Case Rep Dermatol 2017 May-Aug;9(2):35-39. Epub 2017 Jun 8.

Department of Dermatology, CHU Sart Tilman, University of Liège, Liège, Belgium.

Eruptive seborrheic keratoses (ESK) are rare in dermatology. They are usually inflammatory in nature and may be encountered as Leser-Trélat sign. ESK may also be simultaneously observed with hepatic angiomas, chemotherapy, segmental neurofibromatosis, HIV or erythrodermic pityriasis rubra pilaris, psoriasis, and drug eruption. Read More

World J Clin Cases 2017 Jun;5(6):203-211

Francisco Urbina, Emilio Sudy, Dermatologists in Private Practice, Santiago de Chile 6760964, Chile.

Pityriasis rosea (PR) is a common erythemato-squamous dermatosis which almost always, is easily diagnosed. Mostly the disease presents in its classical form. However, clinical dermatology is all about variations and PR is not an exception. Read More

Postepy Dermatol Alergol 2017 Jun 29;34(3):276-278. Epub 2017 May 29.

Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland.

J Allergy Clin Immunol 2017 Jun 28. Epub 2017 Jun 28.

Department of Dermatology, Fujita Health University School of Medicine, Toyoake, Japan.

Indian Dermatol Online J 2017 May-Jun;8(3):217-218

Department of Pathology, Turgut Ozal University Faculty of Medicine, Ankara, Turkey.

Dermatol Clin 2017 Jul 4;35(3):351-363. Epub 2017 May 4.

Department of Pediatric Dermatology, National Institute of Pediatrics, Insurgentes Sur 3700-C, Insurgentes Cuicuilco, México City 04530, México.

Atopic dermatitis is the leading cause of pediatric dermatology visits in developed nations. Recurrent, itchy rashes in typical locations and a family/personal history of atopy helps to identify children with disease. Most cases (85%) are diagnosed by age 5 years. Read More

Int J Dermatol 2017 May 31. Epub 2017 May 31.

Barau Dikko Teaching Hospital, Kaduna, Nigeria.

Background: Although pityriasis versicolor (PV) is a common fungal infection of the skin affecting up to 50% of the population in the tropics, little is known about what patients know, believe, or feel about the condition.

Methods: In a cross-sectional questionnaire study of 608 consecutive patients attending the General Outpatient Department and Skin Clinic of a public hospital in Kaduna, Nigeria, self-report of PV, knowledge about its causes, treatments used by patients, and perception and feelings about the condition were assessed.

Results: Overall 608 patients were studied (239/594 [40. Read More

JAAD Case Rep 2017 May 16;3(3):243-245. Epub 2017 May 16.

Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

Pan Afr Med J 2017 23;26:31. Epub 2017 Jan 23.

UFR des Sciences de la Santé, Université de Thiès, Sénégal.

We report two cases of Pityriasis versicolor (PV) in infants aged 12 and 18 months. The latter were brought to medical attention because of hypochromic and achromic, round macules involving the limbs and the face. Physical examination of their mothers showed voluntary depigmentation for cosmetic purposes due to the use of corticosteroids and hydroquinone, on average, over a 5-year period. Read More

Curr Med Chem 2017 Apr 4. Epub 2017 Apr 4.

Neurofarba Dept., Section of Pharmaceutical and Nutriceutical Sciences, Università degli Studi di Firenze, Via U. Schiff 6, 50019 Sesto Fiorentino (Florence). Italy.

Malassezia spp. are lipophilic yeasts not only present in the normal skin microflora, but also responsible of skin-related diseases (pityriasis versicolor, seborrheic/atopic dermatitis and dandruff) as well as systemic fungal infections in humans and animals. Their treatment and eradication are mainly based on old azole drugs, which are characterized by poor compliance, unpredictable clinical efficacy, emerging resistance and several side effects. Read More

Ann Dermatol 2017 Apr 24;29(2):137-142. Epub 2017 Mar 24.

Department of Dermatology, Gachon University School of Medicine, Incheon, Korea.

Background: Demodicosis is a parasitic skin disease caused by Demodex mites, and the determination of mite density per square centimeter is important to diagnose demodicosis. Standardized skin surface biopsy (SSSB) and direct microscopic examination (DME) are commonly used to determine Demodex mites density (Dd). However, no study has previously compared these two methods with respect to clinical types and distribution patterns of demodicosis. Read More

J Clin Microbiol 2017 Jun 5;55(6):1883-1893. Epub 2017 Apr 5.

Department of Dermatology, University and University Hospital of Zurich, Zurich, Switzerland

Malassezia is a genus of lipid-dependent yeasts. It is associated with common skin diseases such as pityriasis versicolor and atopic dermatitis and can cause systemic infections in immunocompromised individuals. Owing to the slow growth and lipid requirements of these fastidious yeasts, convenient and reliable antifungal drug susceptibility testing assays for Malassezia spp. Read More

J Dermatol 2017 Mar 29. Epub 2017 Mar 29.

Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan.

Am J Dermatopathol 2017 Mar 24. Epub 2017 Mar 24.

*Department of Pathology, University of South Dakota-Sanford School of Medicine, Sioux Falls, SD; and †Departments of Pathology and Dermatology, Cleveland Clinic Foundation, Cleveland, OH.

Background: Direct immunofluorescence (DIF) is considered pivotal in diagnosing autoimmune blistering diseases. Our goal was to examine the necessity of DIF in intraepidermal bullous cases, of which pemphigus vulgaris (PV) is the prototype.

Methods: Sixty-six cases from 2010 to 2014 submitted for DIF with an intraepidermal blistering disease listed in the differential diagnosis were reviewed by 2 board-certified dermatopathologists to see if they would order DIF based on routine histologic findings. Read More

Med Mal Infect 2017 Jun 31;47(4):301-302. Epub 2017 Mar 31.

DISSAL Department of Dermatology, IRCCS AOU, San Martino-IST, Largo Rosanna Benzi, 10, 16132 Genoa, Italy. Electronic address:

Cutan Ocul Toxicol 2017 Apr 19:1-3. Epub 2017 Apr 19.

a Department of Dermatology , Bozok University School of Medicine , Yozgat , Turkey and.

Pityriasis rosea is a common, self-limited and inflammatory skin disease. The etiology is not clearly known. Viral agents, autoimmunity, psychogenic factors and drugs have all been suggested as risk factors. Read More

Biomed Pharmacother 2017 May 22;89:1422-1430. Epub 2017 Mar 22.

Department of Microbiology, Medicinal Plants Research Center of Barij, Kashan, Iran. Electronic address:

A. sieberi essential oil has been used for treatment of hardly curable infectious ulcers in Middle East Medicine and has been famous due to its wormicide effects. In this review, we evaluated the potency of A. Read More

Int J STD AIDS 2017 Jan 1:956462417702312. Epub 2017 Jan 1.

Department of Dermatology, Weill Cornell Medical College, New York, NY 10021, USA.

Pityriasis rosea (PR) is an acute self-limited exanthem characterized by oval erythematous patches with scale and may be difficult to differentiate from secondary syphilis. A rapid plasma reagin (RPR) test can be used to rule in secondary syphilis with high sensitivity and specificity. A retrospective study was performed on patients at Weill Cornell Medicine, who were diagnosed with PR from 2000 to 2016 and also received RPR testing at the time of diagnosis. Read More

Curr Microbiol 2017 Jun 22;74(6):671-677. Epub 2017 Mar 22.

Fungal and Parasitic Molecular Biology Laboratory, Faculty of Medicine, University of Sfax, Rue Magida Boulila, Sfax, 3029, Tunisia.

Lipophilic yeast Malassezia species is widely found on the skin surface of humans and other animals. This fungus can cause pityriasis versicolor, Malassezia folliculitis, and seborrheic dermatitis. Still now, there is a problem with species identification of Malassezia with conventional methods. Read More

Dermatol Online J 2017 Feb 15;23(2). Epub 2017 Feb 15.

2Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York.

Pityriasis Rosea (PR) is a common skin disorderencountered in daily practice. Although its etiologyhas not been established, there has been widespreadresearch into possibilities. The lack of its characteristicmanifestations, specifically the herald patch andtruncal involvement, can lead to pitfalls in diagnosis. Read More

Br J Dermatol 2017 Mar 16. Epub 2017 Mar 16.

St John's Institute of Dermatology, King's College London (Guy's Campus), London, UK.

Pityriasis rubra pilaris (PRP) represents a group of rare chronic inflammatory skin disorders in which ~1 in 20 affected individuals show autosomal dominant inheritance. In such cases, there may be gain-of-function mutations in CARD14, encoding caspase recruitment domain-containing protein 14 (CARD14) that activates the non-canonical nuclear factor-kappa B (NF-κB) pathway, thereby promoting cutaneous inflammation. Here, we report a mother and son with PRP due to a new missense mutation in CARD14 and describe the beneficial clinical effects of ustekinumab, a monoclonal antibody against interleukins-12 and -23, in both subjects. Read More

Br J Dermatol 2017 Mar 10. Epub 2017 Mar 10.

Department of Dermatology, Shinshu University, Graduate School of Medicine, Matsumoto, Japan.

In 2012, gain-of-function mutations in CARD14, which encodes caspase recruitment domain family member 14, were identified as the cause of familial psoriasis vulgaris (PV) and familial pityriasis rubra pilaris (PRP).(1,2) We and another group reported that CARD14 variants are associated with generalized pustular psoriasis (GPP) and palmoplantar pustular psoriasis (PPP).(3-5) The other reports mentioned that CARD14 mutations in individuals with GPP and erythrodermic PRP. Read More

Arch Dermatol Res 2017 May 9;309(4):311-314. Epub 2017 Mar 9.

Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Assiut University, Assiut, Egypt.

Pityriasis rubra pilaris (PRP) and plaque psoriasis (PP) are two distinctive erythemato-squamous skin diseases that often have to be differentiated from each other and from other similar dermatoses. Dermoscopy has been proven to aid the clinical diagnosis of several inflammatory disorders, minimizing the need for skin biopsy. Our aim was to determine the dermoscopic patterns of PRP compared to PP and to assess the significance of certain dermoscopic criteria in the diagnosis of PRP. Read More

J Dermatolog Treat 2017 Jun 9:1-2. Epub 2017 Jun 9.

a The Charles Centre, Department of Dermatology , St. Vincent's University Hospital , Dublin , Ireland.

J Fam Pract 2017 Mar;66(3):181-183

Department of Dermatology, College of Medicine, Mayo Clinic, Rochester, MN, USA.

The patient presented with a salmon-colored rash from head to toe. The distinctive clinical presentation and a biopsy pointed to an uncommon diagnosis. Read More

Dermatol Pract Concept 2017 Jan 31;7(1):27-34. Epub 2017 Jan 31.

Department of Dermatology, S. Nijalingappa Medical College, Bagalkot, Karnataka, India.

Background: Pityriasis lichenoides is an uncommon skin disease that presents in three different forms: pityriasis lichenoides et varioliformis acuta (PLEVA), pityriasis lichenoides chronica (PLC) and febrile ulceronecrotic-Mucha-Habermann disease. These represent a spectrum of a disease. PLEVA presents as skin eruption of multiple, small, red papules that develop into polymorphic lesions with periods of varying remissions, as well as possible sequels of hyper/hypopigmentation and varicella-like scars. Read More

Semin Diagn Pathol 2017 May 10;34(3):226-236. Epub 2017 Feb 10.

Department of Radiation Oncology, The Ohio State University, Columbus, OH, USA.

This review article focuses on the spongiotic tissue reaction pattern and some of the common entities that practicing pathologists can frequently encounter in their practice. The spongiotic tissue reaction pattern is the single most common one encountered in the routine analysis of inflammatory dermatoses, and the most non-specific one as well. Spongiotic dermatoses include a very large list of disorders which are best grouped under neutrophilic, eosinophilic, miliarial, follicular and pityriasiform forms of spogiosis. Read More

Medicine (Baltimore) 2017 Feb;96(8):e6184

Department of Hematology, The First Affiliated Hospital of Chongqing University of Medical Sciences, Chongqing, China.

Rationale: Paraneoplastic pemphigus (PNP) is an autoimmune syndrome associated with neoplasms. The treatment approach principally includes suppressing the immunity, but its therapeutic effect is not satisfying.

Patient Concerns: We report a case of paraneoplastic pemphigus linked to chronic lymphocytic leukemia in a 63-year-old man. Read More

Chin Med J (Engl) 2017 02;130(4):501-502

Department of Dermatology, Peking Union Medical College Hospital, Beijing 100730, China.

Indian J Dermatol 2017 Jan-Feb;62(1):95

DISSAL Department of Dermatology, IRCCS AOU San Martino-IST, 16132 Genoa, Italy. E-mail:

J Clin Diagn Res 2016 Dec 1;10(12):WD01-WD02. Epub 2016 Dec 1.

Student, Department of Nursing, Student Research Committee, School of Nursing and Midwifery, Iran University of Medical Science , Tehran, Iran .

Pityriasis Rosea (PR) is a common skin disease and characterized by generalized scaly eruptions typically on the trunk and proximal extremities. Atypical presentations of PR are common and can be a diagnostic challenge for clinicians. Here we present a case of a 26-year-old female who presented with a sudden onset of several asymptomatic, erythematous and scaly plaques on her trunk. Read More

JAAD Case Rep 2017 Jan 4;3(1):78-81. Epub 2017 Feb 4.

Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama.

J Am Acad Dermatol 2017 Jun 10;76(6):1161-1175. Epub 2017 Feb 10.

Department of Dermatology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. Electronic address:

Epidermodysplasia verruciformis (EV) is a rare genodermatosis characterized by abnormal susceptibility to cutaneous human beta-papillomavirus infections causing persistent flat warts or pityriasis versicolor-like lesions. This generalized verrucous skin disorder resembles generalized verrucosis, but these 2 conditions are distinguished by differences in clinical manifestation and the human papillomavirus types involved. A breakthrough in our understanding of EV was the discovery that homozygous inactivating mutations in TMC6 (EVER1) and TMC8 (EVER2) determine susceptibility to this disorder; however, they have not solved all EV cases fully. Read More

Hautarzt 2017 Mar;68(3):211-216

Department of Dermatology, Godavari Foundation Medical College and Research Center, DUPMCJ, Nashik, Indien.

Paraviral exanthems are distinct skin diseases due to infections with different viruses. Although no virus has been identified so far in some exanthems, the main age of manifestation, the clinical course of the exanthem, and the extracutaneous symptoms are suggestive for a viral genesis. While many viral infections are a direct result of the infection, paraviral exanthems reflect the response of the immune system to the infectious pathogens. Read More

J Pathol Transl Med 2017 Mar 13;51(2):148-151. Epub 2017 Feb 13.

Department of Molecular Genetics, National Research Center (NRC), Cairo University, Cairo, Egypt.

Background: Pityriasis rosea (PR) is a common papulosquamous skin disease in which an infective agent may be implicated. Toll-like receptors (TLRs) play an important role in immune responses and in the pathophysiology of inflammatory skin diseases. Our aim was to determine the possible roles of TLRs 3, 7, 8, and 9 in the pathogenesis of PR. Read More

Int J Dermatol 2017 Jul 10;56(7):e147-e148. Epub 2017 Feb 10.

Department of Dermatology, Seth Gordhandas Sunderdas Medical College and King Edward Memorial Hospital, Mumbai, India.

G Ital Dermatol Venereol 2017 Apr;152(2):190-191

Unit of Dermatology, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.

Pediatr Dermatol 2017 Mar 30;34(2):150-155. Epub 2017 Jan 30.

Department of Dermatology, Alder Hey Children's Hospital, Liverpool, UK.

Background: Phototherapy is a well-recognized treatment in adults and children. Previous articles have reported success in treating recalcitrant skin disorders such as atopic dermatitis (AD), psoriasis, pityriasis lichenoides chronica, and vitiligo in children.

Methods: This was a retrospective review over an 18-month period from June 2012 to December 2013 of all children receiving phototherapy in a tertiary pediatric dermatology center. Read More

Acta Dermatovenerol Croat 2016 Dec;24(4):312-313

Efstathia Pasmatzi, MD, Department of Dermatology, School of Medicine, University of Patras, 26504 Rio-Patras, Greece;

Dear Editor, Pityriasis rosea is a common, acute, and self-limiting dermatosis, which is associated with the endogenous systemic reactivation of human herpesvirus (HHV)-6 and/or HHV-7 (1). It predominantly affects individuals of both sexes in their second or third decade of life and is clinically characterized by the occurrence of an initial erythematosquamous plaque followed by the appearance of disseminated similar but smaller lesions one or two weeks later. Several patients develop systemic symptoms such as nausea, anorexia, malaise, headache, fever, arthralgia, and lymphadenopathy that may precede or accompany the eruption; the latter follows the cleavage lines of the trunk creating the configuration of a Christmas tree and spontaneously resolves within 4 to 8 weeks. Read More

Acta Dermatovenerol Croat 2016 Dec;24(4):282-287

Corresponding author: Rania Abdel Hay, MD, 13th Abrag Othman, Kournish el Maadi, Cairo 11431, Egypt;

Human herpesvirus (HHV) 6 and 7 are involved in the pathogenesis of pityriasis rosea (PR). Our aim was to evaluate the role of the innate immune response in PR through the detection of Toll-like receptors (TLR) 2, 3, 4, 7, 8, and 9 expression in the skin of affected patients and to detect the possibility of being induced by HHV-6 and/or HHV-7 viral coexistence in these patients. Twenty-four patients with PR and 24 healthy controls were included in this case-control study. Read More

Acta Dermatovenerol Croat 2016 Dec;24(4):274-281

Professor Asja Prohić, MD, PhD, Department of Dermatovenerology, University Clinical Center of Sarajevo, Bolnicka 25, 71000 Sarajevo, Bosnia and Herzegovina;

There are differences with respect to the commonly isolated Malassezia species, not only between healthy individuals and the patients with various skin diseases, but also between different countries. We investigated the species composition of Malassezia microflora on the skin of patients with Malassezia-associated diseases and of healthy subjects (HS). Two hundred and fifty skin scrapings from patients with pityriasis versicolor (PV), seborrheic dermatitis (SD), atopic dermatitis (AD), psoriasis (PS), and healthy subjects (HS), fifty each, were inoculated into Sabouraud dextrose agar and into modified Dixon agar and identified using conventional culture-based methods. Read More

JAMA Dermatol 2017 Apr;153(4):304-308

Department of Dermatology and Venereology, University Hospital of Lausanne, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.

Importance: Treatment of pityriasis rubra pilaris (PRP) is solely based on its resemblance to psoriasis rather than any knowledge of its pathomechanism. Insight into pathogenic mediators of inflammation is essential for targeted and valid treatment options that could replace previous serendipitous therapeutic approaches in refractory PRP.

Objective: To determine whether blockade of the interleukin 23-helper T cell 17 (IL-23-TH17) pathway with ustekinumab represents an efficacious and, based on its proinflammatory cytokine profile, targeted treatment option in PRP. Read More

Mycoses 2017 May 25;60(5):338-342. Epub 2017 Jan 25.

Department of Biostatistics, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Pityriasis versicolor (PV) is a common superficial fungal disease. Possibility of emergence of resistant strains to azoles, and difficulty in differentiation of hypopigmented PV and early vitiligo, encouraged us to evaluate the efficacy of topical tacrolimus (a calcineurin inhibitor agent with proven in vitro anti-Malassezia effect) for PV treatment generally and its effect on PV-induced hypopigmentation specifically.

Objectives: To evaluate the efficacy of topical tacrolimus on pityriasis versicolor. Read More

BMJ Case Rep 2017 Jan 23;2017. Epub 2017 Jan 23.

Department of Dermatology, Saint Louis University, Saint Louis, Missouri, USA.

Pityriasis rosea is a dermatological disease with a well-documented clinical appearance, but less is known about causes and treatment. Bell's palsy is a neurological condition leading to acute idiopathic hemifacial paralysis. Recent studies indicate that human herpesvirus (HHV) 6-7 reactivation may be a contributing factor to both conditions. Read More

Clin Exp Dermatol 2017 Apr 23;42(3):303-305. Epub 2017 Jan 23.

Dermatology Department, Hospital Universitario Sanitas La Zarzuela, Universidad Francisco de Vitoria, Madrid, Spain.

Pityriasis lichenoides chronica (PLC) is an infrequent dermatosis of unknown aetiology, wholse evolution and response to treatment differs between children and adults. When PLC is recalcitrant or unresponsive to topical treatment, phototherapy is one of the main treatments used. We carried out a prospective study of adult diffuse PLC treated with narrowband ultraviolet B (NB-UVB). Read More

BMJ Case Rep 2017 Jan 18;2017. Epub 2017 Jan 18.

Unit of Dermatology, University of Padua, Padua, Italy.

Pityriasis versicolor is one of the most frequent epidermal mycotic infections in the world, but its atrophic variant is rarely described. The aetiology of the atrophy is still unknown, and two main hypotheses have been formulated, one suggesting a correlation with long-term use of topical steroids and the other a delayed type hypersensitivity to epicutaneous antigens derived from components of the fungus. Atrophic pityriasis versicolor is a benign disease, but needs to be distinguished from other more severe skin diseases manifesting with cutaneous atrophy. Read More

Semin Diagn Pathol 2017 May 14;34(3):220-225. Epub 2016 Dec 14.

Division of Surgical Pathology & Cytopathology, University of Virginia Health System, Room 3020, University of Virginia Hospital, 1215 Lee Street, Charlottesville, VA 22908-0214, United States. Electronic address:

Psoriasis vulgaris (PV)-the prototypical "psoriasiform" dermatitis-may assume a spectrum of histologic appearances, depending on whether it has been treated or not. Because of that relative lack of morphological uniformity, other skin disorders that feature epidermal acanthosis, with or without associated inflammation, may be confused diagnostically with PV. This brief review considers the clinicopathologic attributes of PV and its imitators, including chronic spongiotic dermatitides, lichen simplex chronicus, prurigo nodularis, pityriasis rubra pilaris, psoriasiform secondary syphilis, and Reiter syndrome. Read More

BMJ 2017 Jan 12;356:i6534. Epub 2017 Jan 12.

Centre of Evidence Based Dermatology, University of Nottingham, Nottingham, UK.

Turk J Med Sci 2016 Dec 20;46(6):1740-1742. Epub 2016 Dec 20.

Department of Infectious Diseases and Clinical Microbiology, Bolu İzzet Baysal State Hospital, Bolu, Turkey.

Background/aim: This study aimed to evaluate the demographic, clinical, and epidemiological features of pityriasis rosea (PR) in a cohort of 46 children in Yozgat, a city in the Central Anatolia Region of Turkey.

Materials And Methods: Forty-six children with PR were monitored at regular intervals (1, 2, 4, and 12 weeks) for 3 months from the time of diagnosis. A complete evaluation of the patient was performed at each visit. Read More