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    Atypical Pityriasis Rosea with Unilateral Presentation.
    J Clin Diagn Res 2016 Dec 1;10(12):WD01-WD02. Epub 2016 Dec 1.
    Student, Department of Nursing, Student Research Committee, School of Nursing and Midwifery, Iran University of Medical Science , Tehran, Iran .
    Pityriasis Rosea (PR) is a common skin disease and characterized by generalized scaly eruptions typically on the trunk and proximal extremities. Atypical presentations of PR are common and can be a diagnostic challenge for clinicians. Here we present a case of a 26-year-old female who presented with a sudden onset of several asymptomatic, erythematous and scaly plaques on her trunk. Read More

    [Paraviral exanthems].
    Hautarzt 2017 Feb 13. Epub 2017 Feb 13.
    Department of Dermatology, Godavari Foundation Medical College and Research Center, DUPMCJ, Nashik, Indien.
    Paraviral exanthems are distinct skin diseases due to infections with different viruses. Although no virus has been identified so far in some exanthems, the main age of manifestation, the clinical course of the exanthem, and the extracutaneous symptoms are suggestive for a viral genesis. While many viral infections are a direct result of the infection, paraviral exanthems reflect the response of the immune system to the infectious pathogens. Read More

    Higher Expression of Toll-like Receptors 3, 7, 8, and 9 in Pityriasis Rosea.
    J Pathol Transl Med 2017 Feb 13. Epub 2017 Feb 13.
    Department of Molecular Genetics, National Research Center (NRC), Cairo University, Cairo, Egypt.
    Background: Pityriasis rosea (PR) is a common papulosquamous skin disease in which an infective agent may be implicated. Toll-like receptors (TLRs) play an important role in immune responses and in the pathophysiology of inflammatory skin diseases. Our aim was to determine the possible roles of TLRs 3, 7, 8, and 9 in the pathogenesis of PR. Read More

    Gestational Pityriasis Rosea: Suggestions for Approaching Affected Pregnant Women.
    Acta Dermatovenerol Croat 2016 Dec;24(4):312-313
    Efstathia Pasmatzi, MD, Department of Dermatology, School of Medicine, University of Patras, 26504 Rio-Patras, Greece;
    Dear Editor, Pityriasis rosea is a common, acute, and self-limiting dermatosis, which is associated with the endogenous systemic reactivation of human herpesvirus (HHV)-6 and/or HHV-7 (1). It predominantly affects individuals of both sexes in their second or third decade of life and is clinically characterized by the occurrence of an initial erythematosquamous plaque followed by the appearance of disseminated similar but smaller lesions one or two weeks later. Several patients develop systemic symptoms such as nausea, anorexia, malaise, headache, fever, arthralgia, and lymphadenopathy that may precede or accompany the eruption; the latter follows the cleavage lines of the trunk creating the configuration of a Christmas tree and spontaneously resolves within 4 to 8 weeks. Read More

    Is There a Link between Human Herpesvirus Infection and Toll-like Receptors in the Pathogenesis of Pityriasis Rosea? A Case-control Study.
    Acta Dermatovenerol Croat 2016 Dec;24(4):282-287
    Corresponding author: Rania Abdel Hay, MD, 13th Abrag Othman, Kournish el Maadi, Cairo 11431, Egypt;
    Human herpesvirus (HHV) 6 and 7 are involved in the pathogenesis of pityriasis rosea (PR). Our aim was to evaluate the role of the innate immune response in PR through the detection of Toll-like receptors (TLR) 2, 3, 4, 7, 8, and 9 expression in the skin of affected patients and to detect the possibility of being induced by HHV-6 and/or HHV-7 viral coexistence in these patients. Twenty-four patients with PR and 24 healthy controls were included in this case-control study. Read More

    Concurrent pityriasis rosea and Bell's palsy.
    BMJ Case Rep 2017 Jan 23;2017. Epub 2017 Jan 23.
    Department of Dermatology, Saint Louis University, Saint Louis, Missouri, USA.
    Pityriasis rosea is a dermatological disease with a well-documented clinical appearance, but less is known about causes and treatment. Bell's palsy is a neurological condition leading to acute idiopathic hemifacial paralysis. Recent studies indicate that human herpesvirus (HHV) 6-7 reactivation may be a contributing factor to both conditions. Read More

    Pityriasis rosea: a natural history of pediatric cases in theCentral Anatolia Region of Turkey.
    Turk J Med Sci 2016 Dec 20;46(6):1740-1742. Epub 2016 Dec 20.
    Department of Infectious Diseases and Clinical Microbiology, Bolu İzzet Baysal State Hospital, Bolu, Turkey.
    Background/aim: This study aimed to evaluate the demographic, clinical, and epidemiological features of pityriasis rosea (PR) in a cohort of 46 children in Yozgat, a city in the Central Anatolia Region of Turkey.

    Materials And Methods: Forty-six children with PR were monitored at regular intervals (1, 2, 4, and 12 weeks) for 3 months from the time of diagnosis. A complete evaluation of the patient was performed at each visit. Read More

    The role of interleukin-22 in pityriasis rosea.
    Clin Exp Dermatol 2017 Jan 11;42(1):30-35. Epub 2016 Nov 11.
    Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
    Background: Pityriasis rosea (PR) is an exanthematous disease related to reactivation of human herpes virus (HHV) types 6 and 7. The pathogenesis and cytokine profile of PR are still poorly understood.There is a large amount of evidence indicating a viral aetiology for PR. Read More

    c-CBL E3 Ubiquitin Ligase Expression Increases Across the Spectrum of Benign and Malignant T-Cell Skin Diseases.
    Am J Dermatopathol 2016 Oct 31. Epub 2016 Oct 31.
    *Department of Dermatology, University of Wisconsin, Madison, WI; and †Department of Dermatology, William S. Middleton VA Medical Center, Madison, WI.
    Prolonged survival of lesional T cells plays a central role in the pathogenesis of T-cell-mediated dermatoses. We have recently shown that the ubiquitin ligase c-CBL is highly expressed in cutaneous T-cell lymphoma (CTCL) and that its knockdown increases activation-induced cell death, a key pathway for T-cell apoptosis. Here, we extend our work on c-CBL expression in malignant T cells to their nonneoplastic counterparts in benign inflammatory dermatoses. Read More

    Cutaneous metastasis of inflammatory breast carcinoma mimicking an erythema annulare centrifugum: a sign of locally recurrent cancer.
    Clin Exp Dermatol 2016 Dec 20;41(8):906-910. Epub 2016 Oct 20.
    Department of Oncology, Hospital Casa de Salud, Valencia, Spain.
    Erythema annulare centrifugum (EAC) is a clinical reaction pattern that includes lupus erythematosus, spongiotic dermatitis (particularly pityriasis rosea), pseudolymphoma and cutaneous B-cell lymphoma. However, it can be the result of cutaneous metastasis by an internal carcinoma. We present the case of a 38-year-old woman with bilateral inflammatory breast cancer following multimodal therapy. Read More

    A position statement on the management of patients with pityriasis rosea.
    J Eur Acad Dermatol Venereol 2016 Oct 13;30(10):1670-1681. Epub 2016 Jul 13.
    Histologische Diagnostik, Department of Dermatology, University Hospital Zürich, Zurich, Switzerland.
    Many clinical trials have been conducted on the treatment of pityriasis rosea (PR). Our aim was to establish a position statement for the management of adults with PR based on the best available evidence. We searched PubMed for all reports on randomized controlled trials for the treatment of PR published in the past 30 years. Read More

    Pityriasis rosea in pregnancy: report of a spousal occurrence and craniosynostosis in the healthy newborn.
    Dermatol Pract Concept 2016 Jul 31;6(3):39-46. Epub 2016 Jul 31.
    Department of Dermatology, University of California San Diego, La Jolla, CA, USA.
    Background: Pityriasis rosea is a papulosquamous disease. It may occur during pregnancy; in this setting, it has occasionally been associated with adverse outcomes.

    Purpose: A woman who developed pityriasis rosea at the beginning of her eighth week of gestation is described. Read More

    Dermoscopy in General Dermatology: A Practical Overview.
    Dermatol Ther (Heidelb) 2016 Dec 9;6(4):471-507. Epub 2016 Sep 9.
    Department of Experimental and Clinical Medicine, Institute of Dermatology, University of Udine, Udine, Italy.
    Over the last few years, dermoscopy has been shown to be a useful tool in assisting the noninvasive diagnosis of various general dermatological disorders. In this article, we sought to provide an up-to-date practical overview on the use of dermoscopy in general dermatology by analysing the dermoscopic differential diagnosis of relatively common dermatological disorders grouped according to their clinical presentation, i.e. Read More

    Atypical pityriasis rosea: clinical evaluation of 27 patients.
    Cutan Ocul Toxicol 2016 Sep 26:1-6. Epub 2016 Sep 26.
    b Yildirim Beyazit University, Medical Faculty , Department of Dermatology , Ankara , Turkey.
    Background: Pityriasis rosea (PR) is a common, acute, self-limiting inflammatory skin disease. It can easily be recognized with its typical clinical presentation. However, unusual clinic presentations can cause difficulty in diagnosis. Read More

    Anesthetic Considerations for Neuraxial Anesthesia in Pregnant Patients With Pityriasis Rosea With Skin Lesions Covering the Lumbar Spine.
    A A Case Rep 2016 Oct;7(8):165-168
    From Oregon Health & Science University, Portland, Oregon.
    Pityriasis rosea (PR) is an acute exanthematous skin disease that is likely due to reactivation of human herpesviruses (HHVs) 6b and 7. In contrast to herpes simplex and zoster (alphaherpesviruses), HHV-6b and -7 (betaherpesviruses) are not found predominantly in skin lesions. This difference in virion location may decrease the possibility of causing central nervous system infection through skin contamination, but the risk for hematogenous spread likely remains the same. Read More

    Pityriasis Rosea: An Update on Etiopathogenesis and Management of Difficult Aspects.
    Indian J Dermatol 2016 Jul-Aug;61(4):375-84
    Maulana Azad Medical College, New Delhi, India.
    Pityriasis rosea (PR) is a benign papulosquamous disorder seen commonly in clinical practice. Despite its prevalence and benign nature, there are still times when this common disorder presents in an uncommon way or course posing diagnostic or management problems for the treating physician. The etiopathogenesis of PR has always been a dilemma, and extensive research is going on to elicit the exact cause. Read More

    Clinicopathological Study of Non-Infectious Erythaematous Papulosquamous Skin Diseases.
    J Clin Diagn Res 2016 Jun 1;10(6):EC19-22. Epub 2016 Jun 1.
    Professor and Head, Department of Pathology, A J Institute of Medical Sciences , Kuntikana, Mangalore, Karnataka, India .
    Introduction: Papulosquamous diseases are characterized by scaly papules and plaques with similar clinical picture which amounts to confusion and hence, a definitive histopathological diagnosis goes a long way in treatment of such diseases.

    Aim: The aim of the study was to study the histomorphology of non-infectious, erythaematous, papulosquamous lesions of skin with clinicopathological correlation.

    Materials And Methods: Skin biopsies from 150 clinically diagnosed/suspected non-infectious erythaematous, papulosquamous skin diseases were received in the Department of Pathology. Read More

    A Herald Patch Almost Encircling the Trunk-Extreme Pityriasis Rosea Gigantea in a Young Child.
    Pediatr Dermatol 2016 Sep 11;33(5):e286-7. Epub 2016 Jul 11.
    JC School of Public Health, Chinese University of Hong Kong and Prince of Wales Hospital, Shatin, Hong Kong, China.
    An 18-month-old girl presented with pityriasis rosea gigantea. The herald patch encircled almost the entire trunk. The distribution of lesions on the trunk and proximal aspects of the limbs, the collarette scaling, the orientation of some lesions along the skin crease lines, and biopsy findings substantiated the diagnosis. Read More

    Inflammatory and glandular skin disease in pregnancy.
    Clin Dermatol 2016 May-Jun;34(3):335-43. Epub 2016 Feb 11.
    Department of Dermatology, Warren Alpert Medical School of Brown University, Providence, Rhode Island; Department of Dermatology, Rhode Island Hospital, Providence, Rhode Island.
    A switch from cell-mediated to humoral immunity (helper T 1 [Th1] to helper T 2 [Th2] shift) during gestation plays a key role in placental immune tolerance. As a result, skin diseases that are Th2 mediated often worsen, whereas skin diseases that are Th1 mediated often improve during gestation. Also, due to fluctuations in glandular activity, skin diseases involving sebaceous and eccrine glands may flare, whereas those involving apocrine glands may improve during pregnancy. Read More

    Red Cell Distribution Width and Mean Platelet Volume in Patients With Pityriasis Rosea.
    J Clin Med Res 2016 Jun 25;8(6):445-8. Epub 2016 May 25.
    Department of Statistics, Ondokuz Mayis University School of Medicine Samsun, Turkey.
    Background: Pityriasis rosea (PR) is an inflammatory skin disorder of unknown etiology. However, it is suggested to be related with the reactivation of human herpes virus 7 (HHV-7) and/or HHV-6. It is sometimes diffucult to distinguish PR from PR-like drug eruptions and other inflammatory disorders, so we need new parameters which are cheap and easy in determining PR. Read More

    Acyclovir is not effective in pityriasis rosea: Results of a randomized, triple-blind, placebo-controlled trial.
    Indian J Dermatol Venereol Leprol 2016 Sep-Oct;82(5):505-9
    Department of Community Medicine, Government Medical College, Kannauj, Uttar Pradesh, India.
    Background: Acyclovir is considered to be an effective treatment for pityriasis rosea but randomized, blinded, placebo-controlled trials have not been performed.

    Aims: To test the efficacy of acyclovir in pityriasis rosea in a randomized, triple-blind, placebo-controlled trial.

    Methods: Twenty seven patients with pityriasis rosea were randomly allocated to receive placebo (n = 13) or acyclovir (800 mg five times daily for one week) (n = 14). Read More

    Paraviral exanthems.
    Expert Rev Anti Infect Ther 2016 Jun;14(6):601-11
    c School of Public Health and Primary Care , The Chinese University of Hong Kong and Prince of Wales Hospital , Shatin , Hong Kong.
    Introduction: Paraviral exanthems are skin diseases suspected to be caused by viruses, with a single virus-exanthem relationship not universally accepted. Although most paraviral exanthems are self-remitting, accurate diagnoses are important as some patients might develop complications. Some of the differential diagnoses might cause serious complications, and some paraviral exanthems might lead to complications for at-risk groups such as pregnant women. Read More

    Pityriasis Rosea, Gianotti-Crosti Syndrome, Asymmetric Periflexural Exanthem, Papular-Purpuric Gloves and Socks Syndrome, Eruptive Pseudoangiomatosis, and Eruptive Hypomelanosis: Do Their Epidemiological Data Substantiate Infectious Etiologies?
    Infect Dis Rep 2016 Mar 21;8(1):6418. Epub 2016 Mar 21.
    JC School of Public Health and Primary Care, The Chinese University of Hong Kong and Prince of Wales Hospital , Shatin, Hong Kong.
    Many clinical and laboratory-based studies have been reported for skin rashes which may be due to viral infections, namely pityriasis rosea (PR), Gianotti-Crosti syndrome (GCS), asymmetric periflexural exanthem/unilateral laterothoracic exanthem (APE/ULE), papular-purpuric gloves and socks syndrome (PPGSS), and eruptive pseudo-angiomatosis (EP). Eruptive hypomelanosis (EH) is a newly discovered paraviral rash. Novel tools are now available to investigate the epidemiology of these rashes. Read More

    Pityriasis Rosea: A Comprehensive Classification.
    Dermatology 2016 21;232(4):431-7. Epub 2016 Apr 21.
    DISSAL, Department of Dermatology, IRCCS AOU San Martino-IST, University of Genoa, Genoa, Italy.
    Pityriasis rosea (PR) is an acute, self-limiting exanthematous disease associated with the endogenous systemic reactivation of human herpesvirus (HHV)-6 and/or HHV-7. The disease typically begins with a single, erythematous plaque followed by a secondary eruption with lesions on the cleavage lines of the trunk (configuration of a 'Christmas tree'). The duration may vary from 2 weeks to a few months. Read More

    Seasonal variations in dermatologic and dermatopathologic diagnoses: a retrospective 15-year analysis of dermatopathologic data.
    Int J Dermatol 2016 Oct 7;55(10):1115-8. Epub 2016 Apr 7.
    Temple University School of Medicine, Philadelphia, PA, USA.
    Background: Certain dermatologic conditions are known to show seasonal variations in frequency, the reasons for which are unclear but in some cases may be attributable to changes in ambient weather conditions.

    Objectives: The current study was conducted to determine whether seasonal trends might exist for dermatologic conditions including erythema multiforme, guttate psoriasis, erythema dyschromicum perstans (ashy dermatosis), pityriasis lichenoides, and pityriasis rosea.

    Methods: Data were derived from a 15-year retrospective review of electronic records from a large dermatopathology laboratory located in the mid-Atlantic region of the USA. Read More

    Sex differences in the incidence of skin and skin-related diseases in Olmsted County, Minnesota, United States, and a comparison with other rates published worldwide.
    Int J Dermatol 2016 Sep 24;55(9):939-55. Epub 2016 Mar 24.
    Division of Clinical Dermatology, Mayo Clinic, Rochester, MN, USA.
    Many skin and skin-related diseases affect the sexes unequally, with attendant implications for public health and resource allocation. To evaluate better the incidence of skin and skin-related diseases affecting males vs. females, we reviewed published population-based epidemiology studies of skin disorders performed utilizing Rochester Epidemiology Project data. Read More

    The Oxidant and Antioxidant Status in Pityriasis Rosea.
    Indian J Dermatol 2016 Jan-Feb;61(1):118
    Department of Biochemistry, Atatürk Training and Research Hospital, Ankara, Turkey.
    Background: Pityriasis rosea (PR) is usually an asymptomatic and self-limiting papulosquamous skin disease with acute onset. The etiology has not been clarified yet. Recently, increased oxidative stress was found to play a role in etiopathogenesis of multiple cutaneous diseases with T cell-mediated immune response. Read More

    Leprosy in the Bible.
    Clin Dermatol 2016 Jan-Feb;34(1):3-7. Epub 2015 Nov 17.
    Domestic and Specialized Medicine Centre "Dilmed", ul. Bohaterów Monte Cassino 3, 40-231 Katowice, Poland. Electronic address:
    For many years, the biblical term tzaraat has referred to leprosy. In fact, the disease or diseases described under this name have no relationship to leprosy, as it was known in the Middle Ages or today; moreover, the term referred not only to skin disease, but also to the state of the ritual impurity and punishment for the sins. Although the real nature of tzaraat remains unknown, the differential diagnosis might include the following: Psoriasis, seborrheic dermatitis, favus, dermatophyte infections, nummular dermatitis, atopic dermatitis, pityriasis rosea, crusted scabies, syphilis, impetigo, sycosis barbae, alopecia areata, furuncles, scabies, neurodermatitis, scarlet fever, lupus erythematosus, lichen sclerosus et atrophicus, folliculitis decalvans, morphea, sarcoidosis, and lichen planopilaris. Read More

    Terbinafine induced pityriasis rosea-like eruption.
    Indian J Pharmacol 2015 Nov-Dec;47(6):680-1
    Department of Dermatology, Christian Medical College, Ludhiana, Punjab, India.
    Terbinafine is an allylamine antifungal agent which is widely used for the treatment of fungal infections. Cutaneous side effects have been reported in 2% of the patients on terbinafine therapy with many morphological patterns. We report a case of terbinafine induced pityriasis rosea, a very rare side effect of terbinafine. Read More

    A Clinico-Etiological Study of Dermatoses in Pediatric Age Group in Tertiary Health Care Center in South Gujarat Region.
    Indian J Dermatol 2015 Nov-Dec;60(6):635
    Department of Dermatology, Venereology and Leprosy, Government Medical College, Surat, Gujarat, India.
    Background: Dermatologic conditions have different presentation and management in pediatric age group from that in adult; this to be studied separately for statistical and population based analysis.

    Objective: To study the pattern of various dermatoses in infants and children in tertiary health care center in South Gujarat region.

    Materials And Methods: This is a prospective study; various dermatoses were studied in pediatric patients up to 14 years of age attending the Dermatology OPD of New Civil Hospital, Surat, Gujarat over a period of 12 months from June 2009 to June 2010. Read More

    Akathisia with Erythromycin: Induced or precipitated?
    Saudi Pharm J 2015 Oct 27;23(5):541-3. Epub 2015 Feb 27.
    Department of Psychiatry and Drug De-addiction, Post Graduate Institute of Medical Education and Research, Dr Ram Manohar Lohia Hospital, New Delhi, India.
    Objective: A 28-year-old male diagnosed with schizophrenia, maintaining well on Olanzapine, developed akathisia soon after addition of Erythromycin for Pityriasis Rosea. This prompted us to evaluate the relationship of Erythromycin and akathisia.

    Method: We report the case and the literature focusing on akathisia as a possible adverse event of Erythromycin. Read More

    The diagnostic criteria of pityriasis rosea and Gianotti-Crosti syndrome - a protocol to establish diagnostic criteria of skin diseases.
    J R Coll Physicians Edinb 2015 ;45(3):218-25
    A Chuh, The Western and Bonham Surgeries, Hong Kong, Shops 5 and 6, The Imperial Terrace, 356 Queen's Road West, Ground Floor, Hong Kong. Email
    We established and validated diagnostic criteria for pityriasis rosea and Gianotti-Crosti syndrome. In this paper, we compare and contrast both diagnostic criteria to formulate a protocol in establishing diagnostic criteria for other dermatological diseases. The diagnostic criteria are similar in employing clear dividing lines and conjunctions ('and/or') to assure high reliability. Read More

    Pityriasis rosea-like cutaneous eruption as the presenting symptom of Hodgkin lymphoma. Case report and review of the literature.
    J Dermatol Case Rep 2015 Sep 30;9(3):81-4. Epub 2015 Sep 30.
    Mount Sinai Medical Center, Department of Pathology and Laboratory Medicine, Miami Beach, Florida, USA;
    Background: Cutaneous involvement by Hodgkin lymphoma is extremely rare and usually follows extensive involvement of the lymph nodes. Cutaneous manifestations of Hodgkin lymphoma may be divided into specific and non-specific. Generalized pruritus is one of the most common non-specific presentations of Hodgkin lymphoma as is cutaneous granulomas. Read More

    Narrowband UVB phototherapy in pityriasis rosea.
    Indian Dermatol Online J 2015 Sep-Oct;6(5):326-9
    Department of Dermatology, Venereology, and Leprosy, Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India.
    Objective: Pityriasis rosea (PR) is an acute self-limiting disease. Despite vigorous efforts by generations of researchers since nearly 150 years, present treatment modalities for PR are not very gratifying. Ultraviolet radiation has been recommended in PR, although only a few studies validate this proposal. Read More

    Histologic features of secondary syphilis: A multicenter retrospective review.
    J Am Acad Dermatol 2015 Dec 20;73(6):1025-30. Epub 2015 Oct 20.
    State University of New York Downstate Medical Center, Brooklyn, New York; Ackerman Academy of Dermatopathology, New York, New York; Medical University of South Carolina, Charleston, South Carolina.
    Background: Secondary syphilis has a wide spectrum of clinical and histologic manifestations.

    Objective: We sought to determine the frequency of histopathological features characterizing secondary syphilis, and which are most common in specimens displaying few diagnostic findings.

    Methods: In a multicenter, retrospective analysis of biopsy-proven secondary syphilis, cases were subcategorized by the number of histologic characteristics present. Read More

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