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    Atypical presentations of pityriasis rosea: a reply.
    Dermatol Online J 2017 Aug 15;23(8). Epub 2017 Aug 15.
    Department of Dermatology, IRCCS AOU San Martino, Genoa, Italy.
    Pityriasis rosea (PR) may have atypical presentations as regards morphology and distribution of the lesions. Recently, several forms of PR considered atypical for the course of the disease have been described. Differently from the typical PR that resolves within 2-12 weeks, relapsing and persistent PR forms (lasting longer than 12 weeks) have been described in adults and children. Read More

    Geographic tonguelike presentation in a child with pityriasis rosea: Case report and review of oral manifestations of pityriasis rosea.
    Pediatr Dermatol 2018 Feb 13. Epub 2018 Feb 13.
    Division of Dermatology, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
    Oral lesions are rarely reported in patients with pityriasis rosea. We report a case of a 3-year-old boy with clinical evidence of generalized pityriasis rosea who developed asymptomatic oral lesions similar in appearance to geographic tongue. The generalized eruption and tongue lesions resolved simultaneously within 4 weeks. Read More

    Incidence of diseases primarily affecting the skin by age group: population-based epidemiologic study in Olmsted County, Minnesota, and comparison with age-specific incidence rates worldwide.
    Int J Dermatol 2018 Jan 29. Epub 2018 Jan 29.
    Division of Clinical Dermatology, Mayo Clinic, Rochester, MN, USA.
    Understanding the effects of age on the epidemiology of diseases primarily affecting the skin is important to the practice of dermatology, both for proper allocation of resources and for optimal patient-centered care. To fully appreciate the effect that age may have on the population-based calculations of incidence of diseases primarily affecting the skin in Olmsted County, Minnesota, and worldwide, we performed a review of all relevant Rochester Epidemiology Project-published data and compared them to similar reports in the worldwide English literature. Using the Rochester Epidemiology Project, population-based epidemiologic studies have been performed to estimate the incidence of specific skin diseases over the past 50 years. Read More

    Pityriasis Rosea: Diagnosis and Treatment.
    Am Fam Physician 2018 Jan;97(1):38-44
    Emory University School of Medicine, Atlanta, GA, USA.
    Pityriasis rosea is a common self-limiting rash that usually starts with a herald patch on the trunk and progresses along the Langer lines to a generalized rash over the trunk and limbs. The diagnosis is based on clinical and physical examination findings. The herald patch is an erythematous lesion with an elevated border and depressed center. Read More

    Double-blind randomized placebo-controlled trial to evaluate the efficacy and safety of short-course low-dose oral prednisolone in pityriasis rosea.
    J Dermatolog Treat 2018 Feb 1:1-6. Epub 2018 Feb 1.
    g Skin-Aid Clinic , Gurugram , India.
    Purpose: To evaluate the efficacy and safety of short-course low-dose oral prednisolone in symptomatic pityriasis rosea (PR) of onset <5 days and compare it with placebo.

    Material And Methods: Placebo-controlled randomized double-blind study design with the treatment group receiving tapering doses of oral prednisolone over 2 weeks and the control group receiving a placebo. Outcome measures evaluated were subsidence of patient-perceived pruritus, improvement in rash quantified by a specific score, adverse effects and relapse at 12 weeks. Read More

    Occult Hepatitis B Virus Infections (Often with Human Herpesvirus 7 Co-Infection) Detected inPatients: A Pilot Study.
    Indian J Dermatol 2017 Nov-Dec;62(6):598-605
    Infectious Diseases & Immunology Division, CSIR Indian Institute of Chemical Biology, Kolkata, West Bengal, India.
    Background: The etiopathogenesis of(PR), a papulo-squamous skin disease, remains elusive and hypothesized to be caused primarily by human herpesvirus (HHV) 6 or 7 or immune dysfunction.

    Aims: The recent increasing incidences of hepatitis B virus (HBV) infections, including asymptomatic occult HBV infections (OBIs), in a densely populated city in India, prompted us to investigate whether PR patients (from varied socioeconomic and immune status) harbor the underlying HBV infections. These cases were also investigated for HHV 6 and 7 infections. Read More

    Association of HLA-DQB1*03:03 with pityriasis rosea in Chinese patients.
    Clin Exp Dermatol 2017 Dec 8. Epub 2017 Dec 8.
    Department of Dermatology, No.1 affiliated hospital and Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, China.
    Background: The association of human leucocyte antigen (HLA) with a variety of diseases has been described, especially with various autoimmune diseases. However, there are few studies on the association between HLA and pityriasis rosea (PR).

    Aim: To investigate the relevance of HLA II alleles with the development of PR. Read More

    Recurrent pityriasis rosea: A case report.
    Hum Vaccin Immunother 2017 Nov 28:1-3. Epub 2017 Nov 28.
    a Department of Dermatology , Qianfoshan Hospital, Shandong University , Jinan , Shandong , People's Republic of China.
    Pityriasis rosea is a papulosquamous skin disorder that occurs most commonly between the ages of 10 and 35 years. Recurrent pityriasis rosea is rare. We report a patient suffering from recurrent pityriasis rosea, whose etiology may be related to either vaccine-induced stimulation of the immune system, or some rare vaccine component(influenza A [H1N1] vaccine, hepatitis B vaccine). Read More

    Oropharyngeal lesions in pityriasis rosea.
    J Am Acad Dermatol 2017 Nov 18;77(5):833-837.e4. Epub 2017 Jul 18.
    DISSAL Department of Dermatology, IRCCS AOU San Martino-IST, Genoa, Italy.
    Background: Pityriasis rosea (PR) is an exanthematous disease associated with the endogenous systemic reactivation of human herpesvirus-6 (HHV-6) and human herpesvirus-7 (HHV-7). Oropharyngeal lesions may be associated with the exanthema, but anecdotal evidence suggests that few dermatologists are aware of their occurrence.

    Objective: Classifying oropharyngeal lesions in PR, establishing their prevalence, and assessing their possible association with different PR forms. Read More

    Clinical variants of pityriasis rosea.
    World J Clin Cases 2017 Jun;5(6):203-211
    Francisco Urbina, Emilio Sudy, Dermatologists in Private Practice, Santiago de Chile 6760964, Chile.
    Pityriasis rosea (PR) is a common erythemato-squamous dermatosis which almost always, is easily diagnosed. Mostly the disease presents in its classical form. However, clinical dermatology is all about variations and PR is not an exception. Read More

    Pityriasis rosea-like eruption induced by isotretinoin.
    Cutan Ocul Toxicol 2018 Mar 19;37(1):100-102. Epub 2017 Apr 19.
    a Department of Dermatology , Bozok University School of Medicine , Yozgat , Turkey and.
    Pityriasis rosea is a common, self-limited and inflammatory skin disease. The etiology is not clearly known. Viral agents, autoimmunity, psychogenic factors and drugs have all been suggested as risk factors. Read More

    A retrospective study on rapid plasma reagin testing in patients with Pityriasis rosea.
    Int J STD AIDS 2017 Nov 26;28(13):1348-1351. Epub 2017 Mar 26.
    Department of Dermatology, Weill Cornell Medical College, New York, NY 10021, USA.
    Pityriasis rosea (PR) is an acute self-limited exanthem characterized by oval erythematous patches with scale and may be difficult to differentiate from secondary syphilis. A rapid plasma reagin (RPR) test can be used to rule in secondary syphilis with high sensitivity and specificity. A retrospective study was performed on patients at Weill Cornell Medicine, who were diagnosed with PR from 2000 to 2016 and also received RPR testing at the time of diagnosis. Read More

    Unique clinical presentations of pityriasis rosea: aphthous ulcers, vesicles and inverse distribution of lesions.
    Dermatol Online J 2017 Feb 15;23(2). Epub 2017 Feb 15.
    2Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York.
    Pityriasis Rosea (PR) is a common skin disorderencountered in daily practice. Although its etiologyhas not been established, there has been widespreadresearch into possibilities. The lack of its characteristicmanifestations, specifically the herald patch andtruncal involvement, can lead to pitfalls in diagnosis. Read More

    Common spongiotic dermatoses.
    Semin Diagn Pathol 2017 May 10;34(3):226-236. Epub 2017 Feb 10.
    Department of Radiation Oncology, The Ohio State University, Columbus, OH, USA.
    This review article focuses on the spongiotic tissue reaction pattern and some of the common entities that practicing pathologists can frequently encounter in their practice. The spongiotic tissue reaction pattern is the single most common one encountered in the routine analysis of inflammatory dermatoses, and the most non-specific one as well. Spongiotic dermatoses include a very large list of disorders which are best grouped under neutrophilic, eosinophilic, miliarial, follicular and pityriasiform forms of spogiosis. Read More

    Atypical Pityriasis Rosea with Unilateral Presentation.
    J Clin Diagn Res 2016 Dec 1;10(12):WD01-WD02. Epub 2016 Dec 1.
    Student, Department of Nursing, Student Research Committee, School of Nursing and Midwifery, Iran University of Medical Science , Tehran, Iran .
    Pityriasis Rosea (PR) is a common skin disease and characterized by generalized scaly eruptions typically on the trunk and proximal extremities. Atypical presentations of PR are common and can be a diagnostic challenge for clinicians. Here we present a case of a 26-year-old female who presented with a sudden onset of several asymptomatic, erythematous and scaly plaques on her trunk. Read More

    [Paraviral exanthems].
    Hautarzt 2017 Mar;68(3):211-216
    Department of Dermatology, Godavari Foundation Medical College and Research Center, DUPMCJ, Nashik, Indien.
    Paraviral exanthems are distinct skin diseases due to infections with different viruses. Although no virus has been identified so far in some exanthems, the main age of manifestation, the clinical course of the exanthem, and the extracutaneous symptoms are suggestive for a viral genesis. While many viral infections are a direct result of the infection, paraviral exanthems reflect the response of the immune system to the infectious pathogens. Read More

    Higher Expression of Toll-like Receptors 3, 7, 8, and 9 in Pityriasis Rosea.
    J Pathol Transl Med 2017 Mar 13;51(2):148-151. Epub 2017 Feb 13.
    Department of Molecular Genetics, National Research Center (NRC), Cairo University, Cairo, Egypt.
    Background: Pityriasis rosea (PR) is a common papulosquamous skin disease in which an infective agent may be implicated. Toll-like receptors (TLRs) play an important role in immune responses and in the pathophysiology of inflammatory skin diseases. Our aim was to determine the possible roles of TLRs 3, 7, 8, and 9 in the pathogenesis of PR. Read More

    Gestational Pityriasis Rosea: Suggestions for Approaching Affected Pregnant Women.
    Acta Dermatovenerol Croat 2016 Dec;24(4):312-313
    Efstathia Pasmatzi, MD, Department of Dermatology, School of Medicine, University of Patras, 26504 Rio-Patras, Greece;
    Dear Editor, Pityriasis rosea is a common, acute, and self-limiting dermatosis, which is associated with the endogenous systemic reactivation of human herpesvirus (HHV)-6 and/or HHV-7 (1). It predominantly affects individuals of both sexes in their second or third decade of life and is clinically characterized by the occurrence of an initial erythematosquamous plaque followed by the appearance of disseminated similar but smaller lesions one or two weeks later. Several patients develop systemic symptoms such as nausea, anorexia, malaise, headache, fever, arthralgia, and lymphadenopathy that may precede or accompany the eruption; the latter follows the cleavage lines of the trunk creating the configuration of a Christmas tree and spontaneously resolves within 4 to 8 weeks. Read More

    Is There a Link between Human Herpesvirus Infection and Toll-like Receptors in the Pathogenesis of Pityriasis Rosea? A Case-control Study.
    Acta Dermatovenerol Croat 2016 Dec;24(4):282-287
    Corresponding author: Rania Abdel Hay, MD, 13th Abrag Othman, Kournish el Maadi, Cairo 11431, Egypt;
    Human herpesvirus (HHV) 6 and 7 are involved in the pathogenesis of pityriasis rosea (PR). Our aim was to evaluate the role of the innate immune response in PR through the detection of Toll-like receptors (TLR) 2, 3, 4, 7, 8, and 9 expression in the skin of affected patients and to detect the possibility of being induced by HHV-6 and/or HHV-7 viral coexistence in these patients. Twenty-four patients with PR and 24 healthy controls were included in this case-control study. Read More

    Concurrent pityriasis rosea and Bell's palsy.
    BMJ Case Rep 2017 Jan 23;2017. Epub 2017 Jan 23.
    Department of Dermatology, Saint Louis University, Saint Louis, Missouri, USA.
    Pityriasis rosea is a dermatological disease with a well-documented clinical appearance, but less is known about causes and treatment. Bell's palsy is a neurological condition leading to acute idiopathic hemifacial paralysis. Recent studies indicate that human herpesvirus (HHV) 6-7 reactivation may be a contributing factor to both conditions. Read More

    Pityriasis rosea: a natural history of pediatric cases in theCentral Anatolia Region of Turkey.
    Turk J Med Sci 2016 Dec 20;46(6):1740-1742. Epub 2016 Dec 20.
    Department of Infectious Diseases and Clinical Microbiology, Bolu İzzet Baysal State Hospital, Bolu, Turkey.
    Background/aim: This study aimed to evaluate the demographic, clinical, and epidemiological features of pityriasis rosea (PR) in a cohort of 46 children in Yozgat, a city in the Central Anatolia Region of Turkey.

    Materials And Methods: Forty-six children with PR were monitored at regular intervals (1, 2, 4, and 12 weeks) for 3 months from the time of diagnosis. A complete evaluation of the patient was performed at each visit. Read More

    The role of interleukin-22 in pityriasis rosea.
    Clin Exp Dermatol 2017 Jan 11;42(1):30-35. Epub 2016 Nov 11.
    Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
    Background: Pityriasis rosea (PR) is an exanthematous disease related to reactivation of human herpes virus (HHV) types 6 and 7. The pathogenesis and cytokine profile of PR are still poorly understood.There is a large amount of evidence indicating a viral aetiology for PR. Read More

    c-CBL E3 Ubiquitin Ligase Expression Increases Across the Spectrum of Benign and Malignant T-Cell Skin Diseases.
    Am J Dermatopathol 2017 Oct;39(10):731-737
    *Department of Dermatology, University of Wisconsin, Madison, WI; and †Department of Dermatology, William S. Middleton VA Medical Center, Madison, WI.
    Prolonged survival of lesional T cells plays a central role in the pathogenesis of T-cell-mediated dermatoses. We have recently shown that the ubiquitin ligase c-CBL is highly expressed in cutaneous T-cell lymphoma (CTCL) and that its knockdown increases activation-induced cell death, a key pathway for T-cell apoptosis. Here, we extend our work on c-CBL expression in malignant T cells to their nonneoplastic counterparts in benign inflammatory dermatoses. Read More

    Cutaneous metastasis of inflammatory breast carcinoma mimicking an erythema annulare centrifugum: a sign of locally recurrent cancer.
    Clin Exp Dermatol 2016 Dec 20;41(8):906-910. Epub 2016 Oct 20.
    Department of Oncology, Hospital Casa de Salud, Valencia, Spain.
    Erythema annulare centrifugum (EAC) is a clinical reaction pattern that includes lupus erythematosus, spongiotic dermatitis (particularly pityriasis rosea), pseudolymphoma and cutaneous B-cell lymphoma. However, it can be the result of cutaneous metastasis by an internal carcinoma. We present the case of a 38-year-old woman with bilateral inflammatory breast cancer following multimodal therapy. Read More

    A position statement on the management of patients with pityriasis rosea.
    J Eur Acad Dermatol Venereol 2016 Oct 13;30(10):1670-1681. Epub 2016 Jul 13.
    Histologische Diagnostik, Department of Dermatology, University Hospital Zürich, Zurich, Switzerland.
    Many clinical trials have been conducted on the treatment of pityriasis rosea (PR). Our aim was to establish a position statement for the management of adults with PR based on the best available evidence. We searched PubMed for all reports on randomized controlled trials for the treatment of PR published in the past 30 years. Read More

    Pityriasis rosea in pregnancy: report of a spousal occurrence and craniosynostosis in the healthy newborn.
    Dermatol Pract Concept 2016 Jul 31;6(3):39-46. Epub 2016 Jul 31.
    Department of Dermatology, University of California San Diego, La Jolla, CA, USA.
    Background: Pityriasis rosea is a papulosquamous disease. It may occur during pregnancy; in this setting, it has occasionally been associated with adverse outcomes.

    Purpose: A woman who developed pityriasis rosea at the beginning of her eighth week of gestation is described. Read More

    Dermoscopy in General Dermatology: A Practical Overview.
    Dermatol Ther (Heidelb) 2016 Dec 9;6(4):471-507. Epub 2016 Sep 9.
    Department of Experimental and Clinical Medicine, Institute of Dermatology, University of Udine, Udine, Italy.
    Over the last few years, dermoscopy has been shown to be a useful tool in assisting the noninvasive diagnosis of various general dermatological disorders. In this article, we sought to provide an up-to-date practical overview on the use of dermoscopy in general dermatology by analysing the dermoscopic differential diagnosis of relatively common dermatological disorders grouped according to their clinical presentation, i.e. Read More

    Itch Management in Childhood.
    Curr Probl Dermatol 2016 23;50:173-91. Epub 2016 Aug 23.
    Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Schleswig-Holstein, Kiel, Germany.
    Itch in children is a very common symptom and is mainly related to a skin disease rather than an underlying systemic disorder. The most common dermatoses include atopic dermatitis, contact dermatitis, insect bites, scabies, and pediculosis capitis. There are specific diagnostic patterns which require the evaluation of a careful history and dermatological examination. Read More

    Atypical pityriasis rosea: clinical evaluation of 27 patients.
    Cutan Ocul Toxicol 2017 Jun 26;36(2):157-162. Epub 2016 Sep 26.
    b Yildirim Beyazit University, Medical Faculty , Department of Dermatology , Ankara , Turkey.
    Background: Pityriasis rosea (PR) is a common, acute, self-limiting inflammatory skin disease. It can easily be recognized with its typical clinical presentation. However, unusual clinic presentations can cause difficulty in diagnosis. Read More

    Anesthetic Considerations for Neuraxial Anesthesia in Pregnant Patients With Pityriasis Rosea With Skin Lesions Covering the Lumbar Spine.
    A A Case Rep 2016 Oct;7(8):165-168
    From Oregon Health & Science University, Portland, Oregon.
    Pityriasis rosea (PR) is an acute exanthematous skin disease that is likely due to reactivation of human herpesviruses (HHVs) 6b and 7. In contrast to herpes simplex and zoster (alphaherpesviruses), HHV-6b and -7 (betaherpesviruses) are not found predominantly in skin lesions. This difference in virion location may decrease the possibility of causing central nervous system infection through skin contamination, but the risk for hematogenous spread likely remains the same. Read More

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