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Evid Based Complement Alternat Med 2018 27;2018:6816981. Epub 2018 Mar 27.

Department of Scientific Research, The First Affiliated Hospital, Xi'an Medical University, Xi'an, China.

Pityriasis rosea (PR), a skin rash, causes substantial discomfort in patients. There is a lack of effective therapies for PR. A combination of ultraviolet irradiation and treatment has been shown to be a safe and effective regime for control of PR; however, the data have been largely inconsistent. Read More

Pediatrics 2018 May 19;141(5). Epub 2018 Apr 19.

Laboratoire de Virologie EA3610, University Lille and Faculté de Médecine, Centre Hospitalier Régional Universitaire de Lille, Lille, France.

Pityriasis rosea (PR) usually presents as acute exanthema with oval erythematous-squamous lesions localized on the trunk, arms, and legs with spontaneous remission. We present an unusual case of PR with frequent relapses during a period of 7 years. An 11-year-old white female patient presented with many pruritic erythematous oval lesions on her trunk. Read More

Indian Dermatol Online J 2018 Mar-Apr;9(2):131-132

Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Postepy Dermatol Alergol 2018 Feb 20;35(1):116-117. Epub 2018 Feb 20.

Department of Dermatology, IRCCS A.O.U. San Martino-IST, Genoa, Italy.

Br J Clin Pharmacol 2018 May 9;84(5):1077-1080. Epub 2018 Mar 9.

Department of Experimental Pathology, Immunology and Microbiology, Faculty of Medicine, American University of Beirut Medical Center, Beirut, Lebanon.

A 30-year-old pregnant female presented with a 2-week history of pityriasis rosea-like eruption. The rash started 2 days after the patient had started taking ondansetron 8 mg for alleviation of moderate-to-severe nausea and vomiting of pregnancy. Physical examination revealed erythematous papulosquamous lesions characterized by annular scaly margins and a dusky centre over the arms, chest, abdomen, lower back and legs. Read More

Cureus 2017 Dec 19;9(12):e1961. Epub 2017 Dec 19.

Department of Dermatology, University of California, San Diego.

Scabies, a mite infestation caused by 'Sarcoptes scabiei', most commonly presents as pruritic linear burrows where the mite has invaded the skin. Scabies variant such as bullous, crusted, hidden, incognito, nodular and scalp-mimic the other conditions. In addition, atypical presentations of scabies can masquerade as dermatitis herpetiformis, ecchymosis, Langerhans cell histiocytosis, systemic lupus erythematosus, urticaria, and urticaria pigmentosa. Read More

Dermatol Online J 2017 Aug 15;23(8). Epub 2017 Aug 15.

Department of Dermatology, IRCCS AOU San Martino, Genoa, Italy.

Pityriasis rosea (PR) may have atypical presentations as regards morphology and distribution of the lesions. Recently, several forms of PR considered atypical for the course of the disease have been described. Differently from the typical PR that resolves within 2-12 weeks, relapsing and persistent PR forms (lasting longer than 12 weeks) have been described in adults and children. Read More

Pediatr Dermatol 2018 Mar 13;35(2):e124-e127. Epub 2018 Feb 13.

Division of Dermatology, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.

Oral lesions are rarely reported in patients with pityriasis rosea. We report a case of a 3-year-old boy with clinical evidence of generalized pityriasis rosea who developed asymptomatic oral lesions similar in appearance to geographic tongue. The generalized eruption and tongue lesions resolved simultaneously within 4 weeks. Read More

Am Fam Physician 2018 Jan;97(1):Online

JAAD Case Rep 2018 Jan 19;4(1):55-57. Epub 2017 Dec 19.

Department of Dermatology, Tulane University, New Orleans, Louisiana.

Int J Dermatol 2018 Jan 29. Epub 2018 Jan 29.

Division of Clinical Dermatology, Mayo Clinic, Rochester, MN, USA.

Understanding the effects of age on the epidemiology of diseases primarily affecting the skin is important to the practice of dermatology, both for proper allocation of resources and for optimal patient-centered care. To fully appreciate the effect that age may have on the population-based calculations of incidence of diseases primarily affecting the skin in Olmsted County, Minnesota, and worldwide, we performed a review of all relevant Rochester Epidemiology Project-published data and compared them to similar reports in the worldwide English literature. Using the Rochester Epidemiology Project, population-based epidemiologic studies have been performed to estimate the incidence of specific skin diseases over the past 50 years. Read More

Am Fam Physician 2018 Jan;97(1):Online

Am Fam Physician 2018 Jan;97(1):38-44

Emory University School of Medicine, Atlanta, GA, USA.

Pityriasis rosea is a common self-limiting rash that usually starts with a herald patch on the trunk and progresses along the Langer lines to a generalized rash over the trunk and limbs. The diagnosis is based on clinical and physical examination findings. The herald patch is an erythematous lesion with an elevated border and depressed center. Read More

J Dermatolog Treat 2018 Feb 1:1-6. Epub 2018 Feb 1.

g Skin-Aid Clinic , Gurugram , India.

Purpose: To evaluate the efficacy and safety of short-course low-dose oral prednisolone in symptomatic pityriasis rosea (PR) of onset <5 days and compare it with placebo.

Material And Methods: Placebo-controlled randomized double-blind study design with the treatment group receiving tapering doses of oral prednisolone over 2 weeks and the control group receiving a placebo. Outcome measures evaluated were subsidence of patient-perceived pruritus, improvement in rash quantified by a specific score, adverse effects and relapse at 12 weeks. Read More

Turk J Pediatr 2017 ;59(2):214-216

Department of Dermatology and Venereology, Gaziosmanpaşa University Faculty of Medicine, Tokat, Turkey.

Oğrum A. Unilateral pityriasis rosea in a child: A rare clinical presentation. Turk J Pediatr 2017; 59: 214-216. Read More

Indian J Dermatol 2017 Nov-Dec;62(6):598-605

Infectious Diseases & Immunology Division, CSIR Indian Institute of Chemical Biology, Kolkata, West Bengal, India.

Background: The etiopathogenesis of (PR), a papulo-squamous skin disease, remains elusive and hypothesized to be caused primarily by human herpesvirus (HHV) 6 or 7 or immune dysfunction.

Aims: The recent increasing incidences of hepatitis B virus (HBV) infections, including asymptomatic occult HBV infections (OBIs), in a densely populated city in India, prompted us to investigate whether PR patients (from varied socioeconomic and immune status) harbor the underlying HBV infections. These cases were also investigated for HHV 6 and 7 infections. Read More

Clin Exp Dermatol 2018 Jun 8;43(4):389-392. Epub 2017 Dec 8.

Department of Dermatology, No.1 affiliated hospital and Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, China.

Background: The association of human leucocyte antigen (HLA) with a variety of diseases has been described, especially with various autoimmune diseases. However, there are few studies on the association between HLA and pityriasis rosea (PR).

Aim: To investigate the relevance of HLA II alleles with the development of PR. Read More

Hum Vaccin Immunother 2018 Apr 21;14(4):1024-1026. Epub 2017 Dec 21.

a Department of Dermatology , Qianfoshan Hospital, Shandong University , Jinan , Shandong , People's Republic of China.

Pityriasis rosea is a papulosquamous skin disorder that occurs most commonly between the ages of 10 and 35 years. Recurrent pityriasis rosea is rare. We report a patient suffering from recurrent pityriasis rosea, whose etiology may be related to either vaccine-induced stimulation of the immune system, or some rare vaccine component(influenza A [H1N1] vaccine, hepatitis B vaccine). Read More

Turk J Med Sci 2017 08 23;47(4):1302-1305. Epub 2017 Aug 23.

G Ital Dermatol Venereol 2017 Nov 16. Epub 2017 Nov 16.

DISSAL Department of Dermatology, IRCCS A.O.U, San Martino-IST, Genoa, Italy.

Iran J Pathol 2016 ;11(4):416-417

Skin Diseases Center, Nashik, India.

J Clin Diagn Res 2017 Jun 1;11(6):WL01. Epub 2017 Jun 1.

Professor, Department of Dermatology, University of Genoa, Genoa, Italy.

J Am Acad Dermatol 2017 Nov 18;77(5):833-837.e4. Epub 2017 Jul 18.

DISSAL Department of Dermatology, IRCCS AOU San Martino-IST, Genoa, Italy.

Background: Pityriasis rosea (PR) is an exanthematous disease associated with the endogenous systemic reactivation of human herpesvirus-6 (HHV-6) and human herpesvirus-7 (HHV-7). Oropharyngeal lesions may be associated with the exanthema, but anecdotal evidence suggests that few dermatologists are aware of their occurrence.

Objective: Classifying oropharyngeal lesions in PR, establishing their prevalence, and assessing their possible association with different PR forms. Read More

World J Clin Cases 2017 Jun;5(6):203-211

Francisco Urbina, Emilio Sudy, Dermatologists in Private Practice, Santiago de Chile 6760964, Chile.

Pityriasis rosea (PR) is a common erythemato-squamous dermatosis which almost always, is easily diagnosed. Mostly the disease presents in its classical form. However, clinical dermatology is all about variations and PR is not an exception. Read More

Postepy Dermatol Alergol 2017 Jun 29;34(3):276-278. Epub 2017 May 29.

Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland.

World J Gastroenterol 2017 Jun;23(21):3934-3944

Zong-Ming Zhang, Fang-Cai Lin, Zhuo Liu, Li-Min Liu, Chong Zhang, Hong-Wei Yu, Hai Deng, Ming-Wen Zhu, Zi-Xu Liu, Bai-Jiang Wan, Hai-Yan Yang, Jia-Hong Liao, Xu Luo, You-Wei Li, Wen-Ping Wei, Meng-Meng Song, Yue Zhao, Department of General Surgery, Beijing Electric Power Hospital, State Grid Corporation of China, Capital Medical University, Beijing 100073, China.

A 48-year-old woman was admitted with 15-mo history of abdominal pain, diarrhea and hematochezia, and 5-mo history of defecation difficulty. She had been successively admitted to nine hospitals, with an initial diagnosis of inflammatory bowel disease with stenotic sigmoid colon. Findings from computed tomography virtual colonoscopy, radiography with meglumine diatrizoate, endoscopic balloon dilatation, metallic stent implantation and later overall colonoscopy, coupled with the newfound knowledge of compound Qingdai pill-taking, led to a subsequent diagnosis of ischemic or toxic bowel disease with sigmoid colon stenosis. Read More

Indian Dermatol Online J 2017 May-Jun;8(3):217-218

Department of Pathology, Turgut Ozal University Faculty of Medicine, Ankara, Turkey.

Med Mal Infect 2017 Jun 31;47(4):301-302. Epub 2017 Mar 31.

DISSAL Department of Dermatology, IRCCS AOU, San Martino-IST, Largo Rosanna Benzi, 10, 16132 Genoa, Italy. Electronic address:

Cutan Ocul Toxicol 2018 Mar 19;37(1):100-102. Epub 2017 Apr 19.

a Department of Dermatology , Bozok University School of Medicine , Yozgat , Turkey and.

Pityriasis rosea is a common, self-limited and inflammatory skin disease. The etiology is not clearly known. Viral agents, autoimmunity, psychogenic factors and drugs have all been suggested as risk factors. Read More

Int J STD AIDS 2017 11 26;28(13):1348-1351. Epub 2017 Mar 26.

Department of Dermatology, Weill Cornell Medical College, New York, NY 10021, USA.

Pityriasis rosea (PR) is an acute self-limited exanthem characterized by oval erythematous patches with scale and may be difficult to differentiate from secondary syphilis. A rapid plasma reagin (RPR) test can be used to rule in secondary syphilis with high sensitivity and specificity. A retrospective study was performed on patients at Weill Cornell Medicine, who were diagnosed with PR from 2000 to 2016 and also received RPR testing at the time of diagnosis. Read More

Dermatol Online J 2017 Feb 15;23(2). Epub 2017 Feb 15.

2Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York.

Pityriasis Rosea (PR) is a common skin disorderencountered in daily practice. Although its etiologyhas not been established, there has been widespreadresearch into possibilities. The lack of its characteristicmanifestations, specifically the herald patch andtruncal involvement, can lead to pitfalls in diagnosis. Read More

Semin Diagn Pathol 2017 May 10;34(3):226-236. Epub 2017 Feb 10.

Department of Radiation Oncology, The Ohio State University, Columbus, OH, USA.

This review article focuses on the spongiotic tissue reaction pattern and some of the common entities that practicing pathologists can frequently encounter in their practice. The spongiotic tissue reaction pattern is the single most common one encountered in the routine analysis of inflammatory dermatoses, and the most non-specific one as well. Spongiotic dermatoses include a very large list of disorders which are best grouped under neutrophilic, eosinophilic, miliarial, follicular and pityriasiform forms of spogiosis. Read More

Indian J Dermatol 2017 Jan-Feb;62(1):95

DISSAL Department of Dermatology, IRCCS AOU San Martino-IST, 16132 Genoa, Italy. E-mail:

J Clin Diagn Res 2016 Dec 1;10(12):WD01-WD02. Epub 2016 Dec 1.

Student, Department of Nursing, Student Research Committee, School of Nursing and Midwifery, Iran University of Medical Science , Tehran, Iran .

Pityriasis Rosea (PR) is a common skin disease and characterized by generalized scaly eruptions typically on the trunk and proximal extremities. Atypical presentations of PR are common and can be a diagnostic challenge for clinicians. Here we present a case of a 26-year-old female who presented with a sudden onset of several asymptomatic, erythematous and scaly plaques on her trunk. Read More

JAAD Case Rep 2017 Jan 4;3(1):78-81. Epub 2017 Feb 4.

Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama.

Hautarzt 2017 Mar;68(3):211-216

Department of Dermatology, Godavari Foundation Medical College and Research Center, DUPMCJ, Nashik, Indien.

Paraviral exanthems are distinct skin diseases due to infections with different viruses. Although no virus has been identified so far in some exanthems, the main age of manifestation, the clinical course of the exanthem, and the extracutaneous symptoms are suggestive for a viral genesis. While many viral infections are a direct result of the infection, paraviral exanthems reflect the response of the immune system to the infectious pathogens. Read More

J Pathol Transl Med 2017 Mar 13;51(2):148-151. Epub 2017 Feb 13.

Department of Molecular Genetics, National Research Center (NRC), Cairo University, Cairo, Egypt.

Background: Pityriasis rosea (PR) is a common papulosquamous skin disease in which an infective agent may be implicated. Toll-like receptors (TLRs) play an important role in immune responses and in the pathophysiology of inflammatory skin diseases. Our aim was to determine the possible roles of TLRs 3, 7, 8, and 9 in the pathogenesis of PR. Read More

Int J Dermatol 2017 Jul 10;56(7):e147-e148. Epub 2017 Feb 10.

Department of Dermatology, Seth Gordhandas Sunderdas Medical College and King Edward Memorial Hospital, Mumbai, India.

Acta Dermatovenerol Croat 2016 Dec;24(4):312-313

Efstathia Pasmatzi, MD, Department of Dermatology, School of Medicine, University of Patras, 26504 Rio-Patras, Greece;

Dear Editor, Pityriasis rosea is a common, acute, and self-limiting dermatosis, which is associated with the endogenous systemic reactivation of human herpesvirus (HHV)-6 and/or HHV-7 (1). It predominantly affects individuals of both sexes in their second or third decade of life and is clinically characterized by the occurrence of an initial erythematosquamous plaque followed by the appearance of disseminated similar but smaller lesions one or two weeks later. Several patients develop systemic symptoms such as nausea, anorexia, malaise, headache, fever, arthralgia, and lymphadenopathy that may precede or accompany the eruption; the latter follows the cleavage lines of the trunk creating the configuration of a Christmas tree and spontaneously resolves within 4 to 8 weeks. Read More

Acta Dermatovenerol Croat 2016 Dec;24(4):282-287

Corresponding author: Rania Abdel Hay, MD, 13th Abrag Othman, Kournish el Maadi, Cairo 11431, Egypt;

Human herpesvirus (HHV) 6 and 7 are involved in the pathogenesis of pityriasis rosea (PR). Our aim was to evaluate the role of the innate immune response in PR through the detection of Toll-like receptors (TLR) 2, 3, 4, 7, 8, and 9 expression in the skin of affected patients and to detect the possibility of being induced by HHV-6 and/or HHV-7 viral coexistence in these patients. Twenty-four patients with PR and 24 healthy controls were included in this case-control study. Read More

BMJ Case Rep 2017 Jan 23;2017. Epub 2017 Jan 23.

Department of Dermatology, Saint Louis University, Saint Louis, Missouri, USA.

Pityriasis rosea is a dermatological disease with a well-documented clinical appearance, but less is known about causes and treatment. Bell's palsy is a neurological condition leading to acute idiopathic hemifacial paralysis. Recent studies indicate that human herpesvirus (HHV) 6-7 reactivation may be a contributing factor to both conditions. Read More

Turk J Med Sci 2016 Dec 20;46(6):1740-1742. Epub 2016 Dec 20.

Department of Infectious Diseases and Clinical Microbiology, Bolu İzzet Baysal State Hospital, Bolu, Turkey.

Background/aim: This study aimed to evaluate the demographic, clinical, and epidemiological features of pityriasis rosea (PR) in a cohort of 46 children in Yozgat, a city in the Central Anatolia Region of Turkey.

Materials And Methods: Forty-six children with PR were monitored at regular intervals (1, 2, 4, and 12 weeks) for 3 months from the time of diagnosis. A complete evaluation of the patient was performed at each visit. Read More

Nurse Pract 2017 Jan;42(1):8-11

Kathy VanRavenstein is an instructor at the Medical University of South Carolina, Charleston, S.C. Barbara J. Edlund is a professor at the Medical University of South Carolina, Charleston, S.C.

Indian Dermatol Online J 2016 Nov-Dec;7(6):543-544

Department of Dermatology, Seth Gordhandas Sunderdas Medical College and King Edward Memorial Hospital, Mumbai, Maharashtra, India.

Clin Exp Dermatol 2017 Jan 11;42(1):30-35. Epub 2016 Nov 11.

Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Background: Pityriasis rosea (PR) is an exanthematous disease related to reactivation of human herpes virus (HHV) types 6 and 7. The pathogenesis and cytokine profile of PR are still poorly understood.There is a large amount of evidence indicating a viral aetiology for PR. Read More

Indian J Dermatol Venereol Leprol 2017 Jul-Aug;83(4):516

JC School of Public Health, The Chinese University of Hong Kong and The Prince of Wales Hospital, Shatin, Hong Kong.

Am J Dermatopathol 2017 Oct;39(10):731-737

*Department of Dermatology, University of Wisconsin, Madison, WI; and †Department of Dermatology, William S. Middleton VA Medical Center, Madison, WI.

Prolonged survival of lesional T cells plays a central role in the pathogenesis of T-cell-mediated dermatoses. We have recently shown that the ubiquitin ligase c-CBL is highly expressed in cutaneous T-cell lymphoma (CTCL) and that its knockdown increases activation-induced cell death, a key pathway for T-cell apoptosis. Here, we extend our work on c-CBL expression in malignant T cells to their nonneoplastic counterparts in benign inflammatory dermatoses. Read More

J Eur Acad Dermatol Venereol 2016 Nov 7;30(11):e133-e134. Epub 2015 Oct 7.

Department of Dermatology, The Mater Misericordiae University Hospital, Dublin, Ireland.

Clin Exp Dermatol 2016 Dec 20;41(8):906-910. Epub 2016 Oct 20.

Department of Oncology, Hospital Casa de Salud, Valencia, Spain.

Erythema annulare centrifugum (EAC) is a clinical reaction pattern that includes lupus erythematosus, spongiotic dermatitis (particularly pityriasis rosea), pseudolymphoma and cutaneous B-cell lymphoma. However, it can be the result of cutaneous metastasis by an internal carcinoma. We present the case of a 38-year-old woman with bilateral inflammatory breast cancer following multimodal therapy. Read More