua), and intensity of staining in the outer villous trophoblast layer. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01434004183027
Publisher Site
http://dx.doi.org/10.1016/j.placenta.2018.09.008DOI Listing
November 2018
9 Reads

Serum podocalyxin for early detection of preeclampsia at 11-13 weeks of gestation.

Placenta 2018 Nov 2;71:13-15. Epub 2018 Oct 2.

Implantation and Placental Development Laboratory, Centre for Reproductive Health, Hudson Institute of Medical Research, Clayton, VIC, Australia; Department of Molecular and Translational Science, Monash University, Clayton, VIC, Australia; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC, Australia. Electronic address:

Podocalyxin is expressed on endothelial surface throughout the body and is likely released into the circulation during pregnancy in association with vessel remodeling. We have recently reported that serum podocalyxin is significantly increased in preeclampsia at disease presentation. In this study we investigated whether serum podocalyxin is altered prior to clinical presentation of preeclampsia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2018.09.009DOI Listing
November 2018
2 Reads

Placental characteristics in monochorionic twins with selective intrauterine growth restriction in relation to the umbilical artery Doppler classification.

Placenta 2018 Nov 18;71:1-5. Epub 2018 Sep 18.

Division of Neonatology, Department of Pediatrics, Leiden University Medical Center, the Netherlands.

Introduction: The objective of this study was to evaluate the placental characteristics of monochorionic twin pregnancies with selective intrauterine growth restriction (sIUGR) classified according to the Gratacós classification based on umbilical artery Doppler measurements.

Methods: All consecutive placentas from monochorionic twin pregnancies with sIUGR, (defined as a birthweight discordance > 25% and/or an estimated fetal weight in one twin <10th centile) examined between May 2002 and February 2018 were included in the study. Each placenta was injected with colored dye to study the angioarchitecture. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2018.09.006DOI Listing
November 2018
1 Read

Placenta Imaging Workshop 2018 report: Multiscale and multimodal approaches.

Placenta 2018 Oct 31. Epub 2018 Oct 31.

Dept. of Medical Physics and Biomedical Engineering, University College London, UK; King's College London, UK.

The Centre for Medical Image Computing (CMIC) at University College London (UCL) hosted a two-day workshop on placenta imaging on April 12th and 13th 2018. The workshop consisted of 10 invited talks, 3 contributed talks, a poster session, a public interaction session and a panel discussion about the future direction of placental imaging. With approximately 50 placental researchers in attendance, the workshop was a platform for engineers, clinicians and medical experts in the field to network and exchange ideas. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2018.10.010DOI Listing
October 2018
2 Reads

Kurt Benirschke: In Memoriam.

Authors:
Mana M Parast

Placenta 2018 Nov 28;71:iv-vi. Epub 2018 Oct 28.

Department of Pathology, University of California San Diego, La Jolla, CA, 92093, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2018.10.006DOI Listing
November 2018
1 Read

FMS-like tyrosine kinase 1 (FLT1) is a key regulator of fetoplacental endothelial cell migration and angiogenesis.

Placenta 2018 Oct 20;70:7-14. Epub 2018 Aug 20.

Division of Reproductive Sciences, University of Colorado School of Medicine, Aurora, CO, USA; Division of Maternal-Fetal Medicine, University of Colorado School of Medicine, Aurora, CO, USA. Electronic address:

Introduction: Fetoplacental angiogenesis plays a vital role in pregnancy outcome. Vascular endothelial growth factor A (VEGFA) is one major regulator of angiogenesis. It primarily binds to FMS-like tyrosine kinase (FLT1) and kinase insert domain receptor (KDR). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2018.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342273PMC
October 2018
1 Read