J Clin Diagn Res 2017 Jun 1;11(6):WL01. Epub 2017 Jun 1.

Professor, Department of Dermatology, University of Genoa, Genoa, Italy.

J Am Acad Dermatol 2017 Jul 17. Epub 2017 Jul 17.

DISSAL Department of Dermatology, IRCCS AOU San Martino-IST, Genoa, Italy.

Background: Pityriasis rosea (PR) is an exanthematous disease associated with the endogenous systemic reactivation of human herpesvirus-6 (HHV-6) and human herpesvirus-7 (HHV-7). Oropharyngeal lesions may be associated with the exanthema, but anecdotal evidence suggests that few dermatologists are aware of their occurrence.

Objective: Classifying oropharyngeal lesions in PR, establishing their prevalence, and assessing their possible association with different PR forms. Read More

World J Clin Cases 2017 Jun;5(6):203-211

Francisco Urbina, Emilio Sudy, Dermatologists in Private Practice, Santiago de Chile 6760964, Chile.

Pityriasis rosea (PR) is a common erythemato-squamous dermatosis which almost always, is easily diagnosed. Mostly the disease presents in its classical form. However, clinical dermatology is all about variations and PR is not an exception. Read More

Postepy Dermatol Alergol 2017 Jun 29;34(3):276-278. Epub 2017 May 29.

Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland.

Indian Dermatol Online J 2017 May-Jun;8(3):217-218

Department of Pathology, Turgut Ozal University Faculty of Medicine, Ankara, Turkey.

Med Mal Infect 2017 Jun 31;47(4):301-302. Epub 2017 Mar 31.

DISSAL Department of Dermatology, IRCCS AOU, San Martino-IST, Largo Rosanna Benzi, 10, 16132 Genoa, Italy. Electronic address:

Cutan Ocul Toxicol 2017 Apr 19:1-3. Epub 2017 Apr 19.

a Department of Dermatology , Bozok University School of Medicine , Yozgat , Turkey and.

Pityriasis rosea is a common, self-limited and inflammatory skin disease. The etiology is not clearly known. Viral agents, autoimmunity, psychogenic factors and drugs have all been suggested as risk factors. Read More

Int J STD AIDS 2017 Jan 1:956462417702312. Epub 2017 Jan 1.

Department of Dermatology, Weill Cornell Medical College, New York, NY 10021, USA.

Pityriasis rosea (PR) is an acute self-limited exanthem characterized by oval erythematous patches with scale and may be difficult to differentiate from secondary syphilis. A rapid plasma reagin (RPR) test can be used to rule in secondary syphilis with high sensitivity and specificity. A retrospective study was performed on patients at Weill Cornell Medicine, who were diagnosed with PR from 2000 to 2016 and also received RPR testing at the time of diagnosis. Read More

Dermatol Online J 2017 Feb 15;23(2). Epub 2017 Feb 15.

2Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York.

Pityriasis Rosea (PR) is a common skin disorderencountered in daily practice. Although its etiologyhas not been established, there has been widespreadresearch into possibilities. The lack of its characteristicmanifestations, specifically the herald patch andtruncal involvement, can lead to pitfalls in diagnosis. Read More

Semin Diagn Pathol 2017 May 10;34(3):226-236. Epub 2017 Feb 10.

Department of Radiation Oncology, The Ohio State University, Columbus, OH, USA.

This review article focuses on the spongiotic tissue reaction pattern and some of the common entities that practicing pathologists can frequently encounter in their practice. The spongiotic tissue reaction pattern is the single most common one encountered in the routine analysis of inflammatory dermatoses, and the most non-specific one as well. Spongiotic dermatoses include a very large list of disorders which are best grouped under neutrophilic, eosinophilic, miliarial, follicular and pityriasiform forms of spogiosis. Read More

Indian J Dermatol 2017 Jan-Feb;62(1):95

DISSAL Department of Dermatology, IRCCS AOU San Martino-IST, 16132 Genoa, Italy. E-mail:

J Clin Diagn Res 2016 Dec 1;10(12):WD01-WD02. Epub 2016 Dec 1.

Student, Department of Nursing, Student Research Committee, School of Nursing and Midwifery, Iran University of Medical Science , Tehran, Iran .

Pityriasis Rosea (PR) is a common skin disease and characterized by generalized scaly eruptions typically on the trunk and proximal extremities. Atypical presentations of PR are common and can be a diagnostic challenge for clinicians. Here we present a case of a 26-year-old female who presented with a sudden onset of several asymptomatic, erythematous and scaly plaques on her trunk. Read More

JAAD Case Rep 2017 Jan 4;3(1):78-81. Epub 2017 Feb 4.

Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama.

Hautarzt 2017 Mar;68(3):211-216

Department of Dermatology, Godavari Foundation Medical College and Research Center, DUPMCJ, Nashik, Indien.

Paraviral exanthems are distinct skin diseases due to infections with different viruses. Although no virus has been identified so far in some exanthems, the main age of manifestation, the clinical course of the exanthem, and the extracutaneous symptoms are suggestive for a viral genesis. While many viral infections are a direct result of the infection, paraviral exanthems reflect the response of the immune system to the infectious pathogens. Read More

J Pathol Transl Med 2017 Mar 13;51(2):148-151. Epub 2017 Feb 13.

Department of Molecular Genetics, National Research Center (NRC), Cairo University, Cairo, Egypt.

Background: Pityriasis rosea (PR) is a common papulosquamous skin disease in which an infective agent may be implicated. Toll-like receptors (TLRs) play an important role in immune responses and in the pathophysiology of inflammatory skin diseases. Our aim was to determine the possible roles of TLRs 3, 7, 8, and 9 in the pathogenesis of PR. Read More

Int J Dermatol 2017 Jul 10;56(7):e147-e148. Epub 2017 Feb 10.

Department of Dermatology, Seth Gordhandas Sunderdas Medical College and King Edward Memorial Hospital, Mumbai, India.

Acta Dermatovenerol Croat 2016 Dec;24(4):312-313

Efstathia Pasmatzi, MD, Department of Dermatology, School of Medicine, University of Patras, 26504 Rio-Patras, Greece;

Dear Editor, Pityriasis rosea is a common, acute, and self-limiting dermatosis, which is associated with the endogenous systemic reactivation of human herpesvirus (HHV)-6 and/or HHV-7 (1). It predominantly affects individuals of both sexes in their second or third decade of life and is clinically characterized by the occurrence of an initial erythematosquamous plaque followed by the appearance of disseminated similar but smaller lesions one or two weeks later. Several patients develop systemic symptoms such as nausea, anorexia, malaise, headache, fever, arthralgia, and lymphadenopathy that may precede or accompany the eruption; the latter follows the cleavage lines of the trunk creating the configuration of a Christmas tree and spontaneously resolves within 4 to 8 weeks. Read More

Acta Dermatovenerol Croat 2016 Dec;24(4):282-287

Corresponding author: Rania Abdel Hay, MD, 13th Abrag Othman, Kournish el Maadi, Cairo 11431, Egypt;

Human herpesvirus (HHV) 6 and 7 are involved in the pathogenesis of pityriasis rosea (PR). Our aim was to evaluate the role of the innate immune response in PR through the detection of Toll-like receptors (TLR) 2, 3, 4, 7, 8, and 9 expression in the skin of affected patients and to detect the possibility of being induced by HHV-6 and/or HHV-7 viral coexistence in these patients. Twenty-four patients with PR and 24 healthy controls were included in this case-control study. Read More

BMJ Case Rep 2017 Jan 23;2017. Epub 2017 Jan 23.

Department of Dermatology, Saint Louis University, Saint Louis, Missouri, USA.

Pityriasis rosea is a dermatological disease with a well-documented clinical appearance, but less is known about causes and treatment. Bell's palsy is a neurological condition leading to acute idiopathic hemifacial paralysis. Recent studies indicate that human herpesvirus (HHV) 6-7 reactivation may be a contributing factor to both conditions. Read More

Turk J Med Sci 2016 Dec 20;46(6):1740-1742. Epub 2016 Dec 20.

Department of Infectious Diseases and Clinical Microbiology, Bolu İzzet Baysal State Hospital, Bolu, Turkey.

Background/aim: This study aimed to evaluate the demographic, clinical, and epidemiological features of pityriasis rosea (PR) in a cohort of 46 children in Yozgat, a city in the Central Anatolia Region of Turkey.

Materials And Methods: Forty-six children with PR were monitored at regular intervals (1, 2, 4, and 12 weeks) for 3 months from the time of diagnosis. A complete evaluation of the patient was performed at each visit. Read More

Nurse Pract 2017 Jan;42(1):8-11

Kathy VanRavenstein is an instructor at the Medical University of South Carolina, Charleston, S.C. Barbara J. Edlund is a professor at the Medical University of South Carolina, Charleston, S.C.

Indian Dermatol Online J 2016 Nov-Dec;7(6):543-544

Department of Dermatology, Seth Gordhandas Sunderdas Medical College and King Edward Memorial Hospital, Mumbai, Maharashtra, India.

Clin Exp Dermatol 2017 Jan 11;42(1):30-35. Epub 2016 Nov 11.

Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Background: Pityriasis rosea (PR) is an exanthematous disease related to reactivation of human herpes virus (HHV) types 6 and 7. The pathogenesis and cytokine profile of PR are still poorly understood.There is a large amount of evidence indicating a viral aetiology for PR. Read More

Indian J Dermatol Venereol Leprol 2017 Jul-Aug;83(4):516

JC School of Public Health, The Chinese University of Hong Kong and The Prince of Wales Hospital, Shatin, Hong Kong.

Am J Dermatopathol 2016 Oct 31. Epub 2016 Oct 31.

*Department of Dermatology, University of Wisconsin, Madison, WI; and †Department of Dermatology, William S. Middleton VA Medical Center, Madison, WI.

Prolonged survival of lesional T cells plays a central role in the pathogenesis of T-cell-mediated dermatoses. We have recently shown that the ubiquitin ligase c-CBL is highly expressed in cutaneous T-cell lymphoma (CTCL) and that its knockdown increases activation-induced cell death, a key pathway for T-cell apoptosis. Here, we extend our work on c-CBL expression in malignant T cells to their nonneoplastic counterparts in benign inflammatory dermatoses. Read More

J Eur Acad Dermatol Venereol 2016 Nov 7;30(11):e133-e134. Epub 2015 Oct 7.

Department of Dermatology, The Mater Misericordiae University Hospital, Dublin, Ireland.

Clin Exp Dermatol 2016 Dec 20;41(8):906-910. Epub 2016 Oct 20.

Department of Oncology, Hospital Casa de Salud, Valencia, Spain.

Erythema annulare centrifugum (EAC) is a clinical reaction pattern that includes lupus erythematosus, spongiotic dermatitis (particularly pityriasis rosea), pseudolymphoma and cutaneous B-cell lymphoma. However, it can be the result of cutaneous metastasis by an internal carcinoma. We present the case of a 38-year-old woman with bilateral inflammatory breast cancer following multimodal therapy. Read More

J Eur Acad Dermatol Venereol 2016 Oct 13;30(10):1670-1681. Epub 2016 Jul 13.

Histologische Diagnostik, Department of Dermatology, University Hospital Zürich, Zurich, Switzerland.

Many clinical trials have been conducted on the treatment of pityriasis rosea (PR). Our aim was to establish a position statement for the management of adults with PR based on the best available evidence. We searched PubMed for all reports on randomized controlled trials for the treatment of PR published in the past 30 years. Read More

Indian Dermatol Online J 2016 Sep-Oct;7(5):435

Department of Dermatology, IRCCS AOU San Martino-IST, 16132 Genoa, Italy.

Dermatol Pract Concept 2016 Jul 31;6(3):39-46. Epub 2016 Jul 31.

Department of Dermatology, University of California San Diego, La Jolla, CA, USA.

Background: Pityriasis rosea is a papulosquamous disease. It may occur during pregnancy; in this setting, it has occasionally been associated with adverse outcomes.

Purpose: A woman who developed pityriasis rosea at the beginning of her eighth week of gestation is described. Read More

Dermatol Ther (Heidelb) 2016 Dec 9;6(4):471-507. Epub 2016 Sep 9.

Department of Experimental and Clinical Medicine, Institute of Dermatology, University of Udine, Udine, Italy.

Over the last few years, dermoscopy has been shown to be a useful tool in assisting the noninvasive diagnosis of various general dermatological disorders. In this article, we sought to provide an up-to-date practical overview on the use of dermoscopy in general dermatology by analysing the dermoscopic differential diagnosis of relatively common dermatological disorders grouped according to their clinical presentation, i.e. Read More

Curr Probl Dermatol 2016 23;50:173-91. Epub 2016 Aug 23.

Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Schleswig-Holstein, Kiel, Germany.

Itch in children is a very common symptom and is mainly related to a skin disease rather than an underlying systemic disorder. The most common dermatoses include atopic dermatitis, contact dermatitis, insect bites, scabies, and pediculosis capitis. There are specific diagnostic patterns which require the evaluation of a careful history and dermatological examination. Read More

Cutan Ocul Toxicol 2017 Jun 26;36(2):157-162. Epub 2016 Sep 26.

b Yildirim Beyazit University, Medical Faculty , Department of Dermatology , Ankara , Turkey.

Background: Pityriasis rosea (PR) is a common, acute, self-limiting inflammatory skin disease. It can easily be recognized with its typical clinical presentation. However, unusual clinic presentations can cause difficulty in diagnosis. Read More

A A Case Rep 2016 Oct;7(8):165-168

From Oregon Health & Science University, Portland, Oregon.

Pityriasis rosea (PR) is an acute exanthematous skin disease that is likely due to reactivation of human herpesviruses (HHVs) 6b and 7. In contrast to herpes simplex and zoster (alphaherpesviruses), HHV-6b and -7 (betaherpesviruses) are not found predominantly in skin lesions. This difference in virion location may decrease the possibility of causing central nervous system infection through skin contamination, but the risk for hematogenous spread likely remains the same. Read More

Indian J Dermatol 2016 Jul-Aug;61(4):375-84

Maulana Azad Medical College, New Delhi, India.

Pityriasis rosea (PR) is a benign papulosquamous disorder seen commonly in clinical practice. Despite its prevalence and benign nature, there are still times when this common disorder presents in an uncommon way or course posing diagnostic or management problems for the treating physician. The etiopathogenesis of PR has always been a dilemma, and extensive research is going on to elicit the exact cause. Read More

J Clin Diagn Res 2016 Jun 1;10(6):EC19-22. Epub 2016 Jun 1.

Professor and Head, Department of Pathology, A J Institute of Medical Sciences , Kuntikana, Mangalore, Karnataka, India .

Introduction: Papulosquamous diseases are characterized by scaly papules and plaques with similar clinical picture which amounts to confusion and hence, a definitive histopathological diagnosis goes a long way in treatment of such diseases.

Aim: The aim of the study was to study the histomorphology of non-infectious, erythaematous, papulosquamous lesions of skin with clinicopathological correlation.

Materials And Methods: Skin biopsies from 150 clinically diagnosed/suspected non-infectious erythaematous, papulosquamous skin diseases were received in the Department of Pathology. Read More

Pediatr Dermatol 2016 Sep 11;33(5):e286-7. Epub 2016 Jul 11.

JC School of Public Health, Chinese University of Hong Kong and Prince of Wales Hospital, Shatin, Hong Kong, China.

An 18-month-old girl presented with pityriasis rosea gigantea. The herald patch encircled almost the entire trunk. The distribution of lesions on the trunk and proximal aspects of the limbs, the collarette scaling, the orientation of some lesions along the skin crease lines, and biopsy findings substantiated the diagnosis. Read More

Indian Dermatol Online J 2016 May-Jun;7(3):212-5

Department of Dermatology, Medical College and Hospital, Kolkata, West Bengal, India.

Clin Dermatol 2016 May-Jun;34(3):335-43. Epub 2016 Feb 11.

Department of Dermatology, Warren Alpert Medical School of Brown University, Providence, Rhode Island; Department of Dermatology, Rhode Island Hospital, Providence, Rhode Island.

A switch from cell-mediated to humoral immunity (helper T 1 [Th1] to helper T 2 [Th2] shift) during gestation plays a key role in placental immune tolerance. As a result, skin diseases that are Th2 mediated often worsen, whereas skin diseases that are Th1 mediated often improve during gestation. Also, due to fluctuations in glandular activity, skin diseases involving sebaceous and eccrine glands may flare, whereas those involving apocrine glands may improve during pregnancy. Read More

J Clin Med Res 2016 Jun 25;8(6):445-8. Epub 2016 May 25.

Department of Statistics, Ondokuz Mayis University School of Medicine Samsun, Turkey.

Background: Pityriasis rosea (PR) is an inflammatory skin disorder of unknown etiology. However, it is suggested to be related with the reactivation of human herpes virus 7 (HHV-7) and/or HHV-6. It is sometimes diffucult to distinguish PR from PR-like drug eruptions and other inflammatory disorders, so we need new parameters which are cheap and easy in determining PR. Read More

Indian J Dermatol Venereol Leprol 2016 Sep-Oct;82(5):505-9

Department of Community Medicine, Government Medical College, Kannauj, Uttar Pradesh, India.

Background: Acyclovir is considered to be an effective treatment for pityriasis rosea but randomized, blinded, placebo-controlled trials have not been performed.

Aims: To test the efficacy of acyclovir in pityriasis rosea in a randomized, triple-blind, placebo-controlled trial.

Methods: Twenty seven patients with pityriasis rosea were randomly allocated to receive placebo (n = 13) or acyclovir (800 mg five times daily for one week) (n = 14). Read More

Expert Rev Anti Infect Ther 2016 Jun;14(6):601-11

c School of Public Health and Primary Care , The Chinese University of Hong Kong and Prince of Wales Hospital , Shatin , Hong Kong.

Introduction: Paraviral exanthems are skin diseases suspected to be caused by viruses, with a single virus-exanthem relationship not universally accepted. Although most paraviral exanthems are self-remitting, accurate diagnoses are important as some patients might develop complications. Some of the differential diagnoses might cause serious complications, and some paraviral exanthems might lead to complications for at-risk groups such as pregnant women. Read More

Infect Dis Rep 2016 Mar 21;8(1):6418. Epub 2016 Mar 21.

JC School of Public Health and Primary Care, The Chinese University of Hong Kong and Prince of Wales Hospital , Shatin, Hong Kong.

Many clinical and laboratory-based studies have been reported for skin rashes which may be due to viral infections, namely pityriasis rosea (PR), Gianotti-Crosti syndrome (GCS), asymmetric periflexural exanthem/unilateral laterothoracic exanthem (APE/ULE), papular-purpuric gloves and socks syndrome (PPGSS), and eruptive pseudo-angiomatosis (EP). Eruptive hypomelanosis (EH) is a newly discovered paraviral rash. Novel tools are now available to investigate the epidemiology of these rashes. Read More

Dermatology 2016 21;232(4):431-7. Epub 2016 Apr 21.

DISSAL, Department of Dermatology, IRCCS AOU San Martino-IST, University of Genoa, Genoa, Italy.

Pityriasis rosea (PR) is an acute, self-limiting exanthematous disease associated with the endogenous systemic reactivation of human herpesvirus (HHV)-6 and/or HHV-7. The disease typically begins with a single, erythematous plaque followed by a secondary eruption with lesions on the cleavage lines of the trunk (configuration of a 'Christmas tree'). The duration may vary from 2 weeks to a few months. Read More

Int J Dermatol 2016 Oct 7;55(10):1115-8. Epub 2016 Apr 7.

Temple University School of Medicine, Philadelphia, PA, USA.

Background: Certain dermatologic conditions are known to show seasonal variations in frequency, the reasons for which are unclear but in some cases may be attributable to changes in ambient weather conditions.

Objectives: The current study was conducted to determine whether seasonal trends might exist for dermatologic conditions including erythema multiforme, guttate psoriasis, erythema dyschromicum perstans (ashy dermatosis), pityriasis lichenoides, and pityriasis rosea.

Methods: Data were derived from a 15-year retrospective review of electronic records from a large dermatopathology laboratory located in the mid-Atlantic region of the USA. Read More

JAAD Case Rep 2015 Jul 10;1(4):185-7. Epub 2015 Jun 10.

Department of Dermatology, Columbia University, New York, New York.

Int J Dermatol 2016 Sep 24;55(9):939-55. Epub 2016 Mar 24.

Division of Clinical Dermatology, Mayo Clinic, Rochester, MN, USA.

Many skin and skin-related diseases affect the sexes unequally, with attendant implications for public health and resource allocation. To evaluate better the incidence of skin and skin-related diseases affecting males vs. females, we reviewed published population-based epidemiology studies of skin disorders performed utilizing Rochester Epidemiology Project data. Read More

Indian J Dermatol 2016 Jan-Feb;61(1):118

Department of Biochemistry, Atatürk Training and Research Hospital, Ankara, Turkey.

Background: Pityriasis rosea (PR) is usually an asymptomatic and self-limiting papulosquamous skin disease with acute onset. The etiology has not been clarified yet. Recently, increased oxidative stress was found to play a role in etiopathogenesis of multiple cutaneous diseases with T cell-mediated immune response. Read More

Clin Dermatol 2016 Jan-Feb;34(1):3-7. Epub 2015 Nov 17.

Domestic and Specialized Medicine Centre "Dilmed", ul. Bohaterów Monte Cassino 3, 40-231 Katowice, Poland. Electronic address:

For many years, the biblical term tzaraat has referred to leprosy. In fact, the disease or diseases described under this name have no relationship to leprosy, as it was known in the Middle Ages or today; moreover, the term referred not only to skin disease, but also to the state of the ritual impurity and punishment for the sins. Although the real nature of tzaraat remains unknown, the differential diagnosis might include the following: Psoriasis, seborrheic dermatitis, favus, dermatophyte infections, nummular dermatitis, atopic dermatitis, pityriasis rosea, crusted scabies, syphilis, impetigo, sycosis barbae, alopecia areata, furuncles, scabies, neurodermatitis, scarlet fever, lupus erythematosus, lichen sclerosus et atrophicus, folliculitis decalvans, morphea, sarcoidosis, and lichen planopilaris. Read More

Indian J Pharmacol 2015 Nov-Dec;47(6):680-1

Department of Dermatology, Christian Medical College, Ludhiana, Punjab, India.

Terbinafine is an allylamine antifungal agent which is widely used for the treatment of fungal infections. Cutaneous side effects have been reported in 2% of the patients on terbinafine therapy with many morphological patterns. We report a case of terbinafine induced pityriasis rosea, a very rare side effect of terbinafine. Read More