4,614 results match your criteria Placenta [Journal]


Spontaneous preterm labour that leads to preterm birth: An update and personal reflection.

Authors:
Ronald F Lamont

Placenta 2019 Mar 25. Epub 2019 Mar 25.

Department of Gynaecology and Obstetrics, University of Southern Denmark, Odense University Hospital, Odense, Denmark, and Division of Surgery, University College London, Northwick Park Institute for Medical Research Campus, London, UK. Electronic address:

Objective: The objective was to provide an update of progress made over time (including personal reflection) of our attempts to reduce the mortality and morbidity associated with spontaneous preterm labour that leads to preterm birth.

Methods: An experienced and evidence based approach was taken to provide an overview of progress made over a generation (∼40 years) in our understanding of spontaneous preterm labour.

Results: It is evident that we have made significant progress in our understanding of the aetiology, the measurement of the burden, the basic science, systems biology and mechanical pathways of the preterm parturition syndrome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2019.03.010DOI Listing

Review: Understanding the role of androgens and placental AR variants: Insight into steroid-dependent fetal-placental growth and development.

Placenta 2019 Mar 19. Epub 2019 Mar 19.

Mater Medical Research Institute, University of Queensland, Brisbane, Australia. Electronic address:

The role of steroids throughout pregnancy and their effect on placental physiology is well established, especially for estrogens, progestogens, and glucocorticoids; however, the role of androgens - particularly within the context of placental physiology - remains largely unexplored. Androgens are often defined as the male sex-steroids and are fundamental for the defeminisation and masculinisation of male fetuses. Therefore, the placenta may adapt to these steroids in a sex-specific manner, with males being more receptive to changes in these steroids concentrations, when compared with females; however, their involvement in female intrauterine development has been investigated in several studies and may suggest females have a level of responsiveness to these steroids. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2019.03.006DOI Listing

Maternal high-fat diet sex-specifically alters placental morphology and transcriptome in rats: Assessment by next-generation sequencing.

Placenta 2019 Mar 12;78:44-53. Epub 2019 Mar 12.

Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan; Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan. Electronic address:

Introduction: Maternal nutrition is an extremely important health issue. We evaluated the impact of maternal high fat diet (HFD) on pregnancy outcomes, elucidated how the rat placenta and fetus respond to diet manipulation based on fetal sex, and identified candidate genes and pathways.

Methods: Rats were fed a normal or HFD diet for 10 weeks before conception and during gestation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2019.03.004DOI Listing
March 2019
1 Read

Expression of the neonatal Fc-receptor in placental-fetal endothelium and in cells of the placental immune system.

Placenta 2019 Mar 28;78:36-43. Epub 2019 Feb 28.

Institute of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria. Electronic address:

Introduction: Starting from the second trimester of pregnancy, passive immunity is provided to the human fetus by transplacental transfer of maternal IgG. IgG transfer depends on the neonatal Fc receptor, FcRn. While FcRn localization in the placental syncytiotrophoblast (STB) has been demonstrated unequivocally, FcRn expression in placental-fetal endothelial cells (pFECs), which are part of the materno-fetal barrier, is still unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2019.02.012DOI Listing

Plasma concentrations of soluble endoglin in the maternal circulation are associated with maternal vascular malperfusion lesions in the placenta of women with preeclampsia.

Placenta 2019 Mar 1;78:29-35. Epub 2019 Mar 1.

Department of Obstetrics, Gynecology and Reproductive Sciences, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, PA, USA; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.

We evaluated the association between plasma soluble endoglin (sENG) and maternal vascular malperfusion (MVM) lesions of the placenta in women with preeclampsia. We measured sENG (sCD105) by ELISA in N = 70 women diagnosed with preeclampsia (median [IQR] GA at sampling = 36.4 [6. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2019.02.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455971PMC

Complement receptor-associated CD163/CD18/CD11c/CD206/CD209 expression profile in chronic histiocytic intervillositis of the placenta.

Placenta 2019 Mar 15;78:23-28. Epub 2019 Feb 15.

Institut für Pathologie, Ev.-Luth. Diakonissenanstalt zu Flensburg, Knuthstr. 1, 24939, Flensburg, Germany.

Introduction: Chronic histiocytic intervillositis of unknown etiology (CIUE) is a non-infectious, most probably immunologic placenta lesion. CIUE is associated with recurrent miscarriage, intrauterine growth restriction and stillbirth. Among the pathologic-anatomic defined placental lesions this entity displays the highest risk of recurrence in following pregnancies (about 67-100%). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2019.02.007DOI Listing

Placental T2* estimated by magnetic resonance imaging and fetal weight estimated by ultrasound in the prediction of birthweight differences in dichorionic twin pairs.

Placenta 2019 Mar 7;78:18-22. Epub 2019 Feb 7.

Department of Obstetrics and Gynecology, Aalborg University Hospital, Reberbansgade 15, 9000, Aalborg, Denmark; Department of Clinical Medicine, Aalborg University Hospital, Sdr. Skovvej 15, 9000, Aalborg, Denmark.

Introduction: Intertwin birthweight (BW) difference is associated with an increased risk of adverse outcome. Ultrasound estimated fetal weight (EFW) is the current method to predict intertwin BW difference, however, the sensitivity is poor. Therefore, new methods are needed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2019.02.005DOI Listing

Nutrient transporter expression in both the placenta and fetal liver are affected by maternal smoking.

Placenta 2019 Mar 25;78:10-17. Epub 2019 Feb 25.

Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK.

Introduction: The placenta controls nutrient transfer between mother and fetus via membrane transporters. Appropriate transplacental passage of nutrients is essential for fetal growth and development. We investigated whether transporter transcript levels in human placenta-liver pairs from first and early second trimester pregnancies exhibit gestational age- or fetal sex-specific profiles and whether these are dysregulated by maternal smoking. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2019.02.010DOI Listing

Sex modifies placental gene expression in response to metabolic and inflammatory stress.

Placenta 2019 Mar 22;78:1-9. Epub 2019 Feb 22.

Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232, USA; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA; Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA. Electronic address:

Introduction: Metabolic stress (e.g., gestational diabetes mellitus (GDM) and obesity) and infections are common during pregnancy, impacting fetal development and the health of offspring. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01434004193004
Publisher Site
http://dx.doi.org/10.1016/j.placenta.2019.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461364PMC
March 2019
2 Reads

The role of maternal T cell and macrophage activation in preterm birth: Cause or consequence?

Placenta 2019 Mar 9. Epub 2019 Mar 9.

Faculty of Medicine, Department of Surgery & Cancer, Imperial College, London, United Kingdom.

The role of the immune system in term (TL) and preterm labor (PTL) is unknown. Despite the fact that globally, PTL remains the most important cause of childhood mortality. Infection, typically of the fetal membranes, termed chorioamnionitis, is the best-understood driver of PTL, but the mechanisms underpinning other causes, including idiopathic and stretch-induced PTL, are unclear, but may well involve activation of the maternal immune system. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2019.03.003DOI Listing
March 2019
4 Reads

The effects of Assisted Reproductive Technologies on genomic imprinting in the placenta.

Placenta 2019 Mar 4. Epub 2019 Mar 4.

Epigenetics Institute, Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Smilow Center for Translational Research, 3400 Civic Center Blvd, Bldg 421, Philadelphia, PA, 19104-6058, USA. Electronic address:

The placenta is a complex and poorly understood organ, which serves as the connection between the mother and the developing fetus. Genomic imprinting, defined as a regulatory process resulting in the expression of a gene in a parent-of-origin-specific manner, plays an important role in fetal development and placental function. Disturbances that occur during the establishment and maintenance of imprinting could compromise the placenta and fetus, and ultimately, offspring health. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2019.02.013DOI Listing

Preliminary evidence of a paternal-maternal genetic conflict on the placenta: Link between imprinting disorder and multi-generational hypertensive disorders.

Placenta 2019 Feb 23. Epub 2019 Feb 23.

Department of Obstetrics and Gynecology, Nara Medical University, Japan.

There has been great research progress on hypertensive disorders in pregnancy (HDP) in the last few decades. Failure of placentation, especially a lack of uterine spiral artery remodeling, is the main pathological finding of HDP. Currently, members of the vascular endothelial growth factor family are used as markers for the early prediction of onset of HDP. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2019.02.009DOI Listing
February 2019
1 Read

Expression of endothelin type B receptors in uterine artery smooth muscle cells from pregnant Guinea pigs.

Placenta 2019 Feb 22;77:8-15. Epub 2019 Jan 22.

University of Copenhagen, Faculty of Health & Medical Sciences, Experimental Pharmacology and Toxicology, Section of Experimental Animal Models, Department of Veterinary and Animal Sciences, Ridebanevej 9 - 1st Floor, DK-1870, Frederiksberg C, Denmark.

Introduction: It is well established that upregulation of endothelin type B (ET) receptors in vascular smooth muscle cells plays a role in pathophysiological artery remodeling as response to ischemia and atherosclerosis. This study aimed to investigate the ET receptors function and localization under normal physiological remodeling. Specifically, in the guinea pig uterine arteries during pregnancy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2019.01.015DOI Listing
February 2019
2 Reads

Proteomic identification of predictive biomarkers for malignant transformation in complete hydatidiform moles.

Placenta 2019 Feb 5;77:58-64. Epub 2019 Feb 5.

Placental Related Disease Research Unit, Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Thailand. Electronic address:

Introduction: Protein expression in cells are associated with oncogenesis. This study aims to explore proteomic profiles and discover potential biomarkers that can predict malignant transformation of hydatidiform mole.

Methods: Retrospective analysis was done in 14 cases of remission hydatidiform mole and 14 cases of hydatidiform mole who later developed malignancy (GTN group). Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01434004183109
Publisher Site
http://dx.doi.org/10.1016/j.placenta.2019.02.004DOI Listing
February 2019
8 Reads

A synoptic framework and future directions for placental pathology reporting.

Placenta 2019 Feb 11;77:46-57. Epub 2019 Jan 11.

Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Canada; Interdisciplinary School of Health Sciences, Faculty of Health Sciences, University of Ottawa, Ottawa, Canada. Electronic address:

Placental pathology is a key modality for determining placental health during pregnancy, especially in the event of adverse pregnancy outcomes. However, issues with standardization in placental diagnosis, reporting practices and clinical translation prevent this modality from being used to its full potential. This article will highlight these standardization issues and summarize ongoing work in this field to overcome them. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2019.01.009DOI Listing
February 2019

Non-invasive assessment of placental perfusion in vivo using arterial spin labeling (ASL) MRI: A preclinical study in rats.

Placenta 2019 Feb 5;77:39-45. Epub 2019 Feb 5.

INSERM, U970, Sorbonne Paris Cite, Paris Cardiovascular Research Center - PARCC, Paris, France; EA 7328 FETUS, Université Paris Descartes, France; Lumiere Project, France; Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, France; Assistance Publique-Hôpitaux de Paris, Hôpital Louis Mourier, Paris, France.

Introduction: Non-invasive assessment of placental perfusion is of great interest to characterize placental function in clinical practice. This article proposes a strictly non-invasive MRI technique using ASL to quantify placental blood flow in vivo. The aim of this study was to develop a fMRI tool to quantify placental blood flow (PBF) in rat, by using arterial spin labeling (ASL) MRI at 4. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01434004183008
Publisher Site
http://dx.doi.org/10.1016/j.placenta.2019.01.019DOI Listing
February 2019
1 Read

CD34 immunostain increases the sensitivity of placental diagnosis of fetal vascular malperfusion in stillbirth.

Placenta 2019 Feb 4;77:30-38. Epub 2019 Feb 4.

Division of Pathology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA. Electronic address:

Introduction: Postmortem regressive placental changes of stillbirth may obscure the pre-existing placental histomorphology. The objective is to find out whether the use of CD34 immunostain can increase the sensitivity of placental examination in the diagnosis of fetal vascular malperfusion (FVM).

Methods: Twenty six independent clinical and 46 placental variables of 46 placentas from stillbirths were statistically compared to those of 92 placentas from livebirths. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2019.02.001DOI Listing
February 2019
1 Read

Prostaglandin F stimulates adhesion, migration, invasion and proliferation of the human trophoblast cell line HTR-8/SVneo.

Placenta 2019 Feb 24;77:19-29. Epub 2019 Jan 24.

Institute of Animal Reproduction and Food Research, The Polish Academy of Sciences, Olsztyn, Poland. Electronic address:

Introduction: The amount of prostaglandin F (PGF) in the uterine lumen increases during the window of implantation in many mammals, including humans. We hypothesized that PGF regulates processes related to human embryo implantation.

Methods: The effect of PGF was studied using an in vitro model of human extravillous trophoblast (EVT) cell line (HTR-8/SVneo). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2019.01.020DOI Listing
February 2019

A simple and robust fluorescent labeling method to quantify trophoblast fusion.

Placenta 2019 Feb 24;77:16-18. Epub 2019 Jan 24.

Department of Biochemistry, Duke University Medical Center, Durham, NC, USA; Department of Neurobiology, Duke University Medical Center, Durham, NC, USA. Electronic address:

Trophoblast fusion into syncytiotrophoblasts is a specialized yet enigmatic cellular process, which is essential for placental development and function. To facilitate mechanistic understanding of this critical process, here we re-purposed a widely used fluorescent membrane potential dye, Di-8-ANEPPS, to stably label the plasma membrane of live BeWo trophoblast cells. Compared to the methods currently available to quantify trophoblast fusion, our new fluorescent labeling method is simple, economical, robust and versatile, enabling quick and accurate quantification of fusion index in living cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2019.01.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400315PMC
February 2019

Pre-clinical magnetic resonance imaging of retroplacental clear space throughout gestation.

Placenta 2019 Feb 25;77:1-7. Epub 2019 Jan 25.

The Singleton Department of Pediatric Radiology, Texas Children's Hospital, Houston, TX, 77030, USA. Electronic address:

Introduction: Visualization of the retroplacental clear space (RPCS) may provide critical insight into the development of abnormally invasive placenta (AIP). In this pre-clinical study, we characterized the appearance of the RPCS on magnetic resonance imaging (MRI) during the second half of gestation using a liposomal gadolinium contrast agent (liposomal-Gd).

Materials And Methods: Studies were performed in fifteen pregnant C57BL/6 mice at 10, 12, 14, 16, and 18 days of gestation. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01434004183071
Publisher Site
http://dx.doi.org/10.1016/j.placenta.2019.01.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400291PMC
February 2019
17 Reads

Preterm birth rate and dilemma of preterm labor treatment in Asia.

Placenta 2019 Feb 15. Epub 2019 Feb 15.

Department of Obstetrics and Gynecology, College of Medicine, Ewha Womans Univeristy MokDong Hospital, Seoul, South Korea. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2019.01.005DOI Listing
February 2019
11 Reads

Decreased placental glypican expression is associated with human fetal growth restriction.

Placenta 2019 Jan 21;76:6-9. Epub 2018 Dec 21.

Department of Maternal-Fetal Medicine Pregnancy Research Centre, The Royal Women's Hospital, Parkville, 3052, Australia; Department of Obstetrics and Gynaecology, The University of Melbourne, Parkville, 3052, Australia; Department of Medicine, School of Clinical Sciences, Monash University, Clayton, 3168, Australia.

Placental mediated fetal growth restriction (FGR) is a leading cause of perinatal morbidity and mortality. Heparan sulphate proteoglycans (HSPG) are highly expressed in placentae and regulate haemostasis. We hypothesise that altered expression of HSPGs, glypicans (GPC) may contribute to the development of FGR and small-for-gestational-age (SGA). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2018.12.007DOI Listing
January 2019

Increased placental expression of Placental Protein 5 (PP5) / Tissue Factor Pathway Inhibitor-2 (TFPI-2) in women with preeclampsia and HELLP syndrome: Relevance to impaired trophoblast invasion?

Placenta 2019 Jan 19;76:30-39. Epub 2019 Jan 19.

First Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary; Systems Biology of Reproduction Lendulet Research Group, Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary; Maternity Private Department, Kutvolgyi Clinical Block, Semmelweis University, Budapest, Hungary. Electronic address:

Introduction: Placental Protein 5 (PP5)/Tissue Factor Pathway Inhibitor-2 (TFPI-2) is an extracellular matrix-associated protein mainly expressed by the syncytiotrophoblast that may regulate trophoblast invasion. Our aim was to study placental PP5/TFPI-2 expression and its relation to placental pathology in various forms of preeclampsia and HELLP syndrome.

Methods: Placental and maternal blood specimens were collected at the time of delivery from the same women in the following groups: 1) early controls; 2) early preeclampsia; 3) early preeclampsia with HELLP syndrome; 4) late controls; and 5) late preeclampsia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2019.01.011DOI Listing
January 2019
1 Read

Validation studies of a fluorescent method to measure placental glucose transport in mice.

Placenta 2019 Jan 24;76:23-29. Epub 2019 Jan 24.

Robinson Research Institute, The University of Adelaide, Adelaide, South Australia, 5005, Australia; Adelaide Medical School, The University of Adelaide, Adelaide, South Australia, 5005, Australia. Electronic address:

Introduction: Proper placental function is essential for optimal fetal growth in utero. Placental transfer of nutrients to the fetus can be measured using radiolabelled tracers, but non-radioactive methods have potential advantages. This study aimed to develop a fluorescence-based method to measure placental glucose transport in mice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2019.01.014DOI Listing
January 2019
1 Read

Discordance of umbilical coiling index between recipients and donors in twin-twin transfusion syndrome.

Placenta 2019 Jan 18;76:19-22. Epub 2019 Jan 18.

Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Introduction: To compare the intertwin umbilical cord coiling in twin-twin transfusion syndrome (TTTS) before fetoscopic laser treatment and to correlate these with Doppler findings in both twins.

Methods: We performed a prospective study using three-dimensional (3D) ultrasound with color Doppler imaging of the umbilical cord in TTTS. Coiling index was measured as a reciprocal value of one complete vascular coil. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2019.01.013DOI Listing
January 2019

Cellular systems biology identifies dynamic trophoblast populations in early human placentas.

Placenta 2019 Jan 11;76:10-18. Epub 2019 Jan 11.

Department of Physiology, University of Toronto, Toronto, Canada; Department of Obstetrics and Gynaecology, University of Toronto, Toronto, Canada. Electronic address:

Introduction: The human placenta is accessible in early developmental stages and affords a unique opportunity to investigate human organogenesis and the dynamics of transitory cell populations in human placenta development.

Methods: The cell surface proteomic profile of early trophoblast cells of first trimester human placentas was quantified using a high throughput flow cytometry screen of 370 Cluster of Differentiation (CD) antigens. Targeted investigation of candidate trophoblast progenitor populations was done through immunohistochemistry, multi-color flow cytometry, and genome wide expression analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2018.12.012DOI Listing
January 2019
1 Read

Placental villous hypermaturation is associated with improved neonatal outcomes.

Placenta 2019 01 14;76:1-5. Epub 2019 Jan 14.

Department of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, Canada. Electronic address:

Introduction: Accelerated placental maturation is considered a sign of maternal vascular malperfusion, and is often interpreted as an adaptive, compensatory response by the placenta. We tested this interpretation by comparing outcomes in pregnancies with and without accelerated maturation.

Methods: Using data from the National Collaborative Perinatal Project, we categorized preterm placentas (24-34 weeks, inclusive; 2525 births) by whether they showed placental villous hypermaturation (PVH), i. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2019.01.012DOI Listing
January 2019
1 Read

IFPA meeting 2018 workshop report II: Abnormally invasive placenta; inflammation and infection; preeclampsia; gestational trophoblastic disease and drug delivery.

Placenta 2019 Feb 12. Epub 2019 Feb 12.

Mother Infant Research Institute, Tufts Medical Center, Boston, MA, USA. Electronic address:

Workshops are an important part of the IFPA annual meeting as they allow for discussion of specialized topics. At IFPA meeting 2018 there were nine themed workshops, five of which are summarised in this report. These workshops discussed new perspectives and knowledge in the following areas of research: 1) preeclampsia; 2) abnormally invasive placenta; 3) placental infection; 4) gestational trophoblastic disease; 4) drug delivery to treat placental dysfunction. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2019.02.006DOI Listing
February 2019
1 Read

IFPA meeting 2018 workshop report I: Reproduction and placentation among ocean-living species; placental imaging; epigenetics and extracellular vesicles in pregnancy.

Placenta 2019 Feb 10. Epub 2019 Feb 10.

Mother Infant Research Institute, Tufts Medical Center, USA. Electronic address:

Workshops are an important part of the IFPA annual meeting as they allow for discussion of specialized topics. At IFPA meeting 2018 there were nine themed workshops, four of which are summarized in this report. These workshops discussed new knowledge and technological innovations in the following areas of research: 1) viviparity in ocean-living species; 2) placental imaging; 3) epigenetics; and 4) extracellular vesicles in pregnancy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2019.02.003DOI Listing
February 2019

Corrigendum to "Placental pathologic changes and perinatal outcomes in placenta previa" [Placenta 63 C (2018) 15-20].

Placenta 2019 Mar 13;78:54. Epub 2019 Feb 13.

Department of Obstetrics and Gynecology, Inje University Busan Paik Hospital, Busan, South Korea; Paik Institute for Clinical Research, Inje University Busan Paik Hospital, Busan, South Korea. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2018.12.011DOI Listing
March 2019
2 Reads

Progestin therapy to prevent preterm birth: History and effectiveness of current strategies and development of novel approaches.

Placenta 2019 Jan 28. Epub 2019 Jan 28.

Department of Biochemistry, Case Western Reserve University, Cleveland, OH, USA.

In the 1930s the "progestin" hormone produced by the corpus luteum was isolated and found to be a Δ-keto-steroid. It was aptly named progesterone (P4) and in the following 30 years the capacity of P4 and derivatives to prevent preterm birth (PTB) was examined. Outcomes of multiple small studies suggested that progestin prophylaxis beginning at mid-gestation decreases the risk for PTB. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2019.01.018DOI Listing
January 2019
1 Read

The untapped potential of placenta-enriched molecules for diagnostic and therapeutic development.

Placenta 2019 Feb 4. Epub 2019 Feb 4.

Translational Obstetrics Group, Department of Obstetrics and Gynecology, Mercy Hospital for Women, University of Melbourne, Heidelberg, Victoria, 3084, Australia; Mercy Perinatal, Mercy Hospital for Women, Victoria, Australia. Electronic address:

Pregnancy complications such as fetal growth restriction and preeclampsia are diseases with limited biomarkers for prediction, and a complete lack of therapeutic options. We define placenta-enriched molecules as those that are highly expressed in the placenta relative to all other human tissues. Many exist including mRNAs, miRNAs and proteins. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2019.02.002DOI Listing
February 2019
7 Reads

Differential effect of LPS and IL-1β in term placental explants.

Placenta 2019 Jan 22;75:9-15. Epub 2018 Nov 22.

Ste-Justine Hospital Research Centre, Department of Obstetrics and Gynecology, Universite de Montreal, 3175, chemin de la Côte-Sainte-Catherine, Montreal, Quebec, H3T 1C5, Canada; Department of Pharmacology and Physiology, Universite de Montreal, 2900 Edouard-Montpetit Boulevard, Montreal, Quebec, H3T 1J4, Canada; Department of Microbiology, Infectiology, and Immunology, Universite de Montreal, 2900 Edouard-Montpetit Boulevard, Montreal, Quebec, H3T 1J4, Canada. Electronic address:

Introduction: Inflammation is an important cause of placental dysfunction often associated with pregnancy complications. One well-known cause of inflammation is infection, through conserved "pathogen-associated molecular patterns" (PAMPs). Endogenous inducers of inflammation, known as "damage-associated molecular patterns" (DAMPs), have also been associated with pathological pregnancies and could contribute to the observed placental inflammation. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01434004183069
Publisher Site
http://dx.doi.org/10.1016/j.placenta.2018.11.006DOI Listing
January 2019
5 Reads

Histopathological analysis of placentas with congenital cytomegalovirus infection.

Placenta 2019 Jan 4;75:62-67. Epub 2019 Jan 4.

Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe, Japan. Electronic address:

Introduction: Cytomegalovirus (CMV) infection is the most common cause of congenital viral infections in humans. The unusual structure of the placenta plays a pivotal role in CMV transmission from mothers to fetuses. The aim of this study was to evaluate the histopathological findings of placentas with congenital CMV infections. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2019.01.003DOI Listing
January 2019
5 Reads

The Angiotensin II type 1 receptor mediates the effects of low oxygen on early placental angiogenesis.

Placenta 2019 Jan 6;75:54-61. Epub 2018 Dec 6.

School of Biomedical Sciences and Pharmacy, Priority Research Centre for Reproductive Sciences, Hunter Medical Research Institute, University of Newcastle, Newcastle, New South Wales, Australia. Electronic address:

Introduction: Placental development occurs in a low oxygen environment, which stimulates angiogenesis by upregulating vascular endothelial growth factor A (VEGFA), plasminogen activator inhibitor-1 (SERPINE1) and the angiopoietin-2/-1 ratio (ANGPT2/1). At this time, Angiotensin II type 1 receptor (ATR) is highly expressed. We postulated that the early gestation placental oxygen milieu, by stimulating the angiotensin (Ang) II/ATR pathway, increases expression of proliferative/angiogenic factors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2018.12.001DOI Listing
January 2019
4 Reads

FUT8 drives the proliferation and invasion of trophoblastic cells via IGF-1/IGF-1R signaling pathway.

Placenta 2019 Jan 22;75:45-53. Epub 2018 Nov 22.

Department of Biochemistry and Molecular Biology, Dalian Medical University, Liaoning Provincial Core Lab of Glycobiology and Glycoengineering, Dalian, People's Republic of China. Electronic address:

Introduction: Trophoblast proliferation and invasion are essential for embryo implantation and placentation. Protein glycosylation is one of the most common and vital post-translational modifications, regulates protein physical and biochemical properties. FUT8 is the only known fucosyltransferase responsible for catalyzing α1,6-fucosylation in mammals, and α1,6-fucosylated glycoproteins are found to participate in various physiopathological processes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2018.11.005DOI Listing
January 2019
5 Reads
2.710 Impact Factor

Isolated acute funisitis in the absence of acute chorioamnionitis: What does it mean?

Placenta 2019 Jan 5;75:42-44. Epub 2018 Dec 5.

Weill Cornell Medical College, Department of Pathology and Laboratory Medicine, 520 E 70th St, New York, NY, 10065, USA. Electronic address:

Objective: Acute funisitis (AF) is most commonly associated with acute chorioamnionitis (AC) and ascending infection. The significance of cases of AF without associated AC or isolated funisitis (IF) is unknown. Our objective was to evaluate clinical and pathologic features of IF and to determine its significance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2018.12.002DOI Listing
January 2019
1 Read

Analysis of the effects of polyunsaturated fatty acids on transporter expressions using a PCR array: Induction of xCT/SLC7A11 in human placental BeWo cells.

Placenta 2019 Jan 27;75:34-41. Epub 2018 Nov 27.

Laboratory of Clinical Pharmaceutics & Therapeutics, Division of Pharmasciences, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12-jo, Nishi-6-chome, Kita-ku, Sapporo, 060-0812, Japan; Department of Pharmacy, Hokkaido University Hospital, Kita-14-jo, Nishi-5-chome, Kita-ku, Sapporo, 060-8648, Japan. Electronic address:

Objective: Polyunsaturated fatty acids (PUFAs), including arachidonic acid (AA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), are essential for adequate fetal growth. The aim of the present study was to elucidate the effects of PUFAs on the expression and function of placental transporters, which play important roles in placental functions including the supply of nutrients to the fetus, excretion of metabolites, and protection of the fetus from xenobiotics.

Methods: Human placental choriocarcinoma BeWo cells were used as a trophoblast model. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2018.11.010DOI Listing
January 2019
3 Reads

Fetal human leukocyte antigen-C and maternal killer-cell immunoglobulin-like receptors in cases of severe preeclampsia.

Placenta 2019 Jan 22;75:27-33. Epub 2018 Nov 22.

Centre for Immune Regulation and Reproductive Immunology (CIRRI), Department of Clinical Biochemistry, The ReproHealth Research Consortium ZUH, Zealand University Hospital, Department of Clinical Medicine, University of Copenhagen, Denmark. Electronic address:

Introduction: The pathogenesis of preeclampsia may involve inadequate trophoblast invasion caused by excessive inhibition of uterine natural killer cells (uNK) by extravillous trophoblast cells (EVT). This may be the result of a combination of maternal killer-cell immunoglobin-like receptor (KIR) AA genotype and fetal human leukocyte antigen-C2 (HLA-C2) genotype. A few studies have reported a significantly increased frequency of the maternal KIR AA/fetal HLA-C2 combination in cases of preeclampsia compared to controls. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2018.11.008DOI Listing
January 2019
1 Read

SLC11A1 is expressed in the human placenta across multiple gestational ages.

Placenta 2019 Jan 22;75:23-26. Epub 2018 Nov 22.

Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. Electronic address:

The human placenta functions as an innate immune barrier to prevent fetal infection. However, the molecular mechanisms accounting for placental resistance to pathogens are currently poorly understood. The solute carrier family 11 member 1 (SLC11A1) is a divalent cation transporter expressed primarily by macrophages and neutrophils that is essential for controlling infections by intracellular pathogens such as Salmonella, Leishmania and Mycobacteria. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2018.11.009DOI Listing
January 2019
1 Read

Comparative transcriptome analysis of embryo invasion in the mink uterus.

Placenta 2019 Jan 16;75:16-22. Epub 2018 Nov 16.

Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun, China; State Key Laboratory for Molecular Biology of Special Economic Animal and Plant Science, Chinese Academy of Agricultural Sciences, Changchun, China.

Introduction: In mink, as many as 65% of embryos die during gestation. The causes and the mechanisms of embryonic mortality remain unclear. The purpose of our study was to examine global gene expression changes during embryo invasion in mink, and thereby to identify potential signaling pathways involved in implantation failure and early pregnancy loss. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2018.11.004DOI Listing
January 2019
3 Reads
2.710 Impact Factor

Pravastatin improves fetal survival in mice with a partial deficiency of heme oxygenase-1.

Placenta 2019 Jan 14;75:1-8. Epub 2018 Nov 14.

Dept of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Stanford, CA, USA.

Introduction: Statins induce heme oxygenase-1 (HO-1) expression in vitro and in vivo. Low HO-1 expression is associated with pregnancy complications, e.g. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2018.11.001DOI Listing
January 2019
2 Reads

Retraction notice to "Invasion of trophoblast cell lines is inhibited by miR-93 via MMP-2" [YPLAC 53C (2017) 48-53].

Placenta 2018 12;74:62

Laboratory of Clinical Genetics, Huaian Maternity and Child Health Care Hospital of Jiangsu Province, Yangzhou University, Huaian, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2018.11.002DOI Listing
December 2018
2.710 Impact Factor

Corrigendum to "Phthalate metabolites and bisphenol-A in association with circulating angiogenic biomarkers across pregnancy" [Placenta 36 (2015) 699-703].

Placenta 2019 Jan 18;76:54. Epub 2019 Jan 18.

Department of Environmental Health Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109-2029, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2019.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398335PMC
January 2019
1 Read

Determinants and outcomes of preterm births at a tertiary hospital in Ghana.

Placenta 2019 Jan 8. Epub 2019 Jan 8.

Department of Obstetrics and Gynecology, School of Medicine and Dentistry, University of Ghana, Accra, Ghana.

Introduction: Preterm birth remains an important clinical challenge with significant short and long-term complications although its burden in the developing world is not adequately explored. This study determines the incidence, specific determinants and outcomes of preterm birth at a teaching hospital in Ghana.

Methods: Retrospective review of singleton births at Korle-Bu Teaching Hospital (KBTH) in Ghana between 1st January to 31st December, 2015. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2019.01.007DOI Listing
January 2019
3 Reads

Integrated RNA-seq and ChIP-seq analysis reveals a feed-forward loop regulating H3K9ac and key labor drivers in human placenta.

Placenta 2019 Jan 10;76:40-50. Epub 2019 Jan 10.

Department of Obstetrics, Gynecology, and Reproductive Sciences, Division of Maternal-Fetal Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, 08901, USA. Electronic address:

Background: Chromatin alterations are important mediators of gene expression changes. We have recently shown that activated non-canonical NF-κB signaling (RelB/p52) recruits histone acetyltransferase CBP and deacetylase HDAC1 to selectively acetylate H3K9 (H3K9ac) to induce expression of corticotropin-releasing hormone (CRH) and prostaglandin-endoperoxide synthase-2 (PTGS2) in the human placenta. Both of these genes play a role in initiating parturition in human pregnancy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2019.01.010DOI Listing
January 2019
2 Reads

Considerations when processing and interpreting genomics data of the placenta.

Placenta 2019 Jan 7. Epub 2019 Jan 7.

BC Children's Hospital Research Institute, 950 West 28th Ave, Vancouver, BC V5Z 4H4, Canada; Department of Medical Genetics, University of British Columbia, 4500, Oak Street, Vancouver, BC V6H3N1, Canada. Electronic address:

The application of genomic approaches to placental research has opened exciting new avenues to help us understand basic biological properties of the placenta, improve prenatal screening/diagnosis, and measure effects of in utero exposures on child health outcomes. In the last decade, such large-scale genomic data (including epigenomics and transcriptomics) have become more easily accessible to researchers from many disciplines due to the increasing ease of obtaining such data and the rapidly evolving computational tools available for analysis. While the potential of large-scale studies has been widely promoted, less attention has been given to some of the challenges associated with processing and interpreting such data. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01434004183114
Publisher Site
http://dx.doi.org/10.1016/j.placenta.2019.01.006DOI Listing
January 2019
8 Reads

Elevated protease HtrA4 in the maternal circulation of preeclampsia may contribute to endothelial barrier disruption by cleaving key junctional protein VE-cadherin.

Placenta 2019 Jan 2;76:51-53. Epub 2019 Jan 2.

Implantation and Placental Development Laboratory, Centre for Reproductive Health, Hudson Institute of Medical Research, Clayton, VIC, Australia; Department of Molecular and Translational Science, Monash University, Clayton, VIC, Australia; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC, Australia. Electronic address:

Preeclampsia is hallmarked by systemic endothelial dysfunction, including increased endothelial permeability and oedema. Placenta-derived factors in maternal blood contribute to endothelial barrier impairment, but molecular mechanisms are unclear. HtrA4 is a placenta-specific protease that is secreted into the maternal circulation and elevated in early-onset preeclampsia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2019.01.001DOI Listing
January 2019
3 Reads

Maternal exercise and growth restriction in rats alters placental angiogenic factors and blood space area in a sex-specific manner.

Placenta 2018 Dec 15;74:47-54. Epub 2018 Dec 15.

Department of Physiology, The University of Melbourne, Parkville, VIC, 3010, Australia. Electronic address:

Fetal growth and development are dependent on adequate placental nutrient transfer. The surface area of the placental villous network is a key determinant of nutrient exchange, which is regulated by vasculogenic and angiogenic factors. These factors are altered by intrauterine growth restriction (IUGR) and maternal obesity in both the first (F1) and second (F2) generations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2018.12.005DOI Listing
December 2018
2 Reads