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J Drugs Dermatol 2020 May;19(5):560-561

Background: Pityriasis lichenoides chronica, a papulosquamous disorder often considered a subtype of pityriasis lichenoides. It is considered a clonal T-cell disorder, which may be associated with cutaneous T-cell lymphoma that may develops in response to foreign antigens.

Case Presentation: We present a 38-year-old male patient with ankylosing spondylitis who was on treatment with etanercept. Read More

Indian J Dermatol Venereol Leprol 2020 May 28. Epub 2020 May 28.

Department of Dermatology, Venereology and Leprosy, JSS Medical College, Mysore, Karnataka, India.

Clin Neurol Neurosurg 2020 May 5;195:105886. Epub 2020 May 5.

Department of Neurology, George Washington University, Washington, DC, United States; Department of Neurology, Veterans Affairs (VA) Multiple Sclerosis Centers of Excellence, Washington, DC, United States.

Korean J Fam Med 2020 May 21. Epub 2020 May 21.

Department of Dermatology, Hospital Raja Perempuan Zainab II, Kota Bahru, Malaysia.

Primary cutaneous lymphomas are rare diseases among the general population, and even rarer in children. Mycosis fungoides (MF) is the most commonly diagnosed form in childhood. Several atypical clinical variants of MF have been reported, and pityriasis lichenoides-like MF (PL-like MF) is a recently described subtype. Read More

Pediatr Dermatol 2020 Apr 30. Epub 2020 Apr 30.

Division of Paediatric Dermatology, Children's Hospital AUF DER BULT, Hannover, Germany.

Although the clinical presentations of patients with pityriasis lichenoides et varioliformis acuta (PLEVA) may vary, bullae are not usually part of the clinical spectrum. To date, only two other cases of a bullous variant of PLEVA with evidence of autoantibodies against hemidesmosomal antigens have been reported. The term PLEVA pemphigoides was suggested for this unique clinical, pathological and serological combination of both PLEVA and bullous pemphigoid. Read More

Australas J Dermatol 2020 Apr 20. Epub 2020 Apr 20.

Department of Dermatology, Saiseikai Central Hospital, Tokyo, Japan.

Dermatology 2020 Mar 27:1-6. Epub 2020 Mar 27.

Pediatric Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Background: Mycoplasma pneumoniae pneumonia is sometimes associated with skin or mucous membrane eruptions. Available reviews do not address the association of Chlamydophila pneumoniae pneumonia with skin eruptions. We therefore conducted a systematic review of the literature addressing this issue. Read More

Acta Derm Venereol 2020 Mar 18;100(6):adv00089. Epub 2020 Mar 18.

Service of Dermatology, General University Hospital of Alicante, C/ Pintor Baeza, 12, ES-03010 Alicante, Spain.

The aim of this prospective study in a phototherapy unit was to describe adverse events (AEs) associated with discontinuation of phototherapy in a clinical setting. A total of 872 included patients received 1,256 courses of phototherapy treatment: 76.9% narrow-band UVB (NBUVB); 9. Read More

Dermatol Ther 2020 Mar 16:e13311. Epub 2020 Mar 16.

Department of Dermatology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.

Pityriasis lichenoides (PL) is an uncommon cutaneous disorder. Oral erythromycin is proposed to be effective in treating the disease. Here, we reported 16 pediatric patients with PL and systematically reviewed published literatures on erythromycin treatment response in pediatric PL patients, to observe the different treatment response to erythromycin in the pityriasis lichenoides chronica (PLC) and the pityriasis lichenoides et varioliformis acuta (PLEVA) groups. Read More

Dermatol Ther 2020 Mar 11:e13303. Epub 2020 Mar 11.

Department of Dermatology, Hospital San Juan de Dios, La Plata, Argentina.

An Bras Dermatol 2020 Mar - Apr;95(2):259-260. Epub 2020 Feb 19.

Department of Dermatology and Radiotherapy, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Botucatu, SP, Brazil. Electronic address:

Front Immunol 2020 21;11:280. Epub 2020 Feb 21.

Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Br J Dermatol 2020 Feb 28. Epub 2020 Feb 28.

Division of Dermatology, Department of Medicine, University of Toronto School of Medicine, Toronto, ON, Canada.

Background: Pityriasis lichenoides (PL) is a papulosquamous dermatosis affecting both children and adults, for which no standard treatment currently exists.

Objectives: To characterize different treatment options and develop an evidence-based treatment algorithm for PL.

Methods: A systematic search of published literature on PL treatments was performed on 23 December 2017 via the MEDLINE, Embase, CINAHL, CENTRAL, ClinicalTrials. Read More

Am J Dermatopathol 2020 Jan;42(1):1-10

Department of Dermatology, Hôpital Necker-Enfants Malades, Paris, France.

Introduction: Pityriasis lichenoides (PL) is an infrequent skin disorder. The clinical manifestations are usually specific enough for a reliable diagnosis, although the histopathological assessment of a biopsy is sometimes needed to differentiate between PL and a range of other diseases. The objectives of this study were to review cases of PL managed in our hospital, confirm the classical histopathological features of PL, and identify signs that may be of value in the diagnosis of PL. Read More

Dermatology 2020 24;236(2):117-122. Epub 2019 Sep 24.

Department of Dermatology, School of Medicine, Hospital das Clínicas, Universidade de São Paulo, São Paulo, Brazil.

Background: Poikilodermatous mycosis fungoides (pMF) is characterized by poikiloderma areas, typically involving the major flexural areas and trunk. Its presentation can be generalized or admixed with other forms of MF. Previous studies fail to correlate the clinical presentation with prognosis and laboratory findings. Read More

Dermatol Clin 2019 Oct 6;37(4):471-482. Epub 2019 Aug 6.

Department of Dermatology and Cutaneous Surgery, University of South Florida Morsani College of Medicine, 12901 Bruce B. Downs Boulevard, Tampa, FL 33612, USA. Electronic address:

Pityriasis lichenoides et varioliformis acuta and pityriasis lichenoides chronica are the 2 main subtypes of pityriasis lichenoides. They represent the acute and chronic forms of the disease; both may have clonal T cells. Several treatment modalities are used, but it has been difficult to determine efficacy because of the possibility of spontaneous remission. Read More

BMJ Case Rep 2019 Aug 26;12(8). Epub 2019 Aug 26.

Department of Dermatology, Hospitals of Coimbra University, Coimbra, Portugal.

J Drugs Dermatol 2019 Jul;18(7):690-691

Pityriasis lichenoides et varioliformis acuta (PLEVA) is a rare, self-limited, cutaneous disorder of unknown etiology. Clinically, PLEVA is characterized by the sudden onset of scaly, erythematous macules and papules localized to the trunk and proximal extremities. We report the case of a patient who presented with multiple erythematous papules and plaques on the palms, forearms, and dorsal feet. Read More

J Eur Acad Dermatol Venereol 2019 Nov 8;33(11):2039-2049. Epub 2019 Aug 8.

Section of Dermatology and Venereology, Department of Medicine, University of Verona, Verona, Italy.

Pityriasis lichenoides (PL) represents a spectrum of inflammatory skin diseases comprising pityriasis lichenoides et varioliformis acuta (PLEVA) and pityriasis lichenoides chronica (PLC). This study aimed to provide a summary of effective treatments for PL. A systematic review was performed according to PRISMA guidelines for studies investigating PL treatment including ≥3 subjects and published in English between 1 January 1970 and 15 April 2019. Read More

J Am Acad Dermatol 2020 Jan 12;82(1):156-160. Epub 2019 Jul 12.

Department of Dermatology, University of South Carolina, Charleston, South Carolina.

Background: Syphilis is often misdiagnosed clinically, and biopsies might be required.

Objective: To determine histopathologic features that distinguish secondary syphilis from pityriasis lichenoides (PL), pityriasis rosea (PR), and early mycosis fungoides (MF).

Methods: Histopathologic features of 100 cases of syphilis, 110 cases of PL, 72 cases of PR, and 101 cases of MF were compared. Read More

Arch Dermatol Res 2019 Nov 12;311(9):673-678. Epub 2019 Jul 12.

Department of Dermatology, Damietta General Hospital, Damietta, Egypt.

Mycosis fungoides (MF) is the most common form of cutaneous T cell lymphoma (CTCL) with many clinical variants including papular and pityriasis lichenoides chronica (PLC)-like variants. During psoralen and ultraviolet A (PUVA) treatment of MF, PLC-like papular lesions were observed to appear. The exact nature of these lesions is not fully understood. Read More

Acta Dermatovenerol Croat 2019 Mar;27(1):37-39

Chao-Kuei Juan, MD, Department of Dermatology, Taichung Veterans General Hospital, Taichung , Taiwan, No. 1650, Section 4, Taiwan Boulevard Taichung 40705 , Taiwan;

Dear Editors, Pityriasis lichenoides (PL)-like mycosis fungoides (MF) is a rare variant of MF, presenting clinical findings of PL but histological features of MF. It was first reported by Ko et al. (1) and only a few cases have been reported since (2-5). Read More

Am J Surg Pathol 2019 08;43(8):1129-1134

Department of Dermatology, Research Unit Dermatopathology, Medical University of Graz, Graz, Austria.

Papular mycosis fungoides (PMF) is a rare variant of mycosis fungoides (MF). The exact nosology and prognosis of PMF are still unclear. We retrospectively identified cases of PMF from the files of the Department of Dermatology of the Medical University of Graz, Austria, and checked the follow-up data. Read More

JAAD Case Rep 2019 Mar 1;5(3):264-266. Epub 2019 Mar 1.

Department of Pathology, University of Michigan, Ann Arbor, Michigan.

Indian J Dermatol Venereol Leprol 2019 Nov-Dec;85(6):660-663

Department of Dermatology, K. E. M. Hospital, Pune, Maharashtra, India.

Febrile ulceronecrotic Mucha-Habermann disease is a very rare and severe variant of pityriasis lichenoides et varioliformis acuta. Adult cases are difficult to diagnose as in the early course they can mimic erythema multiforme or lymphomatoid papulosis. We report a case of a 38-year-old woman who presented with 90% body surface area involvement, fever, diarrhea, malaise and associated comorbidities. Read More

Asia Pac J Clin Oncol 2019 Aug 27;15(4):262-265. Epub 2019 Feb 27.

Department of Medical Oncology, The Canberra Hospital, Garran, Australian Capital Territory, Australia.

Checkpoint inhibition is the mainstay of treatment in metastatic melanoma. More recently combined cytotoxic T-lymphocyte antigen-4 and programmed-death-1 blockade has resulted in improved response rates and overall survival in treatment naïve patients compared to monotherapy albeit with increased rates of adverse events. Dermatologic toxicities are an emerging consequence of the use of checkpoint inhibitors and have reportedly been more prevalent with the use of combined therapy. Read More

Open Access Maced J Med Sci 2019 Jan 25;7(2):221-223. Epub 2019 Jan 25.

University of Rome G. Marconi, Rome, Italy.

Aim: This prospective clinical study presents the experiences with NB-UVB monotherapy in the treatment of PLC on Vietnamese patients.

Methods: We enrolled at National Hospital of Dermatology and Venereology (NHDV), Vietnam, 29 PLC patients with generalised disease involving at least 60% of the total body surface (based on Nine's Rule) and/or failed to respond to other modalities of treatment. Patients were treated with NB-UVB followed the guideline of the psoriatic treatment of AAD-2010, three times weekly. Read More

Open Access Maced J Med Sci 2019 Jan 23;7(2):198-199. Epub 2019 Jan 23.

University of Rome G. Marconi, Rome, Italy.

Background: Pityriasis lichenoides et varioliformis acuta (PLEVA) is an uncommon condition which presents acutely with papulo-vesicles that may develop necrotic, ulcerative, or hemorrhagic changes.

Aim: We studied clinical, and treatment characteristics of PLEVA hospitalised patients at our hospital from September 2009 to December 2014.

Methods: The records of 15 PLEVA patients were retrospectively reviewed. Read More

Dermatol Ther 2019 07 7;32(4):e12833. Epub 2019 Feb 7.

Department of Dermatology, Beijing Children's Hospital, Capital Medical University, Beijing, China.

Pityriasis lichenoides et varioliformis acuta (PLEVA) pemphigoides is an uncommon skin disease, which is characterized by the appearance of blistering skin lesions in patients with PLEVA. We present a 3-year-old boy, who was diagnosed with PLEVA pemphigoides. Combined treatment of oral methotrexate and corticosteroids was more effective than corticosteroids alone on this patient. Read More

Gac Med Mex 2018;154(Supp 2):S41-S49

Unidad de Fototerapia. Hospital General Dr. Manuel Gea González, Ciudad de México, México.

Introduction: T-cell lymphoid dyscrasia is a group of different, infrequent, epitheliotropic inflammatory dermatosis that precede cutaneous T-cell lymphomas. Treatment with ultraviolet radiation is safe and efficacious.

Objective: To describe responses to treatment, secondary effects and complications. Read More

Pediatr Rev 2018 Nov;39(11):e54-e56

Division of Dermatology, Department of Pediatrics, Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, OH.

Eur J Dermatol 2018 Dec;28(6):834-835

Department of Dermatology, AP-HP, Henri Mondor Hospital, Créteil, France, EA 7379 EpiDermE (Epidémiologie en Dermatologie et Evaluation des Thérapeutiques), Université Paris-Est Créteil Val de Marne (UPEC), Créteil, France.

Dermatol Ther 2018 11 3;31(6):e12734. Epub 2018 Oct 3.

Department of Dermatology, Universidad Autónoma de Nuevo León, Hospital Universitario "Dr. José Eleuterio González" y Facultad de Medicina, Monterrey, Nuevo León, Mexico.

Photodermatol Photoimmunol Photomed 2019 Mar 13;35(2):100-105. Epub 2018 Nov 13.

Research Unit for Photodermatology, Department of Dermatology, Medical University of Graz, Graz, Austria.

Background: Medical phototherapy can lead to the manifestation of polymorphic light eruption (PLE), though little is known about the frequency of such events.

Aims: The aim of this Austrian single center study was to retrospectively investigate over a 4-year time period the frequency of PLE in patients prone to the condition and patients with other diseases under phototherapy (mainly narrow-band and broad-band UVB).

Materials And Methods: The data for analysis were obtained from the electronic health and patient record database and patient files of the Photodermatology Unit, Department of Dermatology, Medical University of Graz, Austria. Read More

Hautarzt 2018 Oct;69(Suppl 1):22-24

Klinik und Poliklinik für Dermatologie und Allergologie, Ludwig-Maximilians-Universität München, Frauenlobstr. 9-11, 80337, München, Deutschland.

Australas J Dermatol 2019 May 9;60(2):e154-e156. Epub 2018 Sep 9.

Department of Dermatology, Cutaneous Lymphoma Clinic, "Andreas Sygros" Hospital, University of Athens Medical School, Athens, Greece.

Dermatol Ther 2018 09 22;31(5):e12681. Epub 2018 Aug 22.

Department of Pathology, School of Medicine, Gaziosmanpasa University, Tokat, Turkey.

Pityriasis lichenoides (PL) is a spectrum of inflammatory skin diseases which include PL et varioliformis acuta (PLEVA) and PL chronica (PLC) as two ends of the disease and rarely both entities can coexist on the same patient. Treatment options are based on case series-reports, and anecdotes, and include topical corticosteroids, topical immunomodulators, systemic antibiotics (tetracycline, erythromycin), and phototherapy. Herein, we report a 13-year-old boy, exhibiting mixed manifestations of PLEVA and PLC lesions concurrently, with a rapid and dramatic response to azithromycin monotherapy. Read More

Trop Doct 2018 Oct 12;48(4):348-349. Epub 2018 Aug 12.

4 Professor, Department of Pediatrics, Lady Hardinge Medical College and associated Kalawati Saran Children Hospital, New Delhi, India.

A seven-year-old boy with nephrotic syndrome presented with a frequent rash along with relapse of nephrotic syndrome. Clinical and histological features were suggestive of pityriasis lichenoides et varioliformis acuta (PLEVA). Treatment of the condition with doxycycline led to the cure of the lesions as well as the relapses. Read More

Med J Malaysia 2018 06;73(3):125-130

Hospital Kuala Lumpur, Department of Dermatology, Kuala Lumpur, Malaysia.

Introduction: Ultraviolet phototherapies are important treatment modalities for a wide range of dermatological conditions. We aim to describe the utilization of phototherapy in the Department of Dermatology Hospital Kuala Lumpur.

Methods: This is a 5-year retrospective audit on patients who underwent phototherapy between 2011 and 2015. Read More

Clin Exp Dermatol 2019 01 26;44(1):102-105. Epub 2018 Jun 26.

Division of Dermatology, Department of Medicine, Phramongkutklao Hospital, Bangkok, Thailand.

Clin Exp Dermatol 2019 Jan 20;44(1):64. Epub 2018 Jun 20.

Mansoura Dermatology, Venerology and Leprology Hospital, 5 Amien Alsamanoudy Street, from AbdelsalamAaref Street, Mansoura, Egypt.

Pan Afr Med J 2018 12;29:25. Epub 2018 Jan 12.

Centre d'Anatomopathologie Hassane, Rabat, Maroc.

Pityriasis lichenoides is a rare inflammatory dermatosis occurring in young subjects. It evolves into rashes on the trunk and the limbs which regress spontaneously. We here report a particular case of pityriasis lichenoides whose diagnosis was adjusted due to the scar appearance of the lesions. Read More

Am J Surg Pathol 2018 08;42(8):1101-1112

Research Unit Dermatopathology, Department of Dermatology, Medical University of Graz, Graz, Austria.

Pityriasis lichenoides (PLs) is an uncommon skin disease of unknown etiology. In recent years, an atypical form of PL has been described, showing overlapping features with mycosis fungoides (MF) and lymphomatoid papulosis. We studied 66 patients with an initial histopathologic diagnosis of PL (M:F=34:32; median age, 25 y; range, 7 to 85 y). Read More

Clin Exp Dermatol 2018 Oct 30;43(7):846-848. Epub 2018 May 30.

Dermatology Service, Hôpital Nord, Assistance Publique Hôpitaux de Marseille, Aix Marseille Université, Marseille, France.

Clin Exp Dermatol 2018 Aug 23;43(6):703-707. Epub 2018 May 23.

Department of Dermatology, Kyorin University School of Medicine, Tokyo, Japan.

Although numerous infective agents, including varicella zoster virus (VZV), have been described in association with pityriasis lichenoides et varioliformis acuta (PLEVA) and pityriasis lichenoides chronica (PLC), none has been identified consistently in these lesions. We sought to immunohistochemically identify VZV glycoprotein (g)E antigens in the vascular endothelium in PLEVA and PLC lesions, based on our previous observation that gE was detected in the vascular endothelium and eccrine unit up until 2 months and 2.5, respectively, years after herpes zoster (HZ) infection. Read More

Dermatol Online J 2017 Nov 15;23(11). Epub 2017 Nov 15.

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York.

Background: Lymphomatoid drug reactions can mimic endogenous T and B cell lymphoproliferative diseases.

Objectives: We present a novel form of cutaneous drug reaction with features of pityriasis lichenoides (PL), a recognized form of T cell dyscrasia.

Methods: Ten cases were studied where a cutaneous eruption exhibiting semblance to PL within a few weeks to months after starting a particular drug. Read More

J Dermatol Sci 2018 May 1;90(2):105-111. Epub 2018 Feb 1.

Department of Dermatology, Fujita Health University School of Medicine, Toyoake, Japan.

Classifying inflammatory skin diseases is challenging, especially for the expanding group of disorders triggered by genetic factors resulting in hyperactivated innate immunity that result in overlapping patterns of dermal and epidermal inflammation with hyperkeratosis. For such conditions, the umbrella term "autoinflammatory keratinization diseases" (AIKD) has been proposed. AIKD encompasses diseases with mixed pathomechanisms of autoinflammation and autoimmunity, and includes IL-36 receptor antagonist (IL-36Ra)-related pustulosis, CARD14-mediated pustular psoriasis, pityriasis rubra pilaris (PRP) type V, and familial keratosis lichenoides chronica (KLC). Read More

Am Fam Physician 2018 Jan;97(1):38-44

Emory University School of Medicine, Atlanta, GA, USA.

Pityriasis rosea is a common self-limiting rash that usually starts with a herald patch on the trunk and progresses along the Langer lines to a generalized rash over the trunk and limbs. The diagnosis is based on clinical and physical examination findings. The herald patch is an erythematous lesion with an elevated border and depressed center. Read More

Clin Exp Dermatol 2018 Jun 19;43(4):404-409. Epub 2018 Jan 19.

Department of Dermatology, American University of Beirut Medical Center, Beirut, Lebanon.

Background: Plasmacytoid dendritic cells (pDCs) and their product, type I interferons (IFNs), have been implicated in the pathogenesis of several skin disorders characterized by an interface dermatitis (ID) pattern, such as lichen planus (LP). A type I IFN signature has previously been documented in pityriasis lichenoides (PL). Although pDCs are known to be the main source and most potent producers of local type I IFNs, their role in PL has not been investigated. Read More

Pediatr Dermatol 2018 Mar 9;35(2):213-219. Epub 2018 Jan 9.

Department of Dermatology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.

Background/objectives: Pityriasis lichenoides is an uncommon papulosquamous disorder of unknown etiology. The objective of this study was to review the clinical features and treatment responses of individuals with pityriasis lichenoides seen at a tertiary referral center.

Methods: Seventy-five patients diagnosed with pityriasis lichenoides between 1997 and 2013 were reviewed, and 46 had long-term follow-up via telephone interviews. Read More