91,718 results match your criteria Placenta [Journal]


Peer-assisted learning after onsite, low-dose, high-frequency training and practice on simulators to prevent and treat postpartum hemorrhage and neonatal asphyxia: A pragmatic trial in 12 districts in Uganda.

PLoS One 2018 17;13(12):e0207909. Epub 2018 Dec 17.

Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America.

An urgent need exists to improve and maintain intrapartum skills of providers in sub-Saharan Africa. Peer-assisted learning may address this need, but few rigorous evaluations have been conducted in real-world settings. A pragmatic, cluster-randomized trial in 12 Ugandan districts provided facility-based, team training for prevention and management of postpartum hemorrhage and birth asphyxia at 125 facilities. Read More

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December 2018

Targeting the vascular dysfunction: potential treatments for preeclampsia.

Microcirculation 2018 Dec 16:e12522. Epub 2018 Dec 16.

Departments of Obstetrics and Gynaecology and Medicine, School of Clinical Sciences, The Ritchie Centre, Monash University, Clayton, Victoria, Australia.

Preeclampsia is a pregnancy specific disorder, primarily characterized by new-onset hypertension in combination with a variety of other maternal or fetal signs. The pathophysiological mechanisms underlying the disease are still not entirely clear. Systemic maternal vascular dysfunction underlies the clinical features of preeclampsia. Read More

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December 2018

miRNA-185 regulates retained fetal membranes of cattle by targeting STIM1.

Theriogenology 2018 Nov 27;126:166-171. Epub 2018 Nov 27.

College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing 163319, China. Electronic address:

Retained fetal membranes (RFM) of cows is an important reproductive disturbance, and is related to miRNA-185. Stromal interaction molecule 1 (STIM1), a potential target gene of miRNA-185, could influence placenta release via regulating Ca concentration intracellular. The aim of this study was to explore the mechanism of RFM by investigating the regulatory relationship between miRNA-185 and STIM1 in primary uterine caruncel epithelial (UCE) cells. Read More

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November 2018

Imprinted genes influencing the quality of maternal care.

Front Neuroendocrinol 2018 Dec 13. Epub 2018 Dec 13.

Biomedicine Division, School of Biosciences, Cardiff University, Cardiff, UK, CF10 3AX, UK. Electronic address:

In mammals successful rearing imposes a cost on later reproductive fitness specifically on the mother creating the potential for parental conflict. Loss of function of three imprinted genes in the dam result in deficits in maternal care suggesting that, like maternal nutrients, maternal care is a resource over which the parental genomes are in conflict. However, the induction of maternal care is a complex and highly regulated process. Read More

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December 2018

Vitamin D deficiency influences fatty acid metabolism.

Prostaglandins Leukot Essent Fatty Acids 2019 Jan 29;140:57-63. Epub 2018 Nov 29.

Mother and Child Health, Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth (Deemed to be University), Pune Satara Road, Pune411043, India. Electronic address:

Reports indicate that maternal vitamin D deficiency may be associated with increased inflammation. Long chain polyunsaturated fatty acids (LCPUFAs); omega-3 and omega-6 fatty acids are known to have anti-inflammatory and pro-inflammatory properties respectively. The present study examines the effect of vitamin D deficiency on fatty acid composition and metabolism in a rat model. Read More

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January 2019
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Rapamycin administration during normal and diabetic pregnancy effects the mTOR and angiogenesis signaling in the rat placenta.

J Gynecol Obstet Hum Reprod 2018 Dec 12. Epub 2018 Dec 12.

Department of Histology and Embryology, Medical Faculty, Akdeniz University, 07070, Antalya, Turkey. Electronic address:

Objective: The mammalian target of rapamycin (mTOR) signaling pathway has newly been recommended to be a nutrient sensor in the placenta. It is speculated that mTORC1 may be activated in diabetes, associated with increased placental nutrient availability. Thus, we aimed to investigate the mTOR signaling pathway both in diabetic and non-diabetic placenta and searched for the alterations of angiogenic factors VEGF, VEGFR1 and VEGFR2. Read More

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December 2018
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Biology of preeclampsia: Combined actions of angiogenic factors, their receptors and placental proteins.

Biochim Biophys Acta Mol Basis Dis 2018 Dec 12. Epub 2018 Dec 12.

Division of Cell Biology, Histology and Embryology, Gottfried Schatz Research Center, Medical University of Graz, Graz, Austria. Electronic address:

Although massive efforts have been undertaken to elucidate the etiology of the pregnancy syndrome preeclampsia, its developmental origin remains a mystery. Most efforts of the last decade have focused on biomarkers to predict and/or diagnose preeclampsia, including the anti-angiogenic factor sFlt-1 (soluble fms-like tyrosin kinase-1), the angiogenic factor PGF (placental growth factor) and PP13 (placental protein 13). The origins of these marker proteins are still under debate, and so far their actions have only been describe separate from each other. Read More

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December 2018

Prevalence and risk factors for brucellosis seropositivity in cattle in Nyagatare District, Eastern Province, Rwanda.

J S Afr Vet Assoc 2018 Dec 5;89(0):e1-e8. Epub 2018 Dec 5.

School of Animal Sciences and Veterinary Medicine, University of Rwanda.

A survey involving 120 small-scale dairy farmers was carried out to assess risk factors associated with brucellosis in cattle from selected sectors of Nyagatare District, Rwanda. A sample of cattle from nine selected sectors of Nyagatare was tested for brucellosis using the Rose Bengal Test. Of the respondents, 57. Read More

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December 2018

Calreticulin regulates syncytialization through control of the synthesis and transportation of E-cadherin in BeWo cells.

Endocrinology 2018 Dec 14. Epub 2018 Dec 14.

Department of Obstetrics and Gynecology, Wakayama Medical University.

During placental development, mononuclear cytotrophoblasts differentiate and fuse to syncytiotrophoblasts (STB) to form syncytia, which secrete human chorionic gonadotropin (hCG). Decreased maternal perfusion of the placenta, which leads to placental dysfunction, induces changes in trophoblast syncytialization. Our previous study showed that calreticulin (CRT), a Ca2+-binding molecular chaperone found in the endoplasmic reticulum, is expressed in the human placenta and is involved in regulating extravillous trophoblast invasion, although its role in villous trophoblasts remains unclear. Read More

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December 2018

Self-Assembled GFFYK Peptide Hydrogel Enhances the Therapeutic Efficacy of Mesenchymal Stem Cells in a Mouse Hindlimb Ischemia Model.

Acta Biomater 2018 Dec 11. Epub 2018 Dec 11.

Nankai University School of Medicine, Tianjin 300071, China; The Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, The College of Life Science, Tianjin 300071, China. Electronic address:

Mesenchymal stem cell (MSC) transplantation has emerged as a very promising strategy for the treatments of peripheral artery disease (PAD). However, MSC-based therapies are limited by low cell retention and survival rate in the ischemic zone. Small molecular (SM) hydrogels have shown attractive abilities to enhance the therapeutic effects of human MSCs via promoting their proliferation or maintaining their differentiation potential. Read More

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December 2018
2 Reads

Twin-to-twin transfusion syndrome in dichorionic twin pregnancy: rare but not impossible.

Ultrasound Obstet Gynecol 2018 Dec 14. Epub 2018 Dec 14.

Fetal therapy Unit "U. Nicolini", Vittore Buzzi Children's Hospital, Università di Milano, Milan, Italy.

Twin-to-twin transfusion syndrome (TTTS) is a typical complication of monochorionic (MC) twin pregnancy related to the presence of vascular anastomosis on the surface of the shared placenta . This article is protected by copyright. All rights reserved. Read More

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December 2018

Possible predictive role of cancer/testis antigens in breast ductal carcinoma .

Oncol Lett 2018 Dec 3;16(6):7245-7255. Epub 2018 Oct 3.

Department of Oncology, University of Zagreb School of Medicine, Sisters of Mercy University Hospital Center, University Hospital for Tumors, 10000 Zagreb, Croatia.

Cancer/testis antigens (CTAs) are a large family of tumor-associated antigens expressed in human tumors of different histological origin, but not in normal tissues, with the exception of the testes and placenta. Numerous immunohistochemical studies have reported associations between CTA expression and a negative estrogen receptor (ER) status in breast tumors, and demonstrated that CTAs are frequently expressed in tumors with higher nuclear grade. The expression of CTAs has not been studied as extensively in ductal carcinoma (DCIS) as it has been in invasive breast cancer. Read More

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December 2018

Exploration of the regulation and control mechanisms of miR-145 in trophoblast cell proliferation and invasion.

Exp Ther Med 2018 Dec 23;16(6):5298-5304. Epub 2018 Oct 23.

Department of Obstetrics, Huai'an First People's Hospital, Huai'an, Jiangsu 223300, P.R. China.

Preeclampsia (PE) is the leading cause of maternal and fetal mortality and morbidity. Furthermore, recent studies have reported that miR-145 within the preeclamptic trophoblast debris may cause the high blood pressure via interacting with the maternal endothelium. The aim of the present study was to investigate the functions of miR-145 in PE. Read More

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December 2018

In vitro effect of orexin A on the transcriptomic profile of the endometrium during early pregnancy in pigs.

Anim Reprod Sci 2018 Nov 20. Epub 2018 Nov 20.

Department of Animal Anatomy and Physiology, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, Oczapowskiego 1A, 10-719 Olsztyn-Kortowo, Poland. Electronic address:

Orexin A belongs to the group of hypothalamic-derived peptides that are involved in a number of processes, such as regulation of energy metabolism, control of food intake and regulation of the reproductive system, by influencing the hypothalamic-pituitary-ovarian axis. Orexin A is also present in the endometrium, myometrium and placenta, which indicates that it may function as an important local regulator of the reproductive functions. The aim of this study was to explore the effects of orexin A on global gene expression in the endometrium of pigs during early gestation, on days 15 to 16 of pregnancy (implantation period). Read More

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November 2018

Response to Correspondence: Marginal sinus placenta previa is a different entity in placenta previa: A retrospective study using magnetic resonance imaging.

Taiwan J Obstet Gynecol 2018 Dec;57(6):910

Department of Obstetrics and Gynecology, National Defense Medical College Hospital, Tokorozawa, Saitama, 359-8513, Japan.

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December 2018

Is marginal sinus placenta previa a mild type of placenta previa?

Taiwan J Obstet Gynecol 2018 Dec;57(6):909

Perinatal and Maternal Center of Saitama Medical Center, Jichi Medical University, Saitama, Japan.

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December 2018

Digynic triploidy in a fetus presenting with semilobar holoprosencephaly.

Taiwan J Obstet Gynecol 2018 Dec;57(6):881-884

Department of Medical Research, MacKay Memorial Hospital, Taipei, Taiwan; Department of Bioengineering, Tatung University, Taipei, Taiwan.

Objective: We present digynic triploidy in a fetus with semilobar holoprosencephaly (HPE).

Case Report: A 32-year-old, gravid 1, para 0, woman underwent prenatal ultrasound examination at 12 weeks of gestation, and the ultrasound showed relative macrocephaly, a small non-cystic placenta, and a fetus with absent nasal bone and semilobar HPE. The pregnancy was terminated subsequently, and a 50-g fetus was delivered with a relatively enlarged head and premaxillary agenesis. Read More

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December 2018

A case control study of risk factors and neonatal outcomes of preterm birth.

Taiwan J Obstet Gynecol 2018 Dec;57(6):814-818

Clinical Medical College, Yangzhou University, Yangzho, 225001, Jiangsu, China; Department of Gynecology and Obstetrics, Northern Jiangsu People's Hospital, Yangzhou, 225001, Jiangsu, China. Electronic address:

Objective: The aim is to examine risk factors and neonatal outcomes of preterm birth and to provide basis in preventing preterm birth.

Materials And Methods: we carried out our study on 1328 term controls and 1328 preterm birth cases. By using multivariable logistic regression procedures we estimated odds ratio (OR) of potential preterm birth risk factors. Read More

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December 2018
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The Prenatal Microbiome: A New Player for Human Health.

High Throughput 2018 Dec 11;7(4). Epub 2018 Dec 11.

CEINGE-BiotecnologieAvanzate, via G. Salvatore via G. Salvatore 486, 80145 Naples, Italy.

The last few years have featured an increasing interest in the study of the human microbiome and its correlations with health status. Indeed, technological advances have allowed the study of microbial communities to reach a previously unthinkable sensitivity, showing the presence of microbes also in environments usually considered as sterile. In this scenario, microbial communities have been described in the amniotic fluid, the umbilical blood cord, and the placenta, denying a dogma of reproductive medicine that considers the uterus like a sterile womb. Read More

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December 2018

Morphological evaluation of cervix using MRI at 32 to 36 weeks of gestation: Findings for predicting invasive placenta previa.

Medicine (Baltimore) 2018 Dec;97(49):e13375

Department of Obstetrics, Jinan Maternity and Child Care Hospital, Jinan, China.

This study is to investigate the role of cervical morphology evaluated by magnetic resonance imaging (MRI) in predicting invasive placenta previa (IPP).Totally 105 cases of pregnant women underwent prenatal placental MRI at 32 to 36 weeks of gestation for suspected IPP were included in this study. Cervical morphology (cervical length and placental protrusion) was evaluated independently by 2 radiologists. Read More

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December 2018

Down-regulated expressed protein HMGB3 inhibits proliferation and migration, promotes apoptosis in the placentas of fetal growth restriction.

Int J Biochem Cell Biol 2018 Dec 10. Epub 2018 Dec 10.

Department of Obstetrics and Gynecology, The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University (Nanjing Maternity and Child Health Care Hospital), Nanjing, 210004, China. Electronic address:

Fetal growth restriction (FGR) is one of the major complications of pregnancy, which can lead to serious short-term and long-term diseases. High-mobility group box 3 (HMGB3) has been found to contribute to the development of many cancers. However, the role of HMGB3 in the pathogenesis of FGR is blank. Read More

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December 2018

Intrauterine Inflammation Damages Placental Angiogenesis via Wnt5a-Flt1 Activation.

Inflammation 2018 Dec 12. Epub 2018 Dec 12.

Department of Neonatology, Guangdong Women and Children Hospital, Guang Zhou Medical University, Guangzhou, 510010, Guangdong, China.

Intrauterine inflammation is the main reason for neonatal adverse outcomes and normal placenta perfusion plays an important role in fetal development. However, whether inflammation will affect placental angiogenesis and the underlying mechanism are still poorly understood. To investigate lipopolysaccharide (LPS)-induced intrauterine inflammation on placenta angiogenesis and Wnt5a-Flt1 expression. Read More

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December 2018

Intrauterine sutures in cesarean section for placenta previa: some concerns.

Arch Gynecol Obstet 2018 Dec 12. Epub 2018 Dec 12.

Department of Obstetrics and Gynecology, Jichi Medical University, 3311-1, Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan.

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December 2018

Isolation of villous cytotrophoblasts from second trimester human placentas.

Placenta 2018 Nov 22. Epub 2018 Nov 22.

Robinson Research Institute, University of Adelaide, Adelaide, SA, 5005, Australia; Adelaide Medical School, University of Adelaide, Adelaide, SA, 5000, Australia.

Human placental functional studies are often performed using immortalised trophoblast cells and cell lines established from human choriocarcinomas, which, while practical, may not truly reflect trophoblast function in vivo. Primary trophoblast cultures derived from human placentas following pregnancy termination or delivery are more clinically relevant, but trophoblast isolation protocols are only available for 1st trimester and term placental tissues. Here we report a method for isolation and purification of primary villous cytotrophoblasts from 2nd trimester human placentas, that yields >99% trophoblast purity as shown by immunofluorescence. Read More

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November 2018

Topical anti-inflammatory and anti-oxidative effects of porcine placenta extracts on 2,4-dinitrochlorobenzene-induced contact dermatitis.

BMC Complement Altern Med 2018 Dec 12;18(1):331. Epub 2018 Dec 12.

Department of Biomedical Science and Engineering, Konkuk Institute of Technology, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, South Korea.

Background: The placenta is a reservoir enriched with growth factors, hormones, cytokines and minerals. While several beneficial effects of placenta extracts on wound healing, anti-aging and anti-inflammatory responses have been reported, relatively limited mechanistic exploration has been conducted to date. Here, we provide compelling evidence of anti-inflammatory and anti-oxidative activities of porcine placenta extracts (PPE) against contact dermatitis in vivo. Read More

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December 2018

Rift Valley fever virus induces fetal demise in Sprague-Dawley rats through direct placental infection.

Sci Adv 2018 Dec 5;4(12):eaau9812. Epub 2018 Dec 5.

Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA.

Rift Valley fever virus (RVFV) infections in pregnant livestock cause high rates of fetal demise; miscarriage in pregnant women has also been associated with RVFV infection. To address how RVFV infection during pregnancy causes detrimental effects on the fetus, we developed a pregnant rodent model of RVFV infection. We found that pregnant rats were more susceptible to RVFV-induced death than their nonpregnant counterparts and that RVFV infection resulted in intrauterine fetal death and severe congenital abnormalities, even in pups from infected asymptomatic pregnant rats. Read More

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December 2018

Safety and efficacy of allogenic placental mesenchymal stem cells for treating knee osteoarthritis: a pilot study.

Cytotherapy 2018 Dec 3. Epub 2018 Dec 3.

Cell-based Therapies Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran; Department of Pathology and Cell-based Therapies Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Objective: Knee osteoarthritis (OA) is a common skeletal impairment that can cause many limitations in normal life activities. Stem cell therapy has been studied for decades for its regenerative potency in various diseases. We investigated the safety and efficacy of intra-articular injection of placental mesenchymal stem cells (MSCs) in knee OA healing. Read More

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December 2018

Maternal Oxidative Stress, Placental Morphometry, and Fetal Growth in Diabetic Rats Exposed to Cigarette Smoke.

Reprod Sci 2018 Dec 6:1933719118815589. Epub 2018 Dec 6.

1 Laboratory of Experimental Research on Gynecology and Obstetrics, Botucatu Medical School, Sao Paulo State University (UNESP), Botucatu, São Paulo, Brazil.

The diabetic syndrome affects pregnancy, contributing to placental functional and structural disruptions and impaired fetal development, with many reports indicating tobacco-associated morbidity and perinatal mortality. In our study, an experimental rat model of diabetes and cigarette smoke exposure in pregnant rats was used to determine the impact of the combination of diabetes and exposure to cigarette smoke during pregnancy on maternal oxidative stress biomarkers and placental and fetal development. Diabetes was induced by streptozotocin, and dams were exposed to cigarette smoke by mainstream smoke generated by a mechanical smoking device and delivered into a chamber. Read More

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December 2018

Oxygen regulation of aquaporin-4 in human placenta.

Reprod Biomed Online 2018 Nov 6;37(5):601-612. Epub 2018 Oct 6.

Laboratorio de Biología de la Reproducción, Instituto de Fisiología y Biofísica Bernardo Houssay (IFIBIO)- CONICET- Facultad de Medicina, Universidad de Buenos Aires. Paraguay 2155 (1121) Buenos Aires, Argentina; Cátedra de Biología Celular y Molecular, Departamento de Ciencias Biológicas, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires. Junín 956 (1113) Buenos Aires, Argentina. Electronic address:

Research Question: We recently reported that blocking of placental aquaporins (AQP) abrogates the apoptotic response of the trophoblast. As trophoblast apoptosis is exacerbated in pre-eclampsia, we hypothesized that changes in AQP in these placentae may trigger programmed cell death. We analysed AQP4 expression in pre-eclamptic placentae and its regulation by oxygen tension. Read More

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November 2018

Acute mesenteric venous thrombosis in a pregnant woman at 35 weeks of gestation: a case report and review of the literature.

BMC Pregnancy Childbirth 2018 Dec 11;18(1):487. Epub 2018 Dec 11.

Department of Obstetrics and Gynecology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China.

Background: Mesenteric venous thrombosis (MVT) is an infrequent thrombotic event that can cause devastating intestinal hemorrhagic ischemia. The mortality rate among patients with acute MVT ranges from 20 to 50%. Occurrence of MVT in pregnancy is quite rare. Read More

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December 2018
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Expression of Plet1 controls interstitial migration of murine small intestinal dendritic cells.

Eur J Immunol 2018 Dec 7. Epub 2018 Dec 7.

Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands.

Under homeostatic conditions, dendritic cells (DCs) continuously patrol the intestinal lamina propria. Upon antigen encounter, DCs initiate C-C motif chemokine receptor 7 (CCR7) expression and migrate into lymph nodes to direct T cell activation and differentiation. The mechanistic underpinnings of DC migration from the tissues to lymph nodes have been largely elucidated, contributing greatly to our understanding of DC functionality and intestinal immunity. Read More

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December 2018

Quantitative Proteomics by SWATH-MS Suggest an Association Between Circulating Exosomes and Maternal Metabolic Changes in Gestational Diabetes Mellitus.

Proteomics 2018 Dec 7:e1800164. Epub 2018 Dec 7.

Exosome Biology Laboratory, Centre for Clinical Diagnostics, University of Queensland Centre for Clinical Research, Royal Brisbane and Women's Hospital, The University of Queensland, Brisbane, QLD, 4029, Australia.

Several factors including placental hormones (PH) released from the human placenta have been associated with the development of insulin resistance and gestational diabetes mellitus (GDM). However, circulating levels of PH do not correlate well with maternal insulin sensitivity across gestation, suggesting that other, previously unrecognized, mechanisms may be involved. The levels of circulating exosomes are higher in GDM compared to normal. Read More

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December 2018
3.807 Impact Factor

Silencing H19 regulated proliferation, invasion, and autophagy in the placenta by targeting miR-18a-5p.

J Cell Biochem 2018 Dec 9. Epub 2018 Dec 9.

Department of Obstetrics and Gynecology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.

Fetal growth restriction (FGR) is a serious pregnancy complication associated with increased perinatal mortality and morbidity. It may lead to neurodevelopmental impairment and adulthood onset disorders. Recently, long noncoding RNAs (lncRNAs) were found to be associated with the pathogenesis of FGR. Read More

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December 2018

microRNA-96 protects pancreatic β-cell function by targeting PAK1 in gestational diabetes mellitus.

Biofactors 2018 Nov 8;44(6):539-547. Epub 2018 Dec 8.

Department of Obstetrics and Gynaecology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.

Gestational diabetes mellitus (GDM) is a disease condition in which a woman develops high blood sugar levels during pregnancy, which might be induced by multiple factors. Among those relative factors, microRNA (miRNA) is well-known to be involved in GDM development. In this study, we investigated the role of miRNA in GDM by analyzing miRNA expression profiling in placenta tissues from healthy or GDM pregnancies. Read More

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November 2018

Refractory Severe Thrombocytopenia during Pregnancy: How to Manage.

Rev Bras Ginecol Obstet 2018 Dec 7;40(12):803-807. Epub 2018 Dec 7.

Department of Anaesthesiology, Centro Hospitalar Lisboa Norte, Lisboa, Portugal.

Thrombocytopenia is the most common hemostatic change in pregnancy, but severe thrombocytopenia is rare. One of the causes, immune thrombocytopenic purpura (ITP), is characterized by increased platelet destruction by immunoglobulin G (IgG) antibodies, presenting a high risk of hemorrhage for the patient, but also for the fetus, since antibodies may cross the placenta. We present the case of a 23-year-old pregnant woman with a history of Langerhans cell histiocytosis of the mandible submitted to surgery and chemotherapy when she was 10 years old, with diagnosis of ITP since then. Read More

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December 2018

A potential role for GSK3beta in glucose-driven intrauterine catch-up growth in maternal obesity.

Endocrinology 2018 Dec 10. Epub 2018 Dec 10.

Department of Paediatrics and Adolescent Medicine, University Hospital of Cologne, Cologne, Germany.

Obesity and an unhealthy nutrition are on the rise and affect also women in childbearing age and hence, during pregnancy. Despite normal or even high birth weight the offspring suffers from long term metabolic risks. We hypothesized that fetal growth is disturbed during different intrauterine phases. Read More

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December 2018

Cross-Species Immune Recognition Between Plasmodium vivax Duffy Binding Protein Antibodies and the Plasmodium falciparum Surface Antigen VAR2CSA.

J Infect Dis 2019 Jan;219(1):110-120

School of Public Health, University of Alberta, Edmonton, Canada.

Background: In pregnancy, Plasmodium falciparum parasites express the surface antigen VAR2CSA, which mediates adherence of red blood cells to chondroitin sulfate A (CSA) in the placenta. VAR2CSA antibodies are generally acquired during infection in pregnancy and are associated with protection from placental malaria. We observed previously that men and children in Colombia also had antibodies to VAR2CSA, but the origin of these antibodies was unknown. Read More

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January 2019

Genome Sequences of Zika Virus Strains Recovered from Amniotic Fluid, Placenta, and Fetal Brain of a Microcephaly Patient in Thailand, 2017.

Microbiol Resour Announc 2018 Sep 20;7(11). Epub 2018 Sep 20.

Department of Biomedical Informatics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.

We present here the complete genome sequences of Zika virus strains isolated from aborted fetal tissue (brain and placenta) and amniotic fluid of a microcephaly patient in Thailand in 2017. The virus genomes that were sequenced have an average length of 10,807 nucleotides. Read More

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September 2018

Metformin and insulin treatment prevent placental telomere attrition in boys exposed to maternal diabetes.

PLoS One 2018 11;13(12):e0208533. Epub 2018 Dec 11.

Division of Biomedicine, Cardiff School of Biosciences, Cardiff University, Cardiff, Wales, United Kingdom.

Shortened leukocyte and placental telomeres associated with gestational diabetes mellitus (GDM) suggest this exposure triggers telomere attrition contributing to adverse outcomes. We applied high resolution Single Telomere Length Analysis (STELA) to placenta from GDM pregnancies with different treatment pathways to determine their effectiveness at preventing telomere attrition. Differences in telomere length between control (N = 69), GDM lifestyle intervention (n = 14) and GDM treated with metformin and/or insulin (n = 17) was tested by Analysis of Covariance (ANCOVA) followed by group comparisons using Fisher's least significant difference. Read More

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December 2018

Efavirenz pharmacokinetics during pregnancy and infant washout.

Antivir Ther 2018 Dec 10. Epub 2018 Dec 10.

Departments of Pharmacy and Pharmacology and Toxicology, Radboud University Medical Center, Nijmegen, The Netherlands.

Background: Limited data exist on efavirenz pharmacokinetics in HIV-positive pregnant women and neonatal washout.

Methods: HIV-infected pregnant women receiving 600 mg efavirenz once daily had intensive steady-state 24-hour pharmacokinetics profiles during the second trimester (2T), third trimester (3T) and 6-12 weeks postpartum (PP). Maternal and umbilical cord blood samples were drawn at delivery and neonatal washout pharmacokinetics were determined. Read More

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December 2018

Transgenerational hypocortisolism and behavioral disruption are induced by the antidepressant fluoxetine in male zebrafish .

Proc Natl Acad Sci U S A 2018 Dec 10. Epub 2018 Dec 10.

Department of Biology, University of Ottawa, Ottawa, ON K1N 6N5, Canada;

The global prevalence of depression is high during childbearing. Due to the associated risks to the mother and baby, the selective serotonin reuptake inhibitor fluoxetine (FLX) is often the first line of treatment. Given that FLX readily crosses the placenta, a fetus may be susceptible to the disruptive effects of FLX during this highly plastic stage of development. Read More

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December 2018

Metabolomics for predicting fetal growth restriction: protocol for a systematic review and meta-analysis.

BMJ Open 2018 Dec 6;8(12):e022743. Epub 2018 Dec 6.

Department of Gynaecology and Obstetrics, University Campinas, Sao Paulo, Brazil.

Introduction: Fetal growth restriction (FGR) is a relevant research and clinical concern since it is related to higher risks of adverse outcomes at any period of life. Current predictive tools in pregnancy (clinical factors, ultrasound scan, placenta-related biomarkers) fail to identify the true growth-restricted fetus. However, technologies based on metabolomics have generated interesting findings and seem promising. Read More

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December 2018

Reference genes for accurate normalization of gene expression in wood-decomposing fungi.

Fungal Genet Biol 2018 Dec 5;123:33-40. Epub 2018 Dec 5.

Department of Plant and Microbial Biology, University of Minnesota, Saint Paul, MN, United States. Electronic address:

Wood-decomposing fungi efficiently decompose plant lignocellulose, and there is increasing interest in characterizing and perhaps harnessing the fungal gene regulation strategies that enable wood decomposition. Proper interpretation of these fungal mechanisms relies on accurate quantification of gene expression, demanding reliable internal control genes (ICGs) as references. Commonly used ICGs such as actin, however, fluctuate among wood-decomposing fungi under defined conditions. Read More

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December 2018
2 Reads

Classification of fetal resilience to porcine reproductive and respiratory syndrome (PRRS) based on temporal viral load in late gestation maternal tissues and fetuses.

Virus Res 2018 Dec 5;260:151-162. Epub 2018 Dec 5.

Western College of Veterinary Medicine, University of Saskatchewan, S7N 5B4, Canada. Electronic address:

Although porcine reproductive and respiratory syndrome virus (PRRSV) readily crosses the maternal fetal interface (MFI) in third trimester, fetal resilience varies within litters. The aim of this study was to characterize PRRSV-2 concentration in MFI and fetuses at five time points after experimental inoculation of late gestation gilts and use this information to classify potentially resistant, resilient and susceptible fetuses. The secondary objective was to verify the relationship between PRRS viral load and intrauterine growth retardation (IUGR). Read More

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December 2018

High density placental mesenchymal stromal cells provide neuronal preservation and improve motor function following in utero treatment of ovine myelomeningocele.

J Pediatr Surg 2018 Oct 4. Epub 2018 Oct 4.

Department of Surgery, University of California Davis, Sacramento, CA, USA.

Purpose: The purpose of this study was to determine whether seeding density of placental mesenchymal stromal cells (PMSCs) on extracellular matrix (ECM) during in utero repair of myelomeningocele (MMC) affects motor function and neuronal preservation in the ovine model.

Methods: MMC defects were surgically created in 33 fetuses and repaired following randomization into four treatment groups: ECM only (n = 10), PMSC-ECM (42 K cells/cm) (n = 8), PMSC-ECM (167 K cells/cm) (n = 7), or PMSC-ECM (250-300 K cells/cm) (n = 8). Motor function was evaluated using the Sheep Locomotor Rating Scale (SLR). Read More

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October 2018
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Folate and choline absorption and uptake: Their role in fetal development.

Biochimie 2018 Dec 6;158:10-19. Epub 2018 Dec 6.

Institute of Human Nutrition and Dietetics, Poznań University of Life Sciences, Poland.

Scope: In this review, we attempt to assess how choline and folate transporters affect fetal development. We focus on how the expression of these transporters in response to choline and folate intake affects transport effectiveness. We additionally describe allelic variants of the genes encoding these transporters and their phenotypic effects. Read More

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December 2018

Aspirin pre-treatment modulates ozone-induced fetal growth restriction and alterations in uterine blood flow in rats.

Reprod Toxicol 2018 Dec 5;83:63-72. Epub 2018 Dec 5.

Environmental Public Health Division, National Health & Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA.

Prenatal exposure to ozone has been linked to low birth weight in people and fetal growth restriction in rats. Clinical recommendations suggest use of low dose aspirin to lower risk of preeclampsia and intrauterine growth restriction in high-risk pregnancies, yet its utility in mitigating the postnatal effects of gestational ozone exposure is unknown. The present study investigated the possibility of low dose aspirin to mitigate the effects of ozone exposure during pregnancy. Read More

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December 2018

Reduced methylation downregulates CD39/ENTPD1 and ZDHHC14 to suppress trophoblast cell proliferation and invasion: Implications in preeclampsia.

Pregnancy Hypertens 2018 Oct 24;14:59-67. Epub 2018 Mar 24.

Obstetrics Department, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China. Electronic address:

Preeclampsia (PE) is a pregnancy-specific syndrome affecting up to 8% of pregnancies worldwide. While PE is a leading cause of maternal and neonatal mortality and morbidity, the pathophysiology of PE is unclear to date. Here, we have verified that dysregulation of CD39/ectonucleoside triphosphate diphosphohydrolase-1 (ENTPD1) and zinc finger DHHC-type containing 14 (ZDHHC14) via DNA methylation plays a vital role in late-onset PE pathology. Read More

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October 2018

Hydrogen peroxide-mediated oxidative stress induces inflammasome activation in term human placental explants.

Pregnancy Hypertens 2018 Oct 27;14:29-36. Epub 2018 Jul 27.

Department of Gynaecology and Obstetrics, Medical School, Botucatu Sao Paulo State University (Unesp), 18618-970 Sao Paulo, Brazil.

Background: The placenta is a multifunctional organ that can suffer with imbalances between pro- and antioxidant molecules, contributing for inflammatory imbalance. The inflammation generated by oxidative stress may induce inflammasome activation, an essential complex for pro-inflammatory cytokine production.

Objective: The aim of this study was to evaluate whether hydrogen peroxide (HO) mediated oxidative stress induces inflammasome activation on placental explants. Read More

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October 2018

Aspirin use during pregnancy and hypoxia-related placental pathology.

Pregnancy Hypertens 2018 Oct 30;14:177-188. Epub 2018 Jul 30.

Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:

Objective: Aspirin has been shown to prevent preeclampsia. But the mechanisms remain unclear despite that improved placental circulation is considered as an underlying contributor. Our aim was to examine the hypoxia-related morphological and histopathological placental measures in relation to aspirin use during pregnancy. Read More

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October 2018
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