521 results match your criteria Pityriasis Lichenoides


Aciclovir for treatment of pityriasis lichenoides?

Authors:
A Abdelmaksoud

Clin Exp Dermatol 2018 Jun 20. Epub 2018 Jun 20.

Mansoura Dermatology, Venerology and Leprology Hospital, 5 Amien Alsamanoudy Street, from AbdelsalamAaref Street, Mansoura, Egypt.

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[Pityriasis lichenoides: not always a clear-cut diagnosis!]

Pan Afr Med J 2018 12;29:25. Epub 2018 Jan 12.

Centre d'Anatomopathologie Hassane, Rabat, Maroc.

Pityriasis lichenoides is a rare inflammatory dermatosis occurring in young subjects. It evolves into rashes on the trunk and the limbs which regress spontaneously. We here report a particular case of pityriasis lichenoides whose diagnosis was adjusted due to the scar appearance of the lesions. Read More

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Pityriasis Lichenoides, Atypical Pityriasis Lichenoides, and Related Conditions: A Study of 66 Cases.

Am J Surg Pathol 2018 May 30. Epub 2018 May 30.

Research Unit Dermatopathology, Department of Dermatology, Medical University of Graz, Graz, Austria.

Pityriasis lichenoides (PLs) is an uncommon skin disease of unknown etiology. In recent years, an atypical form of PL has been described, showing overlapping features with mycosis fungoides (MF) and lymphomatoid papulosis. We studied 66 patients with an initial histopathologic diagnosis of PL (M:F=34:32; median age, 25 y; range, 7 to 85 y). Read More

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Varicella zoster virus as a possible trigger for the development of pityriasis lichenoides et varioliformis acuta: retrospective analysis of our institutional cases.

Clin Exp Dermatol 2018 May 23. Epub 2018 May 23.

Department of Dermatology, Kyorin University School of Medicine, Tokyo, Japan.

Although numerous infective agents, including varicella zoster virus (VZV), have been described in association with pityriasis lichenoides et varioliformis acuta (PLEVA) and pityriasis lichenoides chronica (PLC), none has been identified consistently in these lesions. We sought to immunohistochemically identify VZV glycoprotein (g)E antigens in the vascular endothelium in PLEVA and PLC lesions, based on our previous observation that gE was detected in the vascular endothelium and eccrine unit up until 2 months and 2.5, respectively, years after herpes zoster (HZ) infection. Read More

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Pityriasis lichenoides-like drug reaction: A clinical histopathologic study of 10 cases.

Dermatol Online J 2017 Nov 15;23(11). Epub 2017 Nov 15.

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York.

Background: Lymphomatoid drug reactions can mimic endogenous T and B cell lymphoproliferative diseases.

Objectives: We present a novel form of cutaneous drug reaction with features of pityriasis lichenoides (PL), a recognized form of T cell dyscrasia.

Methods: Ten cases were studied where a cutaneous eruption exhibiting semblance to PL within a few weeks to months after starting a particular drug. Read More

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November 2017

Autoinflammatory keratinization diseases: An emerging concept encompassing various inflammatory keratinization disorders of the skin.

J Dermatol Sci 2018 May 1;90(2):105-111. Epub 2018 Feb 1.

Department of Dermatology, Fujita Health University School of Medicine, Toyoake, Japan.

Classifying inflammatory skin diseases is challenging, especially for the expanding group of disorders triggered by genetic factors resulting in hyperactivated innate immunity that result in overlapping patterns of dermal and epidermal inflammation with hyperkeratosis. For such conditions, the umbrella term "autoinflammatory keratinization diseases" (AIKD) has been proposed. AIKD encompasses diseases with mixed pathomechanisms of autoinflammation and autoimmunity, and includes IL-36 receptor antagonist (IL-36Ra)-related pustulosis, CARD14-mediated pustular psoriasis, pityriasis rubra pilaris (PRP) type V, and familial keratosis lichenoides chronica (KLC). Read More

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May 2018
5 Reads

Pityriasis Rosea: Diagnosis and Treatment.

Am Fam Physician 2018 Jan;97(1):38-44

Emory University School of Medicine, Atlanta, GA, USA.

Pityriasis rosea is a common self-limiting rash that usually starts with a herald patch on the trunk and progresses along the Langer lines to a generalized rash over the trunk and limbs. The diagnosis is based on clinical and physical examination findings. The herald patch is an erythematous lesion with an elevated border and depressed center. Read More

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January 2018
2 Reads

Possible role of plasmacytoid dendritic cells in pityriasis lichenoides.

Clin Exp Dermatol 2018 Jun 19;43(4):404-409. Epub 2018 Jan 19.

Department of Dermatology, American University of Beirut Medical Center, Beirut, Lebanon.

Background: Plasmacytoid dendritic cells (pDCs) and their product, type I interferons (IFNs), have been implicated in the pathogenesis of several skin disorders characterized by an interface dermatitis (ID) pattern, such as lichen planus (LP). A type I IFN signature has previously been documented in pityriasis lichenoides (PL). Although pDCs are known to be the main source and most potent producers of local type I IFNs, their role in PL has not been investigated. Read More

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June 2018
2 Reads

Pityriasis lichenoides: Long-term follow-up study.

Pediatr Dermatol 2018 Mar 9;35(2):213-219. Epub 2018 Jan 9.

Department of Dermatology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.

Background/objectives: Pityriasis lichenoides is an uncommon papulosquamous disorder of unknown etiology. The objective of this study was to review the clinical features and treatment responses of individuals with pityriasis lichenoides seen at a tertiary referral center.

Methods: Seventy-five patients diagnosed with pityriasis lichenoides between 1997 and 2013 were reviewed, and 46 had long-term follow-up via telephone interviews. Read More

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March 2018
4 Reads

Skin and coeliac disease, a lot to think about: a case series.

BMJ Case Rep 2018 Jan 4;2018. Epub 2018 Jan 4.

Pediatric Department, Hospital of Divino Espírito Santo of Ponta Delgada, Ponta Delgada - São Miguel, Azores, Portugal.

Coeliac disease (CD) is an autoimmune disease, characterised by a permanent sensitivity to gluten. It is being progressively recognised as a multisystemic disease, with multiple extraintestinal manifestations. Skin conditions (eg, dermatitis herpetiformis) are an example of its manifestations; however, its underlying mechanisms are still not well understood. Read More

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January 2018
2 Reads

A Fatal Case of Febrile Ulceronecrotic Mucha-Habermann Disease which Presenting as Toxic Epidermal Necrolysis.

Indian J Dermatol 2017 Nov-Dec;62(6):675

Department of Dermatology, Hangzhou Institute of Dermatology and Venereology, The Third People's Hospital of Hangzhou, Hangzhou, China.

Febrile ulceronecrotic Mucha-Habermann disease (FUMHD), a severe form of pityriasis lichenoides et varioliformis acuta, is an inflammatory dermatosis of unknown etiology manifested by ulcerative and necrotic lesions accompanied by systemic manifestations. The mortality rate of FUMHD is about 15%. It is reported here a case of FUMHD presenting as toxic epidermal necrolysis that resulted in multiple organ failure and death. Read More

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December 2017
4 Reads

Pitiryasis Lichenoides et Varioliformis Aacuta Associated With Human Herpesvirus 7.

Actas Dermosifiliogr 2017 Dec 5. Epub 2017 Dec 5.

Unidad de Dermatología y Venereología, Centro Hospitalario São João, EPE, Oporto, Portugal.

Pityriasis lichenoides et varioliformis acuta and pityriasis lichenoides chronica represent 2 ends of a disease spectrum of unknown etiology. Herein we describe 2 cases of pityriasis lichenoides et varioliformis acuta, in which human herpesvirus 7 DNA was detected in skin samples by polymerase chain reaction methodology, an association not previously described. This report may support the involvement of viral infection in the etiopathogeny of this disease. Read More

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December 2017
5 Reads

Relationship Between Pityriasis Lichenoides and Mycosis Fungoides: A Clinicopathological, Immunohistochemical, and Molecular Study.

Am J Dermatopathol 2018 Jun;40(6):409-415

Departments of Dermatology.

Background: Several cases of pityriasis lichenoides (PL) have been reported to evolve into mycosis fungoides (MF).

Objective: To elucidate clues to this progression.

Methods: Fifty-eight patients with PL between 2000 and 2013 (follow-up: 3-16 years, average: 8. Read More

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June 2018
3 Reads

[Polymorphic and itchy rash in a 21-year-old woman].

Internist (Berl) 2018 06;59(6):615-617

Klinik für Hautkrankheiten, Universitätsklinikum Jena, Erfurter Str. 35, 07743, Jena, Deutschland.

Pityriasis lichenoides et varioliformis acuta (PLEVA) is a common inflammatory disease which usually occurs in children and young adults. Characteristic is a polymorph clinical picture with papules, erosions, ulcers and haemorrhagic crusts compatible with many differential diagnoses. We report about a patient with PLEVA and describe possible differential diagnoses. Read More

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June 2018
2 Reads

Severe Mucha-Habermann-Like Ulceronecrotic Skin Disease in T-Cell Acute Lymphoblastic Leukemia Responsive to Basiliximab and Stem Cell Transplant.

Pediatr Dermatol 2017 Sep;34(5):e265-e270

Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

A 5-year-old girl with T-cell acute lymphoblastic leukemia (T-ALL) developed a progressive eruption of crusted papules and ulcerative plaques involving 80% of her body surface area with histopathology consistent with febrile ulceronecrotic Mucha-Habermann disease (FUMHD), although multiple specimens also contained clonal leukemic cells. Her skin disease was refractory to many classic treatments for FUMHD, including methotrexate, and became so severe that concern about superinfection prevented intensification of chemotherapy for her malignancy. The addition of basiliximab promoted gradual improvement of the skin, allowing for chemotherapy intensification and subsequent bone marrow transplantation, after which the eruption resolved completely. Read More

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September 2017
10 Reads

Autoinflammatory keratinization diseases.

J Allergy Clin Immunol 2017 Dec 28;140(6):1545-1547. Epub 2017 Jun 28.

Department of Dermatology, Fujita Health University School of Medicine, Toyoake, Japan.

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December 2017
4 Reads

Pityriasis lichenoides et varioliformis acuta in skin of color: new observations by dermoscopy.

Dermatol Pract Concept 2017 Jan 31;7(1):27-34. Epub 2017 Jan 31.

Department of Dermatology, S. Nijalingappa Medical College, Bagalkot, Karnataka, India.

Background: Pityriasis lichenoides is an uncommon skin disease that presents in three different forms: pityriasis lichenoides et varioliformis acuta (PLEVA), pityriasis lichenoides chronica (PLC) and febrile ulceronecrotic-Mucha-Habermann disease. These represent a spectrum of a disease. PLEVA presents as skin eruption of multiple, small, red papules that develop into polymorphic lesions with periods of varying remissions, as well as possible sequels of hyper/hypopigmentation and varicella-like scars. Read More

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January 2017
5 Reads

Pityriasis Lichenoides et Varioliformis Acuta and Psoriasis Vulgaris: Mere Coincidence or a Rare Association?

Chin Med J (Engl) 2017 02;130(4):501-502

Department of Dermatology, Peking Union Medical College Hospital, Beijing 100730, China.

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February 2017
9 Reads

[Paraviral exanthems].

Hautarzt 2017 Mar;68(3):211-216

Department of Dermatology, Godavari Foundation Medical College and Research Center, DUPMCJ, Nashik, Indien.

Paraviral exanthems are distinct skin diseases due to infections with different viruses. Although no virus has been identified so far in some exanthems, the main age of manifestation, the clinical course of the exanthem, and the extracutaneous symptoms are suggestive for a viral genesis. While many viral infections are a direct result of the infection, paraviral exanthems reflect the response of the immune system to the infectious pathogens. Read More

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March 2017
5 Reads

Use of Phototherapy in Children.

Pediatr Dermatol 2017 Mar 30;34(2):150-155. Epub 2017 Jan 30.

Department of Dermatology, Alder Hey Children's Hospital, Liverpool, UK.

Background: Phototherapy is a well-recognized treatment in adults and children. Previous articles have reported success in treating recalcitrant skin disorders such as atopic dermatitis (AD), psoriasis, pityriasis lichenoides chronica, and vitiligo in children.

Methods: This was a retrospective review over an 18-month period from June 2012 to December 2013 of all children receiving phototherapy in a tertiary pediatric dermatology center. Read More

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March 2017
4 Reads

Treatment of adult diffuse pityriasis lichenoides chronica with narrowband ultraviolet B: experience and literature review.

Clin Exp Dermatol 2017 Apr 23;42(3):303-305. Epub 2017 Jan 23.

Dermatology Department, Hospital Universitario Sanitas La Zarzuela, Universidad Francisco de Vitoria, Madrid, Spain.

Pityriasis lichenoides chronica (PLC) is an infrequent dermatosis of unknown aetiology, wholse evolution and response to treatment differs between children and adults. When PLC is recalcitrant or unresponsive to topical treatment, phototherapy is one of the main treatments used. We carried out a prospective study of adult diffuse PLC treated with narrowband ultraviolet B (NB-UVB). Read More

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April 2017
3 Reads

[Febrile ulceronecrotic Mucha-Habermann disease].

Rev Med Chil 2016 Sep;144(9):1214-1217

Anatomía Patológica, Hospital Clínico San Borja Arriarán, Universidad de Chile, Santiago, Chile.

Pityriasis lichenoides et varioliformis acuta (PLEVA), pityriasis lichenoides chronica (PLC) and febrile ulceronecrotic Mucha-Habermann disease (FUMHD) are considered different manifestations of the same disease. Febrile ulceronecrotic Mucha-Habermann disease is a rare, and potentially lethal illness which is characterized by fast progression of numerous papules that converge, ulcerate and form a plaque with a necrotic center, together with hemorrhagic vesicles and pustules that are associated with high fever and variable systemic symptoms. We report a 16 years old male presenting with erythematous papules with crusts and fever. Read More

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September 2016
8 Reads

Past, present and future of cutaneous lymphomas.

Authors:
Lorenzo Cerroni

Semin Diagn Pathol 2017 Jan 28;34(1):3-14. Epub 2016 Nov 28.

Research Unit Dermatopathology, Department of Dermatology, Medical University of Graz, Auenbruggerplatz 8, 8036 Graz, Austria. Electronic address:

Primary cutaneous lymphomas represent a broad group of diseases with different clinical, histopathological, phenotypic, molecular, and prognostic features. All cutaneous lymphomas share the same tropism of neoplastic lymphocytes for the skin, but precise classification is paramount for proper management of the patients. Primary cutaneous lymphomas are classified according to the schemes proposed by the European Organization for Research and Treatment of Cancer (EORTC)-Cutaneous Lymphomas Task Force together with the World Health Organization (WHO) in 2005, and the WHO classification of 2008 with the 2016 update. Read More

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January 2017
12 Reads

Pityriasis Lichenoides-like Mycosis Fungoides: Clinical and Histologic Features and Response to Phototherapy.

Ann Dermatol 2016 Oct 30;28(5):540-547. Epub 2016 Sep 30.

Department of Dermatology, Kosin University College of Medicine, Busan, Korea.

Background: Pityriasis lichenoides (PL)-like skin lesions rarely appear as a specific manifestation of mycosis fungoides (MF).

Objective: We investigated the clinicopathological features, immunophenotypes, and treatments of PL-like MF.

Methods: This study included 15 patients with PL-like lesions selected from a population of 316 patients diagnosed with MF at one institution. Read More

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October 2016
17 Reads

Phototherapy in children: Considerations and indications.

Clin Dermatol 2016 Sep-Oct;34(5):633-9. Epub 2016 May 24.

Harvard Medical School, Dermatology Program, Division of Allergy and Immunology, Department of Medicine, Boston Children's Hospital, Boston, MA. Electronic address:

Phototherapy can be a safe and effective treatment for various skin diseases in children. Special considerations governing the use of this treatment modality in pediatric populations include patient, family, and facility-based factors that are oriented around heightened concerns with regard to safety and tolerability of treatment. Although phototherapy has been found to be effective in a wide range of dermatologic conditions affecting pediatric populations, including psoriasis, atopic dermatitis, pityriasis lichenoides, cutaneous T-cell lymphoma, and vitiligo, there is need for additional research on other conditions in which phototherapy has shown promise. Read More

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May 2017
7 Reads

Successful treatment of pityriasis lichenoides chronica with narrow-band ultraviolet B therapy in a patient with Keratitis-Ichthyosis-Deafness syndrome: a case report.

Dermatol Online J 2016 May 15;22(5). Epub 2016 May 15.

Marmara University, School of Medicine, Department of Dermatology, Istanbul.

Keratitis-ichthyosis-deafness (KID) syndrome is a rare genodermatosis causing ichthyosis-like skin lesions, keratitis, and deafness. Herein, we report a patient with this rare syndrome in association with pityriasis lichenoides chronica, which was succesfully treated with narrow-band ultraviolet B phototherapy despite our concerns regarding the increased risk of squamous cell carcinoma, hyperpyrexia, and keratitis. Read More

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May 2016
9 Reads

Dermoscopy in General Dermatology: A Practical Overview.

Dermatol Ther (Heidelb) 2016 Dec 9;6(4):471-507. Epub 2016 Sep 9.

Department of Experimental and Clinical Medicine, Institute of Dermatology, University of Udine, Udine, Italy.

Over the last few years, dermoscopy has been shown to be a useful tool in assisting the noninvasive diagnosis of various general dermatological disorders. In this article, we sought to provide an up-to-date practical overview on the use of dermoscopy in general dermatology by analysing the dermoscopic differential diagnosis of relatively common dermatological disorders grouped according to their clinical presentation, i.e. Read More

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December 2016
24 Reads

Pityriasis lichenoides chronica-like drug eruption developing during pembrolizumab treatment for metastatic melanoma.

JAAD Case Rep 2016 Jul 17;2(4):343-5. Epub 2016 Aug 17.

Department of Dermatology, University of Iowa Hospitals and Clinics, Iowa City, Iowa; Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, Iowa.

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July 2016
7 Reads

Young Male With Painful Skin Necrosis.

Authors:
Ze-Hu Liu Hong Shen

Ann Emerg Med 2016 Sep;68(3):276-311

Department of Dermatology, Affiliated Third Hospital of Hangzhou, Anhui Medical University, Hangzhou, China.

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September 2016
2 Reads

Phototherapy for Pityriasis Lichenoides in the Pediatric Population: A Review of the Published Literature.

Am J Clin Dermatol 2016 Dec;17(6):583-591

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, 1475 NW 12th Ave., Miami, FL, 33136, USA.

Background: Pityriasis lichenoides (PL) is a dermatologic disorder that manifests in either the acute (pityriasis lichenoides et varioliformis acuta) or the chronic form (pityriasis lichenoides chronica, also known as parapsoriasis chronica). Traditional first-line therapy consists of corticosteroids or antibiotics; however, these treatments are often accompanied with multiple side effects and may be ineffective.

Objective: The goal of this study was to review the use of phototherapy for treating PL in the pediatric population. Read More

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December 2016
6 Reads

Febrile ulceronecrotic Mucha-Habermann disease in an 8-year-old boy responding to methotrexate.

Int J Dermatol 2016 Nov;55(11):1205-1209

ExpressMed Laboratories, Kingdom of Bahrain.

Background: Febrile ulceronecrotic Mucha-Habermann disease (FUMHD) is a rare fulminant variant of pityriasis lichenoides et varioliformis acuta (PLEVA) characterized by a rapidly progressive course with predominant ulceronecrotic lesions associated with fever and systemic manifestations. First described by Degos in 1966, it carries a high morbidity and is potentially fatal. The exact pathogenesis is not clear, but it is proposed to be the result of hypersensitivity reaction to an infection. Read More

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November 2016
6 Reads

Seronegative arthritis secondary to Mucha-Habermann disease.

Med Clin (Barc) 2016 Dec 24;147(12):564. Epub 2016 Jun 24.

Servicio de Reumatología, Hospital Universitario San Cecilio, Granada, España.

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December 2016
3 Reads

Pityriasis Lichenoides et Varioliformis Acuta: Remission with Hypopigmentation.

J Pediatr 2016 Sep 11;176:211-211.e1. Epub 2016 Jun 11.

Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany.

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September 2016
5 Reads

Pityriasis lichenoides chronica presenting with bilateral palmoplantar involvement.

Cutis 2016 May;97(5):345;347;358

Bay Dermatology/Largo Medical Center, Florida, USA.

Pityriasis lichenoides is an uncommon, acquired, idiopathic, self-limiting skin disease that poses a challenge to patients and clinicians to diagnose and treat. Several variants exist including pityriasis lichenoides et varioliformis acuta (PLEVA), pityriasis lichenoides chronica (PLC), and febrile ulcer-onecrotic Mucha-Habermann disease. Precise classification can be difficult due to an overlap of clinical and histologic features. Read More

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May 2016
4 Reads

Pityriasis lichenoides chronica responds to minocycline in three patients.

Int J Dermatol 2016 Sep 3;55(9):1027-9. Epub 2016 Jun 3.

Department of Dermatology, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia.

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September 2016
4 Reads

A fatal case of febrile ulceronecrotic Mucha-Habermann disease in a child.

JAAD Case Rep 2016 Mar 22;2(2):181-5. Epub 2016 Apr 22.

Department of Dermatology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

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March 2016
5 Reads

Paraviral exanthems.

Expert Rev Anti Infect Ther 2016 06;14(6):601-11

c School of Public Health and Primary Care , The Chinese University of Hong Kong and Prince of Wales Hospital , Shatin , Hong Kong.

Introduction: Paraviral exanthems are skin diseases suspected to be caused by viruses, with a single virus-exanthem relationship not universally accepted. Although most paraviral exanthems are self-remitting, accurate diagnoses are important as some patients might develop complications. Some of the differential diagnoses might cause serious complications, and some paraviral exanthems might lead to complications for at-risk groups such as pregnant women. Read More

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June 2016
4 Reads

Lymphomatoid Papulosis in Children and Adolescents: A Systematic Review.

Am J Clin Dermatol 2016 Aug;17(4):319-27

Department of Dermatology, The University of Texas, MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030-4095, USA.

Background: Lymphomatoid papulosis (LyP) is a lymphoproliferative disorder that is rare among adults and even rarer among children. In adults, LyP is associated with an increased risk of secondary lymphomas.

Objective: The aim of this systematic review was to describe the clinical and histopathological features of LyP in children, to assess the risk of associated lymphomas, and to compare the disease to the adult form. Read More

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August 2016
3 Reads

Seasonal variations in dermatologic and dermatopathologic diagnoses: a retrospective 15-year analysis of dermatopathologic data.

Int J Dermatol 2016 Oct 7;55(10):1115-8. Epub 2016 Apr 7.

Temple University School of Medicine, Philadelphia, PA, USA.

Background: Certain dermatologic conditions are known to show seasonal variations in frequency, the reasons for which are unclear but in some cases may be attributable to changes in ambient weather conditions.

Objectives: The current study was conducted to determine whether seasonal trends might exist for dermatologic conditions including erythema multiforme, guttate psoriasis, erythema dyschromicum perstans (ashy dermatosis), pityriasis lichenoides, and pityriasis rosea.

Methods: Data were derived from a 15-year retrospective review of electronic records from a large dermatopathology laboratory located in the mid-Atlantic region of the USA. Read More

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October 2016
7 Reads

Systematic review of cases of cutaneous T-cell lymphoma transformation in pityriasis lichenoides and small plaque parapsoriasis.

Authors:
C Sibbald E Pope

Br J Dermatol 2016 Oct 20;175(4):807-9. Epub 2016 Jun 20.

Department of Dermatology, University of Toronto, Toronto, ON, Canada.

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October 2016
1 Read

[Surface membrane markers (clusters of differentiation) used in dermatopathology (2): Inflammatory infiltrates].

Ann Dermatol Venereol 2016 Apr 14;143(4):311-7. Epub 2016 Mar 14.

Département de pathologie, hôpital Henri-Mondor, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil, France.

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April 2016
4 Reads

[Erythematosquamous dermatoses in adolescence].

Hautarzt 2016 Apr;67(4):293-7

Klinik für Dermatologie, Venerologie und Allergologie, Kinderdermatologische Ambulanz, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Deutschland.

Erythematosquamous dermatoses in adolescents comprise a wide range of differential diagnoses. Age-typical variations of the clinical manifestation, the need to differentiate common conditions from rare diseases as well as the tremendous psychosocial impact which the patients perceive especially in this vulnerable period of life can become major challenges for pediatric dermatologists. This article summarizes key features of common erythematosquamous dermatoses and less frequent skin diseases occurring during adolescence. Read More

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April 2016
6 Reads

Complete resolution of febrile ulceronecrotic Mucha-Habermann disease following infliximab therapy.

J Dtsch Dermatol Ges 2016 Feb 20;14(2):184-6. Epub 2016 Jan 20.

Department of Dermatology, Venereology, and Allergology, HELIOS St. Elisabeth Hospital, Oberhausen. Germany.

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February 2016
4 Reads

Febrile ulceronecrotic Mucha-Habermann disease: proposed diagnostic criteria and therapeutic evaluation.

Int J Dermatol 2016 Jul 23;55(7):729-38. Epub 2015 Dec 23.

Department of Dermatology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Febrile ulceronecrotic Mucha-Habermann disease (FUMHD) is a rare severe variant of pityriasis lichenoides et varioliformis acuta characterized clinically by aggressive ulceronecrotic skin lesions associated with high fever and histologically by features typical of pityriasis lichenoides et varioliformis acuta. Despite the continuous addition of new case reports, no definite diagnostic criteria have been established, and an optimum treatment is still waiting. Herein, we review the different aspects of this rare entity, including pathogenesis, clinical and histopathological features, differential diagnosis, course, prognosis, and outcome. Read More

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July 2016
6 Reads

Successful therapy of cyclosporin A in pityriasis lichenoides et varioliformis acuta preceded by hand, foot and mouth disease.

Antivir Ther 2016 15;21(3):273-5. Epub 2015 Dec 15.

Department of Dermatology, School of Medicine, Medical University of Silesia, Katowice, Poland.

To our knowledge, there are no previously published cases of enteroviral infection complicated by pityriasis lichenoides et varioliformis acuta (PLEVA). A 30-year-old woman is reported with a severe form of PLEVA, preceded by hand, foot and mouth disease. Immunosuppressive treatment with cyclosporin A resulted in rapid clinical improvement. Read More

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January 2018
7 Reads

Febrile Ulceronecrotic Mucha-Habermann Disease: Two Cases with Excellent Response to Methotrexate.

Pediatr Dermatol 2015 Nov-Dec;32(6):e307-8. Epub 2015 Oct 8.

Department of Dermatology, Center for Health and Healing, Oregon Health and Science University, Portland, Oregon.

Febrile ulceronecrotic Mucha-Habermann disease (FUMHD), a severe form of pityriasis lichenoides et varioliformis acuta (PLEVA), featuring large, ulcerative, necrotic skin plaques, high fever, and other systemic symptoms, is a rare disorder of unknown etiology. No randomized controlled trials have established treatment guidelines and multiple modalities are often employed, making it difficult to assess the efficacy of any single agent. We report two cases of this condition in which treatment with methotrexate plus antibiotic treatment for superinfection led to rapid improvement. Read More

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September 2016
5 Reads

Commentary about papular mycosis fungoides, lymphomatoid papulosis and lymphomatoid pityriasis lichenoides: more similarities than differences.

J Cutan Pathol 2016 Apr 22;43(4):303-12. Epub 2015 Dec 22.

Department of Dermatology, The Warren Alpert Medical School of Brown University, Providence, RI, USA.

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April 2016
5 Reads

[Febrile ulceronecrotic Mucha-Habermann disease].

Arch Pediatr 2016 Jan 6;23(1):82-5. Epub 2015 Nov 6.

Service de pédiatrie générale, CHU Ambroise-Paré, AP-HP, 9, avenue Charles-de-Gaulle, 92100 Boulogne-Billancourt, France. Electronic address:

Pityriasis lichenoides et varioliformis acuta (PLEVA) is an inflammatory skin disease that is unknown to pediatricians. The ulceronecrotic febrile form is a rare and potentially lethal variant. We report the case of a 7-year-old boy with a papulovesicular eruption lasting for 4 weeks, secondarily associated with ulcers and necrotic crusts, fever, and systemic signs. Read More

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January 2016
3 Reads

Adalimumab-Induced Pityriasis Lichenoides Chronica That Responded Well to Methotrexate in a Patient With Psoriasis.

Actas Dermosifiliogr 2016 Mar 29;107(2):167-9. Epub 2015 Oct 29.

Servicio de Anatomía Patológica, Complejo Hospitalario de Jaén, Jaén, España.

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March 2016
3 Reads

Methotrexate Treatment in Children with Febrile Ulceronecrotic Mucha-Habermann Disease: Case Report and Literature Review.

Case Rep Dermatol Med 2015 27;2015:357973. Epub 2015 Aug 27.

Department of Pathology, Faculty of Medicine, Osmangazi University, Eskişehir, Turkey.

Febrile Ulceronecrotic Mucha-Habermann disease is a rare and potentially fatal variant of pityriasis lichenoides et varioliformis acuta and is characterized by high fever, constitutional symptoms, and acute oncet of ulceronecrotic lesions. We present an 11-year-old male with Febrile Ulceronecrotic Mucha-Habermann disease who was cured with methotrexate and review the use of methotrexate for this disorder in the pediatric age group with the relevant literature. Read More

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September 2015
10 Reads